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Conserved domains on  [gi|311088330|gb|ADP68383|]
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NADH dehydrogenase subunit 4L (mitochondrion) [Lepilemur tymerlachsoni]

Protein Classification

NADH-ubiquinone oxidoreductase chain 4L( domain architecture ID 10009568)

NADH-ubiquinone oxidoreductase chain 4L is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) and is believed to belong to the minimal assembly required for catalysis; Complex I functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.43e-36

NADH dehydrogenase subunit 4L; Provisional


:

Pssm-ID: 177169  Cd Length: 98  Bit Score: 118.88  E-value: 1.43e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088330  1 MPSISTNITLAFTIALTGMLVFRSHLMSSLLCLEGMMLSMFILSILFIMNLHYTVSFIMPILLLVLAACEAAIGLALLVM 80
Cdd:MTH00107  1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                        90
                ....*....|....*...
gi 311088330 81 MSNTYGLDHVQNLNLLQC 98
Cdd:MTH00107 81 VSNTYGTDYVQNLNLLQC 98
 
Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.43e-36

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 118.88  E-value: 1.43e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088330  1 MPSISTNITLAFTIALTGMLVFRSHLMSSLLCLEGMMLSMFILSILFIMNLHYTVSFIMPILLLVLAACEAAIGLALLVM 80
Cdd:MTH00107  1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                        90
                ....*....|....*...
gi 311088330 81 MSNTYGLDHVQNLNLLQC 98
Cdd:MTH00107 81 VSNTYGTDYVQNLNLLQC 98
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
3-98 9.99e-13

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 58.34  E-value: 9.99e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088330   3 SISTNITLAFTIALTGMLvFRSHLMSSLLCLEGMMLSMFILSILFIMNLHYTVSFIMPILLLVLAACEAAIGLALLVMMS 82
Cdd:pfam00420  1 AYLLLSGLLFLIGLYGLL-LRRNLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIY 79

                         90
                 ....*....|....*.
gi 311088330  83 NTYGLDHVQNLNLLQC 98
Cdd:pfam00420 80 RTHGTDDVDSLNLLKG 95
NuoK COG0713
NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; ...
 12-96 3.92e-05

NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440477  Cd Length: 99  Bit Score: 38.89  E-value: 3.92e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088330 12 FTIALTGMLVfRSHLMSSLLCLEGMMLSMFILSILFIMNLHYTVSFIMPILLLVLAACEAAIGLALLVMMSNTYGLDHVQ 91
Cdd:COG0713  14 FAIGLYGVLT-RRNLIVVLMSIELMLNAVNLNLVAFSRYLGDLDGQVFALFVIAVAAAEVAVGLAIIVALYRNRGTIDVD 92


                ....*
gi 311088330 92 NLNLL 96
Cdd:COG0713  93 DLNEL 97
 
Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.43e-36

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 118.88  E-value: 1.43e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088330  1 MPSISTNITLAFTIALTGMLVFRSHLMSSLLCLEGMMLSMFILSILFIMNLHYTVSFIMPILLLVLAACEAAIGLALLVM 80
Cdd:MTH00107  1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                        90
                ....*....|....*...
gi 311088330 81 MSNTYGLDHVQNLNLLQC 98
Cdd:MTH00107 81 VSNTYGTDYVQNLNLLQC 98
ND4L MTH00126
NADH dehydrogenase subunit 4L; Provisional
 1-98 2.16e-23

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177185  Cd Length: 98  Bit Score: 85.79  E-value: 2.16e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088330  1 MPSISTNITLAFTIALTGMLVFRSHLMSSLLCLEGMMLSMFILSILFIMNLHYTVSFIMPILLLVLAACEAAIGLALLVM 80
Cdd:MTH00126  1 MTPVHFSFSSAFILGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWALQLESTSFSAAPMLLLAFSACEASAGLALLVA 80

                        90
                ....*....|....*...
gi 311088330 81 MSNTYGLDHVQNLNLLQC 98
Cdd:MTH00126 81 TARTHGTDRLQNLNLLQC 98
ND4L MTH00125
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.12e-21

