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Conserved domains on  [gi|209447632|gb|ACI47104|]
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NADH dehydrogenase subunit 4L (mitochondrion) [Mirza zaza]

Protein Classification

NADH-ubiquinone oxidoreductase chain 4L( domain architecture ID 10009568)

NADH-ubiquinone oxidoreductase chain 4L is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) and is believed to belong to the minimal assembly required for catalysis; Complex I functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 6.21e-37

NADH dehydrogenase subunit 4L; Provisional


:

Pssm-ID: 177169  Cd Length: 98  Bit Score: 120.04  E-value: 6.21e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209447632  1 MPSISINITLAFTTALLGMLMFRSHMMSSLLCLEGMMLSMFILSTLIILNVQLTMSFMMPILLLVFAACEAAIGLALLVM 80
Cdd:MTH00107  1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                        90
                ....*....|....*...
gi 209447632 81 ISNTYGLDYIQNLNLLQC 98
Cdd:MTH00107 81 VSNTYGTDYVQNLNLLQC 98
 
Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 6.21e-37

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 120.04  E-value: 6.21e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209447632  1 MPSISINITLAFTTALLGMLMFRSHMMSSLLCLEGMMLSMFILSTLIILNVQLTMSFMMPILLLVFAACEAAIGLALLVM 80
Cdd:MTH00107  1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                        90
                ....*....|....*...
gi 209447632 81 ISNTYGLDYIQNLNLLQC 98
Cdd:MTH00107 81 VSNTYGTDYVQNLNLLQC 98
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
3-98 1.67e-10

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 52.57  E-value: 1.67e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209447632   3 SISINITLAFTTALLGMLmFRSHMMSSLLCLEGMMLSMFILSTLIILNVQLTMSFMMPILLLVFAACEAAIGLALLVMIS 82
Cdd:pfam00420  1 AYLLLSGLLFLIGLYGLL-LRRNLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIY 79

                         90
                 ....*....|....*.
gi 209447632  83 NTYGLDYIQNLNLLQC 98
Cdd:pfam00420 80 RTHGTDDVDSLNLLKG 95
 
Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 6.21e-37

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 120.04  E-value: 6.21e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209447632  1 MPSISINITLAFTTALLGMLMFRSHMMSSLLCLEGMMLSMFILSTLIILNVQLTMSFMMPILLLVFAACEAAIGLALLVM 80
Cdd:MTH00107  1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                        90
                ....*....|....*...
gi 209447632 81 ISNTYGLDYIQNLNLLQC 98
Cdd:MTH00107 81 VSNTYGTDYVQNLNLLQC 98
ND4L MTH00126
NADH dehydrogenase subunit 4L; Provisional
 1-98 4.44e-22

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177185  Cd Length: 98  Bit Score: 82.32  E-value: 4.44e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209447632  1 MPSISINITLAFTTALLGMLMFRSHMMSSLLCLEGMMLSMFILSTLIILNVQLTMSFMMPILLLVFAACEAAIGLALLVM 80
Cdd:MTH00126  1 MTPVHFSFSSAFILGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWALQLESTSFSAAPMLLLAFSACEASAGLALLVA 80

                        90
                ....*....|....*...
gi 209447632 81 ISNTYGLDYIQNLNLLQC 98
Cdd:MTH00126 81 TARTHGTDRLQNLNLLQC 98
ND4L MTH00125
NADH dehydrogenase subunit 4L; Provisional
 1-98 4.19e-20

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177184  Cd Length: 98  Bit Score: 77.19  E-value: 4.19e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209447632  1 MPSISINITLAFTTALLGMLMFRSHMMSSLLCLEGMMLSMFILSTLIILNVQLTMSFMMPILLLVFAACEAAIGLALLVM 80
Cdd:MTH00125  1 MTPTHFSLYTAFMLSLLGLSFHRTHLMSALLCLESMMLSLFIMLSLWPITTQTPSFTPMPIILLTFSACEAGTGLALLVA 80

                        90
                ....*....|....*...
gi 209447632 81 ISNTYGLDYIQNLNLLQC 98
Cdd:MTH00125 81 TTRTHGSDHLKNLNLLQC 98
ND4L MTH00067
NADH dehydrogenase subunit 4L; Provisional
 1-98 5.50e-17

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177139  Cd Length: 98  Bit Score: 69.25  E-value: 5.50e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209447632  1 MPSISINITLAFTTALLGMLMFRSHMMSSLLCLEGMMLSMFILSTLIILNVQLTMSFMMPILLLVFAACEAAIGLALLVM 80
Cdd:MTH00067  1 MSPTYFTFYSAFLLGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWSTQFESLSYFSLPMFMLTFSACEASTGLALMVA 80

                        90
                ....*....|....*...
gi 209447632 81 ISNTYGLDYIQNLNLLQC 98
Cdd:MTH00067 81 TTRTHGTDHLKNLNLLQC 98
ND4L MTH00181
NADH dehydrogenase subunit 4L; Provisional
 9-96 1.55e-11

