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Conserved domains on  [gi|124302198|gb|ABN05283|]
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myosin, heavy chain 7, cardiac muscle, beta [Homo sapiens]

Protein Classification

kinesin family protein; kinesin/myosin motor domain-containing protein( domain architecture ID 13414256)

kinesin family protein is a microtubule-dependent molecular motor that plays an important role in intracellular transport and in cell division and has ATPase-containing motor domain; similar to carboxy-terminal kinesins that contains a C-terminal domain responsible for the motor activity (it hydrolyzes ATP and binds microtubules); kinesin/myosin motor domain-containing protein may have ATPase activity and function as a molecular motor, such as kinesins and myosins

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MYSc_Myh7 cd14917
class II myosin heavy chain 7, motor domain; Myosin motor domain of beta (or slow) type I ...
99-766 0e+00

class II myosin heavy chain 7, motor domain; Myosin motor domain of beta (or slow) type I cardiac muscle myosin heavy chain 7 (also called CMH1, MPD1, and CMD1S). Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. It is expressed predominantly in normal human ventrical and in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


:

Pssm-ID: 276881 [Multi-domain]  Cd Length: 668  Bit Score: 1387.51  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd14917     1 PAVLYNLKERYASWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  179 ESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQSPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKL 258
Cdd:cd14917    81 ESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQTPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  259 ASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDAEELMATDNAFDV 338
Cdd:cd14917   161 ASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDAEELMATDNAFDV 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  339 LGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQ 418
Cdd:cd14917   241 LGFTSEEKNSMYKLTGAIMHFGNMKFKQKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQ 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  419 QVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQ 498
Cdd:cd14917   321 QVIYATGALAKAVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQ 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  499 EEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSANFQKPRNIKGKPEAHFS 578
Cdd:cd14917   401 EEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSNNFQKPRNIKGKPEAHFS 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  579 LIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADAPIEKGKGKAKKGSSFQTVSALHRENLNKL 658
Cdd:cd14917   481 LIHYAGTVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSNLFANYAGADAPIEKGKGKAKKGSSFQTVSALHRENLNKL 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  659 MTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFIDS 738
Cdd:cd14917   561 MTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFIDS 640
                         650       660
                  ....*....|....*....|....*...
gi 124302198  739 RKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd14917   641 RKGAEKLLSSLDIDHNQYKFGHTKVFFK 668
COG5022 super family cl34868
Myosin heavy chain [General function prediction only];
37-1432 0e+00

Myosin heavy chain [General function prediction only];


The actual alignment was detected with superfamily member COG5022:

Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 855.91  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   37 VFVPDDKQEFVKAKIVSRE--GGKVTAE--TEYGKTVTVKEDQVMQ--QNPPKFDKIEDMAMLTFLHEPAVLYNLKDRYG 110
Cdd:COG5022    12 CWIPDEEKGWIWAEIIKEAfnKGKVTEEgkKEDGESVSVKKKVLGNdrIKLPKFDGVDDLTELSYLNEPAVLHNLEKRYN 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  111 SWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKR 190
Cdd:COG5022    92 NGQIYTYSGLVLIAVNPYRDLGIYTDDIIQSYSGKNRLELEPHVFAIAEEAYRNLLSEKENQTIIISGESGAGKTENAKR 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  191 VIQYFAVIAAIgdrskkdQSPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEK 270
Cdd:COG5022   172 IMQYLASVTSS-------STVEISSIEKQILATNPILEAFGNAKTVRNDNSSRFGKYIKIEFDENGEICGAKIETYLLEK 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  271 SRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNnPYDYAFISQGE-TTVASIDDAEELMATDNAFDVLGFTSEEKNSM 349
Cdd:COG5022   245 SRVVHQNKNERNYHIFYQLLAGDPEELKKLLLLQN-PKDYIYLSQGGcDKIDGIDDAKEFKITLDALKTIGIDEEEQDQI 323
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  350 YKLTGAIMHFGNMKFKlKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQQVIYATGALAK 429
Cdd:COG5022   324 FKILAAILHIGNIEFK-EDRNGAAIFSDNSVLDKACYLLGIDPSLFVKWLVKRQIKTGGEWIVVPLNLEQALAIRDSLAK 402
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  430 AVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWT 509
Cdd:COG5022   403 ALYSNLFDWIVDRINKSLDHSAAASNFIGVLDIYGFEIFEKNSFEQLCINYTNEKLQQFFNQHMFKLEQEEYVKEGIEWS 482
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  510 FIDFgMDLQACIDLIEK--PMGIMSILEEECMFPKATDMTFKAKLFDN-HLGKSANFQKPRNIKGKpeahFSLIHYAGIV 586
Cdd:COG5022   483 FIDY-FDNQPCIDLIEKknPLGILSLLDEECVMPHATDESFTSKLAQRlNKNSNPKFKKSRFRDNK----FVVKHYAGDV 557
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  587 DYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADapiekgkgkakKGSSFQTVSALHRENLNKLMTNLRSTH 666
Cdd:COG5022   558 EYDVEGFLDKNKDPLNDDLLELLKASTNEFVSTLFDDEENIE-----------SKGRFPTLGSRFKESLNSLMSTLNSTQ 626
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  667 PHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFI---DSRKGAE 743
Cdd:COG5022   627 PHYIRCIKPNEEKSPWTFDNQMVLSQLRCCGVLETIRISRAGFPSRWTFDEFVQRYRILSPSKSWTGEYTwkeDTKNAVK 706
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  744 KLLSSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITRIQAQSRGVLARMEYKKLLERRDSLLVIQWNIRAFMG 823
Cdd:COG5022   707 SILEELVIDSSKYQIGNTKVFFKAGVLAALEDMRDAKLDNIATRIQRAIRGRYLRRRYLQALKRIKKIQVIQHGFRLRRL 786
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  824 VKNWPWMKLYFKIKPLLKSAEREKEMASMKEEFTRLKEALEK----SEARRKELEEKMVSLLQE---------------K 884
Cdd:COG5022   787 VDYELKWRLFIKLQPLLSLLGSRKEYRSYLACIIKLQKTIKRekklRETEEVEFSLKAEVLIQKfgrslkakkrfsllkK 866
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  885 NDLQLQVQAEQDNL--------ADAEER----------------------CDQLIKNKIQLE--AKVKEMNE--RLEDEE 930
Cdd:COG5022   867 ETIYLQSAQRVELAerqlqelkIDVKSIsslklvnleleseiielkkslsSDLIENLEFKTEliARLKKLLNniDLEEGP 946
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  931 EMNAELTAKKRKLEDECSELKRDIDDLELTLakveKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQ----- 1005
Cdd:COG5022   947 SIEYVKLPELNKLHEVESKLKETSEEYEDLL----KKSTILVREGNKANSELKNFKKELAELSKQYGALQESTKQlkelp 1022
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1006 -ALDDLQAEEDKVNTLTKAKvKLEQQVDDLEGSLEQEKK------VRMDLERAKRKLEGDLKLTQESIMDLEN-----DK 1073
Cdd:COG5022  1023 vEVAELQSASKIISSESTEL-SILKPLQKLKGLLLLENNqlqaryKALKLRRENSLLDDKQLYQLESTENLLKtinvkDL 1101
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1074 QQLDERLKKKDFELNAL------NARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEIS 1147
Cdd:COG5022  1102 EVTNRNLVKPANVLQFIvaqmikLNLLQEISKFLSQLVNTLEPVFQKLSVLQLELDGLFWEANLEALPSPPPFAALSEKR 1181
                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1148 ER----LEEAGGATSVQIEMNK-KREAEFQKMRRDLEEatlqheataaalrkkhADSVAELGEQIDNLQRVKQKLEKEKS 1222
Cdd:COG5022  1182 LYqsalYDEKSKLSSSEVNDLKnELIALFSKIFSGWPR----------------GDKLKKLISEGWVPTEYSTSLKGFNN 1245
                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1223 EFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQ--RAKLQTENGELSRQLDEKEALISQ 1300
Cdd:COG5022  1246 LNKKFDTPASMSNEKLLSLLNSIDNLLSSYKLEEEVLPATINSLLQYINVGLFNalRTKASSLRWKSATEVNYNSEELDD 1325
                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1301 LTRgkltyTQQLEDLKRQLE---EEVKAKNALAHALQSARHDCDLLREQYEEETEA-KAELQRVLSKANSEvAQWRTKYE 1376
Cdd:COG5022  1326 WCR-----EFEISDVDEELEeliQAVKVLQLLKDDLNKLDELLDACYSLNPAEIQNlKSRYDPADKENNLP-KEILKKIE 1399
                        1450      1460      1470      1480      1490
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 124302198 1377 TDAIQRTEELE-EAKKKLAQRLQE-AEEAVEAVNAKCSSLEKTKhRLQNEIEDLMVDV 1432
Cdd:COG5022  1400 ALLIKQELQLSlEGKDETEVHLSEiFSEEKSLISLDRNSIYKEE-VLSSLSALLTKEK 1456
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
1173-1930 9.63e-33

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 139.42  E-value: 9.63e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1173 KMRRdlEEATLQHEATAAALrKKHADSVAELGEQIDNLQRVKQK----LEKEKSEFKLELDDVTSNMEQIIKAKANLEKM 1248
Cdd:TIGR02168  171 KERR--KETERKLERTRENL-DRLEDILNELERQLKSLERQAEKaeryKELKAELRELELALLVLRLEELREELEELQEE 247
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1249 CRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEevkAKNA 1328
Cdd:TIGR02168  248 LKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEE---LEAQ 324
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1329 LAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRtkyetDAIQRTEELEEAKKKLAQRLQEAEEAVEAVN 1408
Cdd:TIGR02168  325 LEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELE-----ELESRLEELEEQLETLRSKVAQLELQIASLN 399
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1409 AKCSSLEKTKHRLQNEIEDLMVDVE--RSNAAAAALDKKQRNF---DKILAEWKQKYEESQSELESSQKEARSLSTELFK 1483
Cdd:TIGR02168  400 NEIERLEARLERLEDRRERLQQEIEelLKKLEEAELKELQAELeelEEELEELQEELERLEEALEELREELEEAEQALDA 479
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1484 LKN----------AYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEA---EKME------LQSAL 1544
Cdd:TIGR02168  480 AERelaqlqarldSLERLQENLEGFSEGVKALLKNQSGLSGILGVLSELISVDEGYEAAIEAalgGRLQavvvenLNAAK 559
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1545 EEAEASLEHEEGK--------ILRAQLEFN--QIKAEIERKLAEKDEEMEQAKR---------NHLRVVDSLQTSLDAET 1605
Cdd:TIGR02168  560 KAIAFLKQNELGRvtflpldsIKGTEIQGNdrEILKNIEGFLGVAKDLVKFDPKlrkalsyllGGVLVVDDLDNALELAK 639
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1606 RSRNEALRVKKkmEGDL-----------NEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIV 1674
Cdd:TIGR02168  640 KLRPGYRIVTL--DGDLvrpggvitggsAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQL 717
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1675 -------ERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQE 1747
Cdd:TIGR02168  718 rkeleelSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEE 797
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1748 CRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKgGKKQLQKLEARVRELENELE 1827
Cdd:TIGR02168  798 LKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIES-LAAEIEELEELIEELESELE 876
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1828 AEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFR-KVQHELDEA 1906
Cdd:TIGR02168  877 ALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSeEYSLTLEEA 956
                          810       820
                   ....*....|....*....|....
gi 124302198  1907 EERADIAESQVNKLRAKSRDIGTK 1930
Cdd:TIGR02168  957 EALENKIEDDEEEARRRLKRLENK 980
 
Name Accession Description Interval E-value
MYSc_Myh7 cd14917
class II myosin heavy chain 7, motor domain; Myosin motor domain of beta (or slow) type I ...
99-766 0e+00

class II myosin heavy chain 7, motor domain; Myosin motor domain of beta (or slow) type I cardiac muscle myosin heavy chain 7 (also called CMH1, MPD1, and CMD1S). Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. It is expressed predominantly in normal human ventrical and in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276881 [Multi-domain]  Cd Length: 668  Bit Score: 1387.51  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd14917     1 PAVLYNLKERYASWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  179 ESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQSPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKL 258
Cdd:cd14917    81 ESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQTPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  259 ASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDAEELMATDNAFDV 338
Cdd:cd14917   161 ASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDAEELMATDNAFDV 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  339 LGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQ 418
Cdd:cd14917   241 LGFTSEEKNSMYKLTGAIMHFGNMKFKQKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQ 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  419 QVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQ 498
Cdd:cd14917   321 QVIYATGALAKAVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQ 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  499 EEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSANFQKPRNIKGKPEAHFS 578
Cdd:cd14917   401 EEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSNNFQKPRNIKGKPEAHFS 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  579 LIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADAPIEKGKGKAKKGSSFQTVSALHRENLNKL 658
Cdd:cd14917   481 LIHYAGTVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSNLFANYAGADAPIEKGKGKAKKGSSFQTVSALHRENLNKL 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  659 MTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFIDS 738
Cdd:cd14917   561 MTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFIDS 640
                         650       660
                  ....*....|....*....|....*...
gi 124302198  739 RKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd14917   641 RKGAEKLLSSLDIDHNQYKFGHTKVFFK 668
Myosin_head pfam00063
Myosin head (motor domain);
87-766 0e+00

Myosin head (motor domain);


Pssm-ID: 395017 [Multi-domain]  Cd Length: 674  Bit Score: 1081.92  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198    87 IEDMAMLTFLHEPAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYML 166
Cdd:pfam00063    1 VEDMVELSYLNEPSVLHNLKKRYKSDLIYTYSGLVLVAVNPYKQLPIYSEDMIKAYRGKRRGELPPHIFAIADEAYRSML 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   167 TDRENQSILITGESGAGKTVNTKRVIQYFAVIAAIGDRSKkdqspgKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGK 246
Cdd:pfam00063   81 QDKENQSILISGESGAGKTENTKKIMQYLASVSGSGSAGN------VGRLEEQILQSNPILEAFGNAKTVRNNNSSRFGK 154
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   247 FIRIHFGATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITnNPYDYAFISQ-GETTVASIDD 325
Cdd:pfam00063  155 YIEIQFDAKGDIVGGKIETYLLEKSRVVYQAEGERNYHIFYQLLAGASAQLKKELRLT-NPKDYHYLSQsGCYTIDGIDD 233
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   326 AEELMATDNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVK 405
Cdd:pfam00063  234 SEEFKITDKAMDILGFSDEEQMGIFRIVAAILHLGNIEFKKERNDEQAVPDDTENLQKAASLLGIDSTELEKALCKRRIK 313
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   406 VGNEYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATLETKQ-PRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEK 484
Cdd:pfam00063  314 TGRETVSKPQNVEQANYARDALAKAIYSRLFDWLVDRINKSLDVKTiEKASFIGVLDIYGFEIFEKNSFEQLCINYVNEK 393
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   485 LQQFFNHHMFVLEQEEYKKEGIEWTFIDFGmDLQACIDLIE-KPMGIMSILEEECMFPKATDMTFKAKLFDNHlGKSANF 563
Cdd:pfam00063  394 LQQFFNHHMFKLEQEEYVREGIEWTFIDFG-DNQPCIDLIEkKPLGILSLLDEECLFPKATDQTFLDKLYSTF-SKHPHF 471
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   564 QKPRNIKgkpEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADAPIEKGKGKAK---- 639
Cdd:pfam00063  472 QKPRLQG---ETHFIIKHYAGDVEYNVEGFLEKNKDPLNDDLVSLLKSSSDPLLAELFPDYETAESAAANESGKSTpkrt 548
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   640 KGSSFQTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFR 719
Cdd:pfam00063  549 KKKRFITVGSQFKESLGELMKTLNSTNPHYIRCIKPNEKKRAGVFDNSLVLHQLRCNGVLEGIRIRRAGFPNRITFQEFV 628
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....*..
gi 124302198   720 QRYRILNPAAIPEGqFIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:pfam00063  629 QRYRILAPKTWPKW-KGDAKKGCEAILQSLNLDKEEYQFGKTKIFFR 674
MYSc smart00242
Myosin. Large ATPases; ATPase; molecular motor. Muscle contraction consists of a cyclical ...
80-778 0e+00

Myosin. Large ATPases; ATPase; molecular motor. Muscle contraction consists of a cyclical interaction between myosin and actin. The core of the myosin structure is similar in fold to that of kinesin.


Pssm-ID: 214580 [Multi-domain]  Cd Length: 677  Bit Score: 1029.41  E-value: 0e+00
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198     80 NPPKFDKIEDMAMLTFLHEPAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISD 159
Cdd:smart00242    1 NPPKFEGVEDLVLLTYLNEPAVLHNLKKRYLKDLIYTYIGLVLVAVNPYKQLPIYTDEVIKKYRGKSRGELPPHVFAIAD 80
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198    160 NAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFAVIAAigdrskkdQSPGKGTLEDQIIQANPALEAFGNAKTVRND 239
Cdd:smart00242   81 NAYRNMLNDKENQSIIISGESGAGKTENTKKIMQYLASVSG--------SNTEVGSVEDQILESNPILEAFGNAKTLRNN 152
                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198    240 NSSRFGKFIRIHFGATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNnPYDYAFISQGET- 318
Cdd:smart00242  153 NSSRFGKFIEIHFDAKGKIIGAKIETYLLEKSRVVSQAKGERNYHIFYQLLAGASEELKKELGLKS-PEDYRYLNQGGCl 231
                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198    319 TVASIDDAEELMATDNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQA-EPDGTEEADKSAYLMGLNSADLLK 397
Cdd:smart00242  232 TVDGIDDAEEFKETLNAMRVLGFSEEEQESIFKILAAILHLGNIEFEEGRNDNAAsTVKDKEELSNAAELLGVDPEELEK 311
                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198    398 GLCHPRVKVGNEYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLC 477
Cdd:smart00242  312 ALTKRKIKTGGEVITKPLNVEQALDARDALAKALYSRLFDWLVKRINQSLSFKDGSTYFIGVLDIYGFEIFEVNSFEQLC 391
                           410       420       430       440       450       460       470       480
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198    478 INFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGmDLQACIDLIE-KPMGIMSILEEECMFPKATDMTFKAKLfDNH 556
Cdd:smart00242  392 INYANEKLQQFFNQHVFKLEQEEYEREGIDWTFIDFF-DNQDCIDLIEkKPPGILSLLDEECRFPKGTDQTFLEKL-NQH 469
                           490       500       510       520       530       540       550       560
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198    557 LGKSANFQKPRNikgKPEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGadapiekgkg 636
Cdd:smart00242  470 HKKHPHFSKPKK---KGRTEFIIKHYAGDVTYDVTGFLEKNKDTLSDDLIELLQSSKNPLIASLFPSGVS---------- 536
                           570       580       590       600       610       620       630       640
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198    637 KAKKGSSFQTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYG 716
Cdd:smart00242  537 NAGSKKRFQTVGSQFKEQLNELMDTLNSTNPHFIRCIKPNEEKKPGDFDSSLVLHQLRYLGVLENIRIRRAGFPYRLPFD 616
                           650       660       670       680       690       700
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 124302198    717 DFRQRYRILNPAAIPEGQFiDSRKGAEKLLSSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRD 778
Cdd:smart00242  617 EFLQRYRVLLPDTWPPWGG-DAKKACEALLQSLGLDEDEYQLGKTKVFLRPGQLAELEELRE 677
COG5022 COG5022
Myosin heavy chain [General function prediction only];
37-1432 0e+00

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 855.91  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   37 VFVPDDKQEFVKAKIVSRE--GGKVTAE--TEYGKTVTVKEDQVMQ--QNPPKFDKIEDMAMLTFLHEPAVLYNLKDRYG 110
Cdd:COG5022    12 CWIPDEEKGWIWAEIIKEAfnKGKVTEEgkKEDGESVSVKKKVLGNdrIKLPKFDGVDDLTELSYLNEPAVLHNLEKRYN 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  111 SWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKR 190
Cdd:COG5022    92 NGQIYTYSGLVLIAVNPYRDLGIYTDDIIQSYSGKNRLELEPHVFAIAEEAYRNLLSEKENQTIIISGESGAGKTENAKR 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  191 VIQYFAVIAAIgdrskkdQSPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEK 270
Cdd:COG5022   172 IMQYLASVTSS-------STVEISSIEKQILATNPILEAFGNAKTVRNDNSSRFGKYIKIEFDENGEICGAKIETYLLEK 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  271 SRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNnPYDYAFISQGE-TTVASIDDAEELMATDNAFDVLGFTSEEKNSM 349
Cdd:COG5022   245 SRVVHQNKNERNYHIFYQLLAGDPEELKKLLLLQN-PKDYIYLSQGGcDKIDGIDDAKEFKITLDALKTIGIDEEEQDQI 323
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  350 YKLTGAIMHFGNMKFKlKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQQVIYATGALAK 429
Cdd:COG5022   324 FKILAAILHIGNIEFK-EDRNGAAIFSDNSVLDKACYLLGIDPSLFVKWLVKRQIKTGGEWIVVPLNLEQALAIRDSLAK 402
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  430 AVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWT 509
Cdd:COG5022   403 ALYSNLFDWIVDRINKSLDHSAAASNFIGVLDIYGFEIFEKNSFEQLCINYTNEKLQQFFNQHMFKLEQEEYVKEGIEWS 482
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  510 FIDFgMDLQACIDLIEK--PMGIMSILEEECMFPKATDMTFKAKLFDN-HLGKSANFQKPRNIKGKpeahFSLIHYAGIV 586
Cdd:COG5022   483 FIDY-FDNQPCIDLIEKknPLGILSLLDEECVMPHATDESFTSKLAQRlNKNSNPKFKKSRFRDNK----FVVKHYAGDV 557
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  587 DYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADapiekgkgkakKGSSFQTVSALHRENLNKLMTNLRSTH 666
Cdd:COG5022   558 EYDVEGFLDKNKDPLNDDLLELLKASTNEFVSTLFDDEENIE-----------SKGRFPTLGSRFKESLNSLMSTLNSTQ 626
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  667 PHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFI---DSRKGAE 743
Cdd:COG5022   627 PHYIRCIKPNEEKSPWTFDNQMVLSQLRCCGVLETIRISRAGFPSRWTFDEFVQRYRILSPSKSWTGEYTwkeDTKNAVK 706
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  744 KLLSSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITRIQAQSRGVLARMEYKKLLERRDSLLVIQWNIRAFMG 823
Cdd:COG5022   707 SILEELVIDSSKYQIGNTKVFFKAGVLAALEDMRDAKLDNIATRIQRAIRGRYLRRRYLQALKRIKKIQVIQHGFRLRRL 786
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  824 VKNWPWMKLYFKIKPLLKSAEREKEMASMKEEFTRLKEALEK----SEARRKELEEKMVSLLQE---------------K 884
Cdd:COG5022   787 VDYELKWRLFIKLQPLLSLLGSRKEYRSYLACIIKLQKTIKRekklRETEEVEFSLKAEVLIQKfgrslkakkrfsllkK 866
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  885 NDLQLQVQAEQDNL--------ADAEER----------------------CDQLIKNKIQLE--AKVKEMNE--RLEDEE 930
Cdd:COG5022   867 ETIYLQSAQRVELAerqlqelkIDVKSIsslklvnleleseiielkkslsSDLIENLEFKTEliARLKKLLNniDLEEGP 946
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  931 EMNAELTAKKRKLEDECSELKRDIDDLELTLakveKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQ----- 1005
Cdd:COG5022   947 SIEYVKLPELNKLHEVESKLKETSEEYEDLL----KKSTILVREGNKANSELKNFKKELAELSKQYGALQESTKQlkelp 1022
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1006 -ALDDLQAEEDKVNTLTKAKvKLEQQVDDLEGSLEQEKK------VRMDLERAKRKLEGDLKLTQESIMDLEN-----DK 1073
Cdd:COG5022  1023 vEVAELQSASKIISSESTEL-SILKPLQKLKGLLLLENNqlqaryKALKLRRENSLLDDKQLYQLESTENLLKtinvkDL 1101
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1074 QQLDERLKKKDFELNAL------NARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEIS 1147
Cdd:COG5022  1102 EVTNRNLVKPANVLQFIvaqmikLNLLQEISKFLSQLVNTLEPVFQKLSVLQLELDGLFWEANLEALPSPPPFAALSEKR 1181
                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1148 ER----LEEAGGATSVQIEMNK-KREAEFQKMRRDLEEatlqheataaalrkkhADSVAELGEQIDNLQRVKQKLEKEKS 1222
Cdd:COG5022  1182 LYqsalYDEKSKLSSSEVNDLKnELIALFSKIFSGWPR----------------GDKLKKLISEGWVPTEYSTSLKGFNN 1245
                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1223 EFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQ--RAKLQTENGELSRQLDEKEALISQ 1300
Cdd:COG5022  1246 LNKKFDTPASMSNEKLLSLLNSIDNLLSSYKLEEEVLPATINSLLQYINVGLFNalRTKASSLRWKSATEVNYNSEELDD 1325
                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1301 LTRgkltyTQQLEDLKRQLE---EEVKAKNALAHALQSARHDCDLLREQYEEETEA-KAELQRVLSKANSEvAQWRTKYE 1376
Cdd:COG5022  1326 WCR-----EFEISDVDEELEeliQAVKVLQLLKDDLNKLDELLDACYSLNPAEIQNlKSRYDPADKENNLP-KEILKKIE 1399
                        1450      1460      1470      1480      1490
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 124302198 1377 TDAIQRTEELE-EAKKKLAQRLQE-AEEAVEAVNAKCSSLEKTKhRLQNEIEDLMVDV 1432
Cdd:COG5022  1400 ALLIKQELQLSlEGKDETEVHLSEiFSEEKSLISLDRNSIYKEE-VLSSLSALLTKEK 1456
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
845-1923 3.34e-173

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 557.10  E-value: 3.34e-173
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   845 REKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNE 924
Cdd:pfam01576    3 QEEEMQAKEEELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQLQAETELCAEAEEMRARLAARKQELEEILHELES 82
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   925 RLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQ 1004
Cdd:pfam01576   83 RLEEEEERSQQLQNEKKKMQQHIQDLEEQLDEEEAARQKLQLEKVTTEAKIKKLEEDILLLEDQNSKLSKERKLLEERIS 162
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1005 QALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKD 1084
Cdd:pfam01576  163 EFTSNLAEEEEKAKSLSKLKNKHEAMISDLEERLKKEEKGRQELEKAKRKLEGESTDLQEQIAELQAQIAELRAQLAKKE 242
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1085 FELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMN 1164
Cdd:pfam01576  243 EELQAALARLEEETAQKNNALKKIRELEAQISELQEDLESERAARNKAEKQRRDLGEELEALKTELEDTLDTTAAQQELR 322
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1165 KKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKAN 1244
Cdd:pfam01576  323 SKREQEVTELKKALEEETRSHEAQLQEMRQKHTQALEELTEQLEQAKRNKANLEKAKQALESENAELQAELRTLQQAKQD 402
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1245 LEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVK 1324
Cdd:pfam01576  403 SEHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKNIKLSKDVSSLESQLQDTQELLQEETR 482
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1325 AKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAiQRTEELEEAKKKLAQRLQEAEEAV 1404
Cdd:pfam01576  483 QKLNLSTRLRQLEDERNSLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKKLEEDA-GTLEALEEGKKRLQRELEALTQQL 561
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1405 EAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKL 1484
Cdd:pfam01576  562 EEKAAAYDKLEKTKNRLQQELDDLLVDLDHQRQLVSNLEKKQKKFDQMLAEEKAISARYAEERDRAEAEAREKETRALSL 641
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1485 KNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLE 1564
Cdd:pfam01576  642 ARALEEALEAKEELERTNKQLRAEMEDLVSSKDDVGKNVHELERSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVN 721
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1565 FNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVK 1644
Cdd:pfam01576  722 MQALKAQFERDLQARDEQGEEKRRQLVKQVRELEAELEDERKQRAQAVAAKKKLELDLKELEAQIDAANKGREEAVKQLK 801
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1645 SLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLI 1724
Cdd:pfam01576  802 KLQAQMKDLQRELEEARASRDEILAQSKESEKKLKNLEAELLQLQEDLAASERARRQAQQERDELADEIASGASGKSALQ 881
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1725 NQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIA 1804
Cdd:pfam01576  882 DEKRRLEARIAQLEEELEEEQSNTELLNDRLRKSTLQVEQLTTELAAERSTSQKSESARQQLERQNKELKAKLQEMEGTV 961
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1805 LKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEE 1884
Cdd:pfam01576  962 KSKFKSSIAALEAKIAQLEEQLEQESRERQAANKLVRRTEKKLKEVLLQVEDERRHADQYKDQAEKGNSRMKQLKRQLEE 1041
                         1050      1060      1070
                   ....*....|....*....|....*....|....*....
gi 124302198  1885 AEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAK 1923
Cdd:pfam01576 1042 AEEEASRANAARRKLQRELDDATESNESMNREVSTLKSK 1080
PTZ00014 PTZ00014
myosin-A; Provisional
62-819 1.56e-128

myosin-A; Provisional


Pssm-ID: 240229 [Multi-domain]  Cd Length: 821  Bit Score: 424.83  E-value: 1.56e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   62 ETEYGKTVTVKEDQVMQQNPP-KFDKIEDMAMLTFLHEPAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVA 140
Cdd:PTZ00014   72 DPPTNSTFEVKPEHAFNANSQiDPMTYGDIGLLPHTNIPCVLDFLKHRYLKNQIYTTADPLLVAINPFKDLGNTTNDWIR 151
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  141 AYR-GKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFAViAAIGDRSKKDQspgkgtleDQ 219
Cdd:PTZ00014  152 RYRdAKDSDKLPPHVFTTARRALENLHGVKKSQTIIVSGESGAGKTEATKQIMRYFAS-SKSGNMDLKIQ--------NA 222
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  220 IIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLD 299
Cdd:PTZ00014  223 IMAANPVLEAFGNAKTIRNNNSSRFGRFMQLQLGEEGGIRYGSIVAFLLEKSRVVTQEDDERSYHIFYQLLKGANDEMKE 302
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  300 MLLITNNPyDYAFISQGETTVASIDDAEELMATDNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFklKQREEQAEPDGTE 379
Cdd:PTZ00014  303 KYKLKSLE-EYKYINPKCLDVPGIDDVKDFEEVMESFDSMGLSESQIEDIFSILSGVLLLGNVEI--EGKEEGGLTDAAA 379
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  380 EADKS-------AYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATLETKQP 452
Cdd:PTZ00014  380 ISDESlevfneaCELLFLDYESLKKELTVKVTYAGNQKIEGPWSKDESEMLKDSLSKAVYEKLFLWIIRNLNATIEPPGG 459
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  453 RQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGI-----EWTfidfgmDLQACIDLI-EK 526
Cdd:PTZ00014  460 FKVFIGMLDIFGFEVFKNNSLEQLFINITNEMLQKNFVDIVFERESKLYKDEGIsteelEYT------SNESVIDLLcGK 533
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  527 PMGIMSILEEECMFPKATDMTFKAKLFdNHLGKSANFQKPRNIKGKpeaHFSLIHYAGIVDYNIIGWLQKNKDPLNETVV 606
Cdd:PTZ00014  534 GKSVLSILEDQCLAPGGTDEKFVSSCN-TNLKNNPKYKPAKVDSNK---NFVIKHTIGDIQYCASGFLFKNKDVLRPELV 609
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  607 GLYQKSSLKLLSTLFanyagADAPIEKGKGKAKKGSSFQTVsalhrENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDN 686
Cdd:PTZ00014  610 EVVKASPNPLVRDLF-----EGVEVEKGKLAKGQLIGSQFL-----NQLDSLMSLINSTEPHFIRCIKPNENKKPLDWNS 679
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  687 PLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNpAAIPEGQFIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:PTZ00014  680 SKVLIQLHSLSILEALQLRQLGFSYRRTFAEFLSQFKYLD-LAVSNDSSLDPKEKAEKLLERSGLPKDSYAIGKTMVFLK 758
                         730       740       750       760       770
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 124302198  767 AGLLGLLEEMRDERLSR---IITRIQAQSRGVLARmeyKKLLERRDSLLVIQWNIR 819
Cdd:PTZ00014  759 KDAAKELTQIQREKLAAwepLVSVLEALILKIKKK---RKVRKNIKSLVRIQAHLR 811
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
1173-1930 9.63e-33

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 139.42  E-value: 9.63e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1173 KMRRdlEEATLQHEATAAALrKKHADSVAELGEQIDNLQRVKQK----LEKEKSEFKLELDDVTSNMEQIIKAKANLEKM 1248
Cdd:TIGR02168  171 KERR--KETERKLERTRENL-DRLEDILNELERQLKSLERQAEKaeryKELKAELRELELALLVLRLEELREELEELQEE 247
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1249 CRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEevkAKNA 1328
Cdd:TIGR02168  248 LKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEE---LEAQ 324
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1329 LAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRtkyetDAIQRTEELEEAKKKLAQRLQEAEEAVEAVN 1408
Cdd:TIGR02168  325 LEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELE-----ELESRLEELEEQLETLRSKVAQLELQIASLN 399
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1409 AKCSSLEKTKHRLQNEIEDLMVDVE--RSNAAAAALDKKQRNF---DKILAEWKQKYEESQSELESSQKEARSLSTELFK 1483
Cdd:TIGR02168  400 NEIERLEARLERLEDRRERLQQEIEelLKKLEEAELKELQAELeelEEELEELQEELERLEEALEELREELEEAEQALDA 479
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1484 LKN----------AYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEA---EKME------LQSAL 1544
Cdd:TIGR02168  480 AERelaqlqarldSLERLQENLEGFSEGVKALLKNQSGLSGILGVLSELISVDEGYEAAIEAalgGRLQavvvenLNAAK 559
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1545 EEAEASLEHEEGK--------ILRAQLEFN--QIKAEIERKLAEKDEEMEQAKR---------NHLRVVDSLQTSLDAET 1605
Cdd:TIGR02168  560 KAIAFLKQNELGRvtflpldsIKGTEIQGNdrEILKNIEGFLGVAKDLVKFDPKlrkalsyllGGVLVVDDLDNALELAK 639
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1606 RSRNEALRVKKkmEGDL-----------NEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIV 1674
Cdd:TIGR02168  640 KLRPGYRIVTL--DGDLvrpggvitggsAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQL 717
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1675 -------ERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQE 1747
Cdd:TIGR02168  718 rkeleelSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEE 797
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1748 CRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKgGKKQLQKLEARVRELENELE 1827
Cdd:TIGR02168  798 LKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIES-LAAEIEELEELIEELESELE 876
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1828 AEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFR-KVQHELDEA 1906
Cdd:TIGR02168  877 ALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSeEYSLTLEEA 956
                          810       820
                   ....*....|....*....|....
gi 124302198  1907 EERADIAESQVNKLRAKSRDIGTK 1930
Cdd:TIGR02168  957 EALENKIEDDEEEARRRLKRLENK 980
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
840-1672 4.50e-30

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 130.56  E-value: 4.50e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   840 LKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKV 919
Cdd:TIGR02168  218 LKAELRELELALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEI 297
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   920 KEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKAL 999
Cdd:TIGR02168  298 SRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEEL 377
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1000 QEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLEraKRKLEGDLKLTQESIMDLENDKQQLDER 1079
Cdd:TIGR02168  378 EEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELL--KKLEEAELKELQAELEELEEELEELQEE 455
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1080 LKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERT---ARAKVEKLRSDLSRELEEISER------- 1149
Cdd:TIGR02168  456 LERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGfseGVKALLKNQSGLSGILGVLSELisvdegy 535
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1150 ---LEEAGGATSVQIEMNKKREAefqkmrRDLEEATLQHEATAAAL----RKKHADSVAELGEQIDNLQRVKQ---KLEK 1219
Cdd:TIGR02168  536 eaaIEAALGGRLQAVVVENLNAA------KKAIAFLKQNELGRVTFlpldSIKGTEIQGNDREILKNIEGFLGvakDLVK 609
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1220 EKSEFKLEL----------DDVTSNMEQIIKAKANLekMCRTLEDQM-----------NEHRSKAEETQRSVNDLTSQRA 1278
Cdd:TIGR02168  610 FDPKLRKALsyllggvlvvDDLDNALELAKKLRPGY--RIVTLDGDLvrpggvitggsAKTNSSILERRREIEELEEKIE 687
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1279 KLQTENGELSRQLDEKEALISQLtrgkltyTQQLEDLKRQLEEEVKAKNALAHALQSArhdcdllreqyEEETEAKAELQ 1358
Cdd:TIGR02168  688 ELEEKIAELEKALAELRKELEEL-------EEELEQLRKELEELSRQISALRKDLARL-----------EAEVEQLEERI 749
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1359 RVLSKANSEVAQWRTKYEtdaiQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLmvdversNAA 1438
Cdd:TIGR02168  750 AQLSKELTELEAEIEELE----ERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLL-------NEE 818
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1439 AAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGS 1518
Cdd:TIGR02168  819 AANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEE 898
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1519 SGKTIHELEKVRKQLEAEKMELQSALEEAEASLEheegkilRAQLEFNQIKAeierKLAEKDE-EMEQAKRNHLRVVDSL 1597
Cdd:TIGR02168  899 LSEELRELESKRSELRRELEELREKLAQLELRLE-------GLEVRIDNLQE----RLSEEYSlTLEEAEALENKIEDDE 967
                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 124302198  1598 QtsldaETRSRNEALRVKKKMEGDLNEMEIQlshanrmaaEAQKQVKSLQSLLKdtqiQLDDAVRANDDLKENIA 1672
Cdd:TIGR02168  968 E-----EARRRLKRLENKIKELGPVNLAAIE---------EYEELKERYDFLTA----QKEDLTEAKETLEEAIE 1024
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
1310-1928 4.86e-24

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 110.80  E-value: 4.86e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1310 QQLEDLKRQ-----------LEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVaqwrtkyetd 1378
Cdd:COG1196   200 RQLEPLERQaekaeryrelkEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAEL---------- 269
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1379 aiqrtEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQ 1458
Cdd:COG1196   270 -----EELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEE 344
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1459 KYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKM 1538
Cdd:COG1196   345 ELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELE 424
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1539 ELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRsrneaLRVKKKM 1618
Cdd:COG1196   425 ELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAAR-----LLLLLEA 499
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1619 EGDlnemeiqlshanrmAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQaeleelRAVVEQTERS 1698
Cdd:COG1196   500 EAD--------------YEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQ------NIVVEDDEVA 559
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1699 RKLAEQELIETSERVQLLHSqntSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAH 1778
Cdd:COG1196   560 AAAIEYLKAAKAGRATFLPL---DKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAAL 636
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1779 LERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVkgmRKSERRIKELTYQTEEDR 1858
Cdd:COG1196   637 RRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELEL---EEALLAEEEEERELAEAE 713
                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1859 KNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSkfrKVQHELDEAEERADIAESQVNKLRAKSRDIG 1928
Cdd:COG1196   714 EERLEEELEEEALEEQLEAEREELLEELLEEEELLE---EEALEELPEPPDLEELERELERLEREIEALG 780
PTZ00121 PTZ00121
MAEBL; Provisional
841-1435 5.14e-19

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 94.82  E-value: 5.14e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  841 KSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSllQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIqlEAKVK 920
Cdd:PTZ00121 1261 RMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAE--EKKKADEAKKKAEEAKKADEAKKKAEEAKKKA--DAAKK 1336
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  921 EMNERLEDEEEMNAELTAKKRKLEDecSELKRDIDDLEltlaKVEKEKHATENKVKnlTEEMAGLDEIIAKLTKEKKALQ 1000
Cdd:PTZ00121 1337 KAEEAKKAAEAAKAEAEAAADEAEA--AEEKAEAAEKK----KEEAKKKADAAKKK--AEEKKKADEAKKKAEEDKKKAD 1408
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1001 EAHQQALDDLQAEEdkvntlTKAKVKLEQQVDDLEGSLEQEKKVrmdlERAKRKLEGDLKltqesimdLENDKQQLDERL 1080
Cdd:PTZ00121 1409 ELKKAAAAKKKADE------AKKKAEEKKKADEAKKKAEEAKKA----DEAKKKAEEAKK--------AEEAKKKAEEAK 1470
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1081 KKKDFELNALNARIEDEqalgsqLQKKLKELQARIEELEEELEAERTA---RAKVEKLRSDLSRELEEiSERLEEAGGAT 1157
Cdd:PTZ00121 1471 KADEAKKKAEEAKKADE------AKKKAEEAKKKADEAKKAAEAKKKAdeaKKAEEAKKADEAKKAEE-AKKADEAKKAE 1543
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1158 SVQI--EMNKKREAEFQKMRRDLEEATLQHEATAAALRKkhadsvAELGEQIDNlQRVKQKLEKEKSEFKLELDDVTSNM 1235
Cdd:PTZ00121 1544 EKKKadELKKAEELKKAEEKKKAEEAKKAEEDKNMALRK------AEEAKKAEE-ARIEEVMKLYEEEKKMKAEEAKKAE 1616
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1236 EQIIKAkanlekmcrtledqmnEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDL 1315
Cdd:PTZ00121 1617 EAKIKA----------------EELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEA 1680
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1316 KRQLEEEVKAKNALAHALQSARhDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAiQRTEEL---EEAKKK 1392
Cdd:PTZ00121 1681 KKAEEDEKKAAEALKKEAEEAK-KAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDK-KKAEEAkkdEEEKKK 1758
                         570       580       590       600
                  ....*....|....*....|....*....|....*....|...
gi 124302198 1393 LAQRLQEAEEAVEAVNAKCSSLekTKHRLQNEIEDLMVDVERS 1435
Cdd:PTZ00121 1759 IAHLKKEEEKKAEEIRKEKEAV--IEEELDEEDEKRRMEVDKK 1799
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
1128-1907 7.04e-19

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 94.03  E-value: 7.04e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1128 ARAKVEKLRSDLSRELEEISERLEEAGgatsvqiEMNKKREAEFQK----MRRDLEEATLQHEATAAaLRKKHADSVAEL 1203
Cdd:pfam15921   72 GKEHIERVLEEYSHQVKDLQRRLNESN-------ELHEKQKFYLRQsvidLQTKLQEMQMERDAMAD-IRRRESQSQEDL 143
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1204 GEQidnLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLED-----------QMNEHRSKAEETQRSVND 1272
Cdd:pfam15921  144 RNQ---LQNTVHELEAAKCLKEDMLEDSNTQIEQLRKMMLSHEGVLQEIRSilvdfeeasgkKIYEHDSMSTMHFRSLGS 220
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1273 LTSQRAK-LQTENGELSRQL----DEKEALISQLTRGKLTYTQQLEDLKRQL--EEEVKAkNALAHALQSARHDCDLLRE 1345
Cdd:pfam15921  221 AISKILReLDTEISYLKGRIfpveDQLEALKSESQNKIELLLQQHQDRIEQLisEHEVEI-TGLTEKASSARSQANSIQS 299
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1346 QYE----EETEAKAELQRVLSKANSEVAQWRTkyetdaiqrteELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHR- 1420
Cdd:pfam15921  300 QLEiiqeQARNQNSMYMRQLSDLESTVSQLRS-----------ELREAKRMYEDKIEELEKQLVLANSELTEARTERDQf 368
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1421 ------LQNEIEDLMVDV-ERSNAAAAALDKKQRNFDKILAEwKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLE 1493
Cdd:pfam15921  369 sqesgnLDDQLQKLLADLhKREKELSLEKEQNKRLWDRDTGN-SITIDHLRRELDDRNMEVQRLEALLKAMKSECQGQME 447
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1494 -HLETFKRENKNLqEEISDLTEQLGSsgkTIHELEKVRKQLEAEKMELQSA---LEEAEASLEHEEGKILRAQLEFNQIK 1569
Cdd:pfam15921  448 rQMAAIQGKNESL-EKVSSLTAQLES---TKEMLRKVVEELTAKKMTLESSertVSDLTASLQEKERAIEATNAEITKLR 523
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1570 AEIERKLaekdEEMEQAKR--NHLRVVdslQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQ 1647
Cdd:pfam15921  524 SRVDLKL----QELQHLKNegDHLRNV---QTECEALKLQMAEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLE 596
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1648 SLLKDTQIQLDDAVRANDdlKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQElietSERVQLLHSQNTSLiNQK 1727
Cdd:pfam15921  597 KEINDRRLELQEFKILKD--KKDAKIRELEARVSDLELEKVKLVNAGSERLRAVKDIK----QERDQLLNEVKTSR-NEL 669
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1728 KKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEE----LKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAE-- 1801
Cdd:pfam15921  670 NSLSEDYEVLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQtrntLKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQsk 749
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1802 ----QIALKGGKKQLQKLEARVRELENELEA---EQKRNAESVKGMRKSERRIKEltyqteedrkNLLRLQDLVDKLQLK 1874
Cdd:pfam15921  750 iqflEEAMTNANKEKHFLKEEKNKLSQELSTvatEKNKMAGELEVLRSQERRLKE----------KVANMEVALDKASLQ 819
                          810       820       830
                   ....*....|....*....|....*....|...
gi 124302198  1875 VkAYKRQAEEAEEQANTNLskfrKVQHELDEAE 1907
Cdd:pfam15921  820 F-AECQDIIQRQEQESVRL----KLQHTLDVKE 847
PTZ00121 PTZ00121
MAEBL; Provisional
1077-1883 3.17e-18

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 92.13  E-value: 3.17e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1077 DERLK--KKDFELNALNARIEDEQAlgSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAG 1154
Cdd:PTZ00121 1069 DEGLKpsYKDFDFDAKEDNRADEAT--EEAFGKAEEAKKTETGKAEEARKAEEAKKKAEDARKAEEARKAEDARKAEEAR 1146
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1155 GATSVQIEMNKKREAEFQKMR--RDLEEATLQHEA-TAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEfKLELDDV 1231
Cdd:PTZ00121 1147 KAEDAKRVEIARKAEDARKAEeaRKAEDAKKAEAArKAEEVRKAEELRKAEDARKAEAARKAEEERKAEEAR-KAEDAKK 1225
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1232 TSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSvnDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQ 1311
Cdd:PTZ00121 1226 AEAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMA--HFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKK 1303
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1312 LEDLKRQLEEEVKAKNALAHAlQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRteelEEAKK 1391
Cdd:PTZ00121 1304 ADEAKKKAEEAKKADEAKKKA-EEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKK----EEAKK 1378
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1392 KLAQRLQEAEEAVEAVNAKCSSLEktkhrlqneiedlmvdversnaaaaalDKKQRNFDKILAEWKQKyEESQSELESSQ 1471
Cdd:PTZ00121 1379 KADAAKKKAEEKKKADEAKKKAEE---------------------------DKKKADELKKAAAAKKK-ADEAKKKAEEK 1430
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1472 KEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASL 1551
Cdd:PTZ00121 1431 KKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKK 1510
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1552 EHEEGKilRAQlefNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEmeiqlsh 1631
Cdd:PTZ00121 1511 KADEAK--KAE---EAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNM------- 1578
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1632 ANRMAAEAQKQVKSlqsllkdtqiQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSE 1711
Cdd:PTZ00121 1579 ALRKAEEAKKAEEA----------RIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKK 1648
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1712 RVQLLHSQNTSLINQkkkmdADLSQLQTEVEEAVQECRNAEEKAKKAitdaammAEELKKEQDTSAHLERMKKNMEQTIK 1791
Cdd:PTZ00121 1649 AEELKKAEEENKIKA-----AEEAKKAEEDKKKAEEAKKAEEDEKKA-------AEALKKEAEEAKKAEELKKKEAEEKK 1716
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1792 dlqhrldEAEQIalkggKKQLQKLEARVRELENELEaEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKL 1871
Cdd:PTZ00121 1717 -------KAEEL-----KKAEEENKIKAEEAKKEAE-EDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEE 1783
                         810
                  ....*....|..
gi 124302198 1872 QLKVKAYKRQAE 1883
Cdd:PTZ00121 1784 ELDEEDEKRRME 1795
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
1261-1588 5.49e-06

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 51.55  E-value: 5.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1261 SKAEETQRSVNDLTsqRAKLQTENGELSRQLDEKE-----ALISQLTRGKLTYTQQLEDLKRQLEEEV--KAKNALAHAL 1333
Cdd:NF033838   50 SSGNESQKEHAKEV--ESHLEKILSEIQKSLDKRKhtqnvALNKKLSDIKTEYLYELNVLKEKSEAELtsKTKKELDAAF 127
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1334 QSARHDCDLLREQYEEETEAKAELQRvlsKANSEVAQWRTKYETDAIqRTEELEEAKKKLaqRLQEAEEAVEAVNAKCSS 1413
Cdd:NF033838  128 EQFKKDTLEPGKKVAEATKKVEEAEK---KAKDQKEEDRRNYPTNTY-KTLELEIAESDV--EVKKAELELVKEEAKEPR 201
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1414 LEKTkhrlqneIEDLMVDVERSNAAAAALDKKQRnfDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLE 1493
Cdd:NF033838  202 DEEK-------IKQAKAKVESKKAEATRLEKIKT--DREKAEEEAKRRADAKLKEAVEKNVATSEQDKPKRRAKRGVLGE 272
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1494 HLETFKRENKNLQEEISDLTEQLGS----SGKTIHELEK-----------------------VRKQLEAEKMELQSALEE 1546
Cdd:NF033838  273 PATPDKKENDAKSSDSSVGEETLPSpslkPEKKVAEAEKkveeakkkakdqkeedrrnyptnTYKTLELEIAESDVKVKE 352
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 124302198 1547 AEASLEHEEGKILRAQLEFNQIKAEIERKLAE----------KDEEMEQAKR 1588
Cdd:NF033838  353 AELELVKEEAKEPRNEEKIKQAKAKVESKKAEatrlekiktdRKKAEEEAKR 404
F-BAR_PSTPIP2 cd07672
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Proline-Serine-Threonine ...
1232-1424 2.09e-03

The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Proline-Serine-Threonine Phosphatase-Interacting Protein 2; F-BAR domains are dimerization modules that bind and bend membranes and are found in proteins involved in membrane dynamics and actin reorganization. Proline-Serine-Threonine Phosphatase-Interacting Protein 2 (PSTPIP2), also known as Macrophage Actin-associated tYrosine Phosphorylated protein (MAYP), is mostly expressed in hematopoietic cells but is also expressed in the brain. It is involved in regulating cell adhesion and motility. Mutations in the gene encoding murine PSTPIP2 can cause autoinflammatory disorders such as chronic multifocal osteomyelitis and macrophage autoinflammatory disease. PSTPIP2 contains an N-terminal F-BAR domain and lacks the PEST motifs and SH3 domain that are found in PSTPIP1. F-BAR domains form banana-shaped dimers with a positively-charged concave surface that binds to negatively-charged lipid membranes. They can induce membrane deformation in the form of long tubules.


Pssm-ID: 153356 [Multi-domain]  Cd Length: 240  Bit Score: 41.86  E-value: 2.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1232 TSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQ 1311
Cdd:cd07672     4 TGGYDCIIQHLNDGRKNCKEFEDFLKERASIEEKYGKELLNLSKKKPCGQTEINTLKRSLDVFKQQIDNVGQSHIQLAQT 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1312 LEDLKRQLE---EEVKAKNALAHALQSARHDCDLLreQYEEETEAKAEL-QRVLSKANSEVAQWRTKYETDAIQRteelE 1387
Cdd:cd07672    84 LRDEAKKMEdfrERQKLARKKIELIMDAIHKQRAM--QFKKTMESKKNYeQKCRDKDEAEQAVNRNANLVNVKQQ----E 157
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 124302198 1388 EAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNE 1424
Cdd:cd07672   158 KLFAKLAQSKQNAEDADRLYMQNISVLDKIREDWQKE 194
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
902-1043 3.14e-03

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 41.93  E-value: 3.14e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198    902 EERCDQLIKNKIQLEAKVKEMNErleDEEEMNAELTakkrkledECSELKRDIDDLELTL-AKVEKEKHATENKVKNLTE 980
Cdd:smart00787  136 EWRMKLLEGLKEGLDENLEGLKE---DYKLLMKELE--------LLNSIKPKLRDRKDALeEELRQLKQLEDELEDCDPT 204
                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 124302198    981 EMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKK 1043
Cdd:smart00787  205 ELDRAKEKLKKLLQEIMIKVKKLEELEEELQELESKIEDLTNKKSELNTEIAEAEKKLEQCRG 267
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
840-1017 4.04e-03

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 42.31  E-value: 4.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  840 LKSAEREKEmaSMKEEFTRLK-----------EALEKSEARRKELEEKMVSLlQEKNDLQ-------LQVQAEQDNLADA 901
Cdd:NF033838  206 IKQAKAKVE--SKKAEATRLEkiktdrekaeeEAKRRADAKLKEAVEKNVAT-SEQDKPKrrakrgvLGEPATPDKKEND 282
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  902 EERCDQLI-------------KNKIQLEAKVKEMNERLED--EEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEK 966
Cdd:NF033838  283 AKSSDSSVgeetlpspslkpeKKVAEAEKKVEEAKKKAKDqkEEDRRNYPTNTYKTLELEIAESDVKVKEAELELVKEEA 362
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 124302198  967 EKHATENKVKNLTEEMAGLDEIIAKLTK----EKKALQEAHQQAlddlqAEEDKV 1017
Cdd:NF033838  363 KEPRNEEKIKQAKAKVESKKAEATRLEKiktdRKKAEEEAKRKA-----AEEDKV 412
MARTX_Nterm NF012221
MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model ...
1254-1447 4.12e-03

MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model describes the N-terminal 1900 amino acids of MARTX family multifunctional-autoprocessing repeats-in-toxin holotoxins, which contain both repeat regions that facilitate their entry into eukaryotic target cells, and multiple effector domains.


Pssm-ID: 467957 [Multi-domain]  Cd Length: 1848  Bit Score: 42.51  E-value: 4.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1254 DQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEkealISQlTRGKLTYTQQledlkrqleeevkakNALAHAL 1333
Cdd:NF012221 1545 DAVSKHAKQDDAAQNALADKERAEADRQRLEQEKQQQLAA----ISG-SQSQLESTDQ---------------NALETNG 1604
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1334 QSARhdcDLLREQYEEETEAKAELQRVLSKANSEVA-------QWRTKYET---DAIQR---------TEELEEAKKKLA 1394
Cdd:NF012221 1605 QAQR---DAILEESRAVTKELTTLAQGLDALDSQATyagesgdQWRNPFAGgllDRVQEqlddakkisGKQLADAKQRHV 1681
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 124302198 1395 QRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNaaAAALDKKQR 1447
Cdd:NF012221 1682 DNQQKVKDAVAKSEAGVAQGEQNQANAEQDIDDAKADAEKRK--DDALAKQNE 1732
growth_prot_Scy NF041483
polarized growth protein Scy;
1131-1856 5.91e-03

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 41.74  E-value: 5.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1131 KVEKLRSDLSRELEEISERLEEAGGATSVQIEmNKKREAEFQ--KMRRDLEEATLQHEATAAALRKKHADSVAEL----- 1203
Cdd:NF041483   44 QVEVLRAKLHEARRSLASRPAYDGADIGYQAE-QLLRNAQIQadQLRADAERELRDARAQTQRILQEHAEHQARLqaelh 122
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1204 GEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIikaKANLEKMCRTLedqMNEHRSKAE--------ETQRsVNDLTS 1275
Cdd:NF041483  123 TEAVQRRQQLDQELAERRQTVESHVNENVAWAEQL---RARTESQARRL---LDESRAEAEqalaaaraEAER-LAEEAR 195
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1276 QRAKLQTEN--GELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKN--ALAHALQSARHDCDLLREQYEEET 1351
Cdd:NF041483  196 QRLGSEAESarAEAEAILRRARKDAERLLNAASTQAQEATDHAEQLRSSTAAESdqARRQAAELSRAAEQRMQEAEEALR 275
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1352 EAKAELQRVLSKANSEVAQWRTKYETDAIQRTeelEEAKKKLAQRLQEAEEAVEAVNAKCsslEKTKHRLQNEIEDLMVD 1431
Cdd:NF041483  276 EARAEAEKVVAEAKEAAAKQLASAESANEQRT---RTAKEEIARLVGEATKEAEALKAEA---EQALADARAEAEKLVAE 349
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1432 VE---RSNAA---AAALDKKQRNFDKILAEwkqkyeesqselesSQKEARSLStelfklKNAYEESLEHLETFKRENKNL 1505
Cdd:NF041483  350 AAekaRTVAAedtAAQLAKAARTAEEVLTK--------------ASEDAKATT------RAAAEEAERIRREAEAEADRL 409
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1506 QEEISDLTEQLGSSGKtiheleKVRKQLEAEKMELQSaleeaEASLEHEEGKILRAQL--EFNQIKAEIERKLAEKDEEM 1583
Cdd:NF041483  410 RGEAADQAEQLKGAAK------DDTKEYRAKTVELQE-----EARRLRGEAEQLRAEAvaEGERIRGEARREAVQQIEEA 478
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1584 EQAKRNHLRV----VDSLQTSLDAET-RSRNEALRVKKKMEGDLNE-MEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQL 1657
Cdd:NF041483  479 ARTAEELLTKakadADELRSTATAESeRVRTEAIERATTLRRQAEEtLERTRAEAERLRAEAEEQAEEVRAAAERAAREL 558
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1658 -DDAVRANDDLKENIAIVERRnnlLQAELEELRAVVEQT--------ERSRKLAEQEL----IETSERVQLLHSQntsli 1724
Cdd:NF041483  559 rEETERAIAARQAEAAEELTR---LHTEAEERLTAAEEAladaraeaERIRREAAEETerlrTEAAERIRTLQAQ----- 630
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1725 nqkkkMDADLSQLQTE-VEEAVQECRNAEEKAKKAITDAAMMAEELKKE-QDTS--------AHLERMKKNMEQTIKDLQ 1794
Cdd:NF041483  631 -----AEQEAERLRTEaAADASAARAEGENVAVRLRSEAAAEAERLKSEaQESAdrvraeaaAAAERVGTEAAEALAAAQ 705
                         730       740       750       760       770       780       790
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 124302198 1795 H----RLDEAEQIaLKGGKKQLQKLEARVRELENELEAEQKR-----NAESVKGMRKSERRIKELTYQTEE 1856
Cdd:NF041483  706 EeaarRRREAEET-LGSARAEADQERERAREQSEELLASARKrveeaQAEAQRLVEEADRRATELVSAAEQ 775
 
Name Accession Description Interval E-value
MYSc_Myh7 cd14917
class II myosin heavy chain 7, motor domain; Myosin motor domain of beta (or slow) type I ...
99-766 0e+00

class II myosin heavy chain 7, motor domain; Myosin motor domain of beta (or slow) type I cardiac muscle myosin heavy chain 7 (also called CMH1, MPD1, and CMD1S). Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. It is expressed predominantly in normal human ventrical and in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276881 [Multi-domain]  Cd Length: 668  Bit Score: 1387.51  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd14917     1 PAVLYNLKERYASWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  179 ESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQSPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKL 258
Cdd:cd14917    81 ESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQTPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  259 ASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDAEELMATDNAFDV 338
Cdd:cd14917   161 ASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDAEELMATDNAFDV 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  339 LGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQ 418
Cdd:cd14917   241 LGFTSEEKNSMYKLTGAIMHFGNMKFKQKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQ 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  419 QVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQ 498
Cdd:cd14917   321 QVIYATGALAKAVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQ 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  499 EEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSANFQKPRNIKGKPEAHFS 578
Cdd:cd14917   401 EEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSNNFQKPRNIKGKPEAHFS 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  579 LIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADAPIEKGKGKAKKGSSFQTVSALHRENLNKL 658
Cdd:cd14917   481 LIHYAGTVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSNLFANYAGADAPIEKGKGKAKKGSSFQTVSALHRENLNKL 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  659 MTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFIDS 738
Cdd:cd14917   561 MTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFIDS 640
                         650       660
                  ....*....|....*....|....*...
gi 124302198  739 RKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd14917   641 RKGAEKLLSSLDIDHNQYKFGHTKVFFK 668
MYSc_class_II cd01377
class II myosins, motor domain; Myosin motor domain in class II myosins. Class II myosins, ...
99-766 0e+00

class II myosins, motor domain; Myosin motor domain in class II myosins. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. Thus, myosin II has two heads. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276951 [Multi-domain]  Cd Length: 662  Bit Score: 1352.13  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd01377     1 ASVLHNLRERYYSDLIYTYSGLFCVAVNPYKRLPIYTEEVIDKYKGKRREEMPPHIFAIADNAYRNMLQDRENQSILITG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  179 ESGAGKTVNTKRVIQYFAVIAAIGDrSKKDQSPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKL 258
Cdd:cd01377    81 ESGAGKTENTKKVIQYLASVAASSK-KKKESGKKKGTLEDQILQANPILEAFGNAKTVRNNNSSRFGKFIRIHFGSTGKI 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  259 ASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDAEELMATDNAFDV 338
Cdd:cd01377   160 AGADIETYLLEKSRVVRQAKGERNYHIFYQLLSGADPELKEKLLLTGDPSYYFFLSQGELTIDGVDDAEEFKLTDEAFDI 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  339 LGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQ 418
Cdd:cd01377   240 LGFSEEEKMSIFKIVAAILHLGNIKFKQRRREEQAELDGTEEADKAAHLLGVNSSDLLKALLKPRIKVGREWVTKGQNKE 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  419 QVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQ 498
Cdd:cd01377   320 QVVFSVGALAKALYERLFLWLVKRINKTLDTKSKRQYFIGVLDIAGFEIFEFNSFEQLCINYTNEKLQQFFNHHMFVLEQ 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  499 EEYKKEGIEWTFIDFGMDLQACIDLIEKP-MGIMSILEEECMFPKATDMTFKAKLFDNHLGKSANFQKPRniKGKPEAHF 577
Cdd:cd01377   400 EEYKKEGIEWTFIDFGLDLQPTIDLIEKPnMGILSILDEECVFPKATDKTFVEKLYSNHLGKSKNFKKPK--PKKSEAHF 477
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  578 SLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADApieKGKGKAKKGSSFQTVSALHRENLNK 657
Cdd:cd01377   478 ILKHYAGDVEYNIDGWLEKNKDPLNENVVALLKKSSDPLVASLFKDYEESGG---GGGKKKKKGGSFRTVSQLHKEQLNK 554
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  658 LMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFiD 737
Cdd:cd01377   555 LMTTLRSTHPHFVRCIIPNEEKKPGKIDAPLVLHQLRCNGVLEGIRICRKGFPNRIIFAEFKQRYSILAPNAIPKGFD-D 633
                         650       660
                  ....*....|....*....|....*....
gi 124302198  738 SRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd01377   634 GKAACEKILKALQLDPELYRIGNTKVFFK 662
MYSc_Myh3 cd14913
class II myosin heavy chain 3, motor domain; Myosin motor domain of fetal skeletal muscle ...
99-766 0e+00

class II myosin heavy chain 3, motor domain; Myosin motor domain of fetal skeletal muscle myosin heavy chain 3 (MYHC-EMB, MYHSE1, HEMHC, SMHCE) in tetrapods including mammals, lizards, and frogs. This gene is a member of the MYH family and encodes a protein with an IQ domain and a myosin head-like domain. Mutations in this gene have been associated with two congenital contracture (arthrogryposis) syndromes, Freeman-Sheldon syndrome and Sheldon-Hall syndrome. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276878 [Multi-domain]  Cd Length: 668  Bit Score: 1310.81  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd14913     1 PAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  179 ESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQSPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKL 258
Cdd:cd14913    81 ESGAGKTVNTKRVIQYFATIAATGDLAKKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  259 ASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDAEELMATDNAFDV 338
Cdd:cd14913   161 ASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITTNPYDYPFISQGEILVASIDDAEELLATDSAIDI 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  339 LGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQ 418
Cdd:cd14913   241 LGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQTVD 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  419 QVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQ 498
Cdd:cd14913   321 QVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFVLEQ 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  499 EEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSANFQKPRNIKGKPEAHFS 578
Cdd:cd14913   401 EEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKVVKGRAEAHFS 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  579 LIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADAPIEKGKGKAKKGSSFQTVSALHRENLNKL 658
Cdd:cd14913   481 LIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFATADADSGKKKVAKKKGSSFQTVSALFRENLNKL 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  659 MTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFIDS 738
Cdd:cd14913   561 MSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNASAIPEGQFIDS 640
                         650       660
                  ....*....|....*....|....*...
gi 124302198  739 RKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd14913   641 KKACEKLLASIDIDHTQYKFGHTKVFFK 668
MYSc_Myh6 cd14916
class II myosin heavy chain 6, motor domain; Myosin motor domain of alpha (or fast) cardiac ...
99-766 0e+00

class II myosin heavy chain 6, motor domain; Myosin motor domain of alpha (or fast) cardiac muscle myosin heavy chain 6. Cardiac muscle myosin is a hexamer consisting of two heavy chain subunits, two light chain subunits, and two regulatory subunits. This gene encodes the alpha heavy chain subunit of cardiac myosin. Mutations in this gene cause familial hypertrophic cardiomyopathy and atrial septal defect. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276880 [Multi-domain]  Cd Length: 670  Bit Score: 1244.18  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd14916     1 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  179 ESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQS-PGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 257
Cdd:cd14916    81 ESGAGKTVNTKRVIQYFASIAAIGDRSKKENPnANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  258 LASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDAEELMATDNAFD 337
Cdd:cd14916   161 LASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTNNPYDYAFVSQGEVSVASIDDSEELLATDSAFD 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  338 VLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNV 417
Cdd:cd14916   241 VLGFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQSV 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  418 QQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLE 497
Cdd:cd14916   321 QQVYYSIGALAKSVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLE 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  498 QEEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSANFQKPRNIKGKPEAHF 577
Cdd:cd14916   401 QEEYKKEGIEWEFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKASDMTFKAKLYDNHLGKSNNFQKPRNVKGKQEAHF 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  578 SLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADAPIE-KGKGKAKKGSSFQTVSALHRENLN 656
Cdd:cd14916   481 SLVHYAGTVDYNILGWLEKNKDPLNETVVGLYQKSSLKLMATLFSTYASADTGDSgKGKGGKKKGSSFQTVSALHRENLN 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  657 KLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFI 736
Cdd:cd14916   561 KLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFI 640
                         650       660       670
                  ....*....|....*....|....*....|
gi 124302198  737 DSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd14916   641 DSRKGAEKLLGSLDIDHNQYKFGHTKVFFK 670
MYSc_Myh7b cd14927
class II myosin heavy chain 7b, motor domain; Myosin motor domain of cardiac muscle, beta ...
100-766 0e+00

class II myosin heavy chain 7b, motor domain; Myosin motor domain of cardiac muscle, beta myosin heavy chain 7b (also called KIAA1512, dJ756N5.1, MYH14, MHC14). MYH7B is a slow-twitch myosin. Mutations in this gene result in one form of autosomal dominant hearing impairment. Multiple transcript variants encoding different isoforms have been found for this gene. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276953 [Multi-domain]  Cd Length: 676  Bit Score: 1228.28  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  100 AVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGE 179
Cdd:cd14927     2 SVLHNLRRRYSRWMIYTYSGLFCVTVNPYKWLPVYTAPVVAAYKGKRRSEAPPHIYAIADNAYNDMLRNRENQSMLITGE 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  180 SGAGKTVNTKRVIQYFAVIAAIGDR-SKKDQSPGK---GTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGAT 255
Cdd:cd14927    82 SGAGKTVNTKRVIQYFAIVAALGDGpGKKAQFLATktgGTLEDQIIEANPAMEAFGNAKTLRNDNSSRFGKFIRIHFGPT 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  256 GKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDAEELMATDNA 335
Cdd:cd14927   162 GKLASADIDIYLLEKSRVIFQQPGERSYHIYYQILSGKKPELQDMLLVSMNPYDYHFCSQGVTTVDNMDDGEELMATDHA 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  336 FDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQ 415
Cdd:cd14927   242 MDILGFSPDEKYGCYKIVGAIMHFGNMKFKQKQREEQAEADGTESADKAAYLMGVSSADLLKGLLHPRVKVGNEYVTKGQ 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  416 NVQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFV 495
Cdd:cd14927   322 SVEQVVYAVGALAKATYDRMFKWLVSRINQTLDTKLPRQFFIGVLDIAGFEIFEFNSFEQLCINFTNEKLQQFFNHHMFI 401
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  496 LEQEEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSANFQKPR-NIKGKPE 574
Cdd:cd14927   402 LEQEEYKREGIEWVFIDFGLDLQACIDLIEKPLGILSILEEECMFPKASDASFKAKLYDNHLGKSPNFQKPRpDKKRKYE 481
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  575 AHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADA---PIEKGKGKAKKGSSFQTVSALH 651
Cdd:cd14927   482 AHFEVVHYAGVVPYNIVGWLDKNKDPLNETVVAIFQKSQNKLLATLYENYVGSDStedPKSGVKEKRKKAASFQTVSQLH 561
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  652 RENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIP 731
Cdd:cd14927   562 KENLNKLMTNLRATQPHFVRCIIPNETKTPGVMDPFLVLHQLRCNGVLEGIRICRKGFPNRILYADFKQRYRILNPSAIP 641
                         650       660       670
                  ....*....|....*....|....*....|....*
gi 124302198  732 EGQFIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd14927   642 DDKFVDSRKATEKLLGSLDIDHTQYQFGHTKVFFK 676
MYSc_Myh13 cd14923
class II myosin heavy chain 13, motor domain; Myosin motor domain of skeletal muscle myosin ...
99-766 0e+00

class II myosin heavy chain 13, motor domain; Myosin motor domain of skeletal muscle myosin heavy chain 13 (also called MyHC-eo) in mammals, chicken, and green anole. Myh13 is a myosin whose expression is restricted primarily to the extrinsic eye muscles which are specialized for function in eye movement. Class II myosins, also called conventional myosins, are the myosin type responsible for producing muscle contraction in muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276887 [Multi-domain]  Cd Length: 671  Bit Score: 1154.44  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd14923     1 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRDNQSILITG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  179 ESGAGKTVNTKRVIQYFAVIAAIGDRsKKDQSPGK--GTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATG 256
Cdd:cd14923    81 ESGAGKTVNTKRVIQYFATIAVTGDK-KKEQQPGKmqGTLEDQIIQANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATG 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  257 KLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDAEELMATDNAF 336
Cdd:cd14923   160 KLASADIETYLLEKSRVTFQLSSERSYHIFYQIMSNKKPELIDLLLISTNPFDFPFVSQGEVTVASIDDSEELLATDNAI 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  337 DVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQN 416
Cdd:cd14923   240 DILGFSSEEKVGIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAGYLMGLNSAEMLKGLCCPRVKVGNEYVTKGQN 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  417 VQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVL 496
Cdd:cd14923   320 VQQVTNSVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVL 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  497 EQEEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSANFQKPRNIKGKPEAH 576
Cdd:cd14923   400 EQEEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKPAKGKAEAH 479
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  577 FSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADAPIE--KGKGKAKKGSSFQTVSALHREN 654
Cdd:cd14923   480 FSLVHYAGTVDYNIAGWLDKNKDPLNETVVGLYQKSSLKLLSFLFSNYAGAEAGDSggSKKGGKKKGSSFQTVSAVFREN 559
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  655 LNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQ 734
Cdd:cd14923   560 LNKLMTNLRSTHPHFVRCLIPNETKTPGVMDHYLVMHQLRCNGVLEGIRICRKGFPSRILYADFKQRYRILNASAIPEGQ 639
                         650       660       670
                  ....*....|....*....|....*....|..
gi 124302198  735 FIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd14923   640 FIDSKNASEKLLNSIDVDREQYRFGHTKVFFK 671
MYSc_Myh8 cd14918
class II myosin heavy chain 8, motor domain; Myosin motor domain of perinatal skeletal muscle ...
99-766 0e+00

class II myosin heavy chain 8, motor domain; Myosin motor domain of perinatal skeletal muscle myosin heavy chain 8 (also called MyHC-peri, MyHC-pn). Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. A mutation in this gene results in trismus-pseudocamptodactyly syndrome. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276882 [Multi-domain]  Cd Length: 668  Bit Score: 1151.40  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd14918     1 PGVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  179 ESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQSPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKL 258
Cdd:cd14918    81 ESGAGKTVNTKRVIQYFATIAVTGEKKKEESGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  259 ASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDAEELMATDNAFDV 338
Cdd:cd14918   161 ASADIETYLLEKSRVTFQLKAERSYHIFYQITSNKKPDLIEMLLITTNPYDYAFVSQGEITVPSIDDQEELMATDSAIDI 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  339 LGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQ 418
Cdd:cd14918   241 LGFTPEEKVSIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAAYLQSLNSADLLKALCYPRVKVGNEYVTKGQTVQ 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  419 QVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQ 498
Cdd:cd14918   321 QVYNAVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQ 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  499 EEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSANFQKPRNIKGKPEAHFS 578
Cdd:cd14918   401 EEYKKEGIEWTFIDFGMDLAACIELIEKPLGIFSILEEECMFPKATDTSFKNKLYDQHLGKSANFQKPKVVKGKAEAHFS 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  579 LIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADAPIEKGKGKAKKGSSFQTVSALHRENLNKL 658
Cdd:cd14918   481 LIHYAGTVDYNITGWLDKNKDPLNDTVVGLYQKSAMKTLASLFSTYASAEADSGAKKGAKKKGSSFQTVSALFRENLNKL 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  659 MTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFIDS 738
Cdd:cd14918   561 MTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYGDFKQRYKVLNASAIPEGQFIDS 640
                         650       660
                  ....*....|....*....|....*...
gi 124302198  739 RKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd14918   641 KKASEKLLASIDIDHTQYKFGHTKVFFK 668
MYSc_Myh2_mammals cd14912
class II myosin heavy chain 2, motor domain; Myosin motor domain of type IIa skeletal muscle ...
99-766 0e+00

class II myosin heavy chain 2, motor domain; Myosin motor domain of type IIa skeletal muscle myosin heavy chain 2 (also called MYH2A, MYHSA2, MyHC-IIa, MYHas8, MyHC-2A) in mammals. Mutations in this gene results in inclusion body myopathy-3 and familial congenital myopathy. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276877 [Multi-domain]  Cd Length: 673  Bit Score: 1129.83  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd14912     1 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVTAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  179 ESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQSPGK--GTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATG 256
Cdd:cd14912    81 ESGAGKTVNTKRVIQYFATIAVTGEKKKEEITSGKmqGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  257 KLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDAEELMATDNAF 336
Cdd:cd14912   161 KLASADIETYLLEKSRVTFQLKAERSYHIFYQITSNKKPELIEMLLITTNPYDYPFVSQGEISVASIDDQEELMATDSAI 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  337 DVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQN 416
Cdd:cd14912   241 DILGFTNEEKVSIYKLTGAVMHYGNLKFKQKQREEQAEPDGTEVADKAAYLQSLNSADLLKALCYPRVKVGNEYVTKGQT 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  417 VQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVL 496
Cdd:cd14912   321 VEQVTNAVGALAKAVYEKMFLWMVARINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVL 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  497 EQEEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSANFQKPRNIKGKPEAH 576
Cdd:cd14912   401 EQEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSANFQKPKVVKGKAEAH 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  577 FSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGAD---APIEKGKGKAKKGSSFQTVSALHRE 653
Cdd:cd14912   481 FSLIHYAGVVDYNITGWLDKNKDPLNETVVGLYQKSAMKTLAYLFSGAQTAEgasAGGGAKKGGKKKGSSFQTVSALFRE 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  654 NLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEG 733
Cdd:cd14912   561 NLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPEG 640
                         650       660       670
                  ....*....|....*....|....*....|...
gi 124302198  734 QFIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd14912   641 QFIDSKKASEKLLASIDIDHTQYKFGHTKVFFK 673
MYSc_Myh1_mammals cd14910
class II myosin heavy chain 1, motor domain; Myosin motor domain of type IIx skeletal muscle ...
99-766 0e+00

class II myosin heavy chain 1, motor domain; Myosin motor domain of type IIx skeletal muscle myosin heavy chain 1 (also called MYHSA1, MYHa, MyHC-2X/D, MGC133384) in mammals. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276875 [Multi-domain]  Cd Length: 671  Bit Score: 1127.13  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd14910     1 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVTAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  179 ESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQSPGK--GTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATG 256
Cdd:cd14910    81 ESGAGKTVNTKRVIQYFATIAVTGEKKKEEATSGKmqGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  257 KLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDAEELMATDNAF 336
Cdd:cd14910   161 KLASADIETYLLEKSRVTFQLKAERSYHIFYQIMSNKKPDLIEMLLITTNPYDYAFVSQGEITVPSIDDQEELMATDSAI 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  337 DVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQN 416
Cdd:cd14910   241 EILGFTSDERVSIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAAYLQNLNSADLLKALCYPRVKVGNEYVTKGQT 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  417 VQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVL 496
Cdd:cd14910   321 VQQVYNAVGALAKAVYDKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVL 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  497 EQEEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSANFQKPRNIKGKPEAH 576
Cdd:cd14910   401 EQEEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSNNFQKPKPAKGKVEAH 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  577 FSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADAPI-EKGKGKAKKGSSFQTVSALHRENL 655
Cdd:cd14910   481 FSLIHYAGTVDYNIAGWLDKNKDPLNETVVGLYQKSSMKTLALLFSGAAAAEAEEgGGKKGGKKKGSSFQTVSALFRENL 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  656 NKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQF 735
Cdd:cd14910   561 NKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPEGQF 640
                         650       660       670
                  ....*....|....*....|....*....|.
gi 124302198  736 IDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd14910   641 IDSKKASEKLLGSIDIDHTQYKFGHTKVFFK 671
MYSc_Myh4 cd14915
class II myosin heavy chain 4, motor domain; Myosin motor domain of skeletal muscle myosin ...
99-766 0e+00

class II myosin heavy chain 4, motor domain; Myosin motor domain of skeletal muscle myosin heavy chain 4 (also called MYH2B, MyHC-2B, MyHC-IIb). Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276879 [Multi-domain]  Cd Length: 671  Bit Score: 1126.36  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd14915     1 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVTAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  179 ESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQSPGK--GTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATG 256
Cdd:cd14915    81 ESGAGKTVNTKRVIQYFATIAVTGEKKKEEAASGKmqGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  257 KLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDAEELMATDNAF 336
Cdd:cd14915   161 KLASADIETYLLEKSRVTFQLKAERSYHIFYQIMSNKKPELIEMLLITTNPYDFAFVSQGEITVPSIDDQEELMATDSAV 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  337 DVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQN 416
Cdd:cd14915   241 DILGFSADEKVAIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAAYLTSLNSADLLKALCYPRVKVGNEYVTKGQT 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  417 VQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVL 496
Cdd:cd14915   321 VQQVYNSVGALAKAIYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVL 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  497 EQEEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSANFQKPRNIKGKPEAH 576
Cdd:cd14915   401 EQEEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSNNFQKPKPAKGKAEAH 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  577 FSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADAP-IEKGKGKAKKGSSFQTVSALHRENL 655
Cdd:cd14915   481 FSLVHYAGTVDYNIAGWLDKNKDPLNETVVGLYQKSGMKTLAFLFSGGQTAEAEgGGGKKGGKKKGSSFQTVSALFRENL 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  656 NKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQF 735
Cdd:cd14915   561 NKLMTNLRSTHPHFVRCLIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPEGQF 640
                         650       660       670
                  ....*....|....*....|....*....|.
gi 124302198  736 IDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd14915   641 IDSKKASEKLLGSIDIDHTQYKFGHTKVFFK 671
Myosin_head pfam00063
Myosin head (motor domain);
87-766 0e+00

Myosin head (motor domain);


Pssm-ID: 395017 [Multi-domain]  Cd Length: 674  Bit Score: 1081.92  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198    87 IEDMAMLTFLHEPAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYML 166
Cdd:pfam00063    1 VEDMVELSYLNEPSVLHNLKKRYKSDLIYTYSGLVLVAVNPYKQLPIYSEDMIKAYRGKRRGELPPHIFAIADEAYRSML 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   167 TDRENQSILITGESGAGKTVNTKRVIQYFAVIAAIGDRSKkdqspgKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGK 246
Cdd:pfam00063   81 QDKENQSILISGESGAGKTENTKKIMQYLASVSGSGSAGN------VGRLEEQILQSNPILEAFGNAKTVRNNNSSRFGK 154
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   247 FIRIHFGATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITnNPYDYAFISQ-GETTVASIDD 325
Cdd:pfam00063  155 YIEIQFDAKGDIVGGKIETYLLEKSRVVYQAEGERNYHIFYQLLAGASAQLKKELRLT-NPKDYHYLSQsGCYTIDGIDD 233
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   326 AEELMATDNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVK 405
Cdd:pfam00063  234 SEEFKITDKAMDILGFSDEEQMGIFRIVAAILHLGNIEFKKERNDEQAVPDDTENLQKAASLLGIDSTELEKALCKRRIK 313
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   406 VGNEYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATLETKQ-PRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEK 484
Cdd:pfam00063  314 TGRETVSKPQNVEQANYARDALAKAIYSRLFDWLVDRINKSLDVKTiEKASFIGVLDIYGFEIFEKNSFEQLCINYVNEK 393
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   485 LQQFFNHHMFVLEQEEYKKEGIEWTFIDFGmDLQACIDLIE-KPMGIMSILEEECMFPKATDMTFKAKLFDNHlGKSANF 563
Cdd:pfam00063  394 LQQFFNHHMFKLEQEEYVREGIEWTFIDFG-DNQPCIDLIEkKPLGILSLLDEECLFPKATDQTFLDKLYSTF-SKHPHF 471
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   564 QKPRNIKgkpEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADAPIEKGKGKAK---- 639
Cdd:pfam00063  472 QKPRLQG---ETHFIIKHYAGDVEYNVEGFLEKNKDPLNDDLVSLLKSSSDPLLAELFPDYETAESAAANESGKSTpkrt 548
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   640 KGSSFQTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFR 719
Cdd:pfam00063  549 KKKRFITVGSQFKESLGELMKTLNSTNPHYIRCIKPNEKKRAGVFDNSLVLHQLRCNGVLEGIRIRRAGFPNRITFQEFV 628
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....*..
gi 124302198   720 QRYRILNPAAIPEGqFIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:pfam00063  629 QRYRILAPKTWPKW-KGDAKKGCEAILQSLNLDKEEYQFGKTKIFFR 674
MYSc_Myh15_mammals cd14929
class II myosin heavy chain 15, motor domain; Myosin motor domain of sarcomeric myosin heavy ...
99-766 0e+00

class II myosin heavy chain 15, motor domain; Myosin motor domain of sarcomeric myosin heavy chain 15 in mammals (also called KIAA1000) . MYH15 is a slow-twitch myosin. Myh15 is a ventricular myosin heavy chain. Myh15 is absent in embryonic and fetal muscles and is found in orbital layer of extraocular muscles at birth. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276892 [Multi-domain]  Cd Length: 662  Bit Score: 1076.15  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd14929     1 ASVLHTLRRRYDHWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFTG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  179 ESGAGKTVNTKRVIQYFAVIAAIGDRSKKdqspgKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKL 258
Cdd:cd14929    81 ESGAGKTVNTKHIIQYFATIAAMIESKKK-----LGALEDQIMQANPVLEAFGNAKTLRNDNSSRFGKFIRMHFGARGML 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  259 ASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKpELLDMLLITNNPYDYAFISQGETTVASIDDAEELMATDNAFDV 338
Cdd:cd14929   156 SSADIDIYLLEKSRVIFQQPGERNYHIFYQILSGKK-ELRDLLLVSANPSDFHFCSCGAVAVESLDDAEELLATEQAMDI 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  339 LGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQ 418
Cdd:cd14929   235 LGFLPDEKYGCYKLTGAIMHFGNMKFKQKPREEQLEADGTENADKAAFLMGINSSELVKGLIHPRIKVGNEYVTRSQNIE 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  419 QVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQ 498
Cdd:cd14929   315 QVTYAVGALSKSIYERMFKWLVARINRVLDAKLSRQFFIGILDITGFEILDYNSLEQLCINFTNEKLQQFFNQHMFVLEQ 394
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  499 EEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSANFQKPRNIKGKPEAHFS 578
Cdd:cd14929   395 EEYRKEGIDWVSIDFGLDLQACIDLIEKPMGIFSILEEECMFPKATDLTFKTKLFDNHFGKSVHFQKPKPDKKKFEAHFE 474
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  579 LIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADAPIEKGKGKAKKGSSFQTVSALHRENLNKL 658
Cdd:cd14929   475 LVHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFENYISTDSAIQFGEKKRKKGASFQTVASLHKENLNKL 554
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  659 MTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFIDS 738
Cdd:cd14929   555 MTNLKSTAPHFVRCINPNVNKIPGVLDPYLVLQQLRCNGVLEGIRICREGFPNRLLYADFKQRYCILNPRTFPKSKFVSS 634
                         650       660
                  ....*....|....*....|....*...
gi 124302198  739 RKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd14929   635 RKAAEELLGSLEIDHTQYRFGITKVFFK 662
MYSc smart00242
Myosin. Large ATPases; ATPase; molecular motor. Muscle contraction consists of a cyclical ...
80-778 0e+00

Myosin. Large ATPases; ATPase; molecular motor. Muscle contraction consists of a cyclical interaction between myosin and actin. The core of the myosin structure is similar in fold to that of kinesin.


Pssm-ID: 214580 [Multi-domain]  Cd Length: 677  Bit Score: 1029.41  E-value: 0e+00
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198     80 NPPKFDKIEDMAMLTFLHEPAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISD 159
Cdd:smart00242    1 NPPKFEGVEDLVLLTYLNEPAVLHNLKKRYLKDLIYTYIGLVLVAVNPYKQLPIYTDEVIKKYRGKSRGELPPHVFAIAD 80
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198    160 NAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFAVIAAigdrskkdQSPGKGTLEDQIIQANPALEAFGNAKTVRND 239
Cdd:smart00242   81 NAYRNMLNDKENQSIIISGESGAGKTENTKKIMQYLASVSG--------SNTEVGSVEDQILESNPILEAFGNAKTLRNN 152
                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198    240 NSSRFGKFIRIHFGATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNnPYDYAFISQGET- 318
Cdd:smart00242  153 NSSRFGKFIEIHFDAKGKIIGAKIETYLLEKSRVVSQAKGERNYHIFYQLLAGASEELKKELGLKS-PEDYRYLNQGGCl 231
                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198    319 TVASIDDAEELMATDNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQA-EPDGTEEADKSAYLMGLNSADLLK 397
Cdd:smart00242  232 TVDGIDDAEEFKETLNAMRVLGFSEEEQESIFKILAAILHLGNIEFEEGRNDNAAsTVKDKEELSNAAELLGVDPEELEK 311
                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198    398 GLCHPRVKVGNEYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLC 477
Cdd:smart00242  312 ALTKRKIKTGGEVITKPLNVEQALDARDALAKALYSRLFDWLVKRINQSLSFKDGSTYFIGVLDIYGFEIFEVNSFEQLC 391
                           410       420       430       440       450       460       470       480
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198    478 INFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGmDLQACIDLIE-KPMGIMSILEEECMFPKATDMTFKAKLfDNH 556
Cdd:smart00242  392 INYANEKLQQFFNQHVFKLEQEEYEREGIDWTFIDFF-DNQDCIDLIEkKPPGILSLLDEECRFPKGTDQTFLEKL-NQH 469
                           490       500       510       520       530       540       550       560
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198    557 LGKSANFQKPRNikgKPEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGadapiekgkg 636
Cdd:smart00242  470 HKKHPHFSKPKK---KGRTEFIIKHYAGDVTYDVTGFLEKNKDTLSDDLIELLQSSKNPLIASLFPSGVS---------- 536
                           570       580       590       600       610       620       630       640
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198    637 KAKKGSSFQTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYG 716
Cdd:smart00242  537 NAGSKKRFQTVGSQFKEQLNELMDTLNSTNPHFIRCIKPNEEKKPGDFDSSLVLHQLRYLGVLENIRIRRAGFPYRLPFD 616
                           650       660       670       680       690       700
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 124302198    717 DFRQRYRILNPAAIPEGQFiDSRKGAEKLLSSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRD 778
Cdd:smart00242  617 EFLQRYRVLLPDTWPPWGG-DAKKACEALLQSLGLDEDEYQLGKTKVFLRPGQLAELEELRE 677
MYSc_Myh1_insects_crustaceans cd14909
class II myosin heavy chain 1, motor domain; Myosin motor domain of type IIx skeletal muscle ...
99-766 0e+00

class II myosin heavy chain 1, motor domain; Myosin motor domain of type IIx skeletal muscle myosin heavy chain 1 (also called MYHSA1, MYHa, MyHC-2X/D, MGC133384) in insects and crustaceans. Myh1 is a type I skeletal muscle myosin that in Humans is encoded by the MYH1 gene. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276874  Cd Length: 666  Bit Score: 1016.69  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd14909     1 ASVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  179 ESGAGKTVNTKRVIQYFAVIAAigDRSKKDQSPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKL 258
Cdd:cd14909    81 ESGAGKTENTKKVIAYFATVGA--SKKTDEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  259 ASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDAEELMATDNAFDV 338
Cdd:cd14909   159 AGADIETYLLEKARVISQQSLERSYHIFYQIMSGSVPGVKEMCLLSDNIYDYYIVSQGKVTVPNVDDGEEFSLTDQAFDI 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  339 LGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQ 418
Cdd:cd14909   239 LGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRNVQ 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  419 QVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQ 498
Cdd:cd14909   319 QVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQ 398
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  499 EEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSANFQKPRNIK-GKPEAHF 577
Cdd:cd14909   399 EEYKREGIDWAFIDFGMDLLACIDLIEKPMGILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKpGQQAAHF 478
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  578 SLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADA-PIEKGKGKAKKGSSFQTVSALHRENLN 656
Cdd:cd14909   479 AIAHYAGCVSYNITGWLEKNKDPLNDTVVDQFKKSQNKLLIEIFADHAGQSGgGEQAKGGRGKKGGGFATVSSAYKEQLN 558
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  657 KLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQfi 736
Cdd:cd14909   559 SLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKILNPAGIQGEE-- 636
                         650       660       670
                  ....*....|....*....|....*....|
gi 124302198  737 DSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd14909   637 DPKKAAEIILESIALDPDQYRLGHTKVFFR 666
MYSc_Myh16 cd14934
class II myosin heavy chain 16, motor domain; Myosin motor domain of myosin heavy chain 16 ...
100-766 0e+00

class II myosin heavy chain 16, motor domain; Myosin motor domain of myosin heavy chain 16 pseudogene (also called MHC20, MYH16, and myh5), encoding a sarcomeric myosin heavy chain expressed in nonhuman primate masticatory muscles, is inactivated in humans. This cd contains Myh16 in mammals. MYH16 has intermediate fibres between that of slow type 1 and fast 2B fibres, but exert more force than any other fibre type examined. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. Some of the data used for this classification were produced by the CyMoBase team at the Max-Planck-Institute for Biophysical Chemistry. The sequence names are composed of the species abbreviation followed by the protein abbreviation and optional protein classifier and variant designations.


