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Conserved domains on  [gi|69219033|gb|AAZ04153|]
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NADH dehydrogenase subunit 2 (mitochondrion) [Choroedocus violaceipes]

Protein Classification

NADH dehydrogenase subunit 2( domain architecture ID 11475933)

NADH dehydrogenase subunit 2 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 1-340 1.43e-84

NADH dehydrogenase subunit 2; Provisional


:

Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 258.99  E-value: 1.43e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033    1 MANNSMKLLFLSSLVMGTILSISSNSWFGVWMGLEINLLSFIPMLTNNKNMMMNESPIKYFIVQAMASTMLLFSIILIQM 80
Cdd:MTH00160   1 MMMNSSKLLFLSTLIMGTLISISSNSWFGAWMGLEINLLSFIPLISNKKNLMSSESSLKYFLIQALASIILLFSIILNML 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033   81 KYTMgweMKIIPSMMISSSLLLKTGAAPFHFWFPEVMSASSWINCLTLMTWQKIAPMMVFSYCIQeTGFIFSITITSIII 160
Cdd:MTH00160  81 NLML---FNNISSMLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYLIN-NNFIIIIIILSAII 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033  161 GALGGLNQTSLRQILAYSSISHLGWMISSLIVSENAWELYFVTYSMLSLIMILLFKQMNLFSVIQIYSASNIKMEVKFMM 240
Cdd:MTH00160 157 GAIGGLNQTSLRKILAYSSINHLGWMLSSMMISENLWLIYFLIYSIISLSIILLFNKFNIFFLNQLFNSNNKSKKIKFLL 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033  241 FLSLLSLGGLPPFLGFLPKWIVMQYLVENNMTILLSIMVLFTTITLYYYMRISFSALIMTYTENSWSLSIKSNRESKSTL 320
Cdd:MTH00160 237 FLNLLSLGGLPPFLGFLPKWIIIQLLISNNMFFLLFILIMSSLITLYFYLRISYSSLMLNYNKNKWNLKKKKNKFSLILN 316

                        330       340
                 ....*....|....*....|
gi 69219033  321 SMaVMISTLGLIATPNLMFL 340
Cdd:MTH00160 317 FL-SFISLFGLILSSLLFLL 335
 
Name Accession Description Interval E-value
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 1-340 1.43e-84

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 258.99  E-value: 1.43e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033    1 MANNSMKLLFLSSLVMGTILSISSNSWFGVWMGLEINLLSFIPMLTNNKNMMMNESPIKYFIVQAMASTMLLFSIILIQM 80
Cdd:MTH00160   1 MMMNSSKLLFLSTLIMGTLISISSNSWFGAWMGLEINLLSFIPLISNKKNLMSSESSLKYFLIQALASIILLFSIILNML 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033   81 KYTMgweMKIIPSMMISSSLLLKTGAAPFHFWFPEVMSASSWINCLTLMTWQKIAPMMVFSYCIQeTGFIFSITITSIII 160
Cdd:MTH00160  81 NLML---FNNISSMLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYLIN-NNFIIIIIILSAII 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033  161 GALGGLNQTSLRQILAYSSISHLGWMISSLIVSENAWELYFVTYSMLSLIMILLFKQMNLFSVIQIYSASNIKMEVKFMM 240
Cdd:MTH00160 157 GAIGGLNQTSLRKILAYSSINHLGWMLSSMMISENLWLIYFLIYSIISLSIILLFNKFNIFFLNQLFNSNNKSKKIKFLL 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033  241 FLSLLSLGGLPPFLGFLPKWIVMQYLVENNMTILLSIMVLFTTITLYYYMRISFSALIMTYTENSWSLSIKSNRESKSTL 320
Cdd:MTH00160 237 FLNLLSLGGLPPFLGFLPKWIIIQLLISNNMFFLLFILIMSSLITLYFYLRISYSSLMLNYNKNKWNLKKKKNKFSLILN 316

                        330       340
                 ....*....|....*....|
gi 69219033  321 SMaVMISTLGLIATPNLMFL 340
Cdd:MTH00160 317 FL-SFISLFGLILSSLLFLL 335
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 24-279 9.69e-17

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 79.28  E-value: 9.69e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033    24 SNSWFGVWMGLEINLLSFIP-MLTNNKNMMMNESPIKYFIVQAMASTMLLFSIILI--------------QMKYTMGWEM 88
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLlIGYWGKSPRSSEAGMKYFLLTLLGSSILLFGISLMynytgtlsfdelskALTGGLNSSG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033    89 KIIPSMMISSSLLLKTGAAPFHFWFPEVMSASSWINCLTL-MTWQKIAPMMVF-------SYCIQETGFIFSITITSIII 160
Cdd:pfam00361  81 LLLLFLLILVGFLFKSAQVPFHTWLPDAYEGAPTPVSALLaATLVKAGGYGLIrrsllylPSSPFIQQILLILAIISMLL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033   161 GALGGLNQTSLRQILAYSSISHLGWMISSLIV----SENAWELYFVTYSMLSLIMILLF-----KQMNLFSVIQIYSASN 231
Cdd:pfam00361 161 GSLAALVQTDIKRLLAYSSISHMGYMLIALGAgtiyGIQAAIFHLLTHGLFSAGLFLCAgsviyRRVHTRNIRDYGGLAK 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 69219033   232 IKMEVKFMMFLSLLSLGGLPPFLGFLPKWIVMQYLVENNMTILLSIMV 279
Cdd:pfam00361 241 TMPILALVFLVAMLSLAGLPPTAGFLGKFLILAAAVAASWIFLVLAGV 288
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 15-339 5.57e-13

