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Conserved domains on  [gi|40737348|gb|AAR89103|]
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C4B1, partial [Homo sapiens]

Protein Classification

prenyltransferase/squalene oxidase repeat-containing protein( domain architecture ID 10030659)

prenyltransferase/squalene oxidase repeat-containing protein similar to Streptomyces anulatus copalyl diphosphate synthase and Aspergillus fumigatus squalene hopane cyclase afumA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ISOPREN_C2_like super family cl08267
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ...
 305-428 1.33e-66

This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.


The actual alignment was detected with superfamily member cd02896:

Pssm-ID: 415487 [Multi-domain]  Cd Length: 297  Bit Score: 214.45  E-value: 1.33e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40737348 305 SPGGVASLLRLPRGCGEQTMIYLAPTLAASRYLDKTEQWSTLPPETKDHAVDLIQKGYMRIQQFRKADGSYAAWLSRGSS 384
Cdd:cd02896   1 SPEGLEKLIRLPTGCGEQTMIKLAPTVYALRYLDTTNQWEKLGPERRDEALKYIRQGYQRQLSYRKPDGSYAAWKNRPSS 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 40737348 385 TWLTAFVLKVLSLAQEQVGGSPEKLQETSNWLLSQQQADGSFQD 428
Cdd:cd02896  81 TWLTAFVVKVFSLARKYIPVDQNVICGSVNWLISNQKPDGSFQE 124
A2M pfam00207
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ...
 90-178 2.41e-34

Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.


:

Pssm-ID: 459711 [Multi-domain]  Cd Length: 91  Bit Score: 123.08  E-value: 2.41e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40737348    90 NWLWRVETV--DRFQILTLWLPDSLTTWEIHGLSLSKTKGLCVATPVQLRVFREFHLHLRLPMSVRRFEQLELRPVLYNY 167
Cdd:pfam00207   1 TWLWDPVLVtdNGKASLSFTLPDSITTWRATAFALSPDTGLGVAEPPELVVFKPFFVDLNLPYSVRRGEQFELKATVFNY 80

                          90
                  ....*....|.
gi 40737348   168 LDKNLTVSVHV 178
Cdd:pfam00207  81 LDKCLKVRVRL 91
ANATO cd00017
Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments ...
 1-59 4.34e-21

Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to repeats in fibulins.


:

Pssm-ID: 237984  Cd Length: 70  Bit Score: 86.36  E-value: 4.34e-21
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 40737348   1 GQYASPTAKRCCQDGVTRLPMMRSCEQRAARV-QQPDCREPFLSCCQFAESLRKKSRDKG 59
Cdd:cd00017   7 AQYKDKELRKCCLDGMRENPMGQTCEERAAYItDGKECRKAFLECCVYAEELRDEEREDG 66
 
Name Accession Description Interval E-value
complement_C3_C4_C5 cd02896
Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, ...
 305-428 1.33e-66

Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.


Pssm-ID: 239226 [Multi-domain]  Cd Length: 297  Bit Score: 214.45  E-value: 1.33e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40737348 305 SPGGVASLLRLPRGCGEQTMIYLAPTLAASRYLDKTEQWSTLPPETKDHAVDLIQKGYMRIQQFRKADGSYAAWLSRGSS 384
Cdd:cd02896   1 SPEGLEKLIRLPTGCGEQTMIKLAPTVYALRYLDTTNQWEKLGPERRDEALKYIRQGYQRQLSYRKPDGSYAAWKNRPSS 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 40737348 385 TWLTAFVLKVLSLAQEQVGGSPEKLQETSNWLLSQQQADGSFQD 428
Cdd:cd02896  81 TWLTAFVVKVFSLARKYIPVDQNVICGSVNWLISNQKPDGSFQE 124
TED_complement pfam07678
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement ...
 291-428 7.15e-65

A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement components such as C3, C4 and C5. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved.


Pssm-ID: 462227 [Multi-domain]  Cd Length: 311  Bit Score: 210.23  E-value: 7.15e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40737348   291 ASDPLDTLGSEGALSPGGVASLLRLPRGCGEQTMIYLAPTLAASRYLDKTEQWStlpPETKDHAVDLIQKGYMRIQQFRK 370
Cdd:pfam07678   1 ISVVGDIMGPAIQVVPENLSSLLRLPYGCGEQNMVLFAPNVYVLRYLDKTNQLT---KLIKSKAIDYLEQGYQRQLSYKH 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 40737348   371 ADGSYAAWLSRGSSTWLTAFVLKVLSLAQEQVGGSPEKLQETSNWLLSQQQADGSFQD 428
Cdd:pfam07678  78 PDGSYSAFGHSPGSTWLTAFVLKVFAQARKFIFIDPEEICQSLRWLLSQQKPDGSFRE 135
A2M pfam00207
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ...
 90-178 2.41e-34

Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.