Pssm-ID: 276896 [Multi-domain]  Cd Length: 659  Bit Score: 1011.10  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  100 AVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGE 179
Cdd:cd14934     2 SVLDNLRQRYTNMRIYTYSGLFCVTVNPYKWLPIYGARVANMYKGKKRTEMPPHLFSISDNAYHDMLMDRENQSMLITGE 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  180 SGAGKTVNTKRVIQYFAVIAAIGdrskKDQSPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLA 259
Cdd:cd14934    82 SGAGKTENTKKVIQYFANIGGTG----KQSSDGKGSLEDQIIQANPVLEAFGNAKTTRNNNSSRFGKFIRIHFGTTGKLA 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  260 SADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDAEELMATDNAFDVL 339
Cdd:cd14934   158 GADIESYLLEKSRVISQQAAERGYHIFYQILSNKKPELIESLLLVPNPKEYHWVSQGVTVVDNMDDGEELQITDVAFDVL 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  340 GFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQQ 419
Cdd:cd14934   238 GFSAEEKIGVYKLTGGIMHFGNMKFKQKPREEQAEVDTTEVADKVAHLMGLNSGELQKGITRPRVKVGNEFVQKGQNMEQ 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  420 VIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQE 499
Cdd:cd14934   318 CNNSIGALGKAVYDKMFKWLVVRINKTLDTKMQRQFFIGVLDIAGFEIFEFNSFEQLCINFTNEKLQQFFNHHMFVLEQE 397
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  500 EYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSANFQKPRNIKGK-PEAHFS 578
Cdd:cd14934   398 EYKREGIEWVFIDFGLDLQACIDLLEKPMGIFSILEEQCVFPKATDATFKAALYDNHLGKSSNFLKPKGGKGKgPEAHFE 477
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  579 LIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADApiekgKGKAKKGSSFQTVSALHRENLNKL 658
Cdd:cd14934   478 LVHYAGTVGYNITGWLEKNKDPLNETVVGLFQKSSLGLLALLFKEEEAPAG-----SKKQKRGSSFMTVSNFYREQLNKL 552
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  659 MTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGqFIDS 738
Cdd:cd14934   553 MTTLHSTAPHFVRCIVPNEFKQSGVVDAHLIMHQLACNGVLEGIRICRKGFPNRLQYPEFKQRYQVLNPNVIPQG-FVDN 631
                         650       660
                  ....*....|....*....|....*...
gi 124302198  739 RKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd14934   632 KKASELLLGSIDLDVNEYKIGHTKVFFR 659
COG5022 COG5022
Myosin heavy chain [General function prediction only];
37-1432 0e+00

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 855.91  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   37 VFVPDDKQEFVKAKIVSRE--GGKVTAE--TEYGKTVTVKEDQVMQ--QNPPKFDKIEDMAMLTFLHEPAVLYNLKDRYG 110
Cdd:COG5022    12 CWIPDEEKGWIWAEIIKEAfnKGKVTEEgkKEDGESVSVKKKVLGNdrIKLPKFDGVDDLTELSYLNEPAVLHNLEKRYN 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  111 SWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKR 190
Cdd:COG5022    92 NGQIYTYSGLVLIAVNPYRDLGIYTDDIIQSYSGKNRLELEPHVFAIAEEAYRNLLSEKENQTIIISGESGAGKTENAKR 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  191 VIQYFAVIAAIgdrskkdQSPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEK 270
Cdd:COG5022   172 IMQYLASVTSS-------STVEISSIEKQILATNPILEAFGNAKTVRNDNSSRFGKYIKIEFDENGEICGAKIETYLLEK 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  271 SRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNnPYDYAFISQGE-TTVASIDDAEELMATDNAFDVLGFTSEEKNSM 349
Cdd:COG5022   245 SRVVHQNKNERNYHIFYQLLAGDPEELKKLLLLQN-PKDYIYLSQGGcDKIDGIDDAKEFKITLDALKTIGIDEEEQDQI 323
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  350 YKLTGAIMHFGNMKFKlKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQQVIYATGALAK 429
Cdd:COG5022   324 FKILAAILHIGNIEFK-EDRNGAAIFSDNSVLDKACYLLGIDPSLFVKWLVKRQIKTGGEWIVVPLNLEQALAIRDSLAK 402
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  430 AVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWT 509
Cdd:COG5022   403 ALYSNLFDWIVDRINKSLDHSAAASNFIGVLDIYGFEIFEKNSFEQLCINYTNEKLQQFFNQHMFKLEQEEYVKEGIEWS 482
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  510 FIDFgMDLQACIDLIEK--PMGIMSILEEECMFPKATDMTFKAKLFDN-HLGKSANFQKPRNIKGKpeahFSLIHYAGIV 586
Cdd:COG5022   483 FIDY-FDNQPCIDLIEKknPLGILSLLDEECVMPHATDESFTSKLAQRlNKNSNPKFKKSRFRDNK----FVVKHYAGDV 557
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  587 DYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADapiekgkgkakKGSSFQTVSALHRENLNKLMTNLRSTH 666
Cdd:COG5022   558 EYDVEGFLDKNKDPLNDDLLELLKASTNEFVSTLFDDEENIE-----------SKGRFPTLGSRFKESLNSLMSTLNSTQ 626
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  667 PHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFI---DSRKGAE 743
Cdd:COG5022   627 PHYIRCIKPNEEKSPWTFDNQMVLSQLRCCGVLETIRISRAGFPSRWTFDEFVQRYRILSPSKSWTGEYTwkeDTKNAVK 706
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  744 KLLSSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITRIQAQSRGVLARMEYKKLLERRDSLLVIQWNIRAFMG 823
Cdd:COG5022   707 SILEELVIDSSKYQIGNTKVFFKAGVLAALEDMRDAKLDNIATRIQRAIRGRYLRRRYLQALKRIKKIQVIQHGFRLRRL 786
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  824 VKNWPWMKLYFKIKPLLKSAEREKEMASMKEEFTRLKEALEK----SEARRKELEEKMVSLLQE---------------K 884
Cdd:COG5022   787 VDYELKWRLFIKLQPLLSLLGSRKEYRSYLACIIKLQKTIKRekklRETEEVEFSLKAEVLIQKfgrslkakkrfsllkK 866
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  885 NDLQLQVQAEQDNL--------ADAEER----------------------CDQLIKNKIQLE--AKVKEMNE--RLEDEE 930
Cdd:COG5022   867 ETIYLQSAQRVELAerqlqelkIDVKSIsslklvnleleseiielkkslsSDLIENLEFKTEliARLKKLLNniDLEEGP 946
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  931 EMNAELTAKKRKLEDECSELKRDIDDLELTLakveKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQ----- 1005
Cdd:COG5022   947 SIEYVKLPELNKLHEVESKLKETSEEYEDLL----KKSTILVREGNKANSELKNFKKELAELSKQYGALQESTKQlkelp 1022
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1006 -ALDDLQAEEDKVNTLTKAKvKLEQQVDDLEGSLEQEKK------VRMDLERAKRKLEGDLKLTQESIMDLEN-----DK 1073
Cdd:COG5022  1023 vEVAELQSASKIISSESTEL-SILKPLQKLKGLLLLENNqlqaryKALKLRRENSLLDDKQLYQLESTENLLKtinvkDL 1101
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1074 QQLDERLKKKDFELNAL------NARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEIS 1147
Cdd:COG5022  1102 EVTNRNLVKPANVLQFIvaqmikLNLLQEISKFLSQLVNTLEPVFQKLSVLQLELDGLFWEANLEALPSPPPFAALSEKR 1181
                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1148 ER----LEEAGGATSVQIEMNK-KREAEFQKMRRDLEEatlqheataaalrkkhADSVAELGEQIDNLQRVKQKLEKEKS 1222
Cdd:COG5022  1182 LYqsalYDEKSKLSSSEVNDLKnELIALFSKIFSGWPR----------------GDKLKKLISEGWVPTEYSTSLKGFNN 1245
                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1223 EFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQ--RAKLQTENGELSRQLDEKEALISQ 1300
Cdd:COG5022  1246 LNKKFDTPASMSNEKLLSLLNSIDNLLSSYKLEEEVLPATINSLLQYINVGLFNalRTKASSLRWKSATEVNYNSEELDD 1325
                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1301 LTRgkltyTQQLEDLKRQLE---EEVKAKNALAHALQSARHDCDLLREQYEEETEA-KAELQRVLSKANSEvAQWRTKYE 1376
Cdd:COG5022  1326 WCR-----EFEISDVDEELEeliQAVKVLQLLKDDLNKLDELLDACYSLNPAEIQNlKSRYDPADKENNLP-KEILKKIE 1399
                        1450      1460      1470      1480      1490
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 124302198 1377 TDAIQRTEELE-EAKKKLAQRLQE-AEEAVEAVNAKCSSLEKTKhRLQNEIEDLMVDV 1432
Cdd:COG5022  1400 ALLIKQELQLSlEGKDETEVHLSEiFSEEKSLISLDRNSIYKEE-VLSSLSALLTKEK 1456
MYSc cd00124
Myosin motor domain superfamily; Myosin motor domain. The catalytic (head) domain has ATPase ...
99-766 0e+00

Myosin motor domain superfamily; Myosin motor domain. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276950 [Multi-domain]  Cd Length: 633  Bit Score: 845.33  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKR-SEAPPHIFSISDNAYQYMLTDRENQSILIT 177
Cdd:cd00124     1 AAILHNLRERYARDLIYTYVGDILVAVNPFKWLPLYSEEVMEKYRGKGRsADLPPHVFAVADAAYRAMLRDGQNQSILIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  178 GESGAGKTVNTKRVIQYFAVIAAigdRSKKDQSPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 257
Cdd:cd00124    81 GESGAGKTETTKLVLKYLAALSG---SGSSKSSSSASSIEQQILQSNPILEAFGNAKTVRNDNSSRFGKFIELQFDPTGR 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  258 LASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLIT---NNPYDYAFISQGE-TTVASIDDAEELMATD 333
Cdd:cd00124   158 LVGASIETYLLEKSRVVSQAPGERNFHIFYQLLAGLSDGAREELKLElllSYYYLNDYLNSSGcDRIDGVDDAEEFQELL 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  334 NAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREE--QAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYV 411
Cdd:cd00124   238 DALDVLGFSDEEQDSIFRILAAILHLGNIEFEEDEEDEdsSAEVADDESLKAAAKLLGVDAEDLEEALTTRTIKVGGETI 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  412 TKGQNVQQVIYATGALAKAVYERMFNWMVTRINATL--ETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFF 489
Cdd:cd00124   318 TKPLTVEQAEDARDALAKALYSRLFDWLVNRINAALspTDAAESTSFIGILDIFGFENFEVNSFEQLCINYANEKLQQFF 397
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  490 NHHMFVLEQEEYKKEGIEWTFIDFgMDLQACIDLIE-KPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSANFQKPRn 568
Cdd:cd00124   398 NQHVFKLEQEEYEEEGIDWSFIDF-PDNQDCLDLIEgKPLGILSLLDEECLFPKGTDATFLEKLYSAHGSHPRFFSKKR- 475
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  569 ikgKPEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSlkllstlfanyagadapiekgkgkakkgssfqtvs 648
Cdd:cd00124   476 ---KAKLEFGIKHYAGDVTYDADGFLEKNKDTLPPDLVDLLRSGS----------------------------------- 517
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  649 aLHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPA 728
Cdd:cd00124   518 -QFRSQLDALMDTLNSTQPHFVRCIKPNDEKKPGLFDPELVLEQLRCAGVLEAVRIRRAGYPVRLPFDEFLKRYRILAPG 596
                         650       660       670
                  ....*....|....*....|....*....|....*...
gi 124302198  729 AiPEGQFIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd00124   597 A-TEKASDSKKAAVLALLLLLKLDSSGYQLGKTKVFLR 633
MYSc_Myh2_insects_mollusks cd14911
class II myosin heavy chain 2, motor domain; Myosin motor domain of type IIa skeletal muscle ...
100-766 0e+00

class II myosin heavy chain 2, motor domain; Myosin motor domain of type IIa skeletal muscle myosin heavy chain 2 (also called MYH2A, MYHSA2, MyHC-IIa, MYHas8, MyHC-2A) in insects and mollusks. This gene encodes a member of the class II or conventional myosin heavy chains, and functions in skeletal muscle contraction. Mutations in this gene results in inclusion body myopathy-3 and familial congenital myopathy. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276876 [Multi-domain]  Cd Length: 674  Bit Score: 806.90  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  100 AVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGE 179
Cdd:cd14911     2 SVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKIMERYKGIKRHEVPPHVFAITDSAYRNMLGDREDQSILCTGE 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  180 SGAGKTVNTKRVIQYFAVIAAigDRSKKDQSPGK---------GTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRI 250
Cdd:cd14911    82 SGAGKTENTKKVIQFLAYVAA--SKPKGSGAVPHpavnpavliGELEQQLLQANPILEAFGNAKTVKNDNSSRFGKFIRI 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  251 HFGATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLItNNPYDYAFISQGETTVASIDDAEELM 330
Cdd:cd14911   160 NFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQREKFIL-DDVKSYAFLSNGSLPVPGVDDYAEFQ 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  331 ATDNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAE-PDGTEeADKSAYLMGLNSADLLKGLCHPRVKVGNE 409
Cdd:cd14911   239 ATVKSMNIMGMTSEDFNSIFRIVSAVLLFGSMKFRQERNNDQATlPDNTV-AQKIAHLLGLSVTDMTRAFLTPRIKVGRD 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  410 YVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATLE-TKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQF 488
Cdd:cd14911   318 FVTKAQTKEQVEFAVEAIAKACYERMFKWLVNRINRSLDrTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNEKLQQL 397
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  489 FNHHMFVLEQEEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLgksanfQKPRN 568
Cdd:cd14911   398 FNHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPGGIMALLDEECWFPKATDKTFVDKLVSAHS------MHPKF 471
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  569 IKG--KPEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANY----AGADAPIEKGKGKAKKGS 642
Cdd:cd14911   472 MKTdfRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQDPFVVNIWKDAeivgMAQQALTDTQFGARTRKG 551
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  643 SFQTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRY 722
Cdd:cd14911   552 MFRTVSHLYKEQLAKLMDTLRNTNPNFVRCIIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRY 631
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....
gi 124302198  723 RILNPAAIPEGqFIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd14911   632 ELLTPNVIPKG-FMDGKKACEKMIQALELDSNLYRVGQSKIFFR 674
MYSc_Myh10 cd14920
class II myosin heavy chain 10, motor domain; Myosin motor domain of non-muscle myosin heavy ...
100-766 0e+00

class II myosin heavy chain 10, motor domain; Myosin motor domain of non-muscle myosin heavy chain 10 (also called NMMHCB). Mutations in this gene have been associated with May-Hegglin anomaly and developmental defects in brain and heart. Multiple transcript variants encoding different isoforms have been found for this gene. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276952 [Multi-domain]  Cd Length: 673  Bit Score: 772.26  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  100 AVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGE 179
Cdd:cd14920     2 SVLHNLKDRYYSGLIYTYSGLFCVVINPYKNLPIYSENIIEMYRGKKRHEMPPHIYAISESAYRCMLQDREDQSILCTGE 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  180 SGAGKTVNTKRVIQYFAVIAAIGDRSKKDQSPGKgtLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLA 259
Cdd:cd14920    82 SGAGKTENTKKVIQYLAHVASSHKGRKDHNIPGE--LERQLLQANPILESFGNAKTVKNDNSSRFGKFIRINFDVTGYIV 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  260 SADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPEL-LDMLLITNNpyDYAFISQGETTVASIDDAEELMATDNAFDV 338
Cdd:cd14920   160 GANIETYLLEKSRAVRQAKDERTFHIFYQLLSGAGEHLkSDLLLEGFN--NYRFLSNGYIPIPGQQDKDNFQETMEAMHI 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  339 LGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAE-PDGTeEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNV 417
Cdd:cd14920   238 MGFSHEEILSMLKVVSSVLQFGNISFKKERNTDQASmPENT-VAQKLCHLLGMNVMEFTRAILTPRIKVGRDYVQKAQTK 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  418 QQVIYATGALAKAVYERMFNWMVTRINATLETKQpRQ--YFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFV 495
Cdd:cd14920   317 EQADFAVEALAKATYERLFRWLVHRINKALDRTK-RQgaSFIGILDIAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFI 395
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  496 LEQEEYKKEGIEWTFIDFGMDLQACIDLIEKPM---GIMSILEEECMFPKATDMTFKAKLFdNHLGKSANFQKPRNIKGk 572
Cdd:cd14920   396 LEQEEYQREGIEWNFIDFGLDLQPCIDLIERPAnppGVLALLDEECWFPKATDKTFVEKLV-QEQGSHSKFQKPRQLKD- 473
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  573 pEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFAN---YAGAD----APIEKGKGKAKKGSS-F 644
Cdd:cd14920   474 -KADFCIIHYAGKVDYKADEWLMKNMDPLNDNVATLLHQSSDRFVAELWKDvdrIVGLDqvtgMTETAFGSAYKTKKGmF 552
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  645 QTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRI 724
Cdd:cd14920   553 RTVGQLYKESLTKLMATLRNTNPNFVRCIIPNHEKRAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEI 632
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|..
gi 124302198  725 LNPAAIPEGqFIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd14920   633 LTPNAIPKG-FMDGKQACERMIRALELDPNLYRIGQSKIFFR 673
MYSc_Myh18 cd14932
class II myosin heavy chain 18, motor domain; Myosin motor domain of muscle myosin heavy chain ...
100-766 0e+00

class II myosin heavy chain 18, motor domain; Myosin motor domain of muscle myosin heavy chain 18. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276895 [Multi-domain]  Cd Length: 676  Bit Score: 721.43  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  100 AVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGE 179
Cdd:cd14932     2 SVLHNLKERYYSGLIYTYSGLFCVVINPYKYLPIYSEEIVNMYKGKKRHEMPPHIYAITDTAYRSMMQDREDQSILCTGE 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  180 SGAGKTVNTKRVIQYFAVIAAiGDRSKKDQSP---GKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATG 256
Cdd:cd14932    82 SGAGKTENTKKVIQYLAYVAS-SFKTKKDQSSialSHGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVNG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  257 KLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPyDYAFISQGETTVASIDDAEELMATDNAF 336
Cdd:cd14932   161 YIVGANIETYLLEKSRAIRQAKDERAFHIFYYLLTGAGDKLRSELCLEDYS-KYRFLSNGNVTIPGQQDKELFAETMEAF 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  337 DVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAE-PDGTeEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQ 415
Cdd:cd14932   240 RIMSIPEEEQTGLLKVVSAVLQLGNMSFKKERNSDQASmPDDT-AAQKVCHLLGMNVTDFTRAILSPRIKVGRDYVQKAQ 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  416 NVQQVIYATGALAKAVYERMFNWMVTRINATLE-TKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMF 494
Cdd:cd14932   319 TQEQAEFAVEALAKASYERMFRWLVMRINKALDkTKRQGASFIGILDIAGFEIFELNSFEQLCINYTNEKLQQLFNHTMF 398
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  495 VLEQEEYKKEGIEWTFIDFGMDLQACIDLIEKPM---GIMSILEEECMFPKATDMTFKAKLFdNHLGKSANFQKPRNIKG 571
Cdd:cd14932   399 ILEQEEYQREGIEWSFIDFGLDLQPCIELIEKPNgppGILALLDEECWFPKATDKSFVEKVV-QEQGNNPKFQKPKKLKD 477
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  572 kpEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANY---AGADA----PIEKGKGKAKKGSSF 644
Cdd:cd14932   478 --DADFCIIHYAGKVDYKANEWLMKNMDPLNENVATLLNQSTDKFVSELWKDVdriVGLDKvagmGESLHGAFKTRKGMF 555
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  645 QTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRI 724
Cdd:cd14932   556 RTVGQLYKEQLMNLMTTLRNTNPNFVRCIIPNHEKKAGKLAHHLVLDQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEI 635
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|..
gi 124302198  725 LNPAAIPEGqFIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd14932   636 LTPNAIPKG-FMDGKQACVLMVKALELDPNLYRIGQSKVFFR 676
MYSc_Myo5 cd01380
class V myosin, motor domain; Myo5, also called heavy chain 12, myoxin, are dimeric myosins ...
99-766 0e+00

class V myosin, motor domain; Myo5, also called heavy chain 12, myoxin, are dimeric myosins that transport a variety of intracellular cargo processively along actin filaments, such as melanosomes, synaptic vesicles, vacuoles, and mRNA. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. It also contains a IQ domain and a globular DIL domain. Myosin V is a class of actin-based motor proteins involved in cytoplasmic vesicle transport and anchorage, spindle-pole alignment and mRNA translocation. The protein encoded by this gene is abundant in melanocytes and nerve cells. Mutations in this gene cause Griscelli syndrome type-1 (GS1), Griscelli syndrome type-3 (GS3) and neuroectodermal melanolysosomal disease, or Elejalde disease. Multiple alternatively spliced transcript variants encoding different isoforms have been reported, but the full-length nature of some variants has not been determined. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. Note that the Dictyostelium myoVs are not contained in this child group. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276831 [Multi-domain]  Cd Length: 629  Bit Score: 698.52  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   99 PAVLYNLKDRYG-SWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILIT 177
Cdd:cd01380     1 PAVLHNLKVRFCqRNAIYTYCGIVLVAINPYEDLPIYGEDIIQAYSGQNMGELDPHIFAIAEEAYRQMARDEKNQSIIVS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  178 GESGAGKTVNTKRVIQYFAVIAaiGDRSKKDQspgkgtLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 257
Cdd:cd01380    81 GESGAGKTVSAKYAMRYFATVG--GSSSGETQ------VEEKVLASNPIMEAFGNAKTTRNDNSSRFGKYIEILFDKNYR 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  258 LASADIETYLLEKSRVIFQLKAERDYHIFYQILSNK-KPELLDMLLITNNpyDYAFISQGE-TTVASIDDAEELMATDNA 335
Cdd:cd01380   153 IIGANMRTYLLEKSRVVFQAEEERNYHIFYQLCAAAsLPELKELHLGSAE--DFFYTNQGGsPVIDGVDDAAEFEETRKA 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  336 FDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQ 415
Cdd:cd01380   231 LTLLGISEEEQMEIFRILAAILHLGNVEIKATRNDSASISPDDEHLQIACELLGIDESQLAKWLCKRKIVTRSEVIVKPL 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  416 NVQQVIYATGALAKAVYERMFNWMVTRINATLETKQP--RQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHM 493
Cdd:cd01380   311 TLQQAIVARDALAKHIYAQLFDWIVDRINKALASPVKekQHSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHV 390
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  494 FVLEQEEYKKEGIEWTFIDFgMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLGK-SANFQKPRNIKGK 572
Cdd:cd01380   391 FKLEQEEYVKEEIEWSFIDF-YDNQPCIDLIEGKLGILDLLDEECRLPKGSDENWAQKLYNQHLKKpNKHFKKPRFSNTA 469
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  573 peahFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLlstlfanyagadapiekgkgkakkgssfQTVSALHR 652
Cdd:cd01380   470 ----FIVKHFADDVEYQVEGFLEKNRDTVSEEHLNVLKASKNRK----------------------------KTVGSQFR 517
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  653 ENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAipE 732
Cdd:cd01380   518 DSLILLMETLNSTTPHYVRCIKPNDEKLPFTFDPKRVVQQLRACGVLETIRISAAGFPSRWTYEEFFSRYRVLLPSK--E 595
                         650       660       670
                  ....*....|....*....|....*....|....
gi 124302198  733 GQFIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd01380   596 WLRDDKKKTCENILENLILDPDKYQFGKTKIFFR 629
MYSc_Myh11 cd14921
class II myosin heavy chain 11, motor domain; Myosin motor domain of smooth muscle myosin ...
100-766 0e+00

class II myosin heavy chain 11, motor domain; Myosin motor domain of smooth muscle myosin heavy chain 11 (also called SMMHC, SMHC). The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. Inversion of the MYH11 locus is one of the most frequent chromosomal aberrations found in acute myeloid leukemia. Alternative splicing generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation. Mutations in MYH11 have been described in individuals with thoracic aortic aneurysms leading to acute aortic dissections with patent ductus arteriosus. MYH11 mutations are also thought to contribute to human colorectal cancer and are also associated with Peutz-Jeghers syndrome. The mutations found in human intestinal neoplasia result in unregulated proteins with constitutive motor activity, similar to the mutant myh11 zebrafish. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276885 [Multi-domain]  Cd Length: 673  Bit Score: 697.54  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  100 AVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGE 179
Cdd:cd14921     2 SVLHNLRERYFSGLIYTYSGLFCVVVNPYKHLPIYSEKIVDMYKGKKRHEMPPHIYAIADTAYRSMLQDREDQSILCTGE 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  180 SGAGKTVNTKRVIQYFAVIAAiGDRSKKDQSPgKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLA 259
Cdd:cd14921    82 SGAGKTENTKKVIQYLAVVAS-SHKGKKDTSI-TGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVTGYIV 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  260 SADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPyDYAFISQGETTVASIDDAEELMATDNAFDVL 339
Cdd:cd14921   160 GANIETYLLEKSRAIRQARDERTFHIFYYLIAGAKEKMRSDLLLEGFN-NYTFLSNGFVPIPAAQDDEMFQETLEAMSIM 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  340 GFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAE-PDGTeEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQ 418
Cdd:cd14921   239 GFSEEEQLSILKVVSSVLQLGNIVFKKERNTDQASmPDNT-AAQKVCHLMGINVTDFTRSILTPRIKVGRDVVQKAQTKE 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  419 QVIYATGALAKAVYERMFNWMVTRINATLE-TKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLE 497
Cdd:cd14921   318 QADFAIEALAKATYERLFRWILTRVNKALDkTHRQGASFLGILDIAGFEIFEVNSFEQLCINYTNEKLQQLFNHTMFILE 397
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  498 QEEYKKEGIEWTFIDFGMDLQACIDLIEKPM---GIMSILEEECMFPKATDMTFKAKLFDNHlGKSANFQKPRNIKGKPE 574
Cdd:cd14921   398 QEEYQREGIEWNFIDFGLDLQPCIELIERPNnppGVLALLDEECWFPKATDKSFVEKLCTEQ-GNHPKFQKPKQLKDKTE 476
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  575 ahFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANY---AGADAPIEKGKGKAKKGSS-----FQT 646
Cdd:cd14921   477 --FSIIHYAGKVDYNASAWLTKNMDPLNDNVTSLLNASSDKFVADLWKDVdriVGLDQMAKMTESSLPSASKtkkgmFRT 554
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  647 VSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILN 726
Cdd:cd14921   555 VGQLYKEQLGKLMTTLRNTTPNFVRCIIPNHEKRSGKLDAFLVLEQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILA 634
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|
gi 124302198  727 PAAIPEGqFIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd14921   635 ANAIPKG-FMDGKQACILMIKALELDPNLYRIGQSKIFFR 673
MYSc_Myh9 cd14919
class II myosin heavy chain 9, motor domain; Myosin motor domain of non-muscle myosin heavy ...
100-766 0e+00

class II myosin heavy chain 9, motor domain; Myosin motor domain of non-muscle myosin heavy chain 9 (also called NMMHCA, NMHC-II-A, MHA, FTNS, EPSTS, and DFNA17). Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. The encoded protein is a myosin IIA heavy chain that contains an IQ domain and a myosin head-like domain which is involved in several important functions, including cytokinesis, cell motility and maintenance of cell shape. Defects in this gene have been associated with non-syndromic sensorineural deafness autosomal dominant type 17, Epstein syndrome, Alport syndrome with macrothrombocytopenia, Sebastian syndrome, Fechtner syndrome and macrothrombocytopenia with progressive sensorineural deafness. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276883 [Multi-domain]  Cd Length: 670  Bit Score: 685.29  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  100 AVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGE 179
Cdd:cd14919     2 SVLHNLKERYYSGLIYTYSGLFCVVINPYKNLPIYSEEIVEMYKGKKRHEMPPHIYAITDTAYRSMMQDREDQSILCTGE 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  180 SGAGKTVNTKRVIQYFAVIAAiGDRSKKDQspgkGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLA 259
Cdd:cd14919    82 SGAGKTENTKKVIQYLAHVAS-SHKSKKDQ----GELERQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVNGYIV 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  260 SADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLItnNPYD-YAFISQGETTVASIDDAEELMATDNAFDV 338
Cdd:cd14919   157 GANIETYLLEKSRAIRQAKEERTFHIFYYLLSGAGEHLKTDLLL--EPYNkYRFLSNGHVTIPGQQDKDMFQETMEAMRI 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  339 LGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAE-PDGTeEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNV 417
Cdd:cd14919   235 MGIPEEEQMGLLRVISGVLQLGNIVFKKERNTDQASmPDNT-AAQKVSHLLGINVTDFTRGILTPRIKVGRDYVQKAQTK 313
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  418 QQVIYATGALAKAVYERMFNWMVTRINATLE-TKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVL 496
Cdd:cd14919   314 EQADFAIEALAKATYERMFRWLVLRINKALDkTKRQGASFIGILDIAGFEIFDLNSFEQLCINYTNEKLQQLFNHTMFIL 393
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  497 EQEEYKKEGIEWTFIDFGMDLQACIDLIEKPM---GIMSILEEECMFPKATDMTFKAKLFDNHlGKSANFQKPRNIKGKp 573
Cdd:cd14919   394 EQEEYQREGIEWNFIDFGLDLQPCIDLIEKPAgppGILALLDEECWFPKATDKSFVEKVVQEQ-GTHPKFQKPKQLKDK- 471
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  574 eAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANY---AGAD-----APIEKGKGKAKKGSSFQ 645
Cdd:cd14919   472 -ADFCIIHYAGKVDYKADEWLMKNMDPLNDNIATLLHQSSDKFVSELWKDVdriIGLDqvagmSETALPGAFKTRKGMFR 550
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  646 TVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRIL 725
Cdd:cd14919   551 TVGQLYKEQLAKLMATLRNTNPNFVRCIIPNHEKKAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRVVFQEFRQRYEIL 630
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|.
gi 124302198  726 NPAAIPEGqFIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd14919   631 TPNSIPKG-FMDGKQACVLMIKALELDSNLYRIGQSKVFFR 670
MYSc_Myh19 cd15896
class II myosin heavy chain19, motor domain; Myosin motor domain of muscle myosin heavy chain ...
100-766 0e+00

class II myosin heavy chain19, motor domain; Myosin motor domain of muscle myosin heavy chain 19. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276899 [Multi-domain]  Cd Length: 675  Bit Score: 680.25  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  100 AVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGE 179
Cdd:cd15896     2 SVLHNLKERYYSGLIYTYSGLFCVVINPYKNLPIYSEEIVEMYKGKKRHEMPPHIYAITDTAYRSMMQDREDQSILCTGE 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  180 SGAGKTVNTKRVIQYFAVIAAiGDRSKKDQSP---GKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATG 256
Cdd:cd15896    82 SGAGKTENTKKVIQYLAHVAS-SHKTKKDQNSlalSHGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVNG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  257 KLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPyDYAFISQGETTVASIDDAEELMATDNAF 336
Cdd:cd15896   161 YIVGANIETYLLEKSRAIRQAKEERTFHIFYYLLTGAGDKLRSELLLENYN-NYRFLSNGNVTIPGQQDKDLFTETMEAF 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  337 DVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQN 416
Cdd:cd15896   240 RIMGIPEDEQIGMLKVVASVLQLGNMSFKKERHTDQASMPDNTAAQKVCHLMGMNVTDFTRAILSPRIKVGRDYVQKAQT 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  417 VQQVIYATGALAKAVYERMFNWMVTRINATLE-TKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFV 495
Cdd:cd15896   320 QEQAEFAVEALAKATYERMFRWLVMRINKALDkTKRQGASFIGILDIAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFI 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  496 LEQEEYKKEGIEWTFIDFGMDLQACIDLIEKPM---GIMSILEEECMFPKATDMTFKAKLFDNHlGKSANFQKPRNIKGk 572
Cdd:cd15896   400 LEQEEYQREGIEWSFIDFGLDLQPCIDLIEKPAsppGILALLDEECWFPKATDKSFVEKVLQEQ-GTHPKFFKPKKLKD- 477
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  573 pEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANY---AGADAPI---EKGKGKAKKGSSFQT 646
Cdd:cd15896   478 -EADFCIIHYAGKVDYKADEWLMKNMDPLNDNVATLLNQSTDKFVSELWKDVdriVGLDKVSgmsEMPGAFKTRKGMFRT 556
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  647 VSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILN 726
Cdd:cd15896   557 VGQLYKEQLSKLMATLRNTNPNFVRCIIPNHEKKAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILT 636
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|
gi 124302198  727 PAAIPEGqFIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd15896   637 PNAIPKG-FMDGKQACVLMIKSLELDPNLYRIGQSKVFFR 675
MYSc_Myh14_mammals cd14930
class II myosin heavy chain 14 motor domain; Myosin motor domain of non-muscle myosin heavy ...
100-766 0e+00

class II myosin heavy chain 14 motor domain; Myosin motor domain of non-muscle myosin heavy chain 14 (also called FLJ13881, KIAA2034, MHC16, MYH17). Its members include mammals, chickens, and turtles. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. Some of the data used for this classification were produced by the CyMoBase team at the Max-Planck-Institute for Biophysical Chemistry. The sequence names are composed of the species abbreviation followed by the protein abbreviation and optional protein classifier and variant designations.


Pssm-ID: 276893 [Multi-domain]  Cd Length: 670  Bit Score: 673.35  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  100 AVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGE 179
Cdd:cd14930     2 SVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPHVYAVTEGAYRSMLQDREDQSILCTGE 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  180 SGAGKTVNTKRVIQYFAVIAAIGDRSKKDQSPGKgtLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLA 259
Cdd:cd14930    82 SGAGKTENTKKVIQYLAHVASSPKGRKEPGVPGE--LERQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVAGYIV 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  260 SADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYdYAFISQGETTVASiDDAEELMATDNAFDVL 339
Cdd:cd14930   160 GANIETYLLEKSRAIRQAKDECSFHIFYQLLGGAGEQLKADLLLEPCSH-YRFLTNGPSSSPG-QERELFQETLESLRVL 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  340 GFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAE-PDGTeEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQ 418
Cdd:cd14930   238 GFSHEEITSMLRMVSAVLQFGNIVLKRERNTDQATmPDNT-AAQKLCRLLGLGVTDFSRALLTPRIKVGRDYVQKAQTKE 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  419 QVIYATGALAKAVYERMFNWMVTRINATLEtKQPRQ--YFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVL 496
Cdd:cd14930   317 QADFALEALAKATYERLFRWLVLRLNRALD-RSPRQgaSFLGILDIAGFEIFQLNSFEQLCINYTNEKLQQLFNHTMFVL 395
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  497 EQEEYKKEGIEWTFIDFGMDLQACIDLIEKPM---GIMSILEEECMFPKATDMTFKAKLFDNHlGKSANFQKPRNIKGkp 573
Cdd:cd14930   396 EQEEYQREGIPWTFLDFGLDLQPCIDLIERPAnppGLLALLDEECWFPKATDKSFVEKVAQEQ-GGHPKFQRPRHLRD-- 472
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  574 EAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAG----------ADAPiekgKGKAKKGSS 643
Cdd:cd14930   473 QADFSVLHYAGKVDYKANEWLMKNMDPLNDNVAALLHQSTDRLTAEIWKDVEGivgleqvsslGDGP----PGGRPRRGM 548
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  644 FQTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYR 723
Cdd:cd14930   549 FRTVGQLYKESLSRLMATLSNTNPSFVRCIVPNHEKRAGKLEPRLVLDQLRCNGVLEGIRICRQGFPNRILFQEFRQRYE 628
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|...
gi 124302198  724 ILNPAAIPEGqFIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd14930   629 ILTPNAIPKG-FMDGKQACEKMIQALELDPNLYRVGQSKIFFR 670
MYSc_Myo1 cd01378
class I myosin, motor domain; Myosin I generates movement at the leading edge in cell motility, ...
100-766 0e+00

class I myosin, motor domain; Myosin I generates movement at the leading edge in cell motility, and class I myosins have been implicated in phagocytosis and vesicle transport. Myosin I, an unconventional myosin, does not form dimers. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. There are 5 myosin subclasses with subclasses c/h, d/g, and a/b have an IQ domain and a TH1 domain. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276829  Cd Length: 652  Bit Score: 663.86  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  100 AVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGE 179
Cdd:cd01378     2 AINENLKKRFENDEIYTYIGHVLISVNPFKDLGIYTDEVLESYRGKNRYEVPPHVFALADSAYRNMKSEKENQCVIISGE 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  180 SGAGKTVNTKRVIQYFAVIAaigdrskKDQSPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLA 259
Cdd:cd01378    82 SGAGKTEASKRIMQYIAAVS-------GGSESEVERVKDMLLASNPLLEAFGNAKTLRNDNSSRFGKYMEIQFDFKGEPV 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  260 SADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDAEELMATDNAFDVL 339
Cdd:cd01378   155 GGHITNYLLEKSRVVGQIKGERNFHIFYQLLKGASQEYLQELGLQRPEQYYYYSKSGCFDVDGIDDAADFKEVLNAMKVI 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  340 GFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDgTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEY---VTKGQN 416
Cdd:cd01378   235 GFTEEEQDSIFRILAAILHLGNIQFAEDEEGNAAISD-TSVLDFVAYLLGVDPDQLEKALTHRTIETGGGGrsvYEVPLN 313
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  417 VQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQ-YFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHhmFV 495
Cdd:cd01378   314 VEQAAYARDALAKAIYSRLFDWIVERINKSLAAKSGGKkKVIGVLDIYGFEIFEKNSFEQFCINYVNEKLQQIFIE--LT 391
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  496 L--EQEEYKKEGIEWTFIDFgMDLQACIDLIE-KPMGIMSILEEECMFP-KATDMTFKAKLfDNHLGKSANFQKPRNIKG 571
Cdd:cd01378   392 LkaEQEEYVREGIEWTPIKY-FNNKIICDLIEeKPPGIFAILDDACLTAgDATDQTFLQKL-NQLFSNHPHFECPSGHFE 469
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  572 KPEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADA---PIekgkgkakkgssfqTVS 648
Cdd:cd01378   470 LRRGEFRIKHYAGDVTYNVEGFLDKNKDLLFKDLKELMQSSSNPFLRSLFPEGVDLDSkkrPP--------------TAG 535
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  649 ALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPA 728
Cdd:cd01378   536 TKFKNSANALVETLMKKQPSYIRCIKPNDNKSPGEFDEELVLHQVKYLGLLENVRVRRAGFAYRQTYEKFLERYKLLSPK 615
                         650       660       670
                  ....*....|....*....|....*....|....*...
gi 124302198  729 AIPEGQFIDsRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd01378   616 TWPAWDGTW-QGGVESILKDLNIPPEEYQMGKTKIFIR 652
MYSc_Myo8 cd01383
class VIII myosin, motor domain; These plant-specific type VIII myosins has been associated ...
99-766 0e+00

class VIII myosin, motor domain; These plant-specific type VIII myosins has been associated with endocytosis, cytokinesis, cell-to-cell coupling and gating at plasmodesmata. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. It also contains IQ domains Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276834  Cd Length: 647  Bit Score: 650.15  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRgkKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd01383     1 PSVLHNLEYRYSQDIIYTKAGPVLIAVNPFKDVPLYGNEFITAYR--QKLLDSPHVYAVADTAYREMMRDEINQSIIISG 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  179 ESGAGKTVNTKRVIQYfavIAAIGDrskkdqspGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKL 258
Cdd:cd01383    79 ESGAGKTETAKIAMQY---LAALGG--------GSSGIENEILQTNPILEAFGNAKTLRNDNSSRFGKLIDIHFDAAGKI 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  259 ASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNnPYDYAFISQGET-TVASIDDAEELMATDNAFD 337
Cdd:cd01383   148 CGAKIQTYLLEKSRVVQLANGERSYHIFYQLCAGASPALREKLNLKS-ASEYKYLNQSNClTIDGVDDAKKFHELKEALD 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  338 VLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNV 417
Cdd:cd01383   227 TVGISKEDQEHIFQMLAAVLWLGNISFQVIDNENHVEVVADEAVSTAASLLGCNANDLMLALSTRKIQAGGDKIVKKLTL 306
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  418 QQVIYATGALAKAVYERMFNWMVTRINATLET-KQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVL 496
Cdd:cd01383   307 QQAIDARDALAKAIYASLFDWLVEQINKSLEVgKRRTGRSISILDIYGFESFQKNSFEQLCINYANERLQQHFNRHLFKL 386
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  497 EQEEYKKEGIEWTFIDFgMDLQACIDLIE-KPMGIMSILEEECMFPKATDMTFKAKLfDNHLGKSANFqkprniKGKPEA 575
Cdd:cd01383   387 EQEEYELDGIDWTKVDF-EDNQECLDLIEkKPLGLISLLDEESNFPKATDLTFANKL-KQHLKSNSCF------KGERGG 458
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  576 HFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADAPIEKGKGKAKKGSSFQTVSALHRENL 655
Cdd:cd01383   459 AFTIRHYAGEVTYDTSGFLEKNRDLLHSDLIQLLSSCSCQLPQLFASKMLDASRKALPLTKASGSDSQKQSVATKFKGQL 538
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  656 NKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQF 735
Cdd:cd01383   539 FKLMQRLENTTPHFIRCIKPNNKQLPGVFDQDLVLQQLRCCGVLEVVRISRSGYPTRMTHQEFARRYGFLLPEDVSASQD 618
                         650       660       670
                  ....*....|....*....|....*....|.
gi 124302198  736 IDSRKGAekLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd01383   619 PLSTSVA--ILQQFNILPEMYQVGYTKLFFR 647
MYSc_Myo7 cd01381
class VII myosin, motor domain; These monomeric myosins have been associated with functions in ...
100-766 0e+00

class VII myosin, motor domain; These monomeric myosins have been associated with functions in sensory systems such as vision and hearing. Mammalian myosin VII has a tail with 2 MyTH4 domains, 2 FERM domains, and a SH3 domain. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276832  Cd Length: 648  Bit Score: 639.69  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  100 AVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGE 179
Cdd:cd01381     2 GILRNLLIRYREKLIYTYTGSILVAVNPYQILPIYTAEQIRLYRNKKIGELPPHIFAIADNAYTNMKRNKRDQCVVISGE 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  180 SGAGKTVNTKRVIQYFAVIaaigdrskkdqSPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLA 259
Cdd:cd01381    82 SGAGKTESTKLILQYLAAI-----------SGQHSWIEQQILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFNKNGVIE 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  260 SADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITnNPYDYAFISQGETTVAS-IDDAEELMATDNAFDV 338
Cdd:cd01381   151 GAKIEQYLLEKSRIVSQAPDERNYHIFYCMLAGLSAEEKKKLELG-DASDYYYLTQGNCLTCEgRDDAAEFADIRSAMKV 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  339 LGFTSEEKNSMYKLTGAIMHFGNMKFKLKQRE--EQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQN 416
Cdd:cd01381   230 LMFTDEEIWDIFKLLAAILHLGNIKFEATVVDnlDASEVRDPPNLERAAKLLEVPKQDLVDALTTRTIFTRGETVVSPLS 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  417 VQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYF---IGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHM 493
Cdd:cd01381   310 AEQALDVRDAFVKGIYGRLFIWIVNKINSAIYKPRGTDSSrtsIGVLDIFGFENFEVNSFEQLCINFANENLQQFFVRHI 389
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  494 FVLEQEEYKKEGIEWTFIDFgMDLQACIDLI-EKPMGIMSILEEECMFPKATDMTFKAKLFDNHlGKSANFQKPRNikgK 572
Cdd:cd01381   390 FKLEQEEYDKEGINWQHIEF-VDNQDVLDLIaLKPMNIMSLIDEESKFPKGTDQTMLEKLHSTH-GNNKNYLKPKS---D 464
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  573 PEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADApiekgkgkaKKGSSFQTVSALHR 652
Cdd:cd01381   465 LNTSFGINHFAGVVFYDTRGFLEKNRDTFSADLLQLVQSSKNKFLKQLFNEDISMGS---------ETRKKSPTLSSQFR 535
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  653 ENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPaAIPE 732
Cdd:cd01381   536 KSLDQLMKTLSACQPFFVRCIKPNEYKKPMLFDRELCVRQLRYSGMMETIRIRKAGYPIRHTFEEFVERYRVLVP-GIPP 614
                         650       660       670
                  ....*....|....*....|....*....|....
gi 124302198  733 GQFIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd01381   615 AHKTDCRAATRKICCAVLGGDADYQLGKTKIFLK 648
MYSc_Myo22 cd14883
class XXII myosin, motor domain; These myosins possess an extended neck with multiple IQ ...
100-766 0e+00

class XXII myosin, motor domain; These myosins possess an extended neck with multiple IQ motifs such as found in class V, VIII, XI, and XIII myosins. These myosins are defined by two tandem MyTH4 and FERM domains. The apicomplexan, but not diatom myosins contain 4-6 WD40 repeats near the end of the C-terminal tail which suggests a possible function of these myosins in signal transduction and transcriptional regulation. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276849 [Multi-domain]  Cd Length: 661  Bit Score: 619.34  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  100 AVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGE 179
Cdd:cd14883     2 GINTNLKVRYKKDLIYTYTGSILVAVNPYKELPIYTQDIVKQYFGKRMGALPPHIFALAEAAYTNMQEDGKNQSVIISGE 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  180 SGAGKTVNTKRVIQYfavIAAIGDRSKKdqspgkgtLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLA 259
Cdd:cd14883    82 SGAGKTETTKLILQY---LCAVTNNHSW--------VEQQILEANTILEAFGNAKTVRNDNSSRFGKFIEVCFDASGHIK 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  260 SADIETYLLEKSRVIFQLKAERDYHIFYQILSNKK--PELLDmLLITNNPYDYAFISQ-GETTVASIDDAEELMATDNAF 336
Cdd:cd14883   151 GAIIQDYLLEQSRITFQAPGERNYHVFYQLLAGAKhsKELKE-KLKLGEPEDYHYLNQsGCIRIDNINDKKDFDHLRLAM 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  337 DVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAE-PDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQ 415
Cdd:cd14883   230 NVLGIPEEMQEGIFSVLSAILHLGNLTFEDIDGETGALtVEDKEILKIVAKLLGVDPDKLKKALTIRQINVRGNVTEIPL 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  416 NVQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFV 495
Cdd:cd14883   310 KVQEARDNRDAMAKALYSRTFAWLVNHINSCTNPGQKNSRFIGVLDIFGFENFKVNSFEQLCINYTNEKLHKFFNHYVFK 389
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  496 LEQEEYKKEGIEWTFIDFgMDLQACIDLIEK-PMGIMSILEEECMFPKATDMTFKAKLFDNHlGKSANFQKPRNIKGKPE 574
Cdd:cd14883   390 LEQEEYEKEGINWSHIVF-TDNQECLDLIEKpPLGILKLLDEECRFPKGTDLTYLEKLHAAH-EKHPYYEKPDRRRWKTE 467
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  575 ahFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLF-----ANYAGADAPIEKGKGKAKKGSSFQTVSA 649
Cdd:cd14883   468 --FGVKHYAGEVTYTVQGFLDKNKDTQQDDLFDLMSRSKNKFVKELFtypdlLALTGLSISLGGDTTSRGTSKGKPTVGD 545
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  650 LHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAA 729
Cdd:cd14883   546 TFKHQLQSLVDVLSATQPWYVRCIKPNSLKEPNVFDDELVLAQLRYAGMLEIIRIRKEGFPIHLTFKEFVDRYLCLDPRA 625
                         650       660       670
                  ....*....|....*....|....*....|....*...
gi 124302198  730 IPEGQfiDSRKGAEK-LLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd14883   626 RSADH--KETCGAVRaLMGLGGLPEDEWQVGKTKVFLR 661
MYSc_Myo11 cd01384
class XI myosin, motor domain; These plant-specific type XI myosin are involved in organelle ...
99-766 0e+00

class XI myosin, motor domain; These plant-specific type XI myosin are involved in organelle transport. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle.


Pssm-ID: 276835  Cd Length: 647  Bit Score: 585.41  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLP-VYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILIT 177
Cdd:cd01384     1 PGVLHNLKVRYELDEIYTYTGNILIAVNPFKRLPhLYDAHMMEQYKGAPLGELSPHVFAVADAAYRAMINEGKSQSILVS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  178 GESGAGKTVNTKRVIQYFAviaaigDRSKKDQSPGKgTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 257
Cdd:cd01384    81 GESGAGKTETTKMLMQYLA------YMGGRAVTEGR-SVEQQVLESNPLLEAFGNAKTVRNNNSSRFGKFVEIQFDDAGR 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  258 LASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLItNNPYDYAFISQGET-TVASIDDAEELMATDNAF 336
Cdd:cd01384   154 ISGAAIRTYLLERSRVVQVSDPERNYHCFYQLCAGAPPEDREKYKL-KDPKQFHYLNQSKCfELDGVDDAEEYRATRRAM 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  337 DVLGFTSEEKNSMYKLTGAIMHFGNMKFKlKQREEQAEPDGTEEADKS----AYLMGLNSADLLKGLCHPRVKVGNEYVT 412
Cdd:cd01384   233 DVVGISEEEQDAIFRVVAAILHLGNIEFS-KGEEDDSSVPKDEKSEFHlkaaAELLMCDEKALEDALCKRVIVTPDGIIT 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  413 KGQNVQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHH 492
Cdd:cd01384   312 KPLDPDAATLSRDALAKTIYSRLFDWLVDKINRSIGQDPNSKRLIGVLDIYGFESFKTNSFEQFCINLANEKLQQHFNQH 391
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  493 MFVLEQEEYKKEGIEWTFIDFgMDLQACIDLIE-KPMGIMSILEEECMFPKATDMTFKAKLFDNhLGKSANFQKPRnikg 571
Cdd:cd01384   392 VFKMEQEEYTKEEIDWSYIEF-VDNQDVLDLIEkKPGGIIALLDEACMFPRSTHETFAQKLYQT-LKDHKRFSKPK---- 465
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  572 KPEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFAnyagadapiEKGKGKAKKGSSFQTVSALH 651
Cdd:cd01384   466 LSRTDFTIDHYAGDVTYQTDLFLDKNKDYVVAEHQALLNASKCPFVAGLFP---------PLPREGTSSSSKFSSIGSRF 536
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  652 RENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIp 731
Cdd:cd01384   537 KQQLQELMETLNTTEPHYIRCIKPNNLLKPGIFENANVLQQLRCGGVLEAVRISCAGYPTRKPFEEFLDRFGLLAPEVL- 615
                         650       660       670
                  ....*....|....*....|....*....|....*
gi 124302198  732 eGQFIDSRKGAEKLLSSLDIdhNQYKFGHTKVFFK 766
Cdd:cd01384   616 -KGSDDEKAACKKILEKAGL--KGYQIGKTKVFLR 647
MYSc_Myo4 cd14872
class IV myosin, motor domain; These myosins all possess a WW domain either N-terminal or ...
99-766 1.75e-174

class IV myosin, motor domain; These myosins all possess a WW domain either N-terminal or C-terminal to their motor domain and a tail with a MyTH4 domain followed by a SH3 domain in some instances. The monomeric Acanthamoebas were the first identified members of this group and have been joined by Stramenopiles. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276839  Cd Length: 644  Bit Score: 545.14  E-value: 1.75e-174
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd14872     1 AMIVHNLRKRFKNDQIYTNVGTILISVNPFKRLPLYTPTVMDQYMHKGPKEMPPHTYNIADDAYRAMIVDAMNQSILISG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  179 ESGAGKTVNTKRVIQYFAVIAAigdrskkdqspGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKL 258
Cdd:cd14872    81 ESGAGKTEATKQCLSFFAEVAG-----------STNGVEQRVLLANPILEAFGNAKTLRNNNSSRFGKWVEIHFDNRGRI 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  259 ASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLlitNNPYDYAFISQGET-TVASIDDAEELMATDNAFD 337
Cdd:cd14872   150 CGASTENYLLEKSRVVYQIKGERNFHIFYQLLASPDPASRGGW---GSSAAYGYLSLSGCiEVEGVDDVADFEEVVLAME 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  338 VLGFTSEEKNSMYKLTGAIMHFGNMKF------KLKQREEQAEPDGTEEAdksAYLMGLNSADLLKGLCHPRVKVgneyv 411
Cdd:cd14872   227 QLGFDDADINNVMSLIAAILKLGNIEFasgggkSLVSGSTVANRDVLKEV---ATLLGVDAATLEEALTSRLMEI----- 298
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  412 tKGQNV-------QQVIYATGALAKAVYERMFNWMVTRINATLE-TKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNE 483
Cdd:cd14872   299 -KGCDPtripltpAQATDACDALAKAAYSRLFDWLVKKINESMRpQKGAKTTFIGVLDIFGFEIFEKNSFEQLCINFTNE 377
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  484 KLQQFFNHHMFVLEQEEYKKEGIEWTFIDFgMDLQACIDLIEK-PMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSan 562
Cdd:cd14872   378 KLQQHFNQYTFKLEEALYQSEGVKFEHIDF-IDNQPVLDLIEKkQPGLMLALDDQVKIPKGSDATFMIAANQTHAAKS-- 454
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  563 FQKPRNIKGKPEaHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFanyagadAPIEkgkgkAKKGS 642
Cdd:cd14872   455 TFVYAEVRTSRT-EFIVKHYAGDVTYDITGFLEKNKDTLQKDLYVLLSSSKNKLIAVLF-------PPSE-----GDQKT 521
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  643 SFQTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRY 722
Cdd:cd14872   522 SKVTLGGQFRKQLSALMTALNATEPHYIRCVKPNQEKRARLFDGFMSLEQLRYAGVFEAVKIRKTGYPFRYSHERFLKRY 601
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....
gi 124302198  723 RILnPAAIPEGQFIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd14872   602 RFL-VKTIAKRVGPDDRQRCDLLLKSLKQDFSKVQVGKTRVLYR 644
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
845-1923 3.34e-173

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 557.10  E-value: 3.34e-173
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   845 REKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNE 924
Cdd:pfam01576    3 QEEEMQAKEEELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQLQAETELCAEAEEMRARLAARKQELEEILHELES 82
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   925 RLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQ 1004
Cdd:pfam01576   83 RLEEEEERSQQLQNEKKKMQQHIQDLEEQLDEEEAARQKLQLEKVTTEAKIKKLEEDILLLEDQNSKLSKERKLLEERIS 162
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1005 QALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKD 1084
Cdd:pfam01576  163 EFTSNLAEEEEKAKSLSKLKNKHEAMISDLEERLKKEEKGRQELEKAKRKLEGESTDLQEQIAELQAQIAELRAQLAKKE 242
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1085 FELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMN 1164
Cdd:pfam01576  243 EELQAALARLEEETAQKNNALKKIRELEAQISELQEDLESERAARNKAEKQRRDLGEELEALKTELEDTLDTTAAQQELR 322
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1165 KKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKAN 1244
Cdd:pfam01576  323 SKREQEVTELKKALEEETRSHEAQLQEMRQKHTQALEELTEQLEQAKRNKANLEKAKQALESENAELQAELRTLQQAKQD 402
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1245 LEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVK 1324
Cdd:pfam01576  403 SEHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKNIKLSKDVSSLESQLQDTQELLQEETR 482
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1325 AKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAiQRTEELEEAKKKLAQRLQEAEEAV 1404
Cdd:pfam01576  483 QKLNLSTRLRQLEDERNSLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKKLEEDA-GTLEALEEGKKRLQRELEALTQQL 561
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1405 EAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKL 1484
Cdd:pfam01576  562 EEKAAAYDKLEKTKNRLQQELDDLLVDLDHQRQLVSNLEKKQKKFDQMLAEEKAISARYAEERDRAEAEAREKETRALSL 641
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1485 KNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLE 1564
Cdd:pfam01576  642 ARALEEALEAKEELERTNKQLRAEMEDLVSSKDDVGKNVHELERSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVN 721
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1565 FNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVK 1644
Cdd:pfam01576  722 MQALKAQFERDLQARDEQGEEKRRQLVKQVRELEAELEDERKQRAQAVAAKKKLELDLKELEAQIDAANKGREEAVKQLK 801
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1645 SLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLI 1724
Cdd:pfam01576  802 KLQAQMKDLQRELEEARASRDEILAQSKESEKKLKNLEAELLQLQEDLAASERARRQAQQERDELADEIASGASGKSALQ 881
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1725 NQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIA 1804
Cdd:pfam01576  882 DEKRRLEARIAQLEEELEEEQSNTELLNDRLRKSTLQVEQLTTELAAERSTSQKSESARQQLERQNKELKAKLQEMEGTV 961
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1805 LKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEE 1884
Cdd:pfam01576  962 KSKFKSSIAALEAKIAQLEEQLEQESRERQAANKLVRRTEKKLKEVLLQVEDERRHADQYKDQAEKGNSRMKQLKRQLEE 1041
                         1050      1060      1070
                   ....*....|....*....|....*....|....*....
gi 124302198  1885 AEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAK 1923
Cdd:pfam01576 1042 AEEEASRANAARRKLQRELDDATESNESMNREVSTLKSK 1080
MYSc_Myo42 cd14903
class XLII myosin, motor domain; The class XLII myosins are comprised of Stramenopiles. Not ...
99-766 2.91e-172

class XLII myosin, motor domain; The class XLII myosins are comprised of Stramenopiles. Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276868 [Multi-domain]  Cd Length: 658  Bit Score: 539.75  E-value: 2.91e-172
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLP-VYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILIT 177
Cdd:cd14903     1 AAILYNVKKRFLRKLPYTYTGDICIAVNPYQWLPeLYTEEQHSKYLNKPKEELPPHVYATSVAAYNHMKRSGRNQSILVS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  178 GESGAGKTVNTKRVIQYFAVIAaigdrskkdqspgkGTLED----QIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFG 253
Cdd:cd14903    81 GESGAGKTETTKILMNHLATIA--------------GGLNDstikKIIEVNPLLESFGNAKTVRNDNSSRFGKFTQLQFD 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  254 ATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDmLLITNNPYDYafisQGETTVASID---DAEELM 330
Cdd:cd14903   147 KNGTLVGAKCRTYLLEKTRVISHERPERNYHIFYQLLASPDVEERL-FLDSANECAY----TGANKTIKIEgmsDRKHFA 221
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  331 ATDNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAE--PDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGN 408
Cdd:cd14903   222 RTKEALSLIGVSEEKQEVLFEVLAGILHLGQLQIQSKPNDDEKSaiAPGDQGAVYATKLLGLSPEALEKALCSRTMRAAG 301
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  409 EYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQF 488
Cdd:cd14903   302 DVYTVPLKKDQAEDCRDALAKAIYSNVFDWLVATINASLGNDAKMANHIGVLDIFGFEHFKHNSFEQFCINYANEKLQQK 381
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  489 FNHHMFVLEQEEYKKEGIEWTFIDFgMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSANFQKPRN 568
Cdd:cd14903   382 FTQDVFKTVQIEYEEEGIRWAHIDF-ADNQDVLAVIEDRLGIISLLNDEVMRPKGNEESFVSKLSSIHKDEQDVIEFPRT 460
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  569 IKgkpeAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADAPIEKGKGKAKKGS-----S 643
Cdd:cd14903   461 SR----TQFTIKHYAGPVTYESLGFLEKHKDALLPDLSDLMRGSSKPFLRMLFKEKVESPAAASTSLARGARRRrggalT 536
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  644 FQTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYR 723
Cdd:cd14903   537 TTTVGTQFKDSLNELMTTIRSTNVHYVRCIKPNSIKSPTELDHLMVVSQLRCAGVIEAIRISRAAYPNRLLHEEFLDKFW 616
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....
gi 124302198  724 ILNPAAipEGQFIDSRKGAEKLLSSLDIDH-NQYKFGHTKVFFK 766
Cdd:cd14903   617 LFLPEG--RNTDVPVAERCEALMKKLKLESpEQYQMGLTRIYFQ 658
MYSc_Myo6 cd01382
class VI myosin, motor domain; Myosin VI is a monomeric myosin, which moves towards the ...
102-766 8.43e-170

class VI myosin, motor domain; Myosin VI is a monomeric myosin, which moves towards the minus-end of actin filaments, in contrast to most other myosins which moves towards the plus-end of actin filaments. It is thought that myosin VI, unlike plus-end directed myosins, does not use a pure lever arm mechanism, but instead steps with a mechanism analogous to the kinesin neck-linker uncoupling model. It has been implicated in a myriad of functions including: the transport of cytoplasmic organelles, maintenance of normal Golgi morphology, endocytosis, secretion, cell migration, border cell migration during development, and in cancer metastasis playing roles in deafness and retinal development among others. While how this is accomplished is largely unknown there are several interacting proteins that have been identified such as disabled homolog 2 (DAB2), GIPC1, synapse-associated protein 97 (SAP97; also known as DLG1) and optineurin, which have been found to target myosin VI to different cellular compartments. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the minus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276833  Cd Length: 649  Bit Score: 532.59  E-value: 8.43e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  102 LYNLKDRYGSWMIYTYSGLFCVTVNPYKWLP-VYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGES 180
Cdd:cd01382     4 LNNIRVRYSKDKIYTYVANILIAVNPYFDIPkLYSSETIKSYQGKSLGTLPPHVFAIADKAYRDMKVLKQSQSIIVSGES 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  181 GAGKTVNTKRVIQYFAVIAAIGDrskkdqspgkGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLAS 260
Cdd:cd01382    84 GAGKTESTKYILRYLTESWGSGA----------GPIEQRILEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVG 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  261 ADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLitnnpydyafisqgetTVASIDDAEELMATDNAFDVLG 340
Cdd:cd01382   154 GFVSHYLLEKSRICVQSKEERNYHIFYRLCAGAPEDLREKLL----------------KDPLLDDVGDFIRMDKAMKKIG 217
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  341 FTSEEKNSMYKLTGAIMHFGNMKFklkqrEEQAEPDG-----TEEADKS----AYLMGLNSADLLKGLCHpRVKVGNEYV 411
Cdd:cd01382   218 LSDEEKLDIFRVVAAVLHLGNIEF-----EENGSDSGggcnvKPKSEQSleyaAELLGLDQDELRVSLTT-RVMQTTRGG 291
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  412 TKGQ------NVQQVIYATGALAKAVYERMFNWMVTRINATLETKQpRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKL 485
Cdd:cd01382   292 AKGTvikvplKVEEANNARDALAKAIYSKLFDHIVNRINQCIPFET-SSYFIGVLDIAGFEYFEVNSFEQFCINYCNEKL 370
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  486 QQFFNHHMFVLEQEEYKKEGIEWTFIDFgMDLQACIDLIE-KPMGIMSILEEECMFPKATDMTFKAKLFDNHLgKSANFQ 564
Cdd:cd01382   371 QQFFNERILKEEQELYEKEGLGVKEVEY-VDNQDCIDLIEaKLVGILDLLDEESKLPKPSDQHFTSAVHQKHK-NHFRLS 448
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  565 KPRniKGKPEAH--------FSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADApiekGKG 636
Cdd:cd01382   449 IPR--KSKLKIHrnlrddegFLIRHFAGAVCYETAQFIEKNNDALHASLESLICESKDKFIRSLFESSTNNNK----DSK 522
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  637 KAKKGSSFQTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYG 716
Cdd:cd01382   523 QKAGKLSFISVGNKFKTQLNLLMDKLRSTGTSFIRCIKPNLKMTSHHFEGAQILSQLQCSGMVSVLDLMQGGFPSRTSFH 602
                         650       660       670       680       690
                  ....*....|....*....|....*....|....*....|....*....|
gi 124302198  717 DFRQRYRILNPAAIPEgqfIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd01382   603 DLYNMYKKYLPPKLAR---LDPRLFCKALFKALGLNENDFKFGLTKVFFR 649
MYSc_Myo15 cd01387
class XV mammal-like myosin, motor domain; The class XV myosins are monomeric. In vertebrates, ...
100-766 3.52e-168

class XV mammal-like myosin, motor domain; The class XV myosins are monomeric. In vertebrates, myosin XV appears to be expressed in sensory tissue and play a role in hearing. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. C-terminal to the head domain are 2 MyTH4 domain, a FERM domain, and a SH3 domain. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276838 [Multi-domain]  Cd Length: 657  Bit Score: 528.55  E-value: 3.52e-168
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  100 AVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGE 179
Cdd:cd01387     2 TVLWNLKTRYERNLIYTYIGSILVSVNPYKMFDIYGLEQVQQYSGRALGELPPHLFAIANLAFAKMLDAKQNQCVVISGE 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  180 SGAGKTVNTKRVIQYFAVIAaigdrskkdQSPGKGTLEdQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFgATGKLA 259
Cdd:cd01387    82 SGSGKTEATKLIMQYLAAVN---------QRRNNLVTE-QILEATPLLEAFGNAKTVRNDNSSRFGKYLEVFF-EGGVIV 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  260 SADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDM--LLitnNPYDYAFISQGETT-VASIDDAEELMATDNAF 336
Cdd:cd01387   151 GAITSQYLLEKSRIVTQAKNERNYHVFYELLAGLPAQLRQKygLQ---EAEKYFYLNQGGNCeIAGKSDADDFRRLLAAM 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  337 DVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQRE---EQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTK 413
Cdd:cd01387   228 QVLGFSSEEQDSIFRILASVLHLGNVYFHKRQLRhgqEGVSVGSDAEIQWVAHLLQISPEGLQKALTFKVTETRRERIFT 307
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  414 GQNVQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHM 493
Cdd:cd01387   308 PLTIDQALDARDAIAKALYALLFSWLVTRVNAIVYSGTQDTLSIAILDIFGFEDLSENSFEQLCINYANENLQYYFNKHV 387
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  494 FVLEQEEYKKEGIEWTFIDFgMDLQACIDLI-EKPMGIMSILEEECMFPKATDMTFKAKLFDNHlGKSANFQKPRniKGK 572
Cdd:cd01387   388 FKLEQEEYIREQIDWTEIAF-ADNQPVINLIsKKPVGILHILDDECNFPQATDHSFLEKCHYHH-ALNELYSKPR--MPL 463
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  573 PEahFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYagadAPIEKGKGKAKKGSSF-------Q 645
Cdd:cd01387   464 PE--FTIKHYAGQVWYQVHGFLDKNRDQLRQDVLELLVSSRTRVVAHLFSSH----RAQTDKAPPRLGKGRFvtmkprtP 537
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  646 TVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRIL 725
Cdd:cd01387   538 TVAARFQDSLLQLLEKMERCNPWFVRCLKPNHKKEPMLFDMDVVMAQLRYSGMLETIRIRKEGYPVRLPFQVFIDRYRCL 617
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|...
gi 124302198  726 NPAAIPEGQFIDSRkgaEKLLSSLD--IDHNQYKFGHTKVFFK 766
Cdd:cd01387   618 VALKLPRPAPGDMC---VSLLSRLCtvTPKDMYRLGATKVFLR 657
MYSc_Myo29 cd14890
class XXIX myosin, motor domain; Class XXIX myosins are comprised of Stramenopiles and have ...
100-766 5.08e-167

class XXIX myosin, motor domain; Class XXIX myosins are comprised of Stramenopiles and have very long tail domains consisting of three IQ motifs, short coiled-coil regions, up to 18 CBS domains, a PB1 domain, and a carboxy-terminal transmembrane domain. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276855 [Multi-domain]  Cd Length: 662  Bit Score: 525.50  E-value: 5.08e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  100 AVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLP-VYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYML----TDRENQSI 174
Cdd:cd14890     2 SLLHTLRLRYERDEIYTYVGPILISINPYKSIPdLYSEERMLLYHGTTAGELPPHVFAIADHAYTQLIqsgvLDPSNQSI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  175 LITGESGAGKTVNTKRVIQY-------FAVIAAIGDRSKKDQSPGK-GTLEDQIIQANPALEAFGNAKTVRNDNSSRFGK 246
Cdd:cd14890    82 IISGESGAGKTEATKIIMQYlaritsgFAQGASGEGEAASEAIEQTlGSLEDRVLSSNPLLESFGNAKTLRNDNSSRFGK 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  247 FIRIHFGATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNnPYDYAFISQGETTVASIDDA 326
Cdd:cd14890   162 FIEIQFDHHGKIVGAEISNFLLEKTRIVTQNDGERNYHIFYQLLAGADEALRERLKLQT-PVEYFYLRGECSSIPSCDDA 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  327 EELMATDNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEA-DKSAYLMGLNSADLLKGLCHPRVK 405
Cdd:cd14890   241 KAFAETIRCLSTIGISEENQDAVFGLLAAVLHLGNVDFESENDTTVLEDATTLQSlKLAAELLGVNEDALEKALLTRQLF 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  406 VGNEYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKL 485
Cdd:cd14890   321 VGGKTIVQPQNVEQARDKRDALAKALYSSLFLWLVSELNRTISSPDDKWGFIGVLDIYGFEKFEWNTFEQLCINYANEKL 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  486 QQFFNHHMFVLEQEEYKKEGIEWTFIDFgMDLQACIDLIE-KPMGIMSILE--EEC--MFPKATDMTFKAKLFDNHLGKS 560
Cdd:cd14890   401 QRHFNQHMFEVEQVEYSNEGIDWQYITF-NDNQACLELIEgKVNGKPGIFItlDDCwrFKGEEANKKFVSQLHASFGRKS 479
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  561 ANFQKPRNIKGKP---------EAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTlfanyagadapi 631
Cdd:cd14890   480 GSGGTRRGSSQHPhfvhpkfdaDKQFGIKHYAGDVIYDASGFNEKNNETLNAEMKELIKQSRRSIREV------------ 547
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  632 ekgkgkakkgssfqTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPN 711
Cdd:cd14890   548 --------------SVGAQFRTQLQELMAKISLTNPRYVRCIKPNETKAPGKFDGLDCLRQLKYSGMMEAIQIRQQGFAL 613
                         650       660       670       680       690
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 124302198  712 RILYGDFRQRYRILNPAAipegqfiDSRKGAEKLLSS-LDIDHNQYKFGHTKVFFK 766
Cdd:cd14890   614 REEHDSFFYDFQVLLPTA-------ENIEQLVAVLSKmLGLGKADWQIGSSKIFLK 662
MYSc_Myo3 cd01379
class III myosin, motor domain; Myosin III has been shown to play a role in the vision process ...
99-766 1.24e-165

class III myosin, motor domain; Myosin III has been shown to play a role in the vision process in insects and in hearing in mammals. Myosin III, an unconventional myosin, does not form dimers. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. They are characterized by an N-terminal protein kinase domain and several IQ domains. Some members also contain WW, SH2, PH, and Y-phosphatase domains. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276830 [Multi-domain]  Cd Length: 633  Bit Score: 520.68  E-value: 1.24e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd01379     1 DTIVSQLQKRYSRDQIYTYIGDILIAVNPFQNLGIYTEEHSRLYRGAKRSDNPPHIFAVADAAYQAMIHQKKNQCIVISG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  179 ESGAGKTVNTKRVIQYFAVIAAIGDRskkdqspgkgTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKL 258
Cdd:cd01379    81 ESGAGKTESANLLVQQLTVLGKANNR----------TLEEKILQVNPLMEAFGNARTVINDNSSRFGKYLEMKFTSTGAV 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  259 ASADIETYLLEKSRVIFQLKAERDYHIFYQIL----SNKKpeLLDMLLITNNPYDY-AFISQGETTVASID-DAEELMAT 332
Cdd:cd01379   151 TGARISEYLLEKSRVVHQAIGERNFHIFYYIYaglaEDKK--LAKYKLPENKPPRYlQNDGLTVQDIVNNSgNREKFEEI 228
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  333 DNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQ----AEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGN 408
Cdd:cd01379   229 EQCFKVIGFTKEEVDSVYSILAAILHIGDIEFTEVESNHQtdksSRISNPEALNNVAKLLGIEADELQEALTSHSVVTRG 308
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  409 EYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATL---ETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKL 485
Cdd:cd01379   309 ETIIRNNTVEEATDARDAMAKALYGRLFSWIVNRINSLLkpdRSASDEPLSIGILDIFGFENFQKNSFEQLCINIANEQI 388
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  486 QQFFNHHMFVLEQEEYKKEGIEWTFIDFGmDLQACID-LIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHlgKSANFQ 564
Cdd:cd01379   389 QYYFNQHIFAWEQQEYLNEGIDVDLIEYE-DNRPLLDmFLQKPMGLLALLDEESRFPKATDQTLVEKFHNNI--KSKYYW 465
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  565 KPRnikgKPEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLStlfanyagadapiekgkgkakkgssf 644
Cdd:cd01379   466 RPK----SNALSFGIHHYAGKVLYDASGFLEKNRDTLPPDVVQLLRSSENPLVR-------------------------- 515
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  645 QTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRI 724
Cdd:cd01379   516 QTVATYFRYSLMDLLSKMVVGQPHFVRCIKPNDSRQAGKFDREKVLKQLRYTGVLETTRIRRQGFSHRILFADFLKRYYF 595
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....
gi 124302198  725 L--NPAAIPEGqfidSRKGAEKLLSSLDIDHnqYKFGHTKVFFK 766
Cdd:cd01379   596 LafKWNEEVVA----NRENCRLILERLKLDN--WALGKTKVFLK 633
MYSc_Myo27 cd14888
class XXVII myosin, motor domain; Not much is known about this myosin class. The catalytic ...
99-766 7.20e-165

class XXVII myosin, motor domain; Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276853 [Multi-domain]  Cd Length: 667  Bit Score: 520.02  E-value: 7.20e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLP-VYTPEVVAAYRgKKRSEAPPHIFSISDNAYQYMLTDRENQSILIT 177
Cdd:cd14888     1 ASILHSLNLRFDIDEIYTFTGPILIAVNPFKTIPgLYSDEMLLKFI-QPSISKSPHVFSTASSAYQGMCNNKKSQTILIS 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  178 GESGAGKTVNTKRVIQYFAViAAIGDRSKKDqspgkgTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHF----- 252
Cdd:cd14888    80 GESGAGKTESTKYVMKFLAC-AGSEDIKKRS------LVEAQVLESNPLLEAFGNARTLRNDNSSRFGKFIELQFsklks 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  253 ----GATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQILS-----------------------NKKPELLDMLLI-T 304
Cdd:cd14888   153 krmsGDRGRLCGAKIQTYLLEKVRVCDQQEGERNYHIFYQLCAaareakntglsyeendeklakgaDAKPISIDMSSFeP 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  305 NNPYDYAFISqGETTVASIDDAEELMATDNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQA---EPDGTEEA 381
Cdd:cd14888   233 HLKFRYLTKS-SCHELPDVDDLEEFESTLYAMQTVGISPEEQNQIFSIVAAILYLGNILFENNEACSEGavvSASCTDDL 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  382 DKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATLE-TKQPRQYFIGVL 460
Cdd:cd14888   312 EKVASLLGVDAEDLLNALCYRTIKTAHEFYTKPLRVDEAEDVRDALARALYSCLFDKVVERTNESIGySKDNSLLFCGVL 391
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  461 DIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGmDLQACIDLI-EKPMGIMSILEEECM 539
Cdd:cd14888   392 DIFGFECFQLNSFEQLCINFTNERLQQFFNNFVFKCEEKLYIEEGISWNPLDFP-DNQDCVDLLqEKPLGIFCMLDEECF 470
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  540 FPKATDMTFKAKLFDNHLGKSaNFQKprnIKGKPEAhFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLST 619
Cdd:cd14888   471 VPGGKDQGLCNKLCQKHKGHK-RFDV---VKTDPNS-FVIVHFAGPVKYCSDGFLEKNKDQLSVDAQEVIKNSKNPFISN 545
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  620 LFANYagadapIEKGKGKAKKGSSFQTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVL 699
Cdd:cd14888   546 LFSAY------LRRGTDGNTKKKKFVTVSSEFRNQLDVLMETIDKTEPHFIRCIKPNSQNVPDLFDRISVNEQLKYGGVL 619
                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 124302198  700 EGIRICRKGFPNRILYGDFRQRYRILNPaaiPEGQfidsrkgaekllssldIDHNQYKFGHTKVFFK 766
Cdd:cd14888   620 QAVQVSRAGYPVRLSHAEFYNDYRILLN---GEGK----------------KQLSIWAVGKTLCFFK 667
MYSc_Myo40 cd14901
class XL myosin, motor domain; The class XL myosins are comprised of Stramenopiles. Not much ...
99-764 6.79e-160

class XL myosin, motor domain; The class XL myosins are comprised of Stramenopiles. Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276866 [Multi-domain]  Cd Length: 655  Bit Score: 505.86  E-value: 6.79e-160
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAY------RGKKRSEAPPHIFSISDNAYQYMLTDRE-- 170
Cdd:cd14901     1 PSILHVLRRRFAHGLIYTSTGAILVAINPFRRLPLYDDETKEAYyehgerRAAGERKLPPHVYAVADKAFRAMLFASRgq 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  171 --NQSILITGESGAGKTVNTKRVIQYfavIAAIGDRSKKDQSPG-KGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKF 247
Cdd:cd14901    81 kcDQSILVSGESGAGKTETTKIIMNY---LASVSSATTHGQNATeRENVRDRVLESNPILEAFGNARTNRNNNSSRFGKF 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  248 IRIHFGATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPyDYAFISQGETTVA--SIDD 325
Cdd:cd14901   158 IRLGFASSGSLLGASISTYLLERVRLVSQAKGERNYHIFYELLRGASSDELHALGLTHVE-EYKYLNSSQCYDRrdGVDD 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  326 AEELMATDNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAY-LMGLNSADLLKGLCHPRV 404
Cdd:cd14901   237 SVQYAKTRHAMTTIGMSPDEQISVLQLVAAVLHLGNLCFVKKDGEGGTFSMSSLANVRAACdLLGLDMDVLEKTLCTREI 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  405 KVGNEYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATLETKQP--RQYFIGVLDIAGFEIFDFNSFEQLCINFTN 482
Cdd:cd14901   317 RAGGEYITMPLSVEQALLTRDVVAKTLYAQLFDWLVDRINESIAYSEStgASRFIGIVDIFGFEIFATNSLEQLCINFAN 396
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  483 EKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDlQACIDLIE-KPMGIMSILEEECMFPKATDMTFKAKLFDNhLGKSA 561
Cdd:cd14901   397 EKLQQLFGKFVFEMEQDEYVAEAIPWTFVEYPNN-DACVAMFEaRPTGLFSLLDEQCLLPRGNDEKLANKYYDL-LAKHA 474
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  562 NFQKPRNIKGKpeAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTlfanyagadapiekgkgkakkg 641
Cdd:cd14901   475 SFSVSKLQQGK--RQFVIHHYAGAVCYATDGFCDKNKDHVHSEALALLRTSSNAFLSS---------------------- 530
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  642 ssfqTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQR 721
Cdd:cd14901   531 ----TVVAKFKVQLSSLLEVLNATEPHFIRCIKPNDVLSPSEFDAKRVLEQLRCSGVLEAVKISRSGYPVRFPHDAFVHT 606
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....*....
gi 124302198  722 YRILNPAAIPEGQFIdsRKGAEKLLSSLDI------DHNQYKFGHTKVF 764
Cdd:cd14901   607 YSCLAPDGASDTWKV--NELAERLMSQLQHselnieHLPPFQVGKTKVF 653
MYSc_Myo9 cd01385
class IX myosin, motor domain; Myosin IX is a processive single-headed motor, which might play ...
102-766 2.16e-158

class IX myosin, motor domain; Myosin IX is a processive single-headed motor, which might play a role in signalling. It has a N-terminal RA domain, an IQ domain, a C1_1 domain, and a RhoGAP domain. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276836 [Multi-domain]  Cd Length: 690  Bit Score: 503.06  E-value: 2.16e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  102 LYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESG 181
Cdd:cd01385     4 LENLRARFKHGKIYTYVGSILIAVNPFKFLPIYNPKYVKMYQNRRLGKLPPHIFAIADVAYHAMLRKKKNQCIVISGESG 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  182 AGKTVNTKRVIQYFAVIaaigdrSKKDQSPGkgtLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASA 261
Cdd:cd01385    84 SGKTESTNFLLHHLTAL------SQKGYGSG---VEQTILGAGPVLEAFGNAKTAHNNNSSRFGKFIQVNYRENGMVRGA 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  262 DIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNnPYDYAFISQGET-TVASIDDAEELMATDNAFDVLG 340
Cdd:cd01385   155 VVEKYLLEKSRIVSQEKNERNYHVFYYLLAGASEEERKELHLKQ-PEDYHYLNQSDCyTLEGEDEKYEFERLKQAMEMVG 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  341 FTSEEKNSMYKLTGAIMHFGNMKFKLK--QREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQ 418
Cdd:cd01385   234 FLPETQRQIFSVLSAVLHLGNIEYKKKayHRDESVTVGNPEVLDIISELLRVKEETLLEALTTKKTVTVGETLILPYKLP 313
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  419 QVIYATGALAKAVYERMFNWMVTRINATLETKQ----PRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMF 494
Cdd:cd01385   314 EAIATRDAMAKCLYSALFDWIVLRINHALLNKKdleeAKGLSIGVLDIFGFEDFGNNSFEQFCINYANEHLQYYFNQHIF 393
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  495 VLEQEEYKKEGIEWTFIDFgMDLQACIDLIE-KPMGIMSILEEECMFPKATDMTFKAKlFDNHLGKSANFQKPRnikgKP 573
Cdd:cd01385   394 KLEQEEYKKEGISWHNIEY-TDNTGCLQLISkKPTGLLCLLDEESNFPGATNQTLLAK-FKQQHKDNKYYEKPQ----VM 467
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  574 EAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLF------------------ANYAGADA------ 629
Cdd:cd01385   468 EPAFIIAHYAGKVKYQIKDFREKNLDLMRPDIVAVLRSSSSAFVRELIgidpvavfrwavlraffrAMAAFREAgrrraq 547
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  630 -----------PIEKGKGKAKKGSSFQTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGV 698
Cdd:cd01385   548 rtaghsltlhdRTTKSLLHLHKKKKPPSVSAQFQTSLSKLMETLGQAEPFFIRCIKSNAEKKPLRFDDELVLRQLRYTGM 627
                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 124302198  699 LEGIRICRKGFPNRILYGDFRQRYRILnpaaIPEGQfIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd01385   628 LETVRIRRSGYSVRYTFQEFITQFQVL----LPKGL-ISSKEDIKDFLEKLNLDRDNYQIGKTKVFLK 690
MYSc_Myo31 cd14892
class XXXI myosin, motor domain; Class XXXI myosins have a very long neck region consisting of ...
105-766 3.00e-152

class XXXI myosin, motor domain; Class XXXI myosins have a very long neck region consisting of 17 IQ motifs and 2 tandem ANK repeats that are separated by a PH domain. The myosin classes XXX to XXXIV contain members from Phytophthora species and Hyaloperonospora parasitica. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276857 [Multi-domain]  Cd Length: 656  Bit Score: 485.03  E-value: 3.00e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  105 LKDRYGSWMIYTYSGLFCVTVNPYKWLP-VYTPEVVAAYRG--KKRSEAPPHIFSISDNAYQYMLTDR----ENQSILIT 177
Cdd:cd14892     7 LRRRYERDAIYTFTADILISINPYKSIPlLYDVPGFDSQRKeeATASSPPPHVFSIAERAYRAMKGVGkgqgTPQSIVVS 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  178 GESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQSPGKG--TLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGAT 255
Cdd:cd14892    87 GESGAGKTEASKYIMKYLATASKLAKGASTSKGAANAheSIEECVLLSNLILEAFGNAKTIRNDNSSRFGKYIQIHYNSD 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  256 GKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKpELLDMLLITNNPYDYAFISQGE-TTVASIDDAEELMATDN 334
Cdd:cd14892   167 GRIAGASTDHFLLEKSRLVGPDANERNYHIFYQLLAGLD-ANENAALELTPAESFLFLNQGNcVEVDGVDDATEFKQLRD 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  335 AFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKL--KQREEQAEPDGTEEADKSAYLMGLNSADLLKGLChPRVKVGneyvT 412
Cdd:cd14892   246 AMEQLGFDAEFQRPIFEVLAAVLHLGNVRFEEnaDDEDVFAQSADGVNVAKAAGLLGVDAAELMFKLV-TQTTST----A 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  413 KGQNVQ------QVIYATGALAKAVYERMFNWMVTRINAtlETKQ------------PRQYFIGVLDIAGFEIFDFNSFE 474
Cdd:cd14892   321 RGSVLEikltarEAKNALDALCKYLYGELFDWLISRINA--CHKQqtsgvtggaaspTFSPFIGILDIFGFEIMPTNSFE 398
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  475 QLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFgMDLQACIDLIEK-PMGIMSILEEECMFP-KATDMTFKAKL 552
Cdd:cd14892   399 QLCINFTNEMLQQQFNKHVFVLEQEVYASEGIDVSAIEF-QDNQDCLDLIQKkPLGLLPLLEEQMLLKrKTTDKQLLTIY 477
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  553 FDNHLGKSANFQKPRNikgkPEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSslkllstlfanyagadapie 632
Cdd:cd14892   478 HQTHLDKHPHYAKPRF----ECDEFVLRHYAGDVTYDVHGFLAKNNDNLHDDLRDLLRSS-------------------- 533
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  633 kgkgkakkgSSFqtvsalhRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNR 712
Cdd:cd14892   534 ---------SKF-------RTQLAELMEVLWSTTPSYIKCIKPNNLKFPGGFSCELVRDQLIYSGVLEVVRIRREGFPIR 597
                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 124302198  713 ILYGDFRQRYRIL-----NPAAIPEGQ--FIDSRKGAEKLLSSLdiDHNQYKFGHTKVFFK 766
Cdd:cd14892   598 RQFEEFYEKFWPLarnkaGVAASPDACdaTTARKKCEEIVARAL--ERENFQLGRTKVFLR 656
MYSc_Myo10 cd14873
class X myosin, motor domain; Myosin X is an unconventional myosin motor that functions as a ...
100-766 3.51e-151

class X myosin, motor domain; Myosin X is an unconventional myosin motor that functions as a monomer. In mammalian cells, the motor is found to localize to filopodia. Myosin X walks towards the barbed ends of filaments and is thought to walk on bundles of actin, rather than single filaments, a unique behavior. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. C-terminal to the head domain are a variable number of IQ domains, 2 PH domains, a MyTH4 domain, and a FERM domain. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276840 [Multi-domain]  Cd Length: 651  Bit Score: 481.99  E-value: 3.51e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  100 AVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLP-VYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd14873     2 SIMYNLFQRYKRNQIYTYIGSILASVNPYQPIAgLYEPATMEQYSRRHLGELPPHIFAIANECYRCLWKRHDNQCILISG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  179 ESGAGKTVNTKRVIQYFAVIA--AIGDRSKKDQSpgkgTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATG 256
Cdd:cd14873    82 ESGAGKTESTKLILKFLSVISqqSLELSLKEKTS----CVEQAILESSPIMEAFGNAKTVYNNNSSRFGKFVQLNICQKG 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  257 KLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITnNPYDYAFISQ-GETTVASIDDAEELMATDNA 335
Cdd:cd14873   158 NIQGGRIVDYLLEKNRVVRQNPGERNYHIFYALLAGLEHEEREEFYLS-TPENYHYLNQsGCVEDKTISDQESFREVITA 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  336 FDVLGFTSEEKNSMYKLTGAIMHFGNMKFklkqreeqAEPDGTEEADK-----SAYLMGLNSADLLKGLCHPRVKVGNEY 410
Cdd:cd14873   237 MEVMQFSKEEVREVSRLLAGILHLGNIEF--------ITAGGAQVSFKtalgrSAELLGLDPTQLTDALTQRSMFLRGEE 308
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  411 VTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQyFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFN 490
Cdd:cd14873   309 ILTPLNVQQAVDSRDSLAMALYARCFEWVIKKINSRIKGKEDFK-SIGILDIFGFENFEVNHFEQFNINYANEKLQEYFN 387
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  491 HHMFVLEQEEYKKEGIEWTFIDFgMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHlGKSANFQKPRnik 570
Cdd:cd14873   388 KHIFSLEQLEYSREGLVWEDIDW-IDNGECLDLIEKKLGLLALINEESHFPQATDSTLLEKLHSQH-ANNHFYVKPR--- 462
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  571 gKPEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADApieKGKGKAKKGSSFQTVSAL 650
Cdd:cd14873   463 -VAVNNFGVKHYAGEVQYDVRGILEKNRDTFRDDLLNLLRESRFDFIYDLFEHVSSRNN---QDTLKCGSKHRRPTVSSQ 538
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  651 HRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNP-AA 729
Cdd:cd14873   539 FKDSLHSLMATLSSSNPFFVRCIKPNMQKMPDQFDQAVVLNQLRYSGMLETVRIRKAGYAVRRPFQDFYKRYKVLMRnLA 618
                         650       660       670
                  ....*....|....*....|....*....|....*..
gi 124302198  730 IPEgqfiDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd14873   619 LPE----DVRGKCTSLLQLYDASNSEWQLGKTKVFLR 651
MYSc_Myo36 cd14897
class XXXVI myosin, motor domain; This class of molluscan myosins contains a motor domain ...
101-766 2.68e-148

class XXXVI myosin, motor domain; This class of molluscan myosins contains a motor domain followed by a GlcAT-I (Beta1,3-glucuronyltransferase I) domain. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276862 [Multi-domain]  Cd Length: 635  Bit Score: 473.41  E-value: 2.68e-148
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  101 VLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKK-RSEAPPHIFSISDNAYQYMLTDRENQSILITGE 179
Cdd:cd14897     3 IVQTLKSRYNKDKFYTYIGDILVAVNPCKPLPIFDKKHHEEYSNLSvRSQRPPHLFWIADQAYRRLLETGRNQCILVSGE 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  180 SGAGKTVNTKRVIQYFAVIaaigdrSKKDQSpgkgTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLA 259
Cdd:cd14897    83 SGAGKTESTKYMIKHLMKL------SPSDDS----DLLDKIVQINPLLEAFGNASTVMNDNSSRFGKFIELHFTENGQLL 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  260 SADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLItNNPYDYAFISQGETTVASIDDAEELMATDNAFDVL 339
Cdd:cd14897   153 GAKIDDYLLEKSRVVHRGNGEKNFHIFYALFAGMSRDRLLYYFL-EDPDCHRILRDDNRNRPVFNDSEELEYYRQMFHDL 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  340 -------GFTSEEKNSMYKLTGAIMHFGNMKFklkqrEEQAEPDGTEEADK-----SAYLMGLNSADLLKGLCHPRVKVG 407
Cdd:cd14897   232 tnimkliGFSEEDISVIFTILAAILHLTNIVF-----IPDEDTDGVTVADEyplhaVAKLLGIDEVELTEALISNVNTIR 306
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  408 NEYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYF-----IGVLDIAGFEIFDFNSFEQLCINFTN 482
Cdd:cd14897   307 GERIQSWKSLRQANDSRDALAKDLYSRLFGWIVGQINRNLWPDKDFQIMtrgpsIGILDMSGFENFKINSFDQLCINLSN 386
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  483 EKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFgMDLQACIDLI-EKPMGIMSILEEECMFPKATDMTFKAKLfDNHLGKSA 561
Cdd:cd14897   387 ERLQQYFNDYVFPRERSEYEIEGIEWRDIEY-HDNDDVLELFfKKPLGILPLLDEESTFPQSTDSSLVQKL-NKYCGESP 464
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  562 NFQKPrnIKGKPEahFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYagadapiekgkgkakkg 641
Cdd:cd14897   465 RYVAS--PGNRVA--FGIRHYAEQVTYDADGFLEKNRDNLSSDIVGCLLNSNNEFISDLFTSY----------------- 523
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  642 ssfqtvsalHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQR 721
Cdd:cd14897   524 ---------FKRSLSDLMTKLNSADPLFVRCIKPNNFLRPNKFDDELVRRQLLCNGLMEIAKIRRDGYPIRIKYEDFVKR 594
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....*..
gi 124302198  722 YRILNPAAIPegqfidSRKGAE-KLLSSLDIDHNQ-YKFGHTKVFFK 766
Cdd:cd14897   595 YKEICDFSNK------VRSDDLgKCQKILKTAGIKgYQFGKTKVFLK 635
MYSc_Myo43 cd14904
class XLIII myosin, motor domain; The class XLIII myosins are comprised of Stramenopiles. Not ...
99-766 1.10e-143

class XLIII myosin, motor domain; The class XLIII myosins are comprised of Stramenopiles. Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276869  Cd Length: 653  Bit Score: 461.33  E-value: 1.10e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLP-VYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILIT 177
Cdd:cd14904     1 PSILFNLKKRFAASKPYTYTNDIVIALNPYKWIDnLYGDHLHEQYLKKPRDKLQPHVYATSTAAYKHMLTNEMNQSILVS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  178 GESGAGKTVNTKRVIQYFAVIAAigdrSKKDQSPGKgtledqIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 257
Cdd:cd14904    81 GESGAGKTETTKIVMNHLASVAG----GRKDKTIAK------VIDVNPLLESFGNAKTTRNDNSSRFGKFTQLQFDGRGK 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  258 LASADIETYLLEKSRVIFQLKAERDYHIFYQILSN-KKPELLDMLLITNNPYDYAFISQGETTVASIDDAEELMATDNAF 336
Cdd:cd14904   151 LIGAKCETYLLEKSRVVSIAEGERNYHIFYQLLAGlSSEERKEFGLDPNCQYQYLGDSLAQMQIPGLDDAKLFASTQKSL 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  337 DVLGFTSEEKNSMYKLTGAIMHFGNMKFkLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQN 416
Cdd:cd14904   231 SLIGLDNDAQRTLFKILSGVLHLGEVMF-DKSDENGSRISNGSQLSQVAKMLGLPTTRIEEALCNRSVVTRNESVTVPLA 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  417 VQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQY-FIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFV 495
Cdd:cd14904   310 PVEAEENRDALAKAIYSKLFDWMVVKINAAISTDDDRIKgQIGVLDIFGFEDFAHNGFEQFCINYANEKLQQKFTTDVFK 389
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  496 LEQEEYKKEGIEWTFIDFgMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNH--LGKSANFQKPRNIKgkp 573
Cdd:cd14904   390 TVEEEYIREGLQWDHIEY-QDNQGIVEVIDGKMGIIALMNDHLRQPRGTEEALVNKIRTNHqtKKDNESIDFPKVKR--- 465
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  574 eAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANyagADAPIEKGKGKA-KKGSSFQTVSALHR 652
Cdd:cd14904   466 -TQFIINHYAGPVTYETVGFMEKHRDTLQNDLLDLVLLSSLDLLTELFGS---SEAPSETKEGKSgKGTKAPKSLGSQFK 541
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  653 ENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPE 732
Cdd:cd14904   542 TSLSQLMDNIKTTNTHYVRCIKPNANKSPTEFDKRMVVEQLRSAGVIEAIRITRSGYPSRLTPKELATRYAIMFPPSMHS 621
                         650       660       670
                  ....*....|....*....|....*....|....*
gi 124302198  733 GqfiDSRKGAEKLLSSLDIDHN-QYKFGHTKVFFK 766
Cdd:cd14904   622 K---DVRRTCSVFMTAIGRKSPlEYQIGKSLIYFK 653
MYSc_Myo39 cd14900
class XXXIX myosin, motor domain; The class XXXIX myosins are found in Stramenopiles. Not much ...
101-731 1.63e-141

class XXXIX myosin, motor domain; The class XXXIX myosins are found in Stramenopiles. Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276865  Cd Length: 627  Bit Score: 454.38  E-value: 1.63e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  101 VLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLP-VYTPEVVAAY-----------RGKKRSEAPPHIFSISDNAYQYM--- 165
Cdd:cd14900     3 ILSALETRFYAQKIYTNTGAILLAVNPFQKLPgLYSSDTMAKYllsfearssstRNKGSDPMPPHIYQVAGEAYKAMmlg 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  166 -LTDRENQSILITGESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQSPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRF 244
Cdd:cd14900    83 lNGVMSDQSILVSGESGSGKTESTKFLMEYLAQAGDNNLAASVSMGKSTSGIAAKVLQTNILLESFGNARTLRNDNSSRF 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  245 GKFIRIHFGATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLdmllitnnpydyafisqgettvaSID 324
Cdd:cd14900   163 GKFIKLHFTSGGRLTGASIQTYLLEKVRLVSQSKGERNYHIFYEMAIGASEAAR-----------------------KRD 219
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  325 DAEELMAtdnAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFK-------LKQREEQAEPDGTEEADKSAYLMGLNSADLLK 397
Cdd:cd14900   220 MYRRVMD---AMDIIGFTPHERAGIFDLLAALLHIGNLTFEhdensdrLGQLKSDLAPSSIWSRDAAATLLSVDATKLEK 296
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  398 GLCHPRVKVGNEYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATL-----ETKQPRQYFIGVLDIAGFEIFDFNS 472
Cdd:cd14900   297 ALSVRRIRAGTDFVSMKLSAAQANNARDALAKALYGRLFDWLVGKMNAFLkmddsSKSHGGLHFIGILDIFGFEVFPKNS 376
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  473 FEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFgMDLQACIDLI-EKPMGIMSILEEECMFPKATDMTFKAK 551
Cdd:cd14900   377 FEQLCINFANETLQQQFNDYVFKAEQREYESQGVDWKYVEF-CDNQDCVNLIsQRPTGILSLIDEECVMPKGSDTTLASK 455
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  552 LFdNHLGKSANFQKPRNIKGKpeAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQksslkllstlfanYAGAdapi 631
Cdd:cd14900   456 LY-RACGSHPRFSASRIQRAR--GLFTIVHYAGHVEYSTDGFLEKNKDVLHQEAVDLFV-------------YGLQ---- 515
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  632 ekgkgkakkgssfqtvsalHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPN 711
Cdd:cd14900   516 -------------------FKEQLTTLLETLQQTNPHYVRCLKPNDLCKAGIYERERVLNQLRCNGVMEAVRVARAGFPI 576
                         650       660
                  ....*....|....*....|
gi 124302198  712 RILYGDFRQRYRILNPAAIP 731
Cdd:cd14900   577 RLLHDEFVARYFSLARAKNR 596
MYSc_Myo28 cd14889
class XXVIII myosin, motor domain; These myosins are found in fish, chicken, and mollusks. The ...
101-766 1.65e-140

class XXVIII myosin, motor domain; These myosins are found in fish, chicken, and mollusks. The tail regions of these class-XXVIII myosins consist of an IQ motif, a short coiled-coil region, and an SH2 domain. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276854  Cd Length: 659  Bit Score: 452.82  E-value: 1.65e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  101 VLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYML----TDRENQSILI 176
Cdd:cd14889     3 LLEVLKVRFMQSNIYTYVGDILVAINPFKYLHIYEKEVSQKYKCEKKSSLPPHIFAVADRAYQSMLgrlaRGPKNQCIVI 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  177 TGESGAGKTVNTKRVIqyfaviaaigdRSKKDQSPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFgATG 256
Cdd:cd14889    83 SGESGAGKTESTKLLL-----------RQIMELCRGNSQLEQQILQVNPLLEAFGNAQTVMNDNSSRFGKYIQLRF-RNG 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  257 KLASADIETYLLEKSRVIFQLKAERDYHIFYQI---LSNKKPELLDMLlitnNPYDYAFISQG---ETTVASIDDA-EEL 329
Cdd:cd14889   151 HVKGAKINEYLLEKSRVVHQDGGEENFHIFYYMfagISAEDRENYGLL----DPGKYRYLNNGagcKREVQYWKKKyDEV 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  330 MatdNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREE-QAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGN 408
Cdd:cd14889   227 C---NAMDMVGFTEQEEVDMFTILAGILSLGNITFEMDDDEAlKVENDSNGWLKAAAGQFGVSEEDLLKTLTCTVTFTRG 303
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  409 EYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQY---FIGVLDIAGFEIFDFNSFEQLCINFTNEKL 485
Cdd:cd14889   304 EQIQRHHTKQQAEDARDSIAKVAYGRVFGWIVSKINQLLAPKDDSSVelrEIGILDIFGFENFAVNRFEQACINLANEQL 383
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  486 QQFFNHHMFVLEQEEYKKEGIEWTFIDFgMDLQACIDL-IEKPMGIMSILEEECMFPKATDMTFKAKLfDNHLGKSANFQ 564
Cdd:cd14889   384 QYFFNHHIFLMEQKEYKKEGIDWKEITY-KDNKPILDLfLNKPIGILSLLDEQSHFPQATDESFVDKL-NIHFKGNSYYG 461
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  565 KPRNIKGKpeahFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADAPIEKGKGKAKKGSSF 644
Cdd:cd14889   462 KSRSKSPK----FTVNHYAGKVTYNASGFLEKNRDTIPASIRTLFINSATPLLSVLFTATRSRTGTLMPRAKLPQAGSDN 537
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  645 ------QTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDF 718
Cdd:cd14889   538 fnstrkQSVGAQFKHSLGVLMEKMFAASPHFVRCIKPNHVKVPGQLDSKYIQDQLRYNGLLETIRIRREGFSWRPSFAEF 617
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....*....
gi 124302198  719 RQRYRIL-NPAAIPegqfiDSRKGAEKLLSSLDIdhNQYKFGHTKVFFK 766
Cdd:cd14889   618 AERYKILlCEPALP-----GTKQSCLRILKATKL--VGWKCGKTRLFFK 659
MYSc_Myo46 cd14907
class XLVI myosin, motor domain; The class XLVI myosins are comprised of Alveolata. Not much ...
101-766 1.18e-138