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 69.59  E-value: 5.57e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033    15 VMGTILSISSNSWFGVWMGLEI-NLLSFIPMLTNNKNMMMNESPIKYFIVQAMASTMLLFSIILI----------QMKYT 83
Cdd:TIGR01770 112 LLGIFLLVSSNDLLSIYLGLELqSLCFYVLAGLKRKSRFSTEAGLKYFILGAFSSGLLLFGISLIygftgslnfeDLLLF 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033    84 MGWEMKIIPSM-----MISSSLLLKTGAAPFHFWFPEVMSASSWINCLTLMTWQKIA---PMMVFSYCIQETGFIFSITI 155
Cdd:TIGR01770 192 LSNGMLNISLLllgivLILVGLLFKLSAVPFHMWVPDVYEGAPTPVTAFFSIVPKIAifaVFLRLFLYILFGFSEAWQIF 271

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033   156 TS------IIIGALGGLNQTSLRQILAYSSISHLGWMISSLIVSE----NAWELYFVTYSMLSL---IMILLFKQMNLFS 222
Cdd:TIGR01770 272 LAiiaflsMLIGNFGALAQKKVKRLLAYSSISHVGYILIGLLAGTlegiKAVLFYIFIYALMSLgafGVLSLLRSYKDEW 351

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033   223 VIQIYSASNIKME---VKFMMFLSLLSLGGLPPFLGFLPKWIVMQYLVENNMTILLSIMVLFTTITLYYYMRIsfSALIM 299
Cdd:TIGR01770 352 IEYISDFAGLFKTnpiLAILILIFMFSLAGIPPLAGFFGKFYVFFALLKSGLYWLAVIAVLTSVIGAFYYLRV--VKVMY 429

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 69219033   300 TYTENSWSLSIKSNRESKSTLSMaVMISTLGLIATPNLMF 339
Cdd:TIGR01770 430 FDKPERRIPSNPQSKAQSLLLSI-SALFILFLGLFPSLIL 468
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 8-335 9.18e-12

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 65.52  E-value: 9.18e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033   8 LLFLSSLVmGTILSISSNSWFGVWMGLEINLLSFIPMLT-NNKNMMMNESPIKYFIVQAMASTMLLFSIIL--------- 77
Cdd:COG1007 106 ALLLFATL-GMMLMASANDLLTLFLGLELLSLSLYVLVAfRRDDRRSSEAALKYFLLGALSSGFLLYGISLlygatgsln 184

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033  78 ---IQMKYTMGWEMK---IIPSMMISSSLLLKTGAAPFHFWFPEVMSASSWINCLTLMTWQKIAPMMVFSYCIQETGFIF 151
Cdd:COG1007 185 lagIAAALAAGGANSpllLLGLVLVLAGLAFKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAALLRLLVEAFPGL 264

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033 152 SITITSIII---------GALGGLNQTSLRQILAYSSISHLGWMISSLIV-SENAWE---LYFVTYSMlslimillfkqM 218
Cdd:COG1007 265 AADWQLLLAvlavlsmtvGNLAALAQTNVKRMLAYSSIAHAGYLLLGLAAgTPLGVSaalFYLLAYLF-----------M 333

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033 219 NL--FSVIQIYSASNIKME--------------VKFMMFLSLLSLGGLPPFLGFLPKWIVMQYLVENNMTILLSIMVLFT 282
Cdd:COG1007 334 NLgaFAVILLLSRKGGEAEeiedlaglarrsplLALAMTIFLLSLAGIPPTAGFFGKFYVFSAAVEAGLYWLAVIAVLNS 413

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....
gi 69219033 283 TITLYYYMRIsfsALIMTYTENSWSLSIKSNRESKSTLS-MAVMISTLGLIATP 335
Cdd:COG1007 414 VISAYYYLRV---VKAMYFDEPEEEAPISAPPGLRVALViAALLVLLLGIFPGP 464
 
Name Accession Description Interval E-value
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 1-340 1.43e-84

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 258.99  E-value: 1.43e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033    1 MANNSMKLLFLSSLVMGTILSISSNSWFGVWMGLEINLLSFIPMLTNNKNMMMNESPIKYFIVQAMASTMLLFSIILIQM 80
Cdd:MTH00160   1 MMMNSSKLLFLSTLIMGTLISISSNSWFGAWMGLEINLLSFIPLISNKKNLMSSESSLKYFLIQALASIILLFSIILNML 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033   81 KYTMgweMKIIPSMMISSSLLLKTGAAPFHFWFPEVMSASSWINCLTLMTWQKIAPMMVFSYCIQeTGFIFSITITSIII 160
Cdd:MTH00160  81 NLML---FNNISSMLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYLIN-NNFIIIIIILSAII 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033  161 GALGGLNQTSLRQILAYSSISHLGWMISSLIVSENAWELYFVTYSMLSLIMILLFKQMNLFSVIQIYSASNIKMEVKFMM 240
Cdd:MTH00160 157 GAIGGLNQTSLRKILAYSSINHLGWMLSSMMISENLWLIYFLIYSIISLSIILLFNKFNIFFLNQLFNSNNKSKKIKFLL 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033  241 FLSLLSLGGLPPFLGFLPKWIVMQYLVENNMTILLSIMVLFTTITLYYYMRISFSALIMTYTENSWSLSIKSNRESKSTL 320
Cdd:MTH00160 237 FLNLLSLGGLPPFLGFLPKWIIIQLLISNNMFFLLFILIMSSLITLYFYLRISYSSLMLNYNKNKWNLKKKKNKFSLILN 316

                        330       340
                 ....*....|....*....|
gi 69219033  321 SMaVMISTLGLIATPNLMFL 340
Cdd:MTH00160 317 FL-SFISLFGLILSSLLFLL 335
ND2 MTH00112
NADH dehydrogenase subunit 2; Provisional
 7-338 1.19e-52

