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Conserved domains on  [gi|311088260|gb|ADP68318|]
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NADH dehydrogenase subunit 4L (mitochondrion) [Lepilemur wrightae]

Protein Classification

NADH-ubiquinone oxidoreductase chain 4L( domain architecture ID 10009568)

NADH-ubiquinone oxidoreductase chain 4L is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) and is believed to belong to the minimal assembly required for catalysis; Complex I functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 2.01e-36

NADH dehydrogenase subunit 4L; Provisional


:

Pssm-ID: 177169  Cd Length: 98  Bit Score: 118.49  E-value: 2.01e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088260  1 MPSISTNIILAFTTALMGMLVFRSHLMSSLLCLEGMMLSMFILSTLTIVNLHFTMSFTMPILLLVFSACEAAIGLALLVM 80
Cdd:MTH00107  1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                        90
                ....*....|....*...
gi 311088260 81 MSNTYGLDLIQNLNLLQC 98
Cdd:MTH00107 81 VSNTYGTDYVQNLNLLQC 98
 
Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 2.01e-36

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 118.49  E-value: 2.01e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088260  1 MPSISTNIILAFTTALMGMLVFRSHLMSSLLCLEGMMLSMFILSTLTIVNLHFTMSFTMPILLLVFSACEAAIGLALLVM 80
Cdd:MTH00107  1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                        90
                ....*....|....*...
gi 311088260 81 MSNTYGLDLIQNLNLLQC 98
Cdd:MTH00107 81 VSNTYGTDYVQNLNLLQC 98
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
3-98 1.03e-10

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 53.34  E-value: 1.03e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088260   3 SISTNIILAFTTALMGMLvFRSHLMSSLLCLEGMMLSMFILSTLTIVNLHFTMSFTMPILLLVFSACEAAIGLALLVMMS 82
Cdd:pfam00420  1 AYLLLSGLLFLIGLYGLL-LRRNLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIY 79

                         90
                 ....*....|....*.
gi 311088260  83 NTYGLDLIQNLNLLQC 98
Cdd:pfam00420 80 RTHGTDDVDSLNLLKG 95
 
Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 2.01e-36

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 118.49  E-value: 2.01e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088260  1 MPSISTNIILAFTTALMGMLVFRSHLMSSLLCLEGMMLSMFILSTLTIVNLHFTMSFTMPILLLVFSACEAAIGLALLVM 80
Cdd:MTH00107  1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                        90
                ....*....|....*...
gi 311088260 81 MSNTYGLDLIQNLNLLQC 98
Cdd:MTH00107 81 VSNTYGTDYVQNLNLLQC 98
ND4L MTH00126
NADH dehydrogenase subunit 4L; Provisional
 11-98 3.77e-23

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177185  Cd Length: 98  Bit Score: 85.02  E-value: 3.77e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088260 11 AFTTALMGMLVFRSHLMSSLLCLEGMMLSMFILSTLTIVNLHFTMSFTMPILLLVFSACEAAIGLALLVMMSNTYGLDLI 90
Cdd:MTH00126 11 AFILGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWALQLESTSFSAAPMLLLAFSACEASAGLALLVATARTHGTDRL 90


                ....*...
gi 311088260 91 QNLNLLQC 98
Cdd:MTH00126 91 QNLNLLQC 98
ND4L MTH00125
NADH dehydrogenase subunit 4L; Provisional
 1-98 6.75e-19

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177184  Cd Length: 98  Bit Score: 74.11  E-value: 6.75e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088260  1 MPSISTNIILAFTTALMGMLVFRSHLMSSLLCLEGMMLSMFILSTLTIVNLHFTMSFTMPILLLVFSACEAAIGLALLVM 80
Cdd:MTH00125  1 MTPTHFSLYTAFMLSLLGLSFHRTHLMSALLCLESMMLSLFIMLSLWPITTQTPSFTPMPIILLTFSACEAGTGLALLVA 80

                        90
                ....*....|....*...
gi 311088260 81 MSNTYGLDLIQNLNLLQC 98
Cdd:MTH00125 81 TTRTHGSDHLKNLNLLQC 98
ND4L MTH00067
NADH dehydrogenase subunit 4L; Provisional
 8-98 3.92e-17

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177139  Cd Length: 98  Bit Score: 69.63  E-value: 3.92e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088260  8 IILAFTTALMGMLVFRSHLMSSLLCLEGMMLSMFILSTLTIVNLHFTMSFTMPILLLVFSACEAAIGLALLVMMSNTYGL 87
Cdd:MTH00067  8 FYSAFLLGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWSTQFESLSYFSLPMFMLTFSACEASTGLALMVATTRTHGT 87

                        90
                ....*....|.
gi 311088260 88 DLIQNLNLLQC 98
Cdd:MTH00067 88 DHLKNLNLLQC 98
ND4L MTH00181
NADH dehydrogenase subunit 4L; Provisional
 9-96 1.96e-12

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214450  Cd Length: 93  Bit Score: 57.65  E-value: 1.96e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088260  9 ILAFTTALMGMLVFRSHLMSSLLCLEGMMLSMFILSTLTIVNLHFTMSFTMPILLLVFSACEAAIGLALLVMMSNTYGLD 88
Cdd:MTH00181  6 ISAFILLLLGLSLYKTHLLSLLLCLEGMMLFLFLLLALFSLLSSSSSMLMFGLILLTFSACEAVLGLSLLVATNRTHGSD 85