class XLVI myosin, motor domain; The class XLVI myosins are comprised of Alveolata. Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276872 [Multi-domain]  Cd Length: 669  Bit Score: 447.94  E-value: 1.18e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  101 VLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLP-VYTPEVVAAYRGK--------KRSEAPPHIFSISDNAYQYMLTDREN 171
Cdd:cd14907     3 LLINLKKRYQQDKIFTYVGPTLIVMNPYKQIDnLFSEEVMQMYKEQiiqngeyfDIKKEPPHIYAIAALAFKQLFENNKK 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  172 QSILITGESGAGKTVNTKRVIQYFAVIAA--------IGDRSKKDQ-SPGKGTLEDQIIQANPALEAFGNAKTVRNDNSS 242
Cdd:cd14907    83 QAIVISGESGAGKTENAKYAMKFLTQLSQqeqnseevLTLTSSIRAtSKSTKSIEQKILSCNPILEAFGNAKTVRNDNSS 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  243 RFGKFIRIHFG-ATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNP--YDYAFISQGET- 318
Cdd:cd14907   163 RFGKYVSILVDkKKRKILGARIQNYLLEKSRVTQQGQGERNYHIFYHLLYGADQQLLQQLGLKNQLsgDRYDYLKKSNCy 242
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  319 TVASIDDAEELMATDNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQ--REEQAEPDGTEEADKSAYLMGLNSADLL 396
Cdd:cd14907   243 EVDTINDEKLFKEVQQSFQTLGFTEEEQDSIWRILAAILLLGNLQFDDSTldDNSPCCVKNKETLQIIAKLLGIDEEELK 322
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  397 KGLCHPRVKVGNEYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATL--------ETKQPRQYFIGVLDIAGFEIF 468
Cdd:cd14907   323 EALTTKIRKVGNQVITSPLSKKECINNRDSLSKELYDRLFNWLVERLNDTImpkdekdqQLFQNKYLSIGLLDIFGFEVF 402
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  469 DFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTF--IDFgMDLQACIDLIEK-PMGIMSILEEECMFPKATD 545
Cdd:cd14907   403 QNNSFEQLCINYTNEKLQQLYISYVFKAEEQEFKEEGLEDYLnqLSY-TDNQDVIDLLDKpPIGIFNLLDDSCKLATGTD 481
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  546 MTFKAKLFDNHlGKSANFQKPRNIKGKpeaHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFanYA 625
Cdd:cd14907   482 EKLLNKIKKQH-KNNSKLIFPNKINKD---TFTIRHTAKEVEYNIEGFREKNKDEISQSIINCIQNSKNRIISSIF--SG 555
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  626 GADAPIEKGKGKAKKGSSFQTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRIC 705
Cdd:cd14907   556 EDGSQQQNQSKQKKSQKKDKFLGSKFRNQMKQLMNELMQCDVHFIRCIKPNEEKKADLFIQGYVLNQIRYLGVLESIRVR 635
                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 124302198  706 RKGFPNRILYGDFRQRYRILNpaaipegqfidsrkgaekllssldidhNQYKFGHTKVFFK 766
Cdd:cd14907   636 KQGYPYRKSYEDFYKQYSLLK---------------------------KNVLFGKTKIFMK 669
MYSc_Myo30 cd14891
class XXX myosin, motor domain; Myosins of class XXX are composed of an amino-terminal ...
99-766 3.49e-134

class XXX myosin, motor domain; Myosins of class XXX are composed of an amino-terminal SH3-like domain, two IQ motifs, a coiled-coil region and a PX domain. The myosin classes XXX to XXXIV contain members from Phytophthora species and Hyaloperonospora parasitica. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276856  Cd Length: 645  Bit Score: 434.47  E-value: 3.49e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   99 PAVLYNLKDRYGS--WMIYTYSGLFCVTVNPYKWLPvyTPEVvAAYRGKKRSEAPPHIFSISDNAYQYMLTDRE---NQS 173
Cdd:cd14891     1 AGILHNLEERSKLdnQRPYTFMANVLIAVNPLRRLP--EPDK-SDYINTPLDPCPPHPYAIAEMAYQQMCLGSGrmqNQS 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  174 ILITGESGAGKTVNTKRVIQY--------FAVIAAIGDRSKKDQSPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFG 245
Cdd:cd14891    78 IVISGESGAGKTETSKIILRFlttravggKKASGQDIEQSSKKRKLSVTSLDERLMDTNPILESFGNAKTLRNHNSSRFG 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  246 KFIRIHFGATG-KLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITnNPYDYAFISQ-GETTVASI 323
Cdd:cd14891   158 KFMKLQFTKDKfKLAGAFIETYLLEKSRLVAQPPGERNFHIFYQLLAGASAELLKELLLL-SPEDFIYLNQsGCVSDDNI 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  324 DDAEELMATDNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKlKQREEQAEPDGTEEADK-----SAYLMGLNSADLLKG 398
Cdd:cd14891   237 DDAANFDNVVSALDTVGIDEDLQLQIWRILAGLLHLGNIEFD-EEDTSEGEAEIASESDKealatAAELLGVDEEALEKV 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  399 LCHPRVKVGNEYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFD-FNSFEQLC 477
Cdd:cd14891   316 ITQREIVTRGETFTIKRNAREAVYSRDAIAKSIYERLFLWIVQQINTSLGHDPDPLPYIGVLDIFGFESFEtKNDFEQLL 395
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  478 INFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGmDLQACIDLI-EKPMGIMSILEEECMFPKATDMTFKAKLFDNH 556
Cdd:cd14891   396 INYANEALQATFNQQVFIAEQELYKSEGIDVGVITWP-DNRECLDLIaSKPNGILPLLDNEARNPNPSDAKLNETLHKTH 474
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  557 lGKSANFQKPRNiKGKPEAhFSLIHYAGIVDYNIIGWLQKNKDPLNETvvglyqksslklLSTLFANyagadapiekgkg 636
Cdd:cd14891   475 -KRHPCFPRPHP-KDMREM-FIVKHYAGTVSYTIGSFIDKNNDIIPED------------FEDLLAS------------- 526
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  637 kakkgssfqtvSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYG 716
Cdd:cd14891   527 -----------SAKFSDQMQELVDTLEATRCNFIRCIKPNAAMKVGVFDNRYVVDQLRCSGILQTCEVLKVGLPTRVTYA 595
                         650       660       670       680       690
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 124302198  717 DFRQRYRILNPAAI------PEGQFIdsrkgaEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd14891   596 ELVDVYKPVLPPSVtrlfaeNDRTLT------QAILWAFRVPSDAYRLGRTRVFFR 645
MYSc_Myo41 cd14902
class XLI myosin, motor domain; The class XLI myosins are comprised of Stramenopiles. Not much ...
99-727 3.56e-134

class XLI myosin, motor domain; The class XLI myosins are comprised of Stramenopiles. Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276867 [Multi-domain]  Cd Length: 716  Bit Score: 437.02  E-value: 3.56e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLP-VYTPEVVAAYR--------GKKRSEAPPHIFSISDNAYQYML-TD 168
Cdd:cd14902     1 AALLQALSERFEHDQIYTSIGDILVALNPLKPLPdLYSESQLNAYKasmtstspVSQLSELPPHVFAIGGKAFGGLLkPE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  169 RENQSILITGESGAGKTVNTKRVIQYFAviaAIGDRSKKDQSPGKGTLE--DQIIQANPALEAFGNAKTVRNDNSSRFGK 246
Cdd:cd14902    81 RRNQSILVSGESGSGKTESTKFLMQFLT---SVGRDQSSTEQEGSDAVEigKRILQTNPILESFGNAQTIRNDNSSRFGK 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  247 FIRIHFGATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNpYDYAFISQGETTVA----- 321
Cdd:cd14902   158 FIKIQFGANNEIVGAQIVSYLLEKVRLLHQSPEERSFHIFYELLEGADKTLLDLLGLQKG-GKYELLNSYGPSFArkrav 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  322 SIDDAEELMATDNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEA---DKSAYLMGLNSADLLKG 398
Cdd:cd14902   237 ADKYAQLYVETVRAFEDTGVGELERLDIFKILAALLHLGNVNFTAENGQEDATAVTAASRfhlAKCAELMGVDVDKLETL 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  399 LCHPRVKVGNEYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRIN-------ATLETKQPRQYF--IGVLDIAGFEIFD 469
Cdd:cd14902   317 LSSREIKAGVEVMVLKLTPEQAKEICGSLAKAIYGRLFTWLVRRLSdeinyfdSAVSISDEDEELatIGILDIFGFESLN 396
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  470 FNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLqACIDLIE-KPMGIMSILEEECMFPKATDMTF 548
Cdd:cd14902   397 RNGFEQLCINYANERLQAQFNEFVFVKEQQIYIAEGIDWKNISYPSNA-ACLALFDdKSNGLFSLLDQECLMPKGSNQAL 475
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  549 KAKLFDNHLgksanfqkprnikgkPEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGAD 628
Cdd:cd14902   476 STKFYRYHG---------------GLGQFVVHHFAGRVCYNVEQFVEKNTDALPADASDILSSSSNEVVVAIGADENRDS 540
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  629 APIEKGKGKAKKGSSFQT--VSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICR 706
Cdd:cd14902   541 PGADNGAAGRRRYSMLRApsVSAQFKSQLDRLIVQIGRTEAHYVRCLKPNEVKKPGIFDRERMVEQMRSVGVLEAVRIAR 620
                         650       660
                  ....*....|....*....|.
gi 124302198  707 KGFPNRILYGDFRQRYRILNP 727
Cdd:cd14902   621 HGYSVRLAHASFIELFSGFKC 641
MYSc_Myo47 cd14908
class XLVII myosin, motor domain; The class XLVII myosins are comprised of Stramenopiles. Not ...
99-727 6.92e-132

class XLVII myosin, motor domain; The class XLVII myosins are comprised of Stramenopiles. Not much is known about this myosin class. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276873 [Multi-domain]  Cd Length: 682  Bit Score: 429.33  E-value: 6.92e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYR--GKKRS---EAP----PHIFSISDNAYQYMLTD- 168
Cdd:cd14908     1 PAILHSLSRRFFRGIIYTWTGPVLIAVNPFQRLPLYGKEILESYRqeGLLRSqgiESPqalgPHVFAIADRSYRQMMSEi 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  169 RENQSILITGESGAGKTVNTKRVIQYFAVIAAIGDRSKKD-QSPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKF 247
Cdd:cd14908    81 RASQSILISGESGAGKTESTKIVMLYLTTLGNGEEGAPNEgEELGKLSIMDRVLQSNPILEAFGNARTLRNDNSSRFGKF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  248 IRIHFGATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQIL------SNKKPELLDMLLITNN-PYDYAFISQGET-T 319
Cdd:cd14908   161 IELGFNRAGNLLGAKVQTYLLEKVRLPFHASGERNYHIFYQLLrggdeeEHEKYEFHDGITGGLQlPNEFHYTGQGGApD 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  320 VASIDDAEELMATDNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAY---LMGLNSADLL 396
Cdd:cd14908   241 LREFTDEDGLVYTLKAMRTMGWEESSIDTILDIIAGLLHLGQLEFESKEEDGAAEIAEEGNEKCLARvakLLGVDVDKLL 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  397 KGLCHPRVKVGNEYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATL--ETKQPRQYFIGVLDIAGFEIFDFNSFE 474
Cdd:cd14908   321 RALTSKIIVVRGKEITTKLTPHKAYDARDALAKTIYGALFLWVVATVNSSInwENDKDIRSSVGVLDIFGFECFAHNSFE 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  475 QLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGmDLQACIDLIE-KPMGIMSILEEECMFP-KATDMTFKAKL 552
Cdd:cd14908   401 QLCINFTNEALQQQFNQFIFKLEQKEYEKESIEWAFIEFP-DNQDCLDTIQaKKKGILTMLDDECRLGiRGSDANYASRL 479
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  553 FDNHL-------GKSANFQKPRNIKGKpeAHFSLIHYAGIVDYNI-IGWLQKNKDPLNETVVGLYQKsslkllSTLFany 624
Cdd:cd14908   480 YETYLpeknqthSENTRFEATSIQKTK--LIFAVRHFAGQVQYTVeTTFCEKNKDEIPLTADSLFES------GQQF--- 548
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  625 agadapiekgkgkakkgssfqtvsalhRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRI 704
Cdd:cd14908   549 ---------------------------KAQLHSLIEMIEDTDPHYIRCIKPNDAAKPDLVTRKRVTEQLRYGGVLEAVRV 601
                         650       660
                  ....*....|....*....|...
gi 124302198  705 CRKGFPNRILYGDFRQRYRILNP 727
Cdd:cd14908   602 ARSGYPVRLPHKDFFKRYRMLLP 624
MYSc_Myo35 cd14896
class XXXV myosin, motor domain; This class of metazoan myosins contains 2 IQ motifs, 2 MyTH4 ...
99-766 4.11e-129

class XXXV myosin, motor domain; This class of metazoan myosins contains 2 IQ motifs, 2 MyTH4 domains, a single FERM domain, and an SH3 domain. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276861 [Multi-domain]  Cd Length: 644  Bit Score: 420.34  E-value: 4.11e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd14896     1 SSVLLCLKKRFHLGRIYTFGGPILLSLNPHRSLPLFSEEVLASYHPRKALNTTPHIFAIAASAYRLSQSTGQDQCILLSG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  179 ESGAGKTVNTKRVIQYfavIAAIGDRSKKDQspgkgtlEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFgATGKL 258
Cdd:cd14896    81 HSGSGKTEAAKKIVQF---LSSLYQDQTEDR-------LRQPEDVLPILESFGHAKTILNANASRFGQVLRLHL-QHGVI 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  259 ASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLItNNPYDYAFISQGET-TVASIDDAEELMATDNAFD 337
Cdd:cd14896   150 VGASVSHYLLETSRVVFQAQAERSFHVFYELLAGLDPEEREQLSL-QGPETYYYLNQGGAcRLQGKEDAQDFEGLLKALQ 228
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  338 VLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQRE--EQAEPDGTEEADKSAYLMGLnSADLLKGLCHPRVKVGN-EYVTKG 414
Cdd:cd14896   229 GLGLCAEELTAIWAVLAAILQLGNICFSSSEREsqEVAAVSSWAEIHTAARLLQV-PPERLEGAVTHRVTETPyGRVSRP 307
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  415 QNVQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYF--IGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHH 492
Cdd:cd14896   308 LPVEGAIDARDALAKTLYSRLFTWLLKRINAWLAPPGEAESDatIGVVDAYGFEALRVNGLEQLCINLASERLQLFSSQT 387
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  493 MFVLEQEEYKKEGIEWTFIDfGMDLQACIDLI-EKPMGIMSILEEECMFPKATDMTFKAKLFDNHlGKSANFQKPRNikg 571
Cdd:cd14896   388 LLAQEEEECQRELLPWVPIP-QPPRESCLDLLvDQPHSLLSILDDQTWLSQATDHTFLQKCHYHH-GDHPSYAKPQL--- 462
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  572 kPEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANyagADAPIEKGKGKAKKGSSFQtvsalh 651
Cdd:cd14896   463 -PLPVFTVRHYAGTVTYQVHKFLNRNRDQLDPAVVEMLAQSQLQLVGSLFQE---AEPQYGLGQGKPTLASRFQ------ 532
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  652 rENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILnpAAIP 731
Cdd:cd14896   533 -QSLGDLTARLGRSHVYFIHCLNPNPGKLPGLFDVGHVTEQLRQAGILEAIGTRSEGFPVRVPFQAFLARFGAL--GSER 609
                         650       660       670
                  ....*....|....*....|....*....|....*
gi 124302198  732 EGQFIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd14896   610 QEALSDRERCGAILSQVLGAESPLYHLGATKVLLK 644
PTZ00014 PTZ00014
myosin-A; Provisional
62-819 1.56e-128

myosin-A; Provisional


Pssm-ID: 240229 [Multi-domain]  Cd Length: 821  Bit Score: 424.83  E-value: 1.56e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   62 ETEYGKTVTVKEDQVMQQNPP-KFDKIEDMAMLTFLHEPAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVA 140
Cdd:PTZ00014   72 DPPTNSTFEVKPEHAFNANSQiDPMTYGDIGLLPHTNIPCVLDFLKHRYLKNQIYTTADPLLVAINPFKDLGNTTNDWIR 151
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  141 AYR-GKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFAViAAIGDRSKKDQspgkgtleDQ 219
Cdd:PTZ00014  152 RYRdAKDSDKLPPHVFTTARRALENLHGVKKSQTIIVSGESGAGKTEATKQIMRYFAS-SKSGNMDLKIQ--------NA 222
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  220 IIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLD 299
Cdd:PTZ00014  223 IMAANPVLEAFGNAKTIRNNNSSRFGRFMQLQLGEEGGIRYGSIVAFLLEKSRVVTQEDDERSYHIFYQLLKGANDEMKE 302
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  300 MLLITNNPyDYAFISQGETTVASIDDAEELMATDNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFklKQREEQAEPDGTE 379
Cdd:PTZ00014  303 KYKLKSLE-EYKYINPKCLDVPGIDDVKDFEEVMESFDSMGLSESQIEDIFSILSGVLLLGNVEI--EGKEEGGLTDAAA 379
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  380 EADKS-------AYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATLETKQP 452
Cdd:PTZ00014  380 ISDESlevfneaCELLFLDYESLKKELTVKVTYAGNQKIEGPWSKDESEMLKDSLSKAVYEKLFLWIIRNLNATIEPPGG 459
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  453 RQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGI-----EWTfidfgmDLQACIDLI-EK 526
Cdd:PTZ00014  460 FKVFIGMLDIFGFEVFKNNSLEQLFINITNEMLQKNFVDIVFERESKLYKDEGIsteelEYT------SNESVIDLLcGK 533
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  527 PMGIMSILEEECMFPKATDMTFKAKLFdNHLGKSANFQKPRNIKGKpeaHFSLIHYAGIVDYNIIGWLQKNKDPLNETVV 606
Cdd:PTZ00014  534 GKSVLSILEDQCLAPGGTDEKFVSSCN-TNLKNNPKYKPAKVDSNK---NFVIKHTIGDIQYCASGFLFKNKDVLRPELV 609
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  607 GLYQKSSLKLLSTLFanyagADAPIEKGKGKAKKGSSFQTVsalhrENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDN 686
Cdd:PTZ00014  610 EVVKASPNPLVRDLF-----EGVEVEKGKLAKGQLIGSQFL-----NQLDSLMSLINSTEPHFIRCIKPNENKKPLDWNS 679
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  687 PLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNpAAIPEGQFIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:PTZ00014  680 SKVLIQLHSLSILEALQLRQLGFSYRRTFAEFLSQFKYLD-LAVSNDSSLDPKEKAEKLLERSGLPKDSYAIGKTMVFLK 758
                         730       740       750       760       770
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 124302198  767 AGLLGLLEEMRDERLSR---IITRIQAQSRGVLARmeyKKLLERRDSLLVIQWNIR 819
Cdd:PTZ00014  759 KDAAKELTQIQREKLAAwepLVSVLEALILKIKKK---RKVRKNIKSLVRIQAHLR 811
MYSc_Myo34 cd14895
class XXXIV myosin, motor domain; Class XXXIV myosins are composed of an IQ motif, a short ...
99-766 2.29e-120

class XXXIV myosin, motor domain; Class XXXIV myosins are composed of an IQ motif, a short coiled-coil region, 5 tandem ANK repeats, and a carboxy-terminal FYVE domain. The myosin classes XXX to XXXIV contain members from Phytophthora species and Hyaloperonospora parasitica. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276860 [Multi-domain]  Cd Length: 704  Bit Score: 397.79  E-value: 2.29e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLP-VYTpevVAAYRGK--KRSEAPPHIFSISDNAYQYMLT-------D 168
Cdd:cd14895     1 PAFVDYLAQRYGVDQVYCRSGAVLIAVNPFKHIPgLYD---LHKYREEmpGWTALPPHVFSIAEGAYRSLRRrlhepgaS 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  169 RENQSILITGESGAGKTVNTKRVIQYFAVIA----AIGDRSKKDQSPGkgtleDQIIQANPALEAFGNAKTVRNDNSSRF 244
Cdd:cd14895    78 KKNQTILVSGESGAGKTETTKFIMNYLAESSkhttATSSSKRRRAISG-----SELLSANPILESFGNARTLRNDNSSRF 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  245 GKFIRIHFG-----ATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDML-LITNNPYDYAFISQGET 318
Cdd:cd14895   153 GKFVRMFFEgheldTSLRMIGTSVETYLLEKVRVVHQNDGERNFHVFYELLAGAADDMKLELqLELLSAQEFQYISGGQC 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  319 TVAS--IDDAEELMATDNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGT------------------ 378
Cdd:cd14895   233 YQRNdgVRDDKQFQLVLQSMKVLGFTDVEQAAIWKILSALLHLGNVLFVASSEDEGEEDNGAasapcrlasaspssltvq 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  379 EEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQY--- 455
Cdd:cd14895   313 QHLDIVSKLFAVDQDELVSALTTRKISVGGETFHANLSLAQCGDARDAMARSLYAFLFQFLVSKVNSASPQRQFALNpnk 392
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  456 --------FIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGmDLQACIDLIE-K 526
Cdd:cd14895   393 aankdttpCIAVLDIFGFEEFEVNQFEQFCINYANEKLQYQFIQDILLTEQQAHIEEGIKWNAVDYE-DNSVCLEMLEqR 471
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  527 PMGIMSILEEECMFPKATDMTFKAKLFdNHLGKSANFQKPRniKGKPEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVV 606
Cdd:cd14895   472 PSGIFSLLDEECVVPKGSDAGFARKLY-QRLQEHSNFSASR--TDQADVAFQIHHYAGAVRYQAEGFCEKNKDQPNAELF 548
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  607 GLYQKSSLKLLSTLFANY-AGADAPIEKGKGKAKKGSSFQT---VSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPG 682
Cdd:cd14895   549 SVLGKTSDAHLRELFEFFkASESAELSLGQPKLRRRSSVLSsvgIGSQFKQQLASLLDVVQQTQTHYIRCIKPNDESASD 628
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  683 VMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPegqfidSRKGAEKLLSSLDIDHNQykFGHTK 762
Cdd:cd14895   629 QFDMAKVSSQLRYGGVLKAVEIMRQSYPVRMKHADFVKQYRLLVAAKNA------SDATASALIETLKVDHAE--LGKTR 700

                  ....
gi 124302198  763 VFFK 766
Cdd:cd14895   701 VFLR 704
MYSc_Myo14 cd14876
class XIV myosin, motor domain; These myosins localize to plasma membranes of the ...
99-766 3.13e-119

class XIV myosin, motor domain; These myosins localize to plasma membranes of the intracellular parasites and may be involved in the cell invasion process. Their known functions include: transporting phagosomes to the nucleus and perturbing the developmentally regulated elimination of the macronucleus during conjugation. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. C-terminal to their motor domain these myosins have a MyTH4-FERM protein domain combination. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276843  Cd Length: 649  Bit Score: 392.43  E-value: 3.13e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRG-KKRSEAPPHIFSIS----DNAYQYmltdRENQS 173
Cdd:cd14876     1 PCVLDFLKHRYLKNQIYTTADPLLVAINPFKDLGNATDEWIRKYRDaPDLTKLPPHVFYTArralENLHGV----NKSQT 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  174 ILITGESGAGKTVNTKRVIQYFAViaaigdrSKKDQSPGKgtLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFG 253
Cdd:cd14876    77 IIVSGESGAGKTEATKQIMRYFAS-------AKSGNMDLR--IQTAIMAANPVLEAFGNAKTIRNNNSSRFGRFMQLDVA 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  254 ATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLD--MLLITNnpyDYAFISQGETTVASIDDAEELMA 331
Cdd:cd14876   148 SEGGIRYGSVVAFLLEKSRIVTQDDNERSYHIFYQLLKGADSEMKSkyHLLGLK---EYKFLNPKCLDVPGIDDVADFEE 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  332 TDNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQ-----AEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKV 406
Cdd:cd14876   225 VLESLKSMGLTEEQIDTVFSIVSGVLLLGNVKITGKTEQGVddaaaISNESLEVFKEACSLLFLDPEALKRELTVKVTKA 304
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  407 GNEYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQ 486
Cdd:cd14876   305 GGQEIEGRWTKDDAEMLKLSLAKAMYDKLFLWIIRNLNSTIEPPGGFKNFMGMLDIFGFEVFKNNSLEQLFINITNEMLQ 384
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  487 QFFNHHMFVLEQEEYKKEGI-----EWTfidfgmDLQACID-LIEKPMGIMSILEEECMFPKATDMTFKAKLFDNhLGKS 560
Cdd:cd14876   385 KNFIDIVFERESKLYKDEGIptaelEYT------SNAEVIDvLCGKGKSVLSILEDQCLAPGGSDEKFVSACVSK-LKSN 457
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  561 ANFQKprnIKGKPEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANyagadAPIEKGKGKAKK 640
Cdd:cd14876   458 GKFKP---AKVDSNINFIVVHTIGDIQYNAEGFLFKNKDVLRAELVEVVQASTNPVVKALFEG-----VVVEKGKIAKGS 529
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  641 GSSFQTVSalhreNLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQ 720
Cdd:cd14876   530 LIGSQFLK-----QLESLMGLINSTEPHFIRCIKPNETKKPLEWNSSKVLIQLHALSILEALQLRQLGYSYRRPFEEFLY 604
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....*.
gi 124302198  721 RYRILNPaAIPEGQFIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd14876   605 QFKFLDL-GIANDKSLDPKVAALKLLESSGLSEDEYAIGKTMVFLK 649
MYSc_Myo19 cd14880
class XIX myosin, motor domain; Monomeric myosin-XIX (Myo19) functions as an actin-based motor ...
101-764 6.76e-112

class XIX myosin, motor domain; Monomeric myosin-XIX (Myo19) functions as an actin-based motor for mitochondrial movement in vertebrate cells. It contains a variable number of IQ domains. Human myo19 contains a motor domain, three IQ motifs, and a short tail. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276846 [Multi-domain]  Cd Length: 658  Bit Score: 371.88  E-value: 6.76e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  101 VLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLP-VYTPEVVAAYRGKKRSEA-PPHIFSISDNAYQYMLTDRE--NQSILI 176
Cdd:cd14880     3 VLRCLQARYTADTFYTNAGCTLVALNPFKPVPqLYSPELMREYHAAPQPQKlKPHIFTVGEQTYRNVKSLIEpvNQSIVV 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  177 TGESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQSPGKgtLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATG 256
Cdd:cd14880    83 SGESGAGKTWTSRCLMKFYAVVAASPTSWESHKIAER--IEQRILNSNPVMEAFGNACTLRNNNSSRFGKFIQLQLNRAQ 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  257 KLASADIETYLLEKSRVIFQLKAERDYHIFYQILsnkKPELLDMLLITNNP--YDYAFISQGETTVASiDDAEelmATDN 334
Cdd:cd14880   161 QMTGAAVQTYLLEKTRVACQAPSERNFHIFYQIC---KGASADERLQWHLPegAAFSWLPNPERNLEE-DCFE---VTRE 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  335 AFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQA---EPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYV 411
Cdd:cd14880   234 AMLHLGIDTPTQNNIFKVLAGLLHLGNIQFADSEDEAQPcqpMDDTKESVRTSALLLKLPEDHLLETLQIRTIRAGKQQQ 313
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  412 TKGQNVQQVIYAT--GALAKAVYERMFNWMVTRINATLETKQPR-QYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQF 488
Cdd:cd14880   314 VFKKPCSRAECDTrrDCLAKLIYARLFDWLVSVINSSICADTDSwTTFIGLLDVYGFESFPENSLEQLCINYANEKLQQH 393
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  489 FNHHMFVLEQEEYKKEGIEWTFIDFgMDLQACIDLIE-KPMGIMSILEEECMFPKATDmtfkAKLFDNHLGKS-ANFQKP 566
Cdd:cd14880   394 FVAHYLRAQQEEYAVEGLEWSFINY-QDNQTCLDLIEgSPISICSLINEECRLNRPSS----AAQLQTRIESAlAGNPCL 468
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  567 RNIKGKPEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADAPIEkgkGKAKKGSSFQT 646
Cdd:cd14880   469 GHNKLSREPSFIVVHYAGPVRYHTAGLVEKNKDPVPPELTRLLQQSQDPLLQKLFPANPEEKTQEE---PSGQSRAPVLT 545
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  647 VSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRIL- 725
Cdd:cd14880   546 VVSKFKASLEQLLQVLHSTTPHYIRCIKPNSQCQAQTFLQEEVLSQLEACGLVETIHISAAGFPIRVSHQNFVERYKLLr 625
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|.
gi 124302198  726 --NPAAIPEGQFIDSRKGAEKLLSSldidhnqykfGHTKVF 764
Cdd:cd14880   626 rlRPHTSSGPHSPYPAKGLSEPVHC----------GRTKVF 656
MYSc_Myo38 cd14899
class XXXVIII myosin; The class XXXVIII myosins are comprised of Stramenopiles. Not much is ...
100-723 5.14e-107

class XXXVIII myosin; The class XXXVIII myosins are comprised of Stramenopiles. Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276864 [Multi-domain]  Cd Length: 717  Bit Score: 359.79  E-value: 5.14e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  100 AVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLP-VYTPEVVAAYR-------GKKRSEA---PPHIFSISDNAYQYMLTD 168
Cdd:cd14899     2 SILNALRLRYERHAIYTHIGDILISINPFQDLPqLYGDEILRGYAydhnsqfGDRVTSTdprEPHLFAVARAAYIDIVQN 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  169 RENQSILITGESGAGKTVNTKRVIQYFAV-------IAAIGDRSKKDQSPGKGTLEDQIIQANPALEAFGNAKTVRNDNS 241
Cdd:cd14899    82 GRSQSILISGESGAGKTEATKIIMTYFAVhcgtgnnNLTNSESISPPASPSRTTIEEQVLQSNPILEAFGNARTVRNDNS 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  242 SRFGKFIRIHF-GATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNK----KPELLDMLLITNNPYDYAFISQG 316
Cdd:cd14899   162 SRFGKFIELRFrDERRRLAGARIRTYLLEKIRVIKQAPHERNFHIFYELLSADnncvSKEQKQVLALSGGPQSFRLLNQS 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  317 ETTVA--SIDDAEELMATDNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKL--KQREEQAEPDGTEEA----------D 382
Cdd:cd14899   242 LCSKRrdGVKDGVQFRATKRAMQQLGMSEGEIGGVLEIVAAVLHMGNVDFEQipHKGDDTVFADEARVMssttgafdhfT 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  383 KSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQY------- 455
Cdd:cd14899   322 KAAELLGVSTEALDHALTKRWLHASNETLVVGVDVAHARNTRNALTMECYRLLFEWLVARVNNKLQRQASAPWgadesdv 401
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  456 --------FIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDlQACIDLIE-K 526
Cdd:cd14899   402 ddeedatdFIGLLDIFGFEDMAENSFEQLCINYANEALQHQFNQYIFEEEQRLYRDEGIRWSFVDFPNN-RACLELFEhR 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  527 PMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSANFQKPRNIKGKPEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVV 606
Cdd:cd14899   481 PIGIFSLTDQECVFPQGTDRALVAKYYLEFEKKNSHPHFRSAPLIQRTTQFVVAHYAGCVTYTIDGFLAKNKDSFCESAA 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  607 GLYQKSSLKLLSTLFANYAGADAPIEKGKGKAKKGSSFQTVSAL--------HRENLNKLMTNLRSTHPHFVRCIIPNET 678
Cdd:cd14899   561 QLLAGSSNPLIQALAAGSNDEDANGDSELDGFGGRTRRRAKSAIaavsvgtqFKIQLNELLSTVRATTPRYVRCIKPNDS 640
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....*
gi 124302198  679 KSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYR 723
Cdd:cd14899   641 HVGSLFQSTRVVEQLRSGGVLEAVRVARAGFPVRLTHKQFLGRYR 685
MYSc_Myo13 cd14875
class XIII myosin, motor domain; These myosins have an N-terminal motor domain, a light-chain ...
101-766 2.83e-106

class XIII myosin, motor domain; These myosins have an N-terminal motor domain, a light-chain binding domain, and a C-terminal GPA/Q-rich domain. There is little known about the function of this myosin class. Two of the earliest members identified in this class are green alga Acetabularia cliftonii, Aclmyo1 and Aclmyo2. They are striking with their short tail of Aclmyo1 of 18 residues and the maximum of 7 IQ motifs in Aclmyo2. It is thought that these myosins are involved in organelle transport and tip growth. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276842 [Multi-domain]  Cd Length: 664  Bit Score: 356.04  E-value: 2.83e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  101 VLYNLKDRYGSWMI-YTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEA-PPHIFSISDNAY-QYMLTDRENQSILIT 177
Cdd:cd14875     3 LLHCIKERFEKLHQqYSLMGEMVLSVNPFRLMPFNSEEERKKYLALPDPRLlPPHIWQVAHKAFnAIFVQGLGNQSVVIS 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  178 GESGAGKTVNTKRVIQYFAVIAAIgdRSKkdqSPGKGTLEDQIIQ----ANPALEAFGNAKTVRNDNSSRFGKFIRIHF- 252
Cdd:cd14875    83 GESGSGKTENAKMLIAYLGQLSYM--HSS---NTSQRSIADKIDEnlkwSNPVMESFGNARTVRNDNSSRFGKYIKLYFd 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  253 GATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTV------ASIDDA 326
Cdd:cd14875   158 PTSGVMVGGQTVTYLLEKSRIIMQSPGERNYHIFYEMLAGLSPEEKKELGGLKTAQDYKCLNGGNTFVrrgvdgKTLDDA 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  327 EELMATDNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEAdKSAYLMGLNSADLLKGLChprVKV 406
Cdd:cd14875   238 HEFQNVRHALSMIGVELETQNSIFRVLASILHLMEVEFESDQNDKAQIADETPFL-TACRLLQLDPAKLRECFL---VKS 313
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  407 GNEYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATLetkQPRQ-----YFIGVLDIAGFEIFDFNSFEQLCINFT 481
Cdd:cd14875   314 KTSLVTILANKTEAEGFRNAFCKAIYVGLFDRLVEFVNASI---TPQGdcsgcKYIGLLDIFGFENFTRNSFEQLCINYA 390
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  482 NEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGmDLQACIDLIE-KPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKS 560
Cdd:cd14875   391 NESLQNHYNKYTFINDEEECRREGIQIPKIEFP-DNSECVNMFDqKRTGIFSMLDEECNFKGGTTERFTTNLWDQWANKS 469
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  561 ANFQKPrniKGKPEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADapiekgkgkakk 640
Cdd:cd14875   470 PYFVLP---KSTIPNQFGVNHYAAFVNYNTDEWLEKNTDALKEDMYECVSNSTDEFIRTLLSTEKGLA------------ 534
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  641 gSSFQTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDF-R 719
Cdd:cd14875   535 -RRKQTVAIRFQRQLTDLRTELESTETQFIRCIKPNMEASPSFLDNLLVGSQLESAGVLQTIALKRQGYPVRRPIEQFcR 613
                         650       660       670       680       690
                  ....*....|....*....|....*....|....*....|....*....|.
gi 124302198  720 QRYRILNPAAIPEGQFIDSRKGAEKLLSSLDIDHN----QYKFGHTKVFFK 766
Cdd:cd14875   614 YFYLIMPRSTASLFKQEKYSEAAKDFLAYYQRLYGwakpNYAVGKTKVFLR 664
MYSc_Myo45 cd14906
class XLV myosin, motor domain; The class XLVI myosins are comprised of slime molds ...
101-726 9.23e-106

class XLV myosin, motor domain; The class XLVI myosins are comprised of slime molds Dictyostelium and Polysphondylium. Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276871 [Multi-domain]  Cd Length: 715  Bit Score: 356.21  E-value: 9.23e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  101 VLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLP-VYTPEVVAAYRGKKR-SEAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd14906     3 ILNNLGKRYKSDSIYTYIGNVLISINPYKDISsIYSNLILNEYKDINQnKSPIPHIYAVALRAYQSMVSEKKNQSIIISG 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  179 ESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQSPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGAT-GK 257
Cdd:cd14906    83 ESGSGKTEASKTILQYLINTSSSNQQQNNNNNNNNNSIEKDILTSNPILEAFGNSRTTKNHNSSRFGKFLKIEFRSSdGK 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  258 LASADIETYLLEKSRVIFQL-KAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASI------------- 323
Cdd:cd14906   163 IDGASIETYLLEKSRISHRPdNINLSYHIFYYLVYGASKDERSKWGLNNDPSKYRYLDARDDVISSFksqssnknsnhnn 242
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  324 --DDAEELMATDNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQ---REEQAEPDGTEEADKSAYLMGLNSADLLKG 398
Cdd:cd14906   243 ktESIESFQLLKQSMESMSINKEQCDAIFLSLAAILHLGNIEFEEDSdfsKYAYQKDKVTASLESVSKLLGYIESVFKQA 322
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  399 LCHPRVKVGNE--YVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINAT-LETKQPRQ----------YFIGVLDIAGF 465
Cdd:cd14906   323 LLNRNLKAGGRgsVYCRPMEVAQSEQTRDALSKSLYVRLFKYIVEKINRKfNQNTQSNDlaggsnkknnLFIGVLDIFGF 402
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  466 EIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFgMDLQACIDLIE-KPMGIMSILEEECMFPKAT 544
Cdd:cd14906   403 ENLSSNSLEQLLINFTNEKLQQQFNLNVFENEQKEYLSEGIPWSNSNF-IDNKECIELIEkKSDGILSLLDDECIMPKGS 481
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  545 DMTFKAKLfdNHLGKSANFQKPRNI-KGKpeahFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFan 623
Cdd:cd14906   482 EQSLLEKY--NKQYHNTNQYYQRTLaKGT----LGIKHFAGDVTYQTDGWLEKNRDSLYSDVEDLLLASSNFLKKSLF-- 553
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  624 yagaDAPIEKGKGKAKKGSSFQTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIR 703
Cdd:cd14906   554 ----QQQITSTTNTTKKQTQSNTVSGQFLEQLNQLIQTINSTSVHYIRCIKPNQTMDCNNFNNVHVLSQLRNVGVLNTIK 629
                         650       660
                  ....*....|....*....|...
gi 124302198  704 ICRKGFPNRILYGDFRQRYRILN 726
Cdd:cd14906   630 VRKMGYSYRRDFNQFFSRYKCIV 652
MYSc_Myo18 cd01386
class XVIII myosin, motor domain; Many members of this class contain a N-terminal PDZ domain ...
101-766 1.92e-103

class XVIII myosin, motor domain; Many members of this class contain a N-terminal PDZ domain which is commonly found in proteins establishing molecular complexes. The motor domain itself does not exhibit ATPase activity, suggesting that it functions as an actin tether protein. It also has two IQ domains that probably bind light chains or related calmodulins and a C-terminal tail with two sections of coiled-coil domains, which are thought to mediate homodimerization. The function of these myosins are largely unknown. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276837 [Multi-domain]  Cd Length: 689  Bit Score: 348.53  E-value: 1.92e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  101 VLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGES 180
Cdd:cd01386     3 VLHTLRQRYGANLIHTYAGPSLIVINPRHPLAVYSEKVAKMFKGCRREDMPPHIYASAQSAYRAMLMSRRDQSIVLLGRS 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  181 GAGKTVNTKRVIQYFAVIAAIgdrSKKDQSPGKgtledqiIQA-NPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLA 259
Cdd:cd01386    83 GSGKTTNCRHILEYLVTAAGS---VGGVLSVEK-------LNAaLTVLEAFGNVRTALNGNATRFSQLFSLDFDQAGQLA 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  260 SADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFisqGETTVASIDD----AEELMATDNA 335
Cdd:cd01386   153 SASIQTLLLERSRVARRPEGESNFNVFYYLLAGADAALRTELHLNQLAESNSF---GIVPLQKPEDkqkaAAAFSKLQAA 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  336 FDVLGFTSEEKNSMYKLTGAIMHFGN---MKFKLKQREEQAEPdgtEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVT 412
Cdd:cd01386   230 MKTLGISEEEQRAIWSILAAIYHLGAagaTKAASAGRKQFARP---EWAQRAAYLLGCTLEELSSAIFKHHLSGGPQQST 306
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  413 ---------------KGQNVQQviyATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFN------ 471
Cdd:cd01386   307 tssgqesparsssggPKLTGVE---ALEGFAAGLYSELFAAVVSLINRSLSSSHHSTSSITIVDTPGFQNPAHSgsqrga 383
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  472 SFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLQACIDLIEK---------------PMGIMSILEE 536
Cdd:cd01386   384 TFEDLCHNYAQERLQLLFHERTFVAPLERYKQENVEVDFDLPELSPGALVALIDQapqqalvrsdlrdedRRGLLWLLDE 463
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  537 ECMFPKATDMTFKAKLFdNHLGKSANFQKPRNIKGKPEA-HFSLIHYAGI--VDYNIIGWLQKNK-DPLNETVVGLYQKS 612
Cdd:cd01386   464 EALYPGSSDDTFLERLF-SHYGDKEGGKGHSLLRRSEGPlQFVLGHLLGTnpVEYDVSGWLKAAKeNPSAQNATQLLQES 542
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  613 SlKLLSTLFANYAGADApiekgkgkakkgsSFQtvsalhrenLNKLMTNLRSTHPHFVRCIIPN------------ETKS 680
Cdd:cd01386   543 Q-KETAAVKRKSPCLQI-------------KFQ---------VDALIDTLRRTGLHFVHCLLPQhnagkderstssPAAG 599
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  681 PGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPA----AIPEGQFIDSRKGAEKLLSSLDIDHNQY 756
Cdd:cd01386   600 DELLDVPLLRSQLRGSQLLDALRLYRQGFPDHMPLGEFRRRFQVLAPPltkkLGLNSEVADERKAVEELLEELDLEKSSY 679
                         730
                  ....*....|
gi 124302198  757 KFGHTKVFFK 766
Cdd:cd01386   680 RIGLSQVFFR 689
MYSc_Myo25 cd14886
class XXV myosin, motor domain; These myosins are MyTH-FERM myosins that play a role in cell ...
105-766 5.45e-103

class XXV myosin, motor domain; These myosins are MyTH-FERM myosins that play a role in cell adhesion and filopodia formation. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276851  Cd Length: 650  Bit Score: 345.72  E-value: 5.45e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  105 LKDRYGSWMIYTYSGLFCVTVNPYKWLP-VYTPEVVAAYRGKKRS-----EAPPHIFSISDNAYQYMLTDRENQSILITG 178
Cdd:cd14886     7 LRDRFAKDKIYTYAGKLLVALNPFKQIRnLYGTEVIGRYRQADTSrgfpsDLPPHSYAVAQSALNGLISDGISQSCIVSG 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  179 ESGAGKTVNTKRVIQYFAViaaigdrskkDQSPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKL 258
Cdd:cd14886    87 ESGAGKTETAKQLMNFFAY----------GHSTSSTDVQSLILGSNPLLESFGNAKTLRNNNSSRFGKFIKLLVGPDGGL 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  259 ASADIETYLLEKSRVIFQLKAERDYHIFYQI---LSNKKPELLDMLLITNnpydYAFISQGET-TVASIDDAEELMATDN 334
Cdd:cd14886   157 KGGKITSYMLELSRIEFQSTNERNYHIFYQCikgLSPEEKKSLGFKSLES----YNFLNASKCyDAPGIDDQKEFAPVRS 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  335 AFDVLgFTSEEKNSMYKLTGAIMHFGNMKFKLKQR---EEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYV 411
Cdd:cd14886   233 QLEKL-FSKNEIDSFYKCISGILLAGNIEFSEEGDmgvINAAKISNDEDFGKMCELLGIESSKAAQAIITKVVVINNETI 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  412 TKGQNVQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNH 491
Cdd:cd14886   312 ISPVTQAQAEVNIRAVAKDLYGALFELCVDTLNEIIQFDADARPWIGILDIYGFEFFERNTYEQLLINYANERLQQYFIN 391
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  492 HMFVLEQEEYKKEGIEWTFIDFgMDLQACIDLIEKP-MGIMSILEEECMFPKATDMTFKAKLfDNHLgKSANFqkprnIK 570
Cdd:cd14886   392 QVFKSEIQEYEIEGIDHSMITF-TDNSNVLAVFDKPnLSIFSFLEEQCLIQTGSSEKFTSSC-KSKI-KNNSF-----IP 463
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  571 GKPEA-HFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLstlfaNYAGADAPIEKGKGKAkkgssfQTVSA 649
Cdd:cd14886   464 GKGSQcNFTIVHTAATVTYNTEEFVDKNKHKLSVDILELLMGSTNPIV-----NKAFSDIPNEDGNMKG------KFLGS 532
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  650 LHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRIL---N 726
Cdd:cd14886   533 TFQLSIDQLMKTLSATKSHFIRCIKTNQDKVPNKYETKSVYNQLISLSIFESIQTIHRGFAYNDTFEEFFHRNKILishN 612
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|
gi 124302198  727 PAAIPEGQfiDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd14886   613 SSSQNAGE--DLVEAVKSILENLGIPCSDYRIGKTKVFLR 650
MYSc_Myo37 cd14898
class XXXVII myosin, motor domain; The class XXXVIII myosins are comprised of fungi. Not much ...
100-741 5.43e-96

class XXXVII myosin, motor domain; The class XXXVIII myosins are comprised of fungi. Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276863  Cd Length: 578  Bit Score: 323.00  E-value: 5.43e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  100 AVLYNLKDRYGSWMIYTYSGLFCVTVNPYKwlPVYTPEVVAAYRgKKRSEAPPHIFSISDNAYQYMLTdRENQSILITGE 179
Cdd:cd14898     2 ATLEILEKRYASGKIYTKSGLVFLALNPYE--TIYGAGAMKAYL-KNYSHVEPHVYDVAEASVQDLLV-HGNQTIVISGE 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  180 SGAGKTVNTKRVIQYFAviaaigdrskkDQSPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFgaTGKLA 259
Cdd:cd14898    78 SGSGKTENAKLVIKYLV-----------ERTASTTSIEKLITAANLILEAFGNAKTQLNDNSSRFGKRIKLKF--DGKIT 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  260 SADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKpelldmLLITNNPYDYAFISQGETTVasIDDAEELMATDNAFDVL 339
Cdd:cd14898   145 GAKFETYLLEKSRVTHHEKGERNFHIFYQFCASKR------LNIKNDFIDTSSTAGNKESI--VQLSEKYKMTCSAMKSL 216
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  340 GFTSEEknSMYKLTGAIMHFGNMKFklkQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQQ 419
Cdd:cd14898   217 GIANFK--SIEDCLLGILYLGSIQF---VNDGILKLQRNESFTEFCKLHNIQEEDFEESLVKFSIQVKGETIEVFNTLKQ 291
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  420 VIYATGALAKAVYERMFNWMVTRINATLETKQPRQyfIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQE 499
Cdd:cd14898   292 ARTIRNSMARLLYSNVFNYITASINNCLEGSGERS--ISVLDIFGFEIFESNGLDQLCINWTNEKIQNDFIKKMFRAKQG 369
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  500 EYKKEGIEWTFIDFgMDLQACIDLIEKPMGIMSILEEECMFPKAT--DMTFKAKLFDNHlgksanfqkprNIKGKPEAHF 577
Cdd:cd14898   370 MYKEEGIEWPDVEF-FDNNQCIRDFEKPCGLMDLISEESFNAWGNvkNLLVKIKKYLNG-----------FINTKARDKI 437
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  578 SLIHYAGIVDYNIIGWLQKNKdplnetvvglyQKSSLKLLSTLFANYAGadapiekgkgkakkgsSFQTVSALHRENLNK 657
Cdd:cd14898   438 KVSHYAGDVEYDLRDFLDKNR-----------EKGQLLIFKNLLINDEG----------------SKEDLVKYFKDSMNK 490
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  658 LMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIpegQFID 737
Cdd:cd14898   491 LLNSINETQAKYIKCIRPNEECRPWCFDRDLVSKQLAECGILETIRLSKQCFPQEIPKDRFEERYRILGITLF---EVVD 567

                  ....
gi 124302198  738 SRKG 741
Cdd:cd14898   568 YRKG 571
MYSc_Myo16 cd14878
class XVI myosin, motor domain; These XVI type myosins are also known as Neuronal ...
100-725 2.78e-95

class XVI myosin, motor domain; These XVI type myosins are also known as Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 3/NYAP3. Myo16 is thought to play a regulatory role in cell cycle progression and has been recently implicated in Schizophrenia. Class XVI myosins are characterized by an N-terminal ankyrin repeat domain and some with chitin synthase domains that arose independently from the ones in the class XVII fungal myosins. They bind protein phosphatase 1 catalytic subunits 1alpha/PPP1CA and 1gamma/PPP1CC. Human Myo16 interacts with ACOT9, ARHGAP26 and PIK3R2 and with components of the WAVE1 complex, CYFIP1 and NCKAP1. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276844 [Multi-domain]  Cd Length: 656  Bit Score: 323.69  E-value: 2.78e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  100 AVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYR---GKKRSEAPPHIFSISDNAYQYMLTDRENQSILI 176
Cdd:cd14878     2 SLLYEIQKRFGNNQIYTFIGDILLLVNPYKELPIYSTMVSQLYLsssGQLCSSLPPHLFSCAERAFHQLFQERRPQCFIL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  177 TGESGAGKTVNTKRVIQYFAViaaigdRSkkdqSPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATG 256
Cdd:cd14878    82 SGERGSGKTEASKQIMKHLTC------RA----SSSRTTFDSRFKHVNCILEAFGHAKTTLNDLSSCFIKYFELQFCERK 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  257 K-LASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLItNNPYDYAFISQGE----TTVASIDDAEELMA 331
Cdd:cd14878   152 KhLTGARIYTYMLEKSRLVSQPPGQSNFLIFYLLMDGLSAEEKYGLHL-NNLCAHRYLNQTMredvSTAERSLNREKLAV 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  332 TDNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYV 411
Cdd:cd14878   231 LKQALNVVGFSSLEVENLFVILSAILHLGDIRFTALTEADSAFVSDLQLLEQVAGMLQVSTDELASALTTDIQYFKGDMI 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  412 TKGQNVQQVIYATGALAKAVYERMFNWMVTRINATL----ETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQ 487
Cdd:cd14878   311 IRRHTIQIAEFYRDLLAKSLYSRLFSFLVNTVNCCLqsqdEQKSMQTLDIGILDIFGFEEFQKNEFEQLCVNMTNEKMHH 390
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  488 FFNHHMFVLEQEEYKKEGIEWTFIDFGMDLQACIDLI-EKPMGIMSILEEECMFPKATDMTFKAKLfdNHLGKSANFQ-- 564
Cdd:cd14878   391 YINEVLFLQEQTECVQEGVTMETAYSPGNQTGVLDFFfQKPSGFLSLLDEESQMIWSVEPNLPKKL--QSLLESSNTNav 468
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  565 ----KPRNIKGKPEAH---FSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFanyagadapiekgkgk 637
Cdd:cd14878   469 yspmKDGNGNVALKDQgtaFTVMHYAGRVMYEIVGAIEKNKDSLSQNLLFVMKTSENVVINHLF---------------- 532
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  638 akkGSSFQTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGD 717
Cdd:cd14878   533 ---QSKLVTIASQLRKSLADIIGKLQKCTPHFIHCIKPNNSKLPDTFDNFYVSAQLQYIGVLEMVKIFRYGYPVRLSFSD 609

                  ....*...
gi 124302198  718 FRQRYRIL 725
Cdd:cd14878   610 FLSRYKPL 617
MYSc_Myo26 cd14887
class XXVI myosin, motor domain; These MyTH-FERM myosins are thought to be related to the ...
99-766 8.16e-91

class XXVI myosin, motor domain; These MyTH-FERM myosins are thought to be related to the other myosins that have a MyTH4 domain such as class III, VII, IX, X , XV, XVI, XVII, XX, XXII, XXV, and XXXIV. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276852  Cd Length: 725  Bit Score: 312.74  E-value: 8.16e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   99 PAVLYNLKDRYGS--------WMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRE 170
Cdd:cd14887     1 PNLLENLYQRYNKayinkenrNCIYTYTGTLLIAVNPYRFFNLYDRQWISRFDTEANSRLVPHPFGLAEFAYCRLVRDRR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  171 NQSILITGESGAGKTVNTKRVIQYfavIAAIGDRSKKDQSPGkgtLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRI 250
Cdd:cd14887    81 SQSILISGESGAGKTETSKHVLTY---LAAVSDRRHGADSQG---LEARLLQSGPVLEAFGNAHTVLNANSSRFGKMLLL 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  251 HFGATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKK-PELLDMLLITNNPYDYafisqgettvasiddaeEL 329
Cdd:cd14887   155 HFTGRGKLTRASVATYLLANERVVRIPSDEFSFHIFYALCNAAVaAATQKSSAGEGDPEST-----------------DL 217
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  330 MATDNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPD-------GTEE--ADKS--AYLMGLNS------ 392
Cdd:cd14887   218 RRITAAMKTVGIGGGEQADIFKLLAAILHLGNVEFTTDQEPETSKKRkltsvsvGCEEtaADRShsSEVKCLSSglkvte 297
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  393 ------ADLLKGLCHPRVKVGNEYV------------TKGQNVQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQ 454
Cdd:cd14887   298 asrkhlKTVARLLGLPPGVEGEEMLrlalvsrsvretRSFFDLDGAAAARDAACKNLYSRAFDAVVARINAGLQRSAKPS 377
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  455 Y--------------FIGVLDIAGFEIF---DFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEG--IEWTFIDFGM 515
Cdd:cd14887   378 EsdsdedtpsttgtqTIGILDLFGFEDLrnhSKNRLEQLCINYANERLHCFLLEQLILNEHMLYTQEGvfQNQDCSAFPF 457
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  516 DLQACIDLIEKP------------------------MGIMSILEEE-CMFPKATDMTFKAKLFDNHLGKSA-NFQKPRNI 569
Cdd:cd14887   458 SFPLASTLTSSPsstspfsptpsfrsssafatspslPSSLSSLSSSlSSSPPVWEGRDNSDLFYEKLNKNIiNSAKYKNI 537
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  570 K---GKPEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYqksslkllstLFANYAGADAPIEKGKGKAKKGSSFQT 646
Cdd:cd14887   538 TpalSRENLEFTVSHFACDVTYDARDFCRANREATSDELERLF----------LACSTYTRLVGSKKNSGVRAISSRRST 607
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  647 VSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILN 726
Cdd:cd14887   608 LSAQFASQLQQVLKALQETSCHFIRCVKPNRVQEAGIFEDAYVHRQLRCSGMSDLLRVMADGFPCRLPYVELWRRYETKL 687
                         730       740       750       760
                  ....*....|....*....|....*....|....*....|
gi 124302198  727 PAAIPEgqFIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFK 766
Cdd:cd14887   688 PMALRE--ALTPKMFCKIVLMFLEINSNSYTFGKTKIFFR 725
MYSc_Myo24A cd14937
class XXIV A myosin, motor domain; These myosins have a 1-2 IQ motifs in their neck and a ...
101-766 2.26e-85

class XXIV A myosin, motor domain; These myosins have a 1-2 IQ motifs in their neck and a coiled-coil region in their C-terminal tail. The function of the class XXIV myosins remain elusive. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276897  Cd Length: 637  Bit Score: 294.23  E-value: 2.26e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  101 VLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEvvaaYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGES 180
Cdd:cd14937     3 VLNMLALRYKKNYIYTIAEPMLISINPYQVIDVDINE----YKNKNTNELPPHVYSYAKDAMTDFINTKTNQSIIISGES 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  181 GAGKTVNTKRVIQYFavIAAIgdrsKKDQSPGKgTLEDqiiqANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLAS 260
Cdd:cd14937    79 GSGKTEASKLVIKYY--LSGV----KEDNEISN-TLWD----SNFILEAFGNAKTLKNNNSSRYGKYIKIELDEYQNIVS 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  261 ADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPyDYAFISQGETTVASIDDAEELMATDNAFDVLG 340
Cdd:cd14937   148 SSIEIFLLENIRVVSQEEEERGYHIFYQIFNGMSQELKNKYKIRSEN-EYKYIVNKNVVIPEIDDAKDFGNLMISFDKMN 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  341 FTSEEKNSMYKLTGAIMhFGNMKFKL-----KQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQ 415
Cdd:cd14937   227 MHDMKDDLFLTLSGLLL-LGNVEYQEiekggKTNCSELDKNNLELVNEISNLLGINYENLKDCLVFTEKTIANQKIEIPL 305
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  416 NVQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFV 495
Cdd:cd14937   306 SVEESVSICKSISKDLYNKIFSYITKRINNFLNNNKELNNYIGILDIFGFEIFSKNSLEQLLINIANEEIHSIYLYIVYE 385
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  496 LEQEEYKKEGIEWTFIDFGMDlQACIDLIEKPMGIMSILEEECMFPKATDMTFkAKLFDNHLGKSANFQKPRNIKGKpea 575
Cdd:cd14937   386 KETELYKAEDILIESVKYTTN-ESIIDLLRGKTSIISILEDSCLGPVKNDESI-VSVYTNKFSKHEKYASTKKDINK--- 460
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  576 HFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADApiekgkgkakkGSSFQTVSALHRENL 655
Cdd:cd14937   461 NFVIKHTVSDVTYTITNFISKNKDILPSNIVRLLKVSNNKLVRSLYEDVEVSES-----------LGRKNLITFKYLKNL 529
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  656 NKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRIcRKGFPNRILYGDFRQRYRILNPAAIPEGQF 735
Cdd:cd14937   530 NNIISYLKSTNIYFIKCIKPNENKEKNNFNQKKVFPQLFSLSIIETLNI-SFFFQYKYTFDVFLSYFEYLDYSTSKDSSL 608
                         650       660       670
                  ....*....|....*....|....*....|.
gi 124302198  736 IDSRKGAEKLLSSLDIDhnQYKFGHTKVFFK 766
Cdd:cd14937   609 TDKEKVSMILQNTVDPD--LYKVGKTMVFLK 637
MYSc_Myo17 cd14879
class XVII myosin, motor domain; This fungal myosin which is also known as chitin synthase ...
105-765 7.00e-83

class XVII myosin, motor domain; This fungal myosin which is also known as chitin synthase uses its motor domain to tether its vesicular cargo to peripheral actin. It works in opposition to dynein, contributing to the retention of Mcs1 vesicles at the site of cell growth and increasing vesicle fusion necessary for polarized growth. Class 17 myosins consist of a N-terminal myosin motor domain with Cyt-b5, chitin synthase 2, and a DEK_C domains at it C-terminus. The chitin synthase region contains several transmembrane domains by which myosin 17 is thought to bind secretory vesicles. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276845 [Multi-domain]  Cd Length: 647  Bit Score: 287.14  E-value: 7.00e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  105 LKDRYGSWMIYTY---SGLfcVTVNPYKWLPVYTPEVVAAYR-------GKKRSEAPPHIFSISDNAYQYMLTDRENQSI 174
Cdd:cd14879    10 LASRFRSDLPYTRlgsSAL--VAVNPYKYLSSNSDASLGEYGseyydttSGSKEPLPPHAYDLAARAYLRMRRRSEDQAV 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  175 LITGESGAGKTVNTKRVIQyfaviaAIGDRSKkdqSPGKGT-LEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFG 253
Cdd:cd14879    88 VFLGETGSGKSESRRLLLR------QLLRLSS---HSKKGTkLSSQISAAEFVLDSFGNAKTLTNPNASRFGRYTELQFN 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  254 ATGKLASADIETYLLEKSRVIfQLKA-ERDYHIFYQILSNKKPELLDMLLItNNPYDYAFI--SQGETTVAS--IDDAEE 328
Cdd:cd14879   159 ERGRLIGAKVLDYRLERSRVA-SVPTgERNFHVFYYLLAGASPEERQHLGL-DDPSDYALLasYGCHPLPLGpgSDDAEG 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  329 LMATDNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFklkqreeQAEPDGTEEA---------DKSAYLMGLNSADLLKGL 399
Cdd:cd14879   237 FQELKTALKTLGFKRKHVAQICQLLAAILHLGNLEF-------TYDHEGGEESavvkntdvlDIVAAFLGVSPEDLETSL 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  400 CHPRVKVGNEYVTkgqnvqqvIY--ATGA------LAKAVYERMFNWMVTRINATL-ETKQPRQYFIGVLDIAGFEIFD- 469
Cdd:cd14879   310 TYKTKLVRKELCT--------VFldPEGAaaqrdeLARTLYSLLFAWVVETINQKLcAPEDDFATFISLLDFPGFQNRSs 381
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  470 --FNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFgMDLQACIDLI-EKPMGIMSILEEEC-MFPKATD 545
Cdd:cd14879   382 tgGNSLDQFCVNFANERLHNYVLRSFFERKAEELEAEGVSVPATSY-FDNSDCVRLLrGKPGGLLGILDDQTrRMPKKTD 460
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  546 MTFKAKLfDNHLGKSANFQKPRNIKGKPEAH-FSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLyqksslkLLSTLFANY 624
Cdd:cd14879   461 EQMLEAL-RKRFGNHSSFIAVGNFATRSGSAsFTVNHYAGEVTYSVEGFLERNGDVLSPDFVNL-------LRGATQLNA 532
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  625 AgadapiekgkgkakkgssfqtvsalhrenLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRI 704
Cdd:cd14879   533 A-----------------------------LSELLDTLDRTRLWSVFCIRPNDSQLPNSFDKRRVKAQIRSLGLPELAAR 583
                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 124302198  705 CRKGFPNRILYGDFRQRYrilnpaaIPEGQFIDSRKGAEKLLSSLDIDHNQYKFGHTKVFF 765
Cdd:cd14879   584 LRVEYVVSLEHAEFCERY-------KSTLRGSAAERIRQCARANGWWEGRDYVLGNTKVFL 637
MYSc_Myo23 cd14884
class XXIII myosin, motor domain; These myosins are predicted to have a neck region with 1-2 ...
99-714 1.58e-74

class XXIII myosin, motor domain; These myosins are predicted to have a neck region with 1-2 IQ motifs and a single MyTH4 domain in its C-terminal tail. The lack of a FERM domain here is odd since MyTH4 domains are usually found alongside FERM domains where they bind to microtubules. At any rate these Class XXIII myosins are still proposed to function in the apicomplexan microtubule cytoskeleton. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276850 [Multi-domain]  Cd Length: 685  Bit Score: 263.69  E-value: 1.58e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLP-VYTPEVVAAYRGKKRSEA-------PPHIFSISDNAYQYMLTDRE 170
Cdd:cd14884     1 PNVLQNLKNRYLKNKIYTFHASLLLALNPYKPLKeLYDQDVMNVYLHKKSNSAasaapfpKAHIYDIANMAYKNMRGKLK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  171 NQSILITGESGAGKTVNTKRVIQYFAVIAaiGDRSKKDqspgkgtLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRI 250
Cdd:cd14884    81 RQTIVVSGHSGSGKTENCKFLFKYFHYIQ--TDSQMTE-------RIDKLIYINNILESMSNATTIKNNNSSRCGRINLL 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  251 HF---------GATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGE---- 317
Cdd:cd14884   152 IFeeventqknMFNGCFRNIKIKILLLEINRCIAHNFGERNFHVFYQVLRGLSDEDLARRNLVRNCGVYGLLNPDEshqk 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  318 --------TTVASIDDAEELMATD--------NAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLkqreeqaepdgteea 381
Cdd:cd14884   232 rsvkgtlrLGSDSLDPSEEEKAKDeknfvallHGLHYIKYDERQINEFFDIIAGILHLGNRAYKA--------------- 296
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  382 dkSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINAT----------LETKQ 451
Cdd:cd14884   297 --AAECLQIEEEDLENVIKYKNIRVSHEVIRTERRKENATSTRDTLIKFIYKKLFNKIIEDINRNvlkckekdesDNEDI 374
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  452 PR--QYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDF--GMDLQACIDLIEKP 527
Cdd:cd14884   375 YSinEAIISILDIYGFEELSGNDFDQLCINLANEKLNNYYINNEIEKEKRIYARENIICCSDVApsYSDTLIFIAKIFRR 454
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  528 MGIMSILEEECMfpKATDMTFKAKLFDN----HLGK--SANFQKPRNIKGKPEAH------FSLIHYAGIVDYNIIGWLQ 595
Cdd:cd14884   455 LDDITKLKNQGQ--KKTDDHFFRYLLNNerqqQLEGkvSYGFVLNHDADGTAKKQnikkniFFIRHYAGLVTYRINNWID 532
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  596 KNKDPLNETVVGLYQKSSLKLLStlfanyagadapiekGKGKAKKGSSFQTVSALHRENLNKLMTNLRSTHPHFVRCIIP 675
Cdd:cd14884   533 KNSDKIETSIETLISCSSNRFLR---------------EANNGGNKGNFLSVSKKYIKELDNLFTQLQSTDMYYIRCFLP 597
                         650       660       670
                  ....*....|....*....|....*....|....*....
gi 124302198  676 NETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRIL 714
Cdd:cd14884   598 NAKMLPNTFKRLLVYRQLKQCGSNEMIKILNRGLSHKIP 636
MYSc_Myo12 cd14874
class XXXIII myosin, motor domain; Little is known about the XXXIII class of myosins. They ...
100-766 1.91e-70

class XXXIII myosin, motor domain; Little is known about the XXXIII class of myosins. They are found predominately in nematodes. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276841 [Multi-domain]  Cd Length: 628  Bit Score: 250.17  E-value: 1.91e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  100 AVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYrgkkrseappHIFSISDNAYQYMLTDREN-QSILITG 178
Cdd:cd14874     2 GIAQNLHERFKKGQTYTKASNVLVFVNDFNKLSIQDQLVIKKC----------HISGVAENALDRIKSMSSNaESIVFGG 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  179 ESGAGKTVNTKRVIQYFAviaaigdrskkdQSPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKL 258
Cdd:cd14874    72 ESGSGKSYNAFQVFKYLT------------SQPKSKVTTKHSSAIESVFKSFGCAKTLKNDEATRFGCSIDLLYKRNVLT 139
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  259 ASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNpYDYAFISQGETTVASIDDAEELMATDNAFDV 338
Cdd:cd14874   140 GLNLKYTVPLEVPRVISQKPGERNFNVFYEVYHGLNDEMKAKFGIKGL-QKFFYINQGNSTENIQSDVNHFKHLEDALHV 218
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  339 LGFTSEEKNSMYKLTGAIMHFGNMKFKLKQ----REEQAEPDGTEEADKSAYLMGLNSADLLKGLChPRVKVGNEYvtkg 414
Cdd:cd14874   219 LGFSDDHCISIYKIISTILHIGNIYFRTKRnpnvEQDVVEIGNMSEVKWVAFLLEVDFDQLVNFLL-PKSEDGTTI---- 293
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  415 qNVQQVIYATGALAKAVYERMFNWMVTRINatLETKQPRQY-FIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHM 493
Cdd:cd14874   294 -DLNAALDNRDSFAMLIYEELFKWVLNRIG--LHLKCPLHTgVISILDHYGFEKYNNNGVEEFLINSVNERIENLFVKHS 370
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  494 FVLEQEEYKKEGIEwtfIDFGMdlQACID-------LIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSAnFQKP 566
Cdd:cd14874   371 FHDQLVDYAKDGIS---VDYKV--PNSIEngktvelLFKKPYGLLPLLTDECKFPKGSHESYLEHCNLNHTDRSS-YGKA 444
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  567 RNikgKPEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADAPIEKGKGKAKKGSSFQT 646
Cdd:cd14874   445 RN---KERLEFGVRHCIGTTWYNVTDFFSRNKRIISLSAVQLLRSSKNPIIGLLFESYSSNTSDMIVSQAQFILRGAQEI 521
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  647 VsalhrENLNKlmtnlrsTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILN 726
Cdd:cd14874   522 A-----DKING-------SHAHFVRCIKSNNERQPKKFDIPLVNRQIKNLLLAELLSFRIKGYPVKISKTTFARQYRCLL 589
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|.
gi 124302198  727 PAAIPEGQfiDSRKGAEKLLSSLDIDH-NQYKFGHTKVFFK 766
Cdd:cd14874   590 PGDIAMCQ--NEKEIIQDILQGQGVKYeNDFKIGTEYVFLR 628
MYSc_Myo20 cd14881
class XX myosin, motor domain; These class 20 myosins are primarily insect myosins with such ...
100-746 7.22e-70

class XX myosin, motor domain; These class 20 myosins are primarily insect myosins with such members as Drosophila, Daphnia, and mosquitoes. These myosins contain a single IQ motif in the neck region. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276847 [Multi-domain]  Cd Length: 633  Bit Score: 248.49  E-value: 7.22e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  100 AVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPvyTPEVVAAYRGKKRSeapPHIFSISDNAYQYMLTDRENQSILITGE 179
Cdd:cd14881     2 AVMKCLQARFYAKEFFTNVGPILLSVNPYRDVG--NPLTLTSTRSSPLA---PQLLKVVQEAVRQQSETGYPQAIILSGT 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  180 SGAGKTVNTKRVI-QYFAVIaaigdrskkdqspGKGTLED---QIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFgAT 255
Cdd:cd14881    77 SGSGKTYASMLLLrQLFDVA-------------GGGPETDafkHLAAAFTVLRSLGSAKTATNSESSRIGHFIEVQV-TD 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  256 GKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITN-NPYDYAFISQGETTVASIDDAEELMATDN 334
Cdd:cd14881   143 GALYRTKIHCYFLDQTRVIRPLPGEKNYHIFYQMLAGLSQEERVKLHLDGySPANLRYLSHGDTRQNEAEDAARFQAWKA 222
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  335 AFDVLG--FTSeeknsMYKLTGAIMHFGNMKFkLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGL---CHprvkvgne 409
Cdd:cd14881   223 CLGILGipFLD-----VVRVLAAVLLLGNVQF-IDGGGLEVDVKGETELKSVAALLGVSGAALFRGLttrTH-------- 288
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  410 yVTKGQNVQQVIYAT------GALAKAVYERMFNWMVTRIN------ATLETKQpRQYFIGVLDIAGFEIFDFNSFEQLC 477
Cdd:cd14881   289 -NARGQLVKSVCDANmsnmtrDALAKALYCRTVATIVRRANslkrlgSTLGTHA-TDGFIGILDMFGFEDPKPSQLEHLC 366
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  478 INFTNEKLQQFFNHHMFVLEQEEYKKEGIewtfidfGMDLQA-------CIDLIEK-PMGIMSILEEECMfPKATDMTFK 549
Cdd:cd14881   367 INLCAETMQHFYNTHIFKSSIESCRDEGI-------QCEVEVdyvdnvpCIDLISSlRTGLLSMLDVECS-PRGTAESYV 438
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  550 AKLfdnhlgKSANFQKPRNIKGKPEA--HFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLkllSTLFANYAga 627
Cdd:cd14881   439 AKI------KVQHRQNPRLFEAKPQDdrMFGIRHFAGRVVYDASDFLDTNRDVVPDDLVAVFYKQNC---NFGFATHT-- 507
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  628 dapiekgkgkakkgSSFQTvsalhreNLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRK 707
Cdd:cd14881   508 --------------QDFHT-------RLDNLLRTLVHARPHFVRCIRSNTTETPNHFDRGTVVRQIRSLQVLETVNLMAG 566
                         650       660       670
                  ....*....|....*....|....*....|....*....
gi 124302198  708 GFPNRILYGDFRQRYRILNPAAiPEGQFIDSRKGAEKLL 746
Cdd:cd14881   567 GYPHRMRFKAFNARYRLLAPFR-LLRRVEEKALEDCALI 604
MYSc_Myo44 cd14905
class XLIV myosin, motor domain; There is little known about the function of the myosin XLIV ...
105-718 1.40e-65

class XLIV myosin, motor domain; There is little known about the function of the myosin XLIV class. Members here include cellular slime mold Polysphondylium and soil-living amoeba Dictyostelium. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276870  Cd Length: 673  Bit Score: 236.91  E-value: 1.40e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  105 LKDRYGSWMIYTYSGLFCVTVNPYKWLP-VYTPEVVAAYrgKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAG 183
Cdd:cd14905     7 IQARYKKEIIYTYIGPILVSVNPLRYLPfLHSQELVRNY--NQRRGLPPHLFALAAKAISDMQDFRRDQLIFIGGESGSG 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  184 KTVNTKRVIQYfaVIAAIGDRSKkdqspgkgTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADI 263
Cdd:cd14905    85 KSENTKIIIQY--LLTTDLSRSK--------YLRDYILESGIILESFGHASTDSNHNSSRWGKYFEMFYSLYGEIQGAKL 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  264 ETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITN-NPYDYafISQGET-TVASIDDAEELMATDNAFDVLGF 341
Cdd:cd14905   155 YSYFLDENRVTYQNKGERNFHIFYQFLKGITDEEKAAYQLGDiNSYHY--LNQGGSiSVESIDDNRVFDRLKMSFVFFDF 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  342 TSEEKNSMYKLTGAIMHFGNMKFKLKQREeqaepdgTEEADKSaylmglnsadLLKGLCH----PRVKVGNEYVT-KGQN 416
Cdd:cd14905   233 PSEKIDLIFKTLSFIIILGNVTFFQKNGK-------TEVKDRT----------LIESLSHnitfDSTKLENILISdRSMP 295
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  417 VQQVIYATGALAKAVYERMFNWMVTRINATLetkQPRQY--FIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMF 494
Cdd:cd14905   296 VNEAVENRDSLARSLYSALFHWIIDFLNSKL---KPTQYshTLGILDLFGQESSQLNGYEQFSINFLEERLQQIYLQTVL 372
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  495 VLEQEEYKKEGIEW-TFIDFgMDLQACIDLIEKpmgIMSILEEECMFPKATDMTFKAKLfdnhlgksANFQKPRNIKGKP 573
Cdd:cd14905   373 KQEQREYQTERIPWmTPISF-KDNEESVEMMEK---IINLLDQESKNINSSDQIFLEKL--------QNFLSRHHLFGKK 440
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  574 EAHFSLIHYAGIVDYNIIGWLQKNKDP-------------------------LNETVVGLYQ---------KSSLKLLST 619
Cdd:cd14905   441 PNKFGIEHYFGQFYYDVRGFIIKNRDEilqrtnvlhknsitkylfsrdgvfnINATVAELNQmfdakntakKSPLSIVKV 520
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  620 LFA--------------NYAGADAPIEKGKGKAKKGSSFQTVSAlhrenLNKLMTNlRSTHPHFVRCIIPNETKSPGVMD 685
Cdd:cd14905   521 LLScgsnnpnnvnnpnnNSGGGGGGGNSGGGSGSGGSTYTTYSS-----TNKAINN-SNCDFHFIRCIKPNSKKTHLTFD 594
                         650       660       670
                  ....*....|....*....|....*....|....*..
gi 124302198  686 NPLVMHQLRCNGVLEGIRICRKGFP----NRILYGDF 718
Cdd:cd14905   595 VKSVNEQIKSLCLLETTRIQRFGYTihynNKIFFDRF 631
MYSc_Myo32 cd14893
class XXXII myosin, motor domain; Class XXXII myosins do not contain any IQ motifs, but ...
102-765 1.59e-65

class XXXII myosin, motor domain; Class XXXII myosins do not contain any IQ motifs, but possess tandem MyTH4 and FERM domains. The myosin classes XXX to XXXIV contain members from Phytophthora species and Hyaloperonospora parasitica. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276858  Cd Length: 741  Bit Score: 238.33  E-value: 1.59e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  102 LYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKR----------SEAPPHIFSISDNAYQYMLTDREN 171
Cdd:cd14893     4 LYTLRARYRMEQVYTWVDRVLVGVNPVTPLPIYTPDHMQAYNKSREqtplyekdtvNDAPPHVFALAQNALRCMQDAGED 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  172 QSILITGESGAGKTVNTKRVIQYfavIAAIGDRS--KKDQSPGKGTLE---DQIIQANPALEAFGNAKTVRNDNSSRFGK 246
Cdd:cd14893    84 QAVILLGGMGAGKSEAAKLIVQY---LCEIGDETepRPDSEGASGVLHpigQQILHAFTILEAFGNAATRQNRNSSRFAK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  247 FIRIHFGATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKK--PELLDMLLITNNPYDYAFISQG--ETTVAS 322
Cdd:cd14893   161 MISVEFSKHGHVIGGGFTTHYFEKSRVIDCRSHERNFHVFYQVLAGVQhdPTLRDSLEMNKCVNEFVMLKQAdpLATNFA 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  323 ID--DAEELMATdnaFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAYLMGLN-------SA 393
Cdd:cd14893   241 LDarDYRDLMSS---FSALRIRKNQRVEIVRIVAALLHLGNVDFVPDPEGGKSVGGANSTTVSDAQSCALKdpaqillAA 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  394 DLLKglCHPRV------------KVGNEYVT--KGQNVQQVIYATGALAKAVYERMFNWMVTRINATLETKQPR------ 453
Cdd:cd14893   318 KLLE--VEPVVldnyfrtrqffsKDGNKTVSslKVVTVHQARKARDTFVRSLYESLFNFLVETLNGILGGIFDRyeksni 395
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  454 ---QYFIGVLDIAGFEIFD--FNSFEQLCINFTNEKLQQFFNHHMFV-----LEQEEYKKEG--IEWTFIDFGMDLQACI 521
Cdd:cd14893   396 vinSQGVHVLDMVGFENLTpsQNSFDQLCFNYWSEKVHHFYVQNTLAinfsfLEDESQQVENrlTVNSNVDITSEQEKCL 475
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  522 DLIE-KPMGIMSILEEECMFPKATDMTFKAKLFDNH-----LGKSANFQKPRNIKGKPEAHFSLI----HYAGIVDYNII 591
Cdd:cd14893   476 QLFEdKPFGIFDLLTENCKVRLPNDEDFVNKLFSGNeavggLSRPNMGADTTNEYLAPSKDWRLLfivqHHCGKVTYNGK 555
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  592 GWLQKNKDPLNETVVGLYQKSSLKLLSTLFANY---AGADAPIEKGKGKAKKGSSFQTVSALHRENLN------------ 656
Cdd:cd14893   556 GLSSKNMLSISSTCAAIMQSSKNAVLHAVGAAQmaaASSEKAAKQTEERGSTSSKFRKSASSARESKNitdsaatdvynq 635
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  657 --KLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRilnpaaipegQ 734
Cdd:cd14893   636 adALLHALNHTGKNFLVCIKPNETLEEGVFDSAYVMKQIRMNHLVELMQASRSIFTVHLTYGHFFRRYK----------N 705
                         730       740       750
                  ....*....|....*....|....*....|....*
gi 124302198  735 FIDSRKGAEKLLSSLD----IDHNQYKFGHTKVFF 765
Cdd:cd14893   706 VCGHRGTLESLLRSLSaigvLEEEKFVVGKTKVYL 740
Motor_domain cd01363
Myosin and Kinesin motor domain; Myosin and Kinesin motor domain. These ATPases belong to the ...
121-250 4.02e-62

Myosin and Kinesin motor domain; Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes. Some of the names do not match with what is given in the sequence list. This is because they are based on the current nomenclature by Kollmar/Sebe-Pedros.


Pssm-ID: 276814 [Multi-domain]  Cd Length: 170  Bit Score: 209.89  E-value: 4.02e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  121 FCVTVNPYKWLPVYTPEVV-AAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFAVIA 199
Cdd:cd01363     1 VLVRVNPFKELPIYRDSKIiVFYRGFRRSESQPHVFAIADPAYQSMLDGYNNQSIFAYGESGAGKTETMKGVIPYLASVA 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 124302198  200 AIGDRSKKDQ-----SPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRI 250
Cdd:cd01363    81 FNGINKGETEgwvylTEITVTLEDQILQANPILEAFGNAKTTRNENSSRFGKFIEI 136
MYSc_Myo21 cd14882
class XXI myosin, motor domain; The myosins here are comprised of insects. Leishmania class ...
101-725 2.08e-61

class XXI myosin, motor domain; The myosins here are comprised of insects. Leishmania class XXI myosins do not group with them. Myo21, unlike other myosin proteins, contains UBA-like protein domains and has no structural or functional relationship with the myosins present in other organisms possessing cilia or flagella. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. They have diverse tails with IQ, WW, PX, and Tub domains. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276848  Cd Length: 642  Bit Score: 223.85  E-value: 2.08e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  101 VLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGES 180
Cdd:cd14882     3 ILEELRHRYLMGESYTFIGDILLSLNPNEIKQEYPQEFHAKYRCKSRSDNAPHIFSVADSAYQDMLHHEEPQHIILSGES 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  181 GAGKTVNTKRVIQYFAViaaIGDrskkdqspGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLAS 260
Cdd:cd14882    83 YSGKTTNARLLIKHLCY---LGD--------GNRGATGRVESSIKAILALVNAGTPLNADSTRCILQYQLTFGSTGKMSG 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  261 ADIETYLLEKSRVIFQLKAERDYHIFYQILS--NKKPELLDMLLITNNPYDYAFISQG-------------ETTVASIDD 325
Cdd:cd14882   152 AIFWMYQLEKLRVSTTDGNQSNFHIFYYFYDfiEAQNRLKEYNLKAGRNYRYLRIPPEvppsklkyrrddpEGNVERYKE 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  326 AEELmatdnaFDVLGFTSEEKNSMYKLTGAIMHFGNMKFklKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVK 405
Cdd:cd14882   232 FEEI------LKDLDFNEEQLETVRKVLAAILNLGEIRF--RQNGGYAELENTEIASRVAELLRLDEKKFMWALTNYCLI 303
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  406 VGNEYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATLETkqPR-----QYFIGVLDIAGFEIFDFNSFEQLCINF 480
Cdd:cd14882   304 KGGSAERRKHTTEEARDARDVLASTLYSRLVDWIINRINMKMSF--PRavfgdKYSISIHDMFGFECFHRNRLEQLMVNT 381
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  481 TNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEecmfpKATDMTFKAKLFDNHLGKS 560
Cdd:cd14882   382 LNEQMQYHYNQRIFISEMLEMEEEDIPTINLRFYDNKTAVDQLMTKPDGLFYIIDD-----ASRSCQDQNYIMDRIKEKH 456
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  561 ANFQKPRNikgkpeAH-FSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANyagadapiekgkgkaK 639
Cdd:cd14882   457 SQFVKKHS------AHeFSVAHYTGRIIYDAREFADKNRDFVPPEMIETMRSSLDESVKLMFTN---------------S 515
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  640 KGSSFQTVSALHR----ENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILY 715
Cdd:cd14882   516 QVRNMRTLAATFRatslELLKMLSIGANSGGTHFVRCIRSDLEYKPRGFHSEVVRQQMRALAVLDTAKARQKGFSYRIPF 595
                         650
                  ....*....|
gi 124302198  716 GDFRQRYRIL 725
Cdd:cd14882   596 QEFLRRYQFL 605
MYSc_Myo24B cd14938
class XXIV B myosin, motor domain; These myosins have a 1-2 IQ motifs in their neck and a ...
99-764 2.17e-44

class XXIV B myosin, motor domain; These myosins have a 1-2 IQ motifs in their neck and a coiled-coil region in their C-terminal tail. The functions of these myosins remain elusive. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276898 [Multi-domain]  Cd Length: 713  Bit Score: 173.87  E-value: 2.17e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   99 PAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSE-APPHIFSISDNAYQYMLTDRENQSILIT 177
Cdd:cd14938     1 PSVLYHLKERFKNNKFYTKMGPLLIFINPKINNNINNEETIEKYKCIDCIEdLSLNEYHVVHNALKNLNELKRNQSIIIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  178 GESGAGKTVNTKRVIQYFAViAAIGDRSKKDQS--------------PGKGTLEDQIIQANPALEAFGNAKTVRNDNSSR 243
Cdd:cd14938    81 GESGSGKSEIAKNIINFIAY-QVKGSRRLPTNLndqeednihneentDYQFNMSEMLKHVNVVMEAFGNAKTVKNNNSSR 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  244 FGKFIRIHFgATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYdYAFISQGETTVASI 323
Cdd:cd14938   160 FSKFCTIHI-ENEEIKSFHIKKFLLDKERLINRKANENSFNIFYYIINGSSDKFKKMYFLKNIEN-YSMLNNEKGFEKFS 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  324 DDAEELMATDNAFDVLGFTSEEKNSMYKLTGAIMHFGN-------------MKFKLKQRE----------EQAEPDGTEE 380
Cdd:cd14938   238 DYSGKILELLKSLNYIFDDDKEIDFIFSVLSALLLLGNteivkafrkksllMGKNQCGQNinyetilselENSEDIGLDE 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  381 ADKSAYL----MGLNSADLLKGLCHPRVkVGNEYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYF 456
Cdd:cd14938   318 NVKNLLLacklLSFDIETFVKYFTTNYI-FNDSILIKVHNETKIQKKLENFIKTCYEELFNWIIYKINEKCTQLQNININ 396
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  457 ---IGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLQACIDLIEKPM--GIM 531
Cdd:cd14938   397 tnyINVLDMAYFENSKDNSLEQLLINTTNEEIIKIKNDCLYKKRVLSYNEDGIFCEYNSENIDNEPLYNLLVGPTegSLF 476
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  532 SILEEECMfPKATDMTFKAKLFDNHLGKSANFQKPRNIKGKPEAhFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQK 611
Cdd:cd14938   477 SLLENVST-KTIFDKSNLHSSIIRKFSRNSKYIKKDDITGNKKT-FVITHSCGDIIYNAENFVEKNIDILTNRFIDMVKQ 554
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  612 SSLKLLSTL--FANYAGADAPIEKGKG----------KAKKGSSFQTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETK 679
Cdd:cd14938   555 SENEYMRQFcmFYNYDNSGNIVEEKRRysiqsalklfKRRYDTKNQMAVSLLRNNLTELEKLQETTFCHFIVCMKPNESK 634
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  680 SP-GVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPaaipegqfiDSRKGAEKLLSSLDIDHNQYKF 758
Cdd:cd14938   635 RElCSFDANIVLRQVRNFSIVEASQLKVGYYPHKFTLNEFLSIFDIKNE---------DLKEKVEALIKSYQISNYEWMI 705

                  ....*.
gi 124302198  759 GHTKVF 764
Cdd:cd14938   706 GNNMIF 711
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
1173-1930 9.63e-33

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 139.42  E-value: 9.63e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1173 KMRRdlEEATLQHEATAAALrKKHADSVAELGEQIDNLQRVKQK----LEKEKSEFKLELDDVTSNMEQIIKAKANLEKM 1248
Cdd:TIGR02168  171 KERR--KETERKLERTRENL-DRLEDILNELERQLKSLERQAEKaeryKELKAELRELELALLVLRLEELREELEELQEE 247
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1249 CRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEevkAKNA 1328
Cdd:TIGR02168  248 LKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEE---LEAQ 324
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1329 LAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRtkyetDAIQRTEELEEAKKKLAQRLQEAEEAVEAVN 1408
Cdd:TIGR02168  325 LEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELE-----ELESRLEELEEQLETLRSKVAQLELQIASLN 399
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1409 AKCSSLEKTKHRLQNEIEDLMVDVE--RSNAAAAALDKKQRNF---DKILAEWKQKYEESQSELESSQKEARSLSTELFK 1483
Cdd:TIGR02168  400 NEIERLEARLERLEDRRERLQQEIEelLKKLEEAELKELQAELeelEEELEELQEELERLEEALEELREELEEAEQALDA 479
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1484 LKN----------AYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEA---EKME------LQSAL 1544
Cdd:TIGR02168  480 AERelaqlqarldSLERLQENLEGFSEGVKALLKNQSGLSGILGVLSELISVDEGYEAAIEAalgGRLQavvvenLNAAK 559
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1545 EEAEASLEHEEGK--------ILRAQLEFN--QIKAEIERKLAEKDEEMEQAKR---------NHLRVVDSLQTSLDAET 1605
Cdd:TIGR02168  560 KAIAFLKQNELGRvtflpldsIKGTEIQGNdrEILKNIEGFLGVAKDLVKFDPKlrkalsyllGGVLVVDDLDNALELAK 639
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1606 RSRNEALRVKKkmEGDL-----------NEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIV 1674
Cdd:TIGR02168  640 KLRPGYRIVTL--DGDLvrpggvitggsAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQL 717
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1675 -------ERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQE 1747
Cdd:TIGR02168  718 rkeleelSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEE 797
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1748 CRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKgGKKQLQKLEARVRELENELE 1827
Cdd:TIGR02168  798 LKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIES-LAAEIEELEELIEELESELE 876
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1828 AEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFR-KVQHELDEA 1906
Cdd:TIGR02168  877 ALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSeEYSLTLEEA 956
                          810       820
                   ....*....|....*....|....
gi 124302198  1907 EERADIAESQVNKLRAKSRDIGTK 1930
Cdd:TIGR02168  957 EALENKIEDDEEEARRRLKRLENK 980
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
840-1672 4.50e-30

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 130.56  E-value: 4.50e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   840 LKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKV 919
Cdd:TIGR02168  218 LKAELRELELALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEI 297
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   920 KEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKAL 999
Cdd:TIGR02168  298 SRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEEL 377
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1000 QEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLEraKRKLEGDLKLTQESIMDLENDKQQLDER 1079
Cdd:TIGR02168  378 EEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELL--KKLEEAELKELQAELEELEEELEELQEE 455
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1080 LKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERT---ARAKVEKLRSDLSRELEEISER------- 1149
Cdd:TIGR02168  456 LERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGfseGVKALLKNQSGLSGILGVLSELisvdegy 535
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1150 ---LEEAGGATSVQIEMNKKREAefqkmrRDLEEATLQHEATAAAL----RKKHADSVAELGEQIDNLQRVKQ---KLEK 1219
Cdd:TIGR02168  536 eaaIEAALGGRLQAVVVENLNAA------KKAIAFLKQNELGRVTFlpldSIKGTEIQGNDREILKNIEGFLGvakDLVK 609
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1220 EKSEFKLEL----------DDVTSNMEQIIKAKANLekMCRTLEDQM-----------NEHRSKAEETQRSVNDLTSQRA 1278
Cdd:TIGR02168  610 FDPKLRKALsyllggvlvvDDLDNALELAKKLRPGY--RIVTLDGDLvrpggvitggsAKTNSSILERRREIEELEEKIE 687
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1279 KLQTENGELSRQLDEKEALISQLtrgkltyTQQLEDLKRQLEEEVKAKNALAHALQSArhdcdllreqyEEETEAKAELQ 1358
Cdd:TIGR02168  688 ELEEKIAELEKALAELRKELEEL-------EEELEQLRKELEELSRQISALRKDLARL-----------EAEVEQLEERI 749
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1359 RVLSKANSEVAQWRTKYEtdaiQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLmvdversNAA 1438
Cdd:TIGR02168  750 AQLSKELTELEAEIEELE----ERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLL-------NEE 818
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1439 AAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGS 1518
Cdd:TIGR02168  819 AANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEE 898
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1519 SGKTIHELEKVRKQLEAEKMELQSALEEAEASLEheegkilRAQLEFNQIKAeierKLAEKDE-EMEQAKRNHLRVVDSL 1597
Cdd:TIGR02168  899 LSEELRELESKRSELRRELEELREKLAQLELRLE-------GLEVRIDNLQE----RLSEEYSlTLEEAEALENKIEDDE 967
                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 124302198  1598 QtsldaETRSRNEALRVKKKMEGDLNEMEIQlshanrmaaEAQKQVKSLQSLLKdtqiQLDDAVRANDDLKENIA 1672
Cdd:TIGR02168  968 E-----EARRRLKRLENKIKELGPVNLAAIE---------EYEELKERYDFLTA----QKEDLTEAKETLEEAIE 1024
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
942-1871 1.29e-28

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 125.94  E-value: 1.29e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   942 KLEDECSELKRDIDDLELTLAKVEkekhatenKVKNLTEEMAGLDeiIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLT 1021
Cdd:TIGR02168  190 RLEDILNELERQLKSLERQAEKAE--------RYKELKAELRELE--LALLVLRLEELREELEELQEELKEAEEELEELT 259
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1022 KAKVKLEQQVDDLEGSLEQekkvrmdLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEdeqalg 1101
Cdd:TIGR02168  260 AELQELEEKLEELRLEVSE-------LEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLE------ 326
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1102 sQLQKKLKELQARIeeleeeleaertarAKVEKLRSDLSRELEEISERLEEAGGatsvQIEMNKKREAEFQKMRRDLEEA 1181
Cdd:TIGR02168  327 -ELESKLDELAEEL--------------AELEEKLEELKEELESLEAELEELEA----ELEELESRLEELEEQLETLRSK 387
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1182 TLQHEATAAALRKKhadsVAELGEQIDNLQRVKQKLEKEKSEFKLELDdvtsnmeqiikakanlekmcrtlEDQMNEHRS 1261
Cdd:TIGR02168  388 VAQLELQIASLNNE----IERLEARLERLEDRRERLQQEIEELLKKLE-----------------------EAELKELQA 440
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1262 KAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVK----AKNALAHALQSAR 1337
Cdd:TIGR02168  441 ELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGfsegVKALLKNQSGLSG 520
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1338 HDcDLLREQYEEETEAKAELQRVLSKANSEVAqwrTKYETDAIQRTEELEEAKK--------------KLAQRLQEAEEA 1403
Cdd:TIGR02168  521 IL-GVLSELISVDEGYEAAIEAALGGRLQAVV---VENLNAAKKAIAFLKQNELgrvtflpldsikgtEIQGNDREILKN 596
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1404 VEAVNAKCSSLEKTKHRLQNEIEDL-----MVD-VERSNAAAAALDKKQRNF----DKILAEWkqkyeesqseleSSQKE 1473
Cdd:TIGR02168  597 IEGFLGVAKDLVKFDPKLRKALSYLlggvlVVDdLDNALELAKKLRPGYRIVtldgDLVRPGG------------VITGG 664
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1474 ARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLgssgktiHELEKVRKQLEAEKMELQSALEEAEASLEH 1553
Cdd:TIGR02168  665 SAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKEL-------EELEEELEQLRKELEELSRQISALRKDLAR 737
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1554 EEGKILRAQLEFNQIKAEIERKLAEKDEEMEQakrnhlrvvdslqtsLDAETRSRNEALRVKKKMEGDLNEMEIQLSHAN 1633
Cdd:TIGR02168  738 LEAEVEQLEERIAQLSKELTELEAEIEELEER---------------LEEAEEELAEAEAEIEELEAQIEQLKEELKALR 802
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1634 RMAAEAQKQvkslqslLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIEtserv 1713
Cdd:TIGR02168  803 EALDELRAE-------LTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEE----- 870
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1714 qlLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQdtsAHLERMKKNMEQTIKDL 1793
Cdd:TIGR02168  871 --LESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLE---LRLEGLEVRIDNLQERL 945
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1794 --QHRLDEAEQIALK-GGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDK 1870
Cdd:TIGR02168  946 seEYSLTLEEAEALEnKIEDDEEEARRRLKRLENKIKELGPVNLAAIEEYEELKERYDFLTAQKEDLTEAKETLEEAIEE 1025

                   .
gi 124302198  1871 L 1871
Cdd:TIGR02168 1026 I 1026
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
833-1452 1.94e-26

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 118.50  E-value: 1.94e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  833 YFKIKPLLKSAERE---KEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLI 909
Cdd:COG1196   215 YRELKEELKELEAElllLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELL 294
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  910 KNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEII 989
Cdd:COG1196   295 AELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAEL 374
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  990 AKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDL 1069
Cdd:COG1196   375 AEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAEL 454
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1070 ENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAK---------VEKLRSDLS 1140
Cdd:COG1196   455 EEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLaglrglagaVAVLIGVEA 534
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1141 RELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKE 1220
Cdd:COG1196   535 AYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADAR 614
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1221 KSEFKLELDDVTSNMEQIIKAKAnlekmcrtledQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQ 1300
Cdd:COG1196   615 YYVLGDTLLGRTLVAARLEAALR-----------RAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEE 683
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1301 LTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAqwrtKYETDAI 1380
Cdd:COG1196   684 LAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEA----LEELPEP 759
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1381 QRTEELEEAKKKLAQRLQE-------AEEAVEAVNAKCSSLEKTKHRLQNEIEDLM-----VDVERSNAAAAALDKKQRN 1448
Cdd:COG1196   760 PDLEELERELERLEREIEAlgpvnllAIEEYEELEERYDFLSEQREDLEEARETLEeaieeIDRETRERFLETFDAVNEN 839

                  ....
gi 124302198 1449 FDKI 1452
Cdd:COG1196   840 FQEL 843
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
963-1851 3.65e-25