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214423 [Multi-domain]  Cd Length: 346  Bit Score: 176.94  E-value: 1.19e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033    7 KLLFLSSLVMGTILSISSNSWFGVWMGLEINLLSFIPMLTNNKNMMMNESPIKYFIVQAMASTMLLFSIIlIQMKYTMGW 86
Cdd:MTH00112   6 KLIITTSLILGTIITISSNHWLMAWTGLEINTLAIIPLISKPHHPRATEAATKYFLTQAAASALILFSST-TNAWNTGQW 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033   87 EMKI----IPSMMISSSLLLKTGAAPFHFWFPEVMSASSWINCLTLMTWQKIAPMMVFSYCIQETGFIFSITI--TSIII 160
Cdd:MTH00112  85 DITQltnpTSCTLLTLALAMKLGLAPFHFWLPEVLQGSTTTTALILSTWQKLAPLTLLLMTSNSLNPTLLLTLaiLSTLI 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033  161 GALGGLNQTSLRQILAYSSISHLGWMISSLIVSENAWELYFVTYSMLSLIMILLFKQMNLFSVIQIYSASNIKMEVKFMM 240
Cdd:MTH00112 165 GGWGGLNQTQLRKIMAFSSIAHLGWMIAIITYSPKLTLLTFYIYILMTTPMFLTLNTTSTKTLKDMMTSWTKSPTLNTTL 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033  241 FLSLLSLGGLPPFLGFLPKWIVMQYLVENNMTILLSIMVLFTTITLYYYMRISFSAlIMTYTENSWSLSIK--SNRESKS 318
Cdd:MTH00112 245 MLTLLSLAGLPPLTGFMPKWLILQELTKQNMTPTATIMAMLSLLSLFFYLRLTYIS-TITLPPNTTNMMMKwrTKPKKNT 323

                        330       340
                 ....*....|....*....|
gi 69219033  319 TLSMAVMISTLGLIATPNLM 338
Cdd:MTH00112 324 LTATLTTLSTLLLPLSPMIL 343
ND2 MTH00041
NADH dehydrogenase subunit 2; Validated
 3-341 1.80e-52

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 177116 [Multi-domain]  Cd Length: 349  Bit Score: 176.66  E-value: 1.80e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033    3 NNSMKLLFLSSLVMGTILSISSNSWFGVWMGLEINLLSFIPMLTNNKNMMMNESPIKYFIVQAMASTMLLFSiILIQMKY 82
Cdd:MTH00041   2 NRNVLIFLITSIILGTIIVISSNHWFLIWLGLELNTLSIIPILSSNFSPRSVEATIKYFLVQAFSAAILLNG-ALIQAWL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033   83 TMGW----EMKIIPSMMISSSLLLKTGAAPFHFWFPEVMSASSWINCLTLMTWQKIAPMMVFSYCIQETGFIFSITITSI 158
Cdd:MTH00041  81 SGSWsingPLNTLSSIIITLALALKLGLAPCHFWFPDVLQGLPFLQGLIIATWQKIAPLILLISISNLLNSNILILCGIL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033  159 --IIGALGGLNQTSLRQILAYSSISHLGWMISSLIVSENAWELYFVTYSMLSLIMILLFKQMNLFSVIQIYSASNIKMEV 236
Cdd:MTH00041 161 svLVGGWGGLNQTQTRKILAFSSIAHLGWIIITSAYSPNASIIMFLIYIIINTSIFLIGNNFSLSTLSHLNKLSQLNPIS 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033  237 KFMMFLSLLSLGGLPPFLGFLPKWIVMQYLVENNMTILLSIMVLFTTITLYYYMRISFSALIMTYTENswSLSIKSNRES 316
Cdd:MTH00041 241 AFLFILSILSLGGLPPLTGFLNKFISLYCLIQNNSILISIILIIGSLLSLFFYLRISFNTSLTLFPQH--SISLFSWRNS 318

                        330       340       350
                 ....*....|....*....|....*....|.
gi 69219033  317 KST------LSMAVMISTLGLIATPNLMFLY 341
Cdd:MTH00041 319 GNItvygviLSILSSISILGLLLIPLFLSFL 349
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
 8-341 2.59e-51

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 173.49  E-value: 2.59e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033    8 LLFLSSLVMGTILSISSNSWFGVWMGLEINLLSFIPMLTNNKNMMMNESPIKYFIVQAMASTMLLFSIIlIQMKYTMGWE 87
Cdd:MTH00105   7 IIIYLTLFLGTMITMISSHWLLAWIGLEMNMLAIIPILMKKHNPRSTEAATKYFLTQATASMLLMMAII-INLMYSGQWT 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033   88 MKIIP----SMMISSSLLLKTGAAPFHFWFPEVMSASSWINCLTLMTWQKIAPMMVFsYCIQE---TGFIFSITITSIII 160
Cdd:MTH00105  86 ITKLTnptaSTLMTIALAMKLGLAPFHFWVPEVTQGIPLSSGMILLTWQKLAPLSIL-YQISPsinPNLLLTLAILSILI 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033  161 GALGGLNQTSLRQILAYSSISHLGWMISSLIVSENAWELYFVTYSMLSLIMILLFKQMNLFSVIQIYSASNIKMEVKFMM 240
Cdd:MTH00105 165 GGWGGLNQTQLRKILAYSSIAHMGWMTAILPYNPTLTLLNLLIYIIMTLTMFMLLMLNSSTTTLSLSHTWNKTPLMTSLI 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033  241 FLSLLSLGGLPPFLGFLPKWIVMQYLVENNMTILLSIMVLFTTITLYYYMRISFS-ALIMTYTENSWSLSIK-SNRESKS 318
Cdd:MTH00105 245 LLTLLSLGGLPPLTGFMPKWMIIQELTKNNNIILPTLMAITALLNLYFYMRLIYStSLTMFPSTNNMKMKWQfENTKPMT 324

