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Conserved domains on  [gi|75490699|gb|ABA19229|]
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CARDIF [Homo sapiens]

Protein Classification

protein kinase family protein( domain architecture ID 10172110)

protein kinase family protein containing a Death domain (DD), may catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine and/or tyrosine residues on protein substrates

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CARD_IPS1 cd08811
Caspase activation and recruitment domain (CARD) found in IPS-1; Caspase activation and ...
 3-93 1.49e-46

Caspase activation and recruitment domain (CARD) found in IPS-1; Caspase activation and recruitment domain (CARD) found in IPS-1 (Interferon beta promoter stimulator protein 1), also known as CARDIF, VISA or MAVS. IPS-1 is an adaptor protein that plays an important role in interferon induction in response to viral infection. It is crucial in triggering innate immunity and in developing adaptive immunity against viral pathogens. The CARD of IPS-1 associates with the CARDs of two RNA helicases, RIG-I and MDA5, which bind viral DNA in the cytoplasm during the initial stage of intracellular antiviral response, leading to the induction of type I interferons. In general, CARDs are death domains (DDs) found associated with caspases. They are known to be important in the signaling pathways for apoptosis, inflammation, and host-defense mechanisms. DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including PYRIN and DED (Death Effector Domain). They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes.


:

Pssm-ID: 260073  Cd Length: 92  Bit Score: 157.52  E-value: 1.49e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75490699   3 FAEDKTYKYICRNFSNFCN-VDVVEILPYLPCLTARDQDRLRATCTLSGNRDTLWHLFNTLQRRPGWVEYFIAALRGCEL 81
Cdd:cd08811   1 FAEDKEYKYLRRNMGVFCHdIKVSEIIPYLPCLTRSDRDEILAKKDMSGNRDTAWTLLDHLQRRPGWVEDFIKALRNCEL 80

                        90
                ....*....|..
gi 75490699  82 VDLADEVASVYE 93
Cdd:cd08811  81 GHLADELERVYD 92
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 64-406 7.96e-08

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 55.71  E-value: 7.96e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75490699    64 RRPGWVEYFIAALRGCELVDLADEVASVYESYQPRTSDRPPdplEPPSLPAERPGPPTPAAAHSIPYNSCREKEPSYPMP 143
Cdd:PHA03247 2668 RRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTP---EPAPHALVSATPLPPGPAAARQASPALPAAPAPPAV 2744

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75490699   144 VQETQAPESPGENSEQALQTLSPR-AIPRNPDGGPLESSS--DLAALSPLTSSGHQEKDTELGSTHTAGATSSLTPSR-- 218
Cdd:PHA03247 2745 PAGPATPGGPARPARPPTTAGPPApAPPAAPAAGPPRRLTrpAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAAsp 2824

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75490699   219 -GPVSPSVSFQPLARSTPRASRLP--GPTGSVVSTGTSFSSSSPGLASAGAAEGKQGAESDQAEPIICSSGAEAPANSLP 295
Cdd:PHA03247 2825 aGPLPPPTSAQPTAPPPPPGPPPPslPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQ 2904

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75490699   296 SKVPTTLMPVNTVALKVPANPASVSTVPSKLPTSSKPPGAVPSNALTNPAPSKLPINSTRAGMVPSKVPTSMVLTKVSAS 375
Cdd:PHA03247 2905 PERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAP 2984

                         330       340       350
                  ....*....|....*....|....*....|.
gi 75490699   376 TVPTDGSSRNEETpAAPTPAGATGGSSAWLD 406
Cdd:PHA03247 2985 SREAPASSTPPLT-GHSLSRVSSWASSLALH 3014
 
Name Accession Description Interval E-value
CARD_IPS1 cd08811
Caspase activation and recruitment domain (CARD) found in IPS-1; Caspase activation and ...
 3-93 1.49e-46

Caspase activation and recruitment domain (CARD) found in IPS-1; Caspase activation and recruitment domain (CARD) found in IPS-1 (Interferon beta promoter stimulator protein 1), also known as CARDIF, VISA or MAVS. IPS-1 is an adaptor protein that plays an important role in interferon induction in response to viral infection. It is crucial in triggering innate immunity and in developing adaptive immunity against viral pathogens. The CARD of IPS-1 associates with the CARDs of two RNA helicases, RIG-I and MDA5, which bind viral DNA in the cytoplasm during the initial stage of intracellular antiviral response, leading to the induction of type I interferons. In general, CARDs are death domains (DDs) found associated with caspases. They are known to be important in the signaling pathways for apoptosis, inflammation, and host-defense mechanisms. DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including PYRIN and DED (Death Effector Domain). They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes.


