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Conserved domains on  [gi|164613607|gb|ABY64032|]
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NADH dehydrogenase subunit 4, partial (mitochondrion) [Topaza pella]

Protein Classification

proton-conducting transporter membrane subunit( domain architecture ID 1562513)

proton-conducting transporter membrane subunit such as NADH dehydrogenase subunit 2, 4, or N, which shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain

EC:  7.1.-.-
Gene Ontology:  GO:0005886

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Proton_antipo_M super family cl39059
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 1-213 5.89e-121

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


The actual alignment was detected with superfamily member MTH00124:

Pssm-ID: 476862 [Multi-domain]  Cd Length: 457  Bit Score: 351.42  E-value: 5.89e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607   1 AGSMLLAALLLKLGGYGIMRITLLTGPIPDALYYPFLSLALWGALMTSSICLRQTDLKSLIAYSSISHMGLVIAASMIQT 80
Cdd:MTH00124 226 AGSMVLAAILLKLGGYGIIRITLLLPPLSNTLHYPFLTLALWGALMTSLICLRQTDLKSLIAYSSVSHMGLVIAATMIQT 305

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607  81 HWSFSGAMILMISHGLTSSMLFCLANTNYERTHSRILILARGLQPLLPLMSTWWLLANLTNMALPPTTNLMAELTIMIAL 160
Cdd:MTH00124 306 PWSLSGAMILMIAHGLTSSMLFCLANTNYERTHSRTLLLTRGLQLLLPLMTTWWLLANLTNMALPPTINLMGELTIMTSL 385

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 164613607 161 FNWSPLTILMTGAATFLTASYTLFMFTTTQRGPLPTHITHMQNSTTREHLLMT 213
Cdd:MTH00124 386 FNWSPTTIILTGLATLITASYTLYMFLSTQRGTLPTHITTIQPTHTREHLLMT 438
 
Name Accession Description Interval E-value
ND4 MTH00124
NADH dehydrogenase subunit 4; Provisional
 1-213 5.89e-121

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214427 [Multi-domain]  Cd Length: 457  Bit Score: 351.42  E-value: 5.89e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607   1 AGSMLLAALLLKLGGYGIMRITLLTGPIPDALYYPFLSLALWGALMTSSICLRQTDLKSLIAYSSISHMGLVIAASMIQT 80
Cdd:MTH00124 226 AGSMVLAAILLKLGGYGIIRITLLLPPLSNTLHYPFLTLALWGALMTSLICLRQTDLKSLIAYSSVSHMGLVIAATMIQT 305

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607  81 HWSFSGAMILMISHGLTSSMLFCLANTNYERTHSRILILARGLQPLLPLMSTWWLLANLTNMALPPTTNLMAELTIMIAL 160
Cdd:MTH00124 306 PWSLSGAMILMIAHGLTSSMLFCLANTNYERTHSRTLLLTRGLQLLLPLMTTWWLLANLTNMALPPTINLMGELTIMTSL 385

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 164613607 161 FNWSPLTILMTGAATFLTASYTLFMFTTTQRGPLPTHITHMQNSTTREHLLMT 213
Cdd:MTH00124 386 FNWSPTTIILTGLATLITASYTLYMFLSTQRGTLPTHITTIQPTHTREHLLMT 438
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 1-172 1.10e-39

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 138.22  E-value: 1.10e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607    1 AGSMLLAALLLKLGGYGIMRITLLTGPIPDALYYPFLSLALWGALMTSSICLRQTDLKSLIAYSSISHMGLVIAASMIQT 80
Cdd:pfam00361 115 PVSALLAATLVKAGGYGLIRRSLLYLPSSPFIQQILLILAIISMLLGSLAALVQTDIKRLLAYSSISHMGYMLIALGAGT 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607   81 HWSFSGAMILMISHGLTSSMLFCLA-NTNYERTHSRILILARGLQPLLPLMSTWWLLANLTNMALPPTTNLMAELTIMIA 159
Cdd:pfam00361 195 IYGIQAAIFHLLTHGLFSAGLFLCAgSVIYRRVHTRNIRDYGGLAKTMPILALVFLVAMLSLAGLPPTAGFLGKFLILAA 274

                         170
                  ....*....|...
gi 164613607  160 LFNWSPLTILMTG 172
Cdd:pfam00361 275 AVAASWIFLVLAG 287
NuoM COG1008
NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH: ...
 14-212 6.49e-37

NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 4 (chain M) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440632 [Multi-domain]  Cd Length: 488  Bit Score: 134.82  E-value: 6.49e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607  14 GGYGIMRITLltgPI-PDALYY---PFLSLALWGALMTSSICLRQTDLKSLIAYSSISHMGLVIAASMIQTHWSFSGAMI 89
Cdd:COG1008  255 GGYGLLRFAL---PLfPEASAYfapLLAALGVIGIIYGALVALAQTDLKRLIAYSSVSHMGFVLLGIFALNPLGLQGAVL 331

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607  90 LMISHGLTSSMLFCLANTNYERTHSRILILARGLQPLLPLMSTWWLLANLTNMALPPTTNLMAELTIMIALFNWSPLTIL 169
Cdd:COG1008  332 QMVSHGLITAALFLLVGVLYDRTHTRDIADLGGLAKRMPVLAALFLLAALASLGLPGTSGFVGEFLVLLGAFQVNPWLAI 411

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 164613607 170 MTGAATFLTASYTLFMFTTTQRGPLPTHITHMQNSTTREHLLM 212
Cdd:COG1008  412 LAALGLILTAAYLLWMYQRVFFGPLKEELAELPDLNPRELAVL 454
NDH_I_M TIGR01972
proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th ...
 1-208 6.16e-32

proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th (based on E. coli) structural gene, M, of bacterial NADH dehydrogenase I, as well as chain 4 of the corresponding mitochondrial complex I and of the chloroplast NAD(P)H dehydrogenase complex. [Energy metabolism, Electron transport]


Pssm-ID: 273903 [Multi-domain]  Cd Length: 481  Bit Score: 121.20  E-value: 6.16e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607    1 AGSMLLAALLLKLGGYGIMRITLLTGPIPDALYYPFL-SLALWGALMTSSICLRQTDLKSLIAYSSISHMGLVIAASMIQ 79
Cdd:TIGR01972 236 AGSVILAGVLLKMGTYGFLRFNLPLFPDASLYFAPVLaALGVIAIIYGALIALAQTDIKRLIAYSSISHMGFVLLGIFSF 315

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607   80 THWSFSGAMILMISHGLTSSMLFCLANTNYERTHSRILILARGLQPLLPLMSTWWLLANLTNMALPPTTNLMAELTIMIA 159
Cdd:TIGR01972 316 NELGISGAVFQMISHGLITAALFLLVGVLYERAHTRDIAKYGGLANKMPVLAAFFMLFAMASLGLPGTSGFVGEFLILLG 395

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 164613607  160 LFNWSPLTILMTGAATFLTASYTLFMFTTTQRGPLP-THITHMQNSTTRE 208
Cdd:TIGR01972 396 SFKVNPVVAFLAALGIVLAAAYMLTLYKRVFFGELSnPEVAEFPDLNGRE 445
 
Name Accession Description Interval E-value
ND4 MTH00124
NADH dehydrogenase subunit 4; Provisional
 1-213 5.89e-121

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214427 [Multi-domain]  Cd Length: 457  Bit Score: 351.42  E-value: 5.89e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607   1 AGSMLLAALLLKLGGYGIMRITLLTGPIPDALYYPFLSLALWGALMTSSICLRQTDLKSLIAYSSISHMGLVIAASMIQT 80
Cdd:MTH00124 226 AGSMVLAAILLKLGGYGIIRITLLLPPLSNTLHYPFLTLALWGALMTSLICLRQTDLKSLIAYSSVSHMGLVIAATMIQT 305

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607  81 HWSFSGAMILMISHGLTSSMLFCLANTNYERTHSRILILARGLQPLLPLMSTWWLLANLTNMALPPTTNLMAELTIMIAL 160
Cdd:MTH00124 306 PWSLSGAMILMIAHGLTSSMLFCLANTNYERTHSRTLLLTRGLQLLLPLMTTWWLLANLTNMALPPTINLMGELTIMTSL 385

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 164613607 161 FNWSPLTILMTGAATFLTASYTLFMFTTTQRGPLPTHITHMQNSTTREHLLMT 213
Cdd:MTH00124 386 FNWSPTTIILTGLATLITASYTLYMFLSTQRGTLPTHITTIQPTHTREHLLMT 438
ND4 MTH00068
NADH dehydrogenase subunit 4; Provisional
 1-213 1.22e-102

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214417 [Multi-domain]  Cd Length: 458  Bit Score: 304.53  E-value: 1.22e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607   1 AGSMLLAALLLKLGGYGIMRITLLTGPIPDALYYPFLSLALWGALMTSSICLRQTDLKSLIAYSSISHMGLVIAASMIQT 80
Cdd:MTH00068 226 AGSMILAAVLLKLGGYGILRISILLTPLSKELSYPFIILALWGVLMTSLICLRQTDLKSLIAYSSVSHMGLVIAAALIQT 305

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607  81 HWSFSGAMILMISHGLTSSMLFCLANTNYERTHSRILILARGLQPLLPLMSTWWLLANLTNMALPPTTNLMAELTIMIAL 160
Cdd:MTH00068 306 PWSFSGAIILMISHGLTSSALFCLANTNYERTHSRTLLLLRGAQTILPLMATWWLLSNLSNMALPPSPNLWGELTIMVSL 385

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 164613607 161 FNWSPLTILMTGAATFLTASYTLFMFTTTQRGPLPTHITHMQNSTTREHLLMT 213
Cdd:MTH00068 386 FNWSNWTILITGLGTLITAAYTLYMFLMTQRGPLPNHLKTLFPTYTREHLLLA 438
ND4 MTH00110
NADH dehydrogenase subunit 4; Provisional
 1-213 4.04e-100

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 177172 [Multi-domain]  Cd Length: 459  Bit Score: 298.34  E-value: 4.04e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607   1 AGSMLLAALLLKLGGYGIMRITLLTGPIPDALYYPFLSLALWGALMTSSICLRQTDLKSLIAYSSISHMGLVIAASMIQT 80
Cdd:MTH00110 226 AGSMVLAAILLKLGGYGMMRITIILNPLTEFMAYPFLMLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIVAILIQT 305

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607  81 HWSFSGAMILMISHGLTSSMLFCLANTNYERTHSRILILARGLQPLLPLMSTWWLLANLTNMALPPTTNLMAELTIMIAL 160
Cdd:MTH00110 306 PWSFMGATALMIAHGLTSSMLFCLANSNYERIHSRTMILARGLQTLLPLMATWWLLASLTNLALPPTINLIGELFVIMSS 385

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 164613607 161 FNWSPLTILMTGAATFLTASYTLFMFTTTQRGPLPTHITHMQNSTTREHLLMT 213
Cdd:MTH00110 386 FSWSNITIILMGLNMLITALYSLYMLITTQRGKLTHHINNIKPSFTRENTLMA 438
ND4 MTH00127
NADH dehydrogenase subunit 4; Provisional
 1-213 1.13e-81

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 177186 [Multi-domain]  Cd Length: 459  Bit Score: 251.03  E-value: 1.13e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607   1 AGSMLLAALLLKLGGYGIMRITLLTGPIPDALYYPFLSLALWGALMTSSICLRQTDLKSLIAYSSISHMGLVIAASMIQT 80
Cdd:MTH00127 227 AGSMVLAAVLLKLGGYGMMRMMVMLDPLTKELSYPFIILALWGIIMTGSICLRQTDLKSLIAYSSVSHMGLVAGGILIQT 306

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607  81 HWSFSGAMILMISHGLTSSMLFCLANTNYERTHSRILILARGLQPLLPLMSTWWLLANLTNMALPPTTNLMAELTIMIAL 160
Cdd:MTH00127 307 PWGFTGALILMIAHGLTSSALFCLANTNYERTHSRTMLLARGLQMILPLMATWWFIASLANLALPPLPNLMGELMIITSL 386

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 164613607 161 FNWSPLTILMTGAATFLTASYTLFMFTTTQRGPLPTHITHMQNSTTREHLLMT 213
Cdd:MTH00127 387 FNWSPWTLALTGLGTLITAGYSLYMFLMTQRGPLPDHIIALNPSHTREHLLMA 439
ND4 MTH00206
NADH dehydrogenase subunit 4; Provisional
 1-213 1.59e-77

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214458 [Multi-domain]  Cd Length: 450  Bit Score: 240.23  E-value: 1.59e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607   1 AGSMLLAALLLKLGGYGIMRITLLTGPIPDALYYPFLSLALWGALMTSSICLRQTDLKSLIAYSSISHMGLVIAASMIQT 80
Cdd:MTH00206 222 AGSMVLAGVLLKLGGYGMMRIILILGPSTKLSSYFFIILGLWGSIMTSSICLRQTDLKSLIAYSSVSHMSLVTAGILSGS 301

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607  81 HWSFSGAMILMISHGLTSSMLFCLANTNYERTHSRILILARGLQPLLPLMSTWWLLANLTNMALPPTTNLMAELTIMIAL 160
Cdd:MTH00206 302 PWGFKGALLLMIAHGLVSSALFCLANLLYERSHTRTILGNRGLQMILPLLSFWWLLFFLANLGLPPFPNLFGELLIITSL 381

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 164613607 161 FNWSPLTILMTGAATFLTASYTLFMFTTTQRGPLPTHITHMQNSTTREHLLMT 213
Cdd:MTH00206 382 FSWSNFTLPLLGLGFLFTAIYSLYMFVMTQHGKTPNHLLSLSPSSTREHLLLF 434
ND4 MTH00044
NADH dehydrogenase subunit 4; Validated
 1-213 4.64e-64

NADH dehydrogenase subunit 4; Validated


Pssm-ID: 214411 [Multi-domain]  Cd Length: 458  Bit Score: 205.59  E-value: 4.64e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607   1 AGSMLLAALLLKLGGYGIMR-ITLLTGPIPDALYYPFLSLALWGALMTSSICLRQTDLKSLIAYSSISHMGLVIAASMIQ 79
Cdd:MTH00044 227 AGSMILAAILLKLGGYGLIRlINLFSLPSANNISFILIVFCCWGALITSIICLRQTDLKALIAYSSVGHMSLVAAGIFSG 306

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607  80 THWSFSGAMILMISHGLTSSMLFCLANTNYERTHSRILILARGLQPLLPLMSTWWLLANLTNMALPPTTNLMAELTIMIA 159
Cdd:MTH00044 307 TNWGINGALILMIAHGLVSSALFCLANILYERSGTRTLSITRGFKLITPLLPLWWLIFCAANLGLPPLPNLIGELLIISS 386

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 164613607 160 LFNWSPLTILMTGAATFLTASYTLFMFTTTQRGPLPTHITHMQNSTTREHLLMT 213
Cdd:MTH00044 387 IISWSILSFPIIGLATVFGAIYSLLIYQLTNSGSFPSWISNVSPISSREHLLIF 440
ND4 MTH00163
NADH dehydrogenase subunit 4; Provisional
 14-212 7.94e-56

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214443 [Multi-domain]  Cd Length: 445  Bit Score: 183.82  E-value: 7.94e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607  14 GGYGIMRITLLTGPIPDALYYPFLSLALWGALMTSSICLRQTDLKSLIAYSSISHMGLVIAASMIQTHWSFSGAMILMIS 93
Cdd:MTH00163 227 GGYGLLRVMSFFSKLGLKFNYIWISISLVGGVIVSLICLRQVDLKSLIAYSSVAHMGLVLGGLMTFSYWGLMGSLLMMIG 306

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607  94 HGLTSSMLFCLANTNYERTHSRILILARGLQPLLPLMSTWWLLANLTNMALPPTTNLMAELTIMIALFNWSPLTILMTGA 173
Cdd:MTH00163 307 HGLCSSGLFCLANIIYERLGSRSLLINKGLLNFMPSMSLWWFLLSSSNMAAPPSLNLLGEISLINSLISWSKLSMIFLML 386

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 164613607 174 ATFLTASYTLFMFTTTQRGPLPTHITHMQNSTTREHLLM 212
Cdd:MTH00163 387 LSFFSAAYSLYLYSYSQHGKYYSGLYSCSSGKVREYLLL 425
ND4 MTH00150
NADH dehydrogenase subunit 4; Provisional
 1-212 3.65e-54

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214435 [Multi-domain]  Cd Length: 417  Bit Score: 178.88  E-value: 3.65e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607   1 AGSMLLAALLLKLGGYGIMRITLLTGPIPDALYYPFLSLALWGALMTSSICLRQTDLKSLIAYSSISHMGLVIAASMIQT 80
Cdd:MTH00150 185 AGSMILAGILLKLGGYGILRMMMVFSLSSSSFSIFLISLSLWGGVLTSLICLRQSDVKSLIAYSSVGHMSLVLAGVLSNT 264

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607  81 HWSFSGAMILMISHGLTSSMLFCLANTNYERTHSRILILARGLQPLLPLMSTWWLLANLTNMALPPTTNLMAELTIMIAL 160
Cdd:MTH00150 265 SWGWVGALIMMVSHGFCSSGLFCLANYTYEKVHSRSLFLSKGMLMLYPSLSLWWFLFCIINMAAPPSLNLLSEIMIFPSL 344

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 164613607 161 FNWSPLTILMTGAATFLTASYTLFMFTTTQRGPLPTHITHMQNSTTREHLLM 212
Cdd:MTH00150 345 ISYSPWFFVPLGLMVFLSGLYSLYLYTSIQHGGSSSFLKPFNELKSSEMLLL 396
ND4 MTH00014
NADH dehydrogenase subunit 4; Validated
 1-213 1.54e-50

NADH dehydrogenase subunit 4; Validated


Pssm-ID: 214399 [Multi-domain]  Cd Length: 452  Bit Score: 170.31  E-value: 1.54e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607   1 AGSMLLAALLLKLGGYGIMRITLLTGPIPDALYYPFLSLALWGALMTSSICLRQTDLKSLIAYSSISHMGLVIAASMIQT 80
Cdd:MTH00014 220 AGSMILAGILLKLGGYGLLRMSSLFMHINKSLSAPFSSISLVGAVITSLICIRQPDLKSLIAYSSVGHMGLMTAGIMSNT 299

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607  81 HWSFSGAMILMISHGLTSSMLFCLANTNYERTHSRILILARGLQPLLPLMSTWWLLANLTNMALPPTTNLMAELTIMIAL 160
Cdd:MTH00014 300 SWGWQGALAMMIAHGLCSSALFALANMTYETTHTRSLFLTKGLLSLFPTMTMWWFLLSAANMAAPPSINLLSEIMLLTSI 379

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 164613607 161 FNWSPLTILMTGAATFLTASYTLFMFTTTQRGPLPTHITHMQNSTTREHLLMT 213
Cdd:MTH00014 380 LSSSLSTAILLAITSFLAAAYSLFLYTSTQHGSPPSFMNPLNLFTPRNHTLMT 432
ND4 MTH00205
NADH dehydrogenase subunit 4; Provisional
 1-212 1.27e-48

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214457 [Multi-domain]  Cd Length: 448  Bit Score: 165.15  E-value: 1.27e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607   1 AGSMLLAALLLKLGGYGIMRITLLTGPIPDALYYPFLSLALWGALMTSSICLRQTDLKSLIAYSSISHMGLVIAASMIQT 80
Cdd:MTH00205 218 SGSMILAGVLLKLGGYGLIRITSMLYKLNSNFSELFFSISLWGGVMTGMICLRQVDLKSLIAYSSVGHMGLMVVGVFSNT 297

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607  81 HWSFSGAMILMISHGLTSSMLFCLANTNYERTHSRILILARGLQPLLPLMSTWWLLANLTNMALPPTTNLMAELTIMIAL 160
Cdd:MTH00205 298 SWGMNGAIIMMVAHGLCSSGMFALANVNYERTNSRSMLMNKGVLNTFPFLVLMWFLLISCNMAAPPSLNLASEILLIMSL 377

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 164613607 161 FNWSPLTILMTGAATFLTASYTLFMFTTTQRGPLPTHITHMQNSTTREHLLM 212
Cdd:MTH00205 378 LSSSKISGIPLSLISFLSGAYSLYLYSQSQHGKVSSQISSFLAISEREYYIL 429
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 1-172 1.10e-39

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 138.22  E-value: 1.10e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607    1 AGSMLLAALLLKLGGYGIMRITLLTGPIPDALYYPFLSLALWGALMTSSICLRQTDLKSLIAYSSISHMGLVIAASMIQT 80
Cdd:pfam00361 115 PVSALLAATLVKAGGYGLIRRSLLYLPSSPFIQQILLILAIISMLLGSLAALVQTDIKRLLAYSSISHMGYMLIALGAGT 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607   81 HWSFSGAMILMISHGLTSSMLFCLA-NTNYERTHSRILILARGLQPLLPLMSTWWLLANLTNMALPPTTNLMAELTIMIA 159
Cdd:pfam00361 195 IYGIQAAIFHLLTHGLFSAGLFLCAgSVIYRRVHTRNIRDYGGLAKTMPILALVFLVAMLSLAGLPPTAGFLGKFLILAA 274

                         170
                  ....*....|...
gi 164613607  160 LFNWSPLTILMTG 172
Cdd:pfam00361 275 AVAASWIFLVLAG 287
NuoM COG1008
NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH: ...
 14-212 6.49e-37

NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 4 (chain M) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440632 [Multi-domain]  Cd Length: 488  Bit Score: 134.82  E-value: 6.49e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607  14 GGYGIMRITLltgPI-PDALYY---PFLSLALWGALMTSSICLRQTDLKSLIAYSSISHMGLVIAASMIQTHWSFSGAMI 89
Cdd:COG1008  255 GGYGLLRFAL---PLfPEASAYfapLLAALGVIGIIYGALVALAQTDLKRLIAYSSVSHMGFVLLGIFALNPLGLQGAVL 331

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607  90 LMISHGLTSSMLFCLANTNYERTHSRILILARGLQPLLPLMSTWWLLANLTNMALPPTTNLMAELTIMIALFNWSPLTIL 169
Cdd:COG1008  332 QMVSHGLITAALFLLVGVLYDRTHTRDIADLGGLAKRMPVLAALFLLAALASLGLPGTSGFVGEFLVLLGAFQVNPWLAI 411

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 164613607 170 MTGAATFLTASYTLFMFTTTQRGPLPTHITHMQNSTTREHLLM 212
Cdd:COG1008  412 LAALGLILTAAYLLWMYQRVFFGPLKEELAELPDLNPRELAVL 454
NDH_I_M TIGR01972
proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th ...
 1-208 6.16e-32

proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th (based on E. coli) structural gene, M, of bacterial NADH dehydrogenase I, as well as chain 4 of the corresponding mitochondrial complex I and of the chloroplast NAD(P)H dehydrogenase complex. [Energy metabolism, Electron transport]


Pssm-ID: 273903 [Multi-domain]  Cd Length: 481  Bit Score: 121.20  E-value: 6.16e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607    1 AGSMLLAALLLKLGGYGIMRITLLTGPIPDALYYPFL-SLALWGALMTSSICLRQTDLKSLIAYSSISHMGLVIAASMIQ 79
Cdd:TIGR01972 236 AGSVILAGVLLKMGTYGFLRFNLPLFPDASLYFAPVLaALGVIAIIYGALIALAQTDIKRLIAYSSISHMGFVLLGIFSF 315

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607   80 THWSFSGAMILMISHGLTSSMLFCLANTNYERTHSRILILARGLQPLLPLMSTWWLLANLTNMALPPTTNLMAELTIMIA 159
Cdd:TIGR01972 316 NELGISGAVFQMISHGLITAALFLLVGVLYERAHTRDIAKYGGLANKMPVLAAFFMLFAMASLGLPGTSGFVGEFLILLG 395

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 164613607  160 LFNWSPLTILMTGAATFLTASYTLFMFTTTQRGPLP-THITHMQNSTTRE 208
Cdd:TIGR01972 396 SFKVNPVVAFLAALGIVLAAAYMLTLYKRVFFGELSnPEVAEFPDLNGRE 445
PRK05846 PRK05846
NADH:ubiquinone oxidoreductase subunit M; Reviewed
 1-212 6.49e-29

NADH:ubiquinone oxidoreductase subunit M; Reviewed


Pssm-ID: 235622 [Multi-domain]  Cd Length: 497  Bit Score: 112.99  E-value: 6.49e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607   1 AGSMLLAALLLKLGGYGIMRITLltgPI-PDA---LYYPFLSLALWGALMTSSICLRQTDLKSLIAYSSISHMGLVIAAS 76
Cdd:PRK05846 244 AGSVLLAGILLKMGAYGLLRFSL---PLfPDAsheFAPIIITLGVIAIIYGALVALAQTDIKKLIAYSSISHMGFVTLGI 320

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607  77 MIQTHWSFSGAMILMISHGLTSSMLFCLANTNYERTHSRILILARGLQPLLPLMSTWWLLANLTNMALPPTTNLMAELTI 156
Cdd:PRK05846 321 FAGNQLGIQGAIFQMISHGLSSAALFLLVGVLYDRLHTRDIADYGGLAKVMPVLAAFFLFFAMASLGLPGTSGFVGEFLI 400

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 164613607 157 MIALFNWSPLTILMTGAATFLTASYTLFMFTTTQRGPLPTHITHMQNSTTREHLLM 212
Cdd:PRK05846 401 LLGSFQVNPVIAFIATTGLILAAVYSLWLYQRVMFGPVKNEVAKLKDLNGRELLIL 456
ND4 MTH00204
NADH dehydrogenase subunit 4; Provisional
 1-186 8.42e-27

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 164750 [Multi-domain]  Cd Length: 485  Bit Score: 107.07  E-value: 8.42e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607   1 AGSMLLAALLLKLGGYGIMRITLLTGPIPDALYYP---FLSL--ALWGALMTSsiclRQTDLKSLIAYSSISHMGLVIAA 75
Cdd:MTH00204 242 AGSVILAGILLKLGGYGFLRFSWPLFPAASEYFAPlivMLSViaVIYGSLTTC----RQVDFKRLIAYSSVAHMGLVPLG 317

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607  76 SMIQTHWSFSGAMILMISHGLTSSMLFCLANTNYERTHSRILILARGLQPLLPLMSTWWLLANLTNMALPPTTNLMAELT 155
Cdd:MTH00204 318 LFTHTIEGLVAAVFLMLAHGFVSSALFIAVTFLYERHHTRLIKYYRGLTLTMPLFVIIMLVLSLANMGFPLSCNFVGEFF 397

                        170       180       190
                 ....*....|....*....|....*....|.
gi 164613607 156 IMIALFNWSPLTILMTGAATFLTASYTLFMF 186
Cdd:MTH00204 398 SLLAAFEYSLGLGVLVTSGMVWSAAYSLYLY 428
ND4 MTH00217
NADH dehydrogenase subunit 4; Provisional
 1-186 8.14e-26

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214462 [Multi-domain]  Cd Length: 482  Bit Score: 104.36  E-value: 8.14e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607   1 AGSMLLAALLLKLGGYGIMRITLLTGPIPDALYYPF-LSLALWGALMTSSICLRQTDLKSLIAYSSISHMGLVIAASMIQ 79
Cdd:MTH00217 239 AGSVILAGVLLKLGGYGFIRFSWPLLPEASEYFSPLiQTLSLLAIIYGSLTTCRQVDLKRIIAYSSVAHMGLVTLGIFSH 318

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607  80 THWSFSGAMILMISHGLTSSMLFCLANTNYERTHSRILILARGLQPLLPLMSTWWLLANLTNMALPPTTNLMAELTIMIA 159
Cdd:MTH00217 319 TIQGLVAAIFLMLAHGLVSSALFIAVTFLYERHHTRLIKYYRGMVITMPLFGILMLLLVLANASIPLSCNFVGEFLSLLA 398

                        170       180
                 ....*....|....*....|....*..
gi 164613607 160 LFNWSPLTILMTGAATFLTASYTLFMF 186
Cdd:MTH00217 399 AFEYSYIVGVLASLGMVLSAGYSIYLY 425
ND4 MTH00226
NADH dehydrogenase subunit 4; Provisional
 1-208 1.21e-24

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214466 [Multi-domain]  Cd Length: 505  Bit Score: 101.15  E-value: 1.21e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607   1 AGSMLLAALLLKLGGYGIMRITLLTGPIPDALYYP-FLSLALWGALMTSSICLRQTDLKSLIAYSSISHMGLVIAASMIQ 79
Cdd:MTH00226 263 AGSVLLAGILLKLGGYGLVRLSWPILPLGAQNLAPaVIAMGIVGIVYGSFATCRQIDVKRLVAYSSVAHMGLVSITLVTH 342

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607  80 THWSFSGAMILMISHGLTSSMLFCLANTNYERTHSRILILARGLQPLLPLMSTWWLLANLTNMALPPTTNLMAELTIMIA 159
Cdd:MTH00226 343 DIIGLTGSIFIMLAHGIVSSLLFILVTILYDRHHTRLIKYYRGLSITMPIWGTIMIVTSLANVAVPPSGNFIGEYLSILS 422

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 164613607 160 LFNWSPLTILMTGAATFLTASYTLFMFTTTQRGPLPTHITHMQNSTTRE 208
Cdd:MTH00226 423 SFNWNPIIGVFVCSGVILSAVYSFYFANRVTFGAPGNLITFARDVNRRE 471
PRK06473 PRK06473
NADH-quinone oxidoreductase subunit M;
14-201 9.33e-20

NADH-quinone oxidoreductase subunit M;


Pssm-ID: 235810 [Multi-domain]  Cd Length: 500  Bit Score: 87.06  E-value: 9.33e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607  14 GGYGIMRITLltGPIPDALYYPFLSLALWGA---LMTSSICLRQTDLKSLIAYSSISHMGLVIAASMIQTHWSFSGAMIL 90
Cdd:PRK06473 251 GTYGLLRFGV--GLFPEAWVYLAPWLATWAVvsvLYGASCAIAQKDMKKMVAYSSIGHMGYILLAAAAATPLSILAAVFQ 328

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607  91 MISHGLTSSMLFCLANTNYERTHSRILILARGL---QPLLPLMSTWWLLANLTNMALPPTTNLMAELTIMIALFNWSPLT 167
Cdd:PRK06473 329 MISHGLISALLFLLVGVVYKKTGSRDVDVLRGLlnpERGLPITGSLMILGVMASAGIPGMVGFIAEFLVFRGSFPIFPVQ 408

                        170       180       190
                 ....*....|....*....|....*....|....
gi 164613607 168 ILMTGAATFLTASYTLFMFTTTQRGPLPTHITHM 201
Cdd:PRK06473 409 TLLCMIGTGLTAVYFLLLVNRVFFGRLTAELSNL 442
PRK12561 PRK12561
NAD(P)H-quinone oxidoreductase subunit 4; Provisional
 2-195 6.59e-19

NAD(P)H-quinone oxidoreductase subunit 4; Provisional


Pssm-ID: 237137 [Multi-domain]  Cd Length: 504  Bit Score: 84.70  E-value: 6.59e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607   2 GSMLLAALLLKLGGYGIMRITLltGPIPDALYY--PFLSL-----ALWGALMTssicLRQTDLKSLIAYSSISHMGLVIA 74
Cdd:PRK12561 219 VSMILAGVLLKMGGYALIRFNV--QMLPDAHVYfaPALAIlgvvnIIYGALNA----FAQDNVKRRLAYSSVSHMGFVLL 292

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607  75 ASMIQTHWSFSGAMILMISHGLTSSMLFCLANTNYERTHSRILILARGLQPLLPLMSTWWLLANLTNMALPPTTNLMAEL 154
Cdd:PRK12561 293 GIAAFTDLGISGAMLQMISHGLIAAALFFLTGVTYERTHTLSIPNMGGLAKVMPKTFALFTASSMASLALPGMSGFVSEL 372

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 164613607 155 TIMIALFN---WSPL----TILMTGAATFLTASYTLFM----FTTTQRGPLP 195
Cdd:PRK12561 373 TVFLGITSsdvYSSTfrtiTILLAAVGLILTPIYLLSMlrrvFYGPRSELLP 424
HyfB COG0651
Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy ...
 14-177 4.52e-18

Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 440416 [Multi-domain]  Cd Length: 430  Bit Score: 82.12  E-value: 4.52e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607  14 GGYGIMRITLLTGPIPDALY--YPFLSLALWGALMTSSICLRQTDLKSLIAYSSISHMGLVIAASMIQTHWSFSGAMILM 91
Cdd:COG0651  251 GVYAILRVLTLLFGADPALFlgTLLLVLGLLTMLVGALGALAQRDLKRLLAYSSVSQIGYILLGLGLGTPLGLAGALFHL 330

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607  92 ISHGLTSSMLFCLANTNYERTHSRILILARGLQPLLPLMSTWWLLANLTNMALPPTTNLMAELTIMIALFN----WSPLT 167
Cdd:COG0651  331 LNHALAKALLFLAAGAIERATGTRDLDKLGGLGKRMPLTAAAFLIGALALAGLPPLSGFVSKWLLLQAALEagawLLAAV 410

                        170
                 ....*....|
gi 164613607 168 ILMTGAATFL 177
Cdd:COG0651  411 LLLSSLLTLA 420
PRK02546 PRK02546
NAD(P)H-quinone oxidoreductase subunit 4; Provisional
 14-203 2.69e-16

NAD(P)H-quinone oxidoreductase subunit 4; Provisional


Pssm-ID: 235050 [Multi-domain]  Cd Length: 525  Bit Score: 77.05  E-value: 2.69e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607  14 GGYGIMRITLLTGPIPDALYYPFL-SLALWGALMTSSICLRQTDLKSLIAYSSISHMGLVIAASMIQTHWSFSGAMILMI 92
Cdd:PRK02546 259 GGYALLRMNAGMLPDAHAQFAPLLiVLGVVNIIYAALTSFAQRNLKRKIAYSSISHMGFVLIGIGSFTDLGTSGAMLQMI 338

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607  93 SHGLTSSMLFCLANTNYERTHSRILILARGLQPLLPLMSTWWLLANLTNMALPPTTNLMAELTIMIALFN----WSPLTI 168
Cdd:PRK02546 339 SHGLIGASLFFLVGATYDRTHTLMLDEMGGVGQKMRKMFAMWTACSLASLALPGMSGFVAELMVFVGFATsdayTLPFRV 418

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 164613607 169 LMTGAATF---LTASYTLFMFTTTQRGPLPTHITHMQN 203
Cdd:PRK02546 419 VVVFLAAVgviLTPIYLLSMLREIFFGPENKELVSHEK 456
ND4 MTH00094
NADH dehydrogenase subunit 4; Provisional
 2-187 7.88e-16

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 177157 [Multi-domain]  Cd Length: 403  Bit Score: 75.33  E-value: 7.88e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607   2 GSMLLAALLLKLGGYGIMRITLLTGPIpdaLYYPFLSLALWGALMTSSICLRQTDLKSLIAYSSISHMGLVIAASMIQTH 81
Cdd:MTH00094 185 ASMLLAGLLLKLGTAGFLRILGSLNFV---YNNFWIIFSLLGMILSSFCCVFQSDSKSLAAYSSVTHMSFLLLSLVYMSM 261

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607  82 WSFSGAMILMISHGLTSSMLFCLANTNYERTHSRILILARGLQPLLPLMSTWWLLANLTNMALPPTTNLMAELTIMIALF 161
Cdd:MTH00094 262 SGKLSGLMMMLAHGYTSTLMFYLIGEFYHISKSRLIYFMNSFFSSSMFFGLIFSLVFLSNSGVPPSLSFFSEFLIISNSF 341

                        170       180
                 ....*....|....*....|....*.
gi 164613607 162 NWSPLTILMTGAATFLTASYTLFMFT 187
Cdd:MTH00094 342 MKNKFSFFFIFFYFLVSFYYSLFLIV 367
ndhD CHL00011
NADH dehydrogenase subunit 4
 14-156 1.05e-15

NADH dehydrogenase subunit 4


Pssm-ID: 176954 [Multi-domain]  Cd Length: 498  Bit Score: 75.37  E-value: 1.05e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607  14 GGYGIMRITLLTGPIPDALYYPFLslALWGALM---TSSICLRQTDLKSLIAYSSISHMGLVIAASMIQTHWSFSGAMIL 90
Cdd:CHL00011 257 GAYGLIRINMELLPHAHSIFSPWL--VIVGAIQiiyAASTSLGQRNLKKRIAYSSVSHMGFIIIGIGSITDTGLNGAILQ 334

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 164613607  91 MISHGLTSSMLFCLANTNYERTHSRILILARGLQPLLPLMSTWWLLANLTNMALPPTTNLMAELTI 156
Cdd:CHL00011 335 IISHGFIGAALFFLAGTSYDRIRLVYLDEMGGIAIPMPKIFTMFSSFSMASLALPGMSGFVAELIV 400
PRK07363 PRK07363
NADH-quinone oxidoreductase subunit M;
14-197 4.25e-15

NADH-quinone oxidoreductase subunit M;


Pssm-ID: 180945 [Multi-domain]  Cd Length: 501  Bit Score: 73.59  E-value: 4.25e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607  14 GGYGIMRITLLTGPIPDALYYPflSLALWGA---LMTSSICLRQTDLKSLIAYSSISHMGLVIAASMIQTHWSFSGAMIL 90
Cdd:PRK07363 251 GTYGLLRFGLQLFPQTWSLVAP--GLAIIGTisvIYGALSAIAQKDIKRMVAYSSIGHMGYILVAAAAGTQLSLLGAVAQ 328

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607  91 MISHGLTSSMLFCLANTNYERTHSRILILARGL-QPL--LPLMSTWWLLANLTNMALPPTTNLMAELTIMIALFNWSPLT 167
Cdd:PRK07363 329 MISHGLILALLFHLVGIVERKVGTRDLDVLNGLmNPIrgLPLTSALLVLAGMASAGIPGLVGFVAEFIVFQGSFSTFPIP 408

                        170       180       190
                 ....*....|....*....|....*....|
gi 164613607 168 ILMTGAATFLTASYTLFMFTTTQRGPLPTH 197
Cdd:PRK07363 409 TLLCIVASGLTAVYFVILLNRTCFGRLDNK 438
PRK12667 PRK12667
putative monovalent cation/H+ antiporter subunit D; Reviewed
 14-185 1.43e-11

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 237167 [Multi-domain]  Cd Length: 520  Bit Score: 63.07  E-value: 1.43e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607  14 GGYGIMRI-------TLLTGPIPDALYYPFLSLALWGALMTSSICLRQTDLKSLIAYSSISHMGLVIAASMIQTHWSFSG 86
Cdd:PRK12667 269 GAYAIIRFlytifgiSPSLIDFRAALSPILIILGAVSAIIGALMMVVQKDVKRLLAYSTISHMGYIFMGIGIGTQLGLAA 348

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607  87 AMILMISHGLTSSMLFCLANTNYERTHSRILILARGLQPLLPLMSTWWLLANLTNMALPPTTNLMAELTIMIALFNWSPL 166
Cdd:PRK12667 349 ALFHIINHAIAKSLLFLASGVFIHAAGTRDIDELAGLGRKMPIASFAFLIGALSLVGIPPLNGFFSKLLLFNALLESGFY 428

                        170       180
                 ....*....|....*....|..
gi 164613607 167 T---ILMTGAATFLTASYTLFM 185
Cdd:PRK12667 429 LpalVLLIASAISLVGYFRAWY 450
PRK06458 PRK06458
hydrogenase 4 subunit F; Validated
 16-168 4.38e-09

hydrogenase 4 subunit F; Validated


Pssm-ID: 235805 [Multi-domain]  Cd Length: 490  Bit Score: 55.71  E-value: 4.38e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607  16 YGIMRITLLT--GPIPDALYYPFLSLALWGALMTSSICLRQTDLKSLIAYSSISHMGLVIAASMIQTHWSFSGAMILMIS 93
Cdd:PRK06458 262 YAVLRYYILIdaAIGSDFPGRLLLIFGLLSVLVAAFFLLRQRDIKRLFAYSSIEHMGLIAFALGIGGPLGIFAALLHMLN 341

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 164613607  94 HGLTSSMLFCLANTNYERTHSRILILARGLQPLLPLMSTWWLLANLTNMALPPTTNLMAELTIMIALFNWSPLTI 168
Cdd:PRK06458 342 HSLTKSAIFFASGNVLQKYGTRDINVIRGLLKVSPLTGWGLMLGALAIAGMPPFGVFISEFLILTAGLARGPLLI 416
PRK12647 PRK12647
putative monovalent cation/H+ antiporter subunit A; Reviewed
 36-176 9.31e-09

putative monovalent cation/H+ antiporter subunit A; Reviewed


Pssm-ID: 237156 [Multi-domain]  Cd Length: 761  Bit Score: 54.93  E-value: 9.31e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607  36 FLSLALWGA---LMTSSICLRQTDLKSLIAYSSISHMGLVIAASMIQTHWSFSGAMILMISHGLTSSMLFCLANTNYERT 112
Cdd:PRK12647 259 QTILPLFGGltmLTGALLAVRQTDLKLILAYSTVSALGTLVMLLGLGSELAIKAAVLFLVAHSLYKGALFMVAGIIDHET 338

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 164613607 113 HSRILILARGLQPLLPLMSTWWLLANLTNMALPPTTNLMAELTIMIALFNWSPLTILMTGAATF 176
Cdd:PRK12647 339 GTRDITKLGGLRRAMPITAAAALLAALSMAGLPPLFGFLAKELIYEALLEAPLWSLILTVAAVL 402
PRK07234 PRK07234
putative monovalent cation/H+ antiporter subunit D; Reviewed
 14-187 9.34e-08

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 235978 [Multi-domain]  Cd Length: 470  Bit Score: 51.88  E-value: 9.34e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607  14 GGYGIMRITLLTGPIPDALYYpflsLALWGALMTSSICLRQTDLKSLIAYSSISHMGLVIAASMIqthwsfsgAMILMIS 93
Cdd:PRK07234 230 GVFPLVRCALDVPGLDLIVRI----FGVGTALLGVLFALLEKDLKRMLAFSTISQLGFILAAPLV--------GGLYALA 297

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607  94 HGLTSSMLFCLANTNYERTHSRILILARGLQPLLPLmstwwLLANLTNMALPPTTNLMAELTIMIALFNWspLTILMTGA 173
Cdd:PRK07234 298 HGLVKSTLFLCAGALPSRNFTELISQMLGIGKWIPL-----TMASFSIAGFPLLAGFVSKVLTLKNLLPW--QAIALNLA 370

                        170
                 ....*....|....
gi 164613607 174 ATFLTASYTLFMFT 187
Cdd:PRK07234 371 AVGTAASFWKFIFL 384
NuoL COG1009
Membrane H+-translocase/NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ ...
 44-198 1.86e-07

Membrane H+-translocase/NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit [Energy production and conversion]; Membrane H+-translocase/NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440633 [Multi-domain]  Cd Length: 608  Bit Score: 50.92  E-value: 1.86e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607  44 ALMTSSICLRQTDLKSLIAYSSISHMGLVIAASMIQthwSFSGAMILMISHGLTSSMLFCLANTNYERTHSRILILARGL 123
Cdd:COG1009  286 ALFAALIALAQTDIKRVLAYSTVSQLGYMFLALGVG---AYVAALFHLLTHAFFKALLFLGAGSVIHATGTRDIRKMGGL 362

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607 124 QPLLPLMSTWWLLANLTNMALPPTTNLMAELTIMIALFNWSPLTILMTGAAT---FLTASYTLFM----FTTTQRGPLPT 196
Cdd:COG1009  363 RKKMPITAITFLIGALSLAGIPPFAGFFSKEAILEAALEAGGLGPLLLAVALlgaFLTAFYSFRLfflvFFGKPRPKTPK 442


                 ..
gi 164613607 197 HI 198
Cdd:COG1009  443 HP 444
PRK12650 PRK12650
DUF4040 family protein;
44-147 8.06e-07

DUF4040 family protein;


Pssm-ID: 237158 [Multi-domain]  Cd Length: 962  Bit Score: 49.27  E-value: 8.06e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607  44 ALMTSSICLRQTDLKSLIAYSSISHMGLVIAASMIQTHWSFSGAMILMISHGLTSSMLFCLANTNYERTHSRILilaRGL 123
Cdd:PRK12650 283 ALMGAVFAVQKTDLKKLTAYSTVSQLGWIVATIGVGTPFALTAAVVHTLAHALFKSSLFMLIGVVDHQAGTRDI---RRL 359

                         90       100
                 ....*....|....*....|....*..
gi 164613607 124 QPL---LPLMSTWWLLANLTNMALPPT 147
Cdd:PRK12650 360 GSLwrrMPFTFVSVTIAALSMAAVPPL 386
PRK06589 PRK06589
putative monovalent cation/H+ antiporter subunit D; Reviewed
 47-162 9.16e-07

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 235835 [Multi-domain]  Cd Length: 489  Bit Score: 49.04  E-value: 9.16e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607  47 TSSICLRQTDLKSLIAYSSISHMGLVIAASMIQTHWSFSGAMILMISHGLTSSMLFCLANTNYERTHSRILILARGLQPL 126
Cdd:PRK06589 294 SSLKALKTDNIKKILAYSTISQLSLALLSAFILTPKALGAAILHLVSHSFAKICLFYSMGSIYSLKKEDQVDKLHGTSKS 373

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 164613607 127 LPLMSTWWLLANLTNMALPPTTNLMAELTIMIALFN 162
Cdd:PRK06589 374 FPLISFIISISSLSLIGIPIFSGFISKFLILLAASE 409
PRK08377 PRK08377
NADH dehydrogenase subunit N; Validated
 50-188 1.58e-06

NADH dehydrogenase subunit N; Validated


Pssm-ID: 181406 [Multi-domain]  Cd Length: 494  Bit Score: 48.22  E-value: 1.58e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607  50 ICLRQTDLKSLIAYSSISHMGLVIAASMIQTHWSFSGAMILMISHGLTSSMLFCLANTNYERTHSRILILARGLQPLLPL 129
Cdd:PRK08377 290 SALRQKNVKRMIAYSSIGQVGMIALALALGTQAGVDAGVFHMINHAIVKALLFLAVGYVGITLGGTEIEKFEGLGKRMPL 369

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 164613607 130 MSTWWLLANLTNMALPpttnlmaeltimiaLFN--WSPLTILMTGAATFLTASYTLFMFTT 188
Cdd:PRK08377 370 TALALTIGALSTVGIP--------------LFNvfWSKFRIILAGLSAGYTWPVALVLGAS 416
PRK12662 PRK12662
putative monovalent cation/H+ antiporter subunit D; Reviewed
 36-182 6.01e-06

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 183662 [Multi-domain]  Cd Length: 492  Bit Score: 46.27  E-value: 6.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607  36 FLSLALWGALMTSSICLRQTDLKSLIAYSSISHMGLVIAASMIQTHWSFSGAMILMISHGLTSSMLFCLANT---NYERT 112
Cdd:PRK12662 282 FMILAALAIVFGSVLAILSKDIKRIFAYSSISHIGYIILAVSLNTYYGLAAAVAYIVNHSIVKSALFMVSGSisyHFGTT 361

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 164613607 113 HSRILIlarGLQPLLPLMSTWWLLANLTNMALPPTTNLMAELTIMIALFN---WSPLTILMTGaaTFLTASYT 182
Cdd:PRK12662 362 KLEDCL---NLWKSMPKITLAFVLLSLSLIGMPPTSGFVAKWYILDAFIKsnaWIGLVVLLVG--SGLSVIYV 429
PRK05777 PRK05777
NADH-quinone oxidoreductase subunit NuoN;
52-98 1.10e-05

NADH-quinone oxidoreductase subunit NuoN;


Pssm-ID: 235603 [Multi-domain]  Cd Length: 476  Bit Score: 45.58  E-value: 1.10e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 164613607  52 LRQTDLKSLIAYSSISHMGLVIAASMIQTHWSFSGAMILMISHGLTS 98
Cdd:PRK05777 289 LSQTNIKRLLAYSSIAHAGYLLVGLAAGTAEGYSAVLFYLLAYLFMT 335
PRK08667 PRK08667
hydrogenase membrane subunit; Validated
 16-161 1.22e-05

hydrogenase membrane subunit; Validated


Pssm-ID: 236331 [Multi-domain]  Cd Length: 644  Bit Score: 45.49  E-value: 1.22e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607  16 YGIMRItlLTGPIPDALYYPFLSLAL--WGALMTSSICLRQTDLKSLIAYSSISHMGLV---IAASMIQTHW-------- 82
Cdd:PRK08667 253 YGLVRF--LMDVLSPELWWGVLILLAgsISALLGVIYALKEHDLKGLLAYSSIENIGIIlmgIGLYVIFGVYgldtlall 330

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 164613607  83 SFSGAMILMISHGLTSSMLFCLANTNYERTHSRILILARGLQPLLPLMSTWWLLANLTNMALPPTTNLMAELTIMIALF 161
Cdd:PRK08667 331 ALGGALFHSLNHALFKSLLFLTAGSVVHATGTRNIEKMGGLVKLMPYTSALFLVGAVSIAALPPFNGFASELLLYESFF 409
PRK06525 PRK06525
hydrogenase 4 subunit D; Validated
 14-170 1.33e-05

hydrogenase 4 subunit D; Validated


Pssm-ID: 180606 [Multi-domain]  Cd Length: 479  Bit Score: 45.35  E-value: 1.33e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607  14 GGYGIMRITLLTGPIPDALYYPFLSLALWGALMTSSICLRQTDLKSLIAYSSISHMG---LVIAASMIQTHWSFSGAMIL 90
Cdd:PRK06525 253 GVYIFARAIQSMGPIPHVIGYVGAVMAIVTLLYGFLMYLPQQDMKRLLAYSTITQLGymfFGLSLAILGSRLALEGSIAY 332

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607  91 MISHGLTSSMLFCLANTNYERTHSRILILARGLQPLLPLMSTWWLLANLTNMALPPTTNLMAELTIMIALF-------NW 163
Cdd:PRK06525 333 IFNHAFAKSLFFLVAGALSYSCGTRLLPRLRGVLKKLPLVGVGFCVAALAITGVPPFNGFFSKFPIFAAGFelsveywIL 412


                 ....*..
gi 164613607 164 SPLTILM 170
Cdd:PRK06525 413 LPAMVLL 419
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 52-98 2.46e-05

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 44.72  E-value: 2.46e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 164613607  52 LRQTDLKSLIAYSSISHMGLVIAASMIQTHWSFSGAMILMISHGLTS 98
Cdd:COG1007  288 LAQTNVKRMLAYSSIAHAGYLLLGLAAGTPLGVSAALFYLLAYLFMN 334
PRK06277 PRK06277
energy conserving hydrogenase EhbF;
37-185 1.46e-04

energy conserving hydrogenase EhbF;


Pssm-ID: 235767 [Multi-domain]  Cd Length: 478  Bit Score: 42.33  E-value: 1.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607  37 LSLALWGALMTSSICLRQTDLKSLIAYSSISHMGLVIAASMIQTHWSFSGAMILMISHGLTSSMLFCLANTNYERTHSRI 116
Cdd:PRK06277 270 IALSVLAMVFGVVMALLQTDYKRLLAYHAISQGGYVAAGLALGTPLGIVAGIFHAINHVIYKSALFLGAGIVSYRTKTSN 349

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 164613607 117 LILARGLQPLLPLMSTWWLLANLTNMALPPTTNLMAELTIMIALF--NWSPLTILMTGAA-----TFLTASYTLFM 185
Cdd:PRK06277 350 LRKLGGLLPVMPVVAFMVLCAKLAISGVPPFNGFQSKLMLAQAAMqaNMPELAIIMIIVSigtfvSMMKAFYLIYL 425
PRK08668 PRK08668
NADH dehydrogenase subunit M; Validated
 53-102 2.35e-04

NADH dehydrogenase subunit M; Validated


Pssm-ID: 236332 [Multi-domain]  Cd Length: 610  Bit Score: 41.52  E-value: 2.35e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 164613607  53 RQTDLKSLIAYSSISHMGLVIAASMIQTHWSFSGAMILMISHGLTSSMLF 102
Cdd:PRK08668 292 LQEDIKKLIAYSSVANGGYILVGLGLGTSLGFAGGLFHVFNHALFKGLFF 341
PRK08676 PRK08676
hydrogenase membrane subunit; Validated
 52-180 2.84e-04

hydrogenase membrane subunit; Validated


Pssm-ID: 181537 [Multi-domain]  Cd Length: 485  Bit Score: 41.28  E-value: 2.84e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607  52 LRQTDLKSLIAYSSISHMGLVIAASMIQTHWSFSGAMILMISHGLTSSMLFCLANTNYERTHSRILILARGLQPLLPLMS 131
Cdd:PRK08676 292 LSQRNLKKLIAFSSIEHMGLMLLGIGIGTPLALFWMLFHMLAHSLVKSGLFFSAGILHRQYRSDRFDRIFDVFRLQPVAA 371

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 164613607 132 TWWLLANLTNMALPPTTNLMAELTIMIALFNWSPLTILMTGAATFLTAS 180
Cdd:PRK08676 372 WGVILGSAAIIGMPPFPLFLSKFFILLQLGGISVWLVLAVLLLLLLAAS 420
PRK12646 PRK12646
DUF4040 family protein;
14-194 1.59e-03

DUF4040 family protein;


Pssm-ID: 183646 [Multi-domain]  Cd Length: 800  Bit Score: 39.35  E-value: 1.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607  14 GGYGIMRITLLTGpIPDALYYPFLSLALWGALMTSSICLRQTDLKSLIAYSSISHMGLVIaaSMI--------QTHWSFS 85
Cdd:PRK12646 256 GIFLLFRFTPLLG-LSNMYIYIVTFVGLITMLFGSITALKQWDLKGILAYSTISQLGMIM--AMVgigggyaqHQQDAIA 332

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607  86 --------GAMILMISHGLTSSMLFCLANTNYERTHSRILILARGLQPLLPLMSTWWLLANLTNMALPPTTNLMAELTIM 157
Cdd:PRK12646 333 siyvfvlfAALFHLMNHAIFKCALFMGVGIIDHEAGTRDIRILSGMRQLFPKMNLVMTIAALSMAGVPFLNGFLSKEMFL 412

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 164613607 158 IALFNWSPL-------TILMTG---AATFLTASYTLFMFTTTQRGPL 194
Cdd:PRK12646 413 DALTQTGQLsqfslisMIIIVFigvIASIFTFTYALYMVKEVFWGKY 459
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 16-176 2.50e-03

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 38.39  E-value: 2.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607   16 YGIMRITLLtgpIPDALYYPFLSLALWGALMT----SSICLRQTDLKSLIAYSSISHMGLVIAASMIQTHWSFSGAMILM 91
Cdd:TIGR01770 251 AVFLRLFLY---ILFGFSEAWQIFLAIIAFLSmligNFGALAQKKVKRLLAYSSISHVGYILIGLLAGTLEGIKAVLFYI 327

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607   92 ISHGLTS----SMLFCLANTNYERTHSriLILARGLQPLLPLMSTWWLLANLTNMALPPTTNLMAELTIMIALFN----- 162
Cdd:TIGR01770 328 FIYALMSlgafGVLSLLRSYKDEWIEY--ISDFAGLFKTNPILAILILIFMFSLAGIPPLAGFFGKFYVFFALLKsglyw 405

                         170
                  ....*....|....
gi 164613607  163 WSPLTILMTGAATF 176
Cdd:TIGR01770 406 LAVIAVLTSVIGAF 419
ND2 MTH00011
NADH dehydrogenase subunit 2; Validated
 37-171 3.97e-03

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 164587 [Multi-domain]  Cd Length: 330  Bit Score: 37.84  E-value: 3.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607  37 LSLALWGALMTSSICLRQTDLKSLIAYSSISHMGLViaaSMIQTHWSFSGAMILMISHGLTSSMLFCLANTNYERTHSRI 116
Cdd:MTH00011 151 TSMAAMSALAGGLGGMNQTQLRPLLAYSSIGHMGWM---TMISVFSPSMAILYFMTYIIITTPLMLLFAYLNAFSTKFNS 227

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 164613607 117 LILARGlqpllPLMSTWWLLANLTNMALPPTTNLMAELTIMIALFNWSPLTILMT 171
Cdd:MTH00011 228 KISSMS-----QTTSMSLFIMLLSLGGLPPFTGFMPKLMAIETLTSNSMILILLV 277
PRK06521 PRK06521
hydrogenase 4 subunit B; Validated
 16-161 8.39e-03

hydrogenase 4 subunit B; Validated


Pssm-ID: 235820 [Multi-domain]  Cd Length: 667  Bit Score: 36.79  E-value: 8.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607  16 YGIMRITLLTGPIPDALY-YPFLSLALWGALMTSSICLRQTDLKSLIAYSSISHMGLVIAA---SMI--------QTHWS 83
Cdd:PRK06521 258 YGILRVVFDLLGAPGWWWgVLVLALGAISAVLGVLYALAEHDLKRLLAYSTIENIGIIFVGlglAMVfiaygmplLAALA 337

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 164613607  84 FSGAMILMISHGLTSSMLFCLANTNYERTHSRILILARGLQPLLPLMSTWWLLANLTNMALPPTTNLMAELTIMIALF 161
Cdd:PRK06521 338 LTAALYHLLNHALFKSLLFLGAGAVLHATGTRDMEKLGGLIRRMPWTAWAFLIGCLAISALPPLNGFVSEWLLLQSLL 415
ND2 MTH00144
NADH dehydrogenase subunit 2; Provisional
 31-186 9.94e-03

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214432 [Multi-domain]  Cd Length: 328  Bit Score: 36.40  E-value: 9.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164613607  31 ALYYPFLSLALWGALMTSSICLRQTDLKSLIAYSSISHMGLVIAASMIQTHWSFSGAMI-LMISHGLTSSMLFCLANTNY 109
Cdd:MTH00144 142 WLAYLLCVISVLSALVGSIGGLNQTQVRALLAYSSISHTGWMLVAILHGSWLMWMYFLIyIVSSGFLFFSLWSGDSGSMK 221

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 164613607 110 ERTHSRililarglqpLLPLMSTWWLLANLTNMALPPTTNLMAELTIMIALFNWSP-LTILMTGAATFLTASYTLFMF 186
Cdd:MTH00144 222 DLGSLK----------PSYKTGLSIISLLLSLGGLPPFLGFCSKLLVLISSMESSPlLLILLLLLGSLISLFFYLSVF 289
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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