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Conserved domains on  [gi|315191818|gb|ADT90351|]
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hypothetical protein, partial [Xenopus laevis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF5614 super family cl39806
Family of unknown function (DUF5614); This is an N-terminal domain found in C7orf25 protein ...
 1-109 1.40e-71

Family of unknown function (DUF5614); This is an N-terminal domain found in C7orf25 protein UPF0415. It is distantly related to the PD-(D/E)XK nucleases.


The actual alignment was detected with superfamily member pfam18474:

Pssm-ID: 436527  Cd Length: 221  Bit Score: 215.45  E-value: 1.40e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315191818    1 NGGHTWVKAIGRKAEALHNIWLGRGQYGDKSVIEQAEDYLLASSQQLVQYSSPHIIFAFYNSVSKPMAEKLKEIGISVRG 80
Cdd:pfam18474 111 NGGHTWVKAIGRKAEALHNIWQGRGQYGDKSVVEQAEDFLQASRQQPVQYSNPHIIFAFYNGVSSPMADRLKEMGISVRG 190

                          90       100       110
                  ....*....|....*....|....*....|.
gi 315191818   81 DIVAVNTSQENLPEENYLSGS--ESDCDGDD 109
Cdd:pfam18474 191 DIVAVNSVAGGPEEEEALSGSdeESDEEGPE 221
DUF1308 super family cl15654
Protein of unknown function (DUF1308); This is a domain of unknown function found on the ...
 141-177 2.51e-18

Protein of unknown function (DUF1308); This is a domain of unknown function found on the C-terminal of C7orf25 protein UPF0415. The C-terminal domain is homologous to the known PIN-like domains. The PIN-like domain is widespread among eukaryotes, including animals, plants, and fungi, but also present in some cyanobacteria, Deinococcus, and dsDNA viruses from the Mimiviridae family. The domain retains up to four potential catalytic residues, thus, depending on the protein is predicted to be an active or inactive nuclease and in a majority of the family members, the PIN-like domain is N-terminally fused with a potentially active PD-(D/E)XK-like domain pfam18474.


The actual alignment was detected with superfamily member pfam07000:

Pssm-ID: 399767  Cd Length: 163  Bit Score: 77.31  E-value: 2.51e-18
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 315191818  141 VNLDITTLITYVSALSHGGCHWLFKEKVLTEQAAQER 177
Cdd:pfam07000   1 LNLDVTTLLAYVSNLTNGGCNFVFKEPLLTEQAEWER 37
 
Name Accession Description Interval E-value
DUF5614 pfam18474
Family of unknown function (DUF5614); This is an N-terminal domain found in C7orf25 protein ...
 1-109 1.40e-71

Family of unknown function (DUF5614); This is an N-terminal domain found in C7orf25 protein UPF0415. It is distantly related to the PD-(D/E)XK nucleases.


Pssm-ID: 436527  Cd Length: 221  Bit Score: 215.45  E-value: 1.40e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315191818    1 NGGHTWVKAIGRKAEALHNIWLGRGQYGDKSVIEQAEDYLLASSQQLVQYSSPHIIFAFYNSVSKPMAEKLKEIGISVRG 80
Cdd:pfam18474 111 NGGHTWVKAIGRKAEALHNIWQGRGQYGDKSVVEQAEDFLQASRQQPVQYSNPHIIFAFYNGVSSPMADRLKEMGISVRG 190

                          90       100       110
                  ....*....|....*....|....*....|.
gi 315191818   81 DIVAVNTSQENLPEENYLSGS--ESDCDGDD 109
Cdd:pfam18474 191 DIVAVNSVAGGPEEEEALSGSdeESDEEGPE 221
DUF1308 pfam07000
Protein of unknown function (DUF1308); This is a domain of unknown function found on the ...
 141-177 2.51e-18

Protein of unknown function (DUF1308); This is a domain of unknown function found on the C-terminal of C7orf25 protein UPF0415. The C-terminal domain is homologous to the known PIN-like domains. The PIN-like domain is widespread among eukaryotes, including animals, plants, and fungi, but also present in some cyanobacteria, Deinococcus, and dsDNA viruses from the Mimiviridae family. The domain retains up to four potential catalytic residues, thus, depending on the protein is predicted to be an active or inactive nuclease and in a majority of the family members, the PIN-like domain is N-terminally fused with a potentially active PD-(D/E)XK-like domain pfam18474.


Pssm-ID: 399767  Cd Length: 163  Bit Score: 77.31  E-value: 2.51e-18
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 315191818  141 VNLDITTLITYVSALSHGGCHWLFKEKVLTEQAAQER 177
Cdd:pfam07000   1 LNLDVTTLLAYVSNLTNGGCNFVFKEPLLTEQAEWER 37
 
Name Accession Description Interval E-value
DUF5614 pfam18474
Family of unknown function (DUF5614); This is an N-terminal domain found in C7orf25 protein ...
 1-109 1.40e-71

Family of unknown function (DUF5614); This is an N-terminal domain found in C7orf25 protein UPF0415. It is distantly related to the PD-(D/E)XK nucleases.


Pssm-ID: 436527  Cd Length: 221  Bit Score: 215.45  E-value: 1.40e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315191818    1 NGGHTWVKAIGRKAEALHNIWLGRGQYGDKSVIEQAEDYLLASSQQLVQYSSPHIIFAFYNSVSKPMAEKLKEIGISVRG 80
Cdd:pfam18474 111 NGGHTWVKAIGRKAEALHNIWQGRGQYGDKSVVEQAEDFLQASRQQPVQYSNPHIIFAFYNGVSSPMADRLKEMGISVRG 190

                          90       100       110
                  ....*....|....*....|....*....|.
gi 315191818   81 DIVAVNTSQENLPEENYLSGS--ESDCDGDD 109
Cdd:pfam18474 191 DIVAVNSVAGGPEEEEALSGSdeESDEEGPE 221
DUF1308 pfam07000
Protein of unknown function (DUF1308); This is a domain of unknown function found on the ...
 141-177 2.51e-18

Protein of unknown function (DUF1308); This is a domain of unknown function found on the C-terminal of C7orf25 protein UPF0415. The C-terminal domain is homologous to the known PIN-like domains. The PIN-like domain is widespread among eukaryotes, including animals, plants, and fungi, but also present in some cyanobacteria, Deinococcus, and dsDNA viruses from the Mimiviridae family. The domain retains up to four potential catalytic residues, thus, depending on the protein is predicted to be an active or inactive nuclease and in a majority of the family members, the PIN-like domain is N-terminally fused with a potentially active PD-(D/E)XK-like domain pfam18474.


Pssm-ID: 399767  Cd Length: 163  Bit Score: 77.31  E-value: 2.51e-18
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 315191818  141 VNLDITTLITYVSALSHGGCHWLFKEKVLTEQAAQER 177
Cdd:pfam07000   1 LNLDVTTLLAYVSNLTNGGCNFVFKEPLLTEQAEWER 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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