                        330       340
                 ....*....|....*....|...
gi 69219033  319 TLSMAVMISTLGLIATPNLMFLY 341
Cdd:MTH00105 325 LLPTLIILSTMLLPLTPMLSILE 347
ND2 MTH00070
NADH dehydrogenase subunit 2; Provisional
 10-341 5.21e-51

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177142 [Multi-domain]  Cd Length: 346  Bit Score: 172.80  E-value: 5.21e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033   10 FLSSLVMGTILSISSNSWFGVWMGLEINLLSFIPMLTNNKNMMMNESPIKYFIVQAMASTMLLFSIiLIQMKYTMGWEMK 89
Cdd:MTH00070   9 LLSSLALGTMITLSSNHWFLAWMGLEINTLAIIPLMTKTHHPRATEAATKYFLTQASASALILFSS-TINAWFTGEWTIM 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033   90 ----IIPSMMISSSLLLKTGAAPFHFWFPEVMSASSWINCLTLMTWQKIAPMMVFSYCIQE--TGFIFSITITSIIIGAL 163
Cdd:MTH00070  88 nmqtPLPTIMLTIALMMKLGIAPFHFWLPEVLQGLDLTTGLILSTWQKLAPMALLIQISHLlnSNLLIIMGLLSTLIGGW 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033  164 GGLNQTSLRQILAYSSISHLGWMISSLIVSENAWELYFVTYSMLSLIMILLFKQMNLFSVIQIYSASNIKMEVKFMMFLS 243
Cdd:MTH00070 168 GGLNQTQLRKIMAYSSIAHLGWMIIILTFSPHLTLLNLLIYLIMTSSMFLMLMNLNSTNINKLSSSWSKNPTLTSMMMLT 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033  244 LLSLGGLPPFLGFLPKWIVMQYLVENNMTILLSIMVLFTTITLYYYMRISFsALIMTYTENSWSLSI--KSNRESKSTLS 321
Cdd:MTH00070 248 LLSLGGLPPTTGFIPKWLILQELTKQNLTTLATLMALSALLSLFFYLRLSY-AMSLTTSPNTSNSKLywRFKNKTNNLLS 326

                        330       340
                 ....*....|....*....|
gi 69219033  322 MAVMISTLGLIATPNLMFLY 341
Cdd:MTH00070 327 LTIILSLMLLPITPTILNLF 346
ND2 MTH00197
NADH dehydrogenase subunit 2; Provisional
 9-313 2.41e-46

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177244 [Multi-domain]  Cd Length: 323  Bit Score: 159.84  E-value: 2.41e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033    9 LFLSSLVMGTILSISSNSWFGVWMGLEINLLSFIPMLTNNKNMMMNESPIKYFIVQAMASTMLLFSIILIQMKYTMgwem 88
Cdd:MTH00197   2 LFLFIIFGGVLFSLSSSNWFLVWIGMELNLIGFIPLLSQNKSITENEGAMKYFLFQEFGSALLLMGGSLSFSNLYL---- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033   89 KIIPSMMISSSLLLKTGAAPFHFWFPEVMSASSWINCLTLMTWQKIAPMMVFSYCIQETGFIFSITITSIIIGALGGLNQ 168
Cdd:MTH00197  78 SLLSVVLVILGLLLKLGAFPFHFWVPSVMESLSWFNCFLLATWQKLAPLLILAFNSSSFMGLLICSVLSSLIGGIGGMNQ 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033  169 TSLRQILAYSSISHLGWMISSLIVSENAWELYFVTYSMLSLIMILLFKQMNLFSVIQIYSASNIKMEVKFMMFLSLLSLG 248
Cdd:MTH00197 158 SNIRQLLAYSSIGHTGWMLMSLVYSPSIFMLYYLIYFVIMFMLFLFLSKNNLSSLNQQYSNPESMSSNLVFLGLSFLSLG 237

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 69219033  249 GLPPFLGFLPKWIVMQYLVENNMTILLSIMVLFTTITLYYYMRISFSALIMTYTENSWSLSIKSN 313
Cdd:MTH00197 238 GLPPLSGFFLKWLILTSLLSSNISLITFMLILSTCFSLYYYLSLAYKSLILSNWMINFLMKINLL 302
ND2 MTH00011
NADH dehydrogenase subunit 2; Validated
 8-302 3.28e-46

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 164587 [Multi-domain]  Cd Length: 330  Bit Score: 159.95  E-value: 3.28e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033    8 LLFLSSLVMGTILSISSNSWFGVWMGLEINLLSFIPMLTNNKNMMMNESPIKYFIVQAMASTMLLFSIILIQMKYTMgwe 87
Cdd:MTH00011   9 FLFSSTMTLGTLMALSSNNWLFLWMGMELNLLSFVPLMTSSKMNQESEAAVKYFLAQALGSGLLLLGMTMMWSFPSL--- 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033   88 MKIIPSMMISSSLLLKTGAAPFHFWFPEVMSASSWINCLTLMTWQKIAPMMV--FSYCIQETGFIFSITITSIIIGALGG 165
Cdd:MTH00011  86 LKNITALMLLVSLMLKLGMAPCHFWFPSVMSSISWTLCLILSTWQKIAPLSIlfFFTSHNILPMMTSMAAMSALAGGLGG 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033  166 LNQTSLRQILAYSSISHLGWMISSLIVSENAWELYFVTYSMLSLIMILLFKQMNLFSVIQIYSASNIKMEVKFMMFLSLL 245
Cdd:MTH00011 166 MNQTQLRPLLAYSSIGHMGWMTMISVFSPSMAILYFMTYIIITTPLMLLFAYLNAFSTKFNSKISSMSQTTSMSLFIMLL 245

