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Conserved domains on  [gi|315192513|gb|ADT90642|]
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Pcdh1, partial [Xenopus laevis]

Protein Classification

cadherin repeat domain-containing protein( domain architecture ID 10638917)

cadherin repeat domain-containing protein similar to cadherins, which are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172|18430161
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 48-135 9.20e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 81.59  E-value: 9.20e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315192513  48 SYKYLTPE-THPGTQVNWVRAEDMDTGVNAELEYSIASGNPFQLFQISPNNGEVTLEKTIIRKHYGLHRLVVRVNDKGKP 126
Cdd:cd11304    1 SYEVSVPEnAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80


                 ....*....
gi 315192513 127 SRHGTALVH 135
Cdd:cd11304   81 PLSSTATVT 89
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1-39 1.71e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 56.97  E-value: 1.71e-11
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 315192513     1 REHQSTYTFRLKAVDGGDPPRSSYVGVTINVLDENDNAP 39
Cdd:smart00112  43 REEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Protocadherin super family cl07119
Protocadherin; The structure of protocadherins is similar to that of classic cadherins ...
 141-169 8.54e-08

Protocadherin; The structure of protocadherins is similar to that of classic cadherins (pfam00028), but particularly on the cytoplasmic domains they also have some unique features. They are expressed in a variety of organizms and are found in high concentrations in the brain where they seem to be localized mainly at cell-cell contact sites. Their expression seems to be developmentally regulated.


The actual alignment was detected with superfamily member pfam08374:

Pssm-ID: 462451  Cd Length: 217  Bit Score: 49.74  E-value: 8.54e-08
                          10        20
                  ....*....|....*....|....*....
gi 315192513  141 TLTNQTFVETLLGHSQDTPLDIDIAGDPE 169
Cdd:pfam08374   1 SLANATLVEELVRRSLETPLDRDIAGDPD 29
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 48-135 9.20e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 81.59  E-value: 9.20e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315192513  48 SYKYLTPE-THPGTQVNWVRAEDMDTGVNAELEYSIASGNPFQLFQISPNNGEVTLEKTIIRKHYGLHRLVVRVNDKGKP 126
Cdd:cd11304    1 SYEVSVPEnAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80


                 ....*....
gi 315192513 127 SRHGTALVH 135
Cdd:cd11304   81 PLSSTATVT 89
Cadherin pfam00028
Cadherin domain;
54-138 1.83e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 67.71  E-value: 1.83e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315192513   54 PET-HPGTQVNWVRAEDMDTGVNAELEYSIASGNPFQLFQISPNNGEVTLEKTIIRKHYGLHRLVVRVNDKGKPSRHGTA 132
Cdd:pfam00028   6 PENaPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSSTA 85


                  ....*.
gi 315192513  133 LVHFYI 138
Cdd:pfam00028  86 TVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 66-135 4.50e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 63.91  E-value: 4.50e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315192513    66 RAEDMDTGVNAELEYSIASGNPFQLFQISPNNGEVTLEKTIIRKHYGLHRLVVRVNDKGKPSRHGTALVH 135
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVT 70
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1-39 1.71e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 56.97  E-value: 1.71e-11
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 315192513     1 REHQSTYTFRLKAVDGGDPPRSSYVGVTINVLDENDNAP 39
Cdd:smart00112  43 REEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1-37 9.44e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 55.40  E-value: 9.44e-11
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 315192513   1 REHQSTYTFRLKAVDGGDPPRSSYVGVTINVLDENDN 37
Cdd:cd11304   62 REEQSSYTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
Protocadherin pfam08374
Protocadherin; The structure of protocadherins is similar to that of classic cadherins ...
 141-169 8.54e-08

Protocadherin; The structure of protocadherins is similar to that of classic cadherins (pfam00028), but particularly on the cytoplasmic domains they also have some unique features. They are expressed in a variety of organizms and are found in high concentrations in the brain where they seem to be localized mainly at cell-cell contact sites. Their expression seems to be developmentally regulated.


Pssm-ID: 462451  Cd Length: 217  Bit Score: 49.74  E-value: 8.54e-08
                          10        20
                  ....*....|....*....|....*....
gi 315192513  141 TLTNQTFVETLLGHSQDTPLDIDIAGDPE 169
Cdd:pfam08374   1 SLANATLVEELVRRSLETPLDRDIAGDPD 29
Cadherin pfam00028
Cadherin domain;
1-32 3.88e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 40.36  E-value: 3.88e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 315192513    1 REHQSTYTFRLKAVDGGDPPRSSYVGVTINVL 32
Cdd:pfam00028  61 RESIGEYELTVEATDSGGPPLSSTATVTITVL 92
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 48-135 9.20e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 81.59  E-value: 9.20e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315192513  48 SYKYLTPE-THPGTQVNWVRAEDMDTGVNAELEYSIASGNPFQLFQISPNNGEVTLEKTIIRKHYGLHRLVVRVNDKGKP 126
Cdd:cd11304    1 SYEVSVPEnAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80


                 ....*....
gi 315192513 127 SRHGTALVH 135
Cdd:cd11304   81 PLSSTATVT 89
Cadherin pfam00028
Cadherin domain;
54-138 1.83e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 67.71  E-value: 1.83e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315192513   54 PET-HPGTQVNWVRAEDMDTGVNAELEYSIASGNPFQLFQISPNNGEVTLEKTIIRKHYGLHRLVVRVNDKGKPSRHGTA 132
Cdd:pfam00028   6 PENaPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSSTA 85


                  ....*.
gi 315192513  133 LVHFYI 138
Cdd:pfam00028  86 TVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 66-135 4.50e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 63.91  E-value: 4.50e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315192513    66 RAEDMDTGVNAELEYSIASGNPFQLFQISPNNGEVTLEKTIIRKHYGLHRLVVRVNDKGKPSRHGTALVH 135
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVT 70
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1-39 1.71e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 56.97  E-value: 1.71e-11
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 315192513     1 REHQSTYTFRLKAVDGGDPPRSSYVGVTINVLDENDNAP 39
Cdd:smart00112  43 REEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1-37 9.44e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 55.40  E-value: 9.44e-11
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 315192513   1 REHQSTYTFRLKAVDGGDPPRSSYVGVTINVLDENDN 37
Cdd:cd11304   62 REEQSSYTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
Protocadherin pfam08374
Protocadherin; The structure of protocadherins is similar to that of classic cadherins ...
 141-169 8.54e-08

Protocadherin; The structure of protocadherins is similar to that of classic cadherins (pfam00028), but particularly on the cytoplasmic domains they also have some unique features. They are expressed in a variety of organizms and are found in high concentrations in the brain where they seem to be localized mainly at cell-cell contact sites. Their expression seems to be developmentally regulated.


Pssm-ID: 462451  Cd Length: 217  Bit Score: 49.74  E-value: 8.54e-08
                          10        20
                  ....*....|....*....|....*....
gi 315192513  141 TLTNQTFVETLLGHSQDTPLDIDIAGDPE 169
Cdd:pfam08374   1 SLANATLVEELVRRSLETPLDRDIAGDPD 29
Cadherin pfam00028
Cadherin domain;
1-32 3.88e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 40.36  E-value: 3.88e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 315192513    1 REHQSTYTFRLKAVDGGDPPRSSYVGVTINVL 32
Cdd:pfam00028  61 RESIGEYELTVEATDSGGPPLSSTATVTITVL 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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