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177184  Cd Length: 98  Bit Score: 81.05  E-value: 1.12e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088330  1 MPSISTNITLAFTIALTGMLVFRSHLMSSLLCLEGMMLSMFILSILFIMNLHYTVSFIMPILLLVLAACEAAIGLALLVM 80
Cdd:MTH00125  1 MTPTHFSLYTAFMLSLLGLSFHRTHLMSALLCLESMMLSLFIMLSLWPITTQTPSFTPMPIILLTFSACEAGTGLALLVA 80

                        90
                ....*....|....*...
gi 311088330 81 MSNTYGLDHVQNLNLLQC 98
Cdd:MTH00125 81 TTRTHGSDHLKNLNLLQC 98
ND4L MTH00067
NADH dehydrogenase subunit 4L; Provisional
 11-98 5.96e-18

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177139  Cd Length: 98  Bit Score: 71.94  E-value: 5.96e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088330 11 AFTIALTGMLVFRSHLMSSLLCLEGMMLSMFILSILFIMNLHYTVSFIMPILLLVLAACEAAIGLALLVMMSNTYGLDHV 90
Cdd:MTH00067 11 AFLLGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWSTQFESLSYFSLPMFMLTFSACEASTGLALMVATTRTHGTDHL 90


                ....*...
gi 311088330 91 QNLNLLQC 98
Cdd:MTH00067 91 KNLNLLQC 98
ND4L MTH00181
NADH dehydrogenase subunit 4L; Provisional
 9-96 6.83e-13

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214450  Cd Length: 93  Bit Score: 58.80  E-value: 6.83e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088330  9 TLAFTIALTGMLVFRSHLMSSLLCLEGMMLSMFILSILFIMNLHYTVSFIMPILLLVLAACEAAIGLALLVMMSNTYGLD 88
Cdd:MTH00181  6 ISAFILLLLGLSLYKTHLLSLLLCLEGMMLFLFLLLALFSLLSSSSSMLMFGLILLTFSACEAVLGLSLLVATNRTHGSD 85


                ....*...
gi 311088330 89 HVQNLNLL 96
Cdd:MTH00181 86 HLLKFNLL 93
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
3-98 9.99e-13

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 58.34  E-value: 9.99e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088330   3 SISTNITLAFTIALTGMLvFRSHLMSSLLCLEGMMLSMFILSILFIMNLHYTVSFIMPILLLVLAACEAAIGLALLVMMS 82
Cdd:pfam00420  1 AYLLLSGLLFLIGLYGLL-LRRNLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIY 79

                         90
                 ....*....|....*.
gi 311088330  83 NTYGLDHVQNLNLLQC 98
Cdd:pfam00420 80 RTHGTDDVDSLNLLKG 95
ND4L MTH00043
NADH dehydrogenase subunit 4L; Validated
 1-97 2.86e-09

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 214410  Cd Length: 98  Bit Score: 49.53  E-value: 2.86e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088330  1 MPSISTNITLAFTIALTGMLVFRSHLMSSLLCLEGMMLSMFILSILFIMNLHYTVSFIMPILLLVLAACEAAIGLALLVM 80
Cdd:MTH00043  1 MNIILIIILSSFFLGLLGILINRLHLLSILLCLELLLISLFLNISIWSLNYGNFSNLSFSLLLLTLSACEASIGLSLMVL 80

                        90
                ....*....|....*..
gi 311088330 81 MSNTYGLDHVQNLNLLQ 97
Cdd:MTH00043 81 LSRNHNSDLVASLNLLQ 97
ND4L MTH00188
NADH dehydrogenase subunit 4L; Provisional
 8-98 1.01e-07

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177237  Cd Length: 97  Bit Score: 45.74  E-value: 1.01e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088330  8 ITLAFTIALTGMLVFRSHLMSSLLCLEGMMLSMFILSILFIMNLHYtvSFIMPILLLVLAACEAAIGLALLVMMSNTYGL 87
Cdd:MTH00188  9 ILLFVVLGLFTFLLNRKHLLMLLLSLEAIMLSLFWFLLVGLSYMEK--ELYLSLVLLTFAACEASVGLALLVSLIRSHGS 86

                        90
                ....*....|.
gi 311088330 88 DHVQNLNLLQC 98
Cdd:MTH00188 87 DYVSSLNLIKC 97
ND4L MTH00149
NADH dehydrogenase subunit 4L; Provisional
 9-98 4.32e-06