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 69219033  246 SLGGLPPFLGFLPKWIVMQYLVENNMTILLSIMVLFTTITLYYYMRISFSALIMTYT 302
Cdd:MTH00011 246 SLGGLPPFTGFMPKLMAIETLTSNSMILILLVLIVGSLMNLFYYLNLIFNFMYLSPT 302
ND2 MTH00200
NADH dehydrogenase subunit 2; Provisional
 6-340 7.93e-46

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177246 [Multi-domain]  Cd Length: 347  Bit Score: 159.36  E-value: 7.93e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033    6 MKLLFLSSLVMGTILSISSNSWFGVWMGLEINLLSFIPMLTNNKNMMMNESPIKYFIVQAMASTMLLFSIILiQMKYTMG 85
Cdd:MTH00200   5 ILPLFILSLGLGTLLTFSSSHWFLIWLGLEINTLAIIPLLIKQHHPRKVEATTKYFIIQATASALLLFGGLL-NAWTSGQ 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033   86 WE----MKIIPSMMISSSLLLKTGAAPFHFWFPEVMSASSWINCLTLMTWQKIAPMMVFS--YCIQETGFIFSITITSII 159
Cdd:MTH00200  84 WGisemLGPLSETLILLALALKLGLAPGHFWVPDVLQGLSLQTGLILSTWQKLAPFALLIqlAPALNSNILLLLGLLSVL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033  160 IGALGGLNQTSLRQILAYSSISHLGWMISSLIVSENAWELYFVTYSMLSLIMILLFKQMNLFSVIQIYSASNIKMEVKFM 239
Cdd:MTH00200 164 VGGWGGLNQTQLRKILAYSSIAHLGWLLSGLVYSPNLALLYLLLYVIITLTVFLLLNLLNSTKINSLSSSKTKNPILSML 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033  240 MFLSLLSLGGLPPFLGFLPKWIVMQYLVENNMTILLSIMVLFTTITLYYYMRISF-SALIMTYTENSWSLSIKSNRESKS 318
Cdd:MTH00200 244 LGLTLLSLGGLPPLTGFFPKWLILQELSKQGLFIYATILLLGSLLSLFFYLRLSYlTLLTLSPNQINMMSSWRTKSNSNL 323

                        330       340
                 ....*....|....*....|..
gi 69219033  319 TLSMAVMISTLGLIATPNLMFL 340
Cdd:MTH00200 324 LVGLLLLLSILGLPLTPQLLFL 345
ND2 MTH00144
NADH dehydrogenase subunit 2; Provisional
 5-332 1.11e-43

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214432 [Multi-domain]  Cd Length: 328  Bit Score: 153.12  E-value: 1.11e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033    5 SMKLLFLSSLVMGTILSISSNSWFGVWMGLEINLLSFIPMLTNNKNMMMNESPIKYFIVQAMASTMLLFSIILIQMKYTM 84
Cdd:MTH00144   4 PSNLLFLFLMVMGTLLSLSSSHWLGVWVGLEINLIGFLPLLVYKKKSSESESVVKYFIIQSLGSSLLIFGSLIMYNLSFS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033   85 GWEMkiipsMMISSSLLLKTGAAPFHFWFPEVMSASSWINCLTLMTWQKIAPMMVFSYCIQETGFIFSITITSII---IG 161
Cdd:MTH00144  84 WFSM-----SLLLLGLCLKLGLFPFHFWVPSVMAGLSWLSCFLLLTWQKVAPLFLLSNFLDLYWLAYLLCVISVLsalVG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033  162 ALGGLNQTSLRQILAYSSISHLGWMISSLIVSENAWELYFVTYSMLSLIMILLFKQMNLFSVIQIYSASNIKMEVKFMMF 241
Cdd:MTH00144 159 SIGGLNQTQVRALLAYSSISHTGWMLVAILHGSWLMWMYFLIYIVSSGFLFFSLWSGDSGSMKDLGSLKPSYKTGLSIIS 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033  242 lSLLSLGGLPPFLGFLPKWIVMQYLVENNMTILLSIMVLFTTITLYYYMRISFSALImtytenSWSLSIKSNRESKSTLS 321
Cdd:MTH00144 239 -LLLSLGGLPPFLGFCSKLLVLISSMESSPLLLILLLLLGSLISLFFYLSVFFSSFL------SSSKSKKSNSSKVLNSS 311

                        330
                 ....*....|.
gi 69219033  322 MAVMISTLGLI 332
Cdd:MTH00144 312 IISLNLLGGLL 322
ND2 MTH00135
NADH dehydrogenase subunit 2; Provisional
 9-340 3.65e-40

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177193 [Multi-domain]  Cd Length: 347  Bit Score: 144.18  E-value: 3.65e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033    9 LFLSSLVMGTILSISSNSWFGVWMGLEINLLSFIPMLTNNKNMMMNESPIKYFIVQAMASTMLLF-SIILIQMkyTMGWE 87
Cdd:MTH00135   8 ILLFSLGLGTTLTFASSHWLLAWMGLEINTLAIIPLMAQHHHPRAVEATTKYFLTQATAAAMILFaSTTNAWL--TGQWD 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033   88 MKI----IPSMMISSSLLLKTGAAPFHFWFPEVMSASSWINCLTLMTWQKIAPMMVFsYCIQETGFIFSITI--TSIIIG 161
Cdd:MTH00135  86 IQQmshpLPTTMITLALALKIGLAPLHFWLPEVLQGLDLTTGLILSTWQKLAPFALI-LQIAPTNPTLLITLglTSTLVG 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033  162 ALGGLNQTSLRQILAYSSISHLGWMISSLIVSENAWELYFVTYSMLSLIMILLFKQMNLFSvIQIYSASNIKMEVKFMMF 241
Cdd:MTH00135 165 GWGGLNQTQLRKILAYSSIAHLGWMILVLQFSPSLTLLALLTYIIMTSSAFLTFKLNSSTK-INTLATSWTKAPALTALT 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033  242 LSLLSLGGLPPFL-GFLPKWIVMQYLVENNMTILLSIMVLFTTITLYYYMRISFSALIMTYTENSWSLSIKSNRESKSTL 320
Cdd:MTH00135 244 PLILLSLGGLPPLtGFMPKWLILQELTKQDLPLTATLAALSALLSLYFYLRLSYAMTLTISPNTLNGTTPWRLPSTQLTL 323