                ....*...
gi 311088260 89 LIQNLNLL 96
Cdd:MTH00181 86 HLLKFNLL 93
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
3-98 1.03e-10

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 53.34  E-value: 1.03e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088260   3 SISTNIILAFTTALMGMLvFRSHLMSSLLCLEGMMLSMFILSTLTIVNLHFTMSFTMPILLLVFSACEAAIGLALLVMMS 82
Cdd:pfam00420  1 AYLLLSGLLFLIGLYGLL-LRRNLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIY 79

                         90
                 ....*....|....*.
gi 311088260  83 NTYGLDLIQNLNLLQC 98
Cdd:pfam00420 80 RTHGTDDVDSLNLLKG 95
ND4L MTH00043
NADH dehydrogenase subunit 4L; Validated
 1-97 1.61e-10

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 214410  Cd Length: 98  Bit Score: 52.61  E-value: 1.61e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088260  1 MPSISTNIILAFTTALMGMLVFRSHLMSSLLCLEGMMLSMFILSTLTIVNLHFTMSFTMPILLLVFSACEAAIGLALLVM 80
Cdd:MTH00043  1 MNIILIIILSSFFLGLLGILINRLHLLSILLCLELLLISLFLNISIWSLNYGNFSNLSFSLLLLTLSACEASIGLSLMVL 80

                        90
                ....*....|....*..
gi 311088260 81 MSNTYGLDLIQNLNLLQ 97
Cdd:MTH00043 81 LSRNHNSDLVASLNLLQ 97
ND4L MTH00188
NADH dehydrogenase subunit 4L; Provisional
 8-98 3.31e-07

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177237  Cd Length: 97  Bit Score: 44.19  E-value: 3.31e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088260  8 IILAFTTALMGMLVFRSHLMSSLLCLEGMMLSMFILSTLTIVNLHFtmSFTMPILLLVFSACEAAIGLALLVMMSNTYGL 87
Cdd:MTH00188  9 ILLFVVLGLFTFLLNRKHLLMLLLSLEAIMLSLFWFLLVGLSYMEK--ELYLSLVLLTFAACEASVGLALLVSLIRSHGS 86

                        90
                ....*....|.
gi 311088260 88 DLIQNLNLLQC 98
Cdd:MTH00188 87 DYVSSLNLIKC 97
ND4L MTH00162
NADH dehydrogenase subunit 4L; Provisional
 8-92 2.82e-06

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177218  Cd Length: 89  Bit Score: 41.68  E-value: 2.82e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088260  8 IILAFTTALMGMLVFRSHLMSSLLCLEGMMLSMFILstLTIVNLHFTMSFTMPILLLVFSACEAAIGLALLVMMSNTYGL 87
Cdd:MTH00162  7 FLFMFFSGLLVFLSKRKHLLLMLLSLEFMVLSLFFL--LFLYLSFFNYELYFLLFFLTFSVCEGALGLSILVSMIRSHGN 84


                ....*
gi 311088260 88 DLIQN 92
Cdd:MTH00162 85 DYFSS 89
ND4L MTH00013
NADH dehydrogenase subunit 4L; Validated
 1-98 1.08e-05

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 133655  Cd Length: 97  Bit Score: 40.50  E-value: 1.08e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088260  1 MPSISTNIILAFTTALMGMLVFRSHLMSSLLCLEGMMLSMFILSTLTIVNLHFTMSFtMPILLLVFSACEAAIGLALLVM 80
Cdd:MTH00013  1 MMSPLFILSISPFISMFNLSLQRKHLLMSLLSLEAMILSLALFIPLSLMFANQVNGM-LAIVLLTFGACEASLGLSLLVL 79

                        90
                ....*....|....*...
gi 311088260 81 MSNTYGLDLIQNLNLLQC 98
Cdd:MTH00013 80 MTRSYGNDMLKSLTSNKC 97
ND4L MTH00149
NADH dehydrogenase subunit 4L; Provisional
 9-98 1.63e-05

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214434  Cd Length: 97  Bit Score: 39.83  E-value: 1.63e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088260  9 ILAFTTALMGMLVFRSHLMSSLLCLEGMMLSMFILSTLTIVNLHFTMSFTMpiLLLVFSACEAAIGLALLVMMSNTYGLD 88
Cdd:MTH00149 10 LFGFLMGVFALLFQYKHLLSILLSLEALMLSLLVMMFSSSGLISFSSYLFL--IILTFGACEASLGLSLLVSLIRLHGND 87

                        90
                ....*....|
gi 311088260 89 LIQNLNLLQC 98
Cdd:MTH00149 88 YVSSLSSLKF 97
ND4L MTH00180
NADH dehydrogenase subunit 4L; Provisional
 9-97 9.91e-03

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177231  Cd Length: 99  Bit Score: 32.70  E-value: 9.91e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088260  9 ILAFTTALMGMLVFRSHLMSSLLCLEGMMLSMFILSTLTIVNLHFTMSFTMPILLLVFSACEAAIGLALLVMMSNTYGLD 88
Cdd:MTH00180 10 IILFILGVLGIVLNRSNLIIMLMSIELMLLAISLLFLINSVAIDNLIGQIFTIMILTVAAAESAIGLAILVAYYRIRGTI 89


                ....*....
gi 311088260 89 LIQNLNLLQ 97
Cdd:MTH00180 90 AVKSLNLLR 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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