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Conserved domains on  [gi|311088305|gb|ADP68360|]
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NADH dehydrogenase subunit 6 (mitochondrion) [Lepilemur ruficaudatus]

Protein Classification

NADH dehydrogenase subunit 6( domain architecture ID 10009569)

NADH dehydrogenase subunit 6 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-172 3.65e-77

NADH dehydrogenase subunit 6; Provisional


:

Pssm-ID: 214421  Cd Length: 175  Bit Score: 227.76  E-value: 3.65e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088305   1 MIYVMFLLSVVFVLGFMSFSSKPSPIYGGVGLVVSGAVGCIIIMGFGGSFVGLMVFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088305  81 TWSSSVVVWGSLLVGLIMELLVVIWVMGQDSFEVVVGLDDLEDWVVFTGKEVNTVREDSLGVAALYDYVSWFMVVAGWSL 160
Cdd:MTH00109  82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                        170
                 ....*....|..
gi 311088305 161 FVSVLIVIEIIR 172
Cdd:MTH00109 162 FIGVFVIIEITR 173
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-172 3.65e-77

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 227.76  E-value: 3.65e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088305   1 MIYVMFLLSVVFVLGFMSFSSKPSPIYGGVGLVVSGAVGCIIIMGFGGSFVGLMVFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088305  81 TWSSSVVVWGSLLVGLIMELLVVIWVMGQDSFEVVVGLDDLEDWVVFTGKEVNTVREDSLGVAALYDYVSWFMVVAGWSL 160
Cdd:MTH00109  82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                        170
                 ....*....|..
gi 311088305 161 FVSVLIVIEIIR 172
Cdd:MTH00109 162 FIGVFVIIEITR 173
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
21-170 1.96e-09

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 53.28  E-value: 1.96e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088305   21 SKPSPIYGGVGLVVSGAVGCIIIMGFGGSFVGLMVFLVYLGGMLVVFGYTTAMATEEYPETWSSSVVVWGSLLVGLIMeL 100
Cdd:pfam00499   5 TSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGLLL-L 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088305  101 LVVIWVMGQDSFEVVVglddledwvvfTGKEVNTVREDSLGVAALYDYVsWFMVVAGWSLFVSVLIVIEI 170
Cdd:pfam00499  84 ALLLLVLLSASLTPAA-----------AAAAPDVGNIEAIGELLFTDYL-LPFELASVLLLVALVGAIVL 141
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-172 3.65e-77

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 227.76  E-value: 3.65e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088305   1 MIYVMFLLSVVFVLGFMSFSSKPSPIYGGVGLVVSGAVGCIIIMGFGGSFVGLMVFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088305  81 TWSSSVVVWGSLLVGLIMELLVVIWVMGQDSFEVVVGLDDLEDWVVFTGKEVNTVREDSLGVAALYDYVSWFMVVAGWSL 160
Cdd:MTH00109  82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                        170
                 ....*....|..
gi 311088305 161 FVSVLIVIEIIR 172
Cdd:MTH00109 162 FIGVFVIIEITR 173
ND6 MTH00138
NADH dehydrogenase subunit 6; Provisional
 1-172 2.96e-32

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 177196  Cd Length: 173  Bit Score: 113.31  E-value: 2.96e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088305   1 MIYVMFLLSVVFVLGFMSFSSKPSPIYGGVGLVVSGAVGCIIIMGFGGSFVGLMVFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00138   1 MTYLMSLFLLGLVLGLVAVASNPSPYFAALGLVVVAGVGCGVLVGHGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088305  81 TWSSSVVVwGSLLVGLIMELLVVIWVMGQDSFEVVVGLDDLEDWVVFtgkevntvREDSLGVAALYDYVSWFMVVAGWSL 160
Cdd:MTH00138  81 SWGSWSVL-GYVVGYLVGVVLAAGLFWGGWYEGSWVVVDELKEFSVL--------RGDVGGVALMYSSGGGMLVICAWVL 151

                        170
                 ....*....|..
gi 311088305 161 FVSVLIVIEIIR 172
Cdd:MTH00138 152 LLTLFVVLELTR 163
ND6 MTH00065
NADH dehydrogenase subunit 6; Provisional
 1-172 1.64e-30

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214415  Cd Length: 172  Bit Score: 108.78  E-value: 1.64e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088305   1 MIYVMFLLSVVFVLGFMSFSSKPSPIYGGVGLVVSGAVGCIIIMGFGGSFVGLMVFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00065   1 MMYLGFLGMLGLVVGLVAVASNPSPYFAALGLVLGAVCGCLVLVELGVSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088305  81 TWSSSVVVWgslLVGLIMELLVVIWVMgqdsfevVVGLDDLEDWVVFTGKEVNTVREDSLGVAALYDYVSWFMVVAGWSL 160
Cdd:MTH00065  81 AWGSWSVLV---YVLFYLLLLIVGYIL-------FGCNFSLEFLFTNYDTEFSVVGYDWGGVGLMYSSGGWFLMISGWVL 150

                        170
                 ....*....|..
gi 311088305 161 FVSVLIVIEIIR 172
Cdd:MTH00065 151 LLTLFVVLEVTR 162
ND6 MTH00115
NADH dehydrogenase subunit 6; Provisional
 1-172 1.66e-23