                        330       340
                 ....*....|....*....|..
gi 69219033  321 SMAV-MISTLGLI-ATPNLMFL 340
Cdd:MTH00135 324 PLAIsTTATLMLLpLTPAILAL 345
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 24-279 9.69e-17

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 79.28  E-value: 9.69e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033    24 SNSWFGVWMGLEINLLSFIP-MLTNNKNMMMNESPIKYFIVQAMASTMLLFSIILI--------------QMKYTMGWEM 88
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLlIGYWGKSPRSSEAGMKYFLLTLLGSSILLFGISLMynytgtlsfdelskALTGGLNSSG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033    89 KIIPSMMISSSLLLKTGAAPFHFWFPEVMSASSWINCLTL-MTWQKIAPMMVF-------SYCIQETGFIFSITITSIII 160
Cdd:pfam00361  81 LLLLFLLILVGFLFKSAQVPFHTWLPDAYEGAPTPVSALLaATLVKAGGYGLIrrsllylPSSPFIQQILLILAIISMLL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033   161 GALGGLNQTSLRQILAYSSISHLGWMISSLIV----SENAWELYFVTYSMLSLIMILLF-----KQMNLFSVIQIYSASN 231
Cdd:pfam00361 161 GSLAALVQTDIKRLLAYSSISHMGYMLIALGAgtiyGIQAAIFHLLTHGLFSAGLFLCAgsviyRRVHTRNIRDYGGLAK 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 69219033   232 IKMEVKFMMFLSLLSLGGLPPFLGFLPKWIVMQYLVENNMTILLSIMV 279
Cdd:pfam00361 241 TMPILALVFLVAMLSLAGLPPTAGFLGKFLILAAAVAASWIFLVLAGV 288
ND2 MTH00196
NADH dehydrogenase subunit 2; Provisional
 14-339 1.36e-16

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214453 [Multi-domain]  Cd Length: 365  Bit Score: 79.69  E-value: 1.36e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033   14 LVMGTILSISSNSWFGVWMGLEINLLSFIPMLTNNKNMMMN-ESPIKYFIVQAMASTMLLFSIILI-------------- 78
Cdd:MTH00196   2 VALGILCLISSSNWLSVYLAIELQTLSLFILIAQNRGSGYSaEAGLKYFVLGALSSGLFLFGCALLcgttgglhlsyinl 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033   79 --QMKYTMGWEMKIIPSMMISSSLLLKTGAAPFHFWFPEVMSASSWINCLTLMTWQKIApmmVFSYCIQ---ETGFIFSI 153
Cdd:MTH00196  82 vlNSGQSFSSVSVPIGYLLIIVALLFKLSVAPFHMWAPDVYEGAPTKTTALLAIVPKLG---IFSILVSiglNVNILLIG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033  154 TITSIIIGALGGLNQTSLRQILAYSSISHLGWMISSL----IVSENAWELYFVTYSMLSL--IMILLFKQMNLFSVIQIY 227
Cdd:MTH00196 159 GLFSLFVGAIGALNQTKIKRLLAYSGIGHMGFVLWGIeigsFESIQASLVYLFIYIIMSIcvFSIILALNVYKNLIIEFS 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033  228 SASNIKMEVKFMMFLSLLSLGGLPPFLGFLPKWIVMQYLVENNMTILLSIMVLFTTITLYYYMRIsfsALIMTYTENSWS 307
Cdd:MTH00196 239 GLSRRLPILAITLALTFLSIAGIPPLVGFLGKWLILLSGVVYQYYLIFLLAVFCSVIAGVYYVRI---VKILFFQANSFL 315

                        330       340       350
                 ....*....|....*....|....*....|....*....
gi 69219033  308 LSIKS--NRESKSTLSMAVMIS-----TLGLIATPNLMF 339
Cdd:MTH00196 316 LISTKilKKENKINLRKALLIGfslylILFTILSPNFFF 354
ND2 MTH00199
NADH dehydrogenase subunit 2; Provisional
 14-292 1.78e-15

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177245 [Multi-domain]  Cd Length: 460  Bit Score: 76.98  E-value: 1.78e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033   14 LVMGTILSISSNSWFGVWMGLEINLLS-FIPMLTNNKNMMMNESPIKYFIVQAMASTMLLFSIILIqmkYTMGWEMKI-- 90
Cdd:MTH00199 106 VALGSLLLVSSINWLSIYLAIELQTLTlFILVALKRDSAYSTEAGLKYFVLGAVSSGLFLFGCALL---YGLTGETSIqg 182

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033   91 --------IPSMMISSSLLLKTGAAPFHFWFPEVMSASSWINCLTLMTWQKIApmmVFSYCIQ---ETGFIFSITITSII 159
Cdd:MTH00199 183 insiltgdVGKILITISLLFKLSAAPFHMWAPDVYEGAPTITTALLATVPKIG---VFSILVQigpVTNVVLICAVLSII 259

