NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|37731389|gb|AAN75260|]
View 

cytochrome oxidase subunit II, partial (mitochondrion) [Melanoplus spretus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
COX2 super family cl33359
cytochrome c oxidase subunit II; Provisional
 1-44 1.65e-25

cytochrome c oxidase subunit II; Provisional


The actual alignment was detected with superfamily member MTH00154:

Pssm-ID: 214438 [Multi-domain]  Cd Length: 227  Bit Score: 92.20  E-value: 1.65e-25
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 37731389    1 SYEYSDFENIEFDTYMTPENDLEINGFRLLDVDNRTILPMNTEV 44
Cdd:MTH00154 107 SYEYSDFKNIEFDSYMIPTNELENNGFRLLDVDNRLVLPMNTQI 150
 
Name Accession Description Interval E-value
COX2 MTH00154
cytochrome c oxidase subunit II; Provisional
 1-44 1.65e-25

cytochrome c oxidase subunit II; Provisional


Pssm-ID: 214438 [Multi-domain]  Cd Length: 227  Bit Score: 92.20  E-value: 1.65e-25
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 37731389    1 SYEYSDFENIEFDTYMTPENDLEINGFRLLDVDNRTILPMNTEV 44
Cdd:MTH00154 107 SYEYSDFKNIEFDSYMIPTNELENNGFRLLDVDNRLVLPMNTQI 150
CcO_II_C cd13912
C-terminal domain of Cytochrome c Oxidase subunit II; Cytochrome c Oxidase (CcO), the terminal ...
 1-44 9.64e-22

C-terminal domain of Cytochrome c Oxidase subunit II; Cytochrome c Oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of prokaryotes. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits varies from three to five in bacteria and up to 13 in mammalian mitochondria. Only subunits I and II are essential for function. Subunits I, II, and III of mammalian CcO are encoded within the mitochondrial genome and the remaining 10 subunits are encoded within the nuclear genome. Subunit II contains a copper-copper binuclear site called CuA, which is believed to be involved in electron transfer from cytochrome c to the binuclear center (active site) in subunit I.


Pssm-ID: 259979 [Multi-domain]  Cd Length: 130  Bit Score: 79.92  E-value: 9.64e-22
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 37731389   1 SYEYSDFENIEFDTYMTPENDLEINGFRLLDVDNRTILPMNTEV 44
Cdd:cd13912  15 SYEYSDFNDLEFDSYMIPEDDLEKGQLRLLEVDNRLVVPVNTHI 58
COX2 pfam00116
Cytochrome C oxidase subunit II, periplasmic domain;
1-44 4.22e-20

Cytochrome C oxidase subunit II, periplasmic domain;


Pssm-ID: 395066 [Multi-domain]  Cd Length: 120  Bit Score: 75.52  E-value: 4.22e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 37731389     1 SYEYSDFENIEFDTYMTPENDLEINGFRLLDVDNRTILPMNTEV 44
Cdd:pfam00116  13 SYEYTDFGDLEFDSYMIPTEDLEEGQLRLLEVDNRVVLPVETHI 56
 
Name Accession Description Interval E-value
COX2 MTH00154
cytochrome c oxidase subunit II; Provisional
 1-44 1.65e-25

cytochrome c oxidase subunit II; Provisional


Pssm-ID: 214438 [Multi-domain]  Cd Length: 227  Bit Score: 92.20  E-value: 1.65e-25
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 37731389    1 SYEYSDFENIEFDTYMTPENDLEINGFRLLDVDNRTILPMNTEV 44
Cdd:MTH00154 107 SYEYSDFKNIEFDSYMIPTNELENNGFRLLDVDNRLVLPMNTQI 150
CcO_II_C cd13912
C-terminal domain of Cytochrome c Oxidase subunit II; Cytochrome c Oxidase (CcO), the terminal ...
 1-44 9.64e-22

C-terminal domain of Cytochrome c Oxidase subunit II; Cytochrome c Oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of prokaryotes. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits varies from three to five in bacteria and up to 13 in mammalian mitochondria. Only subunits I and II are essential for function. Subunits I, II, and III of mammalian CcO are encoded within the mitochondrial genome and the remaining 10 subunits are encoded within the nuclear genome. Subunit II contains a copper-copper binuclear site called CuA, which is believed to be involved in electron transfer from cytochrome c to the binuclear center (active site) in subunit I.


