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Conserved domains on  [gi|350430929|gb|AEQ28432|]
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NADH dehydrogenase subunit 2, partial (mitochondrion) [Hapalopsittaca melanotis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND2 super family cl33352
NADH dehydrogenase subunit 2; Provisional
 1-342 4.36e-85

NADH dehydrogenase subunit 2; Provisional


The actual alignment was detected with superfamily member MTH00112:

Pssm-ID: 214423 [Multi-domain]  Cd Length: 346  Bit Score: 260.53  E-value: 4.36e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350430929   1 TKLISTMSILLGTMVTITSNHWAMAWAGLEINTLSIIPMISKSHHPRAIEAATKYFLVQAAASTLVLFSSTVNAQHTGQW 80
Cdd:MTH00112   5 AKLIITTSLILGTIITISSNHWLMAWTGLEINTLAIIPLISKPHHPRATEAATKYFLTQAAASALILFSSTTNAWNTGQW 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350430929  81 DITQLTYPPACVLLTTAIAIKLGLTPFHFWFPEVLQGSSL**************************************** 160
Cdd:MTH00112  85 DITQLTNPTSCTLLTLALAMKLGLAPFHFWLPEVLQGSTTTTALILSTWQKLAPLTLLLMTSNSLNPTLLLTLAILSTLI 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350430929 161 ***********************************************TSSIFLTLHTTNTLKLSTLMTSWTKTPMLNTTL 240
Cdd:MTH00112 165 GGWGGLNQTQLRKIMAFSSIAHLGWMIAIITYSPKLTLLTFYIYILMTTPMFLTLNTTSTKTLKDMMTSWTKSPTLNTTL 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350430929 241 MLTLLSLSGLPPLTGFLPKWLIMQELIEQETTTTTTIISMLSLLGLFFYLRLAYCSTITLPPNPSSKIKQWFTKNPTSPL 320
Cdd:MTH00112 245 MLTLLSLAGLPPLTGFMPKWLILQELTKQNMTPTATIMAMLSLLSLFFYLRLTYISTITLPPNTTNMMMKWRTKPKKNTL 324

                        330       340
                 ....*....|....*....|..
gi 350430929 321 ISTLTSLSILLLPLSPMILTIT 342
Cdd:MTH00112 325 TATLTTLSTLLLPLSPMILTII 346
 
Name Accession Description Interval E-value
ND2 MTH00112
NADH dehydrogenase subunit 2; Provisional
 1-342 4.36e-85

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214423 [Multi-domain]  Cd Length: 346  Bit Score: 260.53  E-value: 4.36e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350430929   1 TKLISTMSILLGTMVTITSNHWAMAWAGLEINTLSIIPMISKSHHPRAIEAATKYFLVQAAASTLVLFSSTVNAQHTGQW 80
Cdd:MTH00112   5 AKLIITTSLILGTIITISSNHWLMAWTGLEINTLAIIPLISKPHHPRATEAATKYFLTQAAASALILFSSTTNAWNTGQW 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350430929  81 DITQLTYPPACVLLTTAIAIKLGLTPFHFWFPEVLQGSSL**************************************** 160
Cdd:MTH00112  85 DITQLTNPTSCTLLTLALAMKLGLAPFHFWLPEVLQGSTTTTALILSTWQKLAPLTLLLMTSNSLNPTLLLTLAILSTLI 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350430929 161 ***********************************************TSSIFLTLHTTNTLKLSTLMTSWTKTPMLNTTL 240
Cdd:MTH00112 165 GGWGGLNQTQLRKIMAFSSIAHLGWMIAIITYSPKLTLLTFYIYILMTTPMFLTLNTTSTKTLKDMMTSWTKSPTLNTTL 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350430929 241 MLTLLSLSGLPPLTGFLPKWLIMQELIEQETTTTTTIISMLSLLGLFFYLRLAYCSTITLPPNPSSKIKQWFTKNPTSPL 320
Cdd:MTH00112 245 MLTLLSLAGLPPLTGFMPKWLILQELTKQNMTPTATIMAMLSLLSLFFYLRLTYISTITLPPNTTNMMMKWRTKPKKNTL 324

                        330       340
                 ....*....|....*....|..
gi 350430929 321 ISTLTSLSILLLPLSPMILTIT 342
Cdd:MTH00112 325 TATLTTLSTLLLPLSPMILTII 346
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 6-119 1.11e-12