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033  160 IGALGGLNQTSLRQILAYSSISHLGWMISSLIVSEN----AWELYFVTYSMLSLIMILLFKQMNLFS--VIQIYSASNIK 233
Cdd:MTH00199 260 YGAIGALNQTKIKRLLAYSGIGHMGFILFGVAIGSFesiqASLIYMIIYVIMSICSFSIILSLKLTKglIVEVSGLSRKN 339

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 69219033  234 MEVKFMMFLSLLSLGGLPPFLGFLPKWIVMQYLVENNMTILLSIMVLFTTITLYYYMRI 292
Cdd:MTH00199 340 PVIALTLALTFLSIAGIPPLAGFLSKWLILLSGVSSGYYLICIIAVLSSVIAGVYYVRV 398
PRK05777 PRK05777
NADH-quinone oxidoreductase subunit NuoN;
8-292 2.87e-14

NADH-quinone oxidoreductase subunit NuoN;


Pssm-ID: 235603 [Multi-domain]  Cd Length: 476  Bit Score: 73.32  E-value: 2.87e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033    8 LLFLSSLVmGTILSISSNSWFGVWMGLEI-NLLSFIPMLTNNKNMMMNESPIKYFIVQAMASTMLLFSI----------- 75
Cdd:PRK05777 107 LLVLFALL-GMMVMVSANDLLTLFLGLELlSLPLYALAALRRDRRRSLEAAIKYFVLGALASGFLLYGMsllygatgsls 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033   76 ---ILIQMKYTMGWEMKIIPSM-MISSSLLLKTGAAPFHFWFPEVMSASSWINCLTLMTWQKIAPMMVF---------SY 142
Cdd:PRK05777 186 fagIAKALADGSGNSLLLLFGLvFLLVGLAFKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAVLlrllvvafgGL 265

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033  143 CIQETGFIFSITITSIIIGALGGLNQTSLRQILAYSSISHLGWMISSLI-VSENAWE---LYFVTYSMLSL---IMILLF 215
Cdd:PRK05777 266 SEDWQQVLAIIAIASMLVGNLAALSQTNIKRLLAYSSIAHAGYLLVGLAaGTAEGYSavlFYLLAYLFMTLgafGVISLL 345

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033  216 KQmNLFSVIQIYSASNIKMEVKFMMFLSLLSLGGLP---PFLGFLPKWIVMQYLVENNMTILLSIMVLFTTITLYYYMRI 292
Cdd:PRK05777 346 RR-KGGEAESISDFAGLSKRSPLLAAVMTIFMLSLAgipPTAGFWGKFYVFEAAVEAGLWWLAVIGVLNSAIGAFYYLRV 424
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 15-339 5.57e-13

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 69.59  E-value: 5.57e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033    15 VMGTILSISSNSWFGVWMGLEI-NLLSFIPMLTNNKNMMMNESPIKYFIVQAMASTMLLFSIILI----------QMKYT 83
Cdd:TIGR01770 112 LLGIFLLVSSNDLLSIYLGLELqSLCFYVLAGLKRKSRFSTEAGLKYFILGAFSSGLLLFGISLIygftgslnfeDLLLF 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033    84 MGWEMKIIPSM-----MISSSLLLKTGAAPFHFWFPEVMSASSWINCLTLMTWQKIA---PMMVFSYCIQETGFIFSITI 155
Cdd:TIGR01770 192 LSNGMLNISLLllgivLILVGLLFKLSAVPFHMWVPDVYEGAPTPVTAFFSIVPKIAifaVFLRLFLYILFGFSEAWQIF 271

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033   156 TS------IIIGALGGLNQTSLRQILAYSSISHLGWMISSLIVSE----NAWELYFVTYSMLSL---IMILLFKQMNLFS 222
Cdd:TIGR01770 272 LAiiaflsMLIGNFGALAQKKVKRLLAYSSISHVGYILIGLLAGTlegiKAVLFYIFIYALMSLgafGVLSLLRSYKDEW 351

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033   223 VIQIYSASNIKME---VKFMMFLSLLSLGGLPPFLGFLPKWIVMQYLVENNMTILLSIMVLFTTITLYYYMRIsfSALIM 299
Cdd:TIGR01770 352 IEYISDFAGLFKTnpiLAILILIFMFSLAGIPPLAGFFGKFYVFFALLKSGLYWLAVIAVLTSVIGAFYYLRV--VKVMY 429

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 69219033   300 TYTENSWSLSIKSNRESKSTLSMaVMISTLGLIATPNLMF 339
Cdd:TIGR01770 430 FDKPERRIPSNPQSKAQSLLLSI-SALFILFLGLFPSLIL 468
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 8-335 9.18e-12

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 65.52  E-value: 9.18e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033   8 LLFLSSLVmGTILSISSNSWFGVWMGLEINLLSFIPMLT-NNKNMMMNESPIKYFIVQAMASTMLLFSIIL--------- 77
Cdd:COG1007 106 ALLLFATL-GMMLMASANDLLTLFLGLELLSLSLYVLVAfRRDDRRSSEAALKYFLLGALSSGFLLYGISLlygatgsln 184

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033  78 ---IQMKYTMGWEMK---IIPSMMISSSLLLKTGAAPFHFWFPEVMSASSWINCLTLMTWQKIAPMMVFSYCIQETGFIF 151
Cdd:COG1007 185 lagIAAALAAGGANSpllLLGLVLVLAGLAFKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAALLRLLVEAFPGL 264

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033 152 SITITSIII---------GALGGLNQTSLRQILAYSSISHLGWMISSLIV-SENAWE---LYFVTYSMlslimillfkqM 218
Cdd:COG1007 265 AADWQLLLAvlavlsmtvGNLAALAQTNVKRMLAYSSIAHAGYLLLGLAAgTPLGVSaalFYLLAYLF-----------M 333