Pssm-ID: 260073  Cd Length: 92  Bit Score: 157.52  E-value: 1.49e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75490699   3 FAEDKTYKYICRNFSNFCN-VDVVEILPYLPCLTARDQDRLRATCTLSGNRDTLWHLFNTLQRRPGWVEYFIAALRGCEL 81
Cdd:cd08811   1 FAEDKEYKYLRRNMGVFCHdIKVSEIIPYLPCLTRSDRDEILAKKDMSGNRDTAWTLLDHLQRRPGWVEDFIKALRNCEL 80

                        90
                ....*....|..
gi 75490699  82 VDLADEVASVYE 93
Cdd:cd08811  81 GHLADELERVYD 92
CARD_2 pfam16739
Caspase recruitment domain; In the probable ATP-dependent RNA helicase DDX58 this CARD domain ...
 5-92 2.71e-19

Caspase recruitment domain; In the probable ATP-dependent RNA helicase DDX58 this CARD domain is found near the N-terminus and interacts with the C-terminal domain.


Pssm-ID: 465251  Cd Length: 93  Bit Score: 82.64  E-value: 2.71e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75490699     5 EDKTYKYICRNFSNF--CNVDVVEILPYLP-CLTARDQDRLRATCTLSGNRDTLWHLFNTLQR--RPGWVEYFIAALRGC 79
Cdd:pfam16739   1 EDDEYRRLLRLFRPRlkDTIKPTEILPHLPeCLTEDDKERIRAETNNKGNTAAAELLLDRLVRsdREGWFRAFLDALRKT 80

                          90
                  ....*....|...
gi 75490699    80 ELVDLADEVASVY 92
Cdd:pfam16739  81 GHDGLAEELEGEY 93
PHA03247 PHA03247
large tegument protein UL36; Provisional
 64-406 7.96e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 55.71  E-value: 7.96e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75490699    64 RRPGWVEYFIAALRGCELVDLADEVASVYESYQPRTSDRPPdplEPPSLPAERPGPPTPAAAHSIPYNSCREKEPSYPMP 143
Cdd:PHA03247 2668 RRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTP---EPAPHALVSATPLPPGPAAARQASPALPAAPAPPAV 2744

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75490699   144 VQETQAPESPGENSEQALQTLSPR-AIPRNPDGGPLESSS--DLAALSPLTSSGHQEKDTELGSTHTAGATSSLTPSR-- 218
Cdd:PHA03247 2745 PAGPATPGGPARPARPPTTAGPPApAPPAAPAAGPPRRLTrpAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAAsp 2824

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75490699   219 -GPVSPSVSFQPLARSTPRASRLP--GPTGSVVSTGTSFSSSSPGLASAGAAEGKQGAESDQAEPIICSSGAEAPANSLP 295
Cdd:PHA03247 2825 aGPLPPPTSAQPTAPPPPPGPPPPslPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQ 2904

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75490699   296 SKVPTTLMPVNTVALKVPANPASVSTVPSKLPTSSKPPGAVPSNALTNPAPSKLPINSTRAGMVPSKVPTSMVLTKVSAS 375
Cdd:PHA03247 2905 PERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAP 2984

                         330       340       350
                  ....*....|....*....|....*....|.
gi 75490699   376 TVPTDGSSRNEETpAAPTPAGATGGSSAWLD 406
Cdd:PHA03247 2985 SREAPASSTPPLT-GHSLSRVSSWASSLALH 3014
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 195-398 8.99e-05

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 45.34  E-value: 8.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75490699   195 HQEKDTELGSTHTAGATSSLTPSRGPVSPSVSFQPLARSTPRASRLPGPTGSVVSTGTSFSSSSPGLASAGAAEGKQGAE 274
Cdd:pfam17823  90 HTPHGTDLSEPATREGAADGAASRALAAAASSSPSSAAQSLPAAIAALPSEAFSAPRAAACRANASAAPRAAIAAASAPH 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75490699   275 SDQAEPIICSSGAEAPANSLPSKVPTTLMPVNTVALKVPANPA----------SVSTVPSKLPTSSKPPGAVPSnALTNP 344
Cdd:pfam17823 170 AASPAPRTAASSTTAASSTTAASSAPTTAASSAPATLTPARGIstaatatghpAAGTALAAVGNSSPAAGTVTA-AVGTV 248

