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Conserved domains on  [gi|306486240|gb|ADM92764|]
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NADH dehydrogenase subunit 4L (mitochondrion) [Microcebus simmonsi]

Protein Classification

NADH-ubiquinone oxidoreductase chain 4L( domain architecture ID 10009568)

NADH-ubiquinone oxidoreductase chain 4L is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) and is believed to belong to the minimal assembly required for catalysis; Complex I functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.15e-37

NADH dehydrogenase subunit 4L; Provisional


:

Pssm-ID: 177169  Cd Length: 98  Bit Score: 121.58  E-value: 1.15e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306486240  1 MPSISININLAFATALLGMLMFRSHMMSSLLCLEGMMLSMFILSTLTILNMQFTMSFTMPILLLVFAACEAAIGLALLVM 80
Cdd:MTH00107  1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                        90
                ....*....|....*...
gi 306486240 81 VSNNYGLDYIQNLNLLQC 98
Cdd:MTH00107 81 VSNTYGTDYVQNLNLLQC 98
 
Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.15e-37

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 121.58  E-value: 1.15e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306486240  1 MPSISININLAFATALLGMLMFRSHMMSSLLCLEGMMLSMFILSTLTILNMQFTMSFTMPILLLVFAACEAAIGLALLVM 80
Cdd:MTH00107  1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                        90
                ....*....|....*...
gi 306486240 81 VSNNYGLDYIQNLNLLQC 98
Cdd:MTH00107 81 VSNTYGTDYVQNLNLLQC 98
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
3-98 8.74e-11

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 53.34  E-value: 8.74e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306486240   3 SISININLAFATALLGMLmFRSHMMSSLLCLEGMMLSMFILSTLTILNMQFTMSFTMPILLLVFAACEAAIGLALLVMVS 82
Cdd:pfam00420  1 AYLLLSGLLFLIGLYGLL-LRRNLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIY 79

                         90
                 ....*....|....*.
gi 306486240  83 NNYGLDYIQNLNLLQC 98
Cdd:pfam00420 80 RTHGTDDVDSLNLLKG 95
 
Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.15e-37

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 121.58  E-value: 1.15e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306486240  1 MPSISININLAFATALLGMLMFRSHMMSSLLCLEGMMLSMFILSTLTILNMQFTMSFTMPILLLVFAACEAAIGLALLVM 80
Cdd:MTH00107  1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                        90
                ....*....|....*...
gi 306486240 81 VSNNYGLDYIQNLNLLQC 98
Cdd:MTH00107 81 VSNTYGTDYVQNLNLLQC 98
ND4L MTH00126
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.03e-21

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177185  Cd Length: 98  Bit Score: 81.16  E-value: 1.03e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306486240  1 MPSISININLAFATALLGMLMFRSHMMSSLLCLEGMMLSMFILSTLTILNMQFTMSFTMPILLLVFAACEAAIGLALLVM 80
Cdd:MTH00126  1 MTPVHFSFSSAFILGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWALQLESTSFSAAPMLLLAFSACEASAGLALLVA 80

                        90
                ....*....|....*...
gi 306486240 81 VSNNYGLDYIQNLNLLQC 98
Cdd:MTH00126 81 TARTHGTDRLQNLNLLQC 98
ND4L MTH00125
NADH dehydrogenase subunit 4L; Provisional
 1-98 5.44e-20

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177184  Cd Length: 98  Bit Score: 76.81  E-value: 5.44e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306486240  1 MPSISININLAFATALLGMLMFRSHMMSSLLCLEGMMLSMFILSTLTILNMQFTMSFTMPILLLVFAACEAAIGLALLVM 80
Cdd:MTH00125  1 MTPTHFSLYTAFMLSLLGLSFHRTHLMSALLCLESMMLSLFIMLSLWPITTQTPSFTPMPIILLTFSACEAGTGLALLVA 80

                        90
                ....*....|....*...
gi 306486240 81 VSNNYGLDYIQNLNLLQC 98
Cdd:MTH00125 81 TTRTHGSDHLKNLNLLQC 98
ND4L MTH00067
NADH dehydrogenase subunit 4L; Provisional
 11-98 2.97e-16

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177139  Cd Length: 98  Bit Score: 67.32  E-value: 2.97e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306486240 11 AFATALLGMLMFRSHMMSSLLCLEGMMLSMFILSTLTILNMQFTMSFTMPILLLVFAACEAAIGLALLVMVSNNYGLDYI 90
Cdd:MTH00067 11 AFLLGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWSTQFESLSYFSLPMFMLTFSACEASTGLALMVATTRTHGTDHL 90


                ....*...
gi 306486240 91 QNLNLLQC 98
Cdd:MTH00067 91 KNLNLLQC 98
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
3-98 8.74e-11