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033 219 NL--FSVIQIYSASNIKME--------------VKFMMFLSLLSLGGLPPFLGFLPKWIVMQYLVENNMTILLSIMVLFT 282
Cdd:COG1007 334 NLgaFAVILLLSRKGGEAEeiedlaglarrsplLALAMTIFLLSLAGIPPTAGFFGKFYVFSAAVEAGLYWLAVIAVLNS 413

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....
gi 69219033 283 TITLYYYMRIsfsALIMTYTENSWSLSIKSNRESKSTLS-MAVMISTLGLIATP 335
Cdd:COG1007 414 VISAYYYLRV---VKAMYFDEPEEEAPISAPPGLRVALViAALLVLLLGIFPGP 464
ND2 MTH00198
NADH dehydrogenase subunit 2; Provisional
 16-187 4.69e-08

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214454 [Multi-domain]  Cd Length: 607  Bit Score: 54.48  E-value: 4.69e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033   16 MGTILSISSNSWFGVWMGLEINLLSFIPM---------LTNNKNMMMNESPIKYFIVQAMASTMLLFS------------ 74
Cdd:MTH00198 199 LGGLLLIESANWLTIYLALEFQTLALFILagegsqpgsHFPSPGNTPPESGLKYWILGAMSSGFYLFGcalyfgftgneg 278

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033   75 ---IILIQMKYTMGWEMK--IIPSMMISSSLLLKTGAAPFHFWFPEVMSASSWINCLTLMTWQKIAPMMVFSYCIQETGF 149
Cdd:MTH00198 279 mlgTILSATLETTNIELRqgSLGYLFITVAILFKLAAAPFHMWTPDVYEGAPTPTTALIAIIPKFTVYILLTSLVITSKL 358

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 69219033  150 IFSITITSIIIGALGGLNQTSLRQILAYSSISHLGWMI 187
Cdd:MTH00198 359 LLSVAIISLVVGAFGALNQTRIKRLLAYSGIGHIGFIL 396
HyfB COG0651
Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy ...
 10-292 1.06e-06

Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 440416 [Multi-domain]  Cd Length: 430  Bit Score: 50.15  E-value: 1.06e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033  10 FLSSLVMGTILSISSNSWFGVWMGLEINLLSFIPMLTNNKNMMMNESPIKYFIVQAMASTMLLFSIILIQMKY-TMGWE- 87
Cdd:COG0651 112 LFLLLLAGMNGAFLTGDLFNLFVFFEVMLLASYGLVALGGTKEALRAGLKYLILNLVGSALFLLGVGLLYGATgTLNMAd 191

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033  88 -----------MKIIPSMMISSSLLLKTGAAPFHFWFPEVMS-ASSWINCL--TLMTwqKIAP--MMVFSYCIQETGFIF 151
Cdd:COG0651 192 laarlaeldpgLLLAAFALLLVGFGIKAALFPLHFWLPDAYPaAPSPVSALlsGLLT--KVGVyaILRVLTLLFGADPAL 269

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033 152 SITITSII-------IGALGGLNQTSLRQILAYSSISHLGWMISSL-IVSENAWE--LYFVTYSMLslIMILLFkqMNLF 221
Cdd:COG0651 270 FLGTLLLVlglltmlVGALGALAQRDLKRLLAYSSVSQIGYILLGLgLGTPLGLAgaLFHLLNHAL--AKALLF--LAAG 345

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033 222 SVIQIYSASNI--------KMEV-KFMMFLSLLSLGGLPPFLGFLPKWIVMQYLVENNMTILLSIMVLFTTITLYYYMRI 292
Cdd:COG0651 346 AIERATGTRDLdklgglgkRMPLtAAAFLIGALALAGLPPLSGFVSKWLLLQAALEAGAWLLAAVLLLSSLLTLAYFVRI 425
PRK12650 PRK12650
DUF4040 family protein;
94-192 2.25e-04

DUF4040 family protein;


Pssm-ID: 237158 [Multi-domain]  Cd Length: 962  Bit Score: 43.11  E-value: 2.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033   94 MMISSSLLLKTGAAPFHFWFPEVMSASSWINCL---TLMTWQKIAPMMVFSYCIQET----GFIFSITITSIIIGALGGL 166
Cdd:PRK12650 212 VLIAVAAFTKSAQFPFHFWLPEAMAAITPVSAFlhaAAVVKAGIYLLLRFSPVFHDVavwnWLLIIVGMITALMGAVFAV 291

                         90       100
                 ....*....|....*....|....*.
gi 69219033  167 NQTSLRQILAYSSISHLGWMISSLIV 192
Cdd:PRK12650 292 QKTDLKKLTAYSTVSQLGWIVATIGV 317
PRK08376 PRK08376
putative monovalent cation/H+ antiporter subunit D; Reviewed
 55-187 1.33e-03

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 236252 [Multi-domain]  Cd Length: 521  Bit Score: 40.47  E-value: 1.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 69219033   55 ESPIKYFIVQAMASTMLLFSIILIQMKY---TMGW-EMKIIPSMMISS---------SLLLKTGAAPFHFWFPEVMSAS- 120
Cdd:PRK08376 172 EAGIKYMFVGSLASSMVLLGIALLYGQYgtlNMAYlAVKMSENPTVVAkialalfiaGLAMKSGAVPVHMWLPDAYPAAp 251

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 69219033  121 SWINCLTLMTwqKIAPMM-VFSYCIQETGFIFSITITSIIIGALGGLN----------QTSLRQILAYSSISHLGWMI 187
Cdd:PRK08376 252 SSISAMLLVI--KQAGLYaLARVLFSIYGPAINLATVGWVIIILGCLTmfvgvamavvQKDVKRLLAYHSVSQIGYML 327
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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