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 75490699   345 APSKLPINSTRAGMVPSKVPTSMVLTKVS-----ASTVPTDGSSRNEETPAAPTPAGAT 398
Cdd:pfam17823 249 TPAALATLAAAAGTVASAAGTINMGDPHArrlspAKHMPSDTMARNPAAPMGAQAQGPI 307
 
Name Accession Description Interval E-value
CARD_IPS1 cd08811
Caspase activation and recruitment domain (CARD) found in IPS-1; Caspase activation and ...
 3-93 1.49e-46

Caspase activation and recruitment domain (CARD) found in IPS-1; Caspase activation and recruitment domain (CARD) found in IPS-1 (Interferon beta promoter stimulator protein 1), also known as CARDIF, VISA or MAVS. IPS-1 is an adaptor protein that plays an important role in interferon induction in response to viral infection. It is crucial in triggering innate immunity and in developing adaptive immunity against viral pathogens. The CARD of IPS-1 associates with the CARDs of two RNA helicases, RIG-I and MDA5, which bind viral DNA in the cytoplasm during the initial stage of intracellular antiviral response, leading to the induction of type I interferons. In general, CARDs are death domains (DDs) found associated with caspases. They are known to be important in the signaling pathways for apoptosis, inflammation, and host-defense mechanisms. DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including PYRIN and DED (Death Effector Domain). They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes.


Pssm-ID: 260073  Cd Length: 92  Bit Score: 157.52  E-value: 1.49e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75490699   3 FAEDKTYKYICRNFSNFCN-VDVVEILPYLPCLTARDQDRLRATCTLSGNRDTLWHLFNTLQRRPGWVEYFIAALRGCEL 81
Cdd:cd08811   1 FAEDKEYKYLRRNMGVFCHdIKVSEIIPYLPCLTRSDRDEILAKKDMSGNRDTAWTLLDHLQRRPGWVEDFIKALRNCEL 80

                        90
                ....*....|..
gi 75490699  82 VDLADEVASVYE 93
Cdd:cd08811  81 GHLADELERVYD 92
CARD_IPS-1_RIG-I cd08789
Caspase activation and recruitment domains (CARDs) found in IPS-1 and RIG-I-like RNA helicases; ...
 5-88 7.66e-31

Caspase activation and recruitment domains (CARDs) found in IPS-1 and RIG-I-like RNA helicases; Caspase activation and recruitment domains (CARDs) found in IPS-1 (Interferon beta promoter stimulator protein 1) and Retinoic acid Inducible Gene I (RIG-I)-like DEAD box helicases. RIG-I-like helicases and IPS-1 play important roles in the induction of interferons in response to viral infection. They are crucial in triggering innate immunity and in developing adaptive immunity against viral pathogens. RIG-I-like helicases, including MDA5 and RIG-I, contain two N-terminal CARD domains and a C-terminal DEAD box RNA helicase domain. They are cytoplasmic RNA helicases that play an important role in host antiviral response by sensing incoming viral RNA. Upon activation, the signal is transferred to downstream pathways via the adaptor molecule IPS-1 (MAVS, VISA, CARDIF), leading to the induction of type I interferons. MDA5 and RIG-I associate with IPS-1 through a CARD-CARD interaction. In general, CARDs are death domains (DDs) found associated with caspases. They are known to be important in the signaling pathways for apoptosis, inflammation, and host-defense mechanisms. DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including PYRIN and DED (Death Effector Domain). They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes.


Pssm-ID: 260057  Cd Length: 91  Bit Score: 115.25  E-value: 7.66e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75490699   5 EDKTYKYICRNFSNFCN-VDVVEILPYLP-CLTARDQDRLRATCTLSGNRDTLWHLFNTLQR--RPGWVEYFIAALRGCE 80
Cdd:cd08789   1 TDDEKQLLQCYRATVERsLDVVYVLPYLTdCLPDEDRERIRAAEENRGNSGAAALLLNTLLQleKEGWFRGFLDALRATG 80

                        90
                ....*....|.
gi 75490699  81 ---LVDLADEV 88
Cdd:cd08789  81 ytgARELIDNW 91
CARD_2 pfam16739
Caspase recruitment domain; In the probable ATP-dependent RNA helicase DDX58 this CARD domain ...
 5-92 2.71e-19

Caspase recruitment domain; In the probable ATP-dependent RNA helicase DDX58 this CARD domain is found near the N-terminus and interacts with the C-terminal domain.


