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Conserved domains on  [gi|311088417|gb|ADP68464|]
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NADH dehydrogenase subunit 6 (mitochondrion) [Lepilemur microdon]

Protein Classification

NADH dehydrogenase subunit 6( domain architecture ID 10009569)

NADH dehydrogenase subunit 6 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-171 1.76e-74

NADH dehydrogenase subunit 6; Provisional


:

Pssm-ID: 214421  Cd Length: 175  Bit Score: 220.83  E-value: 1.76e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088417   1 MIYMMFLLSVVFVLGFMSFSSKPSPIYGGVGLVISGAVGCMIVMGFGGSFVGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088417  81 TWGSSVVVWGSLLTGLIMELLMVMWVMGQSSFEVVVGPDDLEDWVVL-GKEVCVVREDSLGVAALYNYVNWFMVVAGWSL 159
Cdd:MTH00109  82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYdTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                        170
                 ....*....|..
gi 311088417 160 FVSVLIVIEIIR 171
Cdd:MTH00109 162 FIGVFVIIEITR 173
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-171 1.76e-74

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 220.83  E-value: 1.76e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088417   1 MIYMMFLLSVVFVLGFMSFSSKPSPIYGGVGLVISGAVGCMIVMGFGGSFVGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088417  81 TWGSSVVVWGSLLTGLIMELLMVMWVMGQSSFEVVVGPDDLEDWVVL-GKEVCVVREDSLGVAALYNYVNWFMVVAGWSL 159
Cdd:MTH00109  82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYdTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                        170
                 ....*....|..
gi 311088417 160 FVSVLIVIEIIR 171
Cdd:MTH00109 162 FIGVFVIIEITR 173
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
21-169 1.58e-09

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 53.28  E-value: 1.58e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088417   21 SKPSPIYGGVGLVISGAVGCMIVMGFGGSFVGLMVFLIYLGGMLVVFGYTTAMATEEYPETWGSSVVVWGSLLTGLIMEL 100
Cdd:pfam00499   5 TSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGLLLLA 84

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 311088417  101 LMVMWVMGQSSFEVVVGPDdledwvvlgkeVCVVREDSLGVAALYNYVnWFMVVAGWSLFVSVLIVIEI 169
Cdd:pfam00499  85 LLLLVLLSASLTPAAAAAA-----------PDVGNIEAIGELLFTDYL-LPFELASVLLLVALVGAIVL 141
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-171 1.76e-74

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 220.83  E-value: 1.76e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088417   1 MIYMMFLLSVVFVLGFMSFSSKPSPIYGGVGLVISGAVGCMIVMGFGGSFVGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088417  81 TWGSSVVVWGSLLTGLIMELLMVMWVMGQSSFEVVVGPDDLEDWVVL-GKEVCVVREDSLGVAALYNYVNWFMVVAGWSL 159
Cdd:MTH00109  82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYdTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                        170
                 ....*....|..
gi 311088417 160 FVSVLIVIEIIR 171
Cdd:MTH00109 162 FIGVFVIIEITR 173
ND6 MTH00138
NADH dehydrogenase subunit 6; Provisional
 1-171 1.84e-34

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 177196  Cd Length: 173  Bit Score: 119.09  E-value: 1.84e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088417   1 MIYMMFLLSVVFVLGFMSFSSKPSPIYGGVGLVISGAVGCMIVMGFGGSFVGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00138   1 MTYLMSLFLLGLVLGLVAVASNPSPYFAALGLVVVAGVGCGVLVGHGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088417  81 TWGSSVVVwgslltglimeLLMVMWVMGQSSFEVVVGPDDLE-DWVVLG--KEVCVVREDSLGVAALYNYVNWFMVVAGW 157
Cdd:MTH00138  81 SWGSWSVL-----------GYVVGYLVGVVLAAGLFWGGWYEgSWVVVDelKEFSVLRGDVGGVALMYSSGGGMLVICAW 149

                        170
                 ....*....|....
gi 311088417 158 SLFVSVLIVIEIIR 171
Cdd:MTH00138 150 VLLLTLFVVLELTR 163
ND6 MTH00065
NADH dehydrogenase subunit 6; Provisional
 1-171 1.64e-30

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214415  Cd Length: 172  Bit Score: 108.78  E-value: 1.64e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088417   1 MIYMMFLLSVVFVLGFMSFSSKPSPIYGGVGLVISGAVGCMIVMGFGGSFVGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00065   1 MMYLGFLGMLGLVVGLVAVASNPSPYFAALGLVLGAVCGCLVLVELGVSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088417  81 TWGSSVVVWGSLLTGLimeLLMVMWVMGQSSFEVvvgpddLEDWVVLGKEVCVVREDSLGVAALYNYVNWFMVVAGWSLF 160
Cdd:MTH00065  81 AWGSWSVLVYVLFYLL---LLIVGYILFGCNFSL------EFLFTNYDTEFSVVGYDWGGVGLMYSSGGWFLMISGWVLL 151

                        170
                 ....*....|.
gi 311088417 161 VSVLIVIEIIR 171
Cdd:MTH00065 152 LTLFVVLEVTR 162
ND6 MTH00115
NADH dehydrogenase subunit 6; Provisional
 1-171 3.00e-24