Pssm-ID: 459711 [Multi-domain]  Cd Length: 91  Bit Score: 123.08  E-value: 2.41e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40737348    90 NWLWRVETV--DRFQILTLWLPDSLTTWEIHGLSLSKTKGLCVATPVQLRVFREFHLHLRLPMSVRRFEQLELRPVLYNY 167
Cdd:pfam00207   1 TWLWDPVLVtdNGKASLSFTLPDSITTWRATAFALSPDTGLGVAEPPELVVFKPFFVDLNLPYSVRRGEQFELKATVFNY 80

                          90
                  ....*....|.
gi 40737348   168 LDKNLTVSVHV 178
Cdd:pfam00207  81 LDKCLKVRVRL 91
ANATO cd00017
Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments ...
 1-59 4.34e-21

Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to repeats in fibulins.


Pssm-ID: 237984  Cd Length: 70  Bit Score: 86.36  E-value: 4.34e-21
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 40737348   1 GQYASPTAKRCCQDGVTRLPMMRSCEQRAARV-QQPDCREPFLSCCQFAESLRKKSRDKG 59
Cdd:cd00017   7 AQYKDKELRKCCLDGMRENPMGQTCEERAAYItDGKECRKAFLECCVYAEELRDEEREDG 66
YfaS COG2373
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ...
 100-401 3.03e-15

Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];


Pssm-ID: 441940 [Multi-domain]  Cd Length: 1605  Bit Score: 78.20  E-value: 3.03e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40737348  100 RFQILTLW-----------------LPDSLTTWEIHGLSLSKT------KGLCVATPVQLRvfrefhlhLRLPmsvrRF- 155
Cdd:COG2373  929 RFKPVALFsgpvktdadgkatvsfdLPDFNGTLRVMAVAWSDDrfgsaeATVTVRKPLVVR--------PSLP----RFl 996

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40737348  156 ---EQLELRPVLYNYLDKNLTVSVHVS---PVEGLCLAGggglaQQVLVPAGSARPVAFSVVPTAAAAVSLKVVARGSFE 229
Cdd:COG2373  997 apgDRFELPVDVFNLTGKAGTVTVTLEasgGLTLEGEAT-----QTVTLAAGGRATVRFPLKAPDAGDAKVTVTATGGGE 1071

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40737348  230 fpvGDAVSKVLQIEKEGAIHREELVYELNPldhrGRTLEIPGNSDPNMIPDgdFNSY-VRVTASDPLDTlgsegalsPGG 308
Cdd:COG2373 1072 ---SDAREVELPVRPANPLVTRATSGVLAP----GESWTLPLDLPGGLRPG--TGSLtLSLSSSPPLDL--------AGL 1134

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40737348  309 VASLLRLPRGCGEQTMIYLAPTLaasrYLDKTEQWSTLPPETKDHAVDLIQKGYMRIQQFRKADGSYAAW-LSRGSSTWL 387
Cdd:COG2373 1135 LRYLLRYPYGCTEQTTSRALPLL----YLSDLAEALGLKGDKDAELRARIQAAIARLLSMQNSDGGFGLWpGGSESDPWL 1210

                        330
                 ....*....|....
gi 40737348  388 TAFVLKVLSLAQEQ 401
Cdd:COG2373 1211 TAYATDFLLEAREA 1224
ANATO smart00104
Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments ...
 11-45 2.21e-13

Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to a three-fold repeat in fibulins.


Pssm-ID: 197517  Cd Length: 35  Bit Score: 63.89  E-value: 2.21e-13
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 40737348     11 CCQDGVTRLPMMRSCEQRAARVQQPDCREPFLSCC 45
Cdd:smart00104   1 CCADGMRLAPMGETCEERAARINSGDCRKAFLQCC 35
ANATO pfam01821
Anaphylotoxin-like domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated ...
 11-45 4.21e-13

Anaphylotoxin-like domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to a three-fold repeat in fibulins.


Pssm-ID: 460347  Cd Length: 36  Bit Score: 63.06  E-value: 4.21e-13
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 40737348    11 CCQDGVTRLPMMRSCEQRAARVQQ-PDCREPFLSCC 45
Cdd:pfam01821   1 CCLDGMKRNPMGRSCEQRAARIKEgPRCRKAFLQCC 36
 
Name Accession Description Interval E-value
complement_C3_C4_C5 cd02896
Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, ...
 305-428 1.33e-66

Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.