Pssm-ID: 465251  Cd Length: 93  Bit Score: 82.64  E-value: 2.71e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75490699     5 EDKTYKYICRNFSNF--CNVDVVEILPYLP-CLTARDQDRLRATCTLSGNRDTLWHLFNTLQR--RPGWVEYFIAALRGC 79
Cdd:pfam16739   1 EDDEYRRLLRLFRPRlkDTIKPTEILPHLPeCLTEDDKERIRAETNNKGNTAAAELLLDRLVRsdREGWFRAFLDALRKT 80

                          90
                  ....*....|...
gi 75490699    80 ELVDLADEVASVY 92
Cdd:pfam16739  81 GHDGLAEELEGEY 93
PHA03247 PHA03247
large tegument protein UL36; Provisional
 64-406 7.96e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 55.71  E-value: 7.96e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75490699    64 RRPGWVEYFIAALRGCELVDLADEVASVYESYQPRTSDRPPdplEPPSLPAERPGPPTPAAAHSIPYNSCREKEPSYPMP 143
Cdd:PHA03247 2668 RRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTP---EPAPHALVSATPLPPGPAAARQASPALPAAPAPPAV 2744

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75490699   144 VQETQAPESPGENSEQALQTLSPR-AIPRNPDGGPLESSS--DLAALSPLTSSGHQEKDTELGSTHTAGATSSLTPSR-- 218
Cdd:PHA03247 2745 PAGPATPGGPARPARPPTTAGPPApAPPAAPAAGPPRRLTrpAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAAsp 2824

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75490699   219 -GPVSPSVSFQPLARSTPRASRLP--GPTGSVVSTGTSFSSSSPGLASAGAAEGKQGAESDQAEPIICSSGAEAPANSLP 295
Cdd:PHA03247 2825 aGPLPPPTSAQPTAPPPPPGPPPPslPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQ 2904

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75490699   296 SKVPTTLMPVNTVALKVPANPASVSTVPSKLPTSSKPPGAVPSNALTNPAPSKLPINSTRAGMVPSKVPTSMVLTKVSAS 375
Cdd:PHA03247 2905 PERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAP 2984

                         330       340       350
                  ....*....|....*....|....*....|.
gi 75490699   376 TVPTDGSSRNEETpAAPTPAGATGGSSAWLD 406
Cdd:PHA03247 2985 SREAPASSTPPLT-GHSLSRVSSWASSLALH 3014
CARD cd01671
Caspase activation and recruitment domain: a protein-protein interaction domain; Caspase ...
 14-87 3.41e-07

Caspase activation and recruitment domain: a protein-protein interaction domain; Caspase activation and recruitment domains (CARDs) are death domains (DDs) found associated with caspases. Caspases are aspartate-specific cysteine proteases with functions in apoptosis, immune signaling, inflammation, and host-defense mechanisms. In addition to caspases, proteins containing CARDs include adaptor proteins such as RAIDD, CARD9, and RIG-I-like helicases, which can form multiprotein complexes and play important roles in mediating the signals to induce immune and inflammatory responses. In general, DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including PYRIN and DED (Death Effector Domain). They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes.


Pssm-ID: 260018 [Multi-domain]  Cd Length: 79  Bit Score: 47.90  E-value: 3.41e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 75490699  14 RNFSNFCN-VDVVEILPYLP---CLTARDQDRLRATCTlsgNRDTLWHLFNTLQRR-PGWVEYFIAALRGCELVDLADE 87
Cdd:cd01671   3 KNRVELVEdLDVEDILDHLIqkgVLTEEDKEEILSEKT---RQDKARKLLDILPRRgPKAFEVFCEALRETGQPHLAEL 78
PHA03247 PHA03247
large tegument protein UL36; Provisional
 103-498 1.24e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.48  E-value: 1.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75490699   103 PPDPLEPPSLPAERPGPPTPAAAHSIPYNSCREKEPSYPmpvQETQAPESPGENSEQALQTLSPRAIPrnpdggplessS 182
Cdd:PHA03247 2554 PLPPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAP---PQSARPRAPVDDRGDPRGPAPPSPLP-----------P 2619

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75490699   183 DLAALSPLTSSGhQEKDTELGSTHTAGATSSLTPSRGPVSPSVSFQ---------PLARSTPRASRLPGPTGSVVSTGTS 253
Cdd:PHA03247 2620 DTHAPDPPPPSP-SPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPrrarrlgraAQASSPPQRPRRRAARPTVGSLTSL 2698

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75490699   254 FSSSSPGLASAGAAEGKQGAESdqAEPIICSSGAEAPANSL-PSKVPTTLMPVNTVALKVPANPASVSTVPSklPTSSKP 332
Cdd:PHA03247 2699 ADPPPPPPTPEPAPHALVSATP--LPPGPAAARQASPALPAaPAPPAVPAGPATPGGPARPARPPTTAGPPA--PAPPAA 2774