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 114.77  E-value: 3.65e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   963 KVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALD--DLQAEEDKVNtLTKAKVKLEQQVDDLEGSLEQ 1040
Cdd:TIGR02168  169 KYKERRKETERKLERTRENLDRLEDILNELERQLKSLERQAEKAERykELKAELRELE-LALLVLRLEELREELEELQEE 247
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1041 EKKvrmdLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDeqalgsqLQKKLKELQARIEELEE 1120
Cdd:TIGR02168  248 LKE----AEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISR-------LEQQKQILRERLANLER 316
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1121 ELEAERTARAKVEKLRSDLSRELEEISERLEEAggatSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKhadsV 1200
Cdd:TIGR02168  317 QLEELEAQLEELESKLDELAEELAELEEKLEEL----KEELESLEAELEELEAELEELESRLEELEEQLETLRSK----V 388
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1201 AELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKmcRTLEDQMNEHRSKAEETQRSVNDLTSQRAKL 1280
Cdd:TIGR02168  389 AQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAEL--KELQAELEELEEELEELQEELERLEEALEEL 466
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1281 QTENGELSRQLDEKEALISQLtRGKLTYTQQLEDLKRQLEEEVKakNALAHALQSARHDcDLLREQYEEETEAKAELQRV 1360
Cdd:TIGR02168  467 REELEEAEQALDAAERELAQL-QARLDSLERLQENLEGFSEGVK--ALLKNQSGLSGIL-GVLSELISVDEGYEAAIEAA 542
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1361 LSKANSEVAqwrTKYETDAIQRTEELEEAKK--------------KLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIE 1426
Cdd:TIGR02168  543 LGGRLQAVV---VENLNAAKKAIAFLKQNELgrvtflpldsikgtEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALS 619
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1427 DL-----MVD-VERSNAAAAALDKKQRNF----DKILAEWkqkyeesqseleSSQKEARSLSTELFKLKNAYEESLEHLE 1496
Cdd:TIGR02168  620 YLlggvlVVDdLDNALELAKKLRPGYRIVtldgDLVRPGG------------VITGGSAKTNSSILERRREIEELEEKIE 687
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1497 TFKRENKNLQEEISDLTEQLgssgktiHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKL 1576
Cdd:TIGR02168  688 ELEEKIAELEKALAELRKEL-------EELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELE 760
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1577 AEKDEEMEQakrnhlrvvdslqtsLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQvkslqslLKDTQIQ 1656
Cdd:TIGR02168  761 AEIEELEER---------------LEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAE-------LTLLNEE 818
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1657 LDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIEtservqlLHSQNTSLINQKKKMDADLSQ 1736
Cdd:TIGR02168  819 AANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEE-------LESELEALLNERASLEEALAL 891
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1737 LQTEVEEAVQECRNAEEKakkaitdaammaeelkkeqdtsahlermkknmeqtIKDLQHRLDEAEQiALKGGKKQLQKLE 1816
Cdd:TIGR02168  892 LRSELEELSEELRELESK-----------------------------------RSELRRELEELRE-KLAQLELRLEGLE 935
                          890       900       910       920
                   ....*....|....*....|....*....|....*....|...
gi 124302198  1817 ARVRELENELEAEQKRNAESVKGM--------RKSERRIKELT 1851
Cdd:TIGR02168  936 VRIDNLQERLSEEYSLTLEEAEALenkieddeEEARRRLKRLE 978
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
840-1700 7.50e-25

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 113.62  E-value: 7.50e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   840 LKSAEREKEMAsmkEEFTRLKEalEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKV 919
Cdd:TIGR02169  200 LERLRREREKA---ERYQALLK--EKREYEGYELLKEKEALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLL 274
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   920 KEMNERLEDE-EEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKA 998
Cdd:TIGR02169  275 EELNKKIKDLgEEEQLRVKEKIGELEAEIASLERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDK 354
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   999 LQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDkqqlde 1078
Cdd:TIGR02169  355 LTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREINELKRELDRLQEELQRLSEELADLNAA------ 428
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1079 rLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERL----EEAG 1154
Cdd:TIGR02169  429 -IAGIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQAraseERVR 507
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1155 GATSVQIEMNKKREAEFQKMRrDLEEATLQHEA---TAAALRKKHA----DSVAElgEQIDNLQRVKQ------KLEKEK 1221
Cdd:TIGR02169  508 GGRAVEEVLKASIQGVHGTVA-QLGSVGERYATaieVAAGNRLNNVvvedDAVAK--EAIELLKRRKAgratflPLNKMR 584
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1222 SEfklELDDVTSNMEQIIKAKANLekmcRTLEDQMNEHRSKAEETQRSVNDLTSQRA-----KLQTENGELSrqldEKEA 1296
Cdd:TIGR02169  585 DE---RRDLSILSEDGVIGFAVDL----VEFDPKYEPAFKYVFGDTLVVEDIEAARRlmgkyRMVTLEGELF----EKSG 653
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1297 LIS----QLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRvLSKANSEVAQwr 1372
Cdd:TIGR02169  654 AMTggsrAPRGGILFSRSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGE-IEKEIEQLEQ-- 730
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1373 tkYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNaaaaaLDKKQRNFDKI 1452
Cdd:TIGR02169  731 --EEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARLSHSR-----IPEIQAELSKL 803
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1453 laewkqkyeesqselessQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQ 1532
Cdd:TIGR02169  804 ------------------EEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEE 865
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1533 LEAEKMELQSALEEAEASLEHEEGKILRAQLEfnqiKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEAL 1612
Cdd:TIGR02169  866 LEEELEELEAALRDLESRLGDLKKERDELEAQ----LRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKG 941
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1613 RVKKKMEGDLNEMEIQLshanrMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKEniaiverRNNLLQAELEELRAVV 1692
Cdd:TIGR02169  942 EDEEIPEEELSLEDVQA-----ELQRVEEEIRALEPVNMLAIQEYEEVLKRLDELKE-------KRAKLEEERKAILERI 1009

                   ....*...
gi 124302198  1693 EQTERSRK 1700
Cdd:TIGR02169 1010 EEYEKKKR 1017
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
1310-1928 4.86e-24

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 110.80  E-value: 4.86e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1310 QQLEDLKRQ-----------LEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVaqwrtkyetd 1378
Cdd:COG1196   200 RQLEPLERQaekaeryrelkEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAEL---------- 269
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1379 aiqrtEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQ 1458
Cdd:COG1196   270 -----EELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEE 344
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1459 KYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKM 1538
Cdd:COG1196   345 ELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELE 424
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1539 ELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRsrneaLRVKKKM 1618
Cdd:COG1196   425 ELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAAR-----LLLLLEA 499
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1619 EGDlnemeiqlshanrmAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQaeleelRAVVEQTERS 1698
Cdd:COG1196   500 EAD--------------YEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQ------NIVVEDDEVA 559
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1699 RKLAEQELIETSERVQLLHSqntSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAH 1778
Cdd:COG1196   560 AAAIEYLKAAKAGRATFLPL---DKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAAL 636
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1779 LERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVkgmRKSERRIKELTYQTEEDR 1858
Cdd:COG1196   637 RRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELEL---EEALLAEEEEERELAEAE 713
                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1859 KNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSkfrKVQHELDEAEERADIAESQVNKLRAKSRDIG 1928
Cdd:COG1196   714 EERLEEELEEEALEEQLEAEREELLEELLEEEELLE---EEALEELPEPPDLEELERELERLEREIEALG 780
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
1106-1909 3.28e-23

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 108.23  E-value: 3.28e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1106 KKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEaggatsVQIEMNKKReaEFQKMRRDLEEAtlqh 1185
Cdd:TIGR02169  156 RKIIDEIAGVAEFDRKKEKALEELEEVEENIERLDLIIDEKRQQLER------LRREREKAE--RYQALLKEKREY---- 223
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1186 EATAAALRKKHADsvaelgEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTL-EDQMNEHRSKAE 1264
Cdd:TIGR02169  224 EGYELLKEKEALE------RQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLgEEEQLRVKEKIG 297
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1265 ETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRgkltytqQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLR 1344
Cdd:TIGR02169  298 ELEAEIASLERSIAEKERELEDAEERLAKLEAEIDKLLA-------EIEELEREIEEERKRRDKLTEEYAELKEELEDLR 370
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1345 EQYEEETEAKAELQRvlskansEVAQWRTKYEtDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNE 1424
Cdd:TIGR02169  371 AELEEVDKEFAETRD-------ELKDYREKLE-KLKREINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEE 442
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1425 IEDLMVDVErsnaaaaALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLknayEESLEHLETFKRENKN 1504
Cdd:TIGR02169  443 KEDKALEIK-------KQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEA----EAQARASEERVRGGRA 511
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1505 LQEEISDLTEqlGSSGkTIHELEKVRKQ------------LEAEKMELQSALEEAEASLEHEegKILRAQ-LEFNQIKAE 1571
Cdd:TIGR02169  512 VEEVLKASIQ--GVHG-TVAQLGSVGERyataievaagnrLNNVVVEDDAVAKEAIELLKRR--KAGRATfLPLNKMRDE 586
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1572 --------------IERKLAEKDEEMEQAKRNHLR---VVDSLQT-----------SLDAE-----------TRSRNEAL 1612
Cdd:TIGR02169  587 rrdlsilsedgvigFAVDLVEFDPKYEPAFKYVFGdtlVVEDIEAarrlmgkyrmvTLEGElfeksgamtggSRAPRGGI 666
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1613 RVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVV 1692
Cdd:TIGR02169  667 LFSRSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDL 746
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1693 EQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSqlQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKE 1772
Cdd:TIGR02169  747 SSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARLS--HSRIPEIQAELSKLEEEVSRIEARLREIEQKLNRL 824
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1773 QDTSAHLERMKKNMEQTIKDLQHRLDE-AEQIALKGGKK-----QLQKLEARVRELENELEAEQKRNAESVKGMRKSERR 1846
Cdd:TIGR02169  825 TLEKEYLEKEIQELQEQRIDLKEQIKSiEKEIENLNGKKeeleeELEELEAALRDLESRLGDLKKERDELEAQLRELERK 904
                          810       820       830       840       850       860
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 124302198  1847 IKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSkFRKVQHELDEAEER 1909
Cdd:TIGR02169  905 IEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDEEIPEEELS-LEDVQAELQRVEEE 966
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
1074-1729 5.91e-23

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 107.33  E-value: 5.91e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1074 QQLDERLKKKD-----FELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISE 1148
Cdd:COG1196   216 RELKEELKELEaelllLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLA 295
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1149 RLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALrkkhadsvAELGEQIDNLQRVKQKLEKEKSEFKLEL 1228
Cdd:COG1196   296 ELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEEL--------EELEEELEEAEEELEEAEAELAEAEEAL 367
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1229 DDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTrgklty 1308
Cdd:COG1196   368 LEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEE------ 441
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1309 tQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEE 1388
Cdd:COG1196   442 -EALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLR 520
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1389 AKKKLAQRLQEAEEAVEAVnakcsslektkhrLQNEIEDLMVDVERSNAAAAAldkKQRNFDKILAEWKQKYEESQSELE 1468
Cdd:COG1196   521 GLAGAVAVLIGVEAAYEAA-------------LEAALAAALQNIVVEDDEVAA---AAIEYLKAAKAGRATFLPLDKIRA 584
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1469 SSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAE 1548
Cdd:COG1196   585 RAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTG 664
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1549 ASLEHEEGKILRAQlefnqikAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQ 1628
Cdd:COG1196   665 GSRRELLAALLEAE-------AELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREEL 737
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1629 LShanrmaaeaqkqvkslqsLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEqtersrkLAEQELIE 1708
Cdd:COG1196   738 LE------------------ELLEEEELLEEEALEELPEPPDLEELERELERLEREIEALGPVNL-------LAIEEYEE 792
                         650       660
                  ....*....|....*....|.
gi 124302198 1709 TSERVQLLHSQNTSLINQKKK 1729
Cdd:COG1196   793 LEERYDFLSEQREDLEEARET 813
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
844-1578 2.48e-22

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 105.15  E-value: 2.48e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   844 EREKEMAsmKEEFTRLKEALEKSEARRKELEEKMVSLLQEKND--------------------------------LQLQV 891
Cdd:TIGR02169  169 DRKKEKA--LEELEEVEENIERLDLIIDEKRQQLERLRREREKaeryqallkekreyegyellkekealerqkeaIERQL 246
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   892 QAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLED--EEEMNA------ELTAKKRKLEDECSELKRDIDDLELTLAK 963
Cdd:TIGR02169  247 ASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDlgEEEQLRvkekigELEAEIASLERSIAEKERELEDAEERLAK 326
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   964 VEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKK 1043
Cdd:TIGR02169  327 LEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREINELKR 406
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1044 VRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFE--------------LNALNARIEDEQALGSQLQKKLK 1109
Cdd:TIGR02169  407 ELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEikkqewkleqlaadLSKYEQELYDLKEEYDRVEKELS 486
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1110 ELQARIEELEEELEAERTA----RAKVEKLRSDLS------RELEEISER----LEEAGG----ATSVQIEMNKKREAEF 1171
Cdd:TIGR02169  487 KLQRELAEAEAQARASEERvrggRAVEEVLKASIQgvhgtvAQLGSVGERyataIEVAAGnrlnNVVVEDDAVAKEAIEL 566
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1172 QKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKeksEFKLELDDvTSNMEQIIKAKANLEKM-CR 1250
Cdd:TIGR02169  567 LKRRKAGRATFLPLNKMRDERRDLSILSEDGVIGFAVDLVEFDPKYEP---AFKYVFGD-TLVVEDIEAARRLMGKYrMV 642
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1251 TLEDQMNEhRSKA-----EETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGK---LTYTQQLEDLKRQLEEE 1322
Cdd:TIGR02169  643 TLEGELFE-KSGAmtggsRAPRGGILFSRSEPAELQRLRERLEGLKRELSSLQSELRRIEnrlDELSQELSDASRKIGEI 721
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1323 VKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQwrtkYETDAIQRTEELEEAKKKLAQrlqeaeE 1402
Cdd:TIGR02169  722 EKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEE----LEEDLHKLEEALNDLEARLSH------S 791
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1403 AVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELF 1482
Cdd:TIGR02169  792 RIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELE 871
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1483 KLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEgKILRAQ 1562
Cdd:TIGR02169  872 ELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDE-EIPEEE 950
                          810
                   ....*....|....*.
gi 124302198  1563 LEFNQIKAEIERKLAE 1578
Cdd:TIGR02169  951 LSLEDVQAELQRVEEE 966
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
978-1860 1.81e-21

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 102.45  E-value: 1.81e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   978 LTEEMAGLDEIIAKLTKEKKALQEAHQQaLDDLQAEEDKVNtltkakvkleQQVDDLEGslEQEKKVR-MDLERAKRKLE 1056
Cdd:TIGR02169  158 IIDEIAGVAEFDRKKEKALEELEEVEEN-IERLDLIIDEKR----------QQLERLRR--EREKAERyQALLKEKREYE 224
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1057 GDLKLTQesIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEaeRTARAKVEKLR 1136
Cdd:TIGR02169  225 GYELLKE--KEALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLGEEEQ--LRVKEKIGELE 300
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1137 SDLS---RELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATA---AALRKKHADSVAELGEQIDNL 1210
Cdd:TIGR02169  301 AEIAsleRSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTeeyAELKEELEDLRAELEEVDKEF 380
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1211 QRVKQKLekekSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEetqrsvnDLTSQRAKLQTENGELSRQ 1290
Cdd:TIGR02169  381 AETRDEL----KDYREKLEKLKREINELKRELDRLQEELQRLSEELADLNAAIA-------GIEAKINELEEEKEDKALE 449
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1291 LDEKEALISQLTRGKLTYTQQLEDLK---RQLEEEV-KAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKAnS 1366
Cdd:TIGR02169  450 IKKQEWKLEQLAADLSKYEQELYDLKeeyDRVEKELsKLQRELAEAEAQARASEERVRGGRAVEEVLKASIQGVHGTV-A 528
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1367 EVAQWRTKYETdaiqrteELEEAkkkLAQRLQEAEEAVEAVNAKCSSLEKTKH--RLQ----NEIEDLMVDVERSNAAAA 1440
Cdd:TIGR02169  529 QLGSVGERYAT-------AIEVA---AGNRLNNVVVEDDAVAKEAIELLKRRKagRATflplNKMRDERRDLSILSEDGV 598
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1441 A--------LDKKQRN-----------FDKILAEWKQ-------------------------KYEESQSELESSQKEARS 1476
Cdd:TIGR02169  599 IgfavdlveFDPKYEPafkyvfgdtlvVEDIEAARRLmgkyrmvtlegelfeksgamtggsrAPRGGILFSRSEPAELQR 678
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1477 LSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVR-------KQLEAEKMELQSALEEAEA 1549
Cdd:TIGR02169  679 LRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEeklkerlEELEEDLSSLEQEIENVKS 758
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1550 SLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDslqtsldaETRSRNEALrvkkkmegdLNEMEIQL 1629
Cdd:TIGR02169  759 ELKELEARIEELEEDLHKLEEALNDLEARLSHSRIPEIQAELSKLE--------EEVSRIEAR---------LREIEQKL 821
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1630 SHANRMAAEAQKQVKSLQSLlkdtqiqlddavraNDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIET 1709
Cdd:TIGR02169  822 NRLTLEKEYLEKEIQELQEQ--------------RIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDL 887
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1710 SErvqllhsqntslinQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKkeqdtsaHLERMKKNMEQt 1789
Cdd:TIGR02169  888 KK--------------ERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELS-------EIEDPKGEDEE- 945
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1790 ikdlqhrlDEAEQIALKGGKKQLQKLEARVRELE-------NELEAEQKRNAESVKGMRK--SERR-IKELTYQTEEDRK 1859
Cdd:TIGR02169  946 --------IPEEELSLEDVQAELQRVEEEIRALEpvnmlaiQEYEEVLKRLDELKEKRAKleEERKaILERIEEYEKKKR 1017

                   .
gi 124302198  1860 N 1860
Cdd:TIGR02169 1018 E 1018
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
841-1512 3.33e-21

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 101.67  E-value: 3.33e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   841 KSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKM-------VSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKI 913
Cdd:TIGR02168  345 KLEELKEELESLEAELEELEAELEELESRLEELEEQLetlrskvAQLELQIASLNNEIERLEARLERLEDRRERLQQEIE 424
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   914 QL-----EAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKV---KNLTEEMAGL 985
Cdd:TIGR02168  425 ELlkkleEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLdslERLQENLEGF 504
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   986 DEIIAKLTKEKKALQEAHQQALDDLQAEED---KVNT-----LTKAKVKLEQQVDDLEGSLEQEKKVRMDL-------ER 1050
Cdd:TIGR02168  505 SEGVKALLKNQSGLSGILGVLSELISVDEGyeaAIEAalggrLQAVVVENLNAAKKAIAFLKQNELGRVTFlpldsikGT 584
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1051 AKRKLEGDLKLTQESIMDLENDKQQLDERLKK------------KDFElNALNARIE----------------------- 1095
Cdd:TIGR02168  585 EIQGNDREILKNIEGFLGVAKDLVKFDPKLRKalsyllggvlvvDDLD-NALELAKKlrpgyrivtldgdlvrpggvitg 663
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1096 -DEQALGSQLQKK--LKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAggatsvqiemnkkrEAEFQ 1172
Cdd:TIGR02168  664 gSAKTNSSILERRreIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEEL--------------SRQIS 729
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1173 KMRRDLEEATLQHEATAAALRKKHADsVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTL 1252
Cdd:TIGR02168  730 ALRKDLARLEAEVEQLEERIAQLSKE-LTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDEL 808
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1253 EDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHA 1332
Cdd:TIGR02168  809 RAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEA 888
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1333 LQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCS 1412
Cdd:TIGR02168  889 LALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLTLEEAEALENKIEDDEE 968
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1413 SLEKTKHRLQNEIEDLmvdverSNAAAAALDKkqrnfdkiLAEWKQKYEESQselessqKEARSLSTELFKLKNAYEE-- 1490
Cdd:TIGR02168  969 EARRRLKRLENKIKEL------GPVNLAAIEE--------YEELKERYDFLT-------AQKEDLTEAKETLEEAIEEid 1027
                          730       740
                   ....*....|....*....|....*
gi 124302198  1491 ---SLEHLETFKRENKNLQEEISDL 1512
Cdd:TIGR02168 1028 reaRERFKDTFDQVNENFQRVFPKL 1052
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
917-1793 1.18e-20

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 99.76  E-value: 1.18e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   917 AKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRdIDDLELTLAKVE-----KEKHATENKVKNLTEEMAGLDEIIAK 991
Cdd:TIGR02169  177 EELEEVEENIERLDLIIDEKRQQLERLRREREKAER-YQALLKEKREYEgyellKEKEALERQKEAIERQLASLEEELEK 255
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   992 LTKEKKALQEAHQQALDDLQAEEDKVNTLTKAK-VKLEQQVDDLEGSLEQekkvrmdlerakrkLEGDLKLTQESIMDLE 1070
Cdd:TIGR02169  256 LTEEISELEKRLEEIEQLLEELNKKIKDLGEEEqLRVKEKIGELEAEIAS--------------LERSIAEKERELEDAE 321
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1071 NDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERL 1150
Cdd:TIGR02169  322 ERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREI 401
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1151 EEAggatsvqiemnKKREAEFQKMRRDLEEATLQHEATAAALRKKHAdsvaelgeqidnlqrvkqKLEKEKSEFKLELDD 1230
Cdd:TIGR02169  402 NEL-----------KRELDRLQEELQRLSEELADLNAAIAGIEAKIN------------------ELEEEKEDKALEIKK 452
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1231 VTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEA-------LISQLTR 1303
Cdd:TIGR02169  453 QEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQARASEERVRGGRAVEEVLKAsiqgvhgTVAQLGS 532
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1304 GKLTYTQQLEDLKRQ------LEEEVKAKNA--LAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKY 1375
Cdd:TIGR02169  533 VGERYATAIEVAAGNrlnnvvVEDDAVAKEAieLLKRRKAGRATFLPLNKMRDERRDLSILSEDGVIGFAVDLVEFDPKY 612
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1376 ETD---AIQRT---EELEEAKK--------KLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAA 1441
Cdd:TIGR02169  613 EPAfkyVFGDTlvvEDIEAARRlmgkyrmvTLEGELFEKSGAMTGGSRAPRGGILFSRSEPAELQRLRERLEGLKRELSS 692
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1442 LDKKQRNFDKILAEWKQKyeesqselessqkeARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGK 1521
Cdd:TIGR02169  693 LQSELRRIENRLDELSQE--------------LSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKS 758
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1522 TIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEF-NQIKAEIERKLAEKDeemeqAKRNHLRVVDSLQTS 1600
Cdd:TIGR02169  759 ELKELEARIEELEEDLHKLEEALNDLEARLSHSRIPEIQAELSKlEEEVSRIEARLREIE-----QKLNRLTLEKEYLEK 833
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1601 LDAETRSRNEALRVKKKMEGD-LNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDavranddlkeniaiverrnn 1679
Cdd:TIGR02169  834 EIQELQEQRIDLKEQIKSIEKeIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDE-------------------- 893
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1680 lLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKM------DADLSQLQTEVEEAVQECRNAEE 1753
Cdd:TIGR02169  894 -LEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDeeipeeELSLEDVQAELQRVEEEIRALEP 972
                          890       900       910       920
                   ....*....|....*....|....*....|....*....|
gi 124302198  1754 KAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDL 1793
Cdd:TIGR02169  973 VNMLAIQEYEEVLKRLDELKEKRAKLEEERKAILERIEEY 1012
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
1286-1828 6.16e-20

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 97.31  E-value: 6.16e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1286 ELSRQLDEKEALISQLTRGKLTytQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKAN 1365
Cdd:COG1196   217 ELKEELKELEAELLLLKLRELE--AELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELL 294
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1366 SEVAQwrtkyetdAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKK 1445
Cdd:COG1196   295 AELAR--------LEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEA 366
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1446 QRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHE 1525
Cdd:COG1196   367 LLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEE 446
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1526 LEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEM---EQAKRNHLR---------- 1592
Cdd:COG1196   447 AAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEgflEGVKAALLLaglrglagav 526
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1593 -VVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEI-------QLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRAN 1664
Cdd:COG1196   527 aVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAieylkaaKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVAS 606
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1665 DDLKENIAIVERRNNLLQAELEELRA--------VVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQ 1736
Cdd:COG1196   607 DLREADARYYVLGDTLLGRTLVAARLeaalrravTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAE 686
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1737 LQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLE 1816
Cdd:COG1196   687 RLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELE 766
                         570
                  ....*....|....*
gi 124302198 1817 ---ARvreLENELEA 1828
Cdd:COG1196   767 relER---LEREIEA 778
MYSc_Myo33 cd14894
class myosin, motor domain; Class XXXIII myosins have variable numbers of IQ domain and 2 ...
220-706 1.10e-19

class myosin, motor domain; Class XXXIII myosins have variable numbers of IQ domain and 2 tandem ANK repeats that are separated by a PH domain. The myosin classes XXX to XXXIV contain members from Phytophthora species and Hyaloperonospora parasitica. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276859 [Multi-domain]  Cd Length: 871  Bit Score: 96.35  E-value: 1.10e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  220 IIQANPALEAFGNAKTVRNDNSSRFGKF--IRIHFGATG---KLASADIETYLLEKSRVIFQL------KAERDYHIFYQ 288
Cdd:cd14894   249 VLDSNIVLEAFGHATTSMNLNSSRFGKMttLQVAFGLHPwefQICGCHISPFLLEKSRVTSERgresgdQNELNFHILYA 328
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  289 ILSNKKPELLDMLLITNNPYD------YAFISQGETTVASIDDAEELMATD--------NAFDVLGFTSEEKNSMYKLTG 354
Cdd:cd14894   329 MVAGVNAFPFMRLLAKELHLDgidcsaLTYLGRSDHKLAGFVSKEDTWKKDverwqqviDGLDELNVSPDEQKTIFKVLS 408
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  355 AIMHFGNMKFKLKQREEQAEPDGT---EEADKSAYLMGLNSADLLKGLCHPR---VKVGNEYVTKGQNVQQVIYATGALA 428
Cdd:cd14894   409 AVLWLGNIELDYREVSGKLVMSSTgalNAPQKVVELLELGSVEKLERMLMTKsvsLQSTSETFEVTLEKGQVNHVRDTLA 488
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  429 KAVYERMFNWMV------TRINATLETKQPRQY-----------FIGVLDIAGFEIFDFNSFEQLCINFTNEKLqqffnh 491
Cdd:cd14894   489 RLLYQLAFNYVVfvmneaTKMSALSTDGNKHQMdsnasapeavsLLKIVDVFGFEDLTHNSLDQLCINYLSEKL------ 562
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  492 hmFVLEQEEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTF-----KAKLFDNHL--GKSANFQ 564
Cdd:cd14894   563 --YAREEQVIAVAYSSRPHLTARDSEKDVLFIYEHPLGVFASLEELTILHQSENMNAqqeekRNKLFVRNIydRNSSRLP 640
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  565 KPRNIKGKPEAH---------FSLIHYAGIVDYNIIGWLQKNKDPL-NETVVGLYQKSSLKLLSTLFANYAGADAPIEKG 634
Cdd:cd14894   641 EPPRVLSNAKRHtpvllnvlpFVIPHTRGNVIYDANDFVKKNSDFVyANLLVGLKTSNSSHFCRMLNESSQLGWSPNTNR 720
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 124302198  635 KGKAKKGSSFQTVSAL---HRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICR 706
Cdd:cd14894   721 SMLGSAESRLSGTKSFvgqFRSHVNVLTSQDDKNMPFYFHCIRPNAKKQPSLVNNDLVEQQCRSQRLIRQMEICR 795
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
847-1589 2.82e-19

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 95.13  E-value: 2.82e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   847 KEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERL 926
Cdd:TIGR02169  294 EKIGELEAEIASLERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAEL 373
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   927 EDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAhqqa 1006
Cdd:TIGR02169  374 EEVDKEFAETRDELKDYREKLEKLKREINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALE---- 449
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1007 lddLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLK----- 1081
Cdd:TIGR02169  450 ---IKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQARASEERVRGGRAVEEVLKASIQgvhgt 526
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1082 -------KKDFEL-------NALNARIEDEQALGSQLQKKLKELQArieeleeeleaERTARAKVEKLRsDLSRELEEIS 1147
Cdd:TIGR02169  527 vaqlgsvGERYATaievaagNRLNNVVVEDDAVAKEAIELLKRRKA-----------GRATFLPLNKMR-DERRDLSILS 594
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1148 ErlEEAGGATSVQIEMNKKREAEFQKMRRD------LEEA----------TLQHE-------ATAAALRKKHADSVA-EL 1203
Cdd:TIGR02169  595 E--DGVIGFAVDLVEFDPKYEPAFKYVFGDtlvvedIEAArrlmgkyrmvTLEGElfeksgaMTGGSRAPRGGILFSrSE 672
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1204 GEQIDNLQRVKQKLEKEKSEFKLELddvtsnmeqiikakanlekmcRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTE 1283
Cdd:TIGR02169  673 PAELQRLRERLEGLKRELSSLQSEL---------------------RRIENRLDELSQELSDASRKIGEIEKEIEQLEQE 731
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1284 NGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQsarhdcDLLREQYEEETEakaELQRVLSK 1363
Cdd:TIGR02169  732 EEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALN------DLEARLSHSRIP---EIQAELSK 802
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1364 ANSEVAQWRtkyetdaiQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALD 1443
Cdd:TIGR02169  803 LEEEVSRIE--------ARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELE 874
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1444 KKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKnlqeEISDLTEQLGSSGKTI 1523
Cdd:TIGR02169  875 AALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELS----EIEDPKGEDEEIPEEE 950
                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 124302198  1524 HELEKVRKQLEAEKMELQsALEEAE--ASLEHEEGKILRAQLEFNQIKAEIERK-LAEKDEEMEQAKRN 1589
Cdd:TIGR02169  951 LSLEDVQAELQRVEEEIR-ALEPVNmlAIQEYEEVLKRLDELKEKRAKLEEERKaILERIEEYEKKKRE 1018
PTZ00121 PTZ00121
MAEBL; Provisional
841-1435 5.14e-19

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 94.82  E-value: 5.14e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  841 KSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSllQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIqlEAKVK 920
Cdd:PTZ00121 1261 RMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAE--EKKKADEAKKKAEEAKKADEAKKKAEEAKKKA--DAAKK 1336
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  921 EMNERLEDEEEMNAELTAKKRKLEDecSELKRDIDDLEltlaKVEKEKHATENKVKnlTEEMAGLDEIIAKLTKEKKALQ 1000
Cdd:PTZ00121 1337 KAEEAKKAAEAAKAEAEAAADEAEA--AEEKAEAAEKK----KEEAKKKADAAKKK--AEEKKKADEAKKKAEEDKKKAD 1408
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1001 EAHQQALDDLQAEEdkvntlTKAKVKLEQQVDDLEGSLEQEKKVrmdlERAKRKLEGDLKltqesimdLENDKQQLDERL 1080
Cdd:PTZ00121 1409 ELKKAAAAKKKADE------AKKKAEEKKKADEAKKKAEEAKKA----DEAKKKAEEAKK--------AEEAKKKAEEAK 1470
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1081 KKKDFELNALNARIEDEqalgsqLQKKLKELQARIEELEEELEAERTA---RAKVEKLRSDLSRELEEiSERLEEAGGAT 1157
Cdd:PTZ00121 1471 KADEAKKKAEEAKKADE------AKKKAEEAKKKADEAKKAAEAKKKAdeaKKAEEAKKADEAKKAEE-AKKADEAKKAE 1543
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1158 SVQI--EMNKKREAEFQKMRRDLEEATLQHEATAAALRKkhadsvAELGEQIDNlQRVKQKLEKEKSEFKLELDDVTSNM 1235
Cdd:PTZ00121 1544 EKKKadELKKAEELKKAEEKKKAEEAKKAEEDKNMALRK------AEEAKKAEE-ARIEEVMKLYEEEKKMKAEEAKKAE 1616
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1236 EQIIKAkanlekmcrtledqmnEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDL 1315
Cdd:PTZ00121 1617 EAKIKA----------------EELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEA 1680
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1316 KRQLEEEVKAKNALAHALQSARhDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAiQRTEEL---EEAKKK 1392
Cdd:PTZ00121 1681 KKAEEDEKKAAEALKKEAEEAK-KAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDK-KKAEEAkkdEEEKKK 1758
                         570       580       590       600
                  ....*....|....*....|....*....|....*....|...
gi 124302198 1393 LAQRLQEAEEAVEAVNAKCSSLekTKHRLQNEIEDLMVDVERS 1435
Cdd:PTZ00121 1759 IAHLKKEEEKKAEEIRKEKEAV--IEEELDEEDEKRRMEVDKK 1799
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
987-1801 6.41e-19

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 94.03  E-value: 6.41e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   987 EIIAKLTKE--KKALQEAHQQaLDDLQAEEDKVNTL-TKAKVKLEQQVDDLEGSLEQ---EKKVRMDLERAKRKLEGDLK 1060
Cdd:pfam15921   66 KIIAYPGKEhiERVLEEYSHQ-VKDLQRRLNESNELhEKQKFYLRQSVIDLQTKLQEmqmERDAMADIRRRESQSQEDLR 144
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1061 -LTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQAR-----IEELEEELEAERTARAKVEK 1134
Cdd:pfam15921  145 nQLQNTVHELEAAKCLKEDMLEDSNTQIEQLRKMMLSHEGVLQEIRSILVDFEEAsgkkiYEHDSMSTMHFRSLGSAISK 224
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1135 LRSDLSRELEEISERLEEAGGA-TSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRV 1213
Cdd:pfam15921  225 ILRELDTEISYLKGRIFPVEDQlEALKSESQNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQLEII 304
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1214 KQKLEKEKSEFKLELDDVTSNMEQIikaKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLde 1293
Cdd:pfam15921  305 QEQARNQNSMYMRQLSDLESTVSQL---RSELREAKRMYEDKIEELEKQLVLANSELTEARTERDQFSQESGNLDDQL-- 379
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1294 kEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHalqsarhdcdlLREQYEEETEAKAELQRVLSKANSEvAQWRT 1373
Cdd:pfam15921  380 -QKLLADLHKREKELSLEKEQNKRLWDRDTGNSITIDH-----------LRRELDDRNMEVQRLEALLKAMKSE-CQGQM 446
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1374 KYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLmvdversnaaAAALDKKQRNFDKIL 1453
Cdd:pfam15921  447 ERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTVSDL----------TASLQEKERAIEATN 516
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1454 AEwkqkYEESQSELESSQKEARSLSTELFKLKNAYEESlEHLETFKRENKN----LQEEISDLTEQLGSSGKTIHELEKV 1529
Cdd:pfam15921  517 AE----ITKLRSRVDLKLQELQHLKNEGDHLRNVQTEC-EALKLQMAEKDKvieiLRQQIENMTQLVGQHGRTAGAMQVE 591
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1530 RKQLEAE----KMELQS---ALEEAEASLEHEEGKILRAQLE-FNQIKAEIERKLAEKDEEMEQAK-RNHLRVVDSLQTS 1600
Cdd:pfam15921  592 KAQLEKEindrRLELQEfkiLKDKKDAKIRELEARVSDLELEkVKLVNAGSERLRAVKDIKQERDQlLNEVKTSRNELNS 671
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1601 LDAETRSRNEALRVK-KKMEGDLNEMEIQLShanrmaaEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNN 1679
Cdd:pfam15921  672 LSEDYEVLKRNFRNKsEEMETTTNKLKMQLK-------SAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQID 744
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1680 LLQAELEELRAVVEQTERSRKLAEQELIETSERVqllhsqnTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAI 1759
Cdd:pfam15921  745 ALQSKIQFLEEAMTNANKEKHFLKEEKNKLSQEL-------STVATEKNKMAGELEVLRSQERRLKEKVANMEVALDKAS 817
                          810       820       830       840
                   ....*....|....*....|....*....|....*....|..
gi 124302198  1760 TDAAMMAEELKKEQDTSAHLErmkknmeqtikdLQHRLDEAE 1801
Cdd:pfam15921  818 LQFAECQDIIQRQEQESVRLK------------LQHTLDVKE 847
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
1128-1907 7.04e-19

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 94.03  E-value: 7.04e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1128 ARAKVEKLRSDLSRELEEISERLEEAGgatsvqiEMNKKREAEFQK----MRRDLEEATLQHEATAAaLRKKHADSVAEL 1203
Cdd:pfam15921   72 GKEHIERVLEEYSHQVKDLQRRLNESN-------ELHEKQKFYLRQsvidLQTKLQEMQMERDAMAD-IRRRESQSQEDL 143
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1204 GEQidnLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLED-----------QMNEHRSKAEETQRSVND 1272
Cdd:pfam15921  144 RNQ---LQNTVHELEAAKCLKEDMLEDSNTQIEQLRKMMLSHEGVLQEIRSilvdfeeasgkKIYEHDSMSTMHFRSLGS 220
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1273 LTSQRAK-LQTENGELSRQL----DEKEALISQLTRGKLTYTQQLEDLKRQL--EEEVKAkNALAHALQSARHDCDLLRE 1345
Cdd:pfam15921  221 AISKILReLDTEISYLKGRIfpveDQLEALKSESQNKIELLLQQHQDRIEQLisEHEVEI-TGLTEKASSARSQANSIQS 299
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1346 QYE----EETEAKAELQRVLSKANSEVAQWRTkyetdaiqrteELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHR- 1420
Cdd:pfam15921  300 QLEiiqeQARNQNSMYMRQLSDLESTVSQLRS-----------ELREAKRMYEDKIEELEKQLVLANSELTEARTERDQf 368
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1421 ------LQNEIEDLMVDV-ERSNAAAAALDKKQRNFDKILAEwKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLE 1493
Cdd:pfam15921  369 sqesgnLDDQLQKLLADLhKREKELSLEKEQNKRLWDRDTGN-SITIDHLRRELDDRNMEVQRLEALLKAMKSECQGQME 447
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1494 -HLETFKRENKNLqEEISDLTEQLGSsgkTIHELEKVRKQLEAEKMELQSA---LEEAEASLEHEEGKILRAQLEFNQIK 1569
Cdd:pfam15921  448 rQMAAIQGKNESL-EKVSSLTAQLES---TKEMLRKVVEELTAKKMTLESSertVSDLTASLQEKERAIEATNAEITKLR 523
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1570 AEIERKLaekdEEMEQAKR--NHLRVVdslQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQ 1647
Cdd:pfam15921  524 SRVDLKL----QELQHLKNegDHLRNV---QTECEALKLQMAEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLE 596
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1648 SLLKDTQIQLDDAVRANDdlKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQElietSERVQLLHSQNTSLiNQK 1727
Cdd:pfam15921  597 KEINDRRLELQEFKILKD--KKDAKIRELEARVSDLELEKVKLVNAGSERLRAVKDIK----QERDQLLNEVKTSR-NEL 669
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1728 KKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEE----LKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAE-- 1801
Cdd:pfam15921  670 NSLSEDYEVLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQtrntLKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQsk 749
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1802 ----QIALKGGKKQLQKLEARVRELENELEA---EQKRNAESVKGMRKSERRIKEltyqteedrkNLLRLQDLVDKLQLK 1874
Cdd:pfam15921  750 iqflEEAMTNANKEKHFLKEEKNKLSQELSTvatEKNKMAGELEVLRSQERRLKE----------KVANMEVALDKASLQ 819
                          810       820       830
                   ....*....|....*....|....*....|...
gi 124302198  1875 VkAYKRQAEEAEEQANTNLskfrKVQHELDEAE 1907
Cdd:pfam15921  820 F-AECQDIIQRQEQESVRL----KLQHTLDVKE 847
PTZ00121 PTZ00121
MAEBL; Provisional
845-1525 7.20e-19

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 94.44  E-value: 7.20e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  845 REKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQleaKVKEMNE 924
Cdd:PTZ00121 1158 RKAEDARKAEEARKAEDAKKAEAARKAEEVRKAEELRKAEDARKAEAARKAEEERKAEEARKAEDAKKAE---AVKKAEE 1234
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  925 RLEDEEEmnAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNlTEEMAGLDEiiAKLTKEKKALQEAHQ 1004
Cdd:PTZ00121 1235 AKKDAEE--AKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKK-AEEKKKADE--AKKAEEKKKADEAKK 1309
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1005 QALDDLQAEEDKVNT------LTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDE 1078
Cdd:PTZ00121 1310 KAEEAKKADEAKKKAeeakkkADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEE 1389
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1079 RLKKKDfelnaLNARIEDEQALGSQLQKKLKElqaRIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATS 1158
Cdd:PTZ00121 1390 KKKADE-----AKKKAEEDKKKADELKKAAAA---KKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEE 1461
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1159 VQIEMNKKREAEfqKMRRDLEEATLQHEATAAALR-KKHADSVAELGEQIDNLQRVKQKLEKEKSEfKLELDDVTSNMEQ 1237
Cdd:PTZ00121 1462 AKKKAEEAKKAD--EAKKKAEEAKKADEAKKKAEEaKKKADEAKKAAEAKKKADEAKKAEEAKKAD-EAKKAEEAKKADE 1538
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1238 IIKA--KANLEKMCRTLEDQMNEHRSKAEETQRSvndltSQRAKLQTENGELSRQLDEKEaLISQLTRGKLTYTQQLEDL 1315
Cdd:PTZ00121 1539 AKKAeeKKKADELKKAEELKKAEEKKKAEEAKKA-----EEDKNMALRKAEEAKKAEEAR-IEEVMKLYEEEKKMKAEEA 1612
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1316 KRQLEEEVKAKNalAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAiQRTEEL----EEAKK 1391
Cdd:PTZ00121 1613 KKAEEAKIKAEE--LKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDK-KKAEEAkkaeEDEKK 1689
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1392 KLAQRLQEAEEA--VEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSnaaaaaldKKQRNFDKILAEWKQKYEESQSELES 1469
Cdd:PTZ00121 1690 AAEALKKEAEEAkkAEELKKKEAEEKKKAEELKKAEEENKIKAEEA--------KKEAEEDKKKAEEAKKDEEEKKKIAH 1761
                         650       660       670       680       690
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 124302198 1470 SQKEARSLSTELFKLKNAYEEslehlETFKRENKNLQEEISDLTEQLGSSGKTIHE 1525
Cdd:PTZ00121 1762 LKKEEEKKAEEIRKEKEAVIE-----EELDEEDEKRRMEVDKKIKDIFDNFANIIE 1812
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
870-1425 1.84e-18

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 92.41  E-value: 1.84e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  870 RKELEEKmvsllqEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTakkrkledecsE 949
Cdd:PRK02224  193 KAQIEEK------EEKDLHERLNGLESELAELDEEIERYEEQREQARETRDEADEVLEEHEERREELE-----------T 255
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  950 LKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKE---KKALQEAHQQALDDLQAEEDKV-NTLTKAKV 1025
Cdd:PRK02224  256 LEAEIEDLRETIAETEREREELAEEVRDLRERLEELEEERDDLLAEaglDDADAEAVEARREELEDRDEELrDRLEECRV 335
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1026 KLEQQVDDLEGSLEQEKKVRmdlERAKRK------LEGDLKLTQESIMDLENDKQQLDErlkkkdfELNALNARIEDEQA 1099
Cdd:PRK02224  336 AAQAHNEEAESLREDADDLE---ERAEELreeaaeLESELEEAREAVEDRREEIEELEE-------EIEELRERFGDAPV 405
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1100 LGSQLQKKLKELQARIEEleeeleaertARAKVEKLRSDLSRELEEISE--RLEEAGG--------ATSVQIEMNKKREA 1169
Cdd:PRK02224  406 DLGNAEDFLEELREERDE----------LREREAELEATLRTARERVEEaeALLEAGKcpecgqpvEGSPHVETIEEDRE 475
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1170 EFQKMRRDLEEATLQHEATAAALRKkhADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMC 1249
Cdd:PRK02224  476 RVEELEAELEDLEEEVEEVEERLER--AEDLVEAEDRIERLEERREDLEELIAERRETIEEKRERAEELRERAAELEAEA 553
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1250 RTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSR---QLDEKEALISQLT--RGKLTYTQQLEDLKR-QLEEEV 1323
Cdd:PRK02224  554 EEKREAAAEAEEEAEEAREEVAELNSKLAELKERIESLERirtLLAAIADAEDEIErlREKREALAELNDERReRLAEKR 633
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1324 KAKNALAHALQSARhdcdllreqYEEETEAKAELQRVLSKANSEVAQWRTkyETDAIQRT--------EELEEAKKKLAQ 1395
Cdd:PRK02224  634 ERKRELEAEFDEAR---------IEEAREDKERAEEYLEQVEEKLDELRE--ERDDLQAEigavenelEELEELRERREA 702
                         570       580       590
                  ....*....|....*....|....*....|
gi 124302198 1396 rLQEAEEAVEAVNAKCSSLEKTKHRLQNEI 1425
Cdd:PRK02224  703 -LENRVEALEALYDEAEELESMYGDLRAEL 731
PTZ00121 PTZ00121
MAEBL; Provisional
1077-1883 3.17e-18

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 92.13  E-value: 3.17e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1077 DERLK--KKDFELNALNARIEDEQAlgSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAG 1154
Cdd:PTZ00121 1069 DEGLKpsYKDFDFDAKEDNRADEAT--EEAFGKAEEAKKTETGKAEEARKAEEAKKKAEDARKAEEARKAEDARKAEEAR 1146
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1155 GATSVQIEMNKKREAEFQKMR--RDLEEATLQHEA-TAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEfKLELDDV 1231
Cdd:PTZ00121 1147 KAEDAKRVEIARKAEDARKAEeaRKAEDAKKAEAArKAEEVRKAEELRKAEDARKAEAARKAEEERKAEEAR-KAEDAKK 1225
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1232 TSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSvnDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQ 1311
Cdd:PTZ00121 1226 AEAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMA--HFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKK 1303
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1312 LEDLKRQLEEEVKAKNALAHAlQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRteelEEAKK 1391
Cdd:PTZ00121 1304 ADEAKKKAEEAKKADEAKKKA-EEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKK----EEAKK 1378
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1392 KLAQRLQEAEEAVEAVNAKCSSLEktkhrlqneiedlmvdversnaaaaalDKKQRNFDKILAEWKQKyEESQSELESSQ 1471
Cdd:PTZ00121 1379 KADAAKKKAEEKKKADEAKKKAEE---------------------------DKKKADELKKAAAAKKK-ADEAKKKAEEK 1430
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1472 KEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASL 1551
Cdd:PTZ00121 1431 KKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKK 1510
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1552 EHEEGKilRAQlefNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEmeiqlsh 1631
Cdd:PTZ00121 1511 KADEAK--KAE---EAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNM------- 1578
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1632 ANRMAAEAQKQVKSlqsllkdtqiQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSE 1711
Cdd:PTZ00121 1579 ALRKAEEAKKAEEA----------RIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKK 1648
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1712 RVQLLHSQNTSLINQkkkmdADLSQLQTEVEEAVQECRNAEEKAKKAitdaammAEELKKEQDTSAHLERMKKNMEQTIK 1791
Cdd:PTZ00121 1649 AEELKKAEEENKIKA-----AEEAKKAEEDKKKAEEAKKAEEDEKKA-------AEALKKEAEEAKKAEELKKKEAEEKK 1716
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1792 dlqhrldEAEQIalkggKKQLQKLEARVRELENELEaEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKL 1871
Cdd:PTZ00121 1717 -------KAEEL-----KKAEEENKIKAEEAKKEAE-EDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEE 1783
                         810
                  ....*....|..
gi 124302198 1872 QLKVKAYKRQAE 1883
Cdd:PTZ00121 1784 ELDEEDEKRRME 1795
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
1253-1927 3.48e-18

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 91.78  E-value: 3.48e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1253 EDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLD-------EKEALISQLTRGKLTYTQQLEDLKRQLEEEVKA 1325
Cdd:pfam01576   11 EEELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQLQaetelcaEAEEMRARLAARKQELEEILHELESRLEEEEER 90
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1326 KNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEeLEEAKKKLAQRLQEAEEAVE 1405
Cdd:pfam01576   91 SQQLQNEKKKMQQHIQDLEEQLDEEEAARQKLQLEKVTTEAKIKKLEEDILLLEDQNSK-LSKERKLLEERISEFTSNLA 169
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1406 AVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLK 1485
Cdd:pfam01576  170 EEEEKAKSLSKLKNKHEAMISDLEERLKKEEKGRQELEKAKRKLEGESTDLQEQIAELQAQIAELRAQLAKKEEELQAAL 249
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1486 NAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEF 1565
Cdd:pfam01576  250 ARLEEETAQKNNALKKIRELEAQISELQEDLESERAARNKAEKQRRDLGEELEALKTELEDTLDTTAAQQELRSKREQEV 329
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1566 NQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKS 1645
Cdd:pfam01576  330 TELKKALEEETRSHEAQLQEMRQKHTQALEELTEQLEQAKRNKANLEKAKQALESENAELQAELRTLQQAKQDSEHKRKK 409
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1646 LQSLLKDTQIQLDDAVRANDDLKEniaiverRNNLLQAELEELRAVVEQTE-RSRKLA------EQELIETSERVQLLHS 1718
Cdd:pfam01576  410 LEGQLQELQARLSESERQRAELAE-------KLSKLQSELESVSSLLNEAEgKNIKLSkdvsslESQLQDTQELLQEETR 482
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1719 QNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLD 1798
Cdd:pfam01576  483 QKLNLSTRLRQLEDERNSLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKKLEEDAGTLEALEEGKKRLQRELEALTQQLE 562
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1799 EAEQIALKggkkqLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTyqtEEDRKNLLRLQDLVDKlqlkvkay 1878
Cdd:pfam01576  563 EKAAAYDK-----LEKTKNRLQQELDDLLVDLDHQRQLVSNLEKKQKKFDQML---AEEKAISARYAEERDR-------- 626
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....*....
gi 124302198  1879 krqaeeAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDI 1927
Cdd:pfam01576  627 ------AEAEAREKETRALSLARALEEALEAKEELERTNKQLRAEMEDL 669
PTZ00121 PTZ00121
MAEBL; Provisional
1230-1911 8.06e-18

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 90.97  E-value: 8.06e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1230 DVTSNMEQIIKAKANLEKMcRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQ----TENGELSRQLDEKEALISQLTRGK 1305
Cdd:PTZ00121 1051 DIDGNHEGKAEAKAHVGQD-EGLKPSYKDFDFDAKEDNRADEATEEAFGKAEeakkTETGKAEEARKAEEAKKKAEDARK 1129
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1306 LTYTQQLEDLkRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQR--VLSKANSEVAQWRTKYETDAIQRT 1383
Cdd:PTZ00121 1130 AEEARKAEDA-RKAEEARKAEDAKRVEIARKAEDARKAEEARKAEDAKKAEAARkaEEVRKAEELRKAEDARKAEAARKA 1208
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1384 EE---LEEAKK----KLAQRLQEAEEA-VEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAE 1455
Cdd:PTZ00121 1209 EEerkAEEARKaedaKKAEAVKKAEEAkKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEE 1288
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1456 WKQKYEESQSELESSQKEARSLSTELFK---LKNAYEESLEHLETFKR--ENKNLQEEISDLTEQlgssgKTIHELEKVR 1530
Cdd:PTZ00121 1289 KKKADEAKKAEEKKKADEAKKKAEEAKKadeAKKKAEEAKKKADAAKKkaEEAKKAAEAAKAEAE-----AAADEAEAAE 1363
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1531 KQLEAEKMELQSALEEAEASLEHEEGKI----LRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETR 1606
Cdd:PTZ00121 1364 EKAEAAEKKKEEAKKKADAAKKKAEEKKkadeAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEA 1443
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1607 SRNEALRvKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLlKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAE-- 1684
Cdd:PTZ00121 1444 KKADEAK-KKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKA-DEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEea 1521
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1685 --LEELRAVvEQTERSRKLAEQELIETSERV----QLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQ-ECRNAEEKAKK 1757
Cdd:PTZ00121 1522 kkADEAKKA-EEAKKADEAKKAEEKKKADELkkaeELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKaEEARIEEVMKL 1600
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1758 AITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQI-----------ALKGGKKQLQKLEARVRELENEL 1826
Cdd:PTZ00121 1601 YEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKkkaeelkkaeeENKIKAAEEAKKAEEDKKKAEEA 1680
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1827 ---EAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAE---EQANTNLSKFRKVQ 1900
Cdd:PTZ00121 1681 kkaEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKkkaEEAKKDEEEKKKIA 1760
                         730
                  ....*....|.
gi 124302198 1901 HELDEAEERAD 1911
Cdd:PTZ00121 1761 HLKKEEEKKAE 1771
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
843-1455 2.14e-17

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 88.97  E-value: 2.14e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   843 AEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEM 922
Cdd:TIGR02169  374 EEVDKEFAETRDELKDYREKLEKLKREINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQ 453
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   923 NERLE-------DEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKE 995
Cdd:TIGR02169  454 EWKLEqlaadlsKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQARASEERVRGGRAVEEVLKASIQGVHGTVAQLGSV 533
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   996 KKALQEAHQQAL----------DDLQAEED--------------------KVNTLTKAKVKLEQQVDDLEGSLEQEKKVR 1045
Cdd:TIGR02169  534 GERYATAIEVAAgnrlnnvvveDDAVAKEAiellkrrkagratflplnkmRDERRDLSILSEDGVIGFAVDLVEFDPKYE 613
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1046 -------------MDLERAKR--------KLEGDL--------------KLTQESIMDLENDKQQLDERLKKKDFELNAL 1090
Cdd:TIGR02169  614 pafkyvfgdtlvvEDIEAARRlmgkyrmvTLEGELfeksgamtggsrapRGGILFSRSEPAELQRLRERLEGLKRELSSL 693
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1091 NARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAggatsvqiemnkkrEAE 1170
Cdd:TIGR02169  694 QSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENV--------------KSE 759
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1171 FQKMRRDLEEatlqHEATAAALRKKHADSVAELG-EQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMC 1249
Cdd:TIGR02169  760 LKELEARIEE----LEEDLHKLEEALNDLEARLShSRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEI 835
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1250 RTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEevkaknaL 1329
Cdd:TIGR02169  836 QELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEE-------L 908
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1330 AHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQwrTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNA 1409
Cdd:TIGR02169  909 EAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDEEIPEE--ELSLEDVQAELQRVEEEIRALEPVNMLAIQEYEEVLK 986
                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|.
gi 124302198  1410 KCSSLEKTKHRLQNEIEDL-----MVDVERSNAAAAALDKKQRNFDKILAE 1455
Cdd:TIGR02169  987 RLDELKEKRAKLEEERKAIlerieEYEKKKREVFMEAFEAINENFNEIFAE 1037
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
931-1785 3.56e-17

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 88.49  E-value: 3.56e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   931 EMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDL 1010
Cdd:pfam02463  166 RLKRKKKEALKKLIEETENLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQEL 245
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1011 QAEEDKVNTLTKAKVKLEQQvddlegSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNAL 1090
Cdd:pfam02463  246 LRDEQEEIESSKQEIEKEEE------KLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKES 319
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1091 NARIEdeqalgsQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAE 1170
Cdd:pfam02463  320 EKEKK-------KAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKL 392
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1171 FQKM----------RRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIK 1240
Cdd:pfam02463  393 KEEElelkseeekeAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSED 472
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1241 AKANLEKMCRTLEDQMNEHRSKAEEtqrsvnDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLE 1320
Cdd:pfam02463  473 LLKETQLVKLQEQLELLLSRQKLEE------RSQKESKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKVAIS 546
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1321 EEVKAKNALAHAlqsarhDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEA 1400
Cdd:pfam02463  547 TAVIVEVSATAD------EVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDK 620
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1401 EEAVEAVNAKCSSLEKTKHRLQNEIEDLM--VDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLS 1478
Cdd:pfam02463  621 RAKVVEGILKDTELTKLKESAKAKESGLRkgVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLE 700
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1479 TELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKI 1558
Cdd:pfam02463  701 IKKKEQREKEELKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEER 780
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1559 LRAQLEFNQIKAEIERKLAEKDEEMEQAKRNH----LRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQlsHANR 1634
Cdd:pfam02463  781 EKTEKLKVEEEKEEKLKAQEEELRALEEELKEeaelLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEE--ELER 858
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1635 MAAEAQKQVKSLQSLLKDTQIQLDDAVRanddlkENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQ 1714
Cdd:pfam02463  859 LEEEITKEELLQELLLKEEELEEQKLKD------ELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEILLK 932
                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 124302198  1715 LLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKN 1785
Cdd:pfam02463  933 YEEEPEELLLEEADEKEKEENNKEEEEERNKRLLLAKEELGKVNLMAIEEFEEKEERYNKDELEKERLEEE 1003
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
858-1573 5.92e-17

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 87.38  E-value: 5.92e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   858 RLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLiKNKIQ-LEAKVKEMNERLEDEEEMNAEL 936
Cdd:TIGR04523   23 GYKNIANKQDTEEKQLEKKLKTIKNELKNKEKELKNLDKNLNKDEEKINNS-NNKIKiLEQQIKDLNDKLKKNKDKINKL 101
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   937 TAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATE-------NKVKNLTEEMAGLDEIIAKLTKEKKALqeahqqaldd 1009
Cdd:TIGR04523  102 NSDLSKINSEIKNDKEQKNKLEVELNKLEKQKKENKknidkflTEIKKKEKELEKLNNKYNDLKKQKEEL---------- 171
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1010 lqaeEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLErakrKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNA 1089
Cdd:TIGR04523  172 ----ENELNLLEKEKLNIQKNIDKIKNKLLKLELLLSNLK----KKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINE 243
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1090 LNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEaggatsvqiEMNKKREA 1169
Cdd:TIGR04523  244 KTTEISNTQTQLNQLKDEQNKIKKQLSEKQKELEQNNKKIKELEKQLNQLKSEISDLNNQKEQ---------DWNKELKS 314
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1170 EFQKMRRDLEEATLQheataaalRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMC 1249
Cdd:TIGR04523  315 ELKNQEKKLEEIQNQ--------ISQNNKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEI 386
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1250 RTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLtrgkltyTQQLEDLKRQLEEEVKAKNAL 1329
Cdd:TIGR04523  387 KNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKN-------NSEIKDLTNQDSVKELIIKNL 459
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1330 AHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVaqwrtkyetdaiqrtEELEEAKKKLAQRLQEAEEAVEAVNA 1409
Cdd:TIGR04523  460 DNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKEL---------------KKLNEEKKELEEKVKDLTKKISSLKE 524
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1410 KCSSLEKTKHRLQNEIEDLMVDVER--SNAAAAALDKKQRNFDKILAEWKQKYEesqselessqkearslstelfKLKNA 1487
Cdd:TIGR04523  525 KIEKLESEKKEKESKISDLEDELNKddFELKKENLEKEIDEKNKEIEELKQTQK---------------------SLKKK 583
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1488 YEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQ 1567
Cdd:TIGR04523  584 QEEKQELIDQKEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKLKQEVKQIKETIKEIRNKWPE 663

                   ....*.
gi 124302198  1568 IKAEIE 1573
Cdd:TIGR04523  664 IIKKIK 669
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
854-1729 1.49e-16

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 86.56  E-value: 1.49e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   854 EEFTRLKEALEKsearRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERcdQLIKNKIQLEAKVKEMNERLEDEEEMN 933
Cdd:pfam02463  166 RLKRKKKEALKK----LIEETENLAELIIDLEELKLQELKLKEQAKKALEY--YQLKEKLELEEEYLLYLDYLKLNEERI 239
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   934 AELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAE 1013
Cdd:pfam02463  240 DLLQELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKES 319
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1014 EDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEgdlkltqesiMDLENDKQQLDERLKKKDFELNALNAR 1093
Cdd:pfam02463  320 EKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELE----------KLQEKLEQLEEELLAKKKLESERLSSA 389
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1094 IEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQK 1173
Cdd:pfam02463  390 AKLKEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKK 469
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1174 MRRDLEEATLQHEATAAALRkkhadsvaelgEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLE 1253
Cdd:pfam02463  470 SEDLLKETQLVKLQEQLELL-----------LSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAV 538
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1254 DQMNEHRSKAEETQRS-VNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHA 1332
Cdd:pfam02463  539 ENYKVAISTAVIVEVSaTADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADED 618
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1333 LQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDaiQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCS 1412
Cdd:pfam02463  619 DKRAKVVEGILKDTELTKLKESAKAKESGLRKGVSLEEGLAEKSEV--KASLSELTKELLEIQELQEKAESELAKEEILR 696
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1413 SLEKTKHRLQNEIEDL-MVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNaYEES 1491
Cdd:pfam02463  697 RQLEIKKKEQREKEELkKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSL-KEKE 775
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1492 LEHLETFKRENKNLQEEISDLTEQLGSsgktihELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAE 1571
Cdd:pfam02463  776 LAEEREKTEKLKVEEEKEEKLKAQEEE------LRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLE 849
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1572 IERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLShanRMAAEAQKQVKSLQSLLK 1651
Cdd:pfam02463  850 KLAEEELERLEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQK---LNLLEEKENEIEERIKEE 926
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1652 DTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQ--ELIETSERVQLLHSQNTSLINQKKK 1729
Cdd:pfam02463  927 AEILLKYEEEPEELLLEEADEKEKEENNKEEEEERNKRLLLAKEELGKVNLMAieEFEEKEERYNKDELEKERLEEEKKK 1006
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
972-1654 3.00e-16

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 85.07  E-value: 3.00e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   972 ENKVKNLTEEMAGLDEIIAKLTKEKKALQEahqqalDDLQAEEDKVNTLTKAKvKLEQQVDDLEGSLEQEKKVRMDLERA 1051
Cdd:TIGR04523   32 DTEEKQLEKKLKTIKNELKNKEKELKNLDK------NLNKDEEKINNSNNKIK-ILEQQIKDLNDKLKKNKDKINKLNSD 104
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1052 KRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAK 1131
Cdd:TIGR04523  105 LSKINSEIKNDKEQKNKLEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLEKEKLN 184
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1132 VEKLRSDLSRELEEISERLeeaggatsVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQ 1211
Cdd:TIGR04523  185 IQKNIDKIKNKLLKLELLL--------SNLKKKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLN 256
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1212 RVKQKLEKEKSEfkleLDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEetQRSVNDLTSQRAKLQTENGELSRQL 1291
Cdd:TIGR04523  257 QLKDEQNKIKKQ----LSEKQKELEQNNKKIKELEKQLNQLKSEISDLNNQKE--QDWNKELKSELKNQEKKLEEIQNQI 330
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1292 DEKEALISQLTrgkltytQQLEDLKRQLEEEVKAKNalahalqsarhdcdllrEQYEEETEAKAELQRVLSKANSEvaqw 1371
Cdd:TIGR04523  331 SQNNKIISQLN-------EQISQLKKELTNSESENS-----------------EKQRELEEKQNEIEKLKKENQSY---- 382
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1372 rtkyetdaIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDK 1451
Cdd:TIGR04523  383 --------KQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKEL 454
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1452 ILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRK 1531
Cdd:TIGR04523  455 IIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKK 534
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1532 QLEAEKMELQSALEEaeasleheegkilraqLEFNQIKAEIERKLAEKDEEMEQAKRNhlrvvdslQTSLDAETRSRNEA 1611
Cdd:TIGR04523  535 EKESKISDLEDELNK----------------DDFELKKENLEKEIDEKNKEIEELKQT--------QKSLKKKQEEKQEL 590
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....*..
gi 124302198  1612 LRVKKKMEGDLN----EMEIQLSHANRMAAEAQKQVKSLQSLLKDTQ 1654
Cdd:TIGR04523  591 IDQKEKEKKDLIkeieEKEKKISSLEKELEKAKKENEKLSSIIKNIK 637
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
1270-1927 1.05e-15

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 83.58  E-value: 1.05e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1270 VNDLTSQRAKLQTENGELSRQLDEKEALISQLTrgkltytQQLEDLKRQLEEEVKAKN-----------ALAHALQSARH 1338
Cdd:TIGR02169  165 VAEFDRKKEKALEELEEVEENIERLDLIIDEKR-------QQLERLRREREKAERYQAllkekreyegyELLKEKEALER 237
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1339 DCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTK 1418
Cdd:TIGR02169  238 QKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLGEEEQLRVKEKIGELEAEIASLERSIAEKEREL 317
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1419 HRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETF 1498
Cdd:TIGR02169  318 EDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKL 397
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1499 KRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIER---K 1575
Cdd:TIGR02169  398 KREINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDlkeE 477
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1576 LAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEG------DLNEME------IQLSHANRM-------- 1635
Cdd:TIGR02169  478 YDRVEKELSKLQRELAEAEAQARASEERVRGGRAVEEVLKASIQGvhgtvaQLGSVGeryataIEVAAGNRLnnvvvedd 557
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1636 --AAEAQKQVKS-------------LQSLLKDTQIQLDDAVRAN-------DDLKENIAIVERRNNLLQAELEELRAVVE 1693
Cdd:TIGR02169  558 avAKEAIELLKRrkagratflplnkMRDERRDLSILSEDGVIGFavdlvefDPKYEPAFKYVFGDTLVVEDIEAARRLMG 637
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1694 Q----------------------TERSRKL----AEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQE 1747
Cdd:TIGR02169  638 KyrmvtlegelfeksgamtggsrAPRGGILfsrsEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRK 717
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1748 CRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQiALKGGKKQLQKLEAR-----VREL 1822
Cdd:TIGR02169  718 IGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEE-DLHKLEEALNDLEARlshsrIPEI 796
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1823 ENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHE 1902
Cdd:TIGR02169  797 QAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAA 876
                          730       740
                   ....*....|....*....|....*
gi 124302198  1903 LDEAEERADIAESQVNKLRAKSRDI 1927
Cdd:TIGR02169  877 LRDLESRLGDLKKERDELEAQLREL 901
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1258-1840 1.08e-15

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 83.17  E-value: 1.08e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1258 EHRSKAEETQRSVNDLTSQRaklQTENGELSRQLDEKEA--LISQLTRgkltytqqLEDLKRQLEEEVKAKNALAHALQS 1335
Cdd:PRK02224  166 EYRERASDARLGVERVLSDQ---RGSLDQLKAQIEEKEEkdLHERLNG--------LESELAELDEEIERYEEQREQARE 234
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1336 ARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYET------DAIQRTEELEEAKKKLAQRLQEAEEAVEAVNA 1409
Cdd:PRK02224  235 TRDEADEVLEEHEERREELETLEAEIEDLRETIAETEREREElaeevrDLRERLEELEEERDDLLAEAGLDDADAEAVEA 314
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1410 KCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQkyeesqselessqkEARSLSTELfklknayE 1489
Cdd:PRK02224  315 RREELEDRDEELRDRLEECRVAAQAHNEEAESLREDADDLEERAEELRE--------------EAAELESEL-------E 373
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1490 ESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIK 1569
Cdd:PRK02224  374 EAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELREERDELREREAELEATLRTARERVEEAEALLEAGK 453
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1570 -----------------AEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDA-ETRSRNEALRVKKKMEGDL-NEMEIQLS 1630
Cdd:PRK02224  454 cpecgqpvegsphvetiEEDRERVEELEAELEDLEEEVEEVEERLERAEDLvEAEDRIERLEERREDLEELiAERRETIE 533
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1631 HANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERsRKLAEQELIETS 1710
Cdd:PRK02224  534 EKRERAEELRERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAELKERIESLERIRTLLAA-IADAEDEIERLR 612
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1711 ERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEA-VQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQT 1789
Cdd:PRK02224  613 EKREALAELNDERRERLAEKRERKRELEAEFDEArIEEAREDKERAEEYLEQVEEKLDELREERDDLQAEIGAVENELEE 692
                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 124302198 1790 IKDLQHRLDeaeqiALKGGKKQLQKLEARVRELEN---ELEAE-QKRNAESVKGM 1840
Cdd:PRK02224  693 LEELRERRE-----ALENRVEALEALYDEAEELESmygDLRAElRQRNVETLERM 742
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1174-1871 1.08e-15

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 83.43  E-value: 1.08e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1174 MRRDLEEATLQHEATAAAlrKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDvtsnmEQIIKAKANLEKmcrtLE 1253
Cdd:COG4913   240 AHEALEDAREQIELLEPI--RELAERYAAARERLAELEYLRAALRLWFAQRRLELLE-----AELEELRAELAR----LE 308
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1254 DQMNEHRSKAEETQRSVNDLTSQRAKLQTEN-GELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHA 1332
Cdd:COG4913   309 AELERLEARLDALREELDELEAQIRGNGGDRlEQLEREIERLERELEERERRRARLEALLAALGLPLPASAEEFAALRAE 388
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1333 LQSARHDCDLLREQYEEeteAKAELQRVLSKANSEVAQWRTkyETDAIQRT-----EELEEAKKKLAQRLQEAEEAVEAV 1407
Cdd:COG4913   389 AAALLEALEEELEALEE---ALAEAEAALRDLRRELRELEA--EIASLERRksnipARLLALRDALAEALGLDEAELPFV 463
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1408 nakCSSLE-KTKHRL-QNEIE--------DLMVDVERSNAAAAALDK---KQR-NFDKIlaewkqkyEESQSELESSQKE 1473
Cdd:COG4913   464 ---GELIEvRPEEERwRGAIErvlggfalTLLVPPEHYAAALRWVNRlhlRGRlVYERV--------RTGLPDPERPRLD 532
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1474 ARSLSTELFKLKNAYEESLEHL-------------ETFKRENKNLQEE--ISDLTE--------------QLGSSGKT-I 1523
Cdd:COG4913   533 PDSLAGKLDFKPHPFRAWLEAElgrrfdyvcvdspEELRRHPRAITRAgqVKGNGTrhekddrrrirsryVLGFDNRAkL 612
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1524 HELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILR----AQLEFNQIK-AEIERKLAEKDEEMEQAKRNHlRVVDSLQ 1598
Cdd:COG4913   613 AALEAELAELEEELAEAEERLEALEAELDALQERREAlqrlAEYSWDEIDvASAEREIAELEAELERLDASS-DDLAALE 691
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1599 TSLDAetrsrnealrvkkkMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAvranddlkeniaiVERRN 1678
Cdd:COG4913   692 EQLEE--------------LEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAA-------------EDLAR 744
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1679 NLLQAELEELRAVVEQTERSRKLAEQelietservqllhsqntsLINQKKKMDADLSQLQTEVEEAVQE-CRNAEEKAKK 1757
Cdd:COG4913   745 LELRALLEERFAAALGDAVERELREN------------------LEERIDALRARLNRAEEELERAMRAfNREWPAETAD 806
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1758 AITDAAMMAEELK-----KEQDTSAHLERMK----KNMEQTIKDLQHRLDEAEQIAlkggKKQLQKLEARVRELE-NE-- 1825
Cdd:COG4913   807 LDADLESLPEYLAlldrlEEDGLPEYEERFKellnENSIEFVADLLSKLRRAIREI----KERIDPLNDSLKRIPfGPgr 882
                         730       740       750       760       770
                  ....*....|....*....|....*....|....*....|....*....|.
gi 124302198 1826 ---LEAEQKRNAEsVKGMRKSERRIKELTYQTEED--RKNLLRLQDLVDKL 1871
Cdd:COG4913   883 ylrLEARPRPDPE-VREFRQELRAVTSGASLFDEElsEARFAALKRLIERL 932
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
1484-1926 2.29e-15

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 82.47  E-value: 2.29e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1484 LKNAYEESLEHLETfkreNKNLQEEIsdlteqLGSSGKTIHELEKVRKQLEAEKMELQSAL---EEAEASLEHEEGKIlr 1560
Cdd:pfam15921  143 LRNQLQNTVHELEA----AKCLKEDM------LEDSNTQIEQLRKMMLSHEGVLQEIRSILvdfEEASGKKIYEHDSM-- 210
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1561 AQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTsLDAETRSRNEAL--RVKKKMEGDLNEMEIQLSHANRMAAE 1638
Cdd:pfam15921  211 STMHFRSLGSAISKILRELDTEISYLKGRIFPVEDQLEA-LKSESQNKIELLlqQHQDRIEQLISEHEVEITGLTEKASS 289
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1639 AQKQVKSLQSLLKDTQIQlddavranddlkeniaiVERRNNLLQAELEELRAVVEQTE---RSRKLAEQELIETSERVQL 1715
Cdd:pfam15921  290 ARSQANSIQSQLEIIQEQ-----------------ARNQNSMYMRQLSDLESTVSQLRselREAKRMYEDKIEELEKQLV 352
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1716 LhsqntslinqkkkMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQH 1795
Cdd:pfam15921  353 L-------------ANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRR 419
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1796 RLDEAEQialkggkkQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKV 1875
Cdd:pfam15921  420 ELDDRNM--------EVQRLEALLKAMKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTL 491
                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1876 KAYKR----------QAEEAEEQANTNLSKFR--------KVQHELDEAEERADI-AESQVNKLRAKSRD 1926
Cdd:pfam15921  492 ESSERtvsdltaslqEKERAIEATNAEITKLRsrvdlklqELQHLKNEGDHLRNVqTECEALKLQMAEKD 561
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
845-1580 3.47e-15

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 82.02  E-value: 3.47e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   845 REKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLadaeeRCDQLIKNKIQLEAKVKEMNE 924
Cdd:TIGR00606  310 HQRTVREKERELVDCQRELEKLNKERRLLNQEKTELLVEQGRLQLQADRHQEHI-----RARDSLIQSLATRLELDGFER 384
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   925 RLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQ 1004
Cdd:TIGR00606  385 GPFSERQIKNFHTLVIERQEDEAKTAAQLCADLQSKERLKQEQADEIRDEKKGLGRTIELKKEILEKKQEELKFVIKELQ 464
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1005 QALDDLQAEEDKVNTLTKAKVKLEQ-----QVDDLEGSLEQEKKVRMDLERAKRKLEGDL------KLTQESIMDLENDK 1073
Cdd:TIGR00606  465 QLEGSSDRILELDQELRKAERELSKaeknsLTETLKKEVKSLQNEKADLDRKLRKLDQEMeqlnhhTTTRTQMEMLTKDK 544
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1074 QQLDERLKKKDF----ELNALNARIEDEQALGSQLQKKLKE---LQARIEELEEELEAERTARAKVEKLRSDLSRELEEI 1146
Cdd:TIGR00606  545 MDKDEQIRKIKSrhsdELTSLLGYFPNKKQLEDWLHSKSKEinqTRDRLAKLNKELASLEQNKNHINNELESKEEQLSSY 624
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1147 SERLEEAGGATSVQIEMNKKREaEFQKMRRDLE-------------EATLQHEATAAALRKKHADSVAELGEQIDNLQRV 1213
Cdd:TIGR00606  625 EDKLFDVCGSQDEESDLERLKE-EIEKSSKQRAmlagatavysqfiTQLTDENQSCCPVCQRVFQTEAELQEFISDLQSK 703
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1214 KQKLEKEKSEFKLELDDVTSNMEQII---KAKAN-LEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSR 1289
Cdd:TIGR00606  704 LRLAPDKLKSTESELKKKEKRRDEMLglaPGRQSiIDLKEKEIPELRNKLQKVNRDIQRLKNDIEEQETLLGTIMPEEES 783
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1290 QLDEK------EALISQLTRGKLTYTQQLE-----DLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQ 1358
Cdd:TIGR00606  784 AKVCLtdvtimERFQMELKDVERKIAQQAAklqgsDLDRTVQQVNQEKQEKQHELDTVVSKIELNRKLIQDQQEQIQHLK 863
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1359 RVLSKANSEVAQWRTkyetdAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAA 1438
Cdd:TIGR00606  864 SKTNELKSEKLQIGT-----NLQRRQQFEEQLVELSTEVQSLIREIKDAKEQDSPLETFLEKDQQEKEELISSKETSNKK 938
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1439 AA-ALDKKQRNFDKILAEWK--QKYEESQSELESSQKEarslsTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQ 1515
Cdd:TIGR00606  939 AQdKVNDIKEKVKNIHGYMKdiENKIQDGKDDYLKQKE-----TELNTVNAQLEECEKHQEKINEDMRLMRQDIDTQKIQ 1013
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1516 ---------LGSSGKTIHELEKVRKQLEAEKMELQ--------SALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAE 1578
Cdd:TIGR00606 1014 erwlqdnltLRKRENELKEVEEELKQHLKEMGQMQvlqmkqehQKLEENIDLIKRNHVLALGRQKGYEKEIKHFKKELRE 1093

                   ..
gi 124302198  1579 KD 1580
Cdd:TIGR00606 1094 PQ 1095
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
840-1401 4.40e-15

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 81.70  E-value: 4.40e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   840 LKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNladAEERCDQLIKNKIQLEAKV 919
Cdd:pfam15921  250 LKSESQNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQLEIIQEQ---ARNQNSMYMRQLSDLESTV 326
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   920 kemnerledeEEMNAELTAKKRKLEDECSELKRD--IDDLELTLAKVEKEKHATENkvKNLTEEmagLDEIIAKLTKEKK 997
Cdd:pfam15921  327 ----------SQLRSELREAKRMYEDKIEELEKQlvLANSELTEARTERDQFSQES--GNLDDQ---LQKLLADLHKREK 391
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   998 ALQEAHQQ--------------------ALDDLQAEEDKVNTLTKA-----KVKLEQQVDDLEG---SLEQEKKVRMDLE 1049
Cdd:pfam15921  392 ELSLEKEQnkrlwdrdtgnsitidhlrrELDDRNMEVQRLEALLKAmksecQGQMERQMAAIQGkneSLEKVSSLTAQLE 471
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1050 RAKRKLEGDLKLTQESIMDLENDKQ---QLDERLKKKDFELNALNARIedeQALGSQLQKKLKELQ------ARIEELEE 1120
Cdd:pfam15921  472 STKEMLRKVVEELTAKKMTLESSERtvsDLTASLQEKERAIEATNAEI---TKLRSRVDLKLQELQhlknegDHLRNVQT 548
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1121 ELEAERTARAKVEKLRSDLSRELEEISERLEEAG-GATSVQIEmNKKREAEFQKMRRDLEEATLqheataaaLRKKHADS 1199
Cdd:pfam15921  549 ECEALKLQMAEKDKVIEILRQQIENMTQLVGQHGrTAGAMQVE-KAQLEKEINDRRLELQEFKI--------LKDKKDAK 619
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1200 VAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIK----AKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTS 1275
Cdd:pfam15921  620 IRELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNevktSRNELNSLSEDYEVLKRNFRNKSEEMETTTNKLKM 699
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1276 QRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQ----------LEEEVKAKNALAHALQSARH------- 1338
Cdd:pfam15921  700 QLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQidalqskiqfLEEAMTNANKEKHFLKEEKNklsqels 779
                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 124302198  1339 -----------DCDLLREQYEEETEAKAELQRVLSKANSEVAQWRtkyetDAIQRTEElEEAKKKLAQRLQEAE 1401
Cdd:pfam15921  780 tvateknkmagELEVLRSQERRLKEKVANMEVALDKASLQFAECQ-----DIIQRQEQ-ESVRLKLQHTLDVKE 847
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
900-1574 1.63e-14

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 79.57  E-value: 1.63e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  900 DAEERCDQLIKNKIQLEakvkEMNERLEDEEEmNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATenKVKNLT 979
Cdd:COG4913   222 DTFEAADALVEHFDDLE----RAHEALEDARE-QIELLEPIRELAERYAAARERLAELEYLRAALRLWFAQR--RLELLE 294
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  980 EEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTL-TKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGD 1058
Cdd:COG4913   295 AELEELRAELARLEAELERLEARLDALREELDELEAQIRGNgGDRLEQLEREIERLERELEERERRRARLEALLAALGLP 374
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1059 LKLTQEsimDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIeeleeeleaertarAKVEKLRSD 1138
Cdd:COG4913   375 LPASAE---EFAALRAEAAALLEALEEELEALEEALAEAEAALRDLRRELRELEAEI--------------ASLERRKSN 437
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1139 LSRELEEISERLEEAGGATSVQ-------IEMnKKREAEFqkmrRDLEEATLQHEATAAALRKKHADSVAELGEQID--- 1208
Cdd:COG4913   438 IPARLLALRDALAEALGLDEAElpfvgelIEV-RPEEERW----RGAIERVLGGFALTLLVPPEHYAAALRWVNRLHlrg 512
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1209 --NLQRVKQKLEKEKSEF--------KLELDD--VTSNMEQIIKAKANLEKmCRTLEDQMNEHRS-------KAEETQRS 1269
Cdd:COG4913   513 rlVYERVRTGLPDPERPRldpdslagKLDFKPhpFRAWLEAELGRRFDYVC-VDSPEELRRHPRAitragqvKGNGTRHE 591
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1270 VNDLTSQRAKLQT--ENGelsRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQy 1347
Cdd:COG4913   592 KDDRRRIRSRYVLgfDNR---AKLAALEAELAELEEELAEAEERLEALEAELDALQERREALQRLAEYSWDEIDVASAE- 667
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1348 EEETEAKAELQRvLSKANSEVaqwrtkyetdaiqrtEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIED 1427
Cdd:COG4913   668 REIAELEAELER-LDASSDDL---------------AALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDE 731
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1428 LMVDVErsnaAAAALDKKQRNFDkiLAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNlqe 1507
Cdd:COG4913   732 LQDRLE----AAEDLARLELRAL--LEERFAAALGDAVERELRENLEERIDALRARLNRAEEELERAMRAFNREWPA--- 802
                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1508 EISDLTEQLGSsgktIHELEKVRKQLEAEKM-ELQSALEEAEASLEHEEGKILRAQL--EFNQIKAEIER 1574
Cdd:COG4913   803 ETADLDADLES----LPEYLALLDRLEEDGLpEYEERFKELLNENSIEFVADLLSKLrrAIREIKERIDP 868
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
852-1516 2.01e-14

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 79.00  E-value: 2.01e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   852 MKEEFTRLKEALEKSEARRKELEEKMVSLlqeKNDLQLQVQAEQDNLADAEercdqliKNKIQLEAKVKEMNERLED-EE 930
Cdd:pfam05483  160 LKETCARSAEKTKKYEYEREETRQVYMDL---NNNIEKMILAFEELRVQAE-------NARLEMHFKLKEDHEKIQHlEE 229
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   931 EMNAELTAKKRK---LEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQAL 1007
Cdd:pfam05483  230 EYKKEINDKEKQvslLLIQITEKENKMKDLTFLLEESRDKANQLEEKTKLQDENLKELIEKKDHLTKELEDIKMSLQRSM 309
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1008 DDLQAEEDKVNTLTKAKVKL----EQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKK 1083
Cdd:pfam05483  310 STQKALEEDLQIATKTICQLteekEAQMEELNKAKAAHSFVVTEFEATTCSLEELLRTEQQRLEKNEDQLKIITMELQKK 389
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1084 DFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISErLEEAGGATSVQIEM 1163
Cdd:pfam05483  390 SSELEEMTKFKNNKEVELEELKKILAEDEKLLDEKKQFEKIAEELKGKEQELIFLLQAREKEIHD-LEIQLTAIKTSEEH 468
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1164 NKKreaEFQKMRRDLEEATLQHeataaalrkkhadsvAELGEQIDNLQRVKQKLEKEKSEFKLELDDvtsNMEQIIKAKA 1243
Cdd:pfam05483  469 YLK---EVEDLKTELEKEKLKN---------------IELTAHCDKLLLENKELTQEASDMTLELKK---HQEDIINCKK 527
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1244 NLEKMCRTLEDqmnehrskAEETQRSV-NDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQ---L 1319
Cdd:pfam05483  528 QEERMLKQIEN--------LEEKEMNLrDELESVREEFIQKGDEVKCKLDKSEENARSIEYEVLKKEKQMKILENKcnnL 599
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1320 EEEVKAKNALAHALQsarHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQE 1399
Cdd:pfam05483  600 KKQIENKNKNIEELH---QENKALKKKGSAENKQLNAYEIKVNKLELELASAKQKFEEIIDNYQKEIEDKKISEEKLLEE 676
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1400 AEEAVEAVNAKCSSLEKTKHRLQNEIEDLMvdversnaaaAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLST 1479
Cdd:pfam05483  677 VEKAKAIADEAVKLQKEIDKRCQHKIAEMV----------ALMEKHKHQYDKIIEERDSELGLYKNKEQEQSSAKAALEI 746
                          650       660       670
                   ....*....|....*....|....*....|....*..
gi 124302198  1480 ELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQL 1516
Cdd:pfam05483  747 ELSNIKAELLSLKKQLEIEKEEKEKLKMEAKENTAIL 783
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
962-1428 2.09e-14

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 79.31  E-value: 2.09e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  962 AKVEKEKHAT----ENKVKNLTEEMAGLDE--IIAKLTKEKKALQ-EAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDL 1034
Cdd:PRK02224  198 EKEEKDLHERlnglESELAELDEEIERYEEqrEQARETRDEADEVlEEHEERREELETLEAEIEDLRETIAETEREREEL 277
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1035 EGSLEQEKKVRMDLERAKRKLEGDLKLT-------QESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKK 1107
Cdd:PRK02224  278 AEEVRDLRERLEELEEERDDLLAEAGLDdadaeavEARREELEDRDEELRDRLEECRVAAQAHNEEAESLREDADDLEER 357
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1108 LKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEA----GGATSVQIEMN------KKREAEFQKMRRD 1177
Cdd:PRK02224  358 AEELREEAAELESELEEAREAVEDRREEIEELEEEIEELRERFGDApvdlGNAEDFLEELReerdelREREAELEATLRT 437
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1178 LEEATLQHEATAAALR----------KKHADSVAELGEQIDnlqrvkqKLEKEKSEFKLELDDVTSNMEQIIKAKA---- 1243
Cdd:PRK02224  438 ARERVEEAEALLEAGKcpecgqpvegSPHVETIEEDRERVE-------ELEAELEDLEEEVEEVEERLERAEDLVEaedr 510
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1244 --NLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTEnGELSRQLDEKEALISQLTRGKL-TYTQQLEDLKRQLE 1320
Cdd:PRK02224  511 ieRLEERREDLEELIAERRETIEEKRERAEELRERAAELEAE-AEEKREAAAEAEEEAEEAREEVaELNSKLAELKERIE 589
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1321 EEVKAKNALAhALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIqrtEELEEAKKKLAQRLQEA 1400
Cdd:PRK02224  590 SLERIRTLLA-AIADAEDEIERLREKREALAELNDERRERLAEKRERKRELEAEFDEARI---EEAREDKERAEEYLEQV 665
                         490       500
                  ....*....|....*....|....*...
gi 124302198 1401 EEAVEAVNAKCSSLEKTKHRLQNEIEDL 1428
Cdd:PRK02224  666 EEKLDELREERDDLQAEIGAVENELEEL 693
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
880-1700 2.81e-14

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 79.11  E-value: 2.81e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   880 LLQEKNDLQLQVQAEQDNLADAEERC---DQLIKNKIQLEAK---VKEMNERLEDEEEMNAEltaKKRKLEDECSELKRD 953
Cdd:pfam12128  153 TLLGRERVELRSLARQFALCDSESPLrhiDKIAKAMHSKEGKfrdVKSMIVAILEDDGVVPP---KSRLNRQQVEHWIRD 229
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   954 IDdlelTLAKVEKEKHatenKVKNLTEEMAGLDEIIAKLTKEKKALQEaHQQALDDLQAEEDKvntltkAKVKLEQQVDD 1033
Cdd:pfam12128  230 IQ----AIAGIMKIRP----EFTKLQQEFNTLESAELRLSHLHFGYKS-DETLIASRQEERQE------TSAELNQLLRT 294
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1034 LEGSLeqekkvrmdlerakrklegdlkltQESIMDLENDKQQLDERLKKKDFELNALNARiedeqalgsqlqkKLKELQA 1113
Cdd:pfam12128  295 LDDQW------------------------KEKRDELNGELSAADAAVAKDRSELEALEDQ-------------HGAFLDA 337
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1114 RIEeleeeleaerTARAKVEKLRSdLSRELEEISERLE-EAGGATSVQIEMNKKREAEFQKMRRDL-----------EEA 1181
Cdd:pfam12128  338 DIE----------TAAADQEQLPS-WQSELENLEERLKaLTGKHQDVTAKYNRRRSKIKEQNNRDIagikdklakirEAR 406
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1182 TLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANlekmcrtlEDQMNEHRS 1261
Cdd:pfam12128  407 DRQLAVAEDDLQALESELREQLEAGKLEFNEEEYRLKSRLGELKLRLNQATATPELLLQLENF--------DERIERARE 478
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1262 KAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTrgkltytQQLEDLKRQL------------EEEVKAKNAL 1329
Cdd:pfam12128  479 EQEAANAEVERLQSELRQARKRRDQASEALRQASRRLEERQ-------SALDELELQLfpqagtllhflrKEAPDWEQSI 551
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1330 AHALQSAR-HDCDLLREQYEEETEAKAELQRV-LSKANSEVAQWrtkyetdaIQRTEELEEakkklaqRLQEAEEAVEAV 1407
Cdd:pfam12128  552 GKVISPELlHRTDLDPEVWDGSVGGELNLYGVkLDLKRIDVPEW--------AASEEELRE-------RLDKAEEALQSA 616
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1408 NAKCSSLEKTKHRLQNEIEDLmvDVERSNAAAA---ALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKL 1484
Cdd:pfam12128  617 REKQAAAEEQLVQANGELEKA--SREETFARTAlknARLDLRRLFDEKQSEKDKKNKALAERKDSANERLNSLEAQLKQL 694
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1485 KNAYEESLEHLETFKRENKN-----LQEEISDLTEQLGSSGKTIhelEKVRKQLEAEKMELQSALEEAEASLEHEEGKIL 1559
Cdd:pfam12128  695 DKKHQAWLEEQKEQKREARTekqayWQVVEGALDAQLALLKAAI---AARRSGAKAELKALETWYKRDLASLGVDPDVIA 771
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1560 RaqlefnqIKAEIeRKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRvkkKMEGDLNEMEIQLShanRMAAEA 1639
Cdd:pfam12128  772 K-------LKREI-RTLERKIERIAVRRQEVLRYFDWYQETWLQRRPRLATQLS---NIERAISELQQQLA---RLIADT 837
                          810       820       830       840       850       860
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 124302198  1640 QKQVKSLQSLLK---DTQIQLDDAVRANDDLKENIAIVERRNNLLQAELE--ELRAVVEQTERSRK 1700
Cdd:pfam12128  838 KLRRAKLEMERKaseKQQVRLSENLRGLRCEMSKLATLKEDANSEQAQGSigERLAQLEDLKLKRD 903
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
841-1414 3.45e-14

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 78.68  E-value: 3.45e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   841 KSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAE--------------QDNLADAEERCD 906
Cdd:pfam01576  455 KNIKLSKDVSSLESQLQDTQELLQEETRQKLNLSTRLRQLEDERNSLQEQLEEEeeakrnverqlstlQAQLSDMKKKLE 534
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   907 QLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLD 986
Cdd:pfam01576  535 EDAGTLEALEEGKKRLQRELEALTQQLEEKAAAYDKLEKTKNRLQQELDDLLVDLDHQRQLVSNLEKKQKKFDQMLAEEK 614
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   987 EIIAKLT------------KEKKALQEAHqqALDDLQaeeDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRK 1054
Cdd:pfam01576  615 AISARYAeerdraeaeareKETRALSLAR--ALEEAL---EAKEELERTNKQLRAEMEDLVSSKDDVGKNVHELERSKRA 689
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1055 LEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIE-DEQALGSQLQKKLKELQARIEELEEELEAERTARAKVE 1133
Cdd:pfam01576  690 LEQQVEEMKTQLEELEDELQATEDAKLRLEVNMQALKAQFErDLQARDEQGEEKRRQLVKQVRELEAELEDERKQRAQAV 769
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1134 KLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEA--------------------------TLQHEA 1187
Cdd:pfam01576  770 AAKKKLELDLKELEAQIDAANKGREEAVKQLKKLQAQMKDLQRELEEArasrdeilaqskesekklknleaellQLQEDL 849
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1188 TAAALRKKHADSVA-ELGEQIDN-------LQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEH 1259
Cdd:pfam01576  850 AASERARRQAQQERdELADEIASgasgksaLQDEKRRLEARIAQLEEELEEEQSNTELLNDRLRKSTLQVEQLTTELAAE 929
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1260 RSKAEETQrsvndltSQRAKLQTENGELSRQLDEKEALI-SQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARH 1338
Cdd:pfam01576  930 RSTSQKSE-------SARQQLERQNKELKAKLQEMEGTVkSKFKSSIAALEAKIAQLEEQLEQESRERQAANKLVRRTEK 1002
                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 124302198  1339 DCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYEtDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSL 1414
Cdd:pfam01576 1003 KLKEVLLQVEDERRHADQYKDQAEKGNSRMKQLKRQLE-EAEEEASRANAARRKLQRELDDATESNESMNREVSTL 1077
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
1053-1800 3.56e-14

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 78.14  E-value: 3.56e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1053 RKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKelqarieeleeeleaerTARAKV 1132
Cdd:TIGR04523   36 KQLEKKLKTIKNELKNKEKELKNLDKNLNKDEEKINNSNNKIKILEQQIKDLNDKLK-----------------KNKDKI 98
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1133 EKLRSDLSRELEEISERLEEaggatsvqieMNKKrEAEFQKMRRDLEEATLQHEATAAALRKKHADsVAELGEQIDNLQR 1212
Cdd:TIGR04523   99 NKLNSDLSKINSEIKNDKEQ----------KNKL-EVELNKLEKQKKENKKNIDKFLTEIKKKEKE-LEKLNNKYNDLKK 166
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1213 VKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSkaeetqrsvndLTSQRAKLQTENGELSRQLD 1292
Cdd:TIGR04523  167 QKEELENELNLLEKEKLNIQKNIDKIKNKLLKLELLLSNLKKKIQKNKS-----------LESQISELKKQNNQLKDNIE 235
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1293 EKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAknalahaLQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQ-W 1371
Cdd:TIGR04523  236 KKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQ-------LSEKQKELEQNNKKIKELEKQLNQLKSEISDLNNQKEQdW 308
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1372 RTKYETDAIQRTEELEEAKKKLAQrlqeAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDK 1451
Cdd:TIGR04523  309 NKELKSELKNQEKKLEEIQNQISQ----NNKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQ 384
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1452 ILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRK 1531
Cdd:TIGR04523  385 EIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRE 464
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1532 QLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAE---IERKLAEKDEEMEQAKRNhLRVVDSLQTSLDAETRSR 1608
Cdd:TIGR04523  465 SLETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEkkeLEEKVKDLTKKISSLKEK-IEKLESEKKEKESKISDL 543
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1609 NEALrVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEEL 1688
Cdd:TIGR04523  544 EDEL-NKDDFELKKENLEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEIEEKEKKISSLEKELEKA 622
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1689 RAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKA----KKAIT---- 1760
Cdd:TIGR04523  623 KKENEKLSSIIKNIKSKKNKLKQEVKQIKETIKEIRNKWPEIIKKIKESKTKIDDIIELMKDWLKELslhyKKYITrmir 702
                          730       740       750       760
                   ....*....|....*....|....*....|....*....|..
gi 124302198  1761 --DAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEA 1800
Cdd:TIGR04523  703 ikDLPKLEEKYKEIEKELKKLDEFSKELENIIKNFNKKFDDA 744
Myosin_N pfam02736
Myosin N-terminal SH3-like domain; This domain has an SH3-like fold. It is found at the ...
32-76 3.77e-14

Myosin N-terminal SH3-like domain; This domain has an SH3-like fold. It is found at the N-terminus of many but not all myosins. The function of this domain is unknown.