Pssm-ID: 259979 [Multi-domain]  Cd Length: 130  Bit Score: 79.92  E-value: 9.64e-22
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 37731389   1 SYEYSDFENIEFDTYMTPENDLEINGFRLLDVDNRTILPMNTEV 44
Cdd:cd13912  15 SYEYSDFNDLEFDSYMIPEDDLEKGQLRLLEVDNRLVVPVNTHI 58
COX2 pfam00116
Cytochrome C oxidase subunit II, periplasmic domain;
1-44 4.22e-20

Cytochrome C oxidase subunit II, periplasmic domain;


Pssm-ID: 395066 [Multi-domain]  Cd Length: 120  Bit Score: 75.52  E-value: 4.22e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 37731389     1 SYEYSDFENIEFDTYMTPENDLEINGFRLLDVDNRTILPMNTEV 44
Cdd:pfam00116  13 SYEYTDFGDLEFDSYMIPTEDLEEGQLRLLEVDNRVVLPVETHI 56
COX2 MTH00140
cytochrome c oxidase subunit II; Provisional
 1-44 1.62e-19

cytochrome c oxidase subunit II; Provisional


Pssm-ID: 214430 [Multi-domain]  Cd Length: 228  Bit Score: 76.52  E-value: 1.62e-19
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 37731389    1 SYEYSDFENIEFDTYMTPENDLEINGFRLLDVDNRTILPMNTEV 44
Cdd:MTH00140 107 SYEYSDFSVIEFDSYMVPENELELGDFRLLEVDNRLVLPYSVDT 150
COX2 MTH00117
cytochrome c oxidase subunit II; Provisional
 1-42 5.98e-19

cytochrome c oxidase subunit II; Provisional


Pssm-ID: 177178 [Multi-domain]  Cd Length: 227  Bit Score: 74.95  E-value: 5.98e-19
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 37731389    1 SYEYSDFENIEFDTYMTPENDLEINGFRLLDVDNRTILPMNT 42
Cdd:MTH00117 107 SYEYTDYKDLSFDSYMIPTQDLPNGHFRLLEVDHRMVIPMES 148
COX2 MTH00139
cytochrome c oxidase subunit II; Provisional
 1-44 4.57e-18

cytochrome c oxidase subunit II; Provisional


Pssm-ID: 214429 [Multi-domain]  Cd Length: 226  Bit Score: 72.83  E-value: 4.57e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 37731389    1 SYEYSDFENIEFDTYMTPENDLEINGFRLLDVDNRTILPMNTEV 44
Cdd:MTH00139 107 SYEYSDFKNLSFDSYMIPTEDLSSGEFRLLEVDNRLVLPYKSNI 150
COX2 MTH00008
cytochrome c oxidase subunit II; Validated
 1-44 8.33e-18

cytochrome c oxidase subunit II; Validated


Pssm-ID: 164584 [Multi-domain]  Cd Length: 228  Bit Score: 72.20  E-value: 8.33e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 37731389    1 SYEYSDFENIEFDTYMTPENDLEINGFRLLDVDNRTILPMNTEV 44
Cdd:MTH00008 107 SYEYSDFSNLEFDSYMLPTSDLSPGQFRLLEVDNRAVLPMQTEI 150
COX2 MTH00168
cytochrome c oxidase subunit II; Provisional
 1-44 2.74e-17

cytochrome c oxidase subunit II; Provisional


Pssm-ID: 177223 [Multi-domain]  Cd Length: 225  Bit Score: 70.78  E-value: 2.74e-17
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 37731389    1 SYEYSDFENIEFDTYMTPENDLEINGFRLLDVDNRTILPMNTEV 44
Cdd:MTH00168 107 SYEYTDYNDLEFDSYMVPTQDLSPGQFRLLEVDNRLVLPMDSKI 150
COX2 MTH00185
cytochrome c oxidase subunit II; Provisional
 1-44 1.28e-15

cytochrome c oxidase subunit II; Provisional


Pssm-ID: 164736 [Multi-domain]  Cd Length: 230  Bit Score: 66.45  E-value: 1.28e-15
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 37731389    1 SYEYSDFENIEFDTYMTPENDLEINGFRLLDVDNRTILPMNTEV 44
Cdd:MTH00185 107 SYEYTDYEQLEFDSYMTPTQDLTPGQFRLLETDHRMVVPMESPI 150
COX2 MTH00098
cytochrome c oxidase subunit II; Validated
 1-44 2.13e-15