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75490699   333 PGAVPSNALTNPAPSKLPINSTRAGMVPSKVPTSMVLTKVSASTV-----------PTDGSSRNEETPAAPTPAGATGGS 401
Cdd:PHA03247 2775 PAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPpaaspagplppPTSAQPTAPPPPPGPPPPSLPLGG 2854

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75490699   402 SAWLDSSFENRglGSELSKPGVLASQVDSPFSGcFEDLAISASTSLGMGPCHGPEENEYKSEGTFGIHVAENPSIQLLEG 481
Cdd:PHA03247 2855 SVAPGGDVRRR--PPSRSPAAKPAAPARPPVRR-LARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQP 2931

                         410
                  ....*....|....*..
gi 75490699   482 NPGPPADPDGGPRPQAD 498
Cdd:PHA03247 2932 PPPPPPRPQPPLAPTTD 2948
PHA03247 PHA03247
large tegument protein UL36; Provisional
 93-395 9.76e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.78  E-value: 9.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75490699    93 ESYQPRT----SDRPPDPLEPPSLP--AERPGPPTPAAAhSIPYNSCREKEPSYPMPVQETQAPESPGENSEQALQTLSP 166
Cdd:PHA03247 2594 QSARPRApvddRGDPRGPAPPSPLPpdTHAPDPPPPSPS-PAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGR 2672

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75490699   167 RAIPRNPDGGPLESSSDlAALSPLTSSGH---QEKDTELGSTHTAGAT--SSLTPSRGPVSPSVSFQPLARSTPRASRLP 241
Cdd:PHA03247 2673 AAQASSPPQRPRRRAAR-PTVGSLTSLADpppPPPTPEPAPHALVSATplPPGPAAARQASPALPAAPAPPAVPAGPATP 2751

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75490699   242 GPTGSVVSTGTSFSSSSPGlASAGAAEGKQGAESDQAEPIICSSGAEAPANSLPSKVPTTLMPVNTvALKVPANPAS-VS 320
Cdd:PHA03247 2752 GGPARPARPPTTAGPPAPA-PPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAA-ALPPAASPAGpLP 2829

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75490699   321 TVPSKLPTSSKPPGAVPSNALT--------------NPAPSKLPINSTRAGMVPSKVPTSMVLTKVSASTVPTDGSSRnE 386
Cdd:PHA03247 2830 PPTSAQPTAPPPPPGPPPPSLPlggsvapggdvrrrPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPER-P 2908


                  ....*....
gi 75490699   387 ETPAAPTPA 395
Cdd:PHA03247 2909 PQPQAPPPP 2917
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
233-406 1.82e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 47.54  E-value: 1.82e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75490699  233 STPRASRLPGPTGSVVSTGTSFSSSSPGLASAGAAEGKQGAESDQAEPIICSSGAEAPANS-----LPSKVPTTLMPVNT 307
Cdd:PRK07003 375 RVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATadrgdDAADGDAPVPAKAN 454

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75490699  308 VALKVPANPASVSTVPSKLP-TSSKPPGAVPSNALTNPAPSKLPINSTRAGMVPSKVPTSMVLTKVSASTVPTDGSSRNE 386
Cdd:PRK07003 455 ARASADSRCDERDAQPPADSgSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPAAAAPPAPEARP 534

                        170       180
                 ....*....|....*....|
gi 75490699  387 ETPAAPTPAGATGGSSAWLD 406
Cdd:PRK07003 535 PTPAAAAPAARAGGAAAALD 554
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 195-398 8.99e-05

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 45.34  E-value: 8.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75490699   195 HQEKDTELGSTHTAGATSSLTPSRGPVSPSVSFQPLARSTPRASRLPGPTGSVVSTGTSFSSSSPGLASAGAAEGKQGAE 274
Cdd:pfam17823  90 HTPHGTDLSEPATREGAADGAASRALAAAASSSPSSAAQSLPAAIAALPSEAFSAPRAAACRANASAAPRAAIAAASAPH 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75490699   275 SDQAEPIICSSGAEAPANSLPSKVPTTLMPVNTVALKVPANPA----------SVSTVPSKLPTSSKPPGAVPSnALTNP 344
Cdd:pfam17823 170 AASPAPRTAASSTTAASSTTAASSAPTTAASSAPATLTPARGIstaatatghpAAGTALAAVGNSSPAAGTVTA-AVGTV 248