Pssm-ID: 460670  Cd Length: 45  Bit Score: 68.23  E-value: 3.77e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 124302198    32 DLKKDVFVPDDKQEFVKAKIVSREGGKVTAETEYGKTVTVKEDQV 76
Cdd:pfam02736    1 DAKKLVWVPDPKEGFVKGEIKEEEGDKVTVETEDGKTVTVKKDDV 45
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
901-1548 3.99e-14

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 78.18  E-value: 3.99e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  901 AEERCDQLIKNKIQ-LEAKVKEMNERLEDEEEMNAELtAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLT 979
Cdd:PRK03918  187 RTENIEELIKEKEKeLEEVLREINEISSELPELREEL-EKLEKEVKELEELKEEIEELEKELESLEGSKRKLEEKIRELE 265
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  980 EEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLtKAKVKLEQQVDDLE---GSLEQEKKVRMDLERAKRKLE 1056
Cdd:PRK03918  266 ERIEELKKEIEELEEKVKELKELKEKAEEYIKLSEFYEEYL-DELREIEKRLSRLEeeiNGIEERIKELEEKEERLEELK 344
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1057 GDLKLTQESIMDLENDKQQLDERLKKKDfELNALNARIEDEQAlgSQLQKKLKELQARIEELEEELEAERTARAKVEKLR 1136
Cdd:PRK03918  345 KKLKELEKRLEELEERHELYEEAKAKKE-ELERLKKRLTGLTP--EKLEKELEELEKAKEEIEEEISKITARIGELKKEI 421
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1137 SDLSRELEEiserLEEAGGATSVQiemnkKREAEFQKMRRDLEEATLQheataaalRKKHADSVAELGEQIDNLQRVKQK 1216
Cdd:PRK03918  422 KELKKAIEE----LKKAKGKCPVC-----GRELTEEHRKELLEEYTAE--------LKRIEKELKEIEEKERKLRKELRE 484
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1217 LEKeksefklelddVTSNMEQIIKAKANLEKMcRTLEDQMNEHR-SKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKE 1295
Cdd:PRK03918  485 LEK-----------VLKKESELIKLKELAEQL-KELEEKLKKYNlEELEKKAEEYEKLKEKLIKLKGEIKSLKKELEKLE 552
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1296 ALISQLTrgkltytqQLEDLKRQLEEEVKaknalahalqsarhdcDLLREQYEEETEAKAELQRvlskansevaqwrtky 1375
Cdd:PRK03918  553 ELKKKLA--------ELEKKLDELEEELA----------------ELLKELEELGFESVEELEE---------------- 592
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1376 etdaiqRTEELEEAKKKLaqrlqeaeeaVEAVNAkcsslEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAE 1455
Cdd:PRK03918  593 ------RLKELEPFYNEY----------LELKDA-----EKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEE 651
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1456 WKQKYeeSQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQ---EEISDLTEQLGSSGKTIHELEKVRKQ 1532
Cdd:PRK03918  652 LEKKY--SEEEYEELREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKeelEEREKAKKELEKLEKALERVEELREK 729
                         650
                  ....*....|....*..
gi 124302198 1533 LEAEKMEL-QSALEEAE 1548
Cdd:PRK03918  730 VKKYKALLkERALSKVG 746
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
843-1385 4.34e-14

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 78.18  E-value: 4.34e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  843 AEREKEMASMKEEFTRLKEaLEKSEARRKELEEKMVSLLQEKNDLQlqvqaeqdnladaeercdqliKNKIQLEAKVKEM 922
Cdd:PRK03918  269 EELKKEIEELEEKVKELKE-LKEKAEEYIKLSEFYEEYLDELREIE---------------------KRLSRLEEEINGI 326
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  923 NERLEDEEEMNAELtakkRKLEDECSELKRDIDDLEltlakvekEKHATENKVKNLTEEMAGLDEIIAKLTKEK--KALQ 1000
Cdd:PRK03918  327 EERIKELEEKEERL----EELKKKLKELEKRLEELE--------ERHELYEEAKAKKEELERLKKRLTGLTPEKleKELE 394
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1001 EAHQQALDdlqaEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGD-----LKLTQESIMDLENDKQQ 1075
Cdd:PRK03918  395 ELEKAKEE----IEEEISKITARIGELKKEIKELKKAIEELKKAKGKCPVCGRELTEEhrkelLEEYTAELKRIEKELKE 470
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1076 LDERLKKKDFELNALNARIEDEQALGSQLQ--KKLKELQARIEELEeeleaertarakVEKLRSDlSRELEEISERLEEA 1153
Cdd:PRK03918  471 IEEKERKLRKELRELEKVLKKESELIKLKElaEQLKELEEKLKKYN------------LEELEKK-AEEYEKLKEKLIKL 537
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1154 GGATSVqIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKhadsVAELG-EQIDNLQRVKQKLEKEKSEFkLELDDVT 1232
Cdd:PRK03918  538 KGEIKS-LKKELEKLEELKKKLAELEKKLDELEEELAELLKE----LEELGfESVEELEERLKELEPFYNEY-LELKDAE 611
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1233 SNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTS-----QRAKLQTENGELSRQLDEKEALISQLTRGKLT 1307
Cdd:PRK03918  612 KELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKkyseeEYEELREEYLELSRELAGLRAELEELEKRREE 691
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1308 YTQQLEDLKRQLEEEVKAKNALaHALQSARHDCDLLREQY-----EEETEAKAELQRVLSKANSEVAQwrTKYETDAIQR 1382
Cdd:PRK03918  692 IKKTLEKLKEELEEREKAKKEL-EKLEKALERVEELREKVkkykaLLKERALSKVGEIASEIFEELTE--GKYSGVRVKA 768

                  ...
gi 124302198 1383 TEE 1385
Cdd:PRK03918  769 EEN 771
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
1077-1923 7.88e-14

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 77.32  E-value: 7.88e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1077 DERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEEleaertARAKVEKLRSDLSRELEEISERLEEAGGA 1156
Cdd:pfam02463  152 PERRLEIEEEAAGSRLKRKKKEALKKLIEETENLAELIIDLEELK------LQELKLKEQAKKALEYYQLKEKLELEEEY 225
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1157 TSVQIEMnkKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNME 1236
Cdd:pfam02463  226 LLYLDYL--KLNEERIDLLQELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELL 303
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1237 Q-------IIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYT 1309
Cdd:pfam02463  304 KlerrkvdDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLES 383
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1310 QQLEDLKRQLEEEvkaknaLAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEA 1389
Cdd:pfam02463  384 ERLSSAAKLKEEE------LELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQE 457
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1390 KKKLAQRLQEAEEAVEAVNAKCsSLEKTKHRLQNEIEDLMVDVERSNAA---AAALDKKQRNFDKILAEWKQKYEESQSE 1466
Cdd:pfam02463  458 LKLLKDELELKKSEDLLKETQL-VKLQEQLELLLSRQKLEERSQKESKArsgLKVLLALIKDGVGGRIISAHGRLGDLGV 536
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1467 LESSQKEARSLST-ELFKLKNAYEESLEHLETFKRENKN----LQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQ 1541
Cdd:pfam02463  537 AVENYKVAISTAViVEVSATADEVEERQKLVRALTELPLgarkLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEAD 616
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1542 SALEEAEASLEHEEGKILraqlefnqiKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGD 1621
Cdd:pfam02463  617 EDDKRAKVVEGILKDTEL---------TKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAES 687
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1622 LNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIV---ERRNNLLQAELEELRAVVEQTERS 1698
Cdd:pfam02463  688 ELAKEEILRRQLEIKKKEQREKEELKKLKLEAEELLADRVQEAQDKINEELKLlkqKIDEEEEEEEKSRLKKEEKEEEKS 767
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1699 RKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKA----ITDAAMMAEELKKEQD 1774
Cdd:pfam02463  768 ELSLKEKELAEEREKTEKLKVEEEKEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEekikEEELEELALELKEEQK 847
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1775 TSAHLE---RMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELT 1851
Cdd:pfam02463  848 LEKLAEeelERLEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEA 927
                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 124302198  1852 YQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAK 1923
Cdd:pfam02463  928 EILLKYEEEPEELLLEEADEKEKEENNKEEEEERNKRLLLAKEELGKVNLMAIEEFEEKEERYNKDELEKER 999
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
843-1602 8.72e-14

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 77.32  E-value: 8.72e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   843 AEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEM 922
Cdd:pfam02463  275 KEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELEIKREAE 354
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   923 NERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEA 1002
Cdd:pfam02463  355 EEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEE 434
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1003 HQQALDDLQA--EEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERL 1080
Cdd:pfam02463  435 EEESIELKQGklTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARSGLKVLLA 514
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1081 KKKDFEL------------------NALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRE 1142
Cdd:pfam02463  515 LIKDGVGgriisahgrlgdlgvaveNYKVAISTAVIVEVSATADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSI 594
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1143 LEEISERL--EEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAElGEQIDNLQRVKQKLEKE 1220
Cdd:pfam02463  595 AVLEIDPIlnLAQLDKATLEADEDDKRAKVVEGILKDTELTKLKESAKAKESGLRKGVSLEE-GLAEKSEVKASLSELTK 673
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1221 KSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQ---LDEKEAL 1297
Cdd:pfam02463  674 ELLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEELKKLKLEAEELLADRVQEAQDKINEELKLLKQkidEEEEEEE 753
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1298 ISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDC----DLLREQYEEETEAKAELQRVLSKANSEVAQWRT 1373
Cdd:pfam02463  754 KSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEEEKEEKLkaqeEELRALEEELKEEAELLEEEQLLIEQEEKIKEE 833
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1374 KYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKiL 1453
Cdd:pfam02463  834 ELEELALELKEEQKLEKLAEEELERLEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNL-L 912
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1454 AEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLE-HLETFKRENKNLQEEISDLTEQLGSSgktIHELEKVRKQ 1532
Cdd:pfam02463  913 EEKENEIEERIKEEAEILLKYEEEPEELLLEEADEKEKEEnNKEEEEERNKRLLLAKEELGKVNLMA---IEEFEEKEER 989
                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1533 LEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLD 1602
Cdd:pfam02463  990 YNKDELEKERLEEEKKKLIRAIIEETCQRLKEFLELFVSINKGWNKVFFYLELGGSAELRLEDPDDPFSG 1059
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1381-1926 3.30e-13

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 75.10  E-value: 3.30e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1381 QRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKhrlqNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKy 1460
Cdd:PRK03918  200 KELEEVLREINEISSELPELREELEKLEKEVKELEELK----EEIEELEKELESLEGSKRKLEEKIRELEERIEELKKE- 274
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1461 eesqselESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVR---KQLEAEK 1537
Cdd:PRK03918  275 -------IEELEEKVKELKELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEerlEELKKKL 347
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1538 MELQSALEEAEASLE-HEEGKILRAQLEfnQIKAEIE----RKLAEKDEEMEQAK---RNHLRVVDSLQTSLDAETRSRN 1609
Cdd:PRK03918  348 KELEKRLEELEERHElYEEAKAKKEELE--RLKKRLTgltpEKLEKELEELEKAKeeiEEEISKITARIGELKKEIKELK 425
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1610 EALRVKKKMEGD--LNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLkENIAIVERRNNLLQAELEE 1687
Cdd:PRK03918  426 KAIEELKKAKGKcpVCGRELTEEHRKELLEEYTAELKRIEKELKEIEEKERKLRKELREL-EKVLKKESELIKLKELAEQ 504
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1688 LRAVVEQTErsrKLAEQELIETSERVQLLHSQNTslinqkkKMDADLSQLQTEVEEAvqecrNAEEKAKKAITDAAMMAE 1767
Cdd:PRK03918  505 LKELEEKLK---KYNLEELEKKAEEYEKLKEKLI-------KLKGEIKSLKKELEKL-----EELKKKLAELEKKLDELE 569
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1768 ELKKEQdtsahLERMKKNMEQTIKDLQHRLDEAEQ-----IALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRK 1842
Cdd:PRK03918  570 EELAEL-----LKELEELGFESVEELEERLKELEPfyneyLELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLEE 644
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1843 SERRIKELTYQ-TEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERAD---IAESQVN 1918
Cdd:PRK03918  645 LRKELEELEKKySEEEYEELREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEEREKAKKELEkleKALERVE 724

                  ....*...
gi 124302198 1919 KLRAKSRD 1926
Cdd:PRK03918  725 ELREKVKK 732
PTZ00121 PTZ00121
MAEBL; Provisional
1253-1925 4.07e-13

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 75.18  E-value: 4.07e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1253 EDQMNEHRSKAEETQRSVNDltsQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKrqLEEEVKAKNALAHA 1332
Cdd:PTZ00121 1050 EDIDGNHEGKAEAKAHVGQD---EGLKPSYKDFDFDAKEDNRADEATEEAFGKAEEAKKTETGK--AEEARKAEEAKKKA 1124
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1333 LQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKK----KLAQRLQEAEEAVEAVN 1408
Cdd:PTZ00121 1125 EDARKAEEARKAEDARKAEEARKAEDAKRVEIARKAEDARKAEEARKAEDAKKAEAARKaeevRKAEELRKAEDARKAEA 1204
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1409 AKCSSLEKT-----KHRLQNEIEDLM-VDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELF 1482
Cdd:PTZ00121 1205 ARKAEEERKaeearKAEDAKKAEAVKkAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELK 1284
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1483 KLknayEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQ 1562
Cdd:PTZ00121 1285 KA----EEKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAE 1360
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1563 LEFNQIKAEiERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAEtRSRNEALRVKKKMEgdlnemeiqlshANRMAAEAQKQ 1642
Cdd:PTZ00121 1361 AAEEKAEAA-EKKKEEAKKKADAAKKKAEEKKKADEAKKKAE-EDKKKADELKKAAA------------AKKKADEAKKK 1426
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1643 VKSLQSllKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTS 1722
Cdd:PTZ00121 1427 AEEKKK--ADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKK 1504
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1723 LINQKKKMDadlSQLQTEVEEAVQECRNAEEKAKkaiTDAAMMAEELKKEQDTSAhLERMKKNMEQTIKDLQHRLDEAEQ 1802
Cdd:PTZ00121 1505 AAEAKKKAD---EAKKAEEAKKADEAKKAEEAKK---ADEAKKAEEKKKADELKK-AEELKKAEEKKKAEEAKKAEEDKN 1577
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1803 IALKGGKKQLQKLEARVRELENELEAEQKRNAESVKgmRKSERRIK-ELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQ 1881
Cdd:PTZ00121 1578 MALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAK--KAEEAKIKaEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKA 1655
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....*...
gi 124302198 1882 AEE----AEEQANTNLSKFRKVQhELDEAEERADIAESQVNKLRAKSR 1925
Cdd:PTZ00121 1656 EEEnkikAAEEAKKAEEDKKKAE-EAKKAEEDEKKAAEALKKEAEEAK 1702
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
831-1327 5.13e-13

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 74.29  E-value: 5.13e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   831 KLYFKIKPLLKSA-EREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADaeercdqlI 909
Cdd:TIGR04523  121 KLEVELNKLEKQKkENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLEKEKLNIQKNIDK--------I 192
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   910 KNKI-QLEAKVKEMNERLEDEEEMNAELT---AKKRKLEDECSELKRDIDDLELTLAKVE-------------------- 965
Cdd:TIGR04523  193 KNKLlKLELLLSNLKKKIQKNKSLESQISelkKQNNQLKDNIEKKQQEINEKTTEISNTQtqlnqlkdeqnkikkqlsek 272
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   966 -KEKHATENKVKNLTEEMAGLDEIIAKLTKEKKalQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKV 1044
Cdd:TIGR04523  273 qKELEQNNKKIKELEKQLNQLKSEISDLNNQKE--QDWNKELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKE 350
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1045 RMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEA 1124
Cdd:TIGR04523  351 LTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIER 430
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1125 ERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAAL------RKKHAD 1198
Cdd:TIGR04523  431 LKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKELkklneeKKELEE 510
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1199 SVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNmeqIIKAKANLEKmcRTLEDQMNEHRSKAEETQRSVNDLTSQRA 1278
Cdd:TIGR04523  511 KVKDLTKKISSLKEKIEKLESEKKEKESKISDLEDE---LNKDDFELKK--ENLEKEIDEKNKEIEELKQTQKSLKKKQE 585
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*....
gi 124302198  1279 KLQTEngelsrqLDEKEALISQLTRGKLTYTQQLEDLKRQLeEEVKAKN 1327
Cdd:TIGR04523  586 EKQEL-------IDQKEKEKKDLIKEIEEKEKKISSLEKEL-EKAKKEN 626
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
843-1300 9.86e-13

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 73.54  E-value: 9.86e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  843 AEREKEMASMKEEFTRLKEAL---------------------EKSEARRKELEEKMVSLLQEKNDLQLQVQA-------E 894
Cdd:PRK02224  268 AETEREREELAEEVRDLRERLeeleeerddllaeaglddadaEAVEARREELEDRDEELRDRLEECRVAAQAhneeaesL 347
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  895 QDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENK 974
Cdd:PRK02224  348 REDADDLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELREERDELRER 427
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  975 VKNLTEEMAGLDEIIAkltkEKKALQEA--------------HQQALDDlqaEEDKVNTLTKAKVKLEQQVDDLEGSLEQ 1040
Cdd:PRK02224  428 EAELEATLRTARERVE----EAEALLEAgkcpecgqpvegspHVETIEE---DRERVEELEAELEDLEEEVEEVEERLER 500
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1041 EKKVRmDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEE 1120
Cdd:PRK02224  501 AEDLV-EAEDRIERLEERREDLEELIAERRETIEEKRERAEELRERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNS 579
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1121 ELEAERTARAKVEKLRSDLSrELEEISERLEEAGGATSVQIEMNKKRE---AEFQKMRRDLEEATLQHEATAAALRKKHA 1197
Cdd:PRK02224  580 KLAELKERIESLERIRTLLA-AIADAEDEIERLREKREALAELNDERRerlAEKRERKRELEAEFDEARIEEAREDKERA 658
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1198 DS-VAELGEQIDNLQRVKQKLEKEKSEFKLELDdvtsNMEQIIKAKANLEKMCRTLEDQMNEhrskAEETQRSVNDLtsq 1276
Cdd:PRK02224  659 EEyLEQVEEKLDELREERDDLQAEIGAVENELE----ELEELRERREALENRVEALEALYDE----AEELESMYGDL--- 727
                         490       500
                  ....*....|....*....|....*
gi 124302198 1277 RAKLQTEN-GELSRQLDEKEALISQ 1300
Cdd:PRK02224  728 RAELRQRNvETLERMLNETFDLVYQ 752
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
860-1209 1.48e-12

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 73.41  E-value: 1.48e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  860 KEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDnLADAEERCDQLIKNKI---QLEAKVKEMNERLEDEEEMNAEL 936
Cdd:COG4913   609 RAKLAALEAELAELEEELAEAEERLEALEAELDALQE-RREALQRLAEYSWDEIdvaSAEREIAELEAELERLDASSDDL 687
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  937 takkRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEmagLDEIIAKLTKEKKALQEAHQQALDDLQAEEDK 1016
Cdd:COG4913   688 ----AALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEE---LDELQDRLEAAEDLARLELRALLEERFAAALG 760
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1017 VNTLTKAKVKLEQQVDDLEGSLEQ-EKKVRMDLERAKRKLEGDLKLTQESIMDLEndkqqlderlkkkdfELNALNARIE 1095
Cdd:COG4913   761 DAVERELRENLEERIDALRARLNRaEEELERAMRAFNREWPAETADLDADLESLP---------------EYLALLDRLE 825
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1096 DEqalgsqlqkKLKELQARIEELEEeleaeRTARAKVEKLRSDLSRELEEISERLEEA---------GGATSVQIEMNKK 1166
Cdd:COG4913   826 ED---------GLPEYEERFKELLN-----ENSIEFVADLLSKLRRAIREIKERIDPLndslkripfGPGRYLRLEARPR 891
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 124302198 1167 REAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDN 1209
Cdd:COG4913   892 PDPEVREFRQELRAVTSGASLFDEELSEARFAALKRLIERLRS 934
PTZ00121 PTZ00121
MAEBL; Provisional
835-1511 1.59e-12

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 73.25  E-value: 1.59e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  835 KIKPLLKSAEREKEMAsmKEEFTRLKEALEKSEARRKELEEKmvsllqekndlqlqvqaeqdnladaeercdqliKNKIQ 914
Cdd:PTZ00121 1316 KADEAKKKAEEAKKKA--DAAKKKAEEAKKAAEAAKAEAEAA---------------------------------ADEAE 1360
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  915 LEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRdiddleltlaKVEKEKHATEnKVKNLTEEMAGLDEIIAKLTK 994
Cdd:PTZ00121 1361 AAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKK----------KAEEDKKKAD-ELKKAAAAKKKADEAKKKAEE 1429
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  995 EKKAlQEAHQQALDDLQAEEdkvntlTKAKVKLEQQVDDLEGSLEQEKKVrmdlERAKRKLEgDLKLTQESIMDLENDKQ 1074
Cdd:PTZ00121 1430 KKKA-DEAKKKAEEAKKADE------AKKKAEEAKKAEEAKKKAEEAKKA----DEAKKKAE-EAKKADEAKKKAEEAKK 1497
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1075 QLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQArieeleeeleaeRTARAKVEKLRSDLSRELEEISERLEEAg 1154
Cdd:PTZ00121 1498 KADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKA------------DEAKKAEEKKKADELKKAEELKKAEEKK- 1564
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1155 gatsvQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEfklelDDVTSN 1234
Cdd:PTZ00121 1565 -----KAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKA-----EEEKKK 1634
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1235 MEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRsvndltsqRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLED 1314
Cdd:PTZ00121 1635 VEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAK--------KAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEE 1706
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1315 LKRQLEEEVKAKNALAHALQSARHDCDLLREQyEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEEL-----EEA 1389
Cdd:PTZ00121 1707 LKKKEAEEKKKAEELKKAEEENKIKAEEAKKE-AEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKeavieEEL 1785
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1390 KKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKilAEWKQKYEESQSELES 1469
Cdd:PTZ00121 1786 DEEDEKRRMEVDKKIKDIFDNFANIIEGGKEGNLVINDSKEMEDSAIKEVADSKNMQLEEAD--AFEKHKFNKNNENGED 1863
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|..
gi 124302198 1470 SQKEARSlSTELFKLKNAYEESLEHLETFKRENKNLQEEISD 1511
Cdd:PTZ00121 1864 GNKEADF-NKEKDLKEDDEEEIEEADEIEKIDKDDIEREIPN 1904
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
1037-1926 1.64e-12

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 73.16  E-value: 1.64e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1037 SLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFElNALNARIEDEQALGSQLQKKLKELQARIE 1116
Cdd:TIGR00606  187 ALETLRQVRQTQGQKVQEHQMELKYLKQYKEKACEIRDQITSKEAQLESS-REIVKSYENELDPLKNRLKEIEHNLSKIM 265
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1117 ELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGatsvQIEMNKKREA-EFQKMRRDLEEATLQHEATAAALRKK 1195
Cdd:TIGR00606  266 KLDNEIKALKSRKKQMEKDNSELELKMEKVFQGTDEQLN----DLYHNHQRTVrEKERELVDCQRELEKLNKERRLLNQE 341
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1196 HADSVAELGE-----QIDNLQRVKQKLEKEKSEFKLELD------DVTSNMEQIIK-AKANLEKMCRTLEDQMNEHRSKA 1263
Cdd:TIGR00606  342 KTELLVEQGRlqlqaDRHQEHIRARDSLIQSLATRLELDgfergpFSERQIKNFHTlVIERQEDEAKTAAQLCADLQSKE 421
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1264 EETQRSVNDLTSQRAKL----QTENGELSRQLDEKEALISQLTRGkltyTQQLEDLKRQLEEEVKAKNALAHALQSARHD 1339
Cdd:TIGR00606  422 RLKQEQADEIRDEKKGLgrtiELKKEILEKKQEELKFVIKELQQL----EGSSDRILELDQELRKAERELSKAEKNSLTE 497
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1340 CDLLREQYEEETeaKAELQRVLSKANSEVAQwrTKYETDAIQRTEELEEAKKKLAQRL-----QEAEEAVEAVN--AKCS 1412
Cdd:TIGR00606  498 TLKKEVKSLQNE--KADLDRKLRKLDQEMEQ--LNHHTTTRTQMEMLTKDKMDKDEQIrkiksRHSDELTSLLGyfPNKK 573
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1413 SLEKTKHRLQNEI---EDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEES-------------QSELESSQKEARS 1476
Cdd:TIGR00606  574 QLEDWLHSKSKEInqtRDRLAKLNKELASLEQNKNHINNELESKEEQLSSYEDKlfdvcgsqdeesdLERLKEEIEKSSK 653
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1477 LSTELFKLKNAYEESLEHLET------------FKREnKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSAL 1544
Cdd:TIGR00606  654 QRAMLAGATAVYSQFITQLTDenqsccpvcqrvFQTE-AELQEFISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLA 732
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1545 EEAEASLEHEEGKILRAQLEFNQIKAEIERKLA--EKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDL 1622
Cdd:TIGR00606  733 PGRQSIIDLKEKEIPELRNKLQKVNRDIQRLKNdiEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQA 812
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1623 NEMEiqlshanrmAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRA----VVEQTERS 1698
Cdd:TIGR00606  813 AKLQ---------GSDLDRTVQQVNQEKQEKQHELDTVVSKIELNRKLIQDQQEQIQHLKSKTNELKSeklqIGTNLQRR 883
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1699 RKLAEQeLIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQecrNAEEKAKKAITDAAMMAEELKK------- 1771
Cdd:TIGR00606  884 QQFEEQ-LVELSTEVQSLIREIKDAKEQDSPLETFLEKDQQEKEELIS---SKETSNKKAQDKVNDIKEKVKNihgymkd 959
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1772 -EQDTSAHLERMKKNMEQTIKDLQHRLDEAEQialkggkkQLQKLEARVRELENELEAE--QKRNAESVKGMRKSERRIK 1848
Cdd:TIGR00606  960 iENKIQDGKDDYLKQKETELNTVNAQLEECEK--------HQEKINEDMRLMRQDIDTQkiQERWLQDNLTLRKRENELK 1031
                          890       900       910       920       930       940       950
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 124302198  1849 ELtyqtEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRD 1926
Cdd:TIGR00606 1032 EV----EEELKQHLKEMGQMQVLQMKQEHQKLEENIDLIKRNHVLALGRQKGYEKEIKHFKKELREPQFRDAEEKYRE 1105
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1487-1924 2.30e-12

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 72.38  E-value: 2.30e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1487 AYEESLEHLETfkrenknLQEEISDLTEqlgssgkTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFN 1566
Cdd:PRK02224  245 EHEERREELET-------LEAEIEDLRE-------TIAETEREREELAEEVRDLRERLEELEEERDDLLAEAGLDDADAE 310
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1567 QIKAEIErKLAEKDEEMEQAKRNHLrvVDSLQTSLDAET--------RSRNEALRVK-KKMEGDLNEMEIQLSHANRMAA 1637
Cdd:PRK02224  311 AVEARRE-ELEDRDEELRDRLEECR--VAAQAHNEEAESlredaddlEERAEELREEaAELESELEEAREAVEDRREEIE 387
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1638 EAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSR---KLAE--QElIETSER 1712
Cdd:PRK02224  388 ELEEEIEELRERFGDAPVDLGNAEDFLEELREERDELREREAELEATLRTARERVEEAEALLeagKCPEcgQP-VEGSPH 466
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1713 VQLLHSQNtsliNQKKKMDADLSQLQTEVEEAvqecrnaEEKAKKAitdaammaEELKKEQDTSAHLERMKKNMEQTIKD 1792
Cdd:PRK02224  467 VETIEEDR----ERVEELEAELEDLEEEVEEV-------EERLERA--------EDLVEAEDRIERLEERREDLEELIAE 527
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1793 LQHRLDEAEQialkggkkQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEE---DRKNLLRLQDLVD 1869
Cdd:PRK02224  528 RRETIEEKRE--------RAEELRERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAElkeRIESLERIRTLLA 599
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 124302198 1870 KLQLKVKAYKRQAEEAEEQANTN------LSKFRKVQHELDEAEERADIAESQVNKLRAKS 1924
Cdd:PRK02224  600 AIADAEDEIERLREKREALAELNderrerLAEKRERKRELEAEFDEARIEEAREDKERAEE 660
HOOK pfam05622
HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from ...
1488-1828 5.05e-12

HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organizms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas this central coiled-coil motif mediates homodimerization and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localized to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head. This entry includes the central coiled-coiled domain and the divergent C-terminal domain.


Pssm-ID: 461694 [Multi-domain]  Cd Length: 528  Bit Score: 70.87  E-value: 5.05e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1488 YEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQsaleEAEASLEHEEGKILRAQLEFNQ 1567
Cdd:pfam05622  140 YKKKLEDLGDLRRQVKLLEERNAEYMQRTLQLEEELKKANALRGQLETYKRQVQ----ELHGKLSEESKKADKLEFEYKK 215
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1568 IKA-------EIERKLAEKD---EEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAA 1637
Cdd:pfam05622  216 LEEklealqkEKERLIIERDtlrETNEELRCAQLQQAELSQADALLSPSSDPGDNLAAEIMPAEIREKLIRLQHENKMLR 295
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1638 EAQKQvkSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRavveqtersRKLAEQElietservqllh 1717
Cdd:pfam05622  296 LGQEG--SYRERLTELQQLLEDANRRKNELETQNRLANQRILELQQQVEELQ---------KALQEQG------------ 352
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1718 SQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEEL-----KKEQDTSAHLERMKKNMEQ---T 1789
Cdd:pfam05622  353 SKAEDSSLLKQKLEEHLEKLHEAQSELQKKKEQIEELEPKQDSNLAQKIDELqealrKKDEDMKAMEERYKKYVEKaksV 432
                          330       340       350
                   ....*....|....*....|....*....|....*....
gi 124302198  1790 IKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEA 1828
Cdd:pfam05622  433 IKTLDPKQNPASPPEIQALKNQLLEKDKKIEHLERDFEK 471
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
830-1599 7.61e-12

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 70.77  E-value: 7.61e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   830 MKLYFKIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLI 909
Cdd:pfam02463  232 LKLNEERIDLLQELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVD 311
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   910 KNKIQ-------------LEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVK 976
Cdd:pfam02463  312 DEEKLkesekekkkaekeLKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAK 391
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   977 NLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLE 1056
Cdd:pfam02463  392 LKEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSE 471
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1057 GDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLqKKLKELQARIEELEEELEAERTARAKVEKLR 1136
Cdd:pfam02463  472 DLLKETQLVKLQEQLELLLSRQKLEERSQKESKARSGLKVLLALIKDG-VGGRIISAHGRLGDLGVAVENYKVAISTAVI 550
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1137 SDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQK 1216
Cdd:pfam02463  551 VEVSATADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRAKVVEGILK 630
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1217 LEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRqldeKEA 1296
Cdd:pfam02463  631 DTELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKK----KEQ 706
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1297 LISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYE 1376
Cdd:pfam02463  707 REKEELKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKL 786
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1377 TDAIQRTE-----ELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVErsnaAAAALDKKQRNFDK 1451
Cdd:pfam02463  787 KVEEEKEEklkaqEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKL----EKLAEEELERLEEE 862
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1452 ILAEWK------QKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHE 1525
Cdd:pfam02463  863 ITKEELlqelllKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEILLKYEEEPEELLL 942
                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 124302198  1526 LEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQT 1599
Cdd:pfam02463  943 EEADEKEKEENNKEEEEERNKRLLLAKEELGKVNLMAIEEFEEKEERYNKDELEKERLEEEKKKLIRAIIEETC 1016
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
840-1255 1.14e-11

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 69.80  E-value: 1.14e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  840 LKSAERE-KEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQD--NLADAEERCDQLIKNKIQLE 916
Cdd:COG4717    73 LKELEEElKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLLPLyqELEALEAELAELPERLEELE 152
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  917 AKVKEMNERLEDEEEMNAELTAKKRKLEDEC-----------SELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGL 985
Cdd:COG4717   153 ERLEELRELEEELEELEAELAELQEELEELLeqlslateeelQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQL 232
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  986 DEIIAKLTKEKKALQE-----------AHQQALDDLQAEEDKV---------------NTLTKAKVKLEQQVDDLEGSLE 1039
Cdd:COG4717   233 ENELEAAALEERLKEArlllliaaallALLGLGGSLLSLILTIagvlflvlgllallfLLLAREKASLGKEAEELQALPA 312
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1040 QEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKkdfelnalnARIEDEQALGSQLQKKLKELQARIEELE 1119
Cdd:COG4717   313 LEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLRE---------AEELEEELQLEELEQEIAALLAEAGVED 383
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1120 EELEAertARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKR--EAEFQKMRRDLEEATLQHEataaALRKKHA 1197
Cdd:COG4717   384 EEELR---AALEQAEEYQELKEELEELEEQLEELLGELEELLEALDEEelEEELEELEEELEELEEELE----ELREELA 456
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1198 DSVAELG--EQIDNLQRVKQKLEKEKSEFKLELDDVTSNMeqiiKAKANLEKMCRTLEDQ 1255
Cdd:COG4717   457 ELEAELEqlEEDGELAELLQELEELKAELRELAEEWAALK----LALELLEEAREEYREE 512
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1473-1918 1.87e-11

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 69.56  E-value: 1.87e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1473 EARSLSTELFKLKNAYEESLEhletfKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEasLE 1552
Cdd:COG4913   226 AADALVEHFDDLERAHEALED-----AREQIELLEPIRELAERYAAARERLAELEYLRAALRLWFAQRRLELLEAE--LE 298
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1553 HEEGKILRAQLEFNQIKAEIERkLAEKDEEMEQAKRNH-LRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSH 1631
Cdd:COG4913   299 ELRAELARLEAELERLEARLDA-LREELDELEAQIRGNgGDRLEQLEREIERLERELEERERRRARLEALLAALGLPLPA 377
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1632 A----NRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKEN-------IAIVERRNNLLQAELEELRAVVEqteRSRK 1700
Cdd:COG4913   378 SaeefAALRAEAAALLEALEEELEALEEALAEAEAALRDLRRElreleaeIASLERRKSNIPARLLALRDALA---EALG 454
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1701 LAEQ------ELIETS----------ERVqlLHSQNTSL-------------INQKK----------------------- 1728
Cdd:COG4913   455 LDEAelpfvgELIEVRpeeerwrgaiERV--LGGFALTLlvppehyaaalrwVNRLHlrgrlvyervrtglpdperprld 532
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1729 ------KMDADLSQLQTEVEEAVQE------CRNAEE--KAKKAITDAAMMAEELKK-EQDTSAHLER---MKKNMEQTI 1790
Cdd:COG4913   533 pdslagKLDFKPHPFRAWLEAELGRrfdyvcVDSPEElrRHPRAITRAGQVKGNGTRhEKDDRRRIRSryvLGFDNRAKL 612
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1791 KDLQHRLDEAEQiALKGGKKQLQKLEARVRELENELEAEQK--RNAESVKGMRKSERRIKELtyqtEEDRKNLLRLQDLV 1868
Cdd:COG4913   613 AALEAELAELEE-ELAEAEERLEALEAELDALQERREALQRlaEYSWDEIDVASAEREIAEL----EAELERLDASSDDL 687
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|
gi 124302198 1869 DKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVN 1918
Cdd:COG4913   688 AALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLE 737
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
914-1858 2.71e-11

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 69.31  E-value: 2.71e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   914 QLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKekhatenkvknLTEEMAGLDEIIAKLT 993
Cdd:TIGR00606  214 QYKEKACEIRDQITSKEAQLESSREIVKSYENELDPLKNRLKEIEHNLSKIMK-----------LDNEIKALKSRKKQME 282
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   994 KEKKALQEAHQQALDDLQAEEDKVNTLTKAKVK-LEQQVDDLEGSLEQEKKVRMDLERAKRKLEgdlklTQESIMDLEND 1072
Cdd:TIGR00606  283 KDNSELELKMEKVFQGTDEQLNDLYHNHQRTVReKERELVDCQRELEKLNKERRLLNQEKTELL-----VEQGRLQLQAD 357
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1073 KQQldERLKKKDFELNALNARIE-DEQALGSQLQKKLKelQARIEELEEELEAERTARAKVEKLRSDLS---RELEEISE 1148
Cdd:TIGR00606  358 RHQ--EHIRARDSLIQSLATRLElDGFERGPFSERQIK--NFHTLVIERQEDEAKTAAQLCADLQSKERlkqEQADEIRD 433
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1149 RLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHE---ATAAALRKKHAD-SVAELGEQIDNLQRVKQKLEKEKSEF 1224
Cdd:TIGR00606  434 EKKGLGRTIELKKEILEKKQEELKFVIKELQQLEGSSDrilELDQELRKAERElSKAEKNSLTETLKKEVKSLQNEKADL 513
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1225 KLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQraklqtengelsrqldekealisqltRG 1304
Cdd:TIGR00606  514 DRKLRKLDQEMEQLNHHTTTRTQMEMLTKDKMDKDEQIRKIKSRHSDELTSL--------------------------LG 567
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1305 KLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTkYETDAIQRTE 1384
Cdd:TIGR00606  568 YFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASLEQNKNHINNELESKEEQLSSYEDKLFDVCGSQD-EESDLERLKE 646
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1385 ELEEAKKKLA----------QRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDL----MVDVERSNAAAAALDKKQRNFD 1450
Cdd:TIGR00606  647 EIEKSSKQRAmlagatavysQFITQLTDENQSCCPVCQRVFQTEAELQEFISDLqsklRLAPDKLKSTESELKKKEKRRD 726
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1451 KIL--AEWKQKYEESQSELESSQKEA-RSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLT--EQLgssgktIHE 1525
Cdd:TIGR00606  727 EMLglAPGRQSIIDLKEKEIPELRNKlQKVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTimERF------QME 800
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1526 LEKVRKQLEAEKMELQSAleEAEASLEHEEGKILRAQLEFNQIKAEIErkLAEKDEEMEQAKRNHLRvvdSLQTSLDAET 1605
Cdd:TIGR00606  801 LKDVERKIAQQAAKLQGS--DLDRTVQQVNQEKQEKQHELDTVVSKIE--LNRKLIQDQQEQIQHLK---SKTNELKSEK 873
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1606 RSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANddlkeniaivERRNNLLQAEL 1685
Cdd:TIGR00606  874 LQIGTNLQRRQQFEEQLVELSTEVQSLIREIKDAKEQDSPLETFLEKDQQEKEELISSK----------ETSNKKAQDKV 943
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1686 EELRAVVEQTERSRKLAEQELIETSERvqllhsqntslinQKKKMDADLSQLQTEVEEAVQECRNAEE--KAKKAITDAA 1763
Cdd:TIGR00606  944 NDIKEKVKNIHGYMKDIENKIQDGKDD-------------YLKQKETELNTVNAQLEECEKHQEKINEdmRLMRQDIDTQ 1010
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1764 MMAEELKKEQDTSAHLERMKKNMEQTIKdlQHrLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKS 1843
Cdd:TIGR00606 1011 KIQERWLQDNLTLRKRENELKEVEEELK--QH-LKEMGQMQVLQMKQEHQKLEENIDLIKRNHVLALGRQKGYEKEIKHF 1087
                          970
                   ....*....|....*
gi 124302198  1844 ERRIKELTYQTEEDR 1858
Cdd:TIGR00606 1088 KKELREPQFRDAEEK 1102
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1310-1847 3.01e-11

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 68.79  E-value: 3.01e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1310 QQLEDLKRQLEEEVKAKNALAHALQSArhdcdllrEQYEEETEAKAELQRVLSKANSEVAQwrTKYETdAIQRTEELEEA 1389
Cdd:COG4913   235 DDLERAHEALEDAREQIELLEPIRELA--------ERYAAARERLAELEYLRAALRLWFAQ--RRLEL-LEAELEELRAE 303
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1390 KKKLAQRLQEAEEAVEAVNAKCSSLE--------KTKHRLQNEIEDLMVDVERSNAAAAALDKKQRN-----------FD 1450
Cdd:COG4913   304 LARLEAELERLEARLDALREELDELEaqirgnggDRLEQLEREIERLERELEERERRRARLEALLAAlglplpasaeeFA 383
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1451 KILAEWKQkyeesqselessqkEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEIsdltEQLGSSGKTI-HELEKV 1529
Cdd:COG4913   384 ALRAEAAA--------------LLEALEEELEALEEALAEAEAALRDLRRELRELEAEI----ASLERRKSNIpARLLAL 445
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1530 RKQLE-------------AEKMEL-------QSALEEA---------------EASLEHEEGKILRAQLEFNQIKAeier 1574
Cdd:COG4913   446 RDALAealgldeaelpfvGELIEVrpeeerwRGAIERVlggfaltllvppehyAAALRWVNRLHLRGRLVYERVRT---- 521
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1575 klAEKDEEMEQAKRNHL-RVVDS----LQTSLDAETRSRNEALRVkkkmegdlnEMEIQLSHAnRMAAEAQKQVKSLQSL 1649
Cdd:COG4913   522 --GLPDPERPRLDPDSLaGKLDFkphpFRAWLEAELGRRFDYVCV---------DSPEELRRH-PRAITRAGQVKGNGTR 589
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1650 L-KDTQIQLD-------DAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAE--QELIETSERVQLLHSQ 1719
Cdd:COG4913   590 HeKDDRRRIRsryvlgfDNRAKLAALEAELAELEEELAEAEERLEALEAELDALQERREALQrlAEYSWDEIDVASAERE 669
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1720 NTSLINQKKKMDA---DLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELkkeqdtsahlermkKNMEQTIKDLQHR 1796
Cdd:COG4913   670 IAELEAELERLDAssdDLAALEEQLEELEAELEELEEELDELKGEIGRLEKEL--------------EQAEEELDELQDR 735
                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 124302198 1797 LDEAEQIALKGGKKQLQKL------EARVRELENELEAEQKRNAESvkgMRKSERRI 1847
Cdd:COG4913   736 LEAAEDLARLELRALLEERfaaalgDAVERELRENLEERIDALRAR---LNRAEEEL 789
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
851-1405 3.08e-11

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 68.79  E-value: 3.08e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  851 SMKEEFTRLKEA---LEKSEARRKELE------EKMVSLLQEKNDLQ-----LQVQAEQDNLADAEERCDQLIKNKIQLE 916
Cdd:COG4913   229 ALVEHFDDLERAheaLEDAREQIELLEpirelaERYAAARERLAELEylraaLRLWFAQRRLELLEAELEELRAELARLE 308
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  917 AKVKEMNERLEDEEEMNAELTAKKRKLE-DECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKE 995
Cdd:COG4913   309 AELERLEARLDALREELDELEAQIRGNGgDRLEQLEREIERLERELEERERRRARLEALLAALGLPLPASAEEFAALRAE 388
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  996 KKALQEAHQQALDDLQAEEDKvntLTKAKVKLEQQVDDLEG---SLEQeKKVRMD--LERAKRKLEGDLKLTQESIM--- 1067
Cdd:COG4913   389 AAALLEALEEELEALEEALAE---AEAALRDLRRELRELEAeiaSLER-RKSNIParLLALRDALAEALGLDEAELPfvg 464
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1068 DLendkqqLDERLKKKDFElNALnariedEQALGSQ----L--QKKLKE---------LQARIEELEEELEAERTARAK- 1131
Cdd:COG4913   465 EL------IEVRPEEERWR-GAI------ERVLGGFaltlLvpPEHYAAalrwvnrlhLRGRLVYERVRTGLPDPERPRl 531
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1132 -----VEKLRSDLSRELEEISERLEEAGGATSVQiemnkkREAEFQKMRRDL-EEATLQHEATAAALRKKHA-DSVAELG 1204
Cdd:COG4913   532 dpdslAGKLDFKPHPFRAWLEAELGRRFDYVCVD------SPEELRRHPRAItRAGQVKGNGTRHEKDDRRRiRSRYVLG 605
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1205 EqiDNLQRVKQkLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLE--DQMNEHRSKAEETQRSVNDLTSQRAKLQT 1282
Cdd:COG4913   606 F--DNRAKLAA-LEAELAELEEELAEAEERLEALEAELDALQERREALQrlAEYSWDEIDVASAEREIAELEAELERLDA 682
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1283 ENGELSRQLDEKEALisqltrgkltyTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRvls 1362
Cdd:COG4913   683 SSDDLAALEEQLEEL-----------EAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELR--- 748
                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....*
gi 124302198 1363 kanSEVAQWRTKYETDAIQRT--EELEEAKKKLAQRLQEAEEAVE 1405
Cdd:COG4913   749 ---ALLEERFAAALGDAVERElrENLEERIDALRARLNRAEEELE 790
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
861-1658 4.18e-11

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 68.46  E-value: 4.18e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   861 EALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDnlaDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAK- 939
Cdd:TIGR00618  173 FPLDQYTQLALMEFAKKKSLHGKAELLTLRSQLLTL---CTPCMPDTYHERKQVLEKELKHLREALQQTQQSHAYLTQKr 249
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   940 -----KRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKnlteemagldeiIAKLTKEKKALQEAHQQALDDLQAEE 1014
Cdd:TIGR00618  250 eaqeeQLKKQQLLKQLRARIEELRAQEAVLEETQERINRARK------------AAPLAAHIKAVTQIEQQAQRIHTELQ 317
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1015 DKVNTLTKAKVKLEQQVDDlEGSLEQEKKVRMDLERAKRKLEgDLKLTQESIMDLENDKQQLDERLKKKDFELNALnari 1094
Cdd:TIGR00618  318 SKMRSRAKLLMKRAAHVKQ-QSSIEEQRRLLQTLHSQEIHIR-DAHEVATSIREISCQQHTLTQHIHTLQQQKTTL---- 391
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1095 EDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKlrsdlSRELEEISERLEEAGGATSVQIEmnKKREAEFQKM 1174
Cdd:TIGR00618  392 TQKLQSLCKELDILQREQATIDTRTSAFRDLQGQLAHAKK-----QQELQQRYAELCAAAITCTAQCE--KLEKIHLQES 464
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1175 RRDLEEATlQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVtsnmeqiikakANLEKMCRTLED 1254
Cdd:TIGR00618  465 AQSLKERE-QQLQTKEQIHLQETRKKAVVLARLLELQEEPCPLCGSCIHPNPARQDI-----------DNPGPLTRRMQR 532
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1255 QMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRgkltYTQQLEDLkRQLEEEVKaknalahalq 1334
Cdd:TIGR00618  533 GEQTYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNR----SKEDIPNL-QNITVRLQ---------- 597
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1335 sarhdcDLLREQYEEETEAKAELQRVLSKANSEVAqwrtKYETDAIQRTEELEEAKKKLAqrlqeaeeaveavnakcssl 1414
Cdd:TIGR00618  598 ------DLTEKLSEAEDMLACEQHALLRKLQPEQD----LQDVRLHLQQCSQELALKLTA-------------------- 647
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1415 ektkhrLQNEIEDLMVDVERSNAAAAALDKKQRnfdkilaewkqkyeesqselessqkeARSLSTELFKLKNAYEESLEH 1494
Cdd:TIGR00618  648 ------LHALQLTLTQERVREHALSIRVLPKEL--------------------------LASRQLALQKMQSEKEQLTYW 695
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1495 LETFKRENKNLQEEIsdltEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIER 1574
Cdd:TIGR00618  696 KEMLAQCQTLLRELE----THIEEYDREFNEIENASSSLGSDLAAREDALNQSLKELMHQARTVLKARTEAHFNNNEEVT 771
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1575 KLAEKDEEMEQAKRNHLRVVDSLQTSLdAETRSRNEALRVKKKMEGDLNEMEIQLshanrmAAEAQKQVKSLQSLLKDTQ 1654
Cdd:TIGR00618  772 AALQTGAELSHLAAEIQFFNRLREEDT-HLLKTLEAEIGQEIPSDEDILNLQCET------LVQEEEQFLSRLEEKSATL 844

                   ....
gi 124302198  1655 IQLD 1658
Cdd:TIGR00618  845 GEIT 848
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
901-1140 4.43e-11

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 67.10  E-value: 4.43e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  901 AEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTE 980
Cdd:COG4942    18 QADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRA 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  981 EMAGLDEIIAKLTKekkALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLK 1060
Cdd:COG4942    98 ELEAQKEELAELLR---ALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERA 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1061 LTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIE--ELEEELEAERTARAKVEKLRSD 1138
Cdd:COG4942   175 ELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIArlEAEAAAAAERTPAAGFAALKGK 254

                  ..
gi 124302198 1139 LS 1140
Cdd:COG4942   255 LP 256
mukB PRK04863
chromosome partition protein MukB;
847-1695 7.90e-11

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 67.67  E-value: 7.90e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  847 KEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQliKNKIQ--------LEAK 918
Cdd:PRK04863  286 EEALELRRELYTSRRQLAAEQYRLVEMARELAELNEAESDLEQDYQAASDHLNLVQTALRQ--QEKIEryqadleeLEER 363
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  919 VKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDL-------------------------------ELTLAKVEKE 967
Cdd:PRK04863  364 LEEQNEVVEEADEQQEENEARAEAAEEEVDELKSQLADYqqaldvqqtraiqyqqavqalerakqlcglpDLTADNAEDW 443
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  968 KHATENKVKNLTEEMAGL-------DEIIAKLTKEKKALQ---------EAHQQALDDL-QAEEDKVntLTKAKVKLEQQ 1030
Cdd:PRK04863  444 LEEFQAKEQEATEELLSLeqklsvaQAAHSQFEQAYQLVRkiagevsrsEAWDVARELLrRLREQRH--LAEQLQQLRMR 521
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1031 VDDLEGSLEQEKkvrmDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKkkdfelnALNARIEDEQALGSQLQKKLKE 1110
Cdd:PRK04863  522 LSELEQRLRQQQ----RAERLLAEFCKRLGKNLDDEDELEQLQEELEARLE-------SLSESVSEARERRMALRQQLEQ 590
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1111 LQARIEELEEELEAERTARAKVEKLRSDLSRELEEiSERLEEAggatsvqiemnkkreaeFQKMRRDLEEATLQHEATAA 1190
Cdd:PRK04863  591 LQARIQRLAARAPAWLAAQDALARLREQSGEEFED-SQDVTEY-----------------MQQLLERERELTVERDELAA 652
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1191 ALRkkhadsvaELGEQIDNLQ--------RVKQKLEKEKSEFKLEL-DDVTSN------------MEQII-----KAKAN 1244
Cdd:PRK04863  653 RKQ--------ALDEEIERLSqpggsedpRLNALAERFGGVLLSEIyDDVSLEdapyfsalygpaRHAIVvpdlsDAAEQ 724
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1245 LEKMCRTLED---------QMNEHRSKAEETQRSVNDLTSQRAklqtengelSRqldekealISQLTR----GKLTYTQQ 1311
Cdd:PRK04863  725 LAGLEDCPEDlyliegdpdSFDDSVFSVEELEKAVVVKIADRQ---------WR--------YSRFPEvplfGRAAREKR 787
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1312 LEDLKRQLEEEVkaknalahalqsarhdcdllrEQYEEETEAKAELQRVLSKANSEVA-------QWRTKYETDAIQRT- 1383
Cdd:PRK04863  788 IEQLRAEREELA---------------------ERYATLSFDVQKLQRLHQAFSRFIGshlavafEADPEAELRQLNRRr 846
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1384 -------EELEEAKKKLAQRLQEAEEAVEAVN--AKCSSLEKTKHrLQNEIEDLMVDVERSNAAAAALDKKQRNFDKI-- 1452
Cdd:PRK04863  847 veleralADHESQEQQQRSQLEQAKEGLSALNrlLPRLNLLADET-LADRVEEIREQLDEAEEAKRFVQQHGNALAQLep 925
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1453 -----------LAEWKQKYEESQSELESSQKEARSLsTELFKLKN--AYEESLEHLetfkrenknlqEEISDLTEQLgss 1519
Cdd:PRK04863  926 ivsvlqsdpeqFEQLKQDYQQAQQTQRDAKQQAFAL-TEVVQRRAhfSYEDAAEML-----------AKNSDLNEKL--- 990
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1520 gktiheleKVR-KQLEAEKMELQSALEEAEAslEHEEGKILRAQLE-----FNQIKAEIERKLAE----KDEEMEQAKRN 1589
Cdd:PRK04863  991 --------RQRlEQAEQERTRAREQLRQAQA--QLAQYNQVLASLKssydaKRQMLQELKQELQDlgvpADSGAEERARA 1060
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1590 HLrvvDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQV----KSLQSLLKdtqiqlddAVRAND 1665
Cdd:PRK04863 1061 RR---DELHARLSANRSRRNQLEKQLTFCEAEMDNLTKKLRKLERDYHEMREQVvnakAGWCAVLR--------LVKDNG 1129
                         970       980       990
                  ....*....|....*....|....*....|....*
gi 124302198 1666 dlkeniaiVERRnnLLQAEL-----EELRAVVEQT 1695
Cdd:PRK04863 1130 --------VERR--LHRRELaylsaDELRSMSDKA 1154
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
1078-1753 8.71e-11

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 67.05  E-value: 8.71e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1078 ERLKKKDFELNALNARIEDEQALGSQLQKKLK-ELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGA 1156
Cdd:pfam05483   63 EGLKDSDFENSEGLSRLYSKLYKEAEKIKKWKvSIEAELKQKENKLQENRKIIEAQRKAIQELQFENEKVSLKLEEEIQE 142
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1157 TSVQIEMNKKREAEFQKMRRDLE---EATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDvts 1233
Cdd:pfam05483  143 NKDLIKENNATRHLCNLLKETCArsaEKTKKYEYEREETRQVYMDLNNNIEKMILAFEELRVQAENARLEMHFKLKE--- 219
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1234 NMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSqrakLQTENGELSRQLDEKEAL----ISQLTRGKLTYT 1309
Cdd:pfam05483  220 DHEKIQHLEEEYKKEINDKEKQVSLLLIQITEKENKMKDLTF----LLEESRDKANQLEEKTKLqdenLKELIEKKDHLT 295
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1310 QQLEDLKRQLEEEVKAKNALAHALQSA-RHDCDLLRE---QYEEETEAKAELQRVLSKANSEVAQWRTKYETDAiQRTEE 1385
Cdd:pfam05483  296 KELEDIKMSLQRSMSTQKALEEDLQIAtKTICQLTEEkeaQMEELNKAKAAHSFVVTEFEATTCSLEELLRTEQ-QRLEK 374
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1386 LEEAKKKLAQRLQ----EAEEAVEAVNAKCSSLEKTKHRLqNEIEDLMVDVERSNAAAAALDKKQRNF-------DKILA 1454
Cdd:pfam05483  375 NEDQLKIITMELQkkssELEEMTKFKNNKEVELEELKKIL-AEDEKLLDEKKQFEKIAEELKGKEQELifllqarEKEIH 453
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1455 EWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTI----HELEKVR 1530
Cdd:pfam05483  454 DLEIQLTAIKTSEEHYLKEVEDLKTELEKEKLKNIELTAHCDKLLLENKELTQEASDMTLELKKHQEDIinckKQEERML 533
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1531 KQ---LEAEKMELQSALEEAEASL--EHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAET 1605
Cdd:pfam05483  534 KQienLEEKEMNLRDELESVREEFiqKGDEVKCKLDKSEENARSIEYEVLKKEKQMKILENKCNNLKKQIENKNKNIEEL 613
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1606 RSRNEALRVKKKMEG-DLNEMEIQLSHANRMAAEAQKQ----VKSLQSLLKDTQIQ----LDDAVRANDDLKENIAIVER 1676
Cdd:pfam05483  614 HQENKALKKKGSAENkQLNAYEIKVNKLELELASAKQKfeeiIDNYQKEIEDKKISeeklLEEVEKAKAIADEAVKLQKE 693
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1677 RNNLLQAELEELRAVVEQTERS-RKLAEQELIE-------TSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQEC 1748
Cdd:pfam05483  694 IDKRCQHKIAEMVALMEKHKHQyDKIIEERDSElglyknkEQEQSSAKAALEIELSNIKAELLSLKKQLEIEKEEKEKLK 773

                   ....*
gi 124302198  1749 RNAEE 1753
Cdd:pfam05483  774 MEAKE 778
PTZ00121 PTZ00121
MAEBL; Provisional
835-1271 1.14e-10

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 67.09  E-value: 1.14e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  835 KIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQ 914
Cdd:PTZ00121 1523 KADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYE 1602
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  915 LEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHatENKVKnlTEEMAGLDEIIAKLTK 994
Cdd:PTZ00121 1603 EEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEE--ENKIK--AAEEAKKAEEDKKKAE 1678
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  995 EKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDlENDKQ 1074
Cdd:PTZ00121 1679 EAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKD-EEEKK 1757
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1075 QLDERlkKKDFELNALNARIEDEQALGSQLQKKlkelqarieeleeeleaERTARAKVEKLRSDLSRELEEISERLEEAG 1154
Cdd:PTZ00121 1758 KIAHL--KKEEEKKAEEIRKEKEAVIEEELDEE-----------------DEKRRMEVDKKIKDIFDNFANIIEGGKEGN 1818
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1155 GATSVQIEM---NKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDV 1231
Cdd:PTZ00121 1819 LVINDSKEMedsAIKEVADSKNMQLEEADAFEKHKFNKNNENGEDGNKEADFNKEKDLKEDDEEEIEEADEIEKIDKDDI 1898
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 124302198 1232 TSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVN 1271
Cdd:PTZ00121 1899 EREIPNNNMAGKNNDIIDDKLDKDEYIKRDAEETREEIIK 1938
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
844-1272 1.69e-10

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 66.20  E-value: 1.69e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   844 EREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMN 923
Cdd:TIGR04523  222 ELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQKELEQNNKKIKELEKQLNQLKSEISDLN 301
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   924 ERLEDE--EEMNAELTAKKRKLE-----------------DECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAG 984
Cdd:TIGR04523  302 NQKEQDwnKELKSELKNQEKKLEeiqnqisqnnkiisqlnEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQS 381
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   985 LDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQ--------------VDDLEGSLEQEKKVRMDLER 1050
Cdd:TIGR04523  382 YKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEierlketiiknnseIKDLTNQDSVKELIIKNLDN 461
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1051 AKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIedeqalgSQLQKKLKELQARIEELEEELEAERTARA 1130
Cdd:TIGR04523  462 TRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEK-------KELEEKVKDLTKKISSLKEKIEKLESEKK 534
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1131 KVEKLRSDLSRELEEISERLEEAGGATSVQ-----IEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKhadsVAELGE 1205
Cdd:TIGR04523  535 EKESKISDLEDELNKDDFELKKENLEKEIDeknkeIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKE----IEEKEK 610
                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 124302198  1206 QIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVND 1272
Cdd:TIGR04523  611 KISSLEKELEKAKKENEKLSSIIKNIKSKKNKLKQEVKQIKETIKEIRNKWPEIIKKIKESKTKIDD 677
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1026-1669 2.30e-10

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 66.09  E-value: 2.30e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1026 KLEQQVDDLEGSLEQEKKVRMDLERAKRKLE--GDLKLTQESIMDLENDKQQLDE-----RLKKKDFELNALNARIEDEQ 1098
Cdd:COG4913   222 DTFEAADALVEHFDDLERAHEALEDAREQIEllEPIRELAERYAAARERLAELEYlraalRLWFAQRRLELLEAELEELR 301
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1099 ALGSQLQKKLKELQARIEELEEELEAERTARAKVE-KLRSDLSRELEEISERLEEAggatsvqiemnKKREAEFQKMRRD 1177
Cdd:COG4913   302 AELARLEAELERLEARLDALREELDELEAQIRGNGgDRLEQLEREIERLERELEER-----------ERRRARLEALLAA 370
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1178 LEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMN 1257
Cdd:COG4913   371 LGLPLPASAEEFAALRAEAAALLEALEEELEALEEALAEAEAALRDLRRELRELEAEIASLERRKSNIPARLLALRDALA 450
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1258 EHRSKAEETQRSVNDLtsqrakLQTENGELS--------------------RQLDEKEALISQL-TRGKLTYtQQLEDLK 1316
Cdd:COG4913   451 EALGLDEAELPFVGEL------IEVRPEEERwrgaiervlggfaltllvppEHYAAALRWVNRLhLRGRLVY-ERVRTGL 523
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1317 RQLEEEVKAKNALAHALQSARHDC-DLLREQYEEET-----EAKAELQRV--------LSKANSEVAQ------WRTKYE 1376
Cdd:COG4913   524 PDPERPRLDPDSLAGKLDFKPHPFrAWLEAELGRRFdyvcvDSPEELRRHpraitragQVKGNGTRHEkddrrrIRSRYV 603
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1377 T--DAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQN--EIEDLMVDVERSNAAAAALDKKQRNFDKI 1452
Cdd:COG4913   604 LgfDNRAKLAALEAELAELEEELAEAEERLEALEAELDALQERREALQRlaEYSWDEIDVASAEREIAELEAELERLDAS 683
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1453 LAEWKQkyeesqselessqkearsLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEqlgssgktihELEKVRKQ 1532
Cdd:COG4913   684 SDDLAA------------------LEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEE----------ELDELQDR 735
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1533 LE-AEKMELQSALEEAEASLEHEEGKILRAQL--EFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRN 1609
Cdd:COG4913   736 LEaAEDLARLELRALLEERFAAALGDAVERELreNLEERIDALRARLNRAEEELERAMRAFNREWPAETADLDADLESLP 815
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1610 EALRVKKKMEGD------------LNEMEIQ-----LSHANRMAAEAQKQVKSLQSLLK------DTQIQLDDAVRANDD 1666
Cdd:COG4913   816 EYLALLDRLEEDglpeyeerfkelLNENSIEfvadlLSKLRRAIREIKERIDPLNDSLKripfgpGRYLRLEARPRPDPE 895

                  ...
gi 124302198 1667 LKE 1669
Cdd:COG4913   896 VRE 898
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1481-1909 3.26e-10

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 65.47  E-value: 3.26e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1481 LFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAE------ASLEHE 1554
Cdd:PRK03918  167 LGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKELEelkeeiEELEKE 246
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1555 EGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNhLRVVDSLQTslDAETRSRNEALRVKKKMEgdLNEMEIQLSHANR 1634
Cdd:PRK03918  247 LESLEGSKRKLEEKIRELEERIEELKKEIEELEEK-VKELKELKE--KAEEYIKLSEFYEEYLDE--LREIEKRLSRLEE 321
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1635 MAAEAQKQVKSLQSLLKDTQiqlddavrandDLKENIAIVERRNNLLQA---ELEELRAVVEQTERSRK-LAEQELIETS 1710
Cdd:PRK03918  322 EINGIEERIKELEEKEERLE-----------ELKKKLKELEKRLEELEErheLYEEAKAKKEELERLKKrLTGLTPEKLE 390
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1711 ERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAvqecRNAEEKAKKAITDAAMMAEELKKEqdtsaHLERMKKNMEQTI 1790
Cdd:PRK03918  391 KELEELEKAKEEIEEEISKITARIGELKKEIKEL----KKAIEELKKAKGKCPVCGRELTEE-----HRKELLEEYTAEL 461
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1791 KDLQHRLDEAEqialkggkKQLQKLEARVRELENELEAEQK--RNAESVKGMRKSERRIKELTYQT-EEDRKNLLRLQDL 1867
Cdd:PRK03918  462 KRIEKELKEIE--------EKERKLRKELRELEKVLKKESEliKLKELAEQLKELEEKLKKYNLEElEKKAEEYEKLKEK 533
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 124302198 1868 VDKLQLKVKAYKRQAEEAEEQANtnlsKFRKVQHELDEAEER 1909
Cdd:PRK03918  534 LIKLKGEIKSLKKELEKLEELKK----KLAELEKKLDELEEE 571
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
914-1343 3.45e-10

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 64.92  E-value: 3.45e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   914 QLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLT 993
Cdd:pfam07888   35 RLEECLQERAELLQAQEAANRQREKEKERYKRDREQWERQRRELESRVAELKEELRQSREKHEELEEKYKELSASSEELS 114
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   994 KEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDK 1073
Cdd:pfam07888  115 EEKDALLAQRAAHEARIRELEEDIKTLTQRVLERETELERMKERAKKAGAQRKEEEAERKQLQAKLQQTEEELRSLSKEF 194
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1074 QQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSreleeiserleEA 1153
Cdd:pfam07888  195 QELRNSLAQRDTQVLQLQDTITTLTQKLTTAHRKEAENEALLEELRSLQERLNASERKVEGLGEELS-----------SM 263
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1154 GGATSvqiemnkKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTS 1233
Cdd:pfam07888  264 AAQRD-------RTQAELHQARLQAAQLTLQLADASLALREGRARWAQERETLQQSAEADKDRIEKLSAELQRLEERLQE 336
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1234 NMEQIIKAKANL--EKMCrtledqmneHRSKAEETQRsvnDLTSQRAKLQTENGELSRQLDEKEALisqltrgkLTYTQQ 1311
Cdd:pfam07888  337 ERMEREKLEVELgrEKDC---------NRVQLSESRR---ELQELKASLRVAQKEKEQLQAEKQEL--------LEYIRQ 396
                          410       420       430
                   ....*....|....*....|....*....|..
gi 124302198  1312 LEdlkRQLEEEVKAKNALAHALQSARHDCDLL 1343
Cdd:pfam07888  397 LE---QRLETVADAKWSEAALTSTERPDSPLS 425
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
839-1293 3.71e-10

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 65.23  E-value: 3.71e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   839 LLKSAEREKEMAS----------MKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQL 908
Cdd:pfam10174  264 LLHTEDREEEIKQmevykshskfMKNKIDQLKQELSKKESELLALQTKLETLTNQNSDCKQHIEVLKESLTAKEQRAAIL 343
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   909 iknkiqlEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEI 988
Cdd:pfam10174  344 -------QTEVDALRLRLEEKESFLNKKTKQLQDLTEEKSTLAGEIRDLKDMLDVKERKINVLQKKIENLQEQLRDKDKQ 416
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   989 IAKLTKEKKALQEAHQQA------LDDLQAEEDKV-NTLTKAKVKLEQQVDDlegSLEQEKKVRMDLERAKRKLEGDLKL 1061
Cdd:pfam10174  417 LAGLKERVKSLQTDSSNTdtalttLEEALSEKERIiERLKEQREREDRERLE---ELESLKKENKDLKEKVSALQPELTE 493
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1062 TQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQarieeleeelEAERTARAKVEklRSDLSR 1141
Cdd:pfam10174  494 KESSLIDLKEHASSLASSGLKKDSKLKSLEIAVEQKKEECSKLENQLKKAH----------NAEEAVRTNPE--INDRIR 561
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1142 ELE-EISERLEEAGGA-TSVQIEMNKKREAEFQKMRRDLEEATLQheataaALRKKHADSVAELGEQIDNLQRVKQKLEK 1219
Cdd:pfam10174  562 LLEqEVARYKEESGKAqAEVERLLGILREVENEKNDKDKKIAELE------SLTLRQMKEQNKKVANIKHGQQEMKKKGA 635
                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 124302198  1220 EKSEFKLELDDVTSNMEQIIKAKANLEKMCRTlEDQMNEHRSKAEETQRSvndLTSQRAKLQTENGELSRQLDE 1293
Cdd:pfam10174  636 QLLEEARRREDNLADNSQQLQLEELMGALEKT-RQELDATKARLSSTQQS---LAEKDGHLTNLRAERRKQLEE 705
PTZ00121 PTZ00121
MAEBL; Provisional
1423-1927 4.10e-10

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 65.55  E-value: 4.10e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1423 NEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSlSTELFKLKNAYE-ESLEHLETFKRE 1501
Cdd:PTZ00121 1082 DAKEDNRADEATEEAFGKAEEAKKTETGKAEEARKAEEAKKKAEDARKAEEARK-AEDARKAEEARKaEDAKRVEIARKA 1160
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1502 NKNLQEEISDLTEQlGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASleHEEGKILRAQLEFNQIKAEIERKLAEKDE 1581
Cdd:PTZ00121 1161 EDARKAEEARKAED-AKKAEAARKAEEVRKAEELRKAEDARKAEAARKA--EEERKAEEARKAEDAKKAEAVKKAEEAKK 1237
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1582 EMEQAKR----NHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDlnemEIQLSHANRMAAEAQK--QVKSLQSLLKDTQi 1655
Cdd:PTZ00121 1238 DAEEAKKaeeeRNNEEIRKFEEARMAHFARRQAAIKAEEARKAD----ELKKAEEKKKADEAKKaeEKKKADEAKKKAE- 1312
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1656 qlddAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSlinQKKKMDadls 1735
Cdd:PTZ00121 1313 ----EAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEE---AKKKAD---- 1381
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1736 qlqtEVEEAVQECRNAEEKAKKAITDAAMmAEELKKEQDTSAHLERMKKNMEQTIKdlqhrLDEAEQialkggkkqlqKL 1815
Cdd:PTZ00121 1382 ----AAKKKAEEKKKADEAKKKAEEDKKK-ADELKKAAAAKKKADEAKKKAEEKKK-----ADEAKK-----------KA 1440
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1816 EARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKnllrlqdlVDKLQLKVKAYKRQAEEAE--EQANTNL 1893
Cdd:PTZ00121 1441 EEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKK--------ADEAKKKAEEAKKKADEAKkaAEAKKKA 1512
                         490       500       510
                  ....*....|....*....|....*....|....*....
gi 124302198 1894 SKFRKVQH-----ELDEAEERADIAESQVNKLRAKSRDI 1927
Cdd:PTZ00121 1513 DEAKKAEEakkadEAKKAEEAKKADEAKKAEEKKKADEL 1551
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
1313-1917 5.69e-10

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 64.74  E-value: 5.69e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1313 EDLKRQLEEEVKAKNALAHALQSARHDCDLLRE--------------QYEEETEAKAELQRVLSKANSEVAQWRTKYETD 1378
Cdd:pfam05483  130 EKVSLKLEEEIQENKDLIKENNATRHLCNLLKEtcarsaektkkyeyEREETRQVYMDLNNNIEKMILAFEELRVQAENA 209
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1379 AIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQ 1458
Cdd:pfam05483  210 RLEMHFKLKEDHEKIQHLEEEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKANQLEEKTKLQDENLKELIE 289
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1459 KyeesqselessqkeARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSgktIHELEKVRKQLEAEKM 1538
Cdd:pfam05483  290 K--------------KDHLTKELEDIKMSLQRSMSTQKALEEDLQIATKTICQLTEEKEAQ---MEELNKAKAAHSFVVT 352
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1539 ELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKdEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKK-- 1616
Cdd:pfam05483  353 EFEATTCSLEELLRTEQQRLEKNEDQLKIITMELQKKSSEL-EEMTKFKNNKEVELEELKKILAEDEKLLDEKKQFEKia 431
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1617 ---------------KMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLK-ENIAIVERRNNL 1680
Cdd:pfam05483  432 eelkgkeqelifllqAREKEIHDLEIQLTAIKTSEEHYLKEVEDLKTELEKEKLKNIELTAHCDKLLlENKELTQEASDM 511
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1681 LQaeleELRAVVEQTERSRKLAEQELietsERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQEcrnAEEKAKKAIT 1760
Cdd:pfam05483  512 TL----ELKKHQEDIINCKKQEERML----KQIENLEEKEMNLRDELESVREEFIQKGDEVKCKLDK---SEENARSIEY 580
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1761 DAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRlDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGM 1840
Cdd:pfam05483  581 EVLKKEKQMKILENKCNNLKKQIENKNKNIEELHQE-NKALKKKGSAENKQLNAYEIKVNKLELELASAKQKFEEIIDNY 659
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1841 RK-------SERRIKELTYQTEEDRKNLLRLQDLVDK-LQLKV-------KAYKRQAEEAEEQANTNLSKFRKVQHELDE 1905
Cdd:pfam05483  660 QKeiedkkiSEEKLLEEVEKAKAIADEAVKLQKEIDKrCQHKIaemvalmEKHKHQYDKIIEERDSELGLYKNKEQEQSS 739
                          650
                   ....*....|..
gi 124302198  1906 AEERADIAESQV 1917
Cdd:pfam05483  740 AKAALEIELSNI 751
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
1477-1923 5.89e-10

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 64.66  E-value: 5.89e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1477 LSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEA---EASLEH 1553
Cdd:TIGR04523  122 LEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLEKEKLNIQKNIDKIknkLLKLEL 201
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1554 ---------EEGKILRAQL-----EFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQ------TSLDAETRSRNEALR 1613
Cdd:TIGR04523  202 llsnlkkkiQKNKSLESQIselkkQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDeqnkikKQLSEKQKELEQNNK 281
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1614 VKKKMEGDLNEMEIQLSHANRMAA-----EAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEEL 1688
Cdd:TIGR04523  282 KIKELEKQLNQLKSEISDLNNQKEqdwnkELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTNSESENSEK 361
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1689 RAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEE 1768
Cdd:TIGR04523  362 QRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSE 441
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1769 LKKEQDTSAHLERMKKNMEQTIKDLQHRLD-------------EAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAE 1835
Cdd:TIGR04523  442 IKDLTNQDSVKELIIKNLDNTRESLETQLKvlsrsinkikqnlEQKQKELKSKEKELKKLNEEKKELEEKVKDLTKKISS 521
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1836 SVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQL-KVKAYKRQAEEAEEQANTNLSKfrkvqhELDEAEERADIAE 1914
Cdd:TIGR04523  522 LKEKIEKLESEKKEKESKISDLEDELNKDDFELKKENLeKEIDEKNKEIEELKQTQKSLKK------KQEEKQELIDQKE 595

                   ....*....
gi 124302198  1915 SQVNKLRAK 1923
Cdd:TIGR04523  596 KEKKDLIKE 604
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1228-1705 9.41e-10

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 63.63  E-value: 9.41e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1228 LDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGK-- 1305
Cdd:COG4717    48 LERLEKEADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLql 127
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1306 LTYTQQLEDLKRQLEEEVKAKNALAHALQSARHdcdlLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEE 1385
Cdd:COG4717   128 LPLYQELEALEAELAELPERLEELEERLEELRE----LEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEE 203
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1386 LEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTK--HRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEES 1463
Cdd:COG4717   204 LQQRLAELEEELEEAQEELEELEEELEQLENELeaAALEERLKEARLLLLIAAALLALLGLGGSLLSLILTIAGVLFLVL 283
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1464 QSELEssqkearsLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSA 1543
Cdd:COG4717   284 GLLAL--------LFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLRE 355
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1544 LEEAEASLEHEEGKILRAQLeFNQIKAEIERKLAEKDEEMEQAkRNHLRVVDSLQTSLDAETRSRNEALRvkkkmEGDLN 1623
Cdd:COG4717   356 AEELEEELQLEELEQEIAAL-LAEAGVEDEEELRAALEQAEEY-QELKEELEELEEQLEELLGELEELLE-----ALDEE 428
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1624 EMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRAN--DDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKL 1701
Cdd:COG4717   429 ELEEELEELEEELEELEEELEELREELAELEAELEQLEEDGelAELLQELEELKAELRELAEEWAALKLALELLEEAREE 508

                  ....
gi 124302198 1702 AEQE 1705
Cdd:COG4717   509 YREE 512
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1615-1836 1.08e-09

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 62.47  E-value: 1.08e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1615 KKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQ 1694
Cdd:COG4942    22 AAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEA 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1695 TER--SRKLAEQELIETSERVQLLHSQNTS--LINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELK 1770
Cdd:COG4942   102 QKEelAELLRALYRLGRQPPLALLLSPEDFldAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALLA 181
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 124302198 1771 KEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQiALKGGKKQLQKLEARVRELENELEAEQKRNAES 1836
Cdd:COG4942   182 ELEEERAALEALKAERQKLLARLEKELAELAA-ELAELQQEAEELEALIARLEAEAAAAAERTPAA 246
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1472-1935 1.40e-09

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 63.54  E-value: 1.40e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1472 KEARSLSTELFKLknayEESLEHLETFKRENKNLQEEISDLTEQLGSsgktiheLEKVRKQLEAEKMELQSALEEAEASL 1551
Cdd:PRK03918  207 REINEISSELPEL----REELEKLEKEVKELEELKEEIEELEKELES-------LEGSKRKLEEKIRELEERIEELKKEI 275
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1552 EHEEGKILRaqLEFNQIKAEIERKLAEKDEEMEQAKRNhlrvVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSH 1631
Cdd:PRK03918  276 EELEEKVKE--LKELKEKAEEYIKLSEFYEEYLDELRE----IEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKE 349
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1632 ANRMAAEAQKQVKSLQSLL-KDTQIQLDDAVRAN---DDLKENIAIVERRNNLLQAELEEL---RAVVEQTERSRKLAEQ 1704
Cdd:PRK03918  350 LEKRLEELEERHELYEEAKaKKEELERLKKRLTGltpEKLEKELEELEKAKEEIEEEISKItarIGELKKEIKELKKAIE 429
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1705 ELIETSERVQLLHSQNTSliNQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAitdaammAEELKKEQDTSAHLERMKK 1784
Cdd:PRK03918  430 ELKKAKGKCPVCGRELTE--EHRKELLEEYTAELKRIEKELKEIEEKERKLRKE-------LRELEKVLKKESELIKLKE 500
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1785 NMEQtIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAeQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLR- 1863
Cdd:PRK03918  501 LAEQ-LKELEEKLKKYNLEELEKKAEEYEKLKEKLIKLKGEIKS-LKKELEKLEELKKKLAELEKKLDELEEELAELLKe 578
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1864 --------LQDLVDKLQLKVKAYKR--QAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGTKGLN 1933
Cdd:PRK03918  579 leelgfesVEELEERLKELEPFYNEylELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKKYSE 658

                  ..
gi 124302198 1934 EE 1935
Cdd:PRK03918  659 EE 660
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1440-1880 1.60e-09

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 62.86  E-value: 1.60e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1440 AALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLtEQLGSS 1519
Cdd:COG4717    49 ERLEKEADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKL-EKLLQL 127
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1520 GKTIHELEKVRKQLEAEKMELQsALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQT 1599
Cdd:COG4717   128 LPLYQELEALEAELAELPERLE-ELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQ 206
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1600 SLDAETRSRNEALRVKKKMEGDLNEMEIQLshanrMAAEAQKQVKSLQSLLK--DTQIQLDDAVRANDDLKENIA----- 1672
Cdd:COG4717   207 RLAELEEELEEAQEELEELEEELEQLENEL-----EAAALEERLKEARLLLLiaAALLALLGLGGSLLSLILTIAgvlfl 281
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1673 ------IVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQ 1746
Cdd:COG4717   282 vlgllaLLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEE 361
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1747 ECRNAEEKAKKA----------ITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALkggKKQLQKLE 1816
Cdd:COG4717   362 ELQLEELEQEIAallaeagvedEEELRAALEQAEEYQELKEELEELEEQLEELLGELEELLEALDEEEL---EEELEELE 438
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 124302198 1817 ARVRELENELEAEQKRnaesvkgMRKSERRIKELTyQTEEDRKNLLRLQDLVDKLQLKVKAYKR 1880
Cdd:COG4717   439 EELEELEEELEELREE-------LAELEAELEQLE-EDGELAELLQELEELKAELRELAEEWAA 494
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
862-1567 2.10e-09

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 62.53  E-value: 2.10e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   862 ALEKSEARRKE-LEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKK 940
Cdd:pfam10174   46 ALRKEEAARISvLKEQYRVTQEENQHLQLTIQALQDELRAQRDLNQLLQQDFTTSPVDGEDKFSTPELTEENFRRLQSEH 125
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   941 RKLEDECSELKRDIDDLELtlaKVEKEKHATENKvknlteemaglDEIIAKLtkekkaLQEAHQQALDDLQAEEDkvNTL 1020
Cdd:pfam10174  126 ERQAKELFLLRKTLEEMEL---RIETQKQTLGAR-----------DESIKKL------LEMLQSKGLPKKSGEED--WER 183
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1021 TKAKVKLEQQVDDLEGSLEQEKKVRMDL-ERAKRKLEGDLKLTQESIMdlendkQQLDERLKKKDFELNALNARIEDE-Q 1098
Cdd:pfam10174  184 TRRIAEAEMQLGHLEVLLDQKEKENIHLrEELHRRNQLQPDPAKTKAL------QTVIEMKDTKISSLERNIRDLEDEvQ 257
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1099 ALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSR---ELEEISERLEEAGGATS---VQIEMNKKREAEfq 1172
Cdd:pfam10174  258 MLKTNGLLHTEDREEEIKQMEVYKSHSKFMKNKIDQLKQELSKkesELLALQTKLETLTNQNSdckQHIEVLKESLTA-- 335
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1173 kmrRDLEEATLQHEATAAALRKKHADSVaeLGEQIDNLQRvkqkLEKEKSEFKLELDDVtSNMEQIIKAKAN-LEKMCRT 1251
Cdd:pfam10174  336 ---KEQRAAILQTEVDALRLRLEEKESF--LNKKTKQLQD----LTEEKSTLAGEIRDL-KDMLDVKERKINvLQKKIEN 405
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1252 LEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLtrgkltyTQQLEDLKRQLEEEVKaknALAH 1331
Cdd:pfam10174  406 LQEQLRDKDKQLAGLKERVKSLQTDSSNTDTALTTLEEALSEKERIIERL-------KEQREREDRERLEELE---SLKK 475
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1332 ALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKK-----KLAQRLQEAEEAVEA 1406
Cdd:pfam10174  476 ENKDLKEKVSALQPELTEKESSLIDLKEHASSLASSGLKKDSKLKSLEIAVEQKKEECSKlenqlKKAHNAEEAVRTNPE 555
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1407 VNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELfKLKN 1486
Cdd:pfam10174  556 INDRIRLLEQEVARYKEESGKAQAEVERLLGILREVENEKNDKDKKIAELESLTLRQMKEQNKKVANIKHGQQEM-KKKG 634
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1487 AYEESLEHLETFKRENKNLQEEISDLTEqlgssgktihELEKVRKQLEAEKMEL---QSALEEAEA---SLEHEEGKILR 1560
Cdd:pfam10174  635 AQLLEEARRREDNLADNSQQLQLEELMG----------ALEKTRQELDATKARLsstQQSLAEKDGhltNLRAERRKQLE 704

                   ....*..
gi 124302198  1561 AQLEFNQ 1567
Cdd:pfam10174  705 EILEMKQ 711
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1063-1283 2.57e-09

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 61.32  E-value: 2.57e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1063 QESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRE 1142
Cdd:COG4942    19 ADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAE 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1143 LEEISERLEE-------AGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRkkhadsvaelgEQIDNLQRVKQ 1215
Cdd:COG4942    99 LEAQKEELAEllralyrLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELR-----------ADLAELAALRA 167
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 124302198 1216 KLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTE 1283
Cdd:COG4942   168 ELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAE 235
PTZ00121 PTZ00121
MAEBL; Provisional
1487-1934 3.51e-09

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 62.47  E-value: 3.51e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1487 AYEESLEHLETFKRENKNLQEEISDLTEQLGSSgktihelEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFN 1566
Cdd:PTZ00121 1092 ATEEAFGKAEEAKKTETGKAEEARKAEEAKKKA-------EDARKAEEARKAEDARKAEEARKAEDAKRVEIARKAEDAR 1164
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1567 qiKAEIERKlAEKDEEMEQAKRnhlrvvdSLQTSLDAETRSRNEAlrvkKKMEGDLNEMEIQLSHANRMAAEAQK--QVK 1644
Cdd:PTZ00121 1165 --KAEEARK-AEDAKKAEAARK-------AEEVRKAEELRKAEDA----RKAEAARKAEEERKAEEARKAEDAKKaeAVK 1230
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1645 SLQSLLKDTQiqldDAVRANddlKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNtsli 1724
Cdd:PTZ00121 1231 KAEEAKKDAE----EAKKAE---EERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAE---- 1299
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1725 nQKKKMDadlsqlqtEVEEAVQECRNAEEKAKKAiTDAAMMAEELKKEQdtsahlERMKKNMEQTIKDLQHRLDEAEQIA 1804
Cdd:PTZ00121 1300 -EKKKAD--------EAKKKAEEAKKADEAKKKA-EEAKKKADAAKKKA------EEAKKAAEAAKAEAEAAADEAEAAE 1363
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1805 LKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQlKVKAYKRQAEE 1884
Cdd:PTZ00121 1364 EKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKK-KADEAKKKAEE 1442
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 124302198 1885 AE--EQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGTKGLNE 1934
Cdd:PTZ00121 1443 AKkaDEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEE 1494
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1038-1447 6.36e-09

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 60.94  E-value: 6.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1038 LEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQalgsqLQKKLKELQARIEE 1117
Cdd:COG4717    76 LEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLLPLYQELEA-----LEAELAELPERLEE 150
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1118 LEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHA 1197
Cdd:COG4717   151 LEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELE 230
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1198 DSVAELgeqidNLQRVKQKLEKEKSEFKLE------LDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVN 1271
Cdd:COG4717   231 QLENEL-----EAAALEERLKEARLLLLIAaallalLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAE 305
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1272 DLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALahALQSARHDCDLLREQY---- 1347
Cdd:COG4717   306 ELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEEL--QLEELEQEIAALLAEAgved 383
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1348 EEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKK-LAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIE 1426
Cdd:COG4717   384 EEELRAALEQAEEYQELKEELEELEEQLEELLGELEELLEALDEEeLEEELEELEEELEELEEELEELREELAELEAELE 463
                         410       420
                  ....*....|....*....|.
gi 124302198 1427 DLMVDVERSNAAAAALDKKQR 1447
Cdd:COG4717   464 QLEEDGELAELLQELEELKAE 484
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
837-1428 8.29e-09

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 61.08  E-value: 8.29e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  837 KPLLKSAEREKEMASMKEEFTRLKEALEKSEARRK--ELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQ 914
Cdd:COG4913   255 EPIRELAERYAAARERLAELEYLRAALRLWFAQRRleLLEAELEELRAELARLEAELERLEARLDALREELDELEAQIRG 334
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  915 LEakvkemNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTK 994
Cdd:COG4913   335 NG------GDRLEQLEREIERLERELEERERRRARLEALLAALGLPLPASAEEFAALRAEAAALLEALEEELEALEEALA 408
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  995 EKKALQEAHQQALDDLQAEedkVNTLTKAKVKLEQQVDDLEGSLEQEKKV---------------------RMDLERA-- 1051
Cdd:COG4913   409 EAEAALRDLRRELRELEAE---IASLERRKSNIPARLLALRDALAEALGLdeaelpfvgelievrpeeerwRGAIERVlg 485
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1052 ---------------------KRKLEGDL-----KLTQESIMDLENDKQQLDERLKKKD--------FELNALNARI--E 1095
Cdd:COG4913   486 gfaltllvppehyaaalrwvnRLHLRGRLvyervRTGLPDPERPRLDPDSLAGKLDFKPhpfrawleAELGRRFDYVcvD 565
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1096 DEQAL-----GSQLQKKLKELQARIEELEEELEAER-----TARAKVEKLRsdlsRELEEISERLEEAggatsvqiemnk 1165
Cdd:COG4913   566 SPEELrrhprAITRAGQVKGNGTRHEKDDRRRIRSRyvlgfDNRAKLAALE----AELAELEEELAEA------------ 629
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1166 krEAEFQKMRRDLEEATLQHEATAAALRKKHAD-SVAELGEQIDNLQRVKQKLEKEKSEFklelddvtsnmeqiikakan 1244
Cdd:COG4913   630 --EERLEALEAELDALQERREALQRLAEYSWDEiDVASAEREIAELEAELERLDASSDDL-------------------- 687
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1245 lekmcRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLT-RGKLTYTQQLEDLKRQLEEEv 1323
Cdd:COG4913   688 -----AALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEdLARLELRALLEERFAAALGD- 761
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1324 KAKNALAHALQSARHDCDLLREQYEEETEAKaeLQRVLSKANSEVAQWRTKYET----DAI---QRTEELEEAKKKLAQR 1396
Cdd:COG4913   762 AVERELRENLEERIDALRARLNRAEEELERA--MRAFNREWPAETADLDADLESlpeyLALldrLEEDGLPEYEERFKEL 839
                         650       660       670
                  ....*....|....*....|....*....|..
gi 124302198 1397 LQEAEEavEAVNAKCSSLEKTKHRLQNEIEDL 1428
Cdd:COG4913   840 LNENSI--EFVADLLSKLRRAIREIKERIDPL 869
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1214-1441 8.90e-09

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 59.78  E-value: 8.90e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1214 KQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDE 1293
Cdd:COG4942    22 AAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEA 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1294 KEALISQLTRgkltyTQQLEDLKRQLEEEVKAKNA--LAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQW 1371
Cdd:COG4942   102 QKEELAELLR-----ALYRLGRQPPLALLLSPEDFldAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAEL 176
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1372 RTKYETDAIQRtEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAA 1441
Cdd:COG4942   177 EALLAELEEER-AALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPA 245
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
1668-1925 9.85e-09

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 60.72  E-value: 9.85e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1668 KENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQ-----------ELIETSERVQLLHSQNTSLINQKKKMDADLSQ 1736
Cdd:COG1196   185 EENLERLEDILGELERQLEPLERQAEKAERYRELKEElkeleaellllKLRELEAELEELEAELEELEAELEELEAELAE 264
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1737 LQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQiALKGGKKQLQKLE 1816
Cdd:COG1196   265 LEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEE-ELEELEEELEELE 343
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1817 ARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDlvdklQLKVKAYKRQAEEAEEQANTN-LSK 1895
Cdd:COG1196   344 EELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALR-----AAAELAAQLEELEEAEEALLErLER 418
                         250       260       270
                  ....*....|....*....|....*....|
gi 124302198 1896 FRKVQHELDEAEERADIAESQVNKLRAKSR 1925
Cdd:COG1196   419 LEEELEELEEALAELEEEEEEEEEALEEAA 448
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
945-1152 1.06e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 59.39  E-value: 1.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  945 DECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQeahqqalDDLQAEEDKVNTLTKAK 1024
Cdd:COG4942    20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALE-------QELAALEAELAELEKEI 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1025 VKLEQQVDDLEGSLEQEKKVrmdLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQL 1104
Cdd:COG4942    93 AELRAELEAQKEELAELLRA---LYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAEL 169
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 124302198 1105 QKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEE 1152
Cdd:COG4942   170 EAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAE 217
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
831-1145 1.17e-08

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 60.46  E-value: 1.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  831 KLYFKIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIK 910
Cdd:PRK03918  477 KLRKELRELEKVLKKESELIKLKELAEQLKELEEKLKKYNLEELEKKAEEYEKLKEKLIKLKGEIKSLKKELEKLEELKK 556
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  911 NKIQLEAKVKEMNERLedeeemnAELTAKKRKLEDEC-SELKRDIDDLE------LTLAKVEKEKHATENKVKNLTEEma 983
Cdd:PRK03918  557 KLAELEKKLDELEEEL-------AELLKELEELGFESvEELEERLKELEpfyneyLELKDAEKELEREEKELKKLEEE-- 627
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  984 gLDEIIAKLTKEKKALQEAHQQaLDDLQAEEDKvntltkakvkleqqvDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQ 1063
Cdd:PRK03918  628 -LDKAFEELAETEKRLEELRKE-LEELEKKYSE---------------EEYEELREEYLELSRELAGLRAELEELEKRRE 690
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1064 ESIMDLENDKQQLDERLKKKDfELNALNARIEDEQAlgsqLQKKLKELQARIeeleeeleaERTARAKVEKLRSDLSREL 1143
Cdd:PRK03918  691 EIKKTLEKLKEELEEREKAKK-ELEKLEKALERVEE----LREKVKKYKALL---------KERALSKVGEIASEIFEEL 756

                  ..
gi 124302198 1144 EE 1145
Cdd:PRK03918  757 TE 758
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1592-1894 1.58e-08

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 59.65  E-value: 1.58e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1592 RVVDSLQ--TSLDAETRSRNEAL-----RVKKKMEGDLNEMEIQLSHANrmAAEAQKQVKSLQSLLKDTQIQLddavran 1664
Cdd:COG3206    98 RVVDKLNldEDPLGEEASREAAIerlrkNLTVEPVKGSNVIEISYTSPD--PELAAAVANALAEAYLEQNLEL------- 168
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1665 ddlkeNIAIVERRNNLLQAELEELRAVVEQTERSRK--LAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVE 1742
Cdd:COG3206   169 -----RREEARKALEFLEEQLPELRKELEEAEAALEefRQKNGLVDLSEEAKLLLQQLSELESQLAEARAELAEAEARLA 243
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1743 eAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMK----------KNMEQTIKDLQHRLDEAEQIALKGGKKQL 1812
Cdd:COG3206   244 -ALRAQLGSGPDALPELLQSPVIQQLRAQLAELEAELAELSarytpnhpdvIALRAQIAALRAQLQQEAQRILASLEAEL 322
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1813 QKLEARVRELENELEAEQKRnaesVKGMRKSERRIKELTYQTEEDRKNllrLQDLVDKLQlkvkaykrQAEEAEEQANTN 1892
Cdd:COG3206   323 EALQAREASLQAQLAQLEAR----LAELPELEAELRRLEREVEVAREL---YESLLQRLE--------EARLAEALTVGN 387

                  ..
gi 124302198 1893 LS 1894
Cdd:COG3206   388 VR 389
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
853-1428 3.53e-08

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 58.81  E-value: 3.53e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  853 KEEFTRLKEALEK--SEARRKELEEKMVSLLQEKNDLQLQVQAEQD---NLADAEERCDQLIKNKIQLEAKVKEMNERLE 927
Cdd:COG3096   471 RRQFEKAYELVCKiaGEVERSQAWQTARELLRRYRSQQALAQRLQQlraQLAELEQRLRQQQNAERLLEEFCQRIGQQLD 550
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  928 DEEEmnaeltakkrkLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGL----------DEIIAKLTKE-- 995
Cdd:COG3096   551 AAEE-----------LEELLAELEAQLEELEEQAAEAVEQRSELRQQLEQLRARIKELaarapawlaaQDALERLREQsg 619
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  996 -----KKALQEAHQQALDD---LQAEEDKvntLTKAKVKLEQQV------------------------------DD---- 1033
Cdd:COG3096   620 ealadSQEVTAAMQQLLERereATVERDE---LAARKQALESQIerlsqpggaedprllalaerlggvllseiyDDvtle 696
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1034 -------LEGSLEQEKKVRmDLERAKRKLEGdLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQK 1106
Cdd:COG3096   697 dapyfsaLYGPARHAIVVP-DLSAVKEQLAG-LEDCPEDLYLIEGDPDSFDDSVFDAEELEDAVVVKLSDRQWRYSRFPE 774
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1107 klkelqarieeleeeleAERTARAKVEKLRSDLSRELEEISERLEEAggATSVQiemnkkreaEFQKMRRDLEEATLQH- 1185
Cdd:COG3096   775 -----------------VPLFGRAAREKRLEELRAERDELAEQYAKA--SFDVQ---------KLQRLHQAFSQFVGGHl 826
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1186 --------EATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKL--------ELDDVTSNMEQIIKAKANLEKmC 1249
Cdd:COG3096   827 avafapdpEAELAALRQRRSELERELAQHRAQEQQLRQQLDQLKEQLQLlnkllpqaNLLADETLADRLEELREELDA-A 905
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1250 RTLEDQMNEHRSKAEETQRSVNDLTS---QRAKLQTENGELSRQLDEKEALISQLT-----RGKLTYtqqlEDLKRQLEE 1321
Cdd:COG3096   906 QEAQAFIQQHGKALAQLEPLVAVLQSdpeQFEQLQADYLQAKEQQRRLKQQIFALSevvqrRPHFSY----EDAVGLLGE 981
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1322 EVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSevaQWRTKYET--DAIQRTEELE-----EAKKKLA 1394
Cdd:COG3096   982 NSDLNEKLRARLEQAEEARREAREQLRQAQAQYSQYNQVLASLKS---SRDAKQQTlqELEQELEELGvqadaEAEERAR 1058
                         650       660       670
                  ....*....|....*....|....*....|....
gi 124302198 1395 QRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDL 1428
Cdd:COG3096  1059 IRRDELHEELSQNRSRRSQLEKQLTRCEAEMDSL 1092
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1647-1897 3.54e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 57.85  E-value: 3.54e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1647 QSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQllhsqntSLINQ 1726
Cdd:COG4942    19 ADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELA-------ELEKE 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1727 KKKMDADLSQLQTEVEEAVqecRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQI--A 1804
Cdd:COG4942    92 IAELRAELEAQKEELAELL---RALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALraE 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1805 LKGGKKQLQKLEARVRELENELEAEQKRNAESVKgmrKSERRIKELTYQTEEDRKNLLRLQDLVDKLQlkvkayKRQAEE 1884
Cdd:COG4942   169 LEAERAELEALLAELEEERAALEALKAERQKLLA---RLEKELAELAAELAELQQEAEELEALIARLE------AEAAAA 239
                         250
                  ....*....|...
gi 124302198 1885 AEEQANTNLSKFR 1897
Cdd:COG4942   240 AERTPAAGFAALK 252
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
861-1082 3.76e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 57.85  E-value: 3.76e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  861 EALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKK 940
Cdd:COG4942    20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAEL 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  941 RKLEDECSELKRDIddleltlakvekEKHATENKVKNLT-----EEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEED 1015
Cdd:COG4942   100 EAQKEELAELLRAL------------YRLGRQPPLALLLspedfLDAVRRLQYLKYLAPARREQAEELRADLAELAALRA 167
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 124302198 1016 KVNTLTKAKVKLEQQVDDLEGSLEQEKKVRmdlERAKRKLEGDLKLTQESIMDLENDKQQLDERLKK 1082
Cdd:COG4942   168 ELEAERAELEALLAELEEERAALEALKAER---QKLLARLEKELAELAAELAELQQEAEELEALIAR 231
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
1681-1928 4.66e-08

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 58.65  E-value: 4.66e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1681 LQAELEELRAVVEQteRSRKLaEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEavQECRNAEEKAKKAIT 1760
Cdd:pfam01576   55 LCAEAEEMRARLAA--RKQEL-EEILHELESRLEEEEERSQQLQNEKKKMQQHIQDLEEQLDE--EEAARQKLQLEKVTT 129
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1761 DAAM--MAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIAlKGGKKQLQKLEARVRELENELEAEQKRNAESVK 1838
Cdd:pfam01576  130 EAKIkkLEEDILLLEDQNSKLSKERKLLEERISEFTSNLAEEEEKA-KSLSKLKNKHEAMISDLEERLKKEEKGRQELEK 208
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1839 GMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVN 1918
Cdd:pfam01576  209 AKRKLEGESTDLQEQIAELQAQIAELRAQLAKKEEELQAALARLEEETAQKNNALKKIRELEAQISELQEDLESERAARN 288
                          250
                   ....*....|
gi 124302198  1919 KLRAKSRDIG 1928
Cdd:pfam01576  289 KAEKQRRDLG 298
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1010-1223 6.26e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 57.08  E-value: 6.26e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1010 LQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNA 1089
Cdd:COG4942    15 AAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAE 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1090 LNARIEDEQALGSQLQKKL--KELQARIEELEEELEAERTARA-----KVEKLRSDLSRELEEISERLEEAGGATSVQIE 1162
Cdd:COG4942    95 LRAELEAQKEELAELLRALyrLGRQPPLALLLSPEDFLDAVRRlqylkYLAPARREQAEELRADLAELAALRAELEAERA 174
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 124302198 1163 MNKKREAEFQKMRRDLEEATLQHEATAAALRKK---HADSVAELGEQIDNLQRVKQKLEKEKSE 1223
Cdd:COG4942   175 ELEALLAELEEERAALEALKAERQKLLARLEKElaeLAAELAELQQEAEELEALIARLEAEAAA 238
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
1240-1921 6.49e-08