Pssm-ID: 239226 [Multi-domain]  Cd Length: 297  Bit Score: 214.45  E-value: 1.33e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40737348 305 SPGGVASLLRLPRGCGEQTMIYLAPTLAASRYLDKTEQWSTLPPETKDHAVDLIQKGYMRIQQFRKADGSYAAWLSRGSS 384
Cdd:cd02896   1 SPEGLEKLIRLPTGCGEQTMIKLAPTVYALRYLDTTNQWEKLGPERRDEALKYIRQGYQRQLSYRKPDGSYAAWKNRPSS 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 40737348 385 TWLTAFVLKVLSLAQEQVGGSPEKLQETSNWLLSQQQADGSFQD 428
Cdd:cd02896  81 TWLTAFVVKVFSLARKYIPVDQNVICGSVNWLISNQKPDGSFQE 124
TED_complement pfam07678
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement ...
 291-428 7.15e-65

A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement components such as C3, C4 and C5. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved.


Pssm-ID: 462227 [Multi-domain]  Cd Length: 311  Bit Score: 210.23  E-value: 7.15e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40737348   291 ASDPLDTLGSEGALSPGGVASLLRLPRGCGEQTMIYLAPTLAASRYLDKTEQWStlpPETKDHAVDLIQKGYMRIQQFRK 370
Cdd:pfam07678   1 ISVVGDIMGPAIQVVPENLSSLLRLPYGCGEQNMVLFAPNVYVLRYLDKTNQLT---KLIKSKAIDYLEQGYQRQLSYKH 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 40737348   371 ADGSYAAWLSRGSSTWLTAFVLKVLSLAQEQVGGSPEKLQETSNWLLSQQQADGSFQD 428
Cdd:pfam07678  78 PDGSYSAFGHSPGSTWLTAFVLKVFAQARKFIFIDPEEICQSLRWLLSQQKPDGSFRE 135
A2M_like cd02891
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier ...
 305-428 6.01e-46

Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. This group contains another broadly specific proteinase inhibitor: pregnancy zone protein (PZP). PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system. This group also contains C3, C4 and C5 of vertebrate complement. The vertebrate complement is an effector of both the acquired and innate immune systems The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.


Pssm-ID: 239221 [Multi-domain]  Cd Length: 282  Bit Score: 160.25  E-value: 6.01e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40737348 305 SPGGVASLLRLPRGCGEQTMIYLAPTLAASRYLDKTEQWStlpPETKDHAVDLIQKGYMRIQQFRKADGSYAAWLSRG-S 383
Cdd:cd02891   1 SLGNLDYLLRYPYGCGEQTMSRAAPNLYVLKYLDATGQLT---PEIREKALEYIRKGYQRLLTYQRSDGSFSAWGNSDsG 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 40737348 384 STWLTAFVLKVLSLAQEQVGGSPEKLQETSNWLLSQQQADGSFQD 428
Cdd:cd02891  78 STWLTAYVVKFLSQARKYIDVDENVLARALGWLVPQQKEDGSFRE 122
A2M pfam00207
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ...
 90-178 2.41e-34

Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.


Pssm-ID: 459711 [Multi-domain]  Cd Length: 91  Bit Score: 123.08  E-value: 2.41e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40737348    90 NWLWRVETV--DRFQILTLWLPDSLTTWEIHGLSLSKTKGLCVATPVQLRVFREFHLHLRLPMSVRRFEQLELRPVLYNY 167
Cdd:pfam00207   1 TWLWDPVLVtdNGKASLSFTLPDSITTWRATAFALSPDTGLGVAEPPELVVFKPFFVDLNLPYSVRRGEQFELKATVFNY 80

                          90
                  ....*....|.
gi 40737348   168 LDKNLTVSVHV 178
Cdd:pfam00207  81 LDKCLKVRVRL 91
A2M_2 cd02897
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ...
 311-428 3.75e-32

Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.


Pssm-ID: 239227  Cd Length: 292  Bit Score: 123.46  E-value: 3.75e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40737348 311 SLLRLPRGCGEQTMIYLAPTLAASRYLDKTEQwstLPPETKDHAVDLIQKGYMRIQQFRKADGSYAAWLSR--GSSTWLT 388
Cdd:cd02897   7 NLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQ---LTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGESdkSGSTWLT 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 40737348 389 AFVLKVLSLAQEQVGGSPEKLQETSNWLLSQQQADGSFQD 428
Cdd:cd02897  84 AFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFRE 123
ISOPREN_C2_like cd00688
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ...
 305-427 7.70e-27

This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.