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 75490699   345 APSKLPINSTRAGMVPSKVPTSMVLTKVS-----ASTVPTDGSSRNEETPAAPTPAGAT 398
Cdd:pfam17823 249 TPAALATLAAAAGTVASAAGTINMGDPHArrlspAKHMPSDTMARNPAAPMGAQAQGPI 307
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 82-402 1.54e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 44.78  E-value: 1.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75490699    82 VDLADEVASVYESYQPRTSDRPPDPLEPPSLPAERPGPPTPAAAHSIPYNSCREKEPSYPMPVQETQAPESPGENSeqal 161
Cdd:PHA03307   55 VVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSP---- 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75490699   162 qtlSPRAIPRNPDGGPLESSSDLAALSPLTSSGHQEKDTELGSTHTAGATSSLTPSRGPVSPSVSFqPLARSTPRASRLP 241
Cdd:PHA03307  131 ---APDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEP-PPSTPPAAASPRP 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75490699   242 GPTGSVVstgtSFSSSSPGLASAGAAEGKQGAESDQAEPIICSSGAEAPANSLPSKVPTtlmpvnTVALKVPANPASVST 321
Cdd:PHA03307  207 PRRSSPI----SASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPA------PITLPTRIWEASGWN 276

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75490699   322 VPSKLPTSSKPPGAVPSnaltnPAPSKLPINSTragmVPSKVPTSMVLTKVSAStvPTDGSSRNEETPAAPTPAGATGGS 401
Cdd:PHA03307  277 GPSSRPGPASSSSSPRE-----RSPSPSPSSPG----SGPAPSSPRASSSSSSS--RESSSSSTSSSSESSRGAAVSPGP 345


                  .
gi 75490699   402 S 402
Cdd:PHA03307  346 S 346
PHA03378 PHA03378
EBNA-3B; Provisional
 128-402 4.82e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 43.13  E-value: 4.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75490699  128 IPYNSCREKEPSYPMPVQETQAP-ESPGENSEQALQTLSPRAIPRNPDGGPLESSSDLAALSPLTSSGHQEKDTELGSTh 206
Cdd:PHA03378 599 VPHPSQTPEPPTTQSHIPETSAPrQWPMPLRPIPMRPLRMQPITFNVLVFPTPHQPPQVEITPYKPTWTQIGHIPYQPS- 677

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75490699  207 TAGATSSLTPSRGPVSpsvsFQPLARSTPRASRLPGPTGSVVSTGTSFSSSSPGLASAGAAEGKQGAESDQAEPIICSSG 286
Cdd:PHA03378 678 PTGANTMLPIQWAPGT----MQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGR 753

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75490699  287 AEAPANSLPSKVPTTLMPVNTVALKVPANPASVSTVPSKLPTSSKPPGAVPSNALTnpAPSKLPINSTRAGMVPSKVPTS 366
Cdd:PHA03378 754 ARPPAAAPGRARPPAAAPGAPTPQPPPQAPPAPQQRPRGAPTPQPPPQAGPTSMQL--MPRAAPGQQGPTKQILRQLLTG 831

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 75490699  367 MVLTKVSASTVPTDGSsrnEETPAAPTPAGATGGSS 402
Cdd:PHA03378 832 GVKRGRPSLKKPAALE---RQAAAGPTPSPGSGTSD 864
CARD_MDA5_r2 cd08819
Caspase activation and recruitment domain found in MDA5, second repeat; Caspase activation and ...
 34-87 6.47e-04

Caspase activation and recruitment domain found in MDA5, second repeat; Caspase activation and recruitment domain (CARD) found in MDA5 (melanoma-differentiation-associated gene 5), second repeat. MDA5, also known as IFIH1, contains two N-terminal CARD domains and a C-terminal RNA helicase domain. MDA5 is a cytoplasmic DEAD box RNA helicase that plays an important role in host antiviral response by sensing incoming viral RNA. Upon activation, the signal is transferred to downstream pathways via the adaptor molecule IPS-1 (MAVS, VISA, CARDIF), leading to the induction of type I interferons. Although very similar in sequence, MDA5 recognizes different sets of viruses compared to RIG-I, a related RNA helicase. MDA5 associates with IPS-1 through a CARD-CARD interaction. In general, CARDs are death domains (DDs) found associated with caspases. They are known to be important in the signaling pathways for apoptosis, inflammation, and host-defense mechanisms. DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including PYRIN and DED (Death Effector Domain). They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes.