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 68.60  E-value: 1.11e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350430929   6 TMSILLGTMVTITSNHWAMAWAGLEINTLSIIPMIS-KSHHPRAIEAATKYFLVQAAASTLVLF--------SSTVN--- 73
Cdd:COG1007  108 LLFATLGMMLMASANDLLTLFLGLELLSLSLYVLVAfRRDDRRSSEAALKYFLLGALSSGFLLYgisllygaTGSLNlag 187

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 350430929  74 -AQHTGQWDITQLTYPPACVLLTTAIAIKLGLTPFHFWFPEVLQGSS 119
Cdd:COG1007  188 iAAALAAGGANSPLLLLGLVLVLAGLAFKLSAVPFHMWTPDVYEGAP 234
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 9-118 8.43e-07

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 50.33  E-value: 8.43e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350430929    9 ILLGTMVTITSNHWAMAWAGLEINTLSI-IPMISKSHHPRAIEAATKYFLVQAAASTLVLFSSTV--------------N 73
Cdd:TIGR01770 111 ALLGIFLLVSSNDLLSIYLGLELQSLCFyVLAGLKRKSRFSTEAGLKYFILGAFSSGLLLFGISLiygftgslnfedllL 190

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 350430929   74 AQHTGQWDITQLTYppACVLLTTAIAIKLGLTPFHFWFPEVLQGS 118
Cdd:TIGR01770 191 FLSNGMLNISLLLL--GIVLILVGLLFKLSAVPFHMWVPDVYEGA 233
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 19-119 5.18e-06

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 47.31  E-value: 5.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350430929   19 SNHWAMAWAGLEINTLSIIPMI-SKSHHPRAIEAATKYFLVQAAASTLVLFSSTVNAQHTGQWDITQL-TYPPAC----- 91
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLLIgYWGKSPRSSEAGMKYFLLTLLGSSILLFGISLMYNYTGTLSFDELsKALTGGlnssg 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 350430929   92 -----VLLTTAIAIKLGLTPFHFWFPEVLQGSS 119
Cdd:pfam00361  81 llllfLLILVGFLFKSAQVPFHTWLPDAYEGAP 113
 
Name Accession Description Interval E-value
ND2 MTH00112
NADH dehydrogenase subunit 2; Provisional
 1-342 4.36e-85

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214423 [Multi-domain]  Cd Length: 346  Bit Score: 260.53  E-value: 4.36e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350430929   1 TKLISTMSILLGTMVTITSNHWAMAWAGLEINTLSIIPMISKSHHPRAIEAATKYFLVQAAASTLVLFSSTVNAQHTGQW 80
Cdd:MTH00112   5 AKLIITTSLILGTIITISSNHWLMAWTGLEINTLAIIPLISKPHHPRATEAATKYFLTQAAASALILFSSTTNAWNTGQW 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350430929  81 DITQLTYPPACVLLTTAIAIKLGLTPFHFWFPEVLQGSSL**************************************** 160
Cdd:MTH00112  85 DITQLTNPTSCTLLTLALAMKLGLAPFHFWLPEVLQGSTTTTALILSTWQKLAPLTLLLMTSNSLNPTLLLTLAILSTLI 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350430929 161 ***********************************************TSSIFLTLHTTNTLKLSTLMTSWTKTPMLNTTL 240
Cdd:MTH00112 165 GGWGGLNQTQLRKIMAFSSIAHLGWMIAIITYSPKLTLLTFYIYILMTTPMFLTLNTTSTKTLKDMMTSWTKSPTLNTTL 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350430929 241 MLTLLSLSGLPPLTGFLPKWLIMQELIEQETTTTTTIISMLSLLGLFFYLRLAYCSTITLPPNPSSKIKQWFTKNPTSPL 320
Cdd:MTH00112 245 MLTLLSLAGLPPLTGFMPKWLILQELTKQNMTPTATIMAMLSLLSLFFYLRLTYISTITLPPNTTNMMMKWRTKPKKNTL 324

                        330       340
                 ....*....|....*....|..
gi 350430929 321 ISTLTSLSILLLPLSPMILTIT 342
Cdd:MTH00112 325 TATLTTLSTLLLPLSPMILTII 346
ND2 MTH00070
NADH dehydrogenase subunit 2; Provisional
 8-319 3.27e-62