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 53.34  E-value: 8.74e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306486240   3 SISININLAFATALLGMLmFRSHMMSSLLCLEGMMLSMFILSTLTILNMQFTMSFTMPILLLVFAACEAAIGLALLVMVS 82
Cdd:pfam00420  1 AYLLLSGLLFLIGLYGLL-LRRNLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIY 79

                         90
                 ....*....|....*.
gi 306486240  83 NNYGLDYIQNLNLLQC 98
Cdd:pfam00420 80 RTHGTDDVDSLNLLKG 95
ND4L MTH00181
NADH dehydrogenase subunit 4L; Provisional
 10-96 3.03e-10

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214450  Cd Length: 93  Bit Score: 51.87  E-value: 3.03e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306486240 10 LAFATALLGMLMFRSHMMSSLLCLEGMMLSMFILSTLTILNMQFTMSFTMPILLLVFAACEAAIGLALLVMVSNNYGLDY 89
Cdd:MTH00181  7 SAFILLLLGLSLYKTHLLSLLLCLEGMMLFLFLLLALFSLLSSSSSMLMFGLILLTFSACEAVLGLSLLVATNRTHGSDH 86


                ....*..
gi 306486240 90 IQNLNLL 96
Cdd:MTH00181 87 LLKFNLL 93
ND4L MTH00043
NADH dehydrogenase subunit 4L; Validated
 1-97 4.57e-10

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 214410  Cd Length: 98  Bit Score: 51.46  E-value: 4.57e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306486240  1 MPSISININLAFATALLGMLMFRSHMMSSLLCLEGMMLSMFILSTLTILNMQFTMSFTMPILLLVFAACEAAIGLALLVM 80
Cdd:MTH00043  1 MNIILIIILSSFFLGLLGILINRLHLLSILLCLELLLISLFLNISIWSLNYGNFSNLSFSLLLLTLSACEASIGLSLMVL 80

                        90
                ....*....|....*..
gi 306486240 81 VSNNYGLDYIQNLNLLQ 97
Cdd:MTH00043 81 LSRNHNSDLVASLNLLQ 97
ND4L MTH00188
NADH dehydrogenase subunit 4L; Provisional
 12-98 3.27e-07

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177237  Cd Length: 97  Bit Score: 44.19  E-value: 3.27e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306486240 12 FATALLGMLMFRSHMMSSLLCLEGMMLSMFILSTLTILNMQFtmSFTMPILLLVFAACEAAIGLALLVMVSNNYGLDYIQ 91
Cdd:MTH00188 13 VVLGLFTFLLNRKHLLMLLLSLEAIMLSLFWFLLVGLSYMEK--ELYLSLVLLTFAACEASVGLALLVSLIRSHGSDYVS 90


                ....*..
gi 306486240 92 NLNLLQC 98
Cdd:MTH00188 91 SLNLIKC 97
ND4L MTH00149
NADH dehydrogenase subunit 4L; Provisional
 10-98 2.16e-06

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214434  Cd Length: 97  Bit Score: 42.14  E-value: 2.16e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306486240 10 LAFATALLGMLMFRSHMMSSLLCLEGMMLSMFILSTLTILNMQFTMSFTMpiLLLVFAACEAAIGLALLVMVSNNYGLDY 89
Cdd:MTH00149 11 FGFLMGVFALLFQYKHLLSILLSLEALMLSLLVMMFSSSGLISFSSYLFL--IILTFGACEASLGLSLLVSLIRLHGNDY 88


                ....*....
gi 306486240 90 IQNLNLLQC 98
Cdd:MTH00149 89 VSSLSSLKF 97
ND4L MTH00162
NADH dehydrogenase subunit 4L; Provisional
 16-92 1.51e-05

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177218  Cd Length: 89  Bit Score: 39.75  E-value: 1.51e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 306486240 16 LLGMLMFRSHMMSSLLCLEGMMLSMFILSTLTILNMQFTMSFtmPILLLVFAACEAAIGLALLVMVSNNYGLDYIQN 92
Cdd:MTH00162 15 LLVFLSKRKHLLLMLLSLEFMVLSLFFLLFLYLSFFNYELYF--LLFFLTFSVCEGALGLSILVSMIRSHGNDYFSS 89
ND4L MTH00013
NADH dehydrogenase subunit 4L; Validated
 10-98 6.71e-05

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 133655  Cd Length: 97  Bit Score: 38.19  E-value: 6.71e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306486240 10 LAFATALLGMLMFRSHMMSSLLCLEGMMLSMFILSTLTILNMQFTMSFtMPILLLVFAACEAAIGLALLVMVSNNYGLDY 89
Cdd:MTH00013 10 ISPFISMFNLSLQRKHLLMSLLSLEAMILSLALFIPLSLMFANQVNGM-LAIVLLTFGACEASLGLSLLVLMTRSYGNDM 88


                ....*....
gi 306486240 90 IQNLNLLQC 98
Cdd:MTH00013 89 LKSLTSNKC 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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