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214450  Cd Length: 93  Bit Score: 55.34  E-value: 1.55e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209447632  9 TLAFTTALLGMLMFRSHMMSSLLCLEGMMLSMFILSTLIILNVQLTMSFMMPILLLVFAACEAAIGLALLVMISNTYGLD 88
Cdd:MTH00181  6 ISAFILLLLGLSLYKTHLLSLLLCLEGMMLFLFLLLALFSLLSSSSSMLMFGLILLTFSACEAVLGLSLLVATNRTHGSD 85


                ....*...
gi 209447632 89 YIQNLNLL 96
Cdd:MTH00181 86 HLLKFNLL 93
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
3-98 1.67e-10

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 52.57  E-value: 1.67e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209447632   3 SISINITLAFTTALLGMLmFRSHMMSSLLCLEGMMLSMFILSTLIILNVQLTMSFMMPILLLVFAACEAAIGLALLVMIS 82
Cdd:pfam00420  1 AYLLLSGLLFLIGLYGLL-LRRNLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIY 79

                         90
                 ....*....|....*.
gi 209447632  83 NTYGLDYIQNLNLLQC 98
Cdd:pfam00420 80 RTHGTDDVDSLNLLKG 95
ND4L MTH00043
NADH dehydrogenase subunit 4L; Validated
 1-97 7.13e-09

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 214410  Cd Length: 98  Bit Score: 48.38  E-value: 7.13e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209447632  1 MPSISINITLAFTTALLGMLMFRSHMMSSLLCLEGMMLSMFILSTLIILNVQLTMSFMMPILLLVFAACEAAIGLALLVM 80
Cdd:MTH00043  1 MNIILIIILSSFFLGLLGILINRLHLLSILLCLELLLISLFLNISIWSLNYGNFSNLSFSLLLLTLSACEASIGLSLMVL 80

                        90
                ....*....|....*..
gi 209447632 81 ISNTYGLDYIQNLNLLQ 97
Cdd:MTH00043 81 LSRNHNSDLVASLNLLQ 97
ND4L MTH00188
NADH dehydrogenase subunit 4L; Provisional
 8-98 5.13e-07

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177237  Cd Length: 97  Bit Score: 43.81  E-value: 5.13e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209447632  8 ITLAFTTALLGMLMFRSHMMSSLLCLEGMMLSMFILSTLIILNVQLtmSFMMPILLLVFAACEAAIGLALLVMISNTYGL 87
Cdd:MTH00188  9 ILLFVVLGLFTFLLNRKHLLMLLLSLEAIMLSLFWFLLVGLSYMEK--ELYLSLVLLTFAACEASVGLALLVSLIRSHGS 86

                        90
                ....*....|.
gi 209447632 88 DYIQNLNLLQC 98
Cdd:MTH00188 87 DYVSSLNLIKC 97
ND4L MTH00162
NADH dehydrogenase subunit 4L; Provisional
 12-92 2.12e-06

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177218  Cd Length: 89  Bit Score: 42.06  E-value: 2.12e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209447632 12 FTTALLGMLMFRSHMMSSLLCLEGMMLSMFILstLIILNVQLTMSFMMPILLLVFAACEAAIGLALLVMISNTYGLDYIQ 91
Cdd:MTH00162 11 FFSGLLVFLSKRKHLLLMLLSLEFMVLSLFFL--LFLYLSFFNYELYFLLFFLTFSVCEGALGLSILVSMIRSHGNDYFS 88


                .
gi 209447632 92 N 92
Cdd:MTH00162 89 S 89
ND4L MTH00149
NADH dehydrogenase subunit 4L; Provisional
 9-98 3.17e-06

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214434  Cd Length: 97  Bit Score: 41.75  E-value: 3.17e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209447632  9 TLAFTTALLGMLMFRSHMMSSLLCLEGMMLSMFILstLIILNVQLTMSFMMPILLLVFAACEAAIGLALLVMISNTYGLD 88
Cdd:MTH00149 10 LFGFLMGVFALLFQYKHLLSILLSLEALMLSLLVM--MFSSSGLISFSSYLFLIILTFGACEASLGLSLLVSLIRLHGND 87

                        90
                ....*....|
gi 209447632 89 YIQNLNLLQC 98
Cdd:MTH00149 88 YVSSLSSLKF 97
ND4L MTH00013
NADH dehydrogenase subunit 4L; Validated
 1-98 2.42e-05

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 133655  Cd Length: 97  Bit Score: 39.35  E-value: 2.42e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209447632  1 MPSISINITLAFTTALLGMLMFRSHMMSSLLCLEGMMLSMFILsTLIILNVQLTMSFMMPILLLVFAACEAAIGLALLVM 80
Cdd:MTH00013  1 MMSPLFILSISPFISMFNLSLQRKHLLMSLLSLEAMILSLALF-IPLSLMFANQVNGMLAIVLLTFGACEASLGLSLLVL 79

                        90
                ....*....|....*...
gi 209447632 81 ISNTYGLDYIQNLNLLQC 98
Cdd:MTH00013 80 MTRSYGNDMLKSLTSNKC 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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