Pssm-ID: 238362 [Multi-domain]  Cd Length: 300  Bit Score: 109.18  E-value: 7.70e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40737348 305 SPGGVASLLRLPRG--------CGEQTMIYLAPTLAASRYLDKTEqwstlppeTKDHAVDLIQKGYMRIQQFRKADGSYA 376
Cdd:cd00688   1 IEKHLKYLLRYPYGdghwyqslCGEQTWSTAWPLLALLLLLAATG--------IRDKADENIEKGIQRLLSYQLSDGGFS 72

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 40737348 377 AWLSRG-SSTWLTAFVLKVLSLAQEQVGGSPEKLQETSNWLLSQQQADGSFQ 427
Cdd:cd00688  73 GWGGNDyPSLWLTAYALKALLLAGDYIAVDRIDLARALNWLLSLQNEDGGFR 124
ANATO cd00017
Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments ...
 1-59 4.34e-21

Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to repeats in fibulins.


Pssm-ID: 237984  Cd Length: 70  Bit Score: 86.36  E-value: 4.34e-21
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 40737348   1 GQYASPTAKRCCQDGVTRLPMMRSCEQRAARV-QQPDCREPFLSCCQFAESLRKKSRDKG 59
Cdd:cd00017   7 AQYKDKELRKCCLDGMRENPMGQTCEERAAYItDGKECRKAFLECCVYAEELRDEEREDG 66
YfaS COG2373
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ...
 100-401 3.03e-15

Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];


Pssm-ID: 441940 [Multi-domain]  Cd Length: 1605  Bit Score: 78.20  E-value: 3.03e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40737348  100 RFQILTLW-----------------LPDSLTTWEIHGLSLSKT------KGLCVATPVQLRvfrefhlhLRLPmsvrRF- 155
Cdd:COG2373  929 RFKPVALFsgpvktdadgkatvsfdLPDFNGTLRVMAVAWSDDrfgsaeATVTVRKPLVVR--------PSLP----RFl 996

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40737348  156 ---EQLELRPVLYNYLDKNLTVSVHVS---PVEGLCLAGggglaQQVLVPAGSARPVAFSVVPTAAAAVSLKVVARGSFE 229
Cdd:COG2373  997 apgDRFELPVDVFNLTGKAGTVTVTLEasgGLTLEGEAT-----QTVTLAAGGRATVRFPLKAPDAGDAKVTVTATGGGE 1071

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40737348  230 fpvGDAVSKVLQIEKEGAIHREELVYELNPldhrGRTLEIPGNSDPNMIPDgdFNSY-VRVTASDPLDTlgsegalsPGG 308
Cdd:COG2373 1072 ---SDAREVELPVRPANPLVTRATSGVLAP----GESWTLPLDLPGGLRPG--TGSLtLSLSSSPPLDL--------AGL 1134

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40737348  309 VASLLRLPRGCGEQTMIYLAPTLaasrYLDKTEQWSTLPPETKDHAVDLIQKGYMRIQQFRKADGSYAAW-LSRGSSTWL 387
Cdd:COG2373 1135 LRYLLRYPYGCTEQTTSRALPLL----YLSDLAEALGLKGDKDAELRARIQAAIARLLSMQNSDGGFGLWpGGSESDPWL 1210

                        330
                 ....*....|....
gi 40737348  388 TAFVLKVLSLAQEQ 401
Cdd:COG2373 1211 TAYATDFLLEAREA 1224
ANATO smart00104
Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments ...
 11-45 2.21e-13

Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to a three-fold repeat in fibulins.


Pssm-ID: 197517  Cd Length: 35  Bit Score: 63.89  E-value: 2.21e-13
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 40737348     11 CCQDGVTRLPMMRSCEQRAARVQQPDCREPFLSCC 45
Cdd:smart00104   1 CCADGMRLAPMGETCEERAARINSGDCRKAFLQCC 35
ANATO pfam01821
Anaphylotoxin-like domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated ...
 11-45 4.21e-13

Anaphylotoxin-like domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to a three-fold repeat in fibulins.


Pssm-ID: 460347  Cd Length: 36  Bit Score: 63.06  E-value: 4.21e-13
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 40737348    11 CCQDGVTRLPMMRSCEQRAARVQQ-PDCREPFLSCC 45
Cdd:pfam01821   1 CCLDGMKRNPMGRSCEQRAARIKEgPRCRKAFLQCC 36
AF1543 COG1689
Class II terpene cyclase family protein AF1543 [General function prediction only];
364-426 6.25e-03

Class II terpene cyclase family protein AF1543 [General function prediction only];


Pssm-ID: 441295 [Multi-domain]  Cd Length: 272  Bit Score: 38.17  E-value: 6.25e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 40737348 364 RIQQF----RKADGSYAAWLSRGSSTWLTAFVLKVLSLaqeqVGGSPEKLQETSNWLLSQQQADGSF 426
Cdd:COG1689  10 RTIEYvlkrQNEDGGFCAYPGLPSTLADTYYAVRILKL----LGEEVPNRDKTIEFLESCQDEEGGG 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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