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214424  Cd Length: 174  Bit Score: 90.96  E-value: 1.66e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088305   1 MIYVMFLLSVVFVLGFMSFSSKPSPIYGGVGLVVSGAVGCIIIMGFGGSFVGLMVFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00115   1 MMYFVFLLGVCFVLGVVGVASNPSPYYGVVSLVLASVFGCGVLVSLGGSFVSLVLFLVYLGGMLVVFAYSVSLAADPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088305  81 TWSSSVVVWGslLVGLIMELLVVIWVMGQDSFEVVVGLDDLEDWVVFtgkevnTVREDSLGVAALYDYVSWFMVVAGWSL 160
Cdd:MTH00115  81 AWGDWGVVGY--VVGFVLVVVVVGVVVGGLWGMEGVGVVTVDSGGLF------VVRLDFSGVSLFYSSGGGGLLVCGWGL 152

                        170
                 ....*....|..
gi 311088305 161 FVSVLIVIEIIR 172
Cdd:MTH00115 153 LLTLFVVLELVR 164
ND6 MTH00214
NADH dehydrogenase subunit 6; Provisional
 1-172 3.28e-14

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214461  Cd Length: 168  Bit Score: 66.55  E-value: 3.28e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088305   1 MIYVMFLLSVVFVLGFMSFSSKPSPIYGGVGLVVSGAVGCIIIMGFGGSFVGLMVFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00214   1 MLYFVFLLMFGFLLGLMMVASSPSPYFGALGLVLLALLGCFLLLSHGNSFLGLILFLIYLGGMLVVFSYSAALAADPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088305  81 TWSSSVVVWGSLLVGLIMELLVVIWVMGQDSFEVVVGlddledwvvftgkeVNTVREDSLGVAALYDYVSWFMVVAGWSL 160
Cdd:MTH00214  81 SWGGWSVLLFFLFYLLGLGFVGFYFYGGWEMLSWMGV--------------DEANNLDLSGVSDLYSRGFFLLLLGGVVL 146

                        170
                 ....*....|..
gi 311088305 161 FVSVLIVIEIIR 172
Cdd:MTH00214 147 FLVLFVVLELVR 158
ND6 MTH00045
NADH dehydrogenase subunit 6; Validated
 1-170 3.61e-11

NADH dehydrogenase subunit 6; Validated


Pssm-ID: 177120  Cd Length: 162  Bit Score: 58.38  E-value: 3.61e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088305   1 MIYVMFLLSVVFVLGFMSFSSkpSPIYGGVGLVVSGAVGCIIIMGFGGSFVGLMVFLVYLGGMLVVFGYTTAMATEEYPe 80
Cdd:MTH00045   1 MVFYLFLILMLFGSTLVFYSL--SPYYSALGLVLVSLSGCLLLSLLGLSFLALLLLLIYMGGMLVVFVYSSALSAERYP- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088305  81 twssSVVVWGSLLVgliMELLVVIWvmgqdsfeVVVGLDDLEDWVVFTGKEVNTVREDSLGVaaLYDYVSWFMVVAGWSL 160
Cdd:MTH00045  78 ----SVSNLGEVLV---LSLLLSLW--------VFISFDNFLELSNNNWSLVSLSDLVGSSE--LYNSGGLYLLLGGFIL 140

                        170
                 ....*....|
gi 311088305 161 FVSVLIVIEI 170
Cdd:MTH00045 141 LVALVVALVI 150
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
21-170 1.96e-09

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 53.28  E-value: 1.96e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088305   21 SKPSPIYGGVGLVVSGAVGCIIIMGFGGSFVGLMVFLVYLGGMLVVFGYTTAMATEEYPETWSSSVVVWGSLLVGLIMeL 100
Cdd:pfam00499   5 TSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGLLL-L 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088305  101 LVVIWVMGQDSFEVVVglddledwvvfTGKEVNTVREDSLGVAALYDYVsWFMVVAGWSLFVSVLIVIEI 170
Cdd:pfam00499  84 ALLLLVLLSASLTPAA-----------AAAAPDVGNIEAIGELLFTDYL-LPFELASVLLLVALVGAIVL 141
ND6 MTH00212
NADH dehydrogenase subunit 6; Provisional
 5-78 1.50e-04

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214460  Cd Length: 160  Bit Score: 39.99  E-value: 1.50e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 311088305   5 MFLLSVVFVLGFMSFSSKPSPIYGGVGLVVSGAVGCIIIMGFGGSFVGLMVFLVYLGGMLVVFGYTTAMATEEY 78
Cdd:MTH00212   3 LSLLLSLLLLLMLLFPLSAHPLTLGVSLLLSSLLSCLIITMESNSWYGYILFLIYIGGLLVLFGYMVALSPNEH 76
ND6 MTH00152
NADH dehydrogenase subunit 6; Provisional
 4-74 3.06e-03

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214437  Cd Length: 163  Bit Score: 36.40  E-value: 3.06e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 311088305   4 VMFLLSVVFVLGFMSFSSKpSPIYGGVGLVVSGAVGCIIIMGFGGSFVGLMVFLVYLGGMLVVFGYTTAMA 74
Cdd:MTH00152   3 LMILLSVCFSLFLLLPLSK-QPLSLGLVLLLLSLFVCVEIGLTLSSWYGYLLFLVYVGGLLVMFAYVVSLS 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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