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214424  Cd Length: 174  Bit Score: 92.89  E-value: 3.00e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088417   1 MIYMMFLLSVVFVLGFMSFSSKPSPIYGGVGLVISGAVGCMIVMGFGGSFVGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00115   1 MMYFVFLLGVCFVLGVVGVASNPSPYYGVVSLVLASVFGCGVLVSLGGSFVSLVLFLVYLGGMLVVFAYSVSLAADPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088417  81 TWGSSVVVWGSLLTGLIMELLMVMWVMGQSSFEVVVGpddledwVVLGKEVCVVREDSLGVAALYNYVNWFMVVAGWSLF 160
Cdd:MTH00115  81 AWGDWGVVGYVVGFVLVVVVVGVVVGGLWGMEGVGVV-------TVDSGGLFVVRLDFSGVSLFYSSGGGGLLVCGWGLL 153

                        170
                 ....*....|.
gi 311088417 161 VSVLIVIEIIR 171
Cdd:MTH00115 154 LTLFVVLELVR 164
ND6 MTH00214
NADH dehydrogenase subunit 6; Provisional
 1-171 1.57e-14

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214461  Cd Length: 168  Bit Score: 67.32  E-value: 1.57e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088417   1 MIYMMFLLSVVFVLGFMSFSSKPSPIYGGVGLVISGAVGCMIVMGFGGSFVGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00214   1 MLYFVFLLMFGFLLGLMMVASSPSPYFGALGLVLLALLGCFLLLSHGNSFLGLILFLIYLGGMLVVFSYSAALAADPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088417  81 TWGSSVVVWGSLLTGLIMELLMVMWVMGQSSFEVVVGpddledwvvlgkeVCVVREDSLGVAALYNYVNWFMVVAGWSLF 160
Cdd:MTH00214  81 SWGGWSVLLFFLFYLLGLGFVGFYFYGGWEMLSWMGV-------------DEANNLDLSGVSDLYSRGFFLLLLGGVVLF 147

                        170
                 ....*....|.
gi 311088417 161 VSVLIVIEIIR 171
Cdd:MTH00214 148 LVLFVVLELVR 158
ND6 MTH00045
NADH dehydrogenase subunit 6; Validated
 4-169 3.07e-12

NADH dehydrogenase subunit 6; Validated


Pssm-ID: 177120  Cd Length: 162  Bit Score: 61.07  E-value: 3.07e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088417   4 MMFLLSVVFVLG---FMSFSSkpSPIYGGVGLVISGAVGCMIVMGFGGSFVGLMVFLIYLGGMLVVFGYTTAMATEEYPe 80
Cdd:MTH00045   1 MVFYLFLILMLFgstLVFYSL--SPYYSALGLVLVSLSGCLLLSLLGLSFLALLLLLIYMGGMLVVFVYSSALSAERYP- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088417  81 twgsSVVVWGSLltgLIMELLMVMWvmgqssfeVVVGPDDLEDWVVLGKEVcVVREDSLGVAALYNYVNWFMVVAGWSLF 160
Cdd:MTH00045  78 ----SVSNLGEV---LVLSLLLSLW--------VFISFDNFLELSNNNWSL-VSLSDLVGSSELYNSGGLYLLLGGFILL 141


                 ....*....
gi 311088417 161 VSVLIVIEI 169
Cdd:MTH00045 142 VALVVALVI 150
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
21-169 1.58e-09

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 53.28  E-value: 1.58e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311088417   21 SKPSPIYGGVGLVISGAVGCMIVMGFGGSFVGLMVFLIYLGGMLVVFGYTTAMATEEYPETWGSSVVVWGSLLTGLIMEL 100
Cdd:pfam00499   5 TSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGLLLLA 84

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 311088417  101 LMVMWVMGQSSFEVVVGPDdledwvvlgkeVCVVREDSLGVAALYNYVnWFMVVAGWSLFVSVLIVIEI 169
Cdd:pfam00499  85 LLLLVLLSASLTPAAAAAA-----------PDVGNIEAIGELLFTDYL-LPFELASVLLLVALVGAIVL 141
ND6 MTH00212
NADH dehydrogenase subunit 6; Provisional
 4-78 1.30e-04

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214460  Cd Length: 160  Bit Score: 40.37  E-value: 1.30e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 311088417   4 MMFLLSVVFVLGFMsFSSKPSPIYGGVGLVISGAVGCMIVMGFGGSFVGLMVFLIYLGGMLVVFGYTTAMATEEY 78
Cdd:MTH00212   3 LSLLLSLLLLLMLL-FPLSAHPLTLGVSLLLSSLLSCLIITMESNSWYGYILFLIYIGGLLVLFGYMVALSPNEH 76
ND6 MTH00152
NADH dehydrogenase subunit 6; Provisional
 4-74 3.29e-03

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214437  Cd Length: 163  Bit Score: 36.40  E-value: 3.29e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 311088417   4 MMFLLSVVFVLGFMSFSSKpSPIYGGVGLVISGAVGCMIVMGFGGSFVGLMVFLIYLGGMLVVFGYTTAMA 74
Cdd:MTH00152   3 LMILLSVCFSLFLLLPLSK-QPLSLGLVLLLLSLFVCVEIGLTLSSWYGYLLFLVYVGGLLVMFAYVVSLS 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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