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 57.93  E-value: 6.49e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1240 KAKANLEKMCRTLEDQ-----MNEHRSKAEETQRSVNDLTSQRAKLQTengeLSRQLDEKEALISQLTRGKLTYTQQLED 1314
Cdd:pfam12128  215 KSRLNRQQVEHWIRDIqaiagIMKIRPEFTKLQQEFNTLESAELRLSH----LHFGYKSDETLIASRQEERQETSAELNQ 290
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1315 LKRQLEEEVKAK--------NALAHALQSARHDCDLLREQYEEETEAKAElqrVLSKANSEVAQWRTKyetdaiqrTEEL 1386
Cdd:pfam12128  291 LLRTLDDQWKEKrdelngelSAADAAVAKDRSELEALEDQHGAFLDADIE---TAAADQEQLPSWQSE--------LENL 359
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1387 EEAKKKLAQRLQEAEEAVEAVNAKCSSlektkhRLQNEIEDLMVDVERSNAAAAALDKKQRN-FDKILAEWKQKYEESQS 1465
Cdd:pfam12128  360 EERLKALTGKHQDVTAKYNRRRSKIKE------QNNRDIAGIKDKLAKIREARDRQLAVAEDdLQALESELREQLEAGKL 433
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1466 ELESSQKEARSLSTELFKLKN---AYEESLEHLETFkrenknlQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQS 1542
Cdd:pfam12128  434 EFNEEEYRLKSRLGELKLRLNqatATPELLLQLENF-------DERIERAREEQEAANAEVERLQSELRQARKRRDQASE 506
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1543 ALEEAEASLEHEEGKILRAQ----------LEFNQIKAEIERKLAEKDEEMEQAKRNHLR-VVDSLQTS---------LD 1602
Cdd:pfam12128  507 ALRQASRRLEERQSALDELElqlfpqagtlLHFLRKEAPDWEQSIGKVISPELLHRTDLDpEVWDGSVGgelnlygvkLD 586
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1603 AETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRAnddLKENIAIVERRNNLLQ 1682
Cdd:pfam12128  587 LKRIDVPEWAASEEELRERLDKAEEALQSAREKQAAAEEQLVQANGELEKASREETFARTA---LKNARLDLRRLFDEKQ 663
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1683 AELeelRAVVEQTERSRKLAEqelietsERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAiTDA 1762
Cdd:pfam12128  664 SEK---DKKNKALAERKDSAN-------ERLNSLEAQLKQLDKKHQAWLEEQKEQKREARTEKQAYWQVVEGALDA-QLA 732
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1763 AMMAEELKKEQDTSAHLERMKKNMEqtiKDLQHRLDEAEQIAlkggkkqlqKLEARVRELENELEAEQKRNAESVKGMRK 1842
Cdd:pfam12128  733 LLKAAIAARRSGAKAELKALETWYK---RDLASLGVDPDVIA---------KLKREIRTLERKIERIAVRRQEVLRYFDW 800
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1843 SERRI----KELTYQTEEDRKNLLRLQDLVDKLQLKVKAyKRQAEEAEEQANtnlskfRKVQHELDEAEERADIAESQVN 1918
Cdd:pfam12128  801 YQETWlqrrPRLATQLSNIERAISELQQQLARLIADTKL-RRAKLEMERKAS------EKQQVRLSENLRGLRCEMSKLA 873

                   ...
gi 124302198  1919 KLR 1921
Cdd:pfam12128  874 TLK 876
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
1356-1930 8.63e-08

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 57.34  E-value: 8.63e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1356 ELQRVLSKANSEVA---QWRTKYETDAIQRTEELEEAKKKLAQRLQE---AEEAVEAVNAKCSSLEKTKHRLQNEIEDLM 1429
Cdd:TIGR04523  100 KLNSDLSKINSEIKndkEQKNKLEVELNKLEKQKKENKKNIDKFLTEikkKEKELEKLNNKYNDLKKQKEELENELNLLE 179
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1430 VDversnaaaaaLDKKQRNFDKILAEWKQKYEESQSELESSQKEaRSLSTELFKLKNAYEESLEHLETFKRENKNLQEEI 1509
Cdd:TIGR04523  180 KE----------KLNIQKNIDKIKNKLLKLELLLSNLKKKIQKN-KSLESQISELKKQNNQLKDNIEKKQQEINEKTTEI 248
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1510 SDLTEQLGSsgkTIHELEKVRKQLEAEKMELQSAleeaeasleheEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRN 1589
Cdd:TIGR04523  249 SNTQTQLNQ---LKDEQNKIKKQLSEKQKELEQN-----------NKKIKELEKQLNQLKSEISDLNNQKEQDWNKELKS 314
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1590 HLRVVDS----LQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRAND 1665
Cdd:TIGR04523  315 ELKNQEKkleeIQNQISQNNKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQIN 394
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1666 DLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAV 1745
Cdd:TIGR04523  395 DLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLS 474
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1746 QECRNAEEKAKKaitdaamMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDE--AEQIALKGGKKQLQK--------- 1814
Cdd:TIGR04523  475 RSINKIKQNLEQ-------KQKELKSKEKELKKLNEEKKELEEKVKDLTKKISSlkEKIEKLESEKKEKESkisdledel 547
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1815 -----------LEARVRELENELEaEQKRNAESVKgmrKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVkayKRQAE 1883
Cdd:TIGR04523  548 nkddfelkkenLEKEIDEKNKEIE-ELKQTQKSLK---KKQEEKQELIDQKEKEKKDLIKEIEEKEKKISSL---EKELE 620
                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....*..
gi 124302198  1884 EAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGTK 1930
Cdd:TIGR04523  621 KAKKENEKLSSIIKNIKSKKNKLKQEVKQIKETIKEIRNKWPEIIKK 667
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
851-1033 9.40e-08

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 54.93  E-value: 9.40e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  851 SMKEEFTRLKEaLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLE-DE 929
Cdd:COG1579     1 AMPEDLRALLD-LQELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKkYE 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  930 EEMNAELTAKKRK-LEDECSELKRDIDDLEltlakvEKEKHATEnKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALD 1008
Cdd:COG1579    80 EQLGNVRNNKEYEaLQKEIESLKRRISDLE------DEILELME-RIEELEEELAELEAELAELEAELEEKKAELDEELA 152
                         170       180
                  ....*....|....*....|....*
gi 124302198 1009 DLQAEEDKvntLTKAKVKLEQQVDD 1033
Cdd:COG1579   153 ELEAELEE---LEAEREELAAKIPP 174
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1240-1455 9.96e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 56.31  E-value: 9.96e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1240 KAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQL 1319
Cdd:COG4942    20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAEL 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1320 EEEVKA-KNALAHALQSARHDCDLLREQYEEETEAKAELQRVlskanSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ 1398
Cdd:COG4942   100 EAQKEElAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYL-----KYLAPARREQAEELRADLAELAALRAELEAERA 174
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 124302198 1399 EAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAE 1455
Cdd:COG4942   175 ELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIAR 231
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
1185-1926 1.05e-07

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 57.54  E-value: 1.05e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1185 HEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAE 1264
Cdd:pfam12128  228 RDIQAIAGIMKIRPEFTKLQQEFNTLESAELRLSHLHFGYKSDETLIASRQEERQETSAELNQLLRTLDDQWKEKRDELN 307
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1265 etqrsvNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQsarhdcDLLR 1344
Cdd:pfam12128  308 ------GELSAADAAVAKDRSELEALEDQHGAFLDADIETAAADQEQLPSWQSELENLEERLKALTGKHQ------DVTA 375
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1345 EQYEEETEAKAELQRVLSKANSEVAQwrtKYETDAIQRTEElEEAKKKLAQRLQEAEEAVEAvnakcsSLEKTKHRLQNE 1424
Cdd:pfam12128  376 KYNRRRSKIKEQNNRDIAGIKDKLAK---IREARDRQLAVA-EDDLQALESELREQLEAGKL------EFNEEEYRLKSR 445
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1425 IEDLMVdveRSNAAAAALDKK--QRNFDKILAEWKQKyeesqseLESSQKEARSLSTELFKLKNAYEESLEHLETFKREN 1502
Cdd:pfam12128  446 LGELKL---RLNQATATPELLlqLENFDERIERAREE-------QEAANAEVERLQSELRQARKRRDQASEALRQASRRL 515
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1503 KNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAE---KMELQSALEEAEASLEHEEGKIlRAQLEFNQIKAEIERKLAEK 1579
Cdd:pfam12128  516 EERQSALDELELQLFPQAGTLLHFLRKEAPDWEQsigKVISPELLHRTDLDPEVWDGSV-GGELNLYGVKLDLKRIDVPE 594
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1580 DEEMEQAKRNHLrvvDSLQTSLDAEtRSRNEALrvkkkmegdlnemEIQLSHANRMAAEAQKQVKSLQSLLK---DTQIQ 1656
Cdd:pfam12128  595 WAASEEELRERL---DKAEEALQSA-REKQAAA-------------EEQLVQANGELEKASREETFARTALKnarLDLRR 657
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1657 LDDAVRANDDLKENiaIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETServqllhSQNTSLINQKKK-----MD 1731
Cdd:pfam12128  658 LFDEKQSEKDKKNK--ALAERKDSANERLNSLEAQLKQLDKKHQAWLEEQKEQK-------REARTEKQAYWQvvegaLD 728
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1732 ADLSQLQTEVeEAVQECRNAEEKAKKaitdaAMMAEELKK---EQDTSAHLERMKKNMEQTIKDLQHRLDEA---EQIAL 1805
Cdd:pfam12128  729 AQLALLKAAI-AARRSGAKAELKALE-----TWYKRDLASlgvDPDVIAKLKREIRTLERKIERIAVRRQEVlryFDWYQ 802
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1806 KGGKKQLQKLEARVRELEN---ELEAEQKRNAESVKgmrkseRRIKELtyqtEEDRKNLLRLQDLVDKLQLKVKAYKRQA 1882
Cdd:pfam12128  803 ETWLQRRPRLATQLSNIERaisELQQQLARLIADTK------LRRAKL----EMERKASEKQQVRLSENLRGLRCEMSKL 872
                          730       740       750       760
                   ....*....|....*....|....*....|....*....|....
gi 124302198  1883 EEAEEQANTNlSKFRKVQHELDEAEERADIAESQVNKLRAKSRD 1926
Cdd:pfam12128  873 ATLKEDANSE-QAQGSIGERLAQLEDLKLKRDYLSESVKKYVEH 915
PRK04778 PRK04778
septation ring formation regulator EzrA; Provisional
833-1283 1.23e-07

septation ring formation regulator EzrA; Provisional


Pssm-ID: 179877 [Multi-domain]  Cd Length: 569  Bit Score: 56.77  E-value: 1.23e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  833 YFKIKPLLKSAER-----EKEMASMKEEFTRLKEALEKSEARRKELEEKMvsllqekNDLQLQVQAEQDNLADAEErcdq 907
Cdd:PRK04778  100 FRKAKHEINEIESlldliEEDIEQILEELQELLESEEKNREEVEQLKDLY-------RELRKSLLANRFSFGPALD---- 168
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  908 liknkiQLEAKVKEMNERLEDEEEMNAE---LTAKK--RKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKN----L 978
Cdd:PRK04778  169 ------ELEKQLENLEEEFSQFVELTESgdyVEAREilDQLEEELAALEQIMEEIPELLKELQTELPDQLQELKAgyreL 242
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  979 TEEMAGLDEIiaKLTKEKKALQEAHQQALDDLQAEEdkvntLTKAKVKLEQ---QVDDLEGSLEQEKKVRMDLERAKRKL 1055
Cdd:PRK04778  243 VEEGYHLDHL--DIEKEIQDLKEQIDENLALLEELD-----LDEAEEKNEEiqeRIDQLYDILEREVKARKYVEKNSDTL 315
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1056 EGDLKLTQESIMDLENDKQQLDERlkkkdFELNalnariEDEQALGSQLQKKLKELQARIEELEEELeaertarAKVEKL 1135
Cdd:PRK04778  316 PDFLEHAKEQNKELKEEIDRVKQS-----YTLN------ESELESVRQLEKQLESLEKQYDEITERI-------AEQEIA 377
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1136 RSDLSRELEEISERLEEAggatsvqiemnKKREAEFQKMRRDLEEATLQHEATAAALRKKhadsvaelgeqidnLQRVKQ 1215
Cdd:PRK04778  378 YSELQEELEEILKQLEEI-----------EKEQEKLSEMLQGLRKDELEAREKLERYRNK--------------LHEIKR 432
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 124302198 1216 KLEKEK-----SEFKLELDDVTSNMEQiikakanlekmcrtLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTE 1283
Cdd:PRK04778  433 YLEKSNlpglpEDYLEMFFEVSDEIEA--------------LAEELEEKPINMEAVNRLLEEATEDVETLEEE 491
PRK01156 PRK01156
chromosome segregation protein; Provisional
833-1408 1.26e-07

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 56.83  E-value: 1.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  833 YFKIKPLLKSAERE-KEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQA---EQDNLADAEERCDQL 908
Cdd:PRK01156  168 YDKLKDVIDMLRAEiSNIDYLEEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNamdDYNNLKSALNELSSL 247
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  909 IKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLedecselkrdiddLELTLAKVEKEKHATeNKVKNLTEEMAGLDEI 988
Cdd:PRK01156  248 EDMKNRYESEIKTAESDLSMELEKNNYYKELEERH-------------MKIINDPVYKNRNYI-NDYFKYKNDIENKKQI 313
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  989 IAKLTKEKKALQEAHQQaLDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSleqekkvRMDLERAKRKLEGDLKLTQESIMD 1068
Cdd:PRK01156  314 LSNIDAEINKYHAIIKK-LSVLQKDYNDYIKKKSRYDDLNNQILELEGY-------EMDYNSYLKSIESLKKKIEEYSKN 385
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1069 LENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARA------------------ 1130
Cdd:PRK01156  386 IERMSAFISEILKIQEIDPDAIKKELNEINVKLQDISSKVSSLNQRIRALRENLDELSRNMEmlngqsvcpvcgttlgee 465
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1131 KVEKLRSDLSRELEEISE---RLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQI 1207
Cdd:PRK01156  466 KSNHIINHYNEKKSRLEEkirEIEIEVKDIDEKIVDLKKRKEYLESEEINKSINEYNKIESARADLEDIKIKINELKDKH 545
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1208 DnlqrvkqKLEKEKSEFK-LELDDVTSNMEQIIKAKANLEKM-CRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENG 1285
Cdd:PRK01156  546 D-------KYEEIKNRYKsLKLEDLDSKRTSWLNALAVISLIdIETNRSRSNEIKKQLNDLESRLQEIEIGFPDDKSYID 618
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1286 ELSRQLDEKealiSQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKAN 1365
Cdd:PRK01156  619 KSIREIENE----ANNLNNKYNEIQENKILIEKLRGKIDNYKKQIAEIDSIIPDLKEITSRINDIEDNLKKSRKALDDAK 694
                         570       580       590       600
                  ....*....|....*....|....*....|....*....|...
gi 124302198 1366 SEVAQWRTKYETDaIQRTEELEEAKKKLAQRLQEAEEAVEAVN 1408
Cdd:PRK01156  695 ANRARLESTIEIL-RTRINELSDRINDINETLESMKKIKKAIG 736
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
839-1056 1.37e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 55.93  E-value: 1.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  839 LLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAK 918
Cdd:COG4942    12 ALAAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKE 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  919 VKEMNERLEDEEEMNAELTAKKRKLEDEcSELK-----RDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLT 993
Cdd:COG4942    92 IAELRAELEAQKEELAELLRALYRLGRQ-PPLAlllspEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELE 170
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 124302198  994 KEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLE 1056
Cdd:COG4942   171 AERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLE 233
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
929-1424 1.52e-07

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 56.31  E-value: 1.52e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  929 EEEMNAELTAKKRKLEDECSELKRDIDDLElTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALqEAHQQALD 1008
Cdd:COG4717    52 EKEADELFKPQGRKPELNLKELKELEEELK-EAEEKEEEYAELQEELEELEEELEELEAELEELREELEKL-EKLLQLLP 129
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1009 DLQAEEDKVNTLTKAKVKLEQqvddlegsLEQEKKVRMDLERAKRKLEGDLKLTQESI-MDLENDKQQLDERLKKKDFEL 1087
Cdd:COG4717   130 LYQELEALEAELAELPERLEE--------LEERLEELRELEEELEELEAELAELQEELeELLEQLSLATEEELQDLAEEL 201
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1088 NALNARIEDEQALGSQLQKKLKELQARIEeleeeleaertaRAKVEKLRSDLSRELEEISERLEEAGG-----ATSVQIE 1162
Cdd:COG4717   202 EELQQRLAELEEELEEAQEELEELEEELE------------QLENELEAAALEERLKEARLLLLIAAAllallGLGGSLL 269
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1163 MNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQID----NLQRVKQKLEKEKSEFKLELDDVTSNMEQI 1238
Cdd:COG4717   270 SLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALEEleeeELEELLAALGLPPDLSPEELLELLDRIEEL 349
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1239 IKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQtengelsrQLDEKEALisqltrgkltyTQQLEDLKRQ 1318
Cdd:COG4717   350 QELLREAEELEEELQLEELEQEIAALLAEAGVEDEEELRAALE--------QAEEYQEL-----------KEELEELEEQ 410
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1319 LEEEVKAKNALAhalqsARHDCDLLREQYEEETEAKAELQRVLSKANSEVAqwRTKYETDAIQRTEELEEAKKKLAQRLQ 1398
Cdd:COG4717   411 LEELLGELEELL-----EALDEEELEEELEELEEELEELEEELEELREELA--ELEAELEQLEEDGELAELLQELEELKA 483
                         490       500
                  ....*....|....*....|....*....
gi 124302198 1399 EAEEAVEAVNAKC---SSLEKTKHRLQNE 1424
Cdd:COG4717   484 ELRELAEEWAALKlalELLEEAREEYREE 512
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1317-1775 1.53e-07

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 56.31  E-value: 1.53e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1317 RQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWrtkyetDAIQRTEELEEAKKKLAQR 1396
Cdd:COG4717    74 KELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLL------PLYQELEALEAELAELPER 147
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1397 LQEAEEAVEAVN---AKCSSLEKTKHRLQNEIEDLMVDVerSNAAAAALDKKQRNFDKILAEWKQkyeesqselesSQKE 1473
Cdd:COG4717   148 LEELEERLEELReleEELEELEAELAELQEELEELLEQL--SLATEEELQDLAEELEELQQRLAE-----------LEEE 214
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1474 ARSLSTELfklkNAYEESLEHLETfKRENKNLQEEISDLTEQLGSSGkTIHELEKVRKQLEAEKMELQSALEEAEASLEH 1553
Cdd:COG4717   215 LEEAQEEL----EELEEELEQLEN-ELEAAALEERLKEARLLLLIAA-ALLALLGLGGSLLSLILTIAGVLFLVLGLLAL 288
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1554 EEGKILRAQLEFNQIKAEIERKLAEKDEEMEQakrnhlrvVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHAN 1633
Cdd:COG4717   289 LFLLLAREKASLGKEAEELQALPALEELEEEE--------LEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELE 360
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1634 RmAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLA---------EQ 1704
Cdd:COG4717   361 E-ELQLEELEQEIAALLAEAGVEDEEELRAALEQAEEYQELKEELEELEEQLEELLGELEELLEALDEEeleeeleelEE 439
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 124302198 1705 ELIETSERVQLLHSQNTSLINQKKKM--DADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDT 1775
Cdd:COG4717   440 ELEELEEELEELREELAELEAELEQLeeDGELAELLQELEELKAELRELAEEWAALKLALELLEEAREEYREE 512
Motor_domain cd01363
Myosin and Kinesin motor domain; Myosin and Kinesin motor domain. These ATPases belong to the ...
651-675 2.03e-07

Myosin and Kinesin motor domain; Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes. Some of the names do not match with what is given in the sequence list. This is because they are based on the current nomenclature by Kollmar/Sebe-Pedros.


Pssm-ID: 276814 [Multi-domain]  Cd Length: 170  Bit Score: 52.73  E-value: 2.03e-07
                          10        20
                  ....*....|....*....|....*
gi 124302198  651 HRENLNKLMTNLRSTHPHFVRCIIP 675
Cdd:cd01363   146 INESLNTLMNVLRATRPHFVRCISP 170
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
859-1874 2.20e-07

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 56.60  E-value: 2.20e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   859 LKEALEKSEARRKeLEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIK--NKIQLEAKVKEMNerLEDEEEMNAEL 936
Cdd:TIGR01612  546 LKESYELAKNWKK-LIHEIKKELEEENEDSIHLEKEIKDLFDKYLEIDDEIIyiNKLKLELKEKIKN--ISDKNEYIKKA 622
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   937 TAKKRKLEDECSElkrdIDDleltLAKVEKEKhatenkvknLTEEMAGLDEIIAKLTKEkkaLQEAHQQALDDLQ----- 1011
Cdd:TIGR01612  623 IDLKKIIENNNAY----IDE----LAKISPYQ---------VPEHLKNKDKIYSTIKSE---LSKIYEDDIDALYnelss 682
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1012 --AEEDKVNTLTKAKvkleqqVDDLEGSLEQEKKVRMDLERAKRKLegdlkltqeSIMDLENDKQQLDE---RLKKKDF- 1085
Cdd:TIGR01612  683 ivKENAIDNTEDKAK------LDDLKSKIDKEYDKIQNMETATVEL---------HLSNIENKKNELLDiivEIKKHIHg 747
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1086 ELNA-LNARIEDeqalgsqLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMN 1164
Cdd:TIGR01612  748 EINKdLNKILED-------FKNKEKELSNKINDYAKEKDELNKYKSKISEIKNHYNDQINIDNIKDEDAKQNYDKSKEYI 820
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1165 KK---REAEFQKM---RRDLEEATLQHEATAAALRKKHADSVAELGEQIDNL-QRVKQKLEKEK-SEFKLELDDVTSNME 1236
Cdd:TIGR01612  821 KTisiKEDEIFKIineMKFMKDDFLNKVDKFINFENNCKEKIDSEHEQFAELtNKIKAEISDDKlNDYEKKFNDSKSLIN 900
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1237 QIIKAKANLEKMCRTLEdQMNEHRSKAEETQRSVNDLTSQRAKL------------QTENGELSRQLDEKEALISQLTRG 1304
Cdd:TIGR01612  901 EINKSIEEEYQNINTLK-KVDEYIKICENTKESIEKFHNKQNILkeilnknidtikESNLIEKSYKDKFDNTLIDKINEL 979
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1305 KLTYTQ-QLEDLKRQLEEEVKAKNALAHALQSARHdcDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRT 1383
Cdd:TIGR01612  980 DKAFKDaSLNDYEAKNNELIKYFNDLKANLGKNKE--NMLYHQFDEKEKATNDIEQKIEDANKNIPNIEIAIHTSIYNII 1057
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1384 EELEEAKKKLAQRLQeaEEAVEAVNAKCSSLEKTKHRLQ----------------NEIEDLMVDVErsnaaaaALDKKQR 1447
Cdd:TIGR01612 1058 DEIEKEIGKNIELLN--KEILEEAEINITNFNEIKEKLKhynfddfgkeenikyaDEINKIKDDIK-------NLDQKID 1128
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1448 NFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKN--AYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHE 1525
Cdd:TIGR01612 1129 HHIKALEEIKKKSENYIDEIKAQINDLEDVADKAISNDDpeEIEKKIENIVTKIDKKKNIYDEIKKLLNEIAEIEKDKTS 1208
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1526 LEKVR---------------KQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKlaekdEEMEQAKRNH 1590
Cdd:TIGR01612 1209 LEEVKginlsygknlgklflEKIDEEKKKSEHMIKAMEAYIEDLDEIKEKSPEIENEMGIEMDIK-----AEMETFNISH 1283
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1591 LRVVDSLQTSLDAE---TRSRNEALRVKKKM--EGDLNEMEIQLshaNRMAAEAQKQVKSLQSLLKDTQ-----IQLDDA 1660
Cdd:TIGR01612 1284 DDDKDHHIISKKHDeniSDIREKSLKIIEDFseESDINDIKKEL---QKNLLDAQKHNSDINLYLNEIAniyniLKLNKI 1360
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1661 VRANDDLKENIAIVERRNNLLQAE----------------LEELRAVVEQTERSRKLAE--QELIETSERVQLLHSQNTS 1722
Cdd:TIGR01612 1361 KKIIDEVKEYTKEIEENNKNIKDEldkseklikkikddinLEECKSKIESTLDDKDIDEciKKIKELKNHILSEESNIDT 1440
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1723 LINQKKKMDADLSQLQTEVEEAVQECRN-AEEKAKKAITDAAMMAEELKKEQDTS-----------AHLERMKKNMEQTI 1790
Cdd:TIGR01612 1441 YFKNADENNENVLLLFKNIEMADNKSQHiLKIKKDNATNDHDFNINELKEHIDKSkgckdeadknaKAIEKNKELFEQYK 1520
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1791 KDLQHRLDEAEQIALKGG----KKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQD 1866
Cdd:TIGR01612 1521 KDVTELLNKYSALAIKNKfaktKKDSEIIIKEIKDAHKKFILEAEKSEQKIKEIKKEKFRIEDDAAKNDKSNKAAIDIQL 1600

                   ....*...
gi 124302198  1867 LVDKLQLK 1874
Cdd:TIGR01612 1601 SLENFENK 1608
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
847-1447 2.20e-07

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 56.50  E-value: 2.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  847 KEMASMKEEFTRLKEALEKSEARRKELEEKMVS------LLQEKNDLQLQVQAEQDNLADAEERcdqliknkiqLEakvk 920
Cdd:COG3096   299 RQLAEEQYRLVEMARELEELSARESDLEQDYQAasdhlnLVQTALRQQEKIERYQEDLEELTER----------LE---- 364
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  921 EMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDL-------------------------------ELTLAKVEKEKH 969
Cdd:COG3096   365 EQEEVVEEAAEQLAEAEARLEAAEEEVDSLKSQLADYqqaldvqqtraiqyqqavqalekaralcglpDLTPENAEDYLA 444
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  970 ATENKVKNLTEEMAGLDE--IIAKLTKEK--KALQ------------EAHQQALDDLQAEEDKVNTLTKAkVKLEQQVDD 1033
Cdd:COG3096   445 AFRAKEQQATEEVLELEQklSVADAARRQfeKAYElvckiageversQAWQTARELLRRYRSQQALAQRL-QQLRAQLAE 523
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1034 LEGSLEQEKKVRMDLERAKRKLEGDLkltqESIMDLENDKQQLDERLKKkdfelnaLNARIEDEQALGSQLQKKLKELQA 1113
Cdd:COG3096   524 LEQRLRQQQNAERLLEEFCQRIGQQL----DAAEELEELLAELEAQLEE-------LEEQAAEAVEQRSELRQQLEQLRA 592
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1114 RIEELEEELEAERTARAKVEKLRsdlsrelEEISERLEEAGGATS-VQIEMNKKREAEFQKmrrdlEEATLQHEATAAAL 1192
Cdd:COG3096   593 RIKELAARAPAWLAAQDALERLR-------EQSGEALADSQEVTAaMQQLLEREREATVER-----DELAARKQALESQI 660
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1193 RKKHADSVAE------LGEQ---------------------------------IDNLQRVKQKL---------------- 1217
Cdd:COG3096   661 ERLSQPGGAEdprllaLAERlggvllseiyddvtledapyfsalygparhaivVPDLSAVKEQLagledcpedlyliegd 740
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1218 -------------------------------------------EKEKSEFKLELDDVTsnmEQIIKAKANLEKMCRTLED 1254
Cdd:COG3096   741 pdsfddsvfdaeeledavvvklsdrqwrysrfpevplfgraarEKRLEELRAERDELA---EQYAKASFDVQKLQRLHQA 817
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1255 -------------------QMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTrgkL----TYTQQ 1311
Cdd:COG3096   818 fsqfvgghlavafapdpeaELAALRQRRSELERELAQHRAQEQQLRQQLDQLKEQLQLLNKLLPQAN---LladeTLADR 894
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1312 LEDLKRQLEEEVKAKNALAH-------------ALQSARHDCDLLREQYEeetEAKAELQRVLSK--ANSEVAQWRT--K 1374
Cdd:COG3096   895 LEELREELDAAQEAQAFIQQhgkalaqleplvaVLQSDPEQFEQLQADYL---QAKEQQRRLKQQifALSEVVQRRPhfS 971
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1375 YEtDAIQRTEELEEAKKKLAQRLQEAE-------EAVEAVNAKCS-------SLeKTKHR--------LQNEIEDLMVDV 1432
Cdd:COG3096   972 YE-DAVGLLGENSDLNEKLRARLEQAEearrearEQLRQAQAQYSqynqvlaSL-KSSRDakqqtlqeLEQELEELGVQA 1049
                         810
                  ....*....|....*
gi 124302198 1433 ErSNAAAAALDKKQR 1447
Cdd:COG3096  1050 D-AEAEERARIRRDE 1063
EzrA pfam06160
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ...
1481-1927 2.26e-07

Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation. The structure contains 5 spectrin like alpha helical repeats.


Pssm-ID: 428797 [Multi-domain]  Cd Length: 542  Bit Score: 55.63  E-value: 2.26e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1481 LFKLKNAYEEsLEHLETFKRE--NKNLQEEISDLtEQLGSSGKTIHELEKVRKQ---LEAEKM-ELQSALEEAEASLEhe 1554
Cdd:pfam06160    2 LLLRKKIYKE-IDELEERKNElmNLPVQEELSKV-KKLNLTGETQEKFEEWRKKwddIVTKSLpDIEELLFEAEELND-- 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1555 EGKILRAQLEFNqikaEIERKLAEKDEEMEQakrnhlrVVDSLQTSLDAETRSRNEALRVKKK----------------- 1617
Cdd:pfam06160   78 KYRFKKAKKALD----EIEELLDDIEEDIKQ-------ILEELDELLESEEKNREEVEELKDKyrelrktllanrfsygp 146
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1618 ----MEGDLNEMEIQLSHA-NRMAA----EAQKQVKSLQSLLKDTQIQLDDavranddlkenI-AIVERRNNLLQAELEE 1687
Cdd:pfam06160  147 aideLEKQLAEIEEEFSQFeELTESgdylEAREVLEKLEEETDALEELMED-----------IpPLYEELKTELPDQLEE 215
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1688 LRAVVEQTERSR-KLAEQELIETSERVQLLHSQNTSLINQK--KKMDADLSQLQTEVEEaVQECRNAEEKAKKaitdaam 1764
Cdd:pfam06160  216 LKEGYREMEEEGyALEHLNVDKEIQQLEEQLEENLALLENLelDEAEEALEEIEERIDQ-LYDLLEKEVDAKK------- 287
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1765 maeELKKEQDT-SAHLERMKKNMEQTIKDLQH-----RLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVK 1838
Cdd:pfam06160  288 ---YVEKNLPEiEDYLEHAEEQNKELKEELERvqqsyTLNENELERVRGLEKQLEELEKRYDEIVERLEEKEVAYSELQE 364
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1839 GMRKSERRIKELTYQTEEDRKNL-------LRLQDLVDKLQLKVKAYKRQAE----------------EAEEQANTNLSK 1895
Cdd:pfam06160  365 ELEEILEQLEEIEEEQEEFKESLqslrkdeLEAREKLDEFKLELREIKRLVEksnlpglpesyldyffDVSDEIEDLADE 444
                          490       500       510
                   ....*....|....*....|....*....|..
gi 124302198  1896 FRKVQHELDEAEERADIAESQVNKLRAKSRDI 1927
Cdd:pfam06160  445 LNEVPLNMDEVNRLLDEAQDDVDTLYEKTEEL 476
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
840-1097 2.46e-07

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 55.79  E-value: 2.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  840 LKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLlqeknDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKV 919
Cdd:COG3206   168 LRREEARKALEFLEEQLPELRKELEEAEAALEEFRQKNGLV-----DLSEEAKLLLQQLSELESQLAEARAELAEAEARL 242
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  920 KEMNERLEDEEEMNAELTAkkrklEDECSELKRDIDDLELTLAkvEKEKHATEN--KVKNLTEEMAGLdeiiakltkeKK 997
Cdd:COG3206   243 AALRAQLGSGPDALPELLQ-----SPVIQQLRAQLAELEAELA--ELSARYTPNhpDVIALRAQIAAL----------RA 305
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  998 ALQEAHQQALDDLQAEedkVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRklegDLKLTQESIMDLENDKQQLD 1077
Cdd:COG3206   306 QLQQEAQRILASLEAE---LEALQAREASLQAQLAQLEARLAELPELEAELRRLER----EVEVARELYESLLQRLEEAR 378
                         250       260
                  ....*....|....*....|
gi 124302198 1078 ERLkkkdfELNALNARIEDE 1097
Cdd:COG3206   379 LAE-----ALTVGNVRVIDP 393
PRK01156 PRK01156
chromosome segregation protein; Provisional
854-1231 2.62e-07

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 56.06  E-value: 2.62e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  854 EEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIK----NKIQLEAKVKEMNERLEDE 929
Cdd:PRK01156  342 IKKKSRYDDLNNQILELEGYEMDYNSYLKSIESLKKKIEEYSKNIERMSAFISEILKiqeiDPDAIKKELNEINVKLQDI 421
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  930 EEMNAELTAKKRKLEDECSELKRD-------------------------IDDLELTLAKVEKEKHATENKVKNLTEEMAG 984
Cdd:PRK01156  422 SSKVSSLNQRIRALRENLDELSRNmemlngqsvcpvcgttlgeeksnhiINHYNEKKSRLEEKIREIEIEVKDIDEKIVD 501
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  985 LDEIIAKLTKEKKALQEAHQQALDDLQAE----EDKVNTLTKAKVKLEQ--------QVDDLEGSLEQEKK--------- 1043
Cdd:PRK01156  502 LKKRKEYLESEEINKSINEYNKIESARADlediKIKINELKDKHDKYEEiknrykslKLEDLDSKRTSWLNalavislid 581
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1044 ---VRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNAR---IEDEQALGSQLQKKLKELQARIEE 1117
Cdd:PRK01156  582 ietNRSRSNEIKKQLNDLESRLQEIEIGFPDDKSYIDKSIREIENEANNLNNKyneIQENKILIEKLRGKIDNYKKQIAE 661
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1118 LEEELEAERTARAKVEKLRSDL---SRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRK 1194
Cdd:PRK01156  662 IDSIIPDLKEITSRINDIEDNLkksRKALDDAKANRARLESTIEILRTRINELSDRINDINETLESMKKIKKAIGDLKRL 741
                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 124302198 1195 KHADSVAELGEQI--DNLQRVKQKLEKEKSEFKLELDDV 1231
Cdd:PRK01156  742 REAFDKSGVPAMIrkSASQAMTSLTRKYLFEFNLDFDDI 780
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
1139-1791 2.63e-07

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 55.98  E-value: 2.63e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1139 LSRELEEISERLEEaggaTSVQIEMNKKR-EAEFQKMRRDLEeaTLQHEATAAALRKKHADSVAELGE---QIDNLQRVK 1214
Cdd:pfam10174  128 QAKELFLLRKTLEE----MELRIETQKQTlGARDESIKKLLE--MLQSKGLPKKSGEEDWERTRRIAEaemQLGHLEVLL 201
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1215 QKLEKEKSEFKLEL---------DDVTSNMEQIIKAK----ANLEKMCRTLEDQMNEHRSKA-------EETQRSVNDLT 1274
Cdd:pfam10174  202 DQKEKENIHLREELhrrnqlqpdPAKTKALQTVIEMKdtkiSSLERNIRDLEDEVQMLKTNGllhtedrEEEIKQMEVYK 281
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1275 SQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLE---EEVKAKNALAHALQSarhDCDLLREQYEEEt 1351
Cdd:pfam10174  282 SHSKFMKNKIDQLKQELSKKESELLALQTKLETLTNQNSDCKQHIEvlkESLTAKEQRAAILQT---EVDALRLRLEEK- 357
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1352 eakaelQRVLSKansevaqwrtkyETDAIQRteeLEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVD 1431
Cdd:pfam10174  358 ------ESFLNK------------KTKQLQD---LTEEKSTLAGEIRDLKDMLDVKERKINVLQKKIENLQEQLRDKDKQ 416
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1432 VERSNAAAAALDKKQRNFDKILAEWKQKyEESQSELESSQKEARSLSTElfklknayeESLEHLETFKRENKNLQEEISD 1511
Cdd:pfam10174  417 LAGLKERVKSLQTDSSNTDTALTTLEEA-LSEKERIIERLKEQREREDR---------ERLEELESLKKENKDLKEKVSA 486
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1512 LTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEH--EEGKILRAQLEFNQIKAEIERK---LAEKDEEMEQA 1586
Cdd:pfam10174  487 LQPELTEKESSLIDLKEHASSLASSGLKKDSKLKSLEIAVEQkkEECSKLENQLKKAHNAEEAVRTnpeINDRIRLLEQE 566
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1587 KRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQ-LDDAVRAND 1665
Cdd:pfam10174  567 VARYKEESGKAQAEVERLLGILREVENEKNDKDKKIAELESLTLRQMKEQNKKVANIKHGQQEMKKKGAQlLEEARRRED 646
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1666 DLKENIAiverrnnllQAELEELRAVVEQTersrklaEQELIETSERV----QLLHSQNTSLINQKKKMDADLSqlqtEV 1741
Cdd:pfam10174  647 NLADNSQ---------QLQLEELMGALEKT-------RQELDATKARLsstqQSLAEKDGHLTNLRAERRKQLE----EI 706
                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|.
gi 124302198  1742 EEAVQECRNAEEKAKKA-ITDAAMMAEELKKEQDTSAHLERMKKNMEQTIK 1791
Cdd:pfam10174  707 LEMKQEALLAAISEKDAnIALLELSSSKKKKTQEEVMALKREKDRLVHQLK 757
Crescentin pfam19220
Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament ...
921-1339 3.10e-07

Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament proteins, named crescentin, whose cytoskeletal function is required for the vibrioid and helical shapes of Caulobacter crescentus. Without crescentin, the cells adopt a straight-rod morphology. Crescentin has characteriztic features of IF proteins including the ability to assemble into filaments in vitro without energy or cofactor requirements. In vivo, crescentin forms a helical structure that colocalizes with the inner cell curvatures beneath the cytoplasmic membrane.


Pssm-ID: 437057 [Multi-domain]  Cd Length: 401  Bit Score: 55.07  E-value: 3.10e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   921 EMNERLEDEEEMNAELTAKKRKLEDECSEL---KRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKK 997
Cdd:pfam19220   14 EMADRLEDLRSLKADFSQLIEPIEAILRELpqaKSRLLELEALLAQERAAYGKLRRELAGLTRRLSAAEGELEELVARLA 93
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   998 ALQEAHQQAldDLQAEEDKVNTLTKakvklEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLD 1077
Cdd:pfam19220   94 KLEAALREA--EAAKEELRIELRDK-----TAQAEALERQLAAETEQNRALEEENKALREEAQAAEKALQRAEGELATAR 166
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1078 ERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARieeleeeleaERTARAKVEKLRSDLSRELEEiSERLEEAggat 1157
Cdd:pfam19220  167 ERLALLEQENRRLQALSEEQAAELAELTRRLAELETQ----------LDATRARLRALEGQLAAEQAE-RERAEAQ---- 231
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1158 svqiemnkkreaefqkmrRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRvKQKLEKEKSEFKLElddvtSNMEQ 1237
Cdd:pfam19220  232 ------------------LEEAVEAHRAERASLRMKLEALTARAAATEQLLAEAR-NQLRDRDEAIRAAE-----RRLKE 287
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1238 IIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKL----QTENGELSRQLDEKEAL---ISQLTR----GKL 1306
Cdd:pfam19220  288 ASIERDTLERRLAGLEADLERRTQQFQEMQRARAELEERAEMLtkalAAKDAALERAEERIASLsdrIAELTKrfevERA 367
                          410       420       430
                   ....*....|....*....|....*....|....
gi 124302198  1307 TYTQQLEDLKRQLEEEvKAKNALAH-ALQSARHD 1339
Cdd:pfam19220  368 ALEQANRRLKEELQRE-RAERALAQgALEIARES 400
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
1619-1836 3.19e-07

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 54.84  E-value: 3.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1619 EGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERS 1698
Cdd:COG3883    15 DPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERARA 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1699 rklAEQELIETSERVQLLHSQNTS-LINQKKKMDAdLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEqdtsa 1777
Cdd:COG3883    95 ---LYRSGGSVSYLDVLLGSESFSdFLDRLSALSK-IADADADLLEELKADKAELEAKKAELEAKLAELEALKAE----- 165
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 124302198 1778 hLERMKKNMEQTIKDLQHRLDEAEQialkggkkQLQKLEARVRELENELEAEQKRNAES 1836
Cdd:COG3883   166 -LEAAKAELEAQQAEQEALLAQLSA--------EEAAAEAQLAELEAELAAAEAAAAAA 215
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
841-1277 3.28e-07

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 55.50  E-value: 3.28e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   841 KSAEREkEMASMKE----EFTRLKEALEKSEA---RRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKI 913
Cdd:pfam05483  389 KSSELE-EMTKFKNnkevELEELKKILAEDEKlldEKKQFEKIAEELKGKEQELIFLLQAREKEIHDLEIQLTAIKTSEE 467
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   914 QLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLT 993
Cdd:pfam05483  468 HYLKEVEDLKTELEKEKLKNIELTAHCDKLLLENKELTQEASDMTLELKKHQEDIINCKKQEERMLKQIENLEEKEMNLR 547
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   994 KEKKALQEAHQQALDDLQAEEDKVntltkakvklEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDK 1073
Cdd:pfam05483  548 DELESVREEFIQKGDEVKCKLDKS----------EENARSIEYEVLKKEKQMKILENKCNNLKKQIENKNKNIEELHQEN 617
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1074 QQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELqarieeleeeleaERTARAKVEKLRSDLSRELEEISERLEEA 1153
Cdd:pfam05483  618 KALKKKGSAENKQLNAYEIKVNKLELELASAKQKFEEI-------------IDNYQKEIEDKKISEEKLLEEVEKAKAIA 684
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1154 GGATSVQIEMNKKREAEFQKMrrdleeatlqheataAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTS 1233
Cdd:pfam05483  685 DEAVKLQKEIDKRCQHKIAEM---------------VALMEKHKHQYDKIIEERDSELGLYKNKEQEQSSAKAALEIELS 749
                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....
gi 124302198  1234 NMeqiikaKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQR 1277
Cdd:pfam05483  750 NI------KAELLSLKKQLEIEKEEKEKLKMEAKENTAILKDKK 787
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
1668-1933 3.57e-07

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 55.46  E-value: 3.57e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1668 KENIAIVERRNNLLQAELEELRAVVE--QTERSRKLAEQELIETSERVQLlhsqnTSLINQKKKMDADLSQLQTEVEEAV 1745
Cdd:TIGR02169  176 LEELEEVEENIERLDLIIDEKRQQLErlRREREKAERYQALLKEKREYEG-----YELLKEKEALERQKEAIERQLASLE 250
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1746 QEcrnaEEKAKKAITDAAMMAEELKKEQDTSAhlERMKKNMEQTIKDLQHRLDEAEqialkggkKQLQKLEARVRELENE 1825
Cdd:TIGR02169  251 EE----LEKLTEEISELEKRLEEIEQLLEELN--KKIKDLGEEEQLRVKEKIGELE--------AEIASLERSIAEKERE 316
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1826 LEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDE 1905
Cdd:TIGR02169  317 LEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEK 396
                          250       260
                   ....*....|....*....|....*...
gi 124302198  1906 AEERADIAESQVNKLRAKSRDIGTKGLN 1933
Cdd:TIGR02169  397 LKREINELKRELDRLQEELQRLSEELAD 424
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1351-1587 4.99e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 54.00  E-value: 4.99e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1351 TEAKAELQRVLSKANSEVAQwrtkyetdAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMv 1430
Cdd:COG4942    19 ADAAAEAEAELEQLQQEIAE--------LEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELE- 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1431 dvERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEIS 1510
Cdd:COG4942    90 --KEIAELRAELEAQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRA 167
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 124302198 1511 DLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAK 1587
Cdd:COG4942   168 ELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTP 244
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
846-1013 5.18e-07

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 53.00  E-value: 5.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  846 EKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKiQLEAKVKEMner 925
Cdd:COG1579    23 EHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVRNNK-EYEALQKEI--- 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  926 ledeeemnAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKhatENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQ 1005
Cdd:COG1579    99 --------ESLKRRISDLEDEILELMERIEELEEELAELEAEL---AELEAELEEKKAELDEELAELEAELEELEAEREE 167

                  ....*...
gi 124302198 1006 ALDDLQAE 1013
Cdd:COG1579   168 LAAKIPPE 175
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
1001-1162 6.18e-07

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 52.62  E-value: 6.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1001 EAHQQALDDLQAEEDKVNTLTKAK-------VKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESImdlENDK 1073
Cdd:COG1579     3 PEDLRALLDLQELDSELDRLEHRLkelpaelAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARI---KKYE 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1074 QQLDERLKKKdfELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEA 1153
Cdd:COG1579    80 EQLGNVRNNK--EYEALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAE 157

                  ....*....
gi 124302198 1154 GGATSVQIE 1162
Cdd:COG1579   158 LEELEAERE 166
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
835-1200 8.52e-07

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 54.35  E-value: 8.52e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   835 KIKPLLKSAEREKEM-ASMKEEFTRLKEALEKSE-------------ARRKELEEKMVSLLQEKNDLQLQ----VQAEQD 896
Cdd:pfam15921  462 KVSSLTAQLESTKEMlRKVVEELTAKKMTLESSErtvsdltaslqekERAIEATNAEITKLRSRVDLKLQelqhLKNEGD 541
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   897 NLADAEERCDQLiknKIQLEAK---VKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATEN 973
Cdd:pfam15921  542 HLRNVQTECEAL---KLQMAEKdkvIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRLELQEFKILKDKKDA 618
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   974 KVKNLTEEMAGLDEIIAKLT-------KEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQE-KKVR 1045
Cdd:pfam15921  619 KIRELEARVSDLELEKVKLVnagserlRAVKDIKQERDQLLNEVKTSRNELNSLSEDYEVLKRNFRNKSEEMETTtNKLK 698
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1046 MDLERAKRKLEGdlklTQESIMDLENDkqqlderlkkkdfELNALNARIEDEQALGSQlQKKLKELQARIEELEEELEAE 1125
Cdd:pfam15921  699 MQLKSAQSELEQ----TRNTLKSMEGS-------------DGHAMKVAMGMQKQITAK-RGQIDALQSKIQFLEEAMTNA 760
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 124302198  1126 RTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSV 1200
Cdd:pfam15921  761 NKEKHFLKEEKNKLSQELSTVATEKNKMAGELEVLRSQERRLKEKVANMEVALDKASLQFAECQDIIQRQEQESV 835
PLN02939 PLN02939
transferase, transferring glycosyl groups
841-1111 1.41e-06

transferase, transferring glycosyl groups


Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 53.75  E-value: 1.41e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  841 KSAEREKEMASMKEEFTRLKEALEKS-----EARRKELEEkMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKI-- 913
Cdd:PLN02939  118 NSKDGEQLSDFQLEDLVGMIQNAEKNilllnQARLQALED-LEKILTEKEALQGKINILEMRLSETDARIKLAAQEKIhv 196
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  914 -----QLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKekhaTENKVKNLTEEMAGLDEI 988
Cdd:PLN02939  197 eileeQLEKLRNELLIRGATEGLCVHSLSKELDVLKEENMLLKDDIQFLKAELIEVAE----TEERVFKLEKERSLLDAS 272
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  989 IAKLTKEKKALQEAHQQaLDDLQAEE--DKVNTLTKAKVKLEQQVDDLEGSLEQEKkvrmDLERAKRKLEGDL------K 1060
Cdd:PLN02939  273 LRELESKFIVAQEDVSK-LSPLQYDCwwEKVENLQDLLDRATNQVEKAALVLDQNQ----DLRDKVDKLEASLkeanvsK 347
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 124302198 1061 LTQESIMDLENDKQQLDERLKKKDFElnaLNARIEDEQALGSQLQKKLKEL 1111
Cdd:PLN02939  348 FSSYKVELLQQKLKLLEERLQASDHE---IHSYIQLYQESIKEFQDTLSKL 395
mukB PRK04863
chromosome partition protein MukB;
1042-1868 1.85e-06

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 53.42  E-value: 1.85e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1042 KKVRMDLERAKRKLegdlKLTQESIMDLENDKQQLDERLKK------KDFELNALNARIEDEQALGSQlqkklKELQAri 1115
Cdd:PRK04863  229 RKAFQDMEAALREN----RMTLEAIRVTQSDRDLFKHLITEstnyvaADYMRHANERRVHLEEALELR-----RELYT-- 297
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1116 eeleeeleaERTARAKVEKLRSDLSRELEEISER---LEEAGGATS--VQIEMNKKREAE-FQKMRRDLEEATLQHEATA 1189
Cdd:PRK04863  298 ---------SRRQLAAEQYRLVEMARELAELNEAesdLEQDYQAASdhLNLVQTALRQQEkIERYQADLEELEERLEEQN 368
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1190 AAlrkkhadsVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNME-------QIIKAKANLEK---MCRT-------L 1252
Cdd:PRK04863  369 EV--------VEEADEQQEENEARAEAAEEEVDELKSQLADYQQALDvqqtraiQYQQAVQALERakqLCGLpdltadnA 440
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1253 EDQMNEHRSKAEETQRSVNDL-----TSQRAKLQTENG---------------------ELSRQLDEKEALISQLTRGKl 1306
Cdd:PRK04863  441 EDWLEEFQAKEQEATEELLSLeqklsVAQAAHSQFEQAyqlvrkiagevsrseawdvarELLRRLREQRHLAEQLQQLR- 519
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1307 tytQQLEDLKRQLEEEVKAKNALAHALQSARHDCDlLREQYEEETEAKAELQRVLSKANSEVAQWRTKYEtdaiQRTEEL 1386
Cdd:PRK04863  520 ---MRLSELEQRLRQQQRAERLLAEFCKRLGKNLD-DEDELEQLQEELEARLESLSESVSEARERRMALR----QQLEQL 591
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1387 EEAKKKLAQRLQE---AEEAVEAVNAKCSSLEKTKHRLQNEIEDLmvdVERSNAAAAALDKKQRNFDKILAEWKQKYEES 1463
Cdd:PRK04863  592 QARIQRLAARAPAwlaAQDALARLREQSGEEFEDSQDVTEYMQQL---LERERELTVERDELAARKQALDEEIERLSQPG 668
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1464 QSELESSQKEARSLSTELfkLKNAYEE-SLEH-------------------LETFKRENKNLQEEISDL------TEQLG 1517
Cdd:PRK04863  669 GSEDPRLNALAERFGGVL--LSEIYDDvSLEDapyfsalygparhaivvpdLSDAAEQLAGLEDCPEDLyliegdPDSFD 746
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1518 SSGKTIHELEK----------VR----------------KQLEAEKMELQSaLEEAEASLEHEEGKILRAQLEFNQIKAE 1571
Cdd:PRK04863  747 DSVFSVEELEKavvvkiadrqWRysrfpevplfgraareKRIEQLRAEREE-LAERYATLSFDVQKLQRLHQAFSRFIGS 825
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1572 -IERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMeiqLSHANRMAAEaqkqvkSLQSLL 1650
Cdd:PRK04863  826 hLAVAFEADPEAELRQLNRRRVELERALADHESQEQQQRSQLEQAKEGLSALNRL---LPRLNLLADE------TLADRV 896
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1651 KDTQIQLDDAVRANDDLKEN---IAIVERRNNLLQA---ELEELRAVVEQTERSRKLAEQELIETSERVQLLH----SQN 1720
Cdd:PRK04863  897 EEIREQLDEAEEAKRFVQQHgnaLAQLEPIVSVLQSdpeQFEQLKQDYQQAQQTQRDAKQQAFALTEVVQRRAhfsyEDA 976
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1721 TSLINQkkkmDADLS-QLQTEVEEAVQECRNAEEKAKKA---ITDAAMMAEELKKEQDTsahLERMKKNMEQTIKDLQHR 1796
Cdd:PRK04863  977 AEMLAK----NSDLNeKLRQRLEQAEQERTRAREQLRQAqaqLAQYNQVLASLKSSYDA---KRQMLQELKQELQDLGVP 1049
                         890       900       910       920       930       940       950
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 124302198 1797 LDEAEQIALKGGKKQLQKLEARVRELENELEAE---QKRNAES-VKGMRKSERRIKELTYQTEEDRKNLLRLQDLV 1868
Cdd:PRK04863 1050 ADSGAEERARARRDELHARLSANRSRRNQLEKQltfCEAEMDNlTKKLRKLERDYHEMREQVVNAKAGWCAVLRLV 1125
Crescentin pfam19220
Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament ...
1473-1829 1.89e-06

Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament proteins, named crescentin, whose cytoskeletal function is required for the vibrioid and helical shapes of Caulobacter crescentus. Without crescentin, the cells adopt a straight-rod morphology. Crescentin has characteriztic features of IF proteins including the ability to assemble into filaments in vitro without energy or cofactor requirements. In vivo, crescentin forms a helical structure that colocalizes with the inner cell curvatures beneath the cytoplasmic membrane.


Pssm-ID: 437057 [Multi-domain]  Cd Length: 401  Bit Score: 52.38  E-value: 1.89e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1473 EARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLE 1552
Cdd:pfam19220   21 DLRSLKADFSQLIEPIEAILRELPQAKSRLLELEALLAQERAAYGKLRRELAGLTRRLSAAEGELEELVARLAKLEAALR 100
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1553 HEEGKILRAQLEFNQ---IKAEIERKLAEKDEEME------QAKRNHLRVVDSLQTSLDAETRSRNEALRV----KKKME 1619
Cdd:pfam19220  101 EAEAAKEELRIELRDktaQAEALERQLAAETEQNRaleeenKALREEAQAAEKALQRAEGELATARERLALleqeNRRLQ 180
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1620 GDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAV----RANDDLKENIAIVERRNNLLQAELEELRAVVEQT 1695
Cdd:pfam19220  181 ALSEEQAAELAELTRRLAELETQLDATRARLRALEGQLAAEQaereRAEAQLEEAVEAHRAERASLRMKLEALTARAAAT 260
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1696 ERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQEcRNAEEKAKKAITD-AAMMAEELKkeqD 1774
Cdd:pfam19220  261 EQLLAEARNQLRDRDEAIRAAERRLKEASIERDTLERRLAGLEADLERRTQQ-FQEMQRARAELEErAEMLTKALA---A 336
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 124302198  1775 TSAHLERMkknmEQTIKDLQHRLDEAEQIALKggkkQLQKLEARVRELENELEAE 1829
Cdd:pfam19220  337 KDAALERA----EERIASLSDRIAELTKRFEV----ERAALEQANRRLKEELQRE 383
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
934-1130 2.71e-06

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 51.75  E-value: 2.71e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  934 AELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQ-- 1011
Cdd:COG3883    19 QAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERARALYrs 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1012 -AEEDKVNTLTKAK---------VKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLK 1081
Cdd:COG3883    99 gGSVSYLDVLLGSEsfsdfldrlSALSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKAELEAQQA 178
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 124302198 1082 KKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARA 1130
Cdd:COG3883   179 EQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAA 227
Macoilin pfam09726
Macoilin family; The Macoilin proteins has an N-terminal portion that is composed of 5 ...
1245-1446 2.83e-06

Macoilin family; The Macoilin proteins has an N-terminal portion that is composed of 5 trasnmembrane helices, followed by a C-terminal coiled-coil region. Macoilin is a highly conserved protein present in eukaryotes. Macoilin appears to be found in the ER and be involved in the function of neurons.


Pssm-ID: 462859 [Multi-domain]  Cd Length: 670  Bit Score: 52.55  E-value: 2.83e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1245 LEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVK 1324
Cdd:pfam09726  400 LEQDIKKLKAELQASRQTEQELRSQISSLTSLERSLKSELGQLRQENDLLQTKLHNAVSAKQKDKQTVQQLEKRLKAEQE 479
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1325 AKNALAHALQSARHdcdllREQYEEETEAKAELQRVLSKANSevaqwrtkyeTDAI-QRTEELEEAKKKLAQRLQEAEEA 1403
Cdd:pfam09726  480 ARASAEKQLAEEKK-----RKKEEEATAARAVALAAASRGEC----------TESLkQRKRELESEIKKLTHDIKLKEEQ 544
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 124302198  1404 VEAVNAKCSSLEKTKHRlQNEIEDLMvdversNAAAAALDKKQ 1446
Cdd:pfam09726  545 IRELEIKVQELRKYKES-EKDTEVLM------SALSAMQDKNQ 580
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
1056-1286 3.40e-06

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 51.75  E-value: 3.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1056 EGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEeleeeleaerTARAKVEKL 1135
Cdd:COG3883    15 DPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIA----------EAEAEIEER 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1136 RSDLSRELEEISERLEEAG------GATSV-----QIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKhadsVAELG 1204
Cdd:COG3883    85 REELGERARALYRSGGSVSyldvllGSESFsdfldRLSALSKIADADADLLEELKADKAELEAKKAELEAK----LAELE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1205 EQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTEN 1284
Cdd:COG3883   161 ALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA 240

                  ..
gi 124302198 1285 GE 1286
Cdd:COG3883   241 AA 242
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
845-1835 3.54e-06

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 52.36  E-value: 3.54e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   845 REKEMASMKEEFTRLKEALEKSEARRKELeekmvsllqeKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNE 924
Cdd:TIGR01612  763 KEKELSNKINDYAKEKDELNKYKSKISEI----------KNHYNDQINIDNIKDEDAKQNYDKSKEYIKTISIKEDEIFK 832
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   925 RLEDEEEMNAELTAKKRK---LEDECSElkrDIDDLELTLAKVEkekhateNKVKNLTEEmAGLDEIIAKLTKEKKALQE 1001
Cdd:TIGR01612  833 IINEMKFMKDDFLNKVDKfinFENNCKE---KIDSEHEQFAELT-------NKIKAEISD-DKLNDYEKKFNDSKSLINE 901
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1002 AHQQalddLQAEEDKVNTLTKakvkLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLK 1081
Cdd:TIGR01612  902 INKS----IEEEYQNINTLKK----VDEYIKICENTKESIEKFHNKQNILKEILNKNIDTIKESNLIEKSYKDKFDNTLI 973
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1082 KKDFELNAL--NARIEDEQALGSQLQKKLKELQARIEELEEEL-----EAERTARAKVEKLRSDLSRELEEI-------- 1146
Cdd:TIGR01612  974 DKINELDKAfkDASLNDYEAKNNELIKYFNDLKANLGKNKENMlyhqfDEKEKATNDIEQKIEDANKNIPNIeiaihtsi 1053
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1147 ---SERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSE 1223
Cdd:TIGR01612 1054 yniIDEIEKEIGKNIELLNKEILEEAEINITNFNEIKEKLKHYNFDDFGKEENIKYADEINKIKDDIKNLDQKIDHHIKA 1133
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1224 FKlELDDVTSNMEQIIKAKAN-LEKMCRTLedQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLT 1302
Cdd:TIGR01612 1134 LE-EIKKKSENYIDEIKAQINdLEDVADKA--ISNDDPEEIEKKIENIVTKIDKKKNIYDEIKKLLNEIAEIEKDKTSLE 1210
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1303 RGK---LTYTQQLEDL-KRQLEEEVKAKNALAHALQSARHDCDLLREQYEE-------ETEAKAELQrVLSKANSEvaqw 1371
Cdd:TIGR01612 1211 EVKginLSYGKNLGKLfLEKIDEEKKKSEHMIKAMEAYIEDLDEIKEKSPEienemgiEMDIKAEME-TFNISHDD---- 1285
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1372 RTKYETDAIQRTEELEEAKKKLAQRLQEaeeaveavNAKCSSLEKTKHRLQNEIedlmVDVERSNAAAAALDKKQRNFDK 1451
Cdd:TIGR01612 1286 DKDHHIISKKHDENISDIREKSLKIIED--------FSEESDINDIKKELQKNL----LDAQKHNSDINLYLNEIANIYN 1353
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1452 ILaewkqkyeesqselessqkearslstELFKLKNAYEESLEHLETFKRENKNLQEEISDlTEQLGssgKTIHElekvRK 1531
Cdd:TIGR01612 1354 IL--------------------------KLNKIKKIIDEVKEYTKEIEENNKNIKDELDK-SEKLI---KKIKD----DI 1399
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1532 QLEAEKMELQSALEEAEAsleheEGKILRAQLEFNQIKAEierkLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNeA 1611
Cdd:TIGR01612 1400 NLEECKSKIESTLDDKDI-----DECIKKIKELKNHILSE----ESNIDTYFKNADENNENVLLLFKNIEMADNKSQH-I 1469
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1612 LRVKKK-----MEGDLNEMEIQLSHANRMAAEAQKQVKSLQS---LLKdtQIQLDDAVRAND----DLKENIAIVERRNN 1679
Cdd:TIGR01612 1470 LKIKKDnatndHDFNINELKEHIDKSKGCKDEADKNAKAIEKnkeLFE--QYKKDVTELLNKysalAIKNKFAKTKKDSE 1547
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1680 LLQAELEELRAVV----EQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQ--TEVEEAVQECRNAEE 1753
Cdd:TIGR01612 1548 IIIKEIKDAHKKFileaEKSEQKIKEIKKEKFRIEDDAAKNDKSNKAAIDIQLSLENFENKFLkiSDIKKKINDCLKETE 1627
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1754 KAKKAITDAAMMAEE--LKKEQDTSAHLERMKKNMEQTIKDLQHRldeaeqialkggKKQLQKLEARVRELENELEaEQK 1831
Cdd:TIGR01612 1628 SIEKKISSFSIDSQDteLKENGDNLNSLQEFLESLKDQKKNIEDK------------KKELDELDSEIEKIEIDVD-QHK 1694

                   ....
gi 124302198  1832 RNAE 1835
Cdd:TIGR01612 1695 KNYE 1698
PRK01156 PRK01156
chromosome segregation protein; Provisional
883-1531 3.55e-06

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 52.21  E-value: 3.55e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  883 EKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELtakkRKLEDECSELKRDIDDLELTLA 962
Cdd:PRK01156  139 EMDSLISGDPAQRKKILDEILEINSLERNYDKLKDVIDMLRAEISNIDYLEEKL----KSSNLELENIKKQIADDEKSHS 214
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  963 KVEKEKHATENKVKNLTEEMAGLDEIIAKLT---KEKKALQEAHQQALDDLQAEEDKVNtltkakvkleqqvdDLEGSLE 1039
Cdd:PRK01156  215 ITLKEIERLSIEYNNAMDDYNNLKSALNELSsleDMKNRYESEIKTAESDLSMELEKNN--------------YYKELEE 280
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1040 QEKKVRMDLERAKRklegdlkltqESIMDLENDKQQLD---ERLKKKDFELNALNARIedeqalgsqlqKKLKELQArie 1116
Cdd:PRK01156  281 RHMKIINDPVYKNR----------NYINDYFKYKNDIEnkkQILSNIDAEINKYHAII-----------KKLSVLQK--- 336
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1117 eleeeleaERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRR---DLEEATLQHEATAAALR 1193
Cdd:PRK01156  337 --------DYNDYIKKKSRYDDLNNQILELEGYEMDYNSYLKSIESLKKKIEEYSKNIERmsaFISEILKIQEIDPDAIK 408
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1194 KKHadsvAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEqiIKAKANLEKMCRT------LEDQMNEHRSKAEETQ 1267
Cdd:PRK01156  409 KEL----NEINVKLQDISSKVSSLNQRIRALRENLDELSRNME--MLNGQSVCPVCGTtlgeekSNHIINHYNEKKSRLE 482
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1268 RSVNDLTSQRAKLqteNGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQY 1347
Cdd:PRK01156  483 EKIREIEIEVKDI---DEKIVDLKKRKEYLESEEINKSINEYNKIESARADLEDIKIKINELKDKHDKYEEIKNRYKSLK 559
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1348 EEETEAKAElqrVLSKANSEvaqwRTKYETDAIQ-RTEELEEAKKKLAQRLQEAEEAVEAVNakcSSLEKTKHRLQNEIE 1426
Cdd:PRK01156  560 LEDLDSKRT---SWLNALAV----ISLIDIETNRsRSNEIKKQLNDLESRLQEIEIGFPDDK---SYIDKSIREIENEAN 629
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1427 DLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKeARSLSTELFKLKNAYEESLEHLETFKRENKNLQ 1506
Cdd:PRK01156  630 NLNNKYNEIQENKILIEKLRGKIDNYKKQIAEIDSIIPDLKEITSR-INDIEDNLKKSRKALDDAKANRARLESTIEILR 708
                         650       660
                  ....*....|....*....|....*
gi 124302198 1507 EEISDLTEQLGSSGKTIHELEKVRK 1531
Cdd:PRK01156  709 TRINELSDRINDINETLESMKKIKK 733
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
1668-1925 3.77e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 52.37  E-value: 3.77e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1668 KENIAIVE--RRNNLLQAELEELRAVVEQ-------TERsRKLAEQELIETSERVQLLHSQNTSLINQKKKMdadlsQLQ 1738
Cdd:TIGR02168  135 KRSYSIIEqgKISEIIEAKPEERRAIFEEaagiskyKER-RKETERKLERTRENLDRLEDILNELERQLKSL-----ERQ 208
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1739 TEVEEAVQECRNAEEKAKKAItdAAMMAEELKKEQDTsahLERMKKNMEQTIKDLQHRLDEAEQialkggkkQLQKLEAR 1818
Cdd:TIGR02168  209 AEKAERYKELKAELRELELAL--LVLRLEELREELEE---LQEELKEAEEELEELTAELQELEE--------KLEELRLE 275
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1819 VRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRK 1898
Cdd:TIGR02168  276 VSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELES 355
                          250       260
                   ....*....|....*....|....*..
gi 124302198  1899 VQHELDEAEERADIAESQVNKLRAKSR 1925
Cdd:TIGR02168  356 LEAELEELEAELEELESRLEELEEQLE 382
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
1251-1409 4.10e-06

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 49.92  E-value: 4.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1251 TLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAK--NA 1328
Cdd:COG1579    14 ELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVRNNKeyEA 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1329 LAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVN 1408
Cdd:COG1579    94 LQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAEREELAAKIP 173

                  .
gi 124302198 1409 A 1409
Cdd:COG1579   174 P 174
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1484-1935 4.35e-06

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 51.69  E-value: 4.35e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1484 LKNAYEESLEHLETFK-RENKNLQEEISDLTEQL---GSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEgkIL 1559
Cdd:COG4717    47 LLERLEKEADELFKPQgRKPELNLKELKELEEELkeaEEKEEEYAELQEELEELEEELEELEAELEELREELEKLE--KL 124
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1560 RAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEA 1639
Cdd:COG4717   125 LQLLPLYQELEALEAELAELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEEL 204
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1640 QKQVKSLQSLLKDTQIQLDDavranddlkeniaiverrnnlLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQ 1719
Cdd:COG4717   205 QQRLAELEEELEEAQEELEE---------------------LEEELEQLENELEAAALEERLKEARLLLLIAAALLALLG 263
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1720 NTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKK--EQDTSAHLERMKKNMEQTIKDLQHRL 1797
Cdd:COG4717   264 LGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALEEleEEELEELLAALGLPPDLSPEELLELL 343
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1798 DEAEQIalkggKKQLQKLEARVRELE-NELEAEQKRNAESVKGmrKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVK 1876
Cdd:COG4717   344 DRIEEL-----QELLREAEELEEELQlEELEQEIAALLAEAGV--EDEEELRAALEQAEEYQELKEELEELEEQLEELLG 416
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 124302198 1877 AYKRQAEEAEEQANTnlSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGTKGLNEE 1935
Cdd:COG4717   417 ELEELLEALDEEELE--EELEELEEELEELEEELEELREELAELEAELEQLEEDGELAE 473
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
1273-1697 5.38e-06

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 51.05  E-value: 5.38e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1273 LTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAknaLAHALQSARHDCDLLREQYEEETE 1352
Cdd:pfam07888   32 LQNRLEECLQERAELLQAQEAANRQREKEKERYKRDREQWERQRRELESRVAE---LKEELRQSREKHEELEEKYKELSA 108
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1353 AKAELqrvlskanSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDV 1432
Cdd:pfam07888  109 SSEEL--------SEEKDALLAQRAAHEARIRELEEDIKTLTQRVLERETELERMKERAKKAGAQRKEEEAERKQLQAKL 180
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1433 ERSnaaaaaldkkqrnfdkilaewkqkyeesqselessQKEARSLSTELFKLKNAYEESLEHLETfkrenknLQEEISDL 1512
Cdd:pfam07888  181 QQT-----------------------------------EEELRSLSKEFQELRNSLAQRDTQVLQ-------LQDTITTL 218
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1513 TEQLGSSGKTIHELEKVRKqleaekmELQSALEEAEASLEHEEGkilraqlefnqIKAEIERKLAEKDEEMEQAKRNHLR 1592
Cdd:pfam07888  219 TQKLTTAHRKEAENEALLE-------ELRSLQERLNASERKVEG-----------LGEELSSMAAQRDRTQAELHQARLQ 280
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1593 VVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQ--------------IQLD 1658
Cdd:pfam07888  281 AAQLTLQLADASLALREGRARWAQERETLQQSAEADKDRIEKLSAELQRLEERLQEERMEREklevelgrekdcnrVQLS 360
                          410       420       430
                   ....*....|....*....|....*....|....*....
gi 124302198  1659 DAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTER 1697
Cdd:pfam07888  361 ESRRELQELKASLRVAQKEKEQLQAEKQELLEYIRQLEQ 399
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
1261-1588 5.49e-06

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 51.55  E-value: 5.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1261 SKAEETQRSVNDLTsqRAKLQTENGELSRQLDEKE-----ALISQLTRGKLTYTQQLEDLKRQLEEEV--KAKNALAHAL 1333
Cdd:NF033838   50 SSGNESQKEHAKEV--ESHLEKILSEIQKSLDKRKhtqnvALNKKLSDIKTEYLYELNVLKEKSEAELtsKTKKELDAAF 127
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1334 QSARHDCDLLREQYEEETEAKAELQRvlsKANSEVAQWRTKYETDAIqRTEELEEAKKKLaqRLQEAEEAVEAVNAKCSS 1413
Cdd:NF033838  128 EQFKKDTLEPGKKVAEATKKVEEAEK---KAKDQKEEDRRNYPTNTY-KTLELEIAESDV--EVKKAELELVKEEAKEPR 201
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1414 LEKTkhrlqneIEDLMVDVERSNAAAAALDKKQRnfDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLE 1493
Cdd:NF033838  202 DEEK-------IKQAKAKVESKKAEATRLEKIKT--DREKAEEEAKRRADAKLKEAVEKNVATSEQDKPKRRAKRGVLGE 272
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1494 HLETFKRENKNLQEEISDLTEQLGS----SGKTIHELEK-----------------------VRKQLEAEKMELQSALEE 1546
Cdd:NF033838  273 PATPDKKENDAKSSDSSVGEETLPSpslkPEKKVAEAEKkveeakkkakdqkeedrrnyptnTYKTLELEIAESDVKVKE 352
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 124302198 1547 AEASLEHEEGKILRAQLEFNQIKAEIERKLAE----------KDEEMEQAKR 1588
Cdd:NF033838  353 AELELVKEEAKEPRNEEKIKQAKAKVESKKAEatrlekiktdRKKAEEEAKR 404
PRK10246 PRK10246
exonuclease subunit SbcC; Provisional
1236-1884 7.30e-06

exonuclease subunit SbcC; Provisional


Pssm-ID: 182330 [Multi-domain]  Cd Length: 1047  Bit Score: 51.34  E-value: 7.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1236 EQIIKAKANLEKmcrtLEDQMNEHRSKAEETQRSVND----LTSQRAKLQTENGELSRQ---LDEKEALISQLTRgklty 1308
Cdd:PRK10246  191 EQHKSARTELEK----LQAQASGVALLTPEQVQSLTAslqvLTDEEKQLLTAQQQQQQSlnwLTRLDELQQEASR----- 261
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1309 TQQLedLKRQLEEEVKAKNALAhALQSARHDCDL--LREQYEEETEAKAELQRVLSKANS---EVAQWRTKYETDAIQRT 1383
Cdd:PRK10246  262 RQQA--LQQALAAEEKAQPQLA-ALSLAQPARQLrpHWERIQEQSAALAHTRQQIEEVNTrlqSTMALRARIRHHAAKQS 338
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1384 EELEEAKKKLAQRLQEAE------EAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNA------------AAAALDK- 1444
Cdd:PRK10246  339 AELQAQQQSLNTWLAEHDrfrqwnNELAGWRAQFSQQTSDREQLRQWQQQLTHAEQKLNAlpaitltltadeVAAALAQh 418
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1445 -KQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKnayeeslEHLETFKRENKNLQEEISDLteqlgssgKTI 1523
Cdd:PRK10246  419 aEQRPLRQRLVALHGQIVPQQKRLAQLQVAIQNVTQEQTQRN-------AALNEMRQRYKEKTQQLADV--------KTI 483
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1524 HELEKVRKQLEAEKMELQS-------------------------------ALEEAEASLEhEEGKILRAQLE--FNQIK- 1569
Cdd:PRK10246  484 CEQEARIKDLEAQRAQLQAgqpcplcgstshpaveayqalepgvnqsrldALEKEVKKLG-EEGAALRGQLDalTKQLQr 562
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1570 --------AEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEgdlneMEIQLshanrmaAEAQK 1641
Cdd:PRK10246  563 deseaqslRQEEQALTQQWQAVCASLNITLQPQDDIQPWLDAQEEHERQLRLLSQRHE-----LQGQI-------AAHNQ 630
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1642 QVKSLQSLLKDTQIQLDDAVRA-----NDDLKENIAIVER------------RNNLLQAELEELRAVVEQTERSRKLAEQ 1704
Cdd:PRK10246  631 QIIQYQQQIEQRQQQLLTALAGyaltlPQEDEEASWLATRqqeaqswqqrqnELTALQNRIQQLTPLLETLPQSDDLPHS 710
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1705 ELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEK---AKKAITDAAMMAEElkkeqdTSAHLER 1781
Cdd:PRK10246  711 EETVALDNWRQVHEQCLSLHSQLQTLQQQDVLEAQRLQKAQAQFDTALQAsvfDDQQAFLAALLDEE------TLTQLEQ 784
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1782 MKKNMEQTIKDLQHRLDEAEQialkggkKQLQKLEARVRELENELEAE--QKRNAESVKGMRKSERRIKELTYQTEEDRK 1859
Cdd:PRK10246  785 LKQNLENQRQQAQTLVTQTAQ-------ALAQHQQHRPDGLDLTVTVEqiQQELAQLAQQLRENTTRQGEIRQQLKQDAD 857
                         730       740
                  ....*....|....*....|....*
gi 124302198 1860 NLLRLQDLVdklqLKVKAYKRQAEE 1884
Cdd:PRK10246  858 NRQQQQALM----QQIAQATQQVED 878
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1437-1677 7.65e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 50.53  E-value: 7.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1437 AAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQl 1516
Cdd:COG4942    13 LAAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKE- 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1517 gssgktiheLEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQI--KAEIERKLAEKDEEMEQAKRNHLRVV 1594
Cdd:COG4942    92 ---------IAELRAELEAQKEELAELLRALYRLGRQPPLALLLSPEDFLDAvrRLQYLKYLAPARREQAEELRADLAEL 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1595 DSLQTSLDAEtrsrnealrvKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIV 1674
Cdd:COG4942   163 AALRAELEAE----------RAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARL 232

                  ...
gi 124302198 1675 ERR 1677
Cdd:COG4942   233 EAE 235
PRK10246 PRK10246
exonuclease subunit SbcC; Provisional
849-1321 7.94e-06

exonuclease subunit SbcC; Provisional


Pssm-ID: 182330 [Multi-domain]  Cd Length: 1047  Bit Score: 50.95  E-value: 7.94e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  849 MASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQliknkiqleakvkemNERLED 928
Cdd:PRK10246  428 LVALHGQIVPQQKRLAQLQVAIQNVTQEQTQRNAALNEMRQRYKEKTQQLADVKTICEQ---------------EARIKD 492
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  929 EEEMNAELTAKK----------------RKLEDECSELKRdiDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKL 992
Cdd:PRK10246  493 LEAQRAQLQAGQpcplcgstshpaveayQALEPGVNQSRL--DALEKEVKKLGEEGAALRGQLDALTKQLQRDESEAQSL 570
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  993 TKEKKALQEAHQQALDDL---QAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRmDLERAKRKLEGDLKLTQESimdL 1069
Cdd:PRK10246  571 RQEEQALTQQWQAVCASLnitLQPQDDIQPWLDAQEEHERQLRLLSQRHELQGQIA-AHNQQIIQYQQQIEQRQQQ---L 646
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1070 ENDKQQLDERLKKKDFELNALNARiEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISER 1149
Cdd:PRK10246  647 LTALAGYALTLPQEDEEASWLATR-QQEAQSWQQRQNELTALQNRIQQLTPLLETLPQSDDLPHSEETVALDNWRQVHEQ 725
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1150 leeaggATSVQIEMNKKREAEFQKMRRdLEEATLQHEATAAALRkkHADSVAELG-----EQIDNLQRVKQKLEKeksef 1224
Cdd:PRK10246  726 ------CLSLHSQLQTLQQQDVLEAQR-LQKAQAQFDTALQASV--FDDQQAFLAalldeETLTQLEQLKQNLEN----- 791
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1225 klelddvtsnmeQIIKAKANLEKMCRTLEDQMN------EHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALI 1298
Cdd:PRK10246  792 ------------QRQQAQTLVTQTAQALAQHQQhrpdglDLTVTVEQIQQELAQLAQQLRENTTRQGEIRQQLKQDADNR 859
                         490       500
                  ....*....|....*....|...
gi 124302198 1299 SQLtrgkLTYTQQLEDLKRQLEE 1321
Cdd:PRK10246  860 QQQ----QALMQQIAQATQQVED 878
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
1349-1909 8.30e-06

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 50.88  E-value: 8.30e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1349 EETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKL-AQR--LQEAEEAVEAVNAKCSSLEKTKHRL--QN 1423
Cdd:pfam05483   71 ENSEGLSRLYSKLYKEAEKIKKWKVSIEAELKQKENKLQENRKIIeAQRkaIQELQFENEKVSLKLEEEIQENKDLikEN 150
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1424 EIEDLMVDVERSNAAAAALDKKQRNFDKilAEWKQKYEESQSELESSQKEARSLSTEL--------FKLKNAYEEsLEHL 1495
Cdd:pfam05483  151 NATRHLCNLLKETCARSAEKTKKYEYER--EETRQVYMDLNNNIEKMILAFEELRVQAenarlemhFKLKEDHEK-IQHL 227
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1496 ET-FKRENKNLQEEIS--------------DLTEQLGSSGKTIHELEKVRK-------QLEAEKMELQSALEEAEASLEH 1553
Cdd:pfam05483  228 EEeYKKEINDKEKQVSllliqitekenkmkDLTFLLEESRDKANQLEEKTKlqdenlkELIEKKDHLTKELEDIKMSLQR 307
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1554 EEGKILRAQLEFNQIKAEIERKLAEKDEEMEQ---AKRNHLRVVdslqTSLDAETRSRNEALRV-KKKMEGDLNEMEIql 1629
Cdd:pfam05483  308 SMSTQKALEEDLQIATKTICQLTEEKEAQMEElnkAKAAHSFVV----TEFEATTCSLEELLRTeQQRLEKNEDQLKI-- 381
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1630 shanrMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERrNNLLQAELEELRAVVEQTERSRKLAEQELIET 1709
Cdd:pfam05483  382 -----ITMELQKKSSELEEMTKFKNNKEVELEELKKILAEDEKLLDE-KKQFEKIAEELKGKEQELIFLLQAREKEIHDL 455
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1710 SERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMeqt 1789
Cdd:pfam05483  456 EIQLTAIKTSEEHYLKEVEDLKTELEKEKLKNIELTAHCDKLLLENKELTQEASDMTLELKKHQEDIINCKKQEERM--- 532
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1790 ikdlqhrldeaeqialkggKKQLQKLEARVRELENELEA---EQKRNAESVK-GMRKSERRIKELTYQTEEDRKNLLRLQ 1865
Cdd:pfam05483  533 -------------------LKQIENLEEKEMNLRDELESvreEFIQKGDEVKcKLDKSEENARSIEYEVLKKEKQMKILE 593
                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 124302198  1866 DL--------------VDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEER 1909
Cdd:pfam05483  594 NKcnnlkkqienknknIEELHQENKALKKKGSAENKQLNAYEIKVNKLELELASAKQK 651
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1011-1193 9.61e-06

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 50.79  E-value: 9.61e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1011 QAEEDKVNTLTKAKVKLEQQVDDLEGSLEQ-EKKvrmdLERAKRK-----LEGDLKLTQESIMDLENDKQQLDERLKKKD 1084
Cdd:COG3206   164 QNLELRREEARKALEFLEEQLPELRKELEEaEAA----LEEFRQKnglvdLSEEAKLLLQQLSELESQLAEARAELAEAE 239
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1085 FELNALNARIED---------EQALGSQLQKKLKELQARIEELEEELEAE----RTARAKVEKLRSDLSRELEEISERLE 1151
Cdd:COG3206   240 ARLAALRAQLGSgpdalpellQSPVIQQLRAQLAELEAELAELSARYTPNhpdvIALRAQIAALRAQLQQEAQRILASLE 319
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 124302198 1152 eaggatsVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALR 1193
Cdd:COG3206   320 -------AELEALQAREASLQAQLAQLEARLAELPELEAELR 354
Filament pfam00038
Intermediate filament protein;
1310-1578 1.13e-05

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 49.53  E-value: 1.13e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1310 QQLEDLKRQLEEEVKAKNALAHALQSARHDC-----DLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTE 1384
Cdd:pfam00038   21 RFLEQQNKLLETKISELRQKKGAEPSRLYSLyekeiEDLRRQLDTLTVERARLQLELDNLRLAAEDFRQKYEDELNLRTS 100
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1385 eLEEAKKKLAQRLQEAEEAVEAVNAKCSSLE------KTKHR-----LQNEIEDLMVDVERSNAaaaaldkKQRNFDKIL 1453
Cdd:pfam00038  101 -AENDLVGLRKDLDEATLARVDLEAKIESLKeelaflKKNHEeevreLQAQVSDTQVNVEMDAA-------RKLDLTSAL 172
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1454 AEWKQKYEEsqselessqkearslstelfkLKNAYEESLEhlETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQL 1533
Cdd:pfam00038  173 AEIRAQYEE---------------------IAAKNREEAE--EWYQSKLEELQQAAARNGDALRSAKEEITELRRTIQSL 229
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 124302198  1534 EAE-------KMELQSALEEAEASLEHE----EGKILRAQLEFNQIKAEIERKLAE 1578
Cdd:pfam00038  230 EIElqslkkqKASLERQLAETEERYELQladyQELISELEAELQETRQEMARQLRE 285
mukB PRK04863
chromosome partition protein MukB;
1175-1928 1.16e-05

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 50.73  E-value: 1.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1175 RRDLEEATLQHEATAAALRK------KHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVtSNMEQIIKAKANLEKM 1248
Cdd:PRK04863  282 RVHLEEALELRRELYTSRRQlaaeqyRLVEMARELAELNEAESDLEQDYQAASDHLNLVQTAL-RQQEKIERYQADLEEL 360
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1249 CRTLEDQM----------NEHRSKAEETQRSVNDLTSQRAklqtengelsrqlDEKEALISQLTRGkLTYTQQLedlkrQ 1318
Cdd:PRK04863  361 EERLEEQNevveeadeqqEENEARAEAAEEEVDELKSQLA-------------DYQQALDVQQTRA-IQYQQAV-----Q 421
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1319 LEEEVKAKNALAH-ALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYE-----TDAIQRTEELEEAKKK 1392
Cdd:PRK04863  422 ALERAKQLCGLPDlTADNAEDWLEEFQAKEQEATEELLSLEQKLSVAQAAHSQFEQAYQlvrkiAGEVSRSEAWDVAREL 501
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1393 LAQ--RLQEAEEAVEAVNAKCSSLEKtkhRLQNeiedlmvdversnaaaaaldkkQRNFDKILAEWKQKYEESQSELEss 1470
Cdd:PRK04863  502 LRRlrEQRHLAEQLQQLRMRLSELEQ---RLRQ----------------------QQRAERLLAEFCKRLGKNLDDED-- 554
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1471 qkearslstELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSgktIHELEkvrkQLEAEKMELQSALEE-AEA 1549
Cdd:PRK04863  555 ---------ELEQLQEELEARLESLSESVSEARERRMALRQQLEQLQAR---IQRLA----ARAPAWLAAQDALARlREQ 618
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1550 SLEHEEGkilRAQL-EFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAE-TRSRNEALRVKKKMEGDLNEmEI 1627
Cdd:PRK04863  619 SGEEFED---SQDVtEYMQQLLERERELTVERDELAARKQALDEEIERLSQPGGSEdPRLNALAERFGGVLLSEIYD-DV 694
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1628 QLSHANRMAA---------------EAQKQVKSLQSLLKDTQI------QLDDAVRANDDLKENIAIV------------ 1674
Cdd:PRK04863  695 SLEDAPYFSAlygparhaivvpdlsDAAEQLAGLEDCPEDLYLiegdpdSFDDSVFSVEELEKAVVVKiadrqwrysrfp 774
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1675 ----------ERRNNLLQAELEELravveqTERSRKLAEQelietSERVQLLHSQNTSLINQK-------------KKMD 1731
Cdd:PRK04863  775 evplfgraarEKRIEQLRAEREEL------AERYATLSFD-----VQKLQRLHQAFSRFIGSHlavafeadpeaelRQLN 843
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1732 ADLSQLQTEV---EEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSaHLERmkknmeqtIKDLQHRLDEAEQ----IA 1804
Cdd:PRK04863  844 RRRVELERALadhESQEQQQRSQLEQAKEGLSALNRLLPRLNLLADET-LADR--------VEEIREQLDEAEEakrfVQ 914
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1805 LKGGK-KQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTE-------EDRKNLL-RLQDLVDKLQLKV 1875
Cdd:PRK04863  915 QHGNAlAQLEPIVSVLQSDPEQFEQLKQDYQQAQQTQRDAKQQAFALTEVVQrrahfsyEDAAEMLaKNSDLNEKLRQRL 994
                         810       820       830       840       850
                  ....*....|....*....|....*....|....*....|....*....|...
gi 124302198 1876 KAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIG 1928
Cdd:PRK04863  995 EQAEQERTRAREQLRQAQAQLAQYNQVLASLKSSYDAKRQMLQELKQELQDLG 1047
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
869-1792 1.28e-05

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 50.82  E-value: 1.28e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   869 RRKELEEKMVSLLQEKNDlqlQVQAEQDNLADAEERCDQLIKNKIqlEAKVKEMNERLEDEEEMNAELTAKKRKLEDECS 948
Cdd:TIGR01612  501 RMKDFKDIIDFMELYKPD---EVPSKNIIGFDIDQNIKAKLYKEI--EAGLKESYELAKNWKKLIHEIKKELEEENEDSI 575
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   949 ELKRDIDDLELTLAKVEKE-------KHATENKVKNLTEEmaglDEIIAKLTKEKKALqEAHQQALDDL-QAEEDKVNTL 1020
Cdd:TIGR01612  576 HLEKEIKDLFDKYLEIDDEiiyinklKLELKEKIKNISDK----NEYIKKAIDLKKII-ENNNAYIDELaKISPYQVPEH 650
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1021 TKAKVKLEQQVDDlegslEQEKKVRMDLERAKRKLEgdlKLTQESIMDLENDKQQLDERLKKKDFELNAL-NARIEDEQA 1099
Cdd:TIGR01612  651 LKNKDKIYSTIKS-----ELSKIYEDDIDALYNELS---SIVKENAIDNTEDKAKLDDLKSKIDKEYDKIqNMETATVEL 722
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1100 LGSQLQKKLKELQARIEELEeeleaertarakvEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLE 1179
Cdd:TIGR01612  723 HLSNIENKKNELLDIIVEIK-------------KHIHGEINKDLNKILEDFKNKEKELSNKINDYAKEKDELNKYKSKIS 789
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1180 EATLQHEATAAALRKKHADS---VAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIkakaNLEKMCRtlEDQM 1256
Cdd:TIGR01612  790 EIKNHYNDQINIDNIKDEDAkqnYDKSKEYIKTISIKEDEIFKIINEMKFMKDDFLNKVDKFI----NFENNCK--EKID 863
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1257 NEHRSKAEETQRSVNDLTSQRAKLQTENgelsrqLDEKEALISQLTRGKLTYTQQLEDLKRqLEEEVKAKNALAHALQSA 1336
Cdd:TIGR01612  864 SEHEQFAELTNKIKAEISDDKLNDYEKK------FNDSKSLINEINKSIEEEYQNINTLKK-VDEYIKICENTKESIEKF 936
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1337 RHDCDLLREQYEEETEakaelqrVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAE--EAVEAVNAKCSSL 1414
Cdd:TIGR01612  937 HNKQNILKEILNKNID-------TIKESNLIEKSYKDKFDNTLIDKINELDKAFKDASLNDYEAKnnELIKYFNDLKANL 1009
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1415 EKTKHRLQ----NEIEDLMVDVERSNAAAaaldkkQRNFDKI-LAEWKQKYEESQSELESSQKEARSLSTELFKLK---- 1485
Cdd:TIGR01612 1010 GKNKENMLyhqfDEKEKATNDIEQKIEDA------NKNIPNIeIAIHTSIYNIIDEIEKEIGKNIELLNKEILEEAeini 1083
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1486 ---NAYEESLEHL---ETFKRENKNLQEEISDLTEQLGSSG----KTIHELEKVRKQLEAEKMELQSAL----------- 1544
Cdd:TIGR01612 1084 tnfNEIKEKLKHYnfdDFGKEENIKYADEINKIKDDIKNLDqkidHHIKALEEIKKKSENYIDEIKAQIndledvadkai 1163
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1545 -----EEAEASLEHEEGKILRAQLEFNQIKAEI-ERKLAEKDE-EMEQAKRNHLRVVDSLQT----SLDAEtrsrnealr 1613
Cdd:TIGR01612 1164 snddpEEIEKKIENIVTKIDKKKNIYDEIKKLLnEIAEIEKDKtSLEEVKGINLSYGKNLGKlfleKIDEE--------- 1234
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1614 vKKKMEGDLNEMEIQLSHANRMAAEAQkQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVE 1693
Cdd:TIGR01612 1235 -KKKSEHMIKAMEAYIEDLDEIKEKSP-EIENEMGIEMDIKAEMETFNISHDDDKDHHIISKKHDENISDIREKSLKIIE 1312
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1694 QTERSRKLAEqelIETSERVQLLHSQ-NTSLINQKKKMDADLSQLQT-----EVEEAVQECRNAEEKAKKAITDAAMMAE 1767
Cdd:TIGR01612 1313 DFSEESDIND---IKKELQKNLLDAQkHNSDINLYLNEIANIYNILKlnkikKIIDEVKEYTKEIEENNKNIKDELDKSE 1389
                          970       980
                   ....*....|....*....|....*
gi 124302198  1768 ELKKEQDTSAHLERMKKNMEQTIKD 1792
Cdd:TIGR01612 1390 KLIKKIKDDINLEECKSKIESTLDD 1414
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
1310-1906 1.33e-05

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 50.34  E-value: 1.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1310 QQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLR---------EQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAI 1380
Cdd:COG3096   306 YRLVEMARELEELSARESDLEQDYQAASDHLNLVQtalrqqekiERYQEDLEELTERLEEQEEVVEEAAEQLAEAEARLE 385
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1381 QRTEELEEAKKKLA--------------------QRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDL---MVDVER--- 1434
Cdd:COG3096   386 AAEEEVDSLKSQLAdyqqaldvqqtraiqyqqavQALEKARALCGLPDLTPENAEDYLAAFRAKEQQAteeVLELEQkls 465
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1435 -SNAAAAALDKKQRNFDKILAE------WKQkyeesqseLESSQKEARSLSTELFKLkNAYEESLEHLETFKRENKNLQE 1507
Cdd:COG3096   466 vADAARRQFEKAYELVCKIAGEversqaWQT--------ARELLRRYRSQQALAQRL-QQLRAQLAELEQRLRQQQNAER 536
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1508 EISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEA---SLEHEEGKiLRAQLEFNQIKAEIERKLAEK----D 1580
Cdd:COG3096   537 LLEEFCQRIGQQLDAAEELEELLAELEAQLEELEEQAAEAVEqrsELRQQLEQ-LRARIKELAARAPAWLAAQDAlerlR 615
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1581 EEMEQAKRNHLRVVDSLQTSLDAE---TRSRNEALRVKKKMEGDLNEmeiqLSHAN-----RMAAEAQKQVKSLQSLLKD 1652
Cdd:COG3096   616 EQSGEALADSQEVTAAMQQLLEREreaTVERDELAARKQALESQIER----LSQPGgaedpRLLALAERLGGVLLSEIYD 691
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1653 tQIQLDDA-------------------------VRANDDLKENIAIVERR-----NNLLQAELEELRAVVEQTERS---- 1698
Cdd:COG3096   692 -DVTLEDApyfsalygparhaivvpdlsavkeqLAGLEDCPEDLYLIEGDpdsfdDSVFDAEELEDAVVVKLSDRQwrys 770
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1699 ---------RKLAEQELIETSE-----------------RVQLLHSQNTSLINQKKKM--DAD-------LSQLQTEVEE 1743
Cdd:COG3096   771 rfpevplfgRAAREKRLEELRAerdelaeqyakasfdvqKLQRLHQAFSQFVGGHLAVafAPDpeaelaaLRQRRSELER 850
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1744 AVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLErmKKNMEQTIKDLQHRLDEAEQ----IALKGgkKQLQKLEARV 1819
Cdd:COG3096   851 ELAQHRAQEQQLRQQLDQLKEQLQLLNKLLPQANLLA--DETLADRLEELREELDAAQEaqafIQQHG--KALAQLEPLV 926
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1820 RELEN-------------ELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRknLLRLQDLVDKLQLKVkaykRQAEEAE 1886
Cdd:COG3096   927 AVLQSdpeqfeqlqadylQAKEQQRRLKQQIFALSEVVQRRPHFSYEDAVGL--LGENSDLNEKLRARL----EQAEEAR 1000
                         730       740
                  ....*....|....*....|
gi 124302198 1887 EQANTNLskfRKVQHELDEA 1906
Cdd:COG3096  1001 REAREQL---RQAQAQYSQY 1017
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1090-1364 1.46e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 50.02  E-value: 1.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1090 LNARIEDEQALGSQLQKKLKELQARIeeleeeleaeRTARAKVEKLRS-----DLSRELEEISERLEEAggatsvqiemn 1164
Cdd:COG3206   166 LELRREEARKALEFLEEQLPELRKEL----------EEAEAALEEFRQknglvDLSEEAKLLLQQLSEL----------- 224
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1165 kkrEAEFQKMRRDLEEAtlqhEATAAALRKKHADSVAELGEQIDN--LQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAK 1242
Cdd:COG3206   225 ---ESQLAEARAELAEA----EARLAALRAQLGSGPDALPELLQSpvIQQLRAQLAELEAELAELSARYTPNHPDVIALR 297
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1243 ANLEkmcrTLEDQMnehrskAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRgkltYTQQLEDLKRQLEee 1322
Cdd:COG3206   298 AQIA----ALRAQL------QQEAQRILASLEAELEALQAREASLQAQLAQLEARLAELPE----LEAELRRLEREVE-- 361
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 124302198 1323 vkaknalahalqsarhdcdLLREQYE------EETEAKAELQ----RVLSKA 1364
Cdd:COG3206   362 -------------------VARELYEsllqrlEEARLAEALTvgnvRVIDPA 394
MutS2 COG1193
dsDNA-specific endonuclease/ATPase MutS2 [Replication, recombination and repair];
1048-1202 1.46e-05

dsDNA-specific endonuclease/ATPase MutS2 [Replication, recombination and repair];