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214434  Cd Length: 97  Bit Score: 41.37  E-value: 4.32e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088330  9 TLAFTIALTGMLVFRSHLMSSLLCLEGMMLSMFILSILFIMNLHYTVSFIMpiLLLVLAACEAAIGLALLVMMSNTYGLD 88
Cdd:MTH00149 10 LFGFLMGVFALLFQYKHLLSILLSLEALMLSLLVMMFSSSGLISFSSYLFL--IILTFGACEASLGLSLLVSLIRLHGND 87

                        90
                ....*....|
gi 311088330 89 HVQNLNLLQC 98
Cdd:MTH00149 88 YVSSLSSLKF 97
ND4L MTH00162
NADH dehydrogenase subunit 4L; Provisional
 12-92 1.12e-05

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177218  Cd Length: 89  Bit Score: 40.14  E-value: 1.12e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088330 12 FTIALTGMLVFRSHLMSSLLCLEGMMLSMFILSILFIMNLHYTVSFIMpiLLLVLAACEAAIGLALLVMMSNTYGLDHVQ 91
Cdd:MTH00162 11 FFSGLLVFLSKRKHLLLMLLSLEFMVLSLFFLLFLYLSFFNYELYFLL--FFLTFSVCEGALGLSILVSMIRSHGNDYFS 88


                .
gi 311088330 92 N 92
Cdd:MTH00162 89 S 89
NuoK COG0713
NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; ...
 12-96 3.92e-05

NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440477  Cd Length: 99  Bit Score: 38.89  E-value: 3.92e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088330 12 FTIALTGMLVfRSHLMSSLLCLEGMMLSMFILSILFIMNLHYTVSFIMPILLLVLAACEAAIGLALLVMMSNTYGLDHVQ 91
Cdd:COG0713  14 FAIGLYGVLT-RRNLIVVLMSIELMLNAVNLNLVAFSRYLGDLDGQVFALFVIAVAAAEVAVGLAIIVALYRNRGTIDVD 92


                ....*
gi 311088330 92 NLNLL 96
Cdd:COG0713  93 DLNEL 97
ND4L MTH00013
NADH dehydrogenase subunit 4L; Validated
 1-98 5.09e-05

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 133655  Cd Length: 97  Bit Score: 38.58  E-value: 5.09e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088330  1 MPSISTNITLAFTIALTGMLVFRSHLMSSLLCLEGMMLSMFILSILFIMNLHyTVSFIMPILLLVLAACEAAIGLALLVM 80
Cdd:MTH00013  1 MMSPLFILSISPFISMFNLSLQRKHLLMSLLSLEAMILSLALFIPLSLMFAN-QVNGMLAIVLLTFGACEASLGLSLLVL 79

                        90
                ....*....|....*...
gi 311088330 81 MSNTYGLDHVQNLNLLQC 98
Cdd:MTH00013 80 MTRSYGNDMLKSLTSNKC 97
PRK05715 PRK05715
NADH-quinone oxidoreductase subunit NuoK;
12-96 1.13e-04

NADH-quinone oxidoreductase subunit NuoK;


Pssm-ID: 180218  Cd Length: 100  Bit Score: 37.85  E-value: 1.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088330  12 FTIALTGMLVFRSHLMSsLLCLEGMMLSMFILSILFIMNLHYTVSFIMPILLLVLAACEAAIGLALLVMMSNTYGLDHVQ 91
Cdd:PRK05715  15 FCIGLVGLLLRRNAIVV-LMSIELMLNAVNLNFVAFSSYLGDLDGQVFAFFVITVAAAEAAIGLAILLQLYRNRGTIDVD 93


                 ....*
gi 311088330  92 NLNLL 96
Cdd:PRK05715  94 DLNEL 98
ND4L MTH00180
NADH dehydrogenase subunit 4L; Provisional
 12-97 7.86e-04

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177231  Cd Length: 99  Bit Score: 35.39  E-value: 7.86e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088330 12 FTIALTGMLVFRSHLMSSLLCLEGMMLSMFILSILFIMNLHYTVSFIMPILLLVLAACEAAIGLALLVMMSNTYGLDHVQ 91
Cdd:MTH00180 13 FILGVLGIVLNRSNLIIMLMSIELMLLAISLLFLINSVAIDNLIGQIFTIMILTVAAAESAIGLAILVAYYRIRGTIAVK 92


                ....*.
gi 311088330 92 NLNLLQ 97
Cdd:MTH00180 93 SLNLLR 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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