Pssm-ID: 260078  Cd Length: 92  Bit Score: 38.85  E-value: 6.47e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 75490699  34 LTARDQDRLRATCTLSGNRDTLWHLFNTLQR-RPGWVEYFIAALRGCELVDLADE 87
Cdd:cd08819  33 LTAEDRERILAATENHGNRSGARELLSRIVRqKEGWFSKFLQALRETEHNNLAEE 87
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 93-396 7.23e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 42.37  E-value: 7.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75490699   93 ESYQPRTSDRPPDPLEPPSlpAERPGPPTPAAAHSIPYNScreKEPSYPMPVQETQAPESP-GENSEQALQTLSPRAIPR 171
Cdd:PTZ00449 539 ESDEPKEGGKPGETKEGEV--GKKPGPAKEHKPSKIPTLS---KKPEFPKDPKHPKDPEEPkKPKRPRSAQRPTRPKSPK 613

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75490699  172 NPDGGPLESSSDLAalSPLTSSGHQEKDTELGSTHTAGATSSLTPSRGPVSPSVSFQPLARSTPRASRLPgptgsvvstg 251
Cdd:PTZ00449 614 LPELLDIPKSPKRP--ESPKSPKRPPPPQRPSSPERPEGPKIIKSPKPPKSPKPPFDPKFKEKFYDDYLD---------- 681

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75490699  252 tsfsssspglASAGAAEGKQGAESDQA-EPIICSSGAEAPANslPSKVPTTLMPvntvalKVPANPASVSTvPSKLPTSS 330
Cdd:PTZ00449 682 ----------AAAKSKETKTTVVLDESfESILKETLPETPGT--PFTTPRPLPP------KLPRDEEFPFE-PIGDPDAE 742

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 75490699  331 KPPgavPSNALTNPAPSKLPINSTRAGMVPSKVPTSMVLTK-VSASTVPTDGSSRNEETPA--APTPAG 396
Cdd:PTZ00449 743 QPD---DIEFFTPPEEERTFFHETPADTPLPDILAEEFKEEdIHAETGEPDEAMKRPDSPSehEDKPPG 808
CARD_MDA5_r1 cd08818
Caspase activation and recruitment domain found in MDA5, first repeat; Caspase activation and ...
 24-81 7.34e-04

Caspase activation and recruitment domain found in MDA5, first repeat; Caspase activation and recruitment domain (CARD) found in MDA5 (melanoma-differentiation-associated gene 5), first repeat. MDA5, also known as IFIH1, contains two N-terminal CARD domains and a C-terminal RNA helicase domain. MDA5 is a cytoplasmic DEAD box RNA helicase that plays an important role in host antiviral response by sensing incoming viral RNA. Upon activation, the signal is transferred to downstream pathways via the adaptor molecule IPS-1 (MAVS, VISA, CARDIF), leading to the induction of type I interferons. Although very similar in sequence, MDA5 recognizes different sets of viruses compared to RIG-I, a related RNA helicase. MDA5 associates with IPS-1 through a CARD-CARD interaction. In general, CARDs are death domains (DDs) found associated with caspases. They are known to be important in the signaling pathways for apoptosis, inflammation, and host-defense mechanisms. DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including PYRIN and DED (Death Effector Domain). They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes.


Pssm-ID: 260077  Cd Length: 92  Bit Score: 38.83  E-value: 7.34e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 75490699  24 VVE-ILPYLPCLTARDQDRLRATCTLSGNRDTLWHLFNTLQRRP---GWVEYFIAALR--GCEL 81
Cdd:cd08818  20 VVEpVLDYLHFLSPEQKERIRQKARTEGNLAAADLLIDAVEKGPhppGWFREFVDALEqgGCDL 83
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 98-403 1.40e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 41.70  E-value: 1.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75490699    98 RTSDRPPDPLEPPSLPAERPGPPTPAAAHSIPYNSCREKEPSYPMPVQETQAPESPGENSEQAL---------QTLSPRA 168
Cdd:PHA03307  111 PSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALplsspeetaRAPSSPP 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75490699   169 IPRNPDGGPLESSSDLAALSPLTSSGHQEKDTELGSTHTAGATSSLTPSRGPVSPSVSFQPLARsTPRASRLPGPTGSVV 248
Cdd:PHA03307  191 AEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENE-CPLPRPAPITLPTRI 269

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75490699   249 STGTSFSSSSPGLASAGAAEGKQGAESDQAEPIICSSGAEAPANSLPSKVPTTlmPVNTVA-LKVPANPASVSTVPSKLP 327
Cdd:PHA03307  270 WEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSR--ESSSSStSSSSESSRGAAVSPGPSP 347