Pssm-ID: 440806 [Multi-domain]  Cd Length: 784  Bit Score: 50.14  E-value: 1.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1048 LERAKRKLEGDLKLTQESIMDLENDKQQLDERLKkkdfELNALNARIEDEQAlgsQLQKKLKELQARieeleeELEAERT 1127
Cdd:COG1193   502 IERARELLGEESIDVEKLIEELERERRELEEERE----EAERLREELEKLRE---ELEEKLEELEEE------KEEILEK 568
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 124302198 1128 ARAKVEKLRSDLSRELEEISERLEEAggatsvqiemnKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAE 1202
Cdd:COG1193   569 AREEAEEILREARKEAEELIRELREA-----------QAEEEELKEARKKLEELKQELEEKLEKPKKKAKPAKPP 632
PRK04778 PRK04778
septation ring formation regulator EzrA; Provisional
1485-1920 1.52e-05

septation ring formation regulator EzrA; Provisional


Pssm-ID: 179877 [Multi-domain]  Cd Length: 569  Bit Score: 49.83  E-value: 1.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1485 KNAYEEsLEHLETFKRE--NKNLQEEISDLtEQLGSSGKTIHELEKVRKQ----------------LEAEK-------ME 1539
Cdd:PRK04778   25 KRNYKR-IDELEERKQEleNLPVNDELEKV-KKLNLTGQSEEKFEEWRQKwdeivtnslpdieeqlFEAEElndkfrfRK 102
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1540 LQSALEEAEASLEHEEGKILRAQLEFNQIKaEIERKLaekDEEMEQAKRNHlrvvDSLQTSLDAETRSRNEALrvkKKME 1619
Cdd:PRK04778  103 AKHEINEIESLLDLIEEDIEQILEELQELL-ESEEKN---REEVEQLKDLY----RELRKSLLANRFSFGPAL---DELE 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1620 GDLNEMEIQLSHANRMAA-----EAQKQVKSLQSLLKDTQIQLDDavranddlkenI-AIVERRNNLLQAELEELRAVVE 1693
Cdd:PRK04778  172 KQLENLEEEFSQFVELTEsgdyvEAREILDQLEEELAALEQIMEE-----------IpELLKELQTELPDQLQELKAGYR 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1694 Q-TERSRKLAEQELIETSERVQLLHSQNTSLINQ-------------KKKMDADLSQLQTEVEeavqeCRNAEEKAKKAI 1759
Cdd:PRK04778  241 ElVEEGYHLDHLDIEKEIQDLKEQIDENLALLEEldldeaeekneeiQERIDQLYDILEREVK-----ARKYVEKNSDTL 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1760 TDAAMMAEELKKEqdTSAHLERMKKN-------------MEQTIKDLQHRLDEAEQiALKGGKKQLQKLEARVRELENEL 1826
Cdd:PRK04778  316 PDFLEHAKEQNKE--LKEEIDRVKQSytlneselesvrqLEKQLESLEKQYDEITE-RIAEQEIAYSELQEELEEILKQL 392
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1827 ---EAEQKRNAESVKGMRKSERRIKEltyQTEEDRKNLLRLQDLVDKLQL-----KVKAYKRQAEEAEEQANTNLSKFR- 1897
Cdd:PRK04778  393 eeiEKEQEKLSEMLQGLRKDELEARE---KLERYRNKLHEIKRYLEKSNLpglpeDYLEMFFEVSDEIEALAEELEEKPi 469
                         490       500
                  ....*....|....*....|....*.
gi 124302198 1898 ---KVQHELDEAEERADIAESQVNKL 1920
Cdd:PRK04778  470 nmeAVNRLLEEATEDVETLEEETEEL 495
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1744-1927 1.53e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 49.38  E-value: 1.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1744 AVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQiALKGGKKQLQKLEARVRELE 1823
Cdd:COG4942    18 QADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQ-ELAALEAELAELEKEIAELR 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1824 NELEAEQKRNAESVKGMRKSERR---------------IKELTY----------QTEEDRKNLLRLQDLVDKLQLKVKAY 1878
Cdd:COG4942    97 AELEAQKEELAELLRALYRLGRQpplalllspedfldaVRRLQYlkylaparreQAEELRADLAELAALRAELEAERAEL 176
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 124302198 1879 KRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDI 1927
Cdd:COG4942   177 EALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEEL 225
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1381-1611 1.67e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 49.38  E-value: 1.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1381 QRTEELEEAKKKLAQ---RLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWK 1457
Cdd:COG4942    24 EAEAELEQLQQEIAElekELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQK 103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1458 QKYeesQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLgssgktiHELEKVRKQLEAEK 1537
Cdd:COG4942   104 EEL---AELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADL-------AELAALRAELEAER 173
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 124302198 1538 MELQSALEEAEAslehEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQtSLDAETRSRNEA 1611
Cdd:COG4942   174 AELEALLAELEE----ERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIA-RLEAEAAAAAER 242
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1432-1834 2.01e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 49.77  E-value: 2.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1432 VERSNAAAAALDKKQRNFDKILAEwKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEhLETFKRENKNLQEEISD 1511
Cdd:COG4717    73 LKELEEELKEAEEKEEEYAELQEE-LEELEEELEELEAELEELREELEKLEKLLQLLPLYQE-LEALEAELAELPERLEE 150
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1512 LTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHL 1591
Cdd:COG4717   151 LEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELE 230
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1592 RVVDSLQTSLDAETRSRNEAL------------RVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDD 1659
Cdd:COG4717   231 QLENELEAAALEERLKEARLLlliaaallallgLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQAL 310
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1660 AVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQ--ELIETSERVQLLHSQNTSLINQKKKMDADLSQL 1737
Cdd:COG4717   311 PALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREaeELEEELQLEELEQEIAALLAEAGVEDEEELRAA 390
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1738 QTEVEEAVQ---ECRNAEEKAKKAITDAAMMAEELKKEQ--DTSAHLERMKKNMEQTIKDLQHRLDEAE-QIALKGGKKQ 1811
Cdd:COG4717   391 LEQAEEYQElkeELEELEEQLEELLGELEELLEALDEEEleEELEELEEELEELEEELEELREELAELEaELEQLEEDGE 470
                         410       420
                  ....*....|....*....|...
gi 124302198 1812 LQKLEARVRELENELEAEQKRNA 1834
Cdd:COG4717   471 LAELLQELEELKAELRELAEEWA 493
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
1686-1935 2.41e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 49.55  E-value: 2.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1686 EELRAVVEQT-------ERsRKLAEQELIETSE---RVQLLHSQntslinqkkkMDADLSQLQTEVEEAVqecRNAEEKA 1755
Cdd:COG1196   155 EERRAIIEEAagiskykER-KEEAERKLEATEEnleRLEDILGE----------LERQLEPLERQAEKAE---RYRELKE 220
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1756 KKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQiALKGGKKQLQKLEARVRELENELEAEQKRNAE 1835
Cdd:COG1196   221 ELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEA-ELEELRLELEELELELEEAQAEEYELLAELAR 299
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1836 SVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAES 1915
Cdd:COG1196   300 LEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEE 379
                         250       260
                  ....*....|....*....|
gi 124302198 1916 QVNKLRAKSRDIGTKGLNEE 1935
Cdd:COG1196   380 ELEELAEELLEALRAAAELA 399
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
1472-1930 2.43e-05

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 49.33  E-value: 2.43e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1472 KEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASL 1551
Cdd:pfam05483  120 KAIQELQFENEKVSLKLEEEIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMILAF 199
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1552 EHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSH 1631
Cdd:pfam05483  200 EELRVQAENARLEMHFKLKEDHEKIQHLEEEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKANQLEEKTKL 279
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1632 ANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSE 1711
Cdd:pfam05483  280 QDENLKELIEKKDHLTKELEDIKMSLQRSMSTQKALEEDLQIATKTICQLTEEKEAQMEELNKAKAAHSFVVTEFEATTC 359
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1712 RVQ-LLHSQNTSLIN---QKKKMDADLSQLQTEVEEAVQECRNAE---EKAKKAITDAAMMAEELKKEQDTSahlERMKK 1784
Cdd:pfam05483  360 SLEeLLRTEQQRLEKnedQLKIITMELQKKSSELEEMTKFKNNKEvelEELKKILAEDEKLLDEKKQFEKIA---EELKG 436
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1785 NMEQTIKDLQHRLDEAE--QIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLL 1862
Cdd:pfam05483  437 KEQELIFLLQAREKEIHdlEIQLTAIKTSEEHYLKEVEDLKTELEKEKLKNIELTAHCDKLLLENKELTQEASDMTLELK 516
                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 124302198  1863 RLQDLVDKLQLKVKAYKRQAE---EAEEQANTNLSKFRK--------VQHELDEAEERADIAESQVNKLRAKSRDIGTK 1930
Cdd:pfam05483  517 KHQEDIINCKKQEERMLKQIEnleEKEMNLRDELESVREefiqkgdeVKCKLDKSEENARSIEYEVLKKEKQMKILENK 595
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
843-1014 2.51e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 48.67  E-value: 2.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  843 AEREKEMASMKEEFTRLKEALEKseaRRKELEEKMVSLLQEKNDLQ-LQVQAEQDNLADAEERCDQLikNKIqleakVKE 921
Cdd:COG3883    61 EALQAEIDKLQAEIAEAEAEIEE---RREELGERARALYRSGGSVSyLDVLLGSESFSDFLDRLSAL--SKI-----ADA 130
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  922 MNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQE 1001
Cdd:COG3883   131 DADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEA 210
                         170
                  ....*....|...
gi 124302198 1002 AHQQALDDLQAEE 1014
Cdd:COG3883   211 AAAAAAAAAAAAA 223
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
860-1681 2.87e-05

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 49.66  E-value: 2.87e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   860 KEALEK--SEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLA------------DAEERCDQLIKN----KIQLEAKVKE 921
Cdd:TIGR01612  976 INELDKafKDASLNDYEAKNNELIKYFNDLKANLGKNKENMLyhqfdekekatnDIEQKIEDANKNipniEIAIHTSIYN 1055
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   922 MNERLEDEEEMNAELTAKK--RKLEDECSELKRDIDDLEL----TLAKVEKEKHATE-NKVKNlteEMAGLDEIIAKLTK 994
Cdd:TIGR01612 1056 IIDEIEKEIGKNIELLNKEilEEAEINITNFNEIKEKLKHynfdDFGKEENIKYADEiNKIKD---DIKNLDQKIDHHIK 1132
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   995 EKKALQEAHQQALDDLQAEEDKVNTLTKAKVkleqQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQEsIMDLENDK- 1073
Cdd:TIGR01612 1133 ALEEIKKKSENYIDEIKAQINDLEDVADKAI----SNDDPEEIEKKIENIVTKIDKKKNIYDEIKKLLNE-IAEIEKDKt 1207
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1074 ---------------------QQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAeRTARAKV 1132
Cdd:TIGR01612 1208 sleevkginlsygknlgklflEKIDEEKKKSEHMIKAMEAYIEDLDEIKEKSPEIENEMGIEMDIKAEMETF-NISHDDD 1286
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1133 EKLRSDLSRELEEISERLEEaggatSVQIEMNKKREAEFQKMRRDLEEATLQHEataaalrkKHADSVAELGEQIDNLQR 1212
Cdd:TIGR01612 1287 KDHHIISKKHDENISDIREK-----SLKIIEDFSEESDINDIKKELQKNLLDAQ--------KHNSDINLYLNEIANIYN 1353
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1213 VKQ--KLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMN--EHRSKAEETQ---------RSVNDLTSQRAK 1279
Cdd:TIGR01612 1354 ILKlnKIKKIIDEVKEYTKEIEENNKNIKDELDKSEKLIKKIKDDINleECKSKIESTLddkdideciKKIKELKNHILS 1433
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1280 LQTENGELSRQLDEKEALISQLTRgkltyTQQLEDLKRQLEEEVKAKNAlahalqSARHDCDL--LREQYEEETEAKAEL 1357
Cdd:TIGR01612 1434 EESNIDTYFKNADENNENVLLLFK-----NIEMADNKSQHILKIKKDNA------TNDHDFNIneLKEHIDKSKGCKDEA 1502
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1358 QR----------VLSKANSEVAQWRTKYETDAIQrtEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNE--- 1424
Cdd:TIGR01612 1503 DKnakaieknkeLFEQYKKDVTELLNKYSALAIK--NKFAKTKKDSEIIIKEIKDAHKKFILEAEKSEQKIKEIKKEkfr 1580
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1425 IEDLMVDVERSNAAAAALDKKQRNFDkilaewkqkyeesqselessqkearslsTELFKLKNAYEESLEHLetfkRENKN 1504
Cdd:TIGR01612 1581 IEDDAAKNDKSNKAAIDIQLSLENFE----------------------------NKFLKISDIKKKINDCL----KETES 1628
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1505 LQEEISDLT-----EQLGSSGKTIHELEKVRKQLEAEKMELqsalEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEK 1579
Cdd:TIGR01612 1629 IEKKISSFSidsqdTELKENGDNLNSLQEFLESLKDQKKNI----EDKKKELDELDSEIEKIEIDVDQHKKNYEIGIIEK 1704
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1580 DEEMEQAKRNHL------------RVVDSLQTSlDAETRSRNEALRVKKKMEGDLNEMEIQLSH--ANRMAAEAQKQVKS 1645
Cdd:TIGR01612 1705 IKEIAIANKEEIesikelieptieNLISSFNTN-DLEGIDPNEKLEEYNTEIGDIYEEFIELYNiiAGCLETVSKEPITY 1783
                          890       900       910
                   ....*....|....*....|....*....|....*.
gi 124302198  1646 LQslLKDTQIQlddavrANDDLKENIAIVERRNNLL 1681
Cdd:TIGR01612 1784 DE--IKNTRIN------AQNEFLKIIEIEKKSKSYL 1811
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
1340-1552 2.94e-05

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 49.16  E-value: 2.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1340 CDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKH 1419
Cdd:PRK05771   38 EELSNERLRKLRSLLTKLSEALDKLRSYLPKLNPLREEKKKVSVKSLEELIKDVEEELEKIEKEIKELEEEISELENEIK 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1420 RLQNEIEDLM------VDVER----SNAAAAALDKKQRNFDKILAEWKQKYEESQSELESS-------QKEARSLSTELF 1482
Cdd:PRK05771  118 ELEQEIERLEpwgnfdLDLSLllgfKYVSVFVGTVPEDKLEELKLESDVENVEYISTDKGYvyvvvvvLKELSDEVEEEL 197
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 124302198 1483 KlKNAYEE-SLEHLETFKRENKNLQEEISDLTEQLGSsgkTIHELEKVRKQLEAEKM----ELQSALEEAEASLE 1552
Cdd:PRK05771  198 K-KLGFERlELEEEGTPSELIREIKEELEEIEKERES---LLEELKELAKKYLEELLalyeYLEIELERAEALSK 268
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
955-1339 3.37e-05

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 49.07  E-value: 3.37e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   955 DDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDL-------QAEEDKVN-TLTKAKVK 1026
Cdd:pfam12128  600 EELRERLDKAEEALQSAREKQAAAEEQLVQANGELEKASREETFARTALKNARLDLrrlfdekQSEKDKKNkALAERKDS 679
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1027 LEQQVDDLEGSLEQ-EKKVRMDLERAKRKLEGDLKLTQESIMDLENDkqqlderlkkKDFELNALNARIEDEQALGSQLQ 1105
Cdd:pfam12128  680 ANERLNSLEAQLKQlDKKHQAWLEEQKEQKREARTEKQAYWQVVEGA----------LDAQLALLKAAIAARRSGAKAEL 749
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1106 KKLKELQARieeleeeleaERTARAKVEKLRSDLSRELEEISERLEEAggatsvqiemnKKREAEFQKMRRDLEEATLQH 1185
Cdd:pfam12128  750 KALETWYKR----------DLASLGVDPDVIAKLKREIRTLERKIERI-----------AVRRQEVLRYFDWYQETWLQR 808
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1186 EataaalrkkhadsvaelgeqiDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEE 1265
Cdd:pfam12128  809 R---------------------PRLATQLSNIERAISELQQQLARLIADTKLRRAKLEMERKASEKQQVRLSENLRGLRC 867
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 124302198  1266 TQRSVNDLTSQRAKLQTEnGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEevKAKNALAHALQSARHD 1339
Cdd:pfam12128  868 EMSKLATLKEDANSEQAQ-GSIGERLAQLEDLKLKRDYLSESVKKYVEHFKNVIAD--HSGSGLAETWESLREE 938
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
1535-1920 4.40e-05

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 48.80  E-value: 4.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1535 AEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERK-LAEKDEEME-QAKRNHLRVVdslqtsldaetrsrNEAL 1612
Cdd:COG3096   278 NERRELSERALELRRELFGARRQLAEEQYRLVEMARELEELsARESDLEQDyQAASDHLNLV--------------QTAL 343
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1613 RVKKKME---GDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRN----NLLQAeL 1685
Cdd:COG3096   344 RQQEKIEryqEDLEELTERLEEQEEVVEEAAEQLAEAEARLEAAEEEVDSLKSQLADYQQALDVQQTRAiqyqQAVQA-L 422
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1686 EELRAVVEQTERSRKLAEQELIETSERVQLLHSqntSLINQKKKM-DADLSQLQTE-VEEAVQ------ECRNAEEKAKK 1757
Cdd:COG3096   423 EKARALCGLPDLTPENAEDYLAAFRAKEQQATE---EVLELEQKLsVADAARRQFEkAYELVCkiagevERSQAWQTARE 499
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1758 AITDAAMMAEELKKEQDTSAHLERMKKNMEQtikdlQHRLDE-AEQIALKGGKK--QLQKLEARVRELENELEAEQKRNA 1834
Cdd:COG3096   500 LLRRYRSQQALAQRLQQLRAQLAELEQRLRQ-----QQNAERlLEEFCQRIGQQldAAEELEELLAELEAQLEELEEQAA 574
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1835 ESVKGMRKSERRIKELTYQTEEDRK---NLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERAD 1911
Cdd:COG3096   575 EAVEQRSELRQQLEQLRARIKELAArapAWLAAQDALERLREQSGEALADSQEVTAAMQQLLEREREATVERDELAARKQ 654

                  ....*....
gi 124302198 1912 IAESQVNKL 1920
Cdd:COG3096   655 ALESQIERL 663
46 PHA02562
endonuclease subunit; Provisional
931-1221 5.00e-05

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 48.09  E-value: 5.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  931 EMNAELTAKKRkledecsELKRDIDDLELTLAKVEkEKHATENKVKNLTEEMAG--LDEIIAKLTKEKKALQEAHQQald 1008
Cdd:PHA02562  167 EMDKLNKDKIR-------ELNQQIQTLDMKIDHIQ-QQIKTYNKNIEEQRKKNGenIARKQNKYDELVEEAKTIKAE--- 235
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1009 dlqaeedkVNTLTKAKVKLEQQVDDLEGSLeqeKKVRMDLERAKRKLEgdlKLTQESIMDLEND-----KQQLDERlkkk 1083
Cdd:PHA02562  236 --------IEELTDELLNLVMDIEDPSAAL---NKLNTAAAKIKSKIE---QFQKVIKMYEKGGvcptcTQQISEG---- 297
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1084 dfelnalNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAggatsvqiem 1163
Cdd:PHA02562  298 -------PDRITKIKDKLKELQHSLEKLDTAIDELEEIMDEFNEQSKKLLELKNKISTNKQSLITLVDKA---------- 360
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 124302198 1164 nKKREAEFQKmrrdleeatlqheatAAALRKKHADSVAELGEQIDNLQRVKQKLEKEK 1221
Cdd:PHA02562  361 -KKVKAAIEE---------------LQAEFVDNAEELAKLQDELDKIVKTKSELVKEK 402
PRK01156 PRK01156
chromosome segregation protein; Provisional
1312-1887 5.23e-05

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 48.36  E-value: 5.23e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1312 LEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYE--TDAIQRTEELEEA 1389
Cdd:PRK01156  171 LKDVIDMLRAEISNIDYLEEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDYNnlKSALNELSSLEDM 250
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1390 KKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLqNEIEDLMVDVERSNAAAAALDKKQ-RNFDKILAEWK---QKYeesqs 1465
Cdd:PRK01156  251 KNRYESEIKTAESDLSMELEKNNYYKELEERH-MKIINDPVYKNRNYINDYFKYKNDiENKKQILSNIDaeiNKY----- 324
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1466 elessqKEARSLSTELFKLKNAYEESlehletfKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALE 1545
Cdd:PRK01156  325 ------HAIIKKLSVLQKDYNDYIKK-------KSRYDDLNNQILELEGYEMDYNSYLKSIESLKKKIEEYSKNIERMSA 391
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1546 EAEASLEHEEGKilraQLEFNQIKAEIERKLAEKDEEmeqakrnhlrvVDSLQTSLDAETRSRNEALRVKKKMEG----- 1620
Cdd:PRK01156  392 FISEILKIQEID----PDAIKKELNEINVKLQDISSK-----------VSSLNQRIRALRENLDELSRNMEMLNGqsvcp 456
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1621 ----DLNEMEIqlshaNRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKEniaiveRRNNLLQAELEELRAVVEQTE 1696
Cdd:PRK01156  457 vcgtTLGEEKS-----NHIINHYNEKKSRLEEKIREIEIEVKDIDEKIVDLKK------RKEYLESEEINKSINEYNKIE 525
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1697 RSRklAEQELIETSE-RVQLLHSQNTSLINQKKKMD-ADLSQLQTEVEEA--------VQECRNAEEKAKKAITDAAMMA 1766
Cdd:PRK01156  526 SAR--ADLEDIKIKInELKDKHDKYEEIKNRYKSLKlEDLDSKRTSWLNAlavislidIETNRSRSNEIKKQLNDLESRL 603
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1767 EELKKE-QDTSAHLERMKKNMEQTIKDLQHRLDEAEqiALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSER 1845
Cdd:PRK01156  604 QEIEIGfPDDKSYIDKSIREIENEANNLNNKYNEIQ--ENKILIEKLRGKIDNYKKQIAEIDSIIPDLKEITSRINDIED 681
                         570       580       590       600
                  ....*....|....*....|....*....|....*....|..
gi 124302198 1846 RIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEE 1887
Cdd:PRK01156  682 NLKKSRKALDDAKANRARLESTIEILRTRINELSDRINDINE 723
WEMBL pfam05701
Weak chloroplast movement under blue light; WEMBL consists of several plant proteins required ...
1384-1919 5.78e-05

Weak chloroplast movement under blue light; WEMBL consists of several plant proteins required for the chloroplast avoidance response under high intensity blue light. This avoidance response consists in the relocation of chloroplasts on the anticlinal side of exposed cells. Acts in association with PMI2 to maintain the velocity of chloroplast photo-relocation movement via the regulation of cp-actin filaments. Thus several member-sequences are described as "myosin heavy chain-like".


Pssm-ID: 461718 [Multi-domain]  Cd Length: 562  Bit Score: 48.10  E-value: 5.78e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1384 EELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKhrlqNEIEDLMVDVERsnaaaAALDKKQRNFDKILAEWKQKyees 1463
Cdd:pfam05701   42 LELEKVQEEIPEYKKQSEAAEAAKAQVLEELESTK----RLIEELKLNLER-----AQTEEAQAKQDSELAKLRVE---- 108
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1464 QSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDL----------TEQLGSSGKtihELEKVRKQL 1533
Cdd:pfam05701  109 EMEQGIADEASVAAKAQLEVAKARHAAAVAELKSVKEELESLRKEYASLvserdiaikrAEEAVSASK---EIEKTVEEL 185
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1534 EAEKMELQSALEEAEAS-LEHEEGKIlRAQLEFNQIKAEIERKLAEKDEEMEQAkRNHLRVVDSLQTSLDAetrsrNEAL 1612
Cdd:pfam05701  186 TIELIATKESLESAHAAhLEAEEHRI-GAALAREQDKLNWEKELKQAEEELQRL-NQQLLSAKDLKSKLET-----ASAL 258
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1613 RVKKK------MEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDdavRANDDLKENIAIVERrnnlLQAELE 1686
Cdd:pfam05701  259 LLDLKaelaayMESKLKEEADGEGNEKKTSTSIQAALASAKKELEEVKANIE---KAKDEVNCLRVAAAS----LRSELE 331
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1687 ELRAVVEQTERSRKLAEqelietservqllhsqntslinqkkkmdADLSQLQTEVEEAVQECRNAEEKAKKAitdAAMMA 1766
Cdd:pfam05701  332 KEKAELASLRQREGMAS----------------------------IAVSSLEAELNRTKSEIALVQAKEKEA---REKMV 380
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1767 EELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQialkgGKKQLQKLEARVRELENELEA---EQKRNAESVKGMRKS 1843
Cdd:pfam05701  381 ELPKQLQQAAQEAEEAKSLAQAAREELRKAKEEAEQ-----AKAAASTVESRLEAVLKEIEAakaSEKLALAAIKALQES 455
                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 124302198  1844 ERRiKELTYQTEEDRKNLLRLQDLvdklqlkvKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNK 1919
Cdd:pfam05701  456 ESS-AESTNQEDSPRGVTLSLEEY--------YELSKRAHEAEELANKRVAEAVSQIEEAKESELRSLEKLEEVNR 522
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
1075-1555 5.81e-05

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 48.20  E-value: 5.81e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1075 QLDERLKKKdfELNALNARIEDEQALGSQLQ------KKLKELQARIeeleeeleaertarakveklrsdlsrelEEISE 1148
Cdd:pfam05557   13 QLQNEKKQM--ELEHKRARIELEKKASALKRqldresDRNQELQKRI----------------------------RLLEK 62
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1149 RLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQhEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEL 1228
Cdd:pfam05557   63 REAEAEEALREQAELNRLKKKYLEALNKKLNEKESQ-LADAREVISCLKNELSELRRQIQRAELELQSTNSELEELQERL 141
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1229 DDVTSNMEQIIKAKANLEKMCRTL---EDQMNE---HRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALiSQLT 1302
Cdd:pfam05557  142 DLLKAKASEAEQLRQNLEKQQSSLaeaEQRIKElefEIQSQEQDSEIVKNSKSELARIPELEKELERLREHNKHL-NENI 220
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1303 RGKLTYTQQLEDLKRQLeeevkaknalahalqsarhdcdllrEQYEEETEAKAELQRVLSKANSEVAQWRTKYETDA--I 1380
Cdd:pfam05557  221 ENKLLLKEEVEDLKRKL-------------------------EREEKYREEAATLELEKEKLEQELQSWVKLAQDTGlnL 275
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1381 QRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNE-------IEDLMVDVERSNAAAAALDK------KQR 1447
Cdd:pfam05557  276 RSPEDLSRRIEQLQQREIVLKEENSSLTSSARQLEKARRELEQElaqylkkIEDLNKKLKRHKALVRRLQRrvllltKER 355
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1448 NFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEES-------LEHLETFKRENKNLQEEISDLTEQ----- 1515
Cdd:pfam05557  356 DGYRAILESYDKELTMSNYSPQLLERIEEAEDMTQKMQAHNEEMeaqlsvaEEELGGYKQQAQTLERELQALRQQeslad 435
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|
gi 124302198  1516 LGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEE 1555
Cdd:pfam05557  436 PSYSKEEVDSLRRKLETLELERQRLREQKNELEMELERRC 475
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
1496-1851 6.20e-05

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 47.97  E-value: 6.20e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1496 ETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQsalEEAEASLEHEEGKILRAQLEFNQIKAEIERK 1575
Cdd:pfam07888   69 EQWERQRRELESRVAELKEELRQSREKHEELEEKYKELSASSEELS---EEKDALLAQRAAHEARIRELEEDIKTLTQRV 145
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1576 LaEKDEEMEQAKRNHLRVVDSLQtsldaETRSRNEALRVK-KKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQ 1654
Cdd:pfam07888  146 L-ERETELERMKERAKKAGAQRK-----EEEAERKQLQAKlQQTEEELRSLSKEFQELRNSLAQRDTQVLQLQDTITTLT 219
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1655 IQLDDAvranddlkeniaivERRNNLLQAELEELRAVveqtersrklaeQELIETSER-VQLLHSQNTSLINQKKKMDAD 1733
Cdd:pfam07888  220 QKLTTA--------------HRKEAENEALLEELRSL------------QERLNASERkVEGLGEELSSMAAQRDRTQAE 273
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1734 LSQLQTEVEE----------AVQECRNAEEKAKKAITDAAMMAEElkKEQDTSAHLERMKKNMEQTIKDLQH------RL 1797
Cdd:pfam07888  274 LHQARLQAAQltlqladaslALREGRARWAQERETLQQSAEADKD--RIEKLSAELQRLEERLQEERMEREKlevelgRE 351
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....
gi 124302198  1798 DEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELT 1851
Cdd:pfam07888  352 KDCNRVQLSESRRELQELKASLRVAQKEKEQLQAEKQELLEYIRQLEQRLETVA 405
PRK01156 PRK01156
chromosome segregation protein; Provisional
1048-1586 6.52e-05

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 47.97  E-value: 6.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1048 LERAKRKLEGDLKLTQESIMDLENdkqqLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERT 1127
Cdd:PRK01156  164 LERNYDKLKDVIDMLRAEISNIDY----LEEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDYNNLKS 239
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1128 A--------------RAKVEKLRSDLSRELEE---ISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAA 1190
Cdd:PRK01156  240 AlnelssledmknryESEIKTAESDLSMELEKnnyYKELEERHMKIINDPVYKNRNYINDYFKYKNDIENKKQILSNIDA 319
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1191 ALRKKHADSVAELGEQIDNLQRVKQKleKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSV 1270
Cdd:PRK01156  320 EINKYHAIIKKLSVLQKDYNDYIKKK--SRYDDLNNQILELEGYEMDYNSYLKSIESLKKKIEEYSKNIERMSAFISEIL 397
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1271 NDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLE---------------EEVKAKNALAH---A 1332
Cdd:PRK01156  398 KIQEIDPDAIKKELNEINVKLQDISSKVSSLNQRIRALRENLDELSRNMEmlngqsvcpvcgttlGEEKSNHIINHyneK 477
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1333 LQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAqRLQEAEEAVEAVNAKCS 1412
Cdd:PRK01156  478 KSRLEEKIREIEIEVKDIDEKIVDLKKRKEYLESEEINKSINEYNKIESARADLEDIKIKIN-ELKDKHDKYEEIKNRYK 556
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1413 SLEKTKHRLQNEiEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESL 1492
Cdd:PRK01156  557 SLKLEDLDSKRT-SWLNALAVISLIDIETNRSRSNEIKKQLNDLESRLQEIEIGFPDDKSYIDKSIREIENEANNLNNKY 635
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1493 EHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQL---EAEKMELQSALEEAEASLEHEEG--KILRAQL-EFN 1566
Cdd:PRK01156  636 NEIQENKILIEKLRGKIDNYKKQIAEIDSIIPDLKEITSRIndiEDNLKKSRKALDDAKANRARLEStiEILRTRInELS 715
                         570       580
                  ....*....|....*....|
gi 124302198 1567 QIKAEIERKLaEKDEEMEQA 1586
Cdd:PRK01156  716 DRINDINETL-ESMKKIKKA 734
PRK12704 PRK12704
phosphodiesterase; Provisional
1020-1170 6.82e-05

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 47.85  E-value: 6.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1020 LTKAKVKLEQQVDDLEGSLEQEKK-----VRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARI 1094
Cdd:PRK12704   33 IKEAEEEAKRILEEAKKEAEAIKKealleAKEEIHKLRNEFEKELRERRNELQKLEKRLLQKEENLDRKLELLEKREEEL 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1095 EDEQALGSQLQKKLKELQARIEELEEEleaertARAKVEKLrSDLSRE------LEEISERLEEAGGATSVQIEMNKKRE 1168
Cdd:PRK12704  113 EKKEKELEQKQQELEKKEEELEELIEE------QLQELERI-SGLTAEeakeilLEKVEEEARHEAAVLIKEIEEEAKEE 185

                  ..
gi 124302198 1169 AE 1170
Cdd:PRK12704  186 AD 187
CCDC73 pfam15818
Coiled-coil domain-containing protein 73 family; CCDC73 is a family of eukaryotic coiled-coil ...
765-1110 6.85e-05

Coiled-coil domain-containing protein 73 family; CCDC73 is a family of eukaryotic coiled-coil containing proteins. The function is not known. The alternative name is sarcoma antigen NY-SAR-79.


Pssm-ID: 464893 [Multi-domain]  Cd Length: 1048  Bit Score: 48.02  E-value: 6.85e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   765 FKAGLLGLLEEMR---------DERLSRIITRIQaqsrgvlaRMEYKKLLERRDSLLVIQWNIRAFMGVKNWPWMKLYF- 834
Cdd:pfam15818    5 FKTSLLEALEELRmrreaetqyEEQIGKIIVETQ--------ELKWQKETLQNQKETLAKQHKEAMAVFKKQLQMKMCAl 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   835 ---KIKPLLKSAEREKEMASmkeeftrLKEALEKSEARRKELEEKmVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKN 911
Cdd:pfam15818   77 eeeKGKYQLATEIKEKEIEG-------LKETLKALQVSKYSLQKK-VSEMEQKLQLHLLAKEDHHKQLNEIEKYYATITG 148
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   912 KIQLeakVKEMNERLE----DEEEMNAELTAKKRKLEDECSELKRDIDDL--ELTLAKVE-KEKHATEN--------KVK 976
Cdd:pfam15818  149 QFGL---VKENHGKLEqnvqEAIQLNKRLSALNKKQESEICSLKKELKKVtsDLIKSKVTcQYKMGEENinltikeqKFQ 225
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   977 NLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEgslEQEKKVRMDLERAKRKLe 1056
Cdd:pfam15818  226 ELQERLNMELELNKKINEEITHIQEEKQDIIISFQHMQQLLQQQTQANTEMEAELKALK---ENNQTLERDNELQREKV- 301
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....
gi 124302198  1057 gdlKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKE 1110
Cdd:pfam15818  302 ---KENEEKFLNLQNEHEKALGTWKKHVEELNGEINEIKNELSSLKETHIKLQE 352
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1595-1807 7.14e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 47.45  E-value: 7.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1595 DSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIV 1674
Cdd:COG4942    30 EQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEELAEL 109
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1675 ER------RNNLLQ--------AELEELRAVVEQTERSRKLAEQELIETSERvqlLHSQNTSLINQKKKMDADLSQLQTE 1740
Cdd:COG4942   110 LRalyrlgRQPPLAlllspedfLDAVRRLQYLKYLAPARREQAEELRADLAE---LAALRAELEAERAELEALLAELEEE 186
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 124302198 1741 VEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKG 1807
Cdd:COG4942   187 RAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAAGFAALKG 253
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
1226-1397 7.65e-05

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 46.07  E-value: 7.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1226 LELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGK 1305
Cdd:COG1579    10 LDLQELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVRNNK 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1306 ltytqQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEE 1385
Cdd:COG1579    90 -----EYEALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAE 164
                         170
                  ....*....|..
gi 124302198 1386 LEEAKKKLAQRL 1397
Cdd:COG1579   165 REELAAKIPPEL 176
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
871-1223 7.80e-05

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 47.20  E-value: 7.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  871 KELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSEL 950
Cdd:COG4372     6 EKVGKARLSLFGLRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEEL 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  951 KRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQ 1030
Cdd:COG4372    86 NEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEE 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1031 VDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKE 1110
Cdd:COG4372   166 LAALEQELQALSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELE 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1111 LQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAA 1190
Cdd:COG4372   246 EDKEELLEEVILKEIEELELAILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALLELA 325
                         330       340       350
                  ....*....|....*....|....*....|...
gi 124302198 1191 ALRKKHADSVAELGEQIDNLQRVKQKLEKEKSE 1223
Cdd:COG4372   326 KKLELALAILLAELADLLQLLLVGLLDNDVLEL 358
HCR pfam07111
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ...
867-1334 8.23e-05

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.


Pssm-ID: 284517 [Multi-domain]  Cd Length: 749  Bit Score: 47.82  E-value: 8.23e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   867 EARRKELEEKMVSLLQEKNDLQLQVQAEQDNLadaeercdQLIKNKIQLEAkvKEMNERLEDEEEMNAELTAKKRKLede 946
Cdd:pfam07111  241 ELERQELLDTMQHLQEDRADLQATVELLQVRV--------QSLTHMLALQE--EELTRKIQPSDSLEPEFPKKCRSL--- 307
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   947 cseLKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTL------ 1020
Cdd:pfam07111  308 ---LNRWREKVFALMVQLKAQDLEHRDSVKQLRGQVAELQEQVTSQSQEQAILQRALQDKAAEVEVERMSAKGLqmelsr 384
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1021 -TKAKVKLEQQVDDLEgslEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKkdfelnalnariedeqa 1099
Cdd:pfam07111  385 aQEARRRQQQQTASAE---EQLKFVVNAMSSTQIWLETTMTRVEQAVARIPSLSNRLSYAVRK----------------- 444
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1100 lgsqlQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISE---RL--EEAGGATSVQIEMNKKREaEFQKM 1174
Cdd:pfam07111  445 -----VHTIKGLMARKVALAQLRQESCPPPPPAPPVDADLSLELEQLREernRLdaELQLSAHLIQQEVGRARE-QGEAE 518
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1175 RRDLEEATLQHEATAaalrKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDV-----TSNMEQIIKAKANLEKMC 1249
Cdd:pfam07111  519 RQQLSEVAQQLEQEL----QRAQESLASVGQQLEVARQGQQESTEEAASLRQELTQQqeiygQALQEKVAEVETRLREQL 594
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1250 RTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEalisqltrgkltyTQQLEDLKRQLEEEVKAKNAL 1329
Cdd:pfam07111  595 SDTKRRLNEARREQAKAVVSLRQIQHRATQEKERNQELRRLQDEAR-------------KEEGQRLARRVQELERDKNLM 661

                   ....*
gi 124302198  1330 AHALQ 1334
Cdd:pfam07111  662 LATLQ 666
CHASE3 COG5278
Extracytoplasmic sensor domain CHASE3 (specificity unknown) [Signal transduction mechanisms];
1493-1932 8.75e-05

Extracytoplasmic sensor domain CHASE3 (specificity unknown) [Signal transduction mechanisms];


Pssm-ID: 444089 [Multi-domain]  Cd Length: 530  Bit Score: 47.59  E-value: 8.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1493 EHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSAL--------EEAEASLEHEEGKILRAQLE 1564
Cdd:COG5278    76 SFLEPYEEARAEIDELLAELRSLTADNPEQQARLDELEALIDQWLAELEQVIalrragglEAALALVRSGEGKALMDEIR 155
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1565 FNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVK 1644
Cdd:COG5278   156 ARLLLLALALAALLLAAAALLLLLLALAALLALAELLLLALARALAALLLLLLLEAELAAAAALLAAAAALAALAALELL 235
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1645 SLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLI 1724
Cdd:COG5278   236 AALALALALLLAALLLALLAALALAALLAAALLALAALLLALAAAAALAAAAALELAAAEALALAELELELLLAAAAAAA 315
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1725 NQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIA 1804
Cdd:COG5278   316 AAAAAAAAALAALLALALATALAAAAAALALLAALLAEAAAAAAEEAEAAAEAAAAALAGLAEVEAEGAAEAVELEVLAI 395
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1805 LKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEE 1884
Cdd:COG5278   396 AAAAAAAAAEAAAAAAAAAAASAAEALELAEALAEALALAEEEALALAAASSELAEAGAALALAAAEALAEELAAVAALA 475
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 124302198 1885 AEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGTKGL 1932
Cdd:COG5278   476 ALAAAAAALAEAEAAAALAAAAALSLALALAALLLAAAEAALAAALAA 523
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
1422-1922 9.51e-05

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 47.43  E-value: 9.51e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1422 QNEIEDLMVDVERSNAAAAALDKKQRNFDKILAewKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLEtfkRE 1501
Cdd:pfam05557   20 QMELEHKRARIELEKKASALKRQLDRESDRNQE--LQKRIRLLEKREAEAEEALREQAELNRLKKKYLEALNKKL---NE 94
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1502 NKNLQEEISDLTEQLGSsgktihELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQlEFNQIKAEIERKLAEKDE 1581
Cdd:pfam05557   95 KESQLADAREVISCLKN------ELSELRRQIQRAELELQSTNSELEELQERLDLLKAKAS-EAEQLRQNLEKQQSSLAE 167
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1582 EMEQAKrnHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMaaeaqkqvKSLQSLLKDTQIQLDDAV 1661
Cdd:pfam05557  168 AEQRIK--ELEFEIQSQEQDSEIVKNSKSELARIPELEKELERLREHNKHLNEN--------IENKLLLKEEVEDLKRKL 237
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1662 RANDDLKENIAIVERRNNLLQAELEELravvEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEV 1741
Cdd:pfam05557  238 EREEKYREEAATLELEKEKLEQELQSW----VKLAQDTGLNLRSPEDLSRRIEQLQQREIVLKEENSSLTSSARQLEKAR 313
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1742 EEAVQECRNAEEKakkaITDAAMMAEELK--------------KEQD-TSAHLERMKK--NMEQTIKDLQHRLDEAEQIA 1804
Cdd:pfam05557  314 RELEQELAQYLKK----IEDLNKKLKRHKalvrrlqrrvllltKERDgYRAILESYDKelTMSNYSPQLLERIEEAEDMT 389
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1805 LKGgKKQLQKLEARVRELENELEAEQKRNA--ESVKGMRKSERRIKELTYQTEED---RKNLLRLQDLVDKLQLKVKAYK 1879
Cdd:pfam05557  390 QKM-QAHNEEMEAQLSVAEEELGGYKQQAQtlERELQALRQQESLADPSYSKEEVdslRRKLETLELERQRLREQKNELE 468
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|...
gi 124302198  1880 RQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRA 1922
Cdd:pfam05557  469 MELERRCLQGDYDPKKTKVLHLSMNPAAEAYQQRKNQLEKLQA 511
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
1071-1242 9.78e-05

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 46.07  E-value: 9.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1071 NDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERL 1150
Cdd:COG1579     3 PEDLRALLDLQELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQL 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1151 EEAGG-----ATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFK 1225
Cdd:COG1579    83 GNVRNnkeyeALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELE 162
                         170
                  ....*....|....*..
gi 124302198 1226 LELDDVTSNMEQIIKAK 1242
Cdd:COG1579   163 AEREELAAKIPPELLAL 179
DUF4686 pfam15742
Domain of unknown function (DUF4686); This family of proteins is found in eukaryotes. Proteins ...
839-1083 9.92e-05

Domain of unknown function (DUF4686); This family of proteins is found in eukaryotes. Proteins in this family are typically between 498 and 775 amino acids in length. There is a conserved DLK sequence motif.


Pssm-ID: 464838 [Multi-domain]  Cd Length: 384  Bit Score: 46.98  E-value: 9.92e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   839 LLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQ---------EKNDLQLQVQAEQDNLADAEERCDQLI 909
Cdd:pfam15742   99 VLKQAQSIKSQNSLQEKLAQEKSRVADAEEKILELQQKLEHAHKvcltdtcilEKKQLEERIKEASENEAKLKQQYQEEQ 178
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   910 KNKIQLEAKVKEMNERLEDeeemnaeLTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEemagLDEII 989
Cdd:pfam15742  179 QKRKLLDQNVNELQQQVRS-------LQDKEAQLEMTNSQQQLRIQQQEAQLKQLENEKRKSDEHLKSNQE----LSEKL 247
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   990 AKLTKEKKALQEAHQQALDDLQAEEDKVNtltkakvkleqqvddlegslEQEKKVRMDLERAKRKLEGDLKLTQESIMDL 1069
Cdd:pfam15742  248 SSLQQEKEALQEELQQVLKQLDVHVRKYN--------------------EKHHHHKAKLRRAKDRLVHEVEQRDERIKQL 307
                          250
                   ....*....|....
gi 124302198  1070 ENDKQQLDERLKKK 1083
Cdd:pfam15742  308 ENEIGILQQQSEKE 321
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
1702-1889 1.07e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 46.75  E-value: 1.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1702 AEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDT-SAHLE 1780
Cdd:COG3883    14 ADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREElGERAR 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1781 RMKKNMEQT-----------IKDLQHRLDEAEQIAlKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKE 1849
Cdd:COG3883    94 ALYRSGGSVsyldvllgsesFSDFLDRLSALSKIA-DADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKAE 172
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 124302198 1850 LTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQA 1889
Cdd:COG3883   173 LEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAA 212
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
830-1321 1.07e-04

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 47.43  E-value: 1.07e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   830 MKLYFKIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEkndLQLQVQ----------------- 892
Cdd:pfam05557  125 LELQSTNSELEELQERLDLLKAKASEAEQLRQNLEKQQSSLAEAEQRIKELEFE---IQSQEQdseivknskselaripe 201
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   893 --AEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTA---KKRKLEDECSELKRDIDDLELTLAKVEke 967
Cdd:pfam05557  202 leKELERLREHNKHLNENIENKLLLKEEVEDLKRKLEREEKYREEAATlelEKEKLEQELQSWVKLAQDTGLNLRSPE-- 279
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   968 khATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQalddlqaeedkvntltkakvkLEQQVDDLEGSLEQEKKVRMD 1047
Cdd:pfam05557  280 --DLSRRIEQLQQREIVLKEENSSLTSSARQLEKARRE---------------------LEQELAQYLKKIEDLNKKLKR 336
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1048 LERAKRKLegdlkltQESIMDLENDKQQLDERLKKKDFELNALNAriedeqalGSQLQKKLKELqarieeleeeleaert 1127
Cdd:pfam05557  337 HKALVRRL-------QRRVLLLTKERDGYRAILESYDKELTMSNY--------SPQLLERIEEA---------------- 385
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1128 arakvEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDleeatlqheaTAAALRKKHADSVAELGEQI 1207
Cdd:pfam05557  386 -----EDMTQKMQAHNEEMEAQLSVAEEELGGYKQQAQTLERELQALRQQ----------ESLADPSYSKEEVDSLRRKL 450
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1208 DNLQRVKQKLEKEKSEFKLELddvtsnMEQIIKAKANLEKmCRTLEDQMNehrSKAEETQRSVNDLTsqraKLQTENGEL 1287
Cdd:pfam05557  451 ETLELERQRLREQKNELEMEL------ERRCLQGDYDPKK-TKVLHLSMN---PAAEAYQQRKNQLE----KLQAEIERL 516
                          490       500       510
                   ....*....|....*....|....*....|....*...
gi 124302198  1288 SRQL----DEKEALISQLTRGKLTYTQQLEDLKRQLEE 1321
Cdd:pfam05557  517 KRLLkkleDDLEQVLRLPETTSTMNFKEVLDLRKELES 554
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
981-1159 1.15e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 45.69  E-value: 1.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  981 EMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEgSLEQEKKVRMDLERAKRKLEGdlk 1060
Cdd:COG1579    18 ELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVE-ARIKKYEEQLGNVRNNKEYEA--- 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1061 LTQEsIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTA-RAKVEKLRSDL 1139
Cdd:COG1579    94 LQKE-IESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEElEAEREELAAKI 172
                         170       180
                  ....*....|....*....|
gi 124302198 1140 SRELEEISERLEEAGGATSV 1159
Cdd:COG1579   173 PPELLALYERIRKRKNGLAV 192
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1477-1656 1.20e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 46.93  E-value: 1.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1477 LSTELFKLKNAYEESLEHLETFKRENKnlqeeISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEG 1556
Cdd:COG3206   180 LEEQLPELRKELEEAEAALEEFRQKNG-----LVDLSEEAKLLLQQLSELESQLAEARAELAEAEARLAALRAQLGSGPD 254
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1557 KI--LRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVV------DSLQTSLDAET--------------RSRNEALR- 1613
Cdd:COG3206   255 ALpeLLQSPVIQQLRAQLAELEAELAELSARYTPNHPDVIalraqiAALRAQLQQEAqrilasleaelealQAREASLQa 334
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 124302198 1614 ----VKKKMEgDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQ 1656
Cdd:COG3206   335 qlaqLEARLA-ELPELEAELRRLEREVEVARELYESLLQRLEEARLA 380
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
859-995 1.32e-04

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 46.77  E-value: 1.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  859 LKEALEKSEARRKELEEKmvsllqeknDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTA 938
Cdd:COG2433   378 IEEALEELIEKELPEEEP---------EAEREKEHEERELTEEEEEIRRLEEQVERLEAEVEELEAELEEKDERIERLER 448
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 124302198  939 KKRKL----------EDECSELKRDIDDLELTLAKVEKEKHATENKVKNLtEEMAGLDE--------IIAKLTKE 995
Cdd:COG2433   449 ELSEArseerreirkDREISRLDREIERLERELEEERERIEELKRKLERL-KELWKLEHsgelvpvkVVEKFTKE 522
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
873-1111 1.46e-04

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 46.84  E-value: 1.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  873 LEEKMVSLLQEKNDLQLqVQAEQDNLADAEERcdqlIKNKIQLEAKVKEMNERLEDEeeMNAELTAKKRKLEDECSELKR 952
Cdd:PRK05771   14 LKSYKDEVLEALHELGV-VHIEDLKEELSNER----LRKLRSLLTKLSEALDKLRSY--LPKLNPLREEKKKVSVKSLEE 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  953 DIDDLELTLAKVEKEkhatenkVKNLTEEMAGLDEIIAKLTKEKKALQ--EAHQQALDDLQAEED---KVNTLTKAKVKL 1027
Cdd:PRK05771   87 LIKDVEEELEKIEKE-------IKELEEEISELENEIKELEQEIERLEpwGNFDLDLSLLLGFKYvsvFVGTVPEDKLEE 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1028 EQQVDDLEGSLEQEKK------VRMDLERAKRKLEGDLKLTQESIMDLENDKqQLDERLKKKDFELNALNARIEDeqalg 1101
Cdd:PRK05771  160 LKLESDVENVEYISTDkgyvyvVVVVLKELSDEVEEELKKLGFERLELEEEG-TPSELIREIKEELEEIEKERES----- 233
                         250
                  ....*....|
gi 124302198 1102 sqLQKKLKEL 1111
Cdd:PRK05771  234 --LLEELKEL 241
HCR pfam07111
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ...
859-1399 1.57e-04

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.


Pssm-ID: 284517 [Multi-domain]  Cd Length: 749  Bit Score: 46.67  E-value: 1.57e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   859 LKEALEKSEARRKELEEKMVSLLQE-----KNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAK----VKEM------- 922
Cdd:pfam07111  120 LRAALAGAEMVRKNLEEGSQRELEEiqrlhQEQLSSLTQAHEEALSSLTSKAEGLEKSLNSLETKrageAKQLaeaqkea 199
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   923 ----NERLEDEEEMNAELT-----------------------AKKRKLEDECSELKRDIDDL----ELTLAKVEKEKHAT 971
Cdd:pfam07111  200 ellrKQLSKTQEELEAQVTlveslrkyvgeqvppevhsqtweLERQELLDTMQHLQEDRADLqatvELLQVRVQSLTHML 279
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   972 ENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQA----LDDLQAEE----DKVNTLTKAKVKLEQQVDD-------LEG 1036
Cdd:pfam07111  280 ALQEEELTRKIQPSDSLEPEFPKKCRSLLNRWREKvfalMVQLKAQDlehrDSVKQLRGQVAELQEQVTSqsqeqaiLQR 359
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1037 SLeQEKKVRMDLERAKRK-LEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARI 1115
Cdd:pfam07111  360 AL-QDKAAEVEVERMSAKgLQMELSRAQEARRRQQQQTASAEEQLKFVVNAMSSTQIWLETTMTRVEQAVARIPSLSNRL 438
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1116 EEleeeleaertARAKVEKLRSDLSRELEEISERLEEAGGATSV-QIEMNKKREAEFQKMRRDLEEATLQheaTAAALRK 1194
Cdd:pfam07111  439 SY----------AVRKVHTIKGLMARKVALAQLRQESCPPPPPApPVDADLSLELEQLREERNRLDAELQ---LSAHLIQ 505
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1195 KHADSVAELGE-QIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKanlekmcrtledqmnehrskaeetQRSVNDL 1273
Cdd:pfam07111  506 QEVGRAREQGEaERQQLSEVAQQLEQELQRAQESLASVGQQLEVARQGQ------------------------QESTEEA 561
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1274 TSQRAKLQTENGELSRQLDEKEALISQLTRgkltytQQLEDLKRQLEEevkAKNALAHALQSARHdcdlLREQYEEETEA 1353
Cdd:pfam07111  562 ASLRQELTQQQEIYGQALQEKVAEVETRLR------EQLSDTKRRLNE---ARREQAKAVVSLRQ----IQHRATQEKER 628
                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....*.
gi 124302198  1354 KAELQRVLSKANSEVAQWRTKyetdaiqRTEELEEAKKKLAQRLQE 1399
Cdd:pfam07111  629 NQELRRLQDEARKEEGQRLAR-------RVQELERDKNLMLATLQQ 667
PRK01156 PRK01156
chromosome segregation protein; Provisional
1378-1923 1.58e-04

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 46.82  E-value: 1.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1378 DAIQRTEELEEAKKKLaqrlqeaEEAVEAVNAKCSSLEKTKHRLQNEIEDlmvdVERSNAAAAALDKKQRNFDKILAEWK 1457
Cdd:PRK01156  156 DEILEINSLERNYDKL-------KDVIDMLRAEISNIDYLEEKLKSSNLE----LENIKKQIADDEKSHSITLKEIERLS 224
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1458 QKYEESQSELESSQKEARSLSTeLFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLG--------SSGKTIHELEKV 1529
Cdd:PRK01156  225 IEYNNAMDDYNNLKSALNELSS-LEDMKNRYESEIKTAESDLSMELEKNNYYKELEERHMkiindpvyKNRNYINDYFKY 303
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1530 RKQLEAEKMELQSAleEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRN 1609
Cdd:PRK01156  304 KNDIENKKQILSNI--DAEINKYHAIIKKLSVLQKDYNDYIKKKSRYDDLNNQILELEGYEMDYNSYLKSIESLKKKIEE 381
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1610 EALRVKK---KMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRN-------- 1678
Cdd:PRK01156  382 YSKNIERmsaFISEILKIQEIDPDAIKKELNEINVKLQDISSKVSSLNQRIRALRENLDELSRNMEMLNGQSvcpvcgtt 461
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1679 ----------NLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTS-LINQKKKMDADLSQLqTEVEEAVQE 1747
Cdd:PRK01156  462 lgeeksnhiiNHYNEKKSRLEEKIREIEIEVKDIDEKIVDLKKRKEYLESEEINkSINEYNKIESARADL-EDIKIKINE 540
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1748 CRNAEEKAKKAITDAAMMAEELKKEQDTSaHLERMKKNMEQTIKDLQHRLDEAeqialkggKKQLQKLEARVRELENELE 1827
Cdd:PRK01156  541 LKDKHDKYEEIKNRYKSLKLEDLDSKRTS-WLNALAVISLIDIETNRSRSNEI--------KKQLNDLESRLQEIEIGFP 611
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1828 AEQKRNAESVkgmrkseRRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQA---EEAEEQANTNLSKFRKVQHELD 1904
Cdd:PRK01156  612 DDKSYIDKSI-------REIENEANNLNNKYNEIQENKILIEKLRGKIDNYKKQIaeiDSIIPDLKEITSRINDIEDNLK 684
                         570
                  ....*....|....*....
gi 124302198 1905 EAEERADIAESQVNKLRAK 1923
Cdd:PRK01156  685 KSRKALDDAKANRARLEST 703
mukB PRK04863
chromosome partition protein MukB;
1539-1920 1.61e-04

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 46.87  E-value: 1.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1539 ELQSALEEAeASLEHEEGKILRAQLEFNQIKAEIERKLA-----EKDEEME-QAKRNHLRVVdslqtsldaetrsrNEAL 1612
Cdd:PRK04863  280 ERRVHLEEA-LELRRELYTSRRQLAAEQYRLVEMARELAelneaESDLEQDyQAASDHLNLV--------------QTAL 344
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1613 RVKKKME---GDLNEMEIQLSHANRMAAEAQKQ--------------VKSLQSLLKDTQIQLDDAVRANDDLKENIAIVE 1675
Cdd:PRK04863  345 RQQEKIEryqADLEELEERLEEQNEVVEEADEQqeenearaeaaeeeVDELKSQLADYQQALDVQQTRAIQYQQAVQALE 424
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1676 RRNNLLQA---ELEELRAVVEQTERSRKLAEQELIETSERVQLlhSQNTSliNQKKKMDADLSQLQTEVEEAVqecrnAE 1752
Cdd:PRK04863  425 RAKQLCGLpdlTADNAEDWLEEFQAKEQEATEELLSLEQKLSV--AQAAH--SQFEQAYQLVRKIAGEVSRSE-----AW 495
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1753 EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTiKDLQHRLDEAEQIALKG--GKKQLQKLEARVRELENELEAEQ 1830
Cdd:PRK04863  496 DVARELLRRLREQRHLAEQLQQLRMRLSELEQRLRQQ-QRAERLLAEFCKRLGKNldDEDELEQLQEELEARLESLSESV 574
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1831 KRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERA 1910
Cdd:PRK04863  575 SEARERRMALRQQLEQLQARIQRLAARAPAWLAAQDALARLREQSGEEFEDSQDVTEYMQQLLERERELTVERDELAARK 654
                         410
                  ....*....|
gi 124302198 1911 DIAESQVNKL 1920
Cdd:PRK04863  655 QALDEEIERL 664
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
911-1180 1.70e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 46.66  E-value: 1.70e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   911 NKIQLEAKVKEM-NERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDeiI 989
Cdd:pfam17380  285 SERQQQEKFEKMeQERLRQEKEEKAREVERRRKLEEAEKARQAEMDRQAAIYAEQERMAMERERELERIRQEERKRE--L 362
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   990 AKLTKEKKALQEAHQQALDDLQAEEDKVN--------TLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAK----RKLEG 1057
Cdd:pfam17380  363 ERIRQEEIAMEISRMRELERLQMERQQKNervrqeleAARKVKILEEERQRKIQQQKVEMEQIRAEQEEARqrevRRLEE 442
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1058 DLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQalgsQLQKKLKELQARIEELEEEleAERTARAKVEKLRS 1137
Cdd:pfam17380  443 ERAREMERVRLEEQERQQQVERLRQQEEERKRKKLELEKEK----RDRKRAEEQRRKILEKELE--ERKQAMIEEERKRK 516
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*....
gi 124302198  1138 DLSRELEEIS------ERLEEAGGATSVQIEMNKKREAEfQKMRRDLEE 1180
Cdd:pfam17380  517 LLEKEMEERQkaiyeeERRREAEEERRKQQEMEERRRIQ-EQMRKATEE 564
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
1534-1763 1.72e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 45.98  E-value: 1.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1534 EAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQakrnhlrvVDSLQTSLDaetrsrnealr 1613
Cdd:COG3883    15 DPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAE--------IDKLQAEIA----------- 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1614 vkkKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIqlDDAVRANDDLKeniAIVERRNNLLQaELEELRAVVE 1693
Cdd:COG3883    76 ---EAEAEIEERREELGERARALYRSGGSVSYLDVLLGSESF--SDFLDRLSALS---KIADADADLLE-ELKADKAELE 146
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1694 QTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAA 1763
Cdd:COG3883   147 AKKAELEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAA 216
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
1374-1888 1.76e-04

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 46.89  E-value: 1.76e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1374 KYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRnfdkiL 1453
Cdd:TIGR00618  177 QYTQLALMEFAKKKSLHGKAELLTLRSQLLTLCTPCMPDTYHERKQVLEKELKHLREALQQTQQSHAYLTQKRE-----A 251
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1454 AEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEES------LEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELE 1527
Cdd:TIGR00618  252 QEEQLKKQQLLKQLRARIEELRAQEAVLEETQERINRArkaaplAAHIKAVTQIEQQAQRIHTELQSKMRSRAKLLMKRA 331
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1528 KVRKQ---LEAEKMELQSAL-EEAEASLEHEEGKILRAQLEfnQIKAEIERKLA-----EKDEEMEQAKRNHLRVVDSLQ 1598
Cdd:TIGR00618  332 AHVKQqssIEEQRRLLQTLHsQEIHIRDAHEVATSIREISC--QQHTLTQHIHTlqqqkTTLTQKLQSLCKELDILQREQ 409
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1599 TSLDAETRSRNEALRVKKKMEGdlnEMEIQLSHANRMAAEAQKQVKSLqsllKDTQIQLDDAVRANDDLKENIAIVErrn 1678
Cdd:TIGR00618  410 ATIDTRTSAFRDLQGQLAHAKK---QQELQQRYAELCAAAITCTAQCE----KLEKIHLQESAQSLKEREQQLQTKE--- 479
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1679 NLLQAELE----ELRAVVEQTERSRKLAEQELIETSERVQLLHSQ-NTSLINQKKKMDADLSQLQTEVEEAVQECRNAEE 1753
Cdd:TIGR00618  480 QIHLQETRkkavVLARLLELQEEPCPLCGSCIHPNPARQDIDNPGpLTRRMQRGEQTYAQLETSEEDVYHQLTSERKQRA 559
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1754 KAKKAITDAamMAEELKKEQDTSAHLERMKK--NMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQK 1831
Cdd:TIGR00618  560 SLKEQMQEI--QQSFSILTQCDNRSKEDIPNlqNITVRLQDLTEKLSEAEDMLACEQHALLRKLQPEQDLQDVRLHLQQC 637
                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 124302198  1832 RNAESVKGMRKsERRIKELTYQTEEDRKNLLRLQDlvdklqlKVKAYKRQAEEAEEQ 1888
Cdd:TIGR00618  638 SQELALKLTAL-HALQLTLTQERVREHALSIRVLP-------KELLASRQLALQKMQ 686
COG5022 COG5022
Myosin heavy chain [General function prediction only];
1321-1623 1.90e-04

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 46.61  E-value: 1.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1321 EEVKAKNALAHALQSARHDCDLLREQYEEETEAKAE--LQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLaQRLQ 1398
Cdd:COG5022   810 KEYRSYLACIIKLQKTIKREKKLRETEEVEFSLKAEvlIQKFGRSLKAKKRFSLLKKETIYLQSAQRVELAERQL-QELK 888
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1399 EAEEAVEAVNAKCSSLEKTKHRLQNEIE-DLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKeaRSL 1477
Cdd:COG5022   889 IDVKSISSLKLVNLELESEIIELKKSLSsDLIENLEFKTELIARLKKLLNNIDLEEGPSIEYVKLPELNKLHEVE--SKL 966
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1478 STELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGkTIHELEKVRKQLEAEKMELQSAleEAEASLEHEEGK 1557
Cdd:COG5022   967 KETSEEYEDLLKKSTILVREGNKANSELKNFKKELAELSKQYG-ALQESTKQLKELPVEVAELQSA--SKIISSESTELS 1043
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 124302198 1558 ILR--AQLEFNQIKAeiERKLAEKDEEMEQAKRNHLRvvDSLQTSLDAETRSRNEALRVKKKMEGDLN 1623
Cdd:COG5022  1044 ILKplQKLKGLLLLE--NNQLQARYKALKLRRENSLL--DDKQLYQLESTENLLKTINVKDLEVTNRN 1107
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
777-1326 2.01e-04

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 46.58  E-value: 2.01e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   777 RDERLSRIITRIQAQSRGVLARMEYKKLLER------------RDSLLVIQWNIRAFMGVKNWPWMKLYFKIKPLLKSAE 844
Cdd:TIGR00606  547 KDEQIRKIKSRHSDELTSLLGYFPNKKQLEDwlhskskeinqtRDRLAKLNKELASLEQNKNHINNELESKEEQLSSYED 626
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   845 REKEMASMKEEFTRLKEALEKSEARRKELeekmvSLLQEKNDLQLQVQAEqdnLADAEERCDQLIKNKIQLEakvKEMNE 924
Cdd:TIGR00606  627 KLFDVCGSQDEESDLERLKEEIEKSSKQR-----AMLAGATAVYSQFITQ---LTDENQSCCPVCQRVFQTE---AELQE 695
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   925 RLEDEEEMNAELTAKKRKLEDECSELKRDIDDL-------ELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKK 997
Cdd:TIGR00606  696 FISDLQSKLRLAPDKLKSTESELKKKEKRRDEMlglapgrQSIIDLKEKEIPELRNKLQKVNRDIQRLKNDIEEQETLLG 775
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   998 AL---QEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEG-----SLEQEKKVRMDLERAKRKLEGDLKLTQESImdl 1069
Cdd:TIGR00606  776 TImpeEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGsdldrTVQQVNQEKQEKQHELDTVVSKIELNRKLI--- 852
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1070 eNDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISER 1149
Cdd:TIGR00606  853 -QDQQEQIQHLKSKTNELKSEKLQIGTNLQRRQQFEEQLVELSTEVQSLIREIKDAKEQDSPLETFLEKDQQEKEELISS 931
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1150 LEEAGGATSVQIEMNKKREAEFQKMRRDLEEATlqhEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKeksEFKLELD 1229
Cdd:TIGR00606  932 KETSNKKAQDKVNDIKEKVKNIHGYMKDIENKI---QDGKDDYLKQKETELNTVNAQLEECEKHQEKINE---DMRLMRQ 1005
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1230 DVTSNMEQIIKAKANLEKMCRtledqmnehRSKAEETQRSVNDLTSQRAKLQ-TENGELSRQLDEKEALISQLTRGKLTY 1308
Cdd:TIGR00606 1006 DIDTQKIQERWLQDNLTLRKR---------ENELKEVEEELKQHLKEMGQMQvLQMKQEHQKLEENIDLIKRNHVLALGR 1076
                          570
                   ....*....|....*...
gi 124302198  1309 TQQLEDLKRQLEEEVKAK 1326
Cdd:TIGR00606 1077 QKGYEKEIKHFKKELREP 1094
CagA_N pfam18971
CagA protein; The Helicobacter pylori type IV secretion effector CagA is a major bacterial ...
859-1085 2.07e-04

CagA protein; The Helicobacter pylori type IV secretion effector CagA is a major bacterial virulence determinant and critical for gastric carcinogenesis. X-ray crystallographic analysis of the N-terminal CagA fragment (residues 1-876) revealed that the region has a structure comprised of three discrete domains. Domain I constitutes a mobile CagA N terminus, while Domain II tethers CagA to the plasma membrane by interacting with membrane phosphatidylserine. Domain III interacts intramolecularly with the intrinsically disordered C-terminal region, and this interaction potentiates the pathogenic scaffold/hub function of CagA.


Pssm-ID: 408741 [Multi-domain]  Cd Length: 876  Bit Score: 46.30  E-value: 2.07e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   859 LKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDnladaEERCDQLIKNKIQLEAKVKEMNERLEdeeemnaeltA 938
Cdd:pfam18971  619 LEKSLRKREHLEKEVEKKLESKSGNKNKMEAKAQANSQ-----KDEIFALINKEANRDARAIAYTQNLK----------G 683
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   939 KKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAkLTKEKKALQEAHQQALDDLQAEEDK-V 1017
Cdd:pfam18971  684 IKRELSDKLEKISKDLKDFSKSFDEFKNGKNKDFSKAEETLKALKGSVKDLG-INPEWISKVENLNAALNEFKNGKNKdF 762
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 124302198  1018 NTLTKAKVKLEQQVDDLEGSLEQEKKV-RMDLERAKRKLEGDLKLTQESIMDLEN-DKQQLDERLKK-KDF 1085
Cdd:pfam18971  763 SKVTQAKSDLENSVKDVIINQKVTDKVdNLNQAVSVAKAMGDFSRVEQVLADLKNfSKEQLAQQAQKnEDF 833
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
843-967 2.08e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 44.92  E-value: 2.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  843 AEREKEMASMKEEFTRLKEALEKSEARRKELEEKM--VSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVK 920
Cdd:COG1579    48 EAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLgnVRNNKEYEALQKEIESLKRRISDLEDEILELMERIEELEEELA 127
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 124302198  921 EMNERLEDEEEmnaELTAKKRKLEDECSELKRDIDDLELTLAKVEKE 967
Cdd:COG1579   128 ELEAELAELEA---ELEEKKAELDEELAELEAELEELEAEREELAAK 171
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
1258-1905 2.08e-04

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 46.58  E-value: 2.08e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1258 EHRSKAEETQRSVNDLTSQRAKLQTENGE--LSRQLDEKEALISQLTR-GKLTYTQQLEDLKRQLEEEVKAKNALAHALQ 1334
Cdd:TIGR01612  693 EDKAKLDDLKSKIDKEYDKIQNMETATVElhLSNIENKKNELLDIIVEiKKHIHGEINKDLNKILEDFKNKEKELSNKIN 772
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1335 SarhdcdllreqYEEETEAkaelqrvLSKANSEVAQWRTKY-ETDAIQRTEElEEAKkklaQRLQEAEEAVEAVNAKCSS 1413
Cdd:TIGR01612  773 D-----------YAKEKDE-------LNKYKSKISEIKNHYnDQINIDNIKD-EDAK----QNYDKSKEYIKTISIKEDE 829
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1414 LEKTKHRLQNEIEDLMVDVER----SNAAAAALDKKQRNFDKILAEWKQKYEESQSEL-ESSQKEARSLSTELfklKNAY 1488
Cdd:TIGR01612  830 IFKIINEMKFMKDDFLNKVDKfinfENNCKEKIDSEHEQFAELTNKIKAEISDDKLNDyEKKFNDSKSLINEI---NKSI 906
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1489 EESLEHLETFKREN------KNLQEEISD-------LTEQLGSSGKTIHELEKVRK----QLEAEKMELQSALEEA--EA 1549
Cdd:TIGR01612  907 EEEYQNINTLKKVDeyikicENTKESIEKfhnkqniLKEILNKNIDTIKESNLIEKsykdKFDNTLIDKINELDKAfkDA 986
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1550 SLEHEEGKILRAQLEFNQIKAEI----ERKLAEKDEEMEQAKRNHL-RVVDSLQTSLDAETRSRNEALRVKKKMEGD--- 1621
Cdd:TIGR01612  987 SLNDYEAKNNELIKYFNDLKANLgknkENMLYHQFDEKEKATNDIEqKIEDANKNIPNIEIAIHTSIYNIIDEIEKEigk 1066
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1622 ---------LNEMEIQLSHANRMaaEAQKQVKSLQSLLKDTQIQLDDAV-RANDDLK-------ENIAIVERRNNLLQAE 1684
Cdd:TIGR01612 1067 niellnkeiLEEAEINITNFNEI--KEKLKHYNFDDFGKEENIKYADEInKIKDDIKnldqkidHHIKALEEIKKKSENY 1144
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1685 LEELRAVVEQTER-SRKLAEQELIETSERVQllhsQN-TSLINQKKKMDADLSQLQTEVEE------AVQECRNAEEKAK 1756
Cdd:TIGR01612 1145 IDEIKAQINDLEDvADKAISNDDPEEIEKKI----ENiVTKIDKKKNIYDEIKKLLNEIAEiekdktSLEEVKGINLSYG 1220
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1757 KAItdAAMMAEELKKEQDTSAHlerMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAE----QKR 1832
Cdd:TIGR01612 1221 KNL--GKLFLEKIDEEKKKSEH---MIKAMEAYIEDLDEIKEKSPEIENEMGIEMDIKAEMETFNISHDDDKDhhiiSKK 1295
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1833 NAESVKGMRKSERRI--------------KEL-TYQTEEDRKN------LLRLQDLVDKLQL--------KVKAYKRQAE 1883
Cdd:TIGR01612 1296 HDENISDIREKSLKIiedfseesdindikKELqKNLLDAQKHNsdinlyLNEIANIYNILKLnkikkiidEVKEYTKEIE 1375
                          730       740
                   ....*....|....*....|..
gi 124302198  1884 EAEEQANTNLSKFRKVQHELDE 1905
Cdd:TIGR01612 1376 ENNKNIKDELDKSEKLIKKIKD 1397
Yuri_gagarin pfam15934
Yuri gagarin; The yuri gagarin protein found in Drosophila, it plays roles in spermatogenesis.
868-1022 2.12e-04

Yuri gagarin; The yuri gagarin protein found in Drosophila, it plays roles in spermatogenesis.


Pssm-ID: 318204 [Multi-domain]  Cd Length: 234  Bit Score: 44.95  E-value: 2.12e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   868 ARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQL---------------IKNKI--------QLEAKVKEMNE 924
Cdd:pfam15934   41 ENKNEQEQQLKEFTVQNQRLACQIDNLHETLKDRDHQIKQLqsmitgysdisennrLKEEIhdlkqkncVQARVVRKMGL 120
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   925 RLEDEEEMNAELTAKKRKL----EDECSELK---RDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLdeiiakltKEKK 997
Cdd:pfam15934  121 ELKGQEEQRVELCDKYESLlgsfEEQCQELKranRRVQSLQTRLSQVEKLQEELRTERKILREEVIAL--------KEKD 192
                          170       180
                   ....*....|....*....|....*....
gi 124302198   998 ALQEAHQQALDD----LQAEEDKVNTLTK 1022
Cdd:pfam15934  193 AKSNGRERALQDqlkcCQTEIEKSRTLIR 221
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
843-1113 2.30e-04

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 46.04  E-value: 2.30e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   843 AEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEM 922
Cdd:pfam07888   76 RELESRVAELKEELRQSREKHEELEEKYKELSASSEELSEEKDALLAQRAAHEARIRELEEDIKTLTQRVLERETELERM 155
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   923 NER-------LEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAK---L 992
Cdd:pfam07888  156 KERakkagaqRKEEEAERKQLQAKLQQTEEELRSLSKEFQELRNSLAQRDTQVLQLQDTITTLTQKLTTAHRKEAEneaL 235
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   993 TKEKKALQE---AHQQA-------LDDLQAEEDKVNT-LTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKL 1061
Cdd:pfam07888  236 LEELRSLQErlnASERKveglgeeLSSMAAQRDRTQAeLHQARLQAAQLTLQLADASLALREGRARWAQERETLQQSAEA 315
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 124302198  1062 TQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQ----ALGSQLQKKLKELQA 1113
Cdd:pfam07888  316 DKDRIEKLSAELQRLEERLQEERMEREKLEVELGREKdcnrVQLSESRRELQELKA 371
PRK10246 PRK10246
exonuclease subunit SbcC; Provisional
962-1703 2.35e-04

exonuclease subunit SbcC; Provisional


Pssm-ID: 182330 [Multi-domain]  Cd Length: 1047  Bit Score: 46.33  E-value: 2.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  962 AKVEKEK-HATENKVKNLTEE-MAGLDEIIAKLTKEKKAL---QEAHQQAL------DDLQAEEDKVNT-LTKAKVKLEQ 1029
Cdd:PRK10246  196 ARTELEKlQAQASGVALLTPEqVQSLTASLQVLTDEEKQLltaQQQQQQSLnwltrlDELQQEASRRQQaLQQALAAEEK 275
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1030 QVDDLegsleqekkVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDErlkkkdfelnaLNARIEDEQALgsqlqkklk 1109
Cdd:PRK10246  276 AQPQL---------AALSLAQPARQLRPHWERIQEQSAALAHTRQQIEE-----------VNTRLQSTMAL--------- 326
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1110 elQARIEELEEELEAERTARakveklRSDLSRELEEiSERL----EEAGGATSVQIEMNKKReAEFQKMRRDLEEATLQH 1185
Cdd:PRK10246  327 --RARIRHHAAKQSAELQAQ------QQSLNTWLAE-HDRFrqwnNELAGWRAQFSQQTSDR-EQLRQWQQQLTHAEQKL 396
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1186 EATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEE 1265
Cdd:PRK10246  397 NALPAITLTLTADEVAAALAQHAEQRPLRQRLVALHGQIVPQQKRLAQLQVAIQNVTQEQTQRNAALNEMRQRYKEKTQQ 476
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1266 TQR---------SVNDLTSQRAKLQTENGELSRQLDEKEAlISQLTRGKLTYTQQLEDlkrQLEEEVKaknALAHALQSA 1336
Cdd:PRK10246  477 LADvkticeqeaRIKDLEAQRAQLQAGQPCPLCGSTSHPA-VEAYQALEPGVNQSRLD---ALEKEVK---KLGEEGAAL 549
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1337 RHDCDLLREQYEEETEakaELQRVLSKANSEVAQWRTKYETDAIQRTEELEeakkkLAQRLQEAEEAVEAVNakcssLEK 1416
Cdd:PRK10246  550 RGQLDALTKQLQRDES---EAQSLRQEEQALTQQWQAVCASLNITLQPQDD-----IQPWLDAQEEHERQLR-----LLS 616
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1417 TKHRLQNEIedlmvdversnaaaAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELfklkNAYEESLEHLE 1496
Cdd:PRK10246  617 QRHELQGQI--------------AAHNQQIIQYQQQIEQRQQQLLTALAGYALTLPQEDEEASWL----ATRQQEAQSWQ 678
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1497 TFKRENKNLQEEISDLT---EQLGSSGKTIHELEKVR----KQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFnqik 1569
Cdd:PRK10246  679 QRQNELTALQNRIQQLTpllETLPQSDDLPHSEETVAldnwRQVHEQCLSLHSQLQTLQQQDVLEAQRLQKAQAQF---- 754
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1570 aeiERKLAEKDEEMEQAkrnhlrvvdSLQTSLDAETRSRNEALrvKKKMEGDLNEMEIQLSHANR-MAAEAQKQVKSLQS 1648
Cdd:PRK10246  755 ---DTALQASVFDDQQA---------FLAALLDEETLTQLEQL--KQNLENQRQQAQTLVTQTAQaLAQHQQHRPDGLDL 820
                         730       740       750       760       770
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 124302198 1649 LLKDTQIQLDDAVRAnDDLKENIAIV-ERRNNLLQAE--LEELRAVVEQTERSRKLAE 1703
Cdd:PRK10246  821 TVTVEQIQQELAQLA-QQLRENTTRQgEIRQQLKQDAdnRQQQQALMQQIAQATQQVE 877
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
1489-1628 2.38e-04

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 46.00  E-value: 2.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1489 EESLEHLeTFKRENKNLQEEISDLTEQ---LGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEF 1565
Cdd:COG2433   379 EEALEEL-IEKELPEEEPEAEREKEHEereLTEEEEEIRRLEEQVERLEAEVEELEAELEEKDERIERLERELSEARSEE 457
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 124302198 1566 NQiKAEIERKLAEKDEEmeqakrnhlrvVDSLQTSLDaETRSRNEALRVKKKMEGDLNEMEIQ 1628
Cdd:COG2433   458 RR-EIRKDREISRLDRE-----------IERLERELE-EERERIEELKRKLERLKELWKLEHS 507
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
1138-1850 2.45e-04

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 46.48  E-value: 2.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1138 DLSRELEEISER---LEEAGGATS--VQIEMNKKREAE-FQKMRRDLEEATLQHEATAAAlrkkhadsVAELGEQIDNLQ 1211
Cdd:COG3096   310 EMARELEELSAResdLEQDYQAASdhLNLVQTALRQQEkIERYQEDLEELTERLEEQEEV--------VEEAAEQLAEAE 381
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1212 RVKQKLEKEKSEFKLELDDVTSNME----------QIIKAKANLEKMCR-------TLEDQMNEHRSKAEETQRSVNDL- 1273
Cdd:COG3096   382 ARLEAAEEEVDSLKSQLADYQQALDvqqtraiqyqQAVQALEKARALCGlpdltpeNAEDYLAAFRAKEQQATEEVLELe 461
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1274 ----TSQRAKLQTENG---------------------ELSRQLDEKEALISQLTrgklTYTQQLEDLKRQLEEEVKAK-- 1326
Cdd:COG3096   462 qklsVADAARRQFEKAyelvckiageversqawqtarELLRRYRSQQALAQRLQ----QLRAQLAELEQRLRQQQNAErl 537
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1327 -NALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRtkyetdaiQRTEELEEAKKKLAQR---LQEAEE 1402
Cdd:COG3096   538 lEEFCQRIGQQLDAAEELEELLAELEAQLEELEEQAAEAVEQRSELR--------QQLEQLRARIKELAARapaWLAAQD 609
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1403 AVEAVNAKC-----SSLEKTKHR---LQNEIEdlmVDVERSNAAAA--ALDKKQRN-------FDKILAEWKQKYeesqs 1465
Cdd:COG3096   610 ALERLREQSgealaDSQEVTAAMqqlLERERE---ATVERDELAARkqALESQIERlsqpggaEDPRLLALAERL----- 681
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1466 elessqkeARSLSTELFK---LKNA-YEESL----------EHLETFKRENKNLQEEISDL-----TEQLGS-SGKTIHE 1525
Cdd:COG3096   682 --------GGVLLSEIYDdvtLEDApYFSALygparhaivvPDLSAVKEQLAGLEDCPEDLyliegDPDSFDdSVFDAEE 753
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1526 LEK----------VR----------------KQLEAEKMELQsALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEK 1579
Cdd:COG3096   754 LEDavvvklsdrqWRysrfpevplfgraareKRLEELRAERD-ELAEQYAKASFDVQKLQRLHQAFSQFVGGHLAVAFAP 832
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1580 DEEME-QAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMeiqLSHANRMAAEaqkqvkSLQSLLKDTQIQLD 1658
Cdd:COG3096   833 DPEAElAALRQRRSELERELAQHRAQEQQLRQQLDQLKEQLQLLNKL---LPQANLLADE------TLADRLEELREELD 903
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1659 DAVRANDDLKEN---IAIVERRNNLLQ---AELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDA 1732
Cdd:COG3096   904 AAQEAQAFIQQHgkaLAQLEPLVAVLQsdpEQFEQLQADYLQAKEQQRRLKQQIFALSEVVQRRPHFSYEDAVGLLGENS 983
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1733 DLS-QLQTEVEEAVQECRNAEEKAKKA---ITDAAMMAEELKKEQDTSAhleRMKKNMEQTIKDLQHRLD-EAEQIAlkg 1807
Cdd:COG3096   984 DLNeKLRARLEQAEEARREAREQLRQAqaqYSQYNQVLASLKSSRDAKQ---QTLQELEQELEELGVQADaEAEERA--- 1057
                         810       820       830       840
                  ....*....|....*....|....*....|....*....|...
gi 124302198 1808 gkkqlqklEARVRELENELEAEQKRNAESVKGMRKSERRIKEL 1850
Cdd:COG3096  1058 --------RIRRDELHEELSQNRSRRSQLEKQLTRCEAEMDSL 1092
PRK12704 PRK12704
phosphodiesterase; Provisional
1325-1459 2.48e-04

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 45.92  E-value: 2.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1325 AKNALAHALQSARHDCDLLREqyEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAV 1404
Cdd:PRK12704   25 RKKIAEAKIKEAEEEAKRILE--EAKKEAEAIKKEALLEAKEEIHKLRNEFEKELRERRNELQKLEKRLLQKEENLDRKL 102
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 124302198 1405 EAVNAKCSSLEKTKHRLQNEIEDlmvdversnaaaaaLDKKQRNFDKILAEWKQK 1459
Cdd:PRK12704  103 ELLEKREEELEKKEKELEQKQQE--------------LEKKEEELEELIEEQLQE 143
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
853-1406 2.68e-04

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 46.20  E-value: 2.68e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   853 KEEFTRLKEALEKSEARRKELEEKM---VSLLQE-KNDLQLQVQAEQDNLADAEERCDQLIKNK--IQLEAKVKEMNERL 926
Cdd:TIGR01612 1103 KEENIKYADEINKIKDDIKNLDQKIdhhIKALEEiKKKSENYIDEIKAQINDLEDVADKAISNDdpEEIEKKIENIVTKI 1182
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   927 EDEEEMNAELtakkRKLEDECSELKRDIDDLE---------------LTLAKVEKEKHATENKVKNLTEEMAGLDEIiak 991
Cdd:TIGR01612 1183 DKKKNIYDEI----KKLLNEIAEIEKDKTSLEevkginlsygknlgkLFLEKIDEEKKKSEHMIKAMEAYIEDLDEI--- 1255
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   992 ltKEKKALQEAHQQALDDLQAEEDKVNT--------LTKAKVKLEQQVDDLEGSLE--QEKKVRMDLERAKRKLEGDLKL 1061
Cdd:TIGR01612 1256 --KEKSPEIENEMGIEMDIKAEMETFNIshdddkdhHIISKKHDENISDIREKSLKiiEDFSEESDINDIKKELQKNLLD 1333
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1062 TQE----------------SIMDLENDKQQLDErLKKKDFELNALNARIEDEQALGSQLQKK------LKELQARIEELE 1119
Cdd:TIGR01612 1334 AQKhnsdinlylneianiyNILKLNKIKKIIDE-VKEYTKEIEENNKNIKDELDKSEKLIKKikddinLEECKSKIESTL 1412
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1120 EELEAERTARaKVEKLRSDLSRELEEISERLEEAGGATS------VQIEMNKKREAEFQKMRRDleEATLQHEATAAALr 1193
Cdd:TIGR01612 1413 DDKDIDECIK-KIKELKNHILSEESNIDTYFKNADENNEnvlllfKNIEMADNKSQHILKIKKD--NATNDHDFNINEL- 1488
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1194 KKHADSVAELGEQIDnlqRVKQKLEKEKSEFKLELDDVTSNMEQ---------IIKAKANLEKMCRTLEDQMNEHRSKAE 1264
Cdd:TIGR01612 1489 KEHIDKSKGCKDEAD---KNAKAIEKNKELFEQYKKDVTELLNKysalaiknkFAKTKKDSEIIIKEIKDAHKKFILEAE 1565
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1265 ETQRSVNDLTSQRAKLQTENGELSRQ-------------LDEKEALISQLTRGKLTYTQQLEDLKRQL--------EEEV 1323
Cdd:TIGR01612 1566 KSEQKIKEIKKEKFRIEDDAAKNDKSnkaaidiqlslenFENKFLKISDIKKKINDCLKETESIEKKIssfsidsqDTEL 1645
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1324 KAKNALAHALQSArhdCDLLREQYEEETEAKAELQRVLSKANS---EVAQWRTKYETDAIQRTEELEEAKKklaQRLQEA 1400
Cdd:TIGR01612 1646 KENGDNLNSLQEF---LESLKDQKKNIEDKKKELDELDSEIEKieiDVDQHKKNYEIGIIEKIKEIAIANK---EEIESI 1719

                   ....*.
gi 124302198  1401 EEAVEA 1406
Cdd:TIGR01612 1720 KELIEP 1725
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
1253-1446 2.78e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 45.59  E-value: 2.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1253 EDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHA 1332
Cdd:COG3883    15 DPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERARA 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1333 LQSARHDCDLL---------------REQYEEETEAKAELQRVLSKANSEVAQwrtkYETDAIQRTEELEEAKKKLAQRL 1397
Cdd:COG3883    95 LYRSGGSVSYLdvllgsesfsdfldrLSALSKIADADADLLEELKADKAELEA----KKAELEAKLAELEALKAELEAAK 170
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 124302198 1398 QEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQ 1446
Cdd:COG3883   171 AELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAA 219
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1669-1917 2.81e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 45.53  E-value: 2.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1669 ENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQEC 1748
Cdd:COG4942    20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAEL 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1749 RNAEEKAKKAITDAAMMAE----ELKKEQDTSAHLERMKKNMEQTIKDLQHRLDE--AEQIALKGGKKQLQKLEARVREL 1822
Cdd:COG4942   100 EAQKEELAELLRALYRLGRqpplALLLSPEDFLDAVRRLQYLKYLAPARREQAEElrADLAELAALRAELEAERAELEAL 179
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1823 ENELEAEQKRnaesvkgmrkserrikeltyqteedrknllrLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHE 1902
Cdd:COG4942   180 LAELEEERAA-------------------------------LEALKAERQKLLARLEKELAELAAELAELQQEAEELEAL 228
                         250
                  ....*....|....*
gi 124302198 1903 LDEAEERADIAESQV 1917
Cdd:COG4942   229 IARLEAEAAAAAERT 243
PRK11637 PRK11637
AmiB activator; Provisional
885-1097 3.98e-04

AmiB activator; Provisional


Pssm-ID: 236942 [Multi-domain]  Cd Length: 428  Bit Score: 45.07  E-value: 3.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  885 NDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKemnerleDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKV 964
Cdd:PRK11637   43 SDNRDQLKSIQQDIAAKEKSVRQQQQQRASLLAQLK-------KQEEAISQASRKLRETQNTLNQLNKQIDELNASIAKL 115
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  965 EKEKHATEnkvKNLTEEM---------AGLDEIIAKLTKEKKALQEAHQQALDdlQAEEDKVNTLTKAKVKLEQQVDDLE 1035
Cdd:PRK11637  116 EQQQAAQE---RLLAAQLdaafrqgehTGLQLILSGEESQRGERILAYFGYLN--QARQETIAELKQTREELAAQKAELE 190
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 124302198 1036 GSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLEN----DKQQLDErLKKKDFELNALNARIEDE 1097
Cdd:PRK11637  191 EKQSQQKTLLYEQQAQQQKLEQARNERKKTLTGLESslqkDQQQLSE-LRANESRLRDSIARAERE 255
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
1673-1811 4.03e-04

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 45.59  E-value: 4.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1673 IVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDAdlsQLQTEVEEAVQECRNAE 1752
Cdd:PRK00409  503 IIEEAKKLIGEDKEKLNELIASLEELERELEQKAEEAEALLKEAEKLKEELEEKKEKLQE---EEDKLLEEAEKEAQQAI 579
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 124302198 1753 EKAKKAITDAAMMAEELKKEQDTSAHLermkKNMEQTIKDLQHRLDEAEQIALKGGKKQ 1811
Cdd:PRK00409  580 KEAKKEADEIIKELRQLQKGGYASVKA----HELIEARKRLNKANEKKEKKKKKQKEKQ 634
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1203-1447 4.28e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 45.39  E-value: 4.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1203 LGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEqiikAKANLEKMcRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQT 1282
Cdd:COG3206   180 LEEQLPELRKELEEAEAALEEFRQKNGLVDLSEE----AKLLLQQL-SELESQLAEARAELAEAEARLAALRAQLGSGPD 254
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1283 ENGELSRQldekeALISQLTrgkltytQQLEDLKRQLEEEvkaknalahalqSARhdcdlLREQYEEETEAKAELQRVLS 1362
Cdd:COG3206   255 ALPELLQS-----PVIQQLR-------AQLAELEAELAEL------------SAR-----YTPNHPDVIALRAQIAALRA 305
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1363 KANSEVAQWRTKYETDAiqrtEELEEAKKKLAQRLQEAEEAVEAVNAKcsslektkhrlQNEIEDLMVDVERSNAAAAAL 1442
Cdd:COG3206   306 QLQQEAQRILASLEAEL----EALQAREASLQAQLAQLEARLAELPEL-----------EAELRRLEREVEVARELYESL 370

                  ....*
gi 124302198 1443 DKKQR 1447
Cdd:COG3206   371 LQRLE 375
PRK12704 PRK12704
phosphodiesterase; Provisional
898-1013 4.29e-04

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 45.15  E-value: 4.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  898 LADAEERCDQLIKN----------KIQLEAKVKEMNERLEDEEE---MNAELTAKKRKLEDECSELKRDIDDLELTLAKV 964
Cdd:PRK12704   33 IKEAEEEAKRILEEakkeaeaikkEALLEAKEEIHKLRNEFEKElreRRNELQKLEKRLLQKEENLDRKLELLEKREEEL 112
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 124302198  965 EKEKHATENKVKNLTEEMAGLDEIIAK----------LTKEkkalqEAHQQALDDLQAE 1013
Cdd:PRK12704  113 EKKEKELEQKQQELEKKEEELEELIEEqlqelerisgLTAE-----EAKEILLEKVEEE 166
PRK12704 PRK12704
phosphodiesterase; Provisional
834-998 4.83e-04

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 44.77  E-value: 4.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  834 FKIKPLLKSAEREKEMAS------MKEEFTRLKEALEK-SEARRKELEEKMVSLLQEKNDLqlqvqaeqdnladaEERCD 906
Cdd:PRK12704   38 EEAKRILEEAKKEAEAIKkealleAKEEIHKLRNEFEKeLRERRNELQKLEKRLLQKEENL--------------DRKLE 103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  907 QLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDE---CSELKRDiDDLELTLAKVEKE-KHATENKVKNLTEEm 982
Cdd:PRK12704  104 LLEKREEELEKKEKELEQKQQELEKKEEELEELIEEQLQElerISGLTAE-EAKEILLEKVEEEaRHEAAVLIKEIEEE- 181
                         170
                  ....*....|....*.
gi 124302198  983 agldeiiAKLTKEKKA 998
Cdd:PRK12704  182 -------AKEEADKKA 190
46 PHA02562
endonuclease subunit; Provisional
1687-1871 4.97e-04

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 45.01  E-value: 4.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1687 ELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKK---AITDAA 1763
Cdd:PHA02562  189 KIDHIQQQIKTYNKNIEEQRKKNGENIARKQNKYDELVEEAKTIKAEIEELTDELLNLVMDIEDPSAALNKlntAAAKIK 268
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1764 MMAEELKKE--------------QDTSAHLERMKKNMEQtIKDLQHRLDEAE--QIALKGGKKQLQKLEARVRELENELE 1827
Cdd:PHA02562  269 SKIEQFQKVikmyekggvcptctQQISEGPDRITKIKDK-LKELQHSLEKLDtaIDELEEIMDEFNEQSKKLLELKNKIS 347
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 124302198 1828 AEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKL 1871
Cdd:PHA02562  348 TNKQSLITLVDKAKKVKAAIEELQAEFVDNAEELAKLQDELDKI 391
PTZ00440 PTZ00440
reticulocyte binding protein 2-like protein; Provisional
852-1576 5.21e-04

reticulocyte binding protein 2-like protein; Provisional


Pssm-ID: 240419 [Multi-domain]  Cd Length: 2722  Bit Score: 45.21  E-value: 5.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  852 MKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMN-------- 923
Cdd:PTZ00440  726 YTIKYNDLKSSIEEYKEEEEKLEVYKHQIINRKNEFILHLYENDKDLPDGKNTYEEFLQYKDTILNKENKISndinilke 805
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  924 ----------------ERLEDEEEMNAE-------------LTAKKRKLEDECSELKRDID----DLEL------TLAKV 964
Cdd:PTZ00440  806 nkknnqdllnsyniliQKLEAHTEKNDEelkqllqkfptedENLNLKELEKEFNENNQIVDniikDIENmnkninIIKTL 885
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  965 EKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQ-------EAHQQALDDLQAEEDKVNT------LTKAKVKLEQQV 1031
Cdd:PTZ00440  886 NIAINRSNSNKQLVEHLLNNKIDLKNKLEQHMKIINtdniiqkNEKLNLLNNLNKEKEKIEKqlsdtkINNLKMQIEKTL 965
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1032 D-----------DLEGSLEQEKKVRMDLERAKRKLEG---DLKLTQESIMDLENDKQQ-----LDERLKKKDfelNALNA 1092
Cdd:PTZ00440  966 EyydkskeningNDGTHLEKLDKEKDEWEHFKSEIDKlnvNYNILNKKIDDLIKKQHDdiielIDKLIKEKG---KEIEE 1042
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1093 RIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEE-----AGGATSVQIEMNKKR 1167
Cdd:PTZ00440 1043 KVDQYISLLEKMKTKLSSFHFNIDIKKYKNPKIKEEIKLLEEKVEALLKKIDENKNKLIEiknksHEHVVNADKEKNKQT 1122
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1168 EAeFQKMRRDLEEATLQHEATAAALRKKH-----ADSVAELGEQIDNL--QRVKQKLEKEKSEFKLELDDVTSNMEQIIK 1240
Cdd:PTZ00440 1123 EH-YNKKKKSLEKIYKQMEKTLKELENMNleditLNEVNEIEIEYERIliDHIVEQINNEAKKSKTIMEEIESYKKDIDQ 1201
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1241 AKANL--EKMCRTLEDQMNEHRSKAEETQRSVNDLTsQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQ 1318
Cdd:PTZ00440 1202 VKKNMskERNDHLTTFEYNAYYDKATASYENIEELT-TEAKGLKGEANRSTNVDELKEIKLQVFSYLQQVIKENNKMENA 1280
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1319 LeEEVKAKNALAHALQSARHDCDLLREQYEEET---EAKAELQ---RVLSKANSEVAQWRT-KYETDAIQRTEELEEAKK 1391
Cdd:PTZ00440 1281 L-HEIKNMYEFLISIDSEKILKEILNSTKKAEEfsnDAKKELEktdNLIKQVEAKIEQAKEhKNKIYGSLEDKQIDDEIK 1359
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1392 KLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEdlmvDVERSNAAAAALDKKQRNFDKILAEWK-QKYEESQSELESS 1470
Cdd:PTZ00440 1360 KIEQIKEEISNKRKEINKYLSNIKSNKEKCDLHVR----NASRGKDKIDFLNKHEAIEPSNSKEVNiIKITDNINKCKQY 1435
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1471 QKEARSLSTELFKLKNA---YEESLEH-------------LETFKRENKNLQEEI----SDLTEQLGSSGKTIHELEKVR 1530
Cdd:PTZ00440 1436 SNEAMETENKADENNDSiikYEKEITNilnnssilgkktkLEKKKKEATNIMDDIngehSIIKTKLTKSSEKLNQLNEQP 1515
                         810       820       830       840
                  ....*....|....*....|....*....|....*....|....*.
gi 124302198 1531 KQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKL 1576
Cdd:PTZ00440 1516 NIKREGDVLNNDKSTIAYETIQYNLGRVKHNLLNILNIKDEIETIL 1561
PRK05035 PRK05035
electron transport complex protein RnfC; Provisional
1141-1410 5.37e-04

electron transport complex protein RnfC; Provisional


Pssm-ID: 235334 [Multi-domain]  Cd Length: 695  Bit Score: 44.94  E-value: 5.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1141 RELEEISERLEEAggatsvqiemnKKR-EAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELgeqidnLQRVKQKLEK 1219
Cdd:PRK05035  439 RAIEQEKKKAEEA-----------KARfEARQARLEREKAAREARHKKAAEARAAKDKDAVAAA------LARVKAKKAA 501
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1220 EKSEFKLELDDVTSNMEQIIKAKAnlekmcrtledqmnehrSKAEETQRSVNDLTSQRAklqtengelsrqlDEKEALIS 1299
Cdd:PRK05035  502 ATQPIVIKAGARPDNSAVIAAREA-----------------RKAQARARQAEKQAAAAA-------------DPKKAAVA 551
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1300 Q-LTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALqsARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETD 1378
Cdd:PRK05035  552 AaIARAKAKKAAQQAANAEAEEEVDPKKAAVAAAI--ARAKAKKAAQQAASAEPEEQVAEVDPKKAAVAAAIARAKAKKA 629
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 124302198 1379 AIQRTEELEE---------------AKKKLAQRLQEAEEAVEAVNAK 1410
Cdd:PRK05035  630 EQQANAEPEEpvdprkaavaaaiarAKARKAAQQQANAEPEEAEDPK 676
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
960-1191 5.50e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 44.44  E-value: 5.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  960 TLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLE 1039
Cdd:COG3883    10 TPAFADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELG 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1040 qekkvrmdlERAKRKLEG-------DLKLTQESIMDL-----------ENDKQQLDERLKKKDfELNALNARIEDEQAlg 1101
Cdd:COG3883    90 ---------ERARALYRSggsvsylDVLLGSESFSDFldrlsalskiaDADADLLEELKADKA-ELEAKKAELEAKLA-- 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1102 sQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEA 1181
Cdd:COG3883   158 -ELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAA 236
                         250
                  ....*....|
gi 124302198 1182 TLQHEATAAA 1191
Cdd:COG3883   237 AAAAAAAASA 246
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
1024-1573 5.71e-04

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 44.73  E-value: 5.71e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1024 KVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDfelNALNARIEDEQALGSQ 1103
Cdd:pfam05557    8 KARLSQLQNEKKQMELEHKRARIELEKKASALKRQLDRESDRNQELQKRIRLLEKREAEAE---EALREQAELNRLKKKY 84
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1104 LQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSvQIEMNKKREAEFQKMRRDLEEAtl 1183
Cdd:pfam05557   85 LEALNKKLNEKESQLADAREVISCLKNELSELRRQIQRAELELQSTNSELEELQE-RLDLLKAKASEAEQLRQNLEKQ-- 161
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1184 QHEATAAALRKKhadsvaELGEQIDNLQRVKQKLEKEKSEFkLELDDVTSNMEQIIKAKANLEKMCRT---LEDQMNEHR 1260
Cdd:pfam05557  162 QSSLAEAEQRIK------ELEFEIQSQEQDSEIVKNSKSEL-ARIPELEKELERLREHNKHLNENIENkllLKEEVEDLK 234
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1261 SKAEETQRSVNDLtsqrAKLQTENGELSRQLDEKEAL-----------------ISQLTRGKLTYTQQLEDLKRQLEEEV 1323
Cdd:pfam05557  235 RKLEREEKYREEA----ATLELEKEKLEQELQSWVKLaqdtglnlrspedlsrrIEQLQQREIVLKEENSSLTSSARQLE 310
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1324 KAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEelEEAKKKLAQRLQEAEEA 1403
Cdd:pfam05557  311 KARRELEQELAQYLKKIEDLNKKLKRHKALVRRLQRRVLLLTKERDGYRAILESYDKELTM--SNYSPQLLERIEEAEDM 388
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1404 VEAVNAKCSSLEktkHRLQNEIEDLMVDVERSNAAAAALDKKQRNfdkilaewkqkyeesqseleSSQKEARSLSTELFK 1483
Cdd:pfam05557  389 TQKMQAHNEEME---AQLSVAEEELGGYKQQAQTLERELQALRQQ--------------------ESLADPSYSKEEVDS 445
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1484 LKNAYEESLEHLETFKRENKNLQEEISDLTEQLG---SSGKTIH---------------ELEKVRKQLEAEKMELQSALE 1545
Cdd:pfam05557  446 LRRKLETLELERQRLREQKNELEMELERRCLQGDydpKKTKVLHlsmnpaaeayqqrknQLEKLQAEIERLKRLLKKLED 525
                          570       580
                   ....*....|....*....|....*...
gi 124302198  1546 EAEASLEHEEGKILRAQLEFNQIKAEIE 1573
Cdd:pfam05557  526 DLEQVLRLPETTSTMNFKEVLDLRKELE 553
Tropomyosin pfam00261
Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 ...
1628-1833 7.35e-04

Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 parallel helices containing 2 sets of 7 alternating actin binding sites. The protein is best known for its role in regulating the interaction between actin and myosin in muscle contraction, but is also involved in the organization and dynamics of the cytoskeleton in non-muscle cells. There are multiple cell-specific isoforms, expressed by alternative promoters and alternative RNA processing of at least four genes. Muscle isoforms of tropomyosin are characterized by having 284 amino acid residues and a highly conserved N-terminal region, whereas non-muscle forms are generally smaller and are heterogeneous in their N-terminal region.