cytochrome c oxidase subunit II; Validated


Pssm-ID: 177160 [Multi-domain]  Cd Length: 227  Bit Score: 65.89  E-value: 2.13e-15
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 37731389    1 SYEYSDFENIEFDTYMTPENDLEINGFRLLDVDNRTILPMNTEV 44
Cdd:MTH00098 107 SYEYTDYEDLSFDSYMIPTSDLKPGELRLLEVDNRVVLPMEMPI 150
COX2 MTH00076
cytochrome c oxidase subunit II; Provisional
 1-42 2.20e-15

cytochrome c oxidase subunit II; Provisional


Pssm-ID: 164646 [Multi-domain]  Cd Length: 228  Bit Score: 65.57  E-value: 2.20e-15
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 37731389    1 SYEYSDFENIEFDTYMTPENDLEINGFRLLDVDNRTILPMNT 42
Cdd:MTH00076 107 SYEYTDYEDLSFDSYMIPTQDLTPGQFRLLEVDNRMVVPMES 148
COX2 MTH00051
cytochrome c oxidase subunit II; Provisional
 1-44 1.51e-14

cytochrome c oxidase subunit II; Provisional


Pssm-ID: 177126 [Multi-domain]  Cd Length: 234  Bit Score: 63.65  E-value: 1.51e-14
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 37731389    1 SYEYSDF--ENIEFDTYMTPENDLEINGFRLLDVDNRTILPMNTEV 44
Cdd:MTH00051 109 SYEYSDYgtDTIEFDSYMIPTSDLNSGDLRLLEVDNRLIVPIQTQV 154
COX2 MTH00023
cytochrome c oxidase subunit II; Validated
 1-44 1.52e-14

cytochrome c oxidase subunit II; Validated


Pssm-ID: 214402 [Multi-domain]  Cd Length: 240  Bit Score: 63.62  E-value: 1.52e-14
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 37731389    1 SYEYSDF--ENIEFDTYMTPENDLEINGFRLLDVDNRTILPMNTEV 44
Cdd:MTH00023 116 SYEYSDYegETLEFDSYMVPTSDLNSGDFRLLEVDNRLVVPINTHV 161
COX2 MTH00038
cytochrome c oxidase subunit II; Provisional
 1-44 3.41e-14

cytochrome c oxidase subunit II; Provisional


Pssm-ID: 177113 [Multi-domain]  Cd Length: 229  Bit Score: 62.41  E-value: 3.41e-14
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 37731389    1 SYEYSDFENIEFDTYMTPENDLEINGFRLLDVDNRTILPMNTEV 44
Cdd:MTH00038 107 SYEYTDYNDLEFDSYMVPTSDLSTGLPRLLEVDNRLVLPYQTPI 150
COX2 MTH00129
cytochrome c oxidase subunit II; Provisional
 1-44 6.65e-14

cytochrome c oxidase subunit II; Provisional


Pssm-ID: 177187 [Multi-domain]  Cd Length: 230  Bit Score: 61.65  E-value: 6.65e-14
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 37731389    1 SYEYSDFENIEFDTYMTPENDLEINGFRLLDVDNRTILPMNTEV 44
Cdd:MTH00129 107 SYEYTDYEDLGFDSYMIPTQDLTPGQFRLLEADHRMVVPVESPI 150
COX2 MTH00080
cytochrome c oxidase subunit II; Provisional
 1-44 7.47e-12

cytochrome c oxidase subunit II; Provisional


Pssm-ID: 177149 [Multi-domain]  Cd Length: 231  Bit Score: 56.17  E-value: 7.47e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 37731389    1 SYEYSDFENIEFDTYMTPENDLEINGFRLLDVDNRTILPMNTEV 44
Cdd:MTH00080 110 SYEFSDIPGLEFDSYMKSLDQLRLGEPRLLEVDNRCVLPCDTNI 153
COX2 MTH00027
cytochrome c oxidase subunit II; Provisional
 1-44 4.22e-11

cytochrome c oxidase subunit II; Provisional


Pssm-ID: 214405 [Multi-domain]  Cd Length: 262  Bit Score: 54.65  E-value: 4.22e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 37731389    1 SYEYSDF--ENIEFDTYMTPENDLEINGFRLLDVDNRTILPMNTEV 44
Cdd:MTH00027 139 SYSYEDYgeKNIEFDSYMIPTADLEFGDLRLLEVDNRLILPVDTNV 184
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH