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Conserved domains on  [gi|188484415|gb|ACD50835|]
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cystatin, partial [Bracoviriform kariyai]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CY super family cl09238
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 20-85 1.39e-11

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


The actual alignment was detected with superfamily member smart00043:

Pssm-ID: 447698  Cd Length: 107  Bit Score: 55.51  E-value: 1.39e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 188484415    20 VGGKQQVPVDDEGVKEAAEIIMRKINEEYRGERALMLVAVEEAQCQIVSGMKYYLNLTVSESHCLK 85
Cdd:smart00043   3 LGGPSDVPPNDPEVQEAADFAVAEYNKKSNDKYELRVIKVVSAKSQVVAGTNYYLKVEVGETNCKK 68
 
Name Accession Description Interval E-value
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 20-85 1.39e-11

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 55.51  E-value: 1.39e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 188484415    20 VGGKQQVPVDDEGVKEAAEIIMRKINEEYRGERALMLVAVEEAQCQIVSGMKYYLNLTVSESHCLK 85
Cdd:smart00043   3 LGGPSDVPPNDPEVQEAADFAVAEYNKKSNDKYELRVIKVVSAKSQVVAGTNYYLKVEVGETNCKK 68
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 21-85 4.62e-10

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 51.71  E-value: 4.62e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 188484415  21 GGKQQVPVDDEGVKEAAEIIMRKINEEYRGeRALMLVAVEEAQCQIVSGMKYYLNLTVSESHCLK 85
Cdd:cd00042    1 GGPSDIPANDPEVQELADFAVAEYNKKSND-KYLEFFKVLSAKSQVVAGTNYYITVEAGDTNCKK 64
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 21-86 1.05e-09

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 50.41  E-value: 1.05e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 188484415  21 GGKQQVPVDDEGVKEAAEIIMRKINEEYRGERaLMLVAVEEAQCQIVSGMKYYLNLTVSESHCLKN 86
Cdd:pfam00031  1 GGLSPIPDNSPELQEALDFALAEYNAKTDNYY-FELVEVKRAKSQVVAGTNYFIKVEVGETDCSKS 65
 
Name Accession Description Interval E-value
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 20-85 1.39e-11

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 55.51  E-value: 1.39e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 188484415    20 VGGKQQVPVDDEGVKEAAEIIMRKINEEYRGERALMLVAVEEAQCQIVSGMKYYLNLTVSESHCLK 85
Cdd:smart00043   3 LGGPSDVPPNDPEVQEAADFAVAEYNKKSNDKYELRVIKVVSAKSQVVAGTNYYLKVEVGETNCKK 68
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 21-85 4.62e-10

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 51.71  E-value: 4.62e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 188484415  21 GGKQQVPVDDEGVKEAAEIIMRKINEEYRGeRALMLVAVEEAQCQIVSGMKYYLNLTVSESHCLK 85
Cdd:cd00042    1 GGPSDIPANDPEVQELADFAVAEYNKKSND-KYLEFFKVLSAKSQVVAGTNYYITVEAGDTNCKK 64
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 21-86 1.05e-09

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 50.41  E-value: 1.05e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 188484415  21 GGKQQVPVDDEGVKEAAEIIMRKINEEYRGERaLMLVAVEEAQCQIVSGMKYYLNLTVSESHCLKN 86
Cdd:pfam00031  1 GGLSPIPDNSPELQEALDFALAEYNAKTDNYY-FELVEVKRAKSQVVAGTNYFIKVEVGETDCSKS 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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