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177142 [Multi-domain]  Cd Length: 346  Bit Score: 201.69  E-value: 3.27e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350430929   8 SILLGTMVTITSNHWAMAWAGLEINTLSIIPMISKSHHPRAIEAATKYFLVQAAASTLVLFSSTVNAQHTGQWDITQLTY 87
Cdd:MTH00070  12 SLALGTMITLSSNHWFLAWMGLEINTLAIIPLMTKTHHPRATEAATKYFLTQASASALILFSSTINAWFTGEWTIMNMQT 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350430929  88 PPACVLLTTAIAIKLGLTPFHFWFPEVLQGSSL*********************************************** 167
Cdd:MTH00070  92 PLPTIMLTIALMMKLGIAPFHFWLPEVLQGLDLTTGLILSTWQKLAPMALLIQISHLLNSNLLIIMGLLSTLIGGWGGLN 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350430929 168 ****************************************TSSIFLTLHTTNTLKLSTLMTSWTKTPMLNTTLMLTLLSL 247
Cdd:MTH00070 172 QTQLRKIMAYSSIAHLGWMIIILTFSPHLTLLNLLIYLIMTSSMFLMLMNLNSTNINKLSSSWSKNPTLTSMMMLTLLSL 251

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 350430929 248 SGLPPLTGFLPKWLIMQELIEQETTTTTTIISMLSLLGLFFYLRLAYCSTITLPPNPSSKIKQWFTKNPTSP 319
Cdd:MTH00070 252 GGLPPTTGFIPKWLILQELTKQNLTTLATLMALSALLSLFFYLRLSYAMSLTTSPNTSNSKLYWRFKNKTNN 323
ND2 MTH00135
NADH dehydrogenase subunit 2; Provisional
 7-316 2.80e-54

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177193 [Multi-domain]  Cd Length: 347  Bit Score: 181.16  E-value: 2.80e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350430929   7 MSILLGTMVTITSNHWAMAWAGLEINTLSIIPMISKSHHPRAIEAATKYFLVQAAASTLVLFSSTVNAQHTGQWDITQLT 86
Cdd:MTH00135  11 FSLGLGTTLTFASSHWLLAWMGLEINTLAIIPLMAQHHHPRAVEATTKYFLTQATAAAMILFASTTNAWLTGQWDIQQMS 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350430929  87 YPPACVLLTTAIAIKLGLTPFHFWFPEVLQGSSL********************************************** 166
Cdd:MTH00135  91 HPLPTTMITLALALKIGLAPLHFWLPEVLQGLDL-TTGLILSTWQKLAPFALILQIAPTNPTLLITLGLTSTLVGGWGGL 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350430929 167 *****************************************TSSIFLTLHTTNTLKLSTLMTSWTKTPMLNTTLMLTLLS 246
Cdd:MTH00135 170 NQTQLRKILAYSSIAHLGWMILVLQFSPSLTLLALLTYIIMTSSAFLTFKLNSSTKINTLATSWTKAPALTALTPLILLS 249

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350430929 247 LSGLPPLTGFLPKWLIMQELIEQETTTTTTIISMLSLLGLFFYLRLAYCSTITLPPNPSSKIKQWFTKNP 316
Cdd:MTH00135 250 LGGLPPLTGFMPKWLILQELTKQDLPLTATLAALSALLSLYFYLRLSYAMTLTISPNTLNGTTPWRLPST 319
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
 3-316 1.07e-46

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 161.55  E-value: 1.07e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350430929   3 LISTMSILLGTMVTITSNHWAMAWAGLEINTLSIIPMISKSHHPRAIEAATKYFLVQAAASTLVLFSSTVNAQHTGQWDI 82
Cdd:MTH00105   7 IIIYLTLFLGTMITMISSHWLLAWIGLEMNMLAIIPILMKKHNPRSTEAATKYFLTQATASMLLMMAIIINLMYSGQWTI 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350430929  83 TQLTYPPACVLLTTAIAIKLGLTPFHFWFPEVLQGSSL****************************************** 162
Cdd:MTH00105  87 TKLTNPTASTLMTIALAMKLGLAPFHFWVPEVTQGIPLSSGMILLTWQKLAPLSILYQISPSINPNLLLTLAILSILIGG 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350430929 163 *********************************************TSSIFLTLHTTNTLKLSTLMTSWTKTPMLNTTLML 242
Cdd:