Pssm-ID: 459736 [Multi-domain]  Cd Length: 235  Bit Score: 43.09  E-value: 7.35e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1628 QLSHANRMAAEAQKQVKSLQSLLKDTQIQLDdavRANDDLKENiaiverrnnllQAELEELRAVVEQTERSRKLAEQELI 1707
Cdd:pfam00261   23 KLEEAEKRAEKAEAEVAALNRRIQLLEEELE---RTEERLAEA-----------LEKLEEAEKAADESERGRKVLENRAL 88
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1708 ETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLE------- 1780
Cdd:pfam00261   89 KDEEKMEILEAQLKEAKEIAEEADRKYEEVARKLVVVEGDLERAEERAELAESKIVELEEELKVVGNNLKSLEaseekas 168
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 124302198  1781 RMKKNMEQTIKDLQHRLDEAEQIALKGgKKQLQKLEARVRELENELEAEQKRN 1833
Cdd:pfam00261  169 EREDKYEEQIRFLTEKLKEAETRAEFA-ERSVQKLEKEVDRLEDELEAEKEKY 220
PTZ00121 PTZ00121
MAEBL; Provisional
800-1064 7.60e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 44.75  E-value: 7.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  800 EYKKLLERRDSLLVIQWNIRAFMGVKNWPWMKLYFKIKPLLKSAEREKEMASMKeeftrlKEALEKSEARRKELEEKMVS 879
Cdd:PTZ00121 1568 EAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIK------AEELKKAEEEKKKVEQLKKK 1641
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  880 LLQEKNDLQLQVQAEQDNLADAEErcdqlIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRdiddlel 959
Cdd:PTZ00121 1642 EAEEKKKAEELKKAEEENKIKAAE-----EAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKK------- 1709
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  960 tlaKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQalddlQAEEDKVNTLTKAKVKLEQQVDDL----- 1034
Cdd:PTZ00121 1710 ---KEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKD-----EEEKKKIAHLKKEEEKKAEEIRKEkeavi 1781
                         250       260       270
                  ....*....|....*....|....*....|.
gi 124302198 1035 -EGSLEQEKKVRMDLERAKRKLEGDLKLTQE 1064
Cdd:PTZ00121 1782 eEELDEEDEKRRMEVDKKIKDIFDNFANIIE 1812
Filament pfam00038
Intermediate filament protein;
873-1151 7.78e-04

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 43.76  E-value: 7.78e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   873 LEEKMVSLLQEKNDLQLQVQAEQDN--------LADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLE 944
Cdd:pfam00038   23 LEQQNKLLETKISELRQKKGAEPSRlyslyekeIEDLRRQLDTLTVERARLQLELDNLRLAAEDFRQKYEDELNLRTSAE 102
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   945 DECSELKRDIDdlELTLAKVEkekhaTENKVKNLTEEMAGLDEIiakLTKEKKALQEAHQQalDDLQAEEDKVNT--LTK 1022
Cdd:pfam00038  103 NDLVGLRKDLD--EATLARVD-----LEAKIESLKEELAFLKKN---HEEEVRELQAQVSD--TQVNVEMDAARKldLTS 170
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1023 AKVKLEQQVDdlegslEQEKKVRMDLERA-KRKLEgdlKLTQESIMDLEnDKQQLDERLKKKDFELNALNARIEDEQALG 1101
Cdd:pfam00038  171 ALAEIRAQYE------EIAAKNREEAEEWyQSKLE---ELQQAAARNGD-ALRSAKEEITELRRTIQSLEIELQSLKKQK 240
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|
gi 124302198  1102 SQLQKKLKELQARIEEleeeleaertARAKVEKLRSDLSRELEEISERLE 1151
Cdd:pfam00038  241 ASLERQLAETEERYEL----------QLADYQELISELEAELQETRQEMA 280
PLN02939 PLN02939
transferase, transferring glycosyl groups
1572-1926 8.27e-04

transferase, transferring glycosyl groups


Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 44.51  E-value: 8.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1572 IERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEAlrvkkKMEGDLNEMEIQLSHANRMAAEAQK---QVKSLQS 1648
Cdd:PLN02939   61 SNSKLQSNTDENGQLENTSLRTVMELPQKSTSSDDDHNRA-----SMQRDEAIAAIDNEQQTNSKDGEQLsdfQLEDLVG 135
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1649 LLKDTQ---IQLDDA-VRANDDLKEniaiVERRNNLLQAELEELRAVVEQTERSRKLAEQELIetseRVQLLHSQntsLI 1724
Cdd:PLN02939  136 MIQNAEkniLLLNQArLQALEDLEK----ILTEKEALQGKINILEMRLSETDARIKLAAQEKI----HVEILEEQ---LE 204
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1725 NQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTS---AHLERMKKNMEQTIKDLQHRLDEAE 1801
Cdd:PLN02939  205 KLRNELLIRGATEGLCVHSLSKELDVLKEENMLLKDDIQFLKAELIEVAETEervFKLEKERSLLDASLRELESKFIVAQ 284
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1802 QIALKGGKKQLQKLEARVRELENELEAEQKRNAESV---KGMRKSERRIKELTYQTEEDRKNLLRLQdLVDKLQLKVKAY 1878
Cdd:PLN02939  285 EDVSKLSPLQYDCWWEKVENLQDLLDRATNQVEKAAlvlDQNQDLRDKVDKLEASLKEANVSKFSSY-KVELLQQKLKLL 363
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 124302198 1879 KRQAEEAEEQANTnlskfrKVQHELDEAEERADIAESQVNKLRAKSRD 1926
Cdd:PLN02939  364 EERLQASDHEIHS------YIQLYQESIKEFQDTLSKLKEESKKRSLE 405
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
850-1173 8.63e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 43.74  E-value: 8.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  850 ASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDE 929
Cdd:COG4372    27 AALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESL 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  930 EEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAH-QQALD 1008
Cdd:COG4372   107 QEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAEaEQALD 186
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1009 DLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELN 1088
Cdd:COG4372   187 ELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKEIEELELA 266
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1089 ALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKRE 1168
Cdd:COG4372   267 ILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALLELAKKLELALAILLAELADLLQLL 346

                  ....*
gi 124302198 1169 AEFQK 1173
Cdd:COG4372   347 LVGLL 351
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
1475-1910 1.04e-03

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 44.19  E-value: 1.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1475 RSLSTELFKLKNAYEESLEHLEtfkrenKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHE 1554
Cdd:TIGR00618  179 TQLALMEFAKKKSLHGKAELLT------LRSQLLTLCTPCMPDTYHERKQVLEKELKHLREALQQTQQSHAYLTQKREAQ 252
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1555 EGKiLRAQLEFNQIKAEIERKLA-EKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEiQLSHAN 1633
Cdd:TIGR00618  253 EEQ-LKKQQLLKQLRARIEELRAqEAVLEETQERINRARKAAPLAAHIKAVTQIEQQAQRIHTELQSKMRSRA-KLLMKR 330
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1634 RMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQ----------AELEELRAVVEQTERSRKLAE 1703
Cdd:TIGR00618  331 AAHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSIREISCQQHTLTQhihtlqqqktTLTQKLQSLCKELDILQREQA 410
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1704 QELIETSE----RVQLLHSQNTSLINQKKKMD-----ADLSQLQTEVEEAVQECRNA-EEKAKKAITDAAMMAEELKKEQ 1773
Cdd:TIGR00618  411 TIDTRTSAfrdlQGQLAHAKKQQELQQRYAELcaaaiTCTAQCEKLEKIHLQESAQSlKEREQQLQTKEQIHLQETRKKA 490
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1774 DTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGG-----------KKQLQKLEARVRELENELEAEQKRNAESVKGMRK 1842
Cdd:TIGR00618  491 VVLARLLELQEEPCPLCGSCIHPNPARQDIDNPGPltrrmqrgeqtYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQ 570
                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 124302198  1843 SERRIKELTYQTEEDRKNLL----RLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERA 1910
Cdd:TIGR00618  571 SFSILTQCDNRSKEDIPNLQnitvRLQDLTEKLSEAEDMLACEQHALLRKLQPEQDLQDVRLHLQQCSQELA 642
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
1622-1763 1.10e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 42.60  E-value: 1.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1622 LNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQA---------ELEELRAVV 1692
Cdd:COG1579    19 LDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEqlgnvrnnkEYEALQKEI 98
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 124302198 1693 EQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAA 1763
Cdd:COG1579    99 ESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAEREELA 169
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
1766-1917 1.12e-03

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 44.08  E-value: 1.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1766 AEELKKEQDTSAHLERMKKNMEQTIKDLQhrldeaeqialkggkKQLQKLEARVRELENELEAEQKRNAES---VKGMRK 1842
Cdd:COG2433   391 PEEEPEAEREKEHEERELTEEEEEIRRLE---------------EQVERLEAEVEELEAELEEKDERIERLereLSEARS 455
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1843 SERR-------IKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRqAEEAEEQANT----NLSKFRKvqHELDEAEERAD 1911
Cdd:COG2433   456 EERReirkdreISRLDREIERLERELEEERERIEELKRKLERLKE-LWKLEHSGELvpvkVVEKFTK--EAIRRLEEEYG 532

                  ....*.
gi 124302198 1912 IAESQV 1917
Cdd:COG2433   533 LKEGDV 538
PRK09039 PRK09039
peptidoglycan -binding protein;
1076-1238 1.22e-03

peptidoglycan -binding protein;


Pssm-ID: 181619 [Multi-domain]  Cd Length: 343  Bit Score: 43.42  E-value: 1.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1076 LDERLKKKDFELNALNARIED-------EQALGSQLQKKLKELQARIEELEEEleaertaRAKVEKLRSDLSRELEEISE 1148
Cdd:PRK09039   44 LSREISGKDSALDRLNSQIAEladllslERQGNQDLQDSVANLRASLSAAEAE-------RSRLQALLAELAGAGAAAEG 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1149 RLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAAL---RKKHADS---VAELGEQIDN--LQRVKQkLEKE 1220
Cdd:PRK09039  117 RAGELAQELDSEKQVSARALAQVELLNQQIAALRRQLAALEAALdasEKRDRESqakIADLGRRLNValAQRVQE-LNRY 195
                         170
                  ....*....|....*...
gi 124302198 1221 KSEFKLELDDVTSNMEQI 1238
Cdd:PRK09039  196 RSEFFGRLREILGDREGI 213
PRK15374 PRK15374
type III secretion system needle tip complex protein SipB;
914-1115 1.27e-03

type III secretion system needle tip complex protein SipB;


Pssm-ID: 185272 [Multi-domain]  Cd Length: 593  Bit Score: 43.80  E-value: 1.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  914 QLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLT 993
Cdd:PRK15374  103 QLESRLAVWQAMIESQKEMGIQVSKEFQTALGEAQEATDLYEASIKKTDTAKSVYDAAEKKLTQAQNKLQSLDPADPGYA 182
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  994 KEKKALQEAHQQALDDLQAEEDK----VNTLTKAKVKLEQQvDDLEGSLEQEKKVRMDLERAK---RKLEGDLKLTQESI 1066
Cdd:PRK15374  183 QAEAAVEQAGKEATEAKEALDKAtdatVKAGTDAKAKAEKA-DNILTKFQGTANAASQNQVSQgeqDNLSNVARLTMLMA 261
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 124302198 1067 MDLENDKQQLDERLKKkdfELNALNARIEDEQAlgsQLQKKLKELQARI 1115
Cdd:PRK15374  262 MFIEIVGKNTEESLQN---DLALFNALQEGRQA---EMEKKSAEFQEET 304
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
1578-1922 1.40e-03

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 43.35  E-value: 1.40e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1578 EKDEEMEQAKRNHLRVVDS---LQTSLDAETRSRNEALR----VKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLL 1650
Cdd:pfam07888   10 EEESHGEEGGTDMLLVVPRaelLQNRLEECLQERAELLQaqeaANRQREKEKERYKRDREQWERQRRELESRVAELKEEL 89
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1651 KDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKM 1730
Cdd:pfam07888   90 RQSREKHEELEEKYKELSASSEELSEEKDALLAQRAAHEARIRELEEDIKTLTQRVLERETELERMKERAKKAGAQRKEE 169
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1731 DADLSQLQTEVEEAVQECRNaeekakkaitdaamMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQ--IALKGG 1808
Cdd:pfam07888  170 EAERKQLQAKLQQTEEELRS--------------LSKEFQELRNSLAQRDTQVLQLQDTITTLTQKLTTAHRkeAENEAL 235
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1809 KKQLQKLEARVRELENELEAeQKRNAESVKGMRksERRIKELTYQTEEDRKNLLRLQDLvdKLQLKVKAYKRQAEEAEEQ 1888
Cdd:pfam07888  236 LEELRSLQERLNASERKVEG-LGEELSSMAAQR--DRTQAELHQARLQAAQLTLQLADA--SLALREGRARWAQERETLQ 310
                          330       340       350
                   ....*....|....*....|....*....|....*.
gi 124302198  1889 ANTNLSKFR--KVQHELDEAEERADIAESQVNKLRA 1922
Cdd:pfam07888  311 QSAEADKDRieKLSAELQRLEERLQEERMEREKLEV 346
PLN03229 PLN03229
acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Provisional
852-1106 1.45e-03

acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Provisional


Pssm-ID: 178768 [Multi-domain]  Cd Length: 762  Bit Score: 43.69  E-value: 1.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  852 MKEEFTRLKEALEKSEARRK----ELEEKMVSLLQEKN------------DLQLQVQAEQDNLADAEERCDQLIKNKIQL 915
Cdd:PLN03229  484 LQERLENLREEFSKANSQDQlmhpVLMEKIEKLKDEFNkrlsrapnylslKYKLDMLNEFSRAKALSEKKSKAEKLKAEI 563
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  916 EAKVKEMNERLEDEEEMNAeltakkRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMaGLDEIIAKltke 995
Cdd:PLN03229  564 NKKFKEVMDRPEIKEKMEA------LKAEVASSGASSGDELDDDLKEKVEKMKKEIELELAGVLKSM-GLEVIGVT---- 632
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  996 KKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKkvrmdLERAKRKLEGDLKlTQESIMDLEND-KQ 1074
Cdd:PLN03229  633 KKNKDTAEQTPPPNLQEKIESLNEEINKKIERVIRSSDLKSKIELLK-----LEVAKASKTPDVT-EKEKIEALEQQiKQ 706
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 124302198 1075 QLDE-----RLKKKDFELNA-LNARIEDEQALGSQLQK 1106
Cdd:PLN03229  707 KIAEalnssELKEKFEELEAeLAAARETAAESNGSLKN 744
PLN03188 PLN03188
kinesin-12 family protein; Provisional
1649-1923 1.50e-03

kinesin-12 family protein; Provisional


Pssm-ID: 215621 [Multi-domain]  Cd Length: 1320  Bit Score: 43.77  E-value: 1.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1649 LLKDTQIQLDDAVRANDDLKEniaiverrnnlLQAELEELRAVVEQTERSRKLAE-QELietseRVQLLHSQNTSLINQK 1727
Cdd:PLN03188  951 LLKEKYENHPEVLRTKIELKR-----------VQDELEHYRNFYDMGEREVLLEEiQDL-----RSQLQYYIDSSLPSAR 1014
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1728 KK---------MDADLSQLQTEVEEAVQECrnAEEKAKK-------AITDAAMMAEELKKEQDTSAHLERMKKNMEQTIK 1791
Cdd:PLN03188 1015 KRnsllkltysCEPSQAPPLNTIPESTDES--PEKKLEQerlrwteAESKWISLAEELRTELDASRALAEKQKHELDTEK 1092
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1792 DLQHRLDEAEQIALKGGKKQLQK----------LEARVRELENELEAEQKrnAESVKGMRKSERR--------IKELTYQ 1853
Cdd:PLN03188 1093 RCAEELKEAMQMAMEGHARMLEQyadleekhiqLLARHRRIQEGIDDVKK--AAARAGVRGAESKfinalaaeISALKVE 1170
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 124302198 1854 TEEDRKnllRLQDLVDKLQLKVkaykRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAE-------SQVNKLRAK 1923
Cdd:PLN03188 1171 REKERR---YLRDENKSLQAQL----RDTAEAVQAAGELLVRLKEAEEALTVAQKRAMDAEqeaaeayKQIDKLKRK 1240
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1388-1619 1.54e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 43.21  E-value: 1.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1388 EAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSEL 1467
Cdd:COG4942    20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAEL 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1468 ESSQKEARSLSTELFKLKNAYEESL----EHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSA 1543
Cdd:COG4942   100 EAQKEELAELLRALYRLGRQPPLALllspEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEAL 179
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 124302198 1544 LEEAEASleheegkilraqlefnqiKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKME 1619
Cdd:COG4942   180 LAELEEE------------------RAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAA 237
Mitofilin pfam09731
Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. ...
846-1115 1.62e-03

Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.


Pssm-ID: 430783 [Multi-domain]  Cd Length: 618  Bit Score: 43.21  E-value: 1.62e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   846 EKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDN--LADAEERCDQLIKNKIQLEAKVKEmN 923
Cdd:pfam09731  160 KAHTDSLKEASDTAEISREKATDSALQKAEALAEKLKEVINLAKQSEEEAAPplLDAAPETPPKLPEHLDNVEEKVEK-A 238
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   924 ERLEDEEEMNAELTAKKRklEDECSELKRDIDDLELTLAKVEKEKHATENKVknLTEEMAGLDEIIAKLTKEKKALQEAH 1003
Cdd:pfam09731  239 QSLAKLVDQYKELVASER--IVFQQELVSIFPDIIPVLKEDNLLSNDDLNSL--IAHAHREIDQLSKKLAELKKREEKHI 314
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1004 QQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMD-----LENDKQQLDE 1078
Cdd:pfam09731  315 ERALEKQKEELDKLAEELSARLEEVRAADEAQLRLEFEREREEIRESYEEKLRTELERQAEAHEEhlkdvLVEQEIELQR 394
                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 124302198  1079 RLKKKdfelnaLNARIEDEQALgsqLQKKLKELQARI 1115
Cdd:pfam09731  395 EFLQD------IKEKVEEERAG---RLLKLNELLANL 422
ATG14 pfam10186
Vacuolar sorting 38 and autophagy-related subunit 14; The Atg14 or Apg14 proteins are ...
852-998 1.72e-03

Vacuolar sorting 38 and autophagy-related subunit 14; The Atg14 or Apg14 proteins are hydrophilic proteins with a predicted molecular mass of 40.5 kDa, and have a coiled-coil motif at the N terminus region. Yeast cells with mutant Atg14 are defective not only in autophagy but also in sorting of carboxypeptidase Y (CPY), a vacuolar-soluble hydrolase, to the vacuole. Subcellular fractionation indicate that Apg14p and Apg6p are peripherally associated with a membrane structure(s). Apg14p was co-immunoprecipitated with Apg6p, suggesting that they form a stable protein complex. These results imply that Apg6/Vps30p has two distinct functions: in the autophagic process and in the vacuolar protein sorting pathway. Apg14p may be a component specifically required for the function of Apg6/Vps30p through the autophagic pathway. There are 17 auto-phagosomal component proteins which are categorized into six functional units, one of which is the AS-PI3K complex (Vps30/Atg6 and Atg14). The AS-PI3K complex and the Atg2-Atg18 complex are essential for nucleation, and the specific function of the AS-PI3K apparently is to produce phosphatidylinositol 3-phosphate (PtdIns(3)P) at the pre-autophagosomal structure (PAS). The localization of this complex at the PAS is controlled by Atg14. Autophagy mediates the cellular response to nutrient deprivation, protein aggregation, and pathogen invasion in humans, and malfunction of autophagy has been implicated in multiple human diseases including cancer. This effect seems to be mediated through direct interaction of the human Atg14 with Beclin 1 in the human phosphatidylinositol 3-kinase class III complex.


Pssm-ID: 462986 [Multi-domain]  Cd Length: 347  Bit Score: 42.83  E-value: 1.72e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   852 MKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAeercdQLIKNKI-QLEAKVKEMNERLEdee 930
Cdd:pfam10186   17 ARNRLYELRVDLARLLSEKDSLKKKVEEALEGKEEGEQLEDNIGNKKLKL-----RLLKSEVaISNERLNEIKDKLD--- 88
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 124302198   931 EMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKA 998
Cdd:pfam10186   89 QLRREIAEKKKKIEKLRSSLKQRRSDLESASYQLEERRASQLAKLQNSIKRIKQKWTALHSKTAESRS 156
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
1562-1836 1.77e-03

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 43.50  E-value: 1.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1562 QLEFNQIKAEIERklAEKDEEMEQAKrnhlrVVDSLQTSLDAetrsrnealrvkkkmegdLNEMEIqlshANRMAAEAQK 1641
Cdd:PRK10929   22 APDEKQITQELEQ--AKAAKTPAQAE-----IVEALQSALNW------------------LEERKG----SLERAKQYQQ 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1642 QVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAE---LEELRAVVEQTERSRKLAE-------------QE 1705
Cdd:PRK10929   73 VIDNFPKLSAELRQQLNNERDEPRSVPPNMSTDALEQEILQVSsqlLEKSRQAQQEQDRAREISDslsqlpqqqtearRQ 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1706 LIETSERVQLLHSQNTSLiNQkkkmdADLSQLQteveeavqecrnAEEKAKKAITDaammaeELKkeqdtsahLERMKKN 1785
Cdd:PRK10929  153 LNEIERRLQTLGTPNTPL-AQ-----AQLTALQ------------AESAALKALVD------ELE--------LAQLSAN 200
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 124302198 1786 MEQTIKDLQHRLdeaeqialkgGKKQLQKLEARVRELENELEAEQKRNAES 1836
Cdd:PRK10929  201 NRQELARLRSEL----------AKKRSQQLDAYLQALRNQLNSQRQREAER 241
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
1273-1909 1.78e-03

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 43.27  E-value: 1.78e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1273 LTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTY--------------------------------TQQLEDLKRQLE 1320
Cdd:pfam10174    1 LQAQLRDLQRENELLRRELDIKESKLGSSMNSIKTFwspelkkeralrkeeaarisvlkeqyrvtqeeNQHLQLTIQALQ 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1321 EEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSevaqwRTKYETDAIQRT-EELE------------ 1387
Cdd:pfam10174   81 DELRAQRDLNQLLQQDFTTSPVDGEDKFSTPELTEENFRRLQSEHE-----RQAKELFLLRKTlEEMElrietqkqtlga 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1388 --EAKKKLAQRLQ------EAEEAVEAVNAKCSSLEKTKHRL-----QNEIEDLMVDVE-RSNAAAAALDKKQRNFDKIL 1453
Cdd:pfam10174  156 rdESIKKLLEMLQskglpkKSGEEDWERTRRIAEAEMQLGHLevlldQKEKENIHLREElHRRNQLQPDPAKTKALQTVI 235
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1454 AEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQL 1533
Cdd:pfam10174  236 EMKDTKISSLERNIRDLEDEVQMLKTNGLLHTEDREEEIKQMEVYKSHSKFMKNKIDQLKQELSKKESELLALQTKLETL 315
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1534 EAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKlaekdEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALR 1613
Cdd:pfam10174  316 TNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEK-----ESFLNKKTKQLQDLTEEKSTLAGEIRDLKDMLD 390
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1614 VKKK----MEGDLNEMEIQLSHANRMAAEAQKQVKSLQ-------SLLKDTQIQLDDAVRANDDLKENIaivERRNNLLQ 1682
Cdd:pfam10174  391 VKERkinvLQKKIENLQEQLRDKDKQLAGLKERVKSLQtdssntdTALTTLEEALSEKERIIERLKEQR---EREDRERL 467
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1683 AELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAitda 1762
Cdd:pfam10174  468 EELESLKKENKDLKEKVSALQPELTEKESSLIDLKEHASSLASSGLKKDSKLKSLEIAVEQKKEECSKLENQLKKA---- 543
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1763 ammaeelkkeqDTSAHLERMKKNMEQTIKDLQHrldEAEQIALKGGKKQ--LQKLEARVRELENELEAEQKRNAE----- 1835
Cdd:pfam10174  544 -----------HNAEEAVRTNPEINDRIRLLEQ---EVARYKEESGKAQaeVERLLGILREVENEKNDKDKKIAEleslt 609
                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 124302198  1836 --SVKGMRKSERRIKELtyQTEEDRKNLLRLQD-LVDKLQLKVKAYKRQAEEAeeqantnLSKFRKVQHELDEAEER 1909
Cdd:pfam10174  610 lrQMKEQNKKVANIKHG--QQEMKKKGAQLLEEaRRREDNLADNSQQLQLEEL-------MGALEKTRQELDATKAR 677
PRK11281 PRK11281
mechanosensitive channel MscK;
923-1319 2.00e-03

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 43.36  E-value: 2.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  923 NERLEDEEEMNAEL-TAKKRKLEDEcsELKRDIDDLELTL---AKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKA 998
Cdd:PRK11281   32 NGDLPTEADVQAQLdALNKQKLLEA--EDKLVQQDLEQTLallDKIDRQKEETEQLKQQLAQAPAKLRQAQAELEALKDD 109
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  999 LQEAHQQALDDLQAEEdkvntltkakvkLEQQVDDLEGSLEQekkVRMDL--------------ERAKRKLEGDLKLTQE 1064
Cdd:PRK11281  110 NDEETRETLSTLSLRQ------------LESRLAQTLDQLQN---AQNDLaeynsqlvslqtqpERAQAALYANSQRLQQ 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1065 ----SIMDLENDKQQLDERLKKKDFELNALNARIEDEQAL---GSQLQ----KKLKELQARIEELEEELEAERTArakVE 1133
Cdd:PRK11281  175 irnlLKGGKVGGKALRPSQRVLLQAEQALLNAQNDLQRKSlegNTQLQdllqKQRDYLTARIQRLEHQLQLLQEA---IN 251
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1134 KLRSDLSRELEEISERLEEAGgatsvQIEMNK--KREAEF-QKMRRDLEEATLQ-HEATAAALRKKHA-DSVAE----LG 1204
Cdd:PRK11281  252 SKRLTLSEKTVQEAQSQDEAA-----RIQANPlvAQELEInLQLSQRLLKATEKlNTLTQQNLRVKNWlDRLTQsernIK 326
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1205 EQIDNLQ------RV--KQKLekeksefKLELDDVTSNM-EQIikakANLekmcRTLEDQMNEHRSKAEETQRSVNDLts 1275
Cdd:PRK11281  327 EQISVLKgslllsRIlyQQQQ-------ALPSADLIEGLaDRI----ADL----RLEQFEINQQRDALFQPDAYIDKL-- 389
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 124302198 1276 qrakLQTENGELSRQldEKEALISQL-TRGKLtytqqLEDLKRQL 1319
Cdd:PRK11281  390 ----EAGHKSEVTDE--VRDALLQLLdERREL-----LDQLNKQL 423
F-BAR_PSTPIP2 cd07672
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Proline-Serine-Threonine ...
1232-1424 2.09e-03

The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Proline-Serine-Threonine Phosphatase-Interacting Protein 2; F-BAR domains are dimerization modules that bind and bend membranes and are found in proteins involved in membrane dynamics and actin reorganization. Proline-Serine-Threonine Phosphatase-Interacting Protein 2 (PSTPIP2), also known as Macrophage Actin-associated tYrosine Phosphorylated protein (MAYP), is mostly expressed in hematopoietic cells but is also expressed in the brain. It is involved in regulating cell adhesion and motility. Mutations in the gene encoding murine PSTPIP2 can cause autoinflammatory disorders such as chronic multifocal osteomyelitis and macrophage autoinflammatory disease. PSTPIP2 contains an N-terminal F-BAR domain and lacks the PEST motifs and SH3 domain that are found in PSTPIP1. F-BAR domains form banana-shaped dimers with a positively-charged concave surface that binds to negatively-charged lipid membranes. They can induce membrane deformation in the form of long tubules.


Pssm-ID: 153356 [Multi-domain]  Cd Length: 240  Bit Score: 41.86  E-value: 2.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1232 TSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQ 1311
Cdd:cd07672     4 TGGYDCIIQHLNDGRKNCKEFEDFLKERASIEEKYGKELLNLSKKKPCGQTEINTLKRSLDVFKQQIDNVGQSHIQLAQT 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1312 LEDLKRQLE---EEVKAKNALAHALQSARHDCDLLreQYEEETEAKAEL-QRVLSKANSEVAQWRTKYETDAIQRteelE 1387
Cdd:cd07672    84 LRDEAKKMEdfrERQKLARKKIELIMDAIHKQRAM--QFKKTMESKKNYeQKCRDKDEAEQAVNRNANLVNVKQQ----E 157
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 124302198 1388 EAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNE 1424
Cdd:cd07672   158 KLFAKLAQSKQNAEDADRLYMQNISVLDKIREDWQKE 194
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
846-1036 2.23e-03

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 43.29  E-value: 2.23e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   846 EKEMASMKEEFTR-LKEALEKSEARRKELEE----KMVSLLQEKNDLQLQVQAEQDNLAdaEERCDQLIK------NKIQ 914
Cdd:pfam12128  695 DKKHQAWLEEQKEqKREARTEKQAYWQVVEGaldaQLALLKAAIAARRSGAKAELKALE--TWYKRDLASlgvdpdVIAK 772
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   915 LEAKVKEMNERLEDEEEMNAE------------------LTAKKRKLEDECSELK----RDIDDLELTLAKVEKEKHATE 972
Cdd:pfam12128  773 LKREIRTLERKIERIAVRRQEvlryfdwyqetwlqrrprLATQLSNIERAISELQqqlaRLIADTKLRRAKLEMERKASE 852
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 124302198   973 NKVKNLTEEMAGLDEIIAKLT--KEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEG 1036
Cdd:pfam12128  853 KQQVRLSENLRGLRCEMSKLAtlKEDANSEQAQGSIGERLAQLEDLKLKRDYLSESVKKYVEHFKN 918
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
841-1082 2.62e-03

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 42.57  E-value: 2.62e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   841 KSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVK 920
Cdd:pfam07888  144 RVLERETELERMKERAKKAGAQRKEEEAERKQLQAKLQQTEEELRSLSKEFQELRNSLAQRDTQVLQLQDTITTLTQKLT 223
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   921 EMNERLEDEEEMNAELTAKKRKLE--DECSE-LKRDIDDLELTLAKVEKEKHATENKVKNLTEEMA----GLDEIIAKLT 993
Cdd:pfam07888  224 TAHRKEAENEALLEELRSLQERLNasERKVEgLGEELSSMAAQRDRTQAELHQARLQAAQLTLQLAdaslALREGRARWA 303
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   994 KEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKV-RMDLERAKRKLE---GDLKLTQESIMDL 1069
Cdd:pfam07888  304 QERETLQQSAEADKDRIEKLSAELQRLEERLQEERMEREKLEVELGREKDCnRVQLSESRRELQelkASLRVAQKEKEQL 383
                          250
                   ....*....|...
gi 124302198  1070 ENDKQQLDERLKK 1082
Cdd:pfam07888  384 QAEKQELLEYIRQ 396
HMMR_N pfam15905
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ...
1585-1859 2.65e-03

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.


Pssm-ID: 464932 [Multi-domain]  Cd Length: 329  Bit Score: 42.11  E-value: 2.65e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1585 QAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSllkdtqiQLDDAVRAN 1664
Cdd:pfam15905   66 QKNLKESKDQKELEKEIRALVQERGEQDKRLQALEEELEKVEAKLNAAVREKTSLSASVASLEK-------QLLELTRVN 138
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1665 DDLKENIAI--VERRNNLLQAELEELRAVVEQTERSrKLAEQELIEtserVQLLHSQNTslINQKKKMDADLSQLQTEVE 1742
Cdd:pfam15905  139 ELLKAKFSEdgTQKKMSSLSMELMKLRNKLEAKMKE-VMAKQEGME----GKLQVTQKN--LEHSKGKVAQLEEKLVSTE 211
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1743 EAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIAlkggKKQLQKLEARVREL 1822
Cdd:pfam15905  212 KEKIEEKSETEKLLEYITELSCVSEQVEKYKLDIAQLEELLKEKNDEIESLKQSLEEKEQEL----SKQIKDLNEKCKLL 287
                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 124302198  1823 ENELEAEQKRNAESVKGMRKSERRIKE-LTYQTEEDRK 1859
Cdd:pfam15905  288 ESEKEELLREYEEKEQTLNAELEELKEkLTLEEQEHQK 325
RecN COG0497
DNA repair ATPase RecN [Replication, recombination and repair];
1001-1263 2.68e-03

DNA repair ATPase RecN [Replication, recombination and repair];


Pssm-ID: 440263 [Multi-domain]  Cd Length: 555  Bit Score: 42.75  E-value: 2.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1001 EAHQQALD---DLQAEEDKVNTLTKAKVKLEQQVDDLEGSlEQEKKVRMD-LERAKRKLEgDLKLTQESIMDLENDKQQL 1076
Cdd:COG0497   141 DAQRELLDafaGLEELLEEYREAYRAWRALKKELEELRAD-EAERARELDlLRFQLEELE-AAALQPGEEEELEEERRRL 218
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1077 D--ERLKKKDFE-LNALNariEDEQALGSQLQKklkelqarieeleeeleaertARAKVEKLrSDLSRELEEISERLEEA 1153
Cdd:COG0497   219 SnaEKLREALQEaLEALS---GGEGGALDLLGQ---------------------ALRALERL-AEYDPSLAELAERLESA 273
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1154 ggatSVQIEmnkkrEA--EFQKMRRDLE------EATLQHEATAAALRKKHADSVAELgeqIDNLQRVKQKLEkeksefk 1225
Cdd:COG0497   274 ----LIELE-----EAasELRRYLDSLEfdperlEEVEERLALLRRLARKYGVTVEEL---LAYAEELRAELA------- 334
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 124302198 1226 lELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKA 1263
Cdd:COG0497   335 -ELENSDERLEELEAELAEAEAELLEAAEKLSAARKKA 371
Tropomyosin pfam00261
Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 ...
847-1043 2.75e-03

Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 parallel helices containing 2 sets of 7 alternating actin binding sites. The protein is best known for its role in regulating the interaction between actin and myosin in muscle contraction, but is also involved in the organization and dynamics of the cytoskeleton in non-muscle cells. There are multiple cell-specific isoforms, expressed by alternative promoters and alternative RNA processing of at least four genes. Muscle isoforms of tropomyosin are characterized by having 284 amino acid residues and a highly conserved N-terminal region, whereas non-muscle forms are generally smaller and are heterogeneous in their N-terminal region.


Pssm-ID: 459736 [Multi-domain]  Cd Length: 235  Bit Score: 41.55  E-value: 2.75e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   847 KEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEM---- 922
Cdd:pfam00261    1 KKMQQIKEELDEAEERLKEAMKKLEEAEKRAEKAEAEVAALNRRIQLLEEELERTEERLAEALEKLEEAEKAADESergr 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   923 ----NERLEDEEEMN---AELTAKKRKLED---ECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKL 992
Cdd:pfam00261   81 kvleNRALKDEEKMEileAQLKEAKEIAEEadrKYEEVARKLVVVEGDLERAEERAELAESKIVELEEELKVVGNNLKSL 160
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 124302198   993 -TKEKKALQ------EAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKK 1043
Cdd:pfam00261  161 eASEEKASEredkyeEQIRFLTEKLKEAETRAEFAERSVQKLEKEVDRLEDELEAEKE 218
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
949-1754 2.80e-03

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 43.02  E-value: 2.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  949 ELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAgldeiiaKLTKEKKALQEAHQQALDDLQaeedKVNTLTKAKVKLE 1028
Cdd:COG3096   282 ELSERALELRRELFGARRQLAEEQYRLVEMARELE-------ELSARESDLEQDYQAASDHLN----LVQTALRQQEKIE 350
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1029 QQVDDLEG---SLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLEN---DKQQ-LDERLKKKDFELNALNARIEDEQALG 1101
Cdd:COG3096   351 RYQEDLEElteRLEEQEEVVEEAAEQLAEAEARLEAAEEEVDSLKSqlaDYQQaLDVQQTRAIQYQQAVQALEKARALCG 430
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1102 ------SQLQKKLKELQARieeLEEELEAERTARAKVEkLRSDLSRELEEISERLEEAGGATSvqiemnkkREAEFQKMR 1175
Cdd:COG3096   431 lpdltpENAEDYLAAFRAK---EQQATEEVLELEQKLS-VADAARRQFEKAYELVCKIAGEVE--------RSQAWQTAR 498
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1176 RDLEEA-TLQHEA-TAAALRKKHADSVAELGEQidnlqrvkQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLE 1253
Cdd:COG3096   499 ELLRRYrSQQALAqRLQQLRAQLAELEQRLRQQ--------QNAERLLEEFCQRIGQQLDAAEELEELLAELEAQLEELE 570
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1254 DQMNEHRSKAEETQRSVNDLTSQRAKLqTENGELSRQLDEKEALISQLTRGKLTYTQQLED-LKRQLEEEVKAKNALAHA 1332
Cdd:COG3096   571 EQAAEAVEQRSELRQQLEQLRARIKEL-AARAPAWLAAQDALERLREQSGEALADSQEVTAaMQQLLEREREATVERDEL 649
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1333 LQSARHdcdlLREQYEEETEAK-AELQRVLSKAN-------SEVaqwrtkYETDAIQR----------------TEELEE 1388
Cdd:COG3096   650 AARKQA----LESQIERLSQPGgAEDPRLLALAErlggvllSEI------YDDVTLEDapyfsalygparhaivVPDLSA 719
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1389 AKKKLAQR-----------------------LQEAEEAVEAVNAK---------------CSSLEKTKHRLQNEIEDLmv 1430
Cdd:COG3096   720 VKEQLAGLedcpedlyliegdpdsfddsvfdAEELEDAVVVKLSDrqwrysrfpevplfgRAAREKRLEELRAERDEL-- 797
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1431 dVERSNAAAAALDKKQR---NFDKILAEWKQkyeesqsELESSQKEArslstELFKLKNAYEESLEHLETFKRENKNLQE 1507
Cdd:COG3096   798 -AEQYAKASFDVQKLQRlhqAFSQFVGGHLA-------VAFAPDPEA-----ELAALRQRRSELERELAQHRAQEQQLRQ 864
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1508 EISDLTEQLGSSGKTIHEL-----EKVRKQLEAEKMELQSAlEEAEASLEhEEGKILRaQLE------------FNQIKA 1570
Cdd:COG3096   865 QLDQLKEQLQLLNKLLPQAnlladETLADRLEELREELDAA-QEAQAFIQ-QHGKALA-QLEplvavlqsdpeqFEQLQA 941
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1571 EIERKLAEKDEEMEQ--------AKRNHLRVVDSLQtsLDAETRSRNEALRVKkkmegdLNEMEIQLSHANRMAAEAQKQ 1642
Cdd:COG3096   942 DYLQAKEQQRRLKQQifalsevvQRRPHFSYEDAVG--LLGENSDLNEKLRAR------LEQAEEARREAREQLRQAQAQ 1013
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1643 VKSLQSLLKDtqiqLDDAVRA-NDDLKEniaiverrnnlLQAELEEL--RAVVEQTERSRklaeqelietsERVQLLHSQ 1719
Cdd:COG3096  1014 YSQYNQVLAS----LKSSRDAkQQTLQE-----------LEQELEELgvQADAEAEERAR-----------IRRDELHEE 1067
                         890       900       910
                  ....*....|....*....|....*....|....*
gi 124302198 1720 NTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEK 1754
Cdd:COG3096  1068 LSQNRSRRSQLEKQLTRCEAEMDSLQKRLRKAERD 1102
PRK10361 PRK10361
DNA recombination protein RmuC; Provisional
1762-1931 2.96e-03

DNA recombination protein RmuC; Provisional


Pssm-ID: 182409 [Multi-domain]  Cd Length: 475  Bit Score: 42.28  E-value: 2.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1762 AAMMAEELKKEQDTSAHLERMKKNMEQTikdlQHRLDEAEQI--ALKGGKKQLQKLEARVRELENELEAEQKRNAESVKG 1839
Cdd:PRK10361   28 AQQKAEQLAEREEMVAELSAAKQQITQS----EHWRAECELLnnEVRSLQSINTSLEADLREVTTRMEAAQQHADDKIRQ 103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1840 MRKSERRIKE----LTYQTEE------DRKNLLRLQDLVDKLQLKVKAYKRQAEEA---EEQANTNLSkfrkvqHELDEA 1906
Cdd:PRK10361  104 MINSEQRLSEqfenLANRIFEhsnrrvDEQNRQSLNSLLSPLREQLDGFRRQVQDSfgkEAQERHTLA------HEIRNL 177
                         170       180
                  ....*....|....*....|....*.
gi 124302198 1907 EE-RADIAESQVNKLRAKSRDIGTKG 1931
Cdd:PRK10361  178 QQlNAQMAQEAINLTRALKGDNKTQG 203
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
839-1112 2.97e-03

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 42.85  E-value: 2.97e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   839 LLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEekmvsllQEKNDLqlqvqaeQDNLADAEERCDQLIKNKIQLEAK 918
Cdd:pfam01576  825 LAQSKESEKKLKNLEAELLQLQEDLAASERARRQAQ-------QERDEL-------ADEIASGASGKSALQDEKRRLEAR 890
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   919 VKEMNERLEdEEEMNAELTAKK-RKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEmagldeiiakltkekk 997
Cdd:pfam01576  891 IAQLEEELE-EEQSNTELLNDRlRKSTLQVEQLTTELAAERSTSQKSESARQQLERQNKELKAK---------------- 953
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   998 alqeahqqalddLQAEEDKVNTLTKAKVK-LEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQL 1076
Cdd:pfam01576  954 ------------LQEMEGTVKSKFKSSIAaLEAKIAQLEEQLEQESRERQAANKLVRRTEKKLKEVLLQVEDERRHADQY 1021
                          250       260       270
                   ....*....|....*....|....*....|....*.
gi 124302198  1077 DERLKKKDFELNALNARIEDEQALGSQLQKKLKELQ 1112
Cdd:pfam01576 1022 KDQAEKGNSRMKQLKRQLEEAEEEASRANAARRKLQ 1057
Caldesmon pfam02029
Caldesmon;
1640-1886 2.98e-03

Caldesmon;


Pssm-ID: 460421 [Multi-domain]  Cd Length: 495  Bit Score: 42.55  E-value: 2.98e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1640 QKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHsQ 1719
Cdd:pfam02029   69 AKREERRQKRLQEALERQKEFDPTIADEKESVAERKENNEEEENSSWEKEEKRDSRLGRYKEEETEIREKEYQENKWS-T 147
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1720 NTSLINQKKKMDADLSQLQTEVE------EAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDL 1793
Cdd:pfam02029  148 EVRQAEEEGEEEEDKSEEAEEVPtenfakEEVKDEKIKKEKKVKYESKVFLDQKRGHPEVKSQNGEEEVTKLKVTTKRRQ 227
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1794 ----QHRLDEAEQIALKGGKKQLQKLEARVRELENElEAEQKRNA--------ESVKGMRKSERRIKELTYQTEEDRKNL 1861
Cdd:pfam02029  228 gglsQSQEREEEAEVFLEAEQKLEELRRRRQEKESE-EFEKLRQKqqeaelelEELKKKREERRKLLEEEEQRRKQEEAE 306
                          250       260
                   ....*....|....*....|....*
gi 124302198  1862 LRLQDLVDKLQLKVKAYKRQAEEAE 1886
Cdd:pfam02029  307 RKLREEEEKRRMKEEIERRRAEAAE 331
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
948-1248 3.13e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 42.20  E-value: 3.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  948 SELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKL 1027
Cdd:COG4372    27 AALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESL 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1028 EQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKK 1107
Cdd:COG4372   107 QEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAEAEQALD 186
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1108 LKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEA 1187
Cdd:COG4372   187 ELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKEIEELELA 266
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 124302198 1188 TAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKM 1248
Cdd:COG4372   267 ILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALLELAKK 327
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
902-1043 3.14e-03

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 41.93  E-value: 3.14e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198    902 EERCDQLIKNKIQLEAKVKEMNErleDEEEMNAELTakkrkledECSELKRDIDDLELTL-AKVEKEKHATENKVKNLTE 980
Cdd:smart00787  136 EWRMKLLEGLKEGLDENLEGLKE---DYKLLMKELE--------LLNSIKPKLRDRKDALeEELRQLKQLEDELEDCDPT 204
                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 124302198    981 EMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKK 1043
Cdd:smart00787  205 ELDRAKEKLKKLLQEIMIKVKKLEELEEELQELESKIEDLTNKKSELNTEIAEAEKKLEQCRG 267
PRK12704 PRK12704
phosphodiesterase; Provisional
1749-1914 3.33e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 42.07  E-value: 3.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1749 RNAEEKAKKAITDAAMMAEELKKEqdtsahLERMKKNMEQTIKDLQHRLdeaeqialkggkkqLQKLEARVRELENELEA 1828
Cdd:PRK12704   27 KIAEAKIKEAEEEAKRILEEAKKE------AEAIKKEALLEAKEEIHKL--------------RNEFEKELRERRNELQK 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1829 EQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQAnTNLSKFRKVQHELDEAEE 1908
Cdd:PRK12704   87 LEKRLLQKEENLDRKLELLEKREEELEKKEKELEQKQQELEKKEEELEELIEEQLQELERI-SGLTAEEAKEILLEKVEE 165

                  ....*...
gi 124302198 1909 --RADIAE 1914
Cdd:PRK12704  166 eaRHEAAV 173
FPP pfam05911
Filament-like plant protein, long coiled-coil; FPP is a family of long coiled-coil plant ...
1165-1320 3.49e-03

Filament-like plant protein, long coiled-coil; FPP is a family of long coiled-coil plant proteins that are filament-like. It interacts with the nuclear envelope-associated protein, MAF1, the WPP family pfam13943.


Pssm-ID: 461778 [Multi-domain]  Cd Length: 859  Bit Score: 42.35  E-value: 3.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1165 KKREAEFQKMRRDLEEATLQheATAAALRKKHADS-VAELGEQIDNLqrvkqkleKEKSEFKLElddvtsnmEQIIKAKA 1243
Cdd:pfam05911   20 EKAEAEALALKQQLESVTLQ--KLTAEERAAHLDGaLKECMQQLRNV--------KEEQEQKIH--------DVVLKKTK 81
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 124302198  1244 NLEKMCRTLEDQMNEhrskaeetqrsvndlTSQR-AKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLE 1320
Cdd:pfam05911   82 EWEKIKAELEAKLVE---------------TEQElLRAAAENDALSRSLQERENLLMKLSEEKSQAEAEIEALKSRLE 144
DUF724 pfam05266
Protein of unknown function (DUF724); This family contains several uncharacterized proteins ...
1645-1754 3.58e-03

Protein of unknown function (DUF724); This family contains several uncharacterized proteins found in Arabidopsis thaliana and other plants. This region is often found associated with Agenet domains and may contain coiled-coil.


Pssm-ID: 428400 [Multi-domain]  Cd Length: 188  Bit Score: 40.72  E-value: 3.58e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1645 SLQSLLKDT-QIQLDDAVRANDDLKENIAIVE-----------RRNNLL---------QAELEELRAVVEQTERSRKLAE 1703
Cdd:pfam05266   50 SFAGLLEKVkKLQVDDSRSVFESLMESFAELEkhgfdvkapqsRINKLLslkdrqtklLEELKKLEKKIAEEESEKRKLE 129
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 124302198  1704 QELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEK 1754
Cdd:pfam05266  130 EEIDELEKKILELERQLALAKEKKEAADKEIARLKSEAEKLEQEIQDVELE 180
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
843-1097 3.91e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.21  E-value: 3.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  843 AEREKEMASMKE---EFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIknkiqlEAKV 919
Cdd:COG4913   671 AELEAELERLDAssdDLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAE------DLAR 744
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  920 KEMNERLED--EEEMNAELTAKKRK-LEDECSELKRDIDDLELTLAKVEKE-KHATENKVKNLTEEMAGLDEIIAKLT-- 993
Cdd:COG4913   745 LELRALLEErfAAALGDAVERELREnLEERIDALRARLNRAEEELERAMRAfNREWPAETADLDADLESLPEYLALLDrl 824
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  994 ----------KEKKALQEAHQQALDDLQAEedkvntLTKAKVKLEQQVDDLEGSLEQ-----EKKVRMDLERAKRKlegD 1058
Cdd:COG4913   825 eedglpeyeeRFKELLNENSIEFVADLLSK------LRRAIREIKERIDPLNDSLKRipfgpGRYLRLEARPRPDP---E 895
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 124302198 1059 LKLTQESIMDLENDKQQLDERLKKKDFE-LNALNARIEDE 1097
Cdd:COG4913   896 VREFRQELRAVTSGASLFDEELSEARFAaLKRLIERLRSE 935
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
1275-1795 4.02e-03

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 42.25  E-value: 4.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1275 SQRAKLQTENGELSRQLDEKEALI--SQLTRGKLTYTQQLEDLKRQLEEEvkAKNALAHALQSARHDCDLLREQyeeETE 1352
Cdd:COG3096   215 SLRDYLLPENSGVRKAFQDMEAALreNRMTLEAIRVTQSDRDLFKHLITE--ATNYVAADYMRHANERRELSER---ALE 289
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1353 AKAELQRVLSKANSEvaQWRTKYETDAIqrtEELEEAKKKLAQRLQEAEEAVEAVnakcssleKTKHRLQNEIEDLMVDV 1432
Cdd:COG3096   290 LRRELFGARRQLAEE--QYRLVEMAREL---EELSARESDLEQDYQAASDHLNLV--------QTALRQQEKIERYQEDL 356
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1433 ErsnAAAAALDKKQrnfdKILAEWKQKYEESQSELESSQKEARSLSTELFKlknaYEESLEHLETfkrenKNLQEEisdl 1512
Cdd:COG3096   357 E---ELTERLEEQE----EVVEEAAEQLAEAEARLEAAEEEVDSLKSQLAD----YQQALDVQQT-----RAIQYQ---- 416
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1513 teqlgssgKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEgkilraqlEFNQIKAEIERKLAEKDEemeqAKRNHLR 1592
Cdd:COG3096   417 --------QAVQALEKARALCGLPDLTPENAEDYLAAFRAKEQ--------QATEEVLELEQKLSVADA----ARRQFEK 476
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1593 VVDSLQTSLDAETRSR-----NEALRV---KKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAvran 1664
Cdd:COG3096   477 AYELVCKIAGEVERSQawqtaRELLRRyrsQQALAQRLQQLRAQLAELEQRLRQQQNAERLLEEFCQRIGQQLDAA---- 552
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1665 DDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHsqntslinqkkKMDADLSQLQTEVEEA 1744
Cdd:COG3096   553 EELEELLAELEAQLEELEEQAAEAVEQRSELRQQLEQLRARIKELAARAPAWL-----------AAQDALERLREQSGEA 621
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....
gi 124302198 1745 VQECRnaeekakkAITDAamMAEELKKEQDTSA---HLERMKKNMEQTIKDLQH 1795
Cdd:COG3096   622 LADSQ--------EVTAA--MQQLLEREREATVerdELAARKQALESQIERLSQ 665
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
840-1017 4.04e-03

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 42.31  E-value: 4.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  840 LKSAEREKEmaSMKEEFTRLK-----------EALEKSEARRKELEEKMVSLlQEKNDLQ-------LQVQAEQDNLADA 901
Cdd:NF033838  206 IKQAKAKVE--SKKAEATRLEkiktdrekaeeEAKRRADAKLKEAVEKNVAT-SEQDKPKrrakrgvLGEPATPDKKEND 282
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  902 EERCDQLI-------------KNKIQLEAKVKEMNERLED--EEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEK 966
Cdd:NF033838  283 AKSSDSSVgeetlpspslkpeKKVAEAEKKVEEAKKKAKDqkEEDRRNYPTNTYKTLELEIAESDVKVKEAELELVKEEA 362
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 124302198  967 EKHATENKVKNLTEEMAGLDEIIAKLTK----EKKALQEAHQQAlddlqAEEDKV 1017
Cdd:NF033838  363 KEPRNEEKIKQAKAKVESKKAEATRLEKiktdRKKAEEEAKRKA-----AEEDKV 412
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
1771-1923 4.10e-03

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 42.04  E-value: 4.10e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1771 KEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGK------KQLQKLEARVRELENELEAEQKRNAESVKGMRKSE 1844
Cdd:pfam05557    3 ELIESKARLSQLQNEKKQMELEHKRARIELEKKASALKRqldresDRNQELQKRIRLLEKREAEAEEALREQAELNRLKK 82
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 124302198  1845 RRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAK 1923
Cdd:pfam05557   83 KYLEALNKKLNEKESQLADAREVISCLKNELSELRRQIQRAELELQSTNSELEELQERLDLLKAKASEAEQLRQNLEKQ 161
MARTX_Nterm NF012221
MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model ...
1254-1447 4.12e-03

MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model describes the N-terminal 1900 amino acids of MARTX family multifunctional-autoprocessing repeats-in-toxin holotoxins, which contain both repeat regions that facilitate their entry into eukaryotic target cells, and multiple effector domains.


Pssm-ID: 467957 [Multi-domain]  Cd Length: 1848  Bit Score: 42.51  E-value: 4.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1254 DQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEkealISQlTRGKLTYTQQledlkrqleeevkakNALAHAL 1333
Cdd:NF012221 1545 DAVSKHAKQDDAAQNALADKERAEADRQRLEQEKQQQLAA----ISG-SQSQLESTDQ---------------NALETNG 1604
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1334 QSARhdcDLLREQYEEETEAKAELQRVLSKANSEVA-------QWRTKYET---DAIQR---------TEELEEAKKKLA 1394
Cdd:NF012221 1605 QAQR---DAILEESRAVTKELTTLAQGLDALDSQATyagesgdQWRNPFAGgllDRVQEqlddakkisGKQLADAKQRHV 1681
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 124302198 1395 QRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNaaAAALDKKQR 1447
Cdd:NF012221 1682 DNQQKVKDAVAKSEAGVAQGEQNQANAEQDIDDAKADAEKRK--DDALAKQNE 1732
Tropomyosin pfam00261
Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 ...
1734-1920 4.24e-03

Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 parallel helices containing 2 sets of 7 alternating actin binding sites. The protein is best known for its role in regulating the interaction between actin and myosin in muscle contraction, but is also involved in the organization and dynamics of the cytoskeleton in non-muscle cells. There are multiple cell-specific isoforms, expressed by alternative promoters and alternative RNA processing of at least four genes. Muscle isoforms of tropomyosin are characterized by having 284 amino acid residues and a highly conserved N-terminal region, whereas non-muscle forms are generally smaller and are heterogeneous in their N-terminal region.


Pssm-ID: 459736 [Multi-domain]  Cd Length: 235  Bit Score: 40.78  E-value: 4.24e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1734 LSQLQTEVEEAVQECRNAEEK---AKKAITDAAMMAEELKKE-QDTSAHLERMKKNMEQTikdlQHRLDEAEQIA----- 1804
Cdd:pfam00261    3 MQQIKEELDEAEERLKEAMKKleeAEKRAEKAEAEVAALNRRiQLLEEELERTEERLAEA----LEKLEEAEKAAdeser 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1805 -LKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTE--EDRKNLL--RLQDLVDKLQL---KVK 1876
Cdd:pfam00261   79 gRKVLENRALKDEEKMEILEAQLKEAKEIAEEADRKYEEVARKLVVVEGDLEraEERAELAesKIVELEEELKVvgnNLK 158
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 124302198  1877 AYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKL 1920
Cdd:pfam00261  159 SLEASEEKASEREDKYEEQIRFLTEKLKEAETRAEFAERSVQKL 202
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
841-1098 4.51e-03

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 41.43  E-value: 4.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  841 KSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVK 920
Cdd:COG1340     2 KTDELSSSLEELEEKIEELREEIEELKEKRDELNEELKELAEKRDELNAQVKELREEAQELREKRDELNEKVKELKEERD 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  921 EMNERLedeEEMNAELTAKKRKLeDECSELKRDIDDLELTLAKVEKEKhatENKVKNLTEEMAGLDEiIAKLTKEKKALQ 1000
Cdd:COG1340    82 ELNEKL---NELREELDELRKEL-AELNKAGGSIDKLRKEIERLEWRQ---QTEVLSPEEEKELVEK-IKELEKELEKAK 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1001 EAHQQ------ALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQ 1074
Cdd:COG1340   154 KALEKneklkeLRAELKELRKEAEEIHKKIKELAEEAQELHEEMIELYKEADELRKEADELHKEIVEAQEKADELHEEII 233
                         250       260
                  ....*....|....*....|....
gi 124302198 1075 QLDERLKKKDFELNALNARIEDEQ 1098
Cdd:COG1340   234 ELQKELRELRKELKKLRKKQRALK 257
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
1788-1927 4.55e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 40.68  E-value: 4.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1788 QTIKDLQHRLDEAEQIA--LKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQ 1865
Cdd:COG1579     7 RALLDLQELDSELDRLEhrLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVR 86
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 124302198 1866 DL--VDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDI 1927
Cdd:COG1579    87 NNkeYEALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEE 150
Filament pfam00038
Intermediate filament protein;
1128-1361 4.61e-03

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 41.44  E-value: 4.61e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1128 ARAKVEKLRSDLSRELEEISERLEEaggatsvqiEMNKKR--EAEFQKMRRDLEEATLQH---EATA-------AALRKK 1195
Cdd:pfam00038   69 ERARLQLELDNLRLAAEDFRQKYED---------ELNLRTsaENDLVGLRKDLDEATLARvdlEAKIeslkeelAFLKKN 139
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1196 HADSVAELGEQIDNLQRVkqklekeksefkLELDDVTS-NMEQIIK-AKANLEKMC-RTLEDQMNEHRSKAEETQRSVND 1272
Cdd:pfam00038  140 HEEEVRELQAQVSDTQVN------------VEMDAARKlDLTSALAeIRAQYEEIAaKNREEAEEWYQSKLEELQQAAAR 207
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1273 LTSQRAKLQTENGELSRQLDEKEALISQLTRgkltytqQLEDLKRQLEEevkAKNALAHALQSARhdcDLLREQYEEETE 1352
Cdd:pfam00038  208 NGDALRSAKEEITELRRTIQSLEIELQSLKK-------QKASLERQLAE---TEERYELQLADYQ---ELISELEAELQE 274

                   ....*....
gi 124302198  1353 AKAELQRVL 1361
Cdd:pfam00038  275 TRQEMARQL 283
46 PHA02562
endonuclease subunit; Provisional
1483-1662 5.05e-03

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 41.54  E-value: 5.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1483 KLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQ----------------SALEE 1546
Cdd:PHA02562  217 RKQNKYDELVEEAKTIKAEIEELTDELLNLVMDIEDPSAALNKLNTAAAKIKSKIEQFQkvikmyekggvcptctQQISE 296
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1547 AEASLEHEEGKILRAQLEFNQIKAEIErKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEgdlnemE 1626
Cdd:PHA02562  297 GPDRITKIKDKLKELQHSLEKLDTAID-ELEEIMDEFNEQSKKLLELKNKISTNKQSLITLVDKAKKVKAAIE------E 369
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 124302198 1627 IQLSHANRmaaeaQKQVKSLQSLLKDTQIQLDDAVR 1662
Cdd:PHA02562  370 LQAEFVDN-----AEELAKLQDELDKIVKTKSELVK 400
GAS pfam13851
Growth-arrest specific micro-tubule binding; This family is the highly conserved central ...
950-1111 5.19e-03

Growth-arrest specific micro-tubule binding; This family is the highly conserved central region of a number of metazoan proteins referred to as growth-arrest proteins. In mouse, Gas8 is predominantly a testicular protein, whose expression is developmentally regulated during puberty and spermatogenesis. In humans, it is absent in infertile males who lack the ability to generate gametes. The localization of Gas8 in the motility apparatus of post-meiotic gametocytes and mature spermatozoa, together with the detection of Gas8 also in cilia at the apical surfaces of epithelial cells lining the pulmonary bronchi and Fallopian tubes suggests that the Gas8 protein may have a role in the functioning of motile cellular appendages. Gas8 is a microtubule-binding protein localized to regions of dynein regulation in mammalian cells.


Pssm-ID: 464001 [Multi-domain]  Cd Length: 200  Bit Score: 40.27  E-value: 5.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   950 LKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKAlQEAHQQALDDLQAeedKVNTLTKAKVKLEQ 1029
Cdd:pfam13851   31 LKEEIAELKKKEERNEKLMSEIQQENKRLTEPLQKAQEEVEELRKQLEN-YEKDKQSLKNLKA---RLKVLEKELKDLKW 106
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1030 QVDDLEgslEQEKKVRMDLERAKRKLEGDLKLTQESI----MDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQ 1105
Cdd:pfam13851  107 EHEVLE---QRFEKVERERDELYDKFEAAIQDVQQKTglknLLLEKKLQALGETLEKKEAQLNEVLAAANLDPDALQAVT 183

                   ....*.
gi 124302198  1106 KKLKEL 1111
Cdd:pfam13851  184 EKLEDV 189
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
841-1105 5.23e-03

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 41.75  E-value: 5.23e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   841 KSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKND--LQLQVQAEQDNLADAEERCDQLIKNKIQLEAK 918
Cdd:pfam12128  662 KQSEKDKKNKALAERKDSANERLNSLEAQLKQLDKKHQAWLEEQKEqkREARTEKQAYWQVVEGALDAQLALLKAAIAAR 741
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   919 VKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHA-------------------------TEN 973
Cdd:pfam12128  742 RSGAKAELKALETWYKRDLASLGVDPDVIAKLKREIRTLERKIERIAVRRQEvlryfdwyqetwlqrrprlatqlsnIER 821
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   974 KVKNLTEEMAGLDE----IIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLtkAKVKLEQQVDDLEGSLEQEKKVRMDLE 1049
Cdd:pfam12128  822 AISELQQQLARLIAdtklRRAKLEMERKASEKQQVRLSENLRGLRCEMSKL--ATLKEDANSEQAQGSIGERLAQLEDLK 899
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 124302198  1050 RAKRKLEGDLKLTQESIMDLENDKQQLD-----ERLKKKDFELNALNARIEDEQALGSQLQ 1105
Cdd:pfam12128  900 LKRDYLSESVKKYVEHFKNVIADHSGSGlaetwESLREEDHYQNDKGIRLLDYRKLVPYLE 960
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
841-1046 5.52e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 41.98  E-value: 5.52e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   841 KSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLqlqvqaeQDNLADAEERCDQLIKNKIQLEAKVK 920
Cdd:TIGR02169  834 EIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDL-------ESRLGDLKKERDELEAQLRELERKIE 906
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   921 EMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDL------ELTLAKVEKEKHAtenkvknLTEEMAGLDEIiakltk 994
Cdd:TIGR02169  907 ELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDeeipeeELSLEDVQAELQR-------VEEEIRALEPV------ 973
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 124302198   995 EKKALQEaHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEgslEQEKKVRM 1046
Cdd:TIGR02169  974 NMLAIQE-YEEVLKRLDELKEKRAKLEEERKAILERIEEYE---KKKREVFM 1021
WEMBL pfam05701
Weak chloroplast movement under blue light; WEMBL consists of several plant proteins required ...
1103-1575 5.54e-03

Weak chloroplast movement under blue light; WEMBL consists of several plant proteins required for the chloroplast avoidance response under high intensity blue light. This avoidance response consists in the relocation of chloroplasts on the anticlinal side of exposed cells. Acts in association with PMI2 to maintain the velocity of chloroplast photo-relocation movement via the regulation of cp-actin filaments. Thus several member-sequences are described as "myosin heavy chain-like".


Pssm-ID: 461718 [Multi-domain]  Cd Length: 562  Bit Score: 41.55  E-value: 5.54e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1103 QLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAggatsvQIE-MNKKREAEFQKMRRDLEEA 1181
Cdd:pfam05701   39 LVELELEKVQEEIPEYKKQSEAAEAAKAQVLEELESTKRLIEELKLNLERA------QTEeAQAKQDSELAKLRVEEMEQ 112
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1182 TLQHEATAAA------LRKKHADSVAELG---EQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQI-----------IKA 1241
Cdd:pfam05701  113 GIADEASVAAkaqlevAKARHAAAVAELKsvkEELESLRKEYASLVSERDIAIKRAEEAVSASKEIektveeltielIAT 192
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1242 KANLEkMCRTLEDQMNEHRSKA-------------------EETQR------SVNDLTSQ----RAKLQTENGELS---- 1288
Cdd:pfam05701  193 KESLE-SAHAAHLEAEEHRIGAalareqdklnwekelkqaeEELQRlnqqllSAKDLKSKletaSALLLDLKAELAayme 271
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1289 ------RQLDEKEALISQLTRGKLTYTQ-QLEDLKRQLE---EEVKAKNALAHALQS----ARHDCDLLREQYEEETEAK 1354
Cdd:pfam05701  272 sklkeeADGEGNEKKTSTSIQAALASAKkELEEVKANIEkakDEVNCLRVAAASLRSelekEKAELASLRQREGMASIAV 351
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1355 AELQRVLSKANSEVAQWRTKyETDAiqrTEELEEAKKKLAQRLQEAEEA-----------------VEAVNAKCSSLEKT 1417
Cdd:pfam05701  352 SSLEAELNRTKSEIALVQAK-EKEA---REKMVELPKQLQQAAQEAEEAkslaqaareelrkakeeAEQAKAAASTVESR 427
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1418 KHRLQNEIEDLMVDVERSNAAAAALDKKQrnfdkilaewkqkyeesqSELESSQKEARSLSTELfKLKNAYEESLEHLET 1497
Cdd:pfam05701  428 LEAVLKEIEAAKASEKLALAAIKALQESE------------------SSAESTNQEDSPRGVTL-SLEEYYELSKRAHEA 488
                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 124302198  1498 FKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEaslEHEEGKiLRAQLEFNQIKAEIERK 1575
Cdd:pfam05701  489 EELANKRVAEAVSQIEEAKESELRSLEKLEEVNREMEERKEALKIALEKAE---KAKEGK-LAAEQELRKWRAEHEQR 562
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
1440-1587 5.59e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 40.68  E-value: 5.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1440 AALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQE---------EIS 1510
Cdd:COG1579    13 QELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEqlgnvrnnkEYE 92
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 124302198 1511 DLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAK 1587
Cdd:COG1579    93 ALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAEREELA 169
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
1100-1429 5.75e-03

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 41.42  E-value: 5.75e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1100 LGSQLQKKLKEL-------QARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQ 1172
Cdd:pfam07888   32 LQNRLEECLQERaellqaqEAANRQREKEKERYKRDREQWERQRRELESRVAELKEELRQSREKHEELEEKYKELSASSE 111
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1173 KMRRDLEEATLQHEATAAALRKKHADSVAELGEQID---NLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMC 1249
Cdd:pfam07888  112 ELSEEKDALLAQRAAHEARIRELEEDIKTLTQRVLEretELERMKERAKKAGAQRKEEEAERKQLQAKLQQTEEELRSLS 191
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1250 RTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENgelsRQLDEKEALISQL--TRGKLTYTQQ-LEDLKRQLEEEVKAK 1326
Cdd:pfam07888  192 KEFQELRNSLAQRDTQVLQLQDTITTLTQKLTTAH----RKEAENEALLEELrsLQERLNASERkVEGLGEELSSMAAQR 267
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1327 NALAHALQSARHDCDLLREQYEE------ETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTE-------------ELE 1387
Cdd:pfam07888  268 DRTQAELHQARLQAAQLTLQLADaslalrEGRARWAQERETLQQSAEADKDRIEKLSAELQRLEerlqeermereklEVE 347
                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....
gi 124302198  1388 EAKKKLAQRLQEAEEAVEAVNAKCS--SLEKTKHRLQNEIEDLM 1429
Cdd:pfam07888  348 LGREKDCNRVQLSESRRELQELKASlrVAQKEKEQLQAEKQELL 391
growth_prot_Scy NF041483
polarized growth protein Scy;
1131-1856 5.91e-03

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 41.74  E-value: 5.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1131 KVEKLRSDLSRELEEISERLEEAGGATSVQIEmNKKREAEFQ--KMRRDLEEATLQHEATAAALRKKHADSVAEL----- 1203
Cdd:NF041483   44 QVEVLRAKLHEARRSLASRPAYDGADIGYQAE-QLLRNAQIQadQLRADAERELRDARAQTQRILQEHAEHQARLqaelh 122
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1204 GEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIikaKANLEKMCRTLedqMNEHRSKAE--------ETQRsVNDLTS 1275
Cdd:NF041483  123 TEAVQRRQQLDQELAERRQTVESHVNENVAWAEQL---RARTESQARRL---LDESRAEAEqalaaaraEAER-LAEEAR 195
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1276 QRAKLQTEN--GELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKN--ALAHALQSARHDCDLLREQYEEET 1351
Cdd:NF041483  196 QRLGSEAESarAEAEAILRRARKDAERLLNAASTQAQEATDHAEQLRSSTAAESdqARRQAAELSRAAEQRMQEAEEALR 275
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1352 EAKAELQRVLSKANSEVAQWRTKYETDAIQRTeelEEAKKKLAQRLQEAEEAVEAVNAKCsslEKTKHRLQNEIEDLMVD 1431
Cdd:NF041483  276 EARAEAEKVVAEAKEAAAKQLASAESANEQRT---RTAKEEIARLVGEATKEAEALKAEA---EQALADARAEAEKLVAE 349
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1432 VE---RSNAA---AAALDKKQRNFDKILAEwkqkyeesqselesSQKEARSLStelfklKNAYEESLEHLETFKRENKNL 1505
Cdd:NF041483  350 AAekaRTVAAedtAAQLAKAARTAEEVLTK--------------ASEDAKATT------RAAAEEAERIRREAEAEADRL 409
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1506 QEEISDLTEQLGSSGKtiheleKVRKQLEAEKMELQSaleeaEASLEHEEGKILRAQL--EFNQIKAEIERKLAEKDEEM 1583
Cdd:NF041483  410 RGEAADQAEQLKGAAK------DDTKEYRAKTVELQE-----EARRLRGEAEQLRAEAvaEGERIRGEARREAVQQIEEA 478
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1584 EQAKRNHLRV----VDSLQTSLDAET-RSRNEALRVKKKMEGDLNE-MEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQL 1657
Cdd:NF041483  479 ARTAEELLTKakadADELRSTATAESeRVRTEAIERATTLRRQAEEtLERTRAEAERLRAEAEEQAEEVRAAAERAAREL 558
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1658 -DDAVRANDDLKENIAIVERRnnlLQAELEELRAVVEQT--------ERSRKLAEQEL----IETSERVQLLHSQntsli 1724
Cdd:NF041483  559 rEETERAIAARQAEAAEELTR---LHTEAEERLTAAEEAladaraeaERIRREAAEETerlrTEAAERIRTLQAQ----- 630
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1725 nqkkkMDADLSQLQTE-VEEAVQECRNAEEKAKKAITDAAMMAEELKKE-QDTS--------AHLERMKKNMEQTIKDLQ 1794
Cdd:NF041483  631 -----AEQEAERLRTEaAADASAARAEGENVAVRLRSEAAAEAERLKSEaQESAdrvraeaaAAAERVGTEAAEALAAAQ 705
                         730       740       750       760       770       780       790
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 124302198 1795 H----RLDEAEQIaLKGGKKQLQKLEARVRELENELEAEQKR-----NAESVKGMRKSERRIKELTYQTEE 1856
Cdd:NF041483  706 EeaarRRREAEET-LGSARAEADQERERAREQSEELLASARKrveeaQAEAQRLVEEADRRATELVSAAEQ 775
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
1432-1705 5.92e-03

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 41.48  E-value: 5.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1432 VERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARslstelFKLKNAYEESLEHLETfkrENKNLQEEISD 1511
Cdd:COG5185   277 SKRLNENANNLIKQFENTKEKIAEYTKSIDIKKATESLEEQLAA------AEAEQELEESKRETET---GIQNLTAEIEQ 347
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1512 LTEQLGSSGKTIHElekvrkqlEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHL 1591
Cdd:COG5185   348 GQESLTENLEAIKE--------EIENIVGEVELSKSSEELDSFKDTIESTKESLDEIPQNQRGYAQEILATLEDTLKAAD 419
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1592 RVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEiQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENI 1671
Cdd:COG5185   420 RQIEELQRQIEQATSSNEEVSKLLNELISELNKVM-READEESQSRLEEAYDEINRSVRSKKEDLNEELTQIESRVSTLK 498
                         250       260       270
                  ....*....|....*....|....*....|....
gi 124302198 1672 AIVERRNNLLQAELEELRAVVEQTERSRKLAEQE 1705
Cdd:COG5185   499 ATLEKLRAKLERQLEGVRSKLDQVAESLKDFMRA 532
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
1525-1796 6.00e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 41.65  E-value: 6.00e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1525 ELEKVRkqLEAEKMELQSALEEaEASLEHEEGKIL-RAQLEFNQ----IKAEIERKLAEKDEEMEQAKRNHLRVVDSLQT 1599
Cdd:pfam17380  349 ELERIR--QEERKRELERIRQE-EIAMEISRMRELeRLQMERQQknerVRQELEAARKVKILEEERQRKIQQQKVEMEQI 425
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1600 SLDAETRSRNEALRVKKKMEgdlNEMEiqlshanRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNN 1679
Cdd:pfam17380  426 RAEQEEARQREVRRLEEERA---REME-------RVRLEEQERQQQVERLRQQEEERKRKKLELEKEKRDRKRAEEQRRK 495
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1680 LLQAELEELRAVVEQTERSRKLAEQELIEtservqllhSQNTSLINQKKKMDADLSQLQTEVEEavqecrnaeekaKKAI 1759
Cdd:pfam17380  496 ILEKELEERKQAMIEEERKRKLLEKEMEE---------RQKAIYEEERRREAEEERRKQQEMEE------------RRRI 554
                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 124302198  1760 TDAAMMAEELKKEQDTsahLERMKKNMEQTIKDLQHR 1796
Cdd:pfam17380  555 QEQMRKATEERSRLEA---MEREREMMRQIVESEKAR 588
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
1396-1589 6.23e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 40.29  E-value: 6.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1396 RLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKyeesqselessqkeAR 1475
Cdd:COG1579    11 DLQELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEAR--------------IK 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1476 SLSTELFKLKNAYE-ESLEH-LETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEh 1553
Cdd:COG1579    77 KYEEQLGNVRNNKEyEALQKeIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELE- 155
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 124302198 1554 EEGKILRAQLEfnQIKAEIERKLAEKDEEMEQAKRN 1589
Cdd:COG1579   156 AELEELEAERE--ELAAKIPPELLALYERIRKRKNG 189
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
1071-1428 6.28e-03

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 41.86  E-value: 6.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1071 NDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAE-------RTARAKVEKLRSdLSREL 1143
Cdd:COG3096   278 NERRELSERALELRRELFGARRQLAEEQYRLVEMARELEELSARESDLEQDYQAAsdhlnlvQTALRQQEKIER-YQEDL 356
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1144 EEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQ------------------HEATAAALRKKHADSVAELGe 1205
Cdd:COG3096   357 EELTERLEEQEEVVEEAAEQLAEAEARLEAAEEEVDSLKSQladyqqaldvqqtraiqyQQAVQALEKARALCGLPDLT- 435
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1206 qIDNlqrvkqkLEKEKSEFKLELDDVTSNMEQiIKAKANLEKMCRTLEDQMNE---------HRSKAEETQRSV-NDLTS 1275
Cdd:COG3096   436 -PEN-------AEDYLAAFRAKEQQATEEVLE-LEQKLSVADAARRQFEKAYElvckiagevERSQAWQTARELlRRYRS 506
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1276 QRAKLQTENGeLSRQLDEKEALISQLTRGKltytQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKA 1355
Cdd:COG3096   507 QQALAQRLQQ-LRAQLAELEQRLRQQQNAE----RLLEEFCQRIGQQLDAAEELEELLAELEAQLEELEEQAAEAVEQRS 581
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1356 ELQRVLSKANSEVAQ-------WRT---KYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKcSSLEKTKHRLQNEI 1425
Cdd:COG3096   582 ELRQQLEQLRARIKElaarapaWLAaqdALERLREQSGEALADSQEVTAAMQQLLEREREATVER-DELAARKQALESQI 660

                  ...
gi 124302198 1426 EDL 1428
Cdd:COG3096   661 ERL 663
IFT57 pfam10498
Intra-flagellar transport protein 57; Eukaryotic cilia and flagella are specialized organelles ...
896-1166 6.39e-03

Intra-flagellar transport protein 57; Eukaryotic cilia and flagella are specialized organelles found at the periphery of cells of diverse organizms. Intra-flagellar transport (IFT) is required for the assembly and maintenance of eukaryotic cilia and flagella, and consists of the bidirectional movement of large protein particles between the base and the distal tip of the organelle. IFT particles contain multiple copies of two distinct protein complexes, A and B, which contain at least 6 and 11 protein subunits. IFT57 is part of complex B but is not, however, required for the core subunits to stay associated. This protein is known as Huntington-interacting protein-1 in humans.


Pssm-ID: 463118 [Multi-domain]  Cd Length: 360  Bit Score: 41.09  E-value: 6.39e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   896 DNLADAEercdqLIKNKIQLEAKVKEMNERLEDEEEMnaeltakkrkledecselkrDIDDLELTLAKVEKEKHATENKV 975
Cdd:pfam10498  107 DDLADEA-----LKRKNFKWKKPKYPPEEEFEEEDVV--------------------EEDDAELTLEKVEEEMLIEGDDF 161
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   976 KNLTEEmaglDEIIAKLTKEKKALQEAHQQALD------DLQAEEDKVntLTKAKVKLEQQVDDLEGSLEQ----EKKVR 1045
Cdd:pfam10498  162 KEDDED----EDLYNESTKGEEAESSKPREIIEsnvdaaEWKLELERV--LPQLKVTIKADAKDWRAHLEQmkqhKKSIE 235
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  1046 MDLERAK---RKLEGDLKLTQESIMDLE---NdkQQLDERLKkkdfELNALNARIedeqalgSQLQKKLKELQARIeele 1119
Cdd:pfam10498  236 ESLPDTKsqlDKLHTDISKTLEKIESREkyiN--SQLEPLIQ----EYREAQDEL-------SEVQEKYKQLSEGV---- 298
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*..
gi 124302198  1120 eeleaertarakveklrSDLSRELEEISERLEeaggatSVQIEMNKK 1166
Cdd:pfam10498  299 -----------------TERTRELAEITEELE------KVKQEMEER 322
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
846-989 6.43e-03

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 40.77  E-value: 6.43e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198    846 EKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQleaKVKEMNER 925
Cdd:smart00787  157 KEDYKLLMKELELLNSIKPKLRDRKDALEEELRQLKQLEDELEDCDPTELDRAKEKLKKLLQEIMIKVK---KLEELEEE 233
                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 124302198    926 LEDEEEMNAELTAKKRKLEDECSELKR-----------DIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEII 989
Cdd:smart00787  234 LQELESKIEDLTNKKSELNTEIAEAEKkleqcrgftfkEIEKLKEQLKLLQSLTGWKITKLSGNTLSMTYDREIN 308
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
843-1151 6.48e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 41.04  E-value: 6.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  843 AEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEM 922
Cdd:COG4372    27 AALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESL 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  923 NERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKE------K 996
Cdd:COG4372   107 QEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAeaeqalD 186
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  997 KALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQL 1076
Cdd:COG4372   187 ELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKEIEELELA 266
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 124302198 1077 DERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLE 1151
Cdd:COG4372   267 ILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALLELAKKLELALAILLAELAD 341
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
1368-1507 6.77e-03

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 41.35  E-value: 6.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1368 VAQWRTKYETDA------IQRTEELEeakKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERsnAAAAA 1441
Cdd:PRK00409  504 IEEAKKLIGEDKeklnelIASLEELE---RELEQKAEEAEALLKEAEKLKEELEEKKEKLQEEEDKLLEEAEK--EAQQA 578
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 124302198 1442 LDKKQRNFDKILAEWKQKYEESQSELES-SQKEARSlstelfKLKNAYEESLEHLETFKRENKNLQE 1507
Cdd:PRK00409  579 IKEAKKEADEIIKELRQLQKGGYASVKAhELIEARK------RLNKANEKKEKKKKKQKEKQEELKV 639
ClyA_Cry6Aa-like cd22656
Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes ...
864-1001 7.23e-03

Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes pesticidal Cry6Aa toxin from Bacillus thuringiensis, one of the many parasporal crystal (Cry) toxins produced during the sporulation phase of growth. Many of these proteins are toxic to numerous insect species and have been effectively used as proteinaceous insecticides to directly kill insect pests; some have been used to control insect growth on transgenic agricultural plants. Cry6Aa exists as a protoxin, which is activated by cleavage using trypsin. Structure studies for Cry6Aa support a mechanism of action by pore formation, similar to cytolysin A (ClyA)-type alpha pore-forming toxins (alpha-PFTs) such as HblB, and bioassay and mutation studies show that Cry6Aa is an active pore-forming toxin. Cry6Aa shows atypical features compared to other members of alpha-PFTs, including internal repeat sequences and small loop regions within major alpha helices.


Pssm-ID: 439154 [Multi-domain]  Cd Length: 309  Bit Score: 40.82  E-value: 7.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  864 EKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDqliKNKIQLEAKVKEMNERLEDEEEMN-----AELTA 938
Cdd:cd22656   110 EELEEAKKTIKALLDDLLKEAKKYQDKAAKVVDKLTDFENQTE---KDQTALETLEKALKDLLTDEGGAIarkeiKDLQK 186
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 124302198  939 KKRKLEDEC-SELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQE 1001
Cdd:cd22656   187 ELEKLNEEYaAKLKAKIDELKALIADDEAKLAAALRLIADLTAADTDLDNLLALIGPAIPALEK 250
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
924-1152 7.58e-03

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 40.66  E-value: 7.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  924 ERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGL----DEIIAKLTKEKKAL 999
Cdd:COG1340     1 SKTDELSSSLEELEEKIEELREEIEELKEKRDELNEELKELAEKRDELNAQVKELREEAQELrekrDELNEKVKELKEER 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1000 QEAHQQA------LDDLQAEEDKVNTLTKAKVKLEQQVDDLEG-------SLEQEKKVRMDLERAKRKLEgdlklTQESI 1066
Cdd:COG1340    81 DELNEKLnelreeLDELRKELAELNKAGGSIDKLRKEIERLEWrqqtevlSPEEEKELVEKIKELEKELE-----KAKKA 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1067 MDLENDKQQLDERLKKKDFELNALNARIedeQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEI 1146
Cdd:COG1340   156 LEKNEKLKELRAELKELRKEAEEIHKKI---KELAEEAQELHEEMIELYKEADELRKEADELHKEIVEAQEKADELHEEI 232

                  ....*.
gi 124302198 1147 SERLEE 1152
Cdd:COG1340   233 IELQKE 238
HMMR_N pfam15905
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ...
835-1083 7.75e-03

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.


Pssm-ID: 464932 [Multi-domain]  Cd Length: 329  Bit Score: 40.56  E-value: 7.75e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   835 KIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAeERCDQLIKNKIQ 914
Cdd:pfam15905   68 NLKESKDQKELEKEIRALVQERGEQDKRLQALEEELEKVEAKLNAAVREKTSLSASVASLEKQLLEL-TRVNELLKAKFS 146
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   915 LEAKVKEMN----ERLEDEEEMNA---ELTAKKRKLEDECSELKRD-------IDDLELTLAKVEKEKHATENKVKNLTE 980
Cdd:pfam15905  147 EDGTQKKMSslsmELMKLRNKLEAkmkEVMAKQEGMEGKLQVTQKNlehskgkVAQLEEKLVSTEKEKIEEKSETEKLLE 226
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198   981 EMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLK 1060
Cdd:pfam15905  227 YITELSCVSEQVEKYKLDIAQLEELLKEKNDEIESLKQSLEEKEQELSKQIKDLNEKCKLLESEKEELLREYEEKEQTLN 306
                          250       260
                   ....*....|....*....|...
gi 124302198  1061 LTQESIMDLENDKQQLDERLKKK 1083
Cdd:pfam15905  307 AELEELKEKLTLEEQEHQKLQQK 329
RecN COG0497
DNA repair ATPase RecN [Replication, recombination and repair];
1524-1793 8.47e-03

DNA repair ATPase RecN [Replication, recombination and repair];


Pssm-ID: 440263 [Multi-domain]  Cd Length: 555  Bit Score: 40.83  E-value: 8.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1524 HELEKVRKQLEaekmELQSALEEAEASLEheegkILRAQLEfnqikaEIErKLAEKDEEMEQ--AKRNHLRVVDSLQTSL 1601
Cdd:COG0497   165 RAWRALKKELE----ELRADEAERARELD-----LLRFQLE------ELE-AAALQPGEEEEleEERRRLSNAEKLREAL 228
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1602 daetrsrNEALRVkkkmegdLNEMEI----QLSHANRM---AAEAQKQVKSLQSLLKDTQIQLDDAVRanddlkeniaiv 1674
Cdd:COG0497   229 -------QEALEA-------LSGGEGgaldLLGQALRAlerLAEYDPSLAELAERLESALIELEEAAS------------ 282
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1675 errnnllqaeleELRAVVEQTErsrkLAEQELIETSERVQLLHS-------QNTSLINQKKKMDADLSQLQtEVEEAVQE 1747
Cdd:COG0497   283 ------------ELRRYLDSLE----FDPERLEEVEERLALLRRlarkygvTVEELLAYAEELRAELAELE-NSDERLEE 345
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 124302198 1748 CRNAEEKAKKAITDAammAEEL-KKEQDTSAHLErmkKNMEQTIKDL 1793
Cdd:COG0497   346 LEAELAEAEAELLEA---AEKLsAARKKAAKKLE---KAVTAELADL 386
ClpA COG0542
ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein ...
953-1066 8.48e-03

ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440308 [Multi-domain]  Cd Length: 836  Bit Score: 41.22  E-value: 8.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  953 DIDDLELTLAKVEKEKHATENkvknltEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVD 1032
Cdd:COG0542   412 ELDELERRLEQLEIEKEALKK------EQDEASFERLAELRDELAELEEELEALKARWEAEKELIEEIQELKEELEQRYG 485
                          90       100       110
                  ....*....|....*....|....*....|....
gi 124302198 1033 DLEgSLEQEkkvrmdLERAKRKLEGDLKLTQESI 1066
Cdd:COG0542   486 KIP-ELEKE------LAELEEELAELAPLLREEV 512
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
1525-1788 8.57e-03

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 41.19  E-value: 8.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1525 ELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQL------EFNQIKAEIERKLAEKDEEMEQAKRNhlRVVDSL- 1597
Cdd:PRK10929   31 ELEQAKAAKTPAQAEIVEALQSALNWLEERKGSLERAKQyqqvidNFPKLSAELRQQLNNERDEPRSVPPN--MSTDALe 108
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1598 ----QTS--LDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSllkdtqiqlddavranddlkENI 1671
Cdd:PRK10929  109 qeilQVSsqLLEKSRQAQQEQDRAREISDSLSQLPQQQTEARRQLNEIERRLQTLGT--------------------PNT 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1672 AIVERRNNLLQAELEELRAVVEQTERSRKLA--EQELIETseRVQLLHSQNTSLINQKKKMDADL-SQLQTEVEEAVQec 1748
Cdd:PRK10929  169 PLAQAQLTALQAESAALKALVDELELAQLSAnnRQELARL--RSELAKKRSQQLDAYLQALRNQLnSQRQREAERALE-- 244
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 124302198 1749 rNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQ 1788
Cdd:PRK10929  245 -STELLAEQSGDLPKSIVAQFKINRELSQALNQQAQRMDL 283
PRK12704 PRK12704
phosphodiesterase; Provisional
1528-1652 8.75e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 40.92  E-value: 8.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198 1528 KVRKQLEAEKMELQSALEEAEASLE-HEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETR 1606
Cdd:PRK12704   28 IAEAKIKEAEEEAKRILEEAKKEAEaIKKEALLEAKEEIHKLRNEFEKELRERRNELQKLEKRLLQKEENLDRKLELLEK 107
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 124302198 1607 SRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKD 1652
Cdd:PRK12704  108 REEELEKKEKELEQKQQELEKKEEELEELIEEQLQELERISGLTAE 153
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
835-1112 8.83e-03

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 41.10  E-value: 8.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  835 KIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNdlQLQVQAEQDNLADAEERCDQLIKNKIQ 914
Cdd:COG5185   266 RLEKLGENAESSKRLNENANNLIKQFENTKEKIAEYTKSIDIKKATESLEE--QLAAAEAEQELEESKRETETGIQNLTA 343
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  915 --------LEAKVKEMNERLE--DEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENK-VKNLTEEMA 983
Cdd:COG5185   344 eieqgqesLTENLEAIKEEIEniVGEVELSKSSEELDSFKDTIESTKESLDEIPQNQRGYAQEILATLEDtLKAADRQIE 423
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  984 GLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRmDLERAKRKLEGDLKLTQ 1063
Cdd:COG5185   424 ELQRQIEQATSSNEEVSKLLNELISELNKVMREADEESQSRLEEAYDEINRSVRSKKEDLNE-ELTQIESRVSTLKATLE 502
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 124302198 1064 ESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQ 1112
Cdd:COG5185   503 KLRAKLERQLEGVRSKLDQVAESLKDFMRARGYAHILALENLIPASELI 551
PRK00106 PRK00106
ribonuclease Y;
882-1058 9.03e-03

ribonuclease Y;


Pssm-ID: 178867 [Multi-domain]  Cd Length: 535  Bit Score: 41.01  E-value: 9.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  882 QEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNA---ELTAKKRKLEDECSELKRDIDDLE 958
Cdd:PRK00106   42 QEAVNLRGKAERDAEHIKKTAKRESKALKKELLLEAKEEARKYREEIEQEFKSerqELKQIESRLTERATSLDRKDENLS 121
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  959 LTLAKVEKEKHATENKVKNLTEEmaglDEIIAKLTKEKkalqEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSL 1038
Cdd:PRK00106  122 SKEKTLESKEQSLTDKSKHIDER----EEQVEKLEEQK----KAELERVAALSQAEAREIILAETENKLTHEIATRIREA 193
                         170       180
                  ....*....|....*....|....*.
gi 124302198 1039 EQEKKVRMD------LERAKRKLEGD 1058
Cdd:PRK00106  194 EREVKDRSDkmakdlLAQAMQRLAGE 219
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
844-1152 9.73e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 40.66  E-value: 9.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  844 EREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMN 923
Cdd:COG4372    56 QAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLE 135
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  924 ERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLE-----LTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKA 998
Cdd:COG4372   136 AQIAELQSEIAEREEELKELEEQLESLQEELAALEqelqaLSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRE 215
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124302198  999 LQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDE 1078
Cdd:COG4372   216 LAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKEIEELELAILVEKDTEEEELEIAALELEALEEAALEL 295
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 124302198 1079 RLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEE 1152
Cdd:COG4372   296 KLLALLLNLAALSLIGALEDALLAALLELAKKLELALAILLAELADLLQLLLVGLLDNDVLELLSKGAEAGVAD 369
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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