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 75490699   328 TSSKPPGAvPSNALTNPAPSKLPINSTRAGMVPSKVPTSMVLTK---VSASTVPTDGSSRNEETPAAPTPAGATGGSSA 403
Cdd:PHA03307  348 SRSPSPSR-PPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRAraaVAGRARRRDATGRFPAGRPRPSPLDAGAASGA 425
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
203-347 1.68e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 41.37  E-value: 1.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75490699  203 GSTHTAGATSSLTPSRGPVS----------PSVSFQPLARSTPRASRLPGPTGSVVSTGTSFSSSSPGLASAGAAEGKQG 272
Cdd:PRK07003 384 GARAAAAVGASAVPAVTAVTgaagaalapkAAAAAAATRAEAPPAAPAPPATADRGDDAADGDAPVPAKANARASADSRC 463

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 75490699  273 AESDqAEPIICSSGAEAPANSLPSKVPTTLMPVNTVALKVPANPASVSTVPSKLPTSSKP-PGAVPSNALTNPAPS 347
Cdd:PRK07003 464 DERD-AQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPaAAAPPAPEARPPTPA 538
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 101-431 2.13e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 40.83  E-value: 2.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75490699  101 DRPPDPLEPPSLPAERPGPPTPAAAHSIPYNSCRE-KEPSYPMPVQETQAPESPGENSEQalqtlSPRAIP---RNPDGg 176
Cdd:PTZ00449 508 DEPPEGPEASGLPPKAPGDKEGEEGEHEDSKESDEpKEGGKPGETKEGEVGKKPGPAKEH-----KPSKIPtlsKKPEF- 581

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75490699  177 PLESSSDLAALSPLTSSghqekdtelgsthtagatSSLTPSRgPVSPSVSFQPLARSTPRASRLPGPTGSVVSTGTSFSS 256
Cdd:PTZ00449 582 PKDPKHPKDPEEPKKPK------------------RPRSAQR-PTRPKSPKLPELLDIPKSPKRPESPKSPKRPPPPQRP 642

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75490699  257 SSPGLASaGAAEGKQGAESDQAEPIICSSGAEAPANSLPSKVPTTLMPVNTVALKVPANPASVSTVPSKLPTSSKPPGAV 336
Cdd:PTZ00449 643 SSPERPE-GPKIIKSPKPPKSPKPPFDPKFKEKFYDDYLDAAAKSKETKTTVVLDESFESILKETLPETPGTPFTTPRPL 721

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75490699  337 PSNALTNPAPSKLPInstragmvpsKVPTSMVLTKVSASTVPTDGSSRNEETPAAPTPAGATGgssawldSSFENRGLGS 416
Cdd:PTZ00449 722 PPKLPRDEEFPFEPI----------GDPDAEQPDDIEFFTPPEEERTFFHETPADTPLPDILA-------EEFKEEDIHA 784

                        330
                 ....*....|....*
gi 75490699  417 ELSKPGVLASQVDSP 431
Cdd:PTZ00449 785 ETGEPDEAMKRPDSP 799
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 112-348 4.89e-03

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 39.52  E-value: 4.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75490699  112 LPAERPGPPTPAAAHSIPYNSCREKEPSYPMPVQEtqapESPGENSEQALQTLSPRA-----------IPRNPDGGPLES 180
Cdd:PLN03209 323 IPSQRVPPKESDAADGPKPVPTKPVTPEAPSPPIE----EEPPQPKAVVPRPLSPYTayedlkpptspIPTPPSSSPASS 398

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75490699  181 SSDLAALSPLTSSGHQEKDTELGSTHTAGATSSlTPSRGPVSPSVSFQPLARSTprasrLPGPTgsvvstgtsfsssSPG 260
Cdd:PLN03209 399 KSVDAVAKPAEPDVVPSPGSASNVPEVEPAQVE-AKKTRPLSPYARYEDLKPPT-----SPSPT-------------APT 459

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75490699  261 LASAGAAEGKQGAESDQAEPIICSSGAEAPANSLPSkvPTTLMPVNTvALKVPANPASVSTVPSKLPTSSKPPGAVPSNA 340
Cdd:PLN03209 460 GVSPSVSSTSSVPAVPDTAPATAATDAAAPPPANMR--PLSPYAVYD-DLKPPTSPSPAAPVGKVAPSSTNEVVKVGNSA 536


                 ....*...
gi 75490699  341 LTNPAPSK 348
Cdd:PLN03209 537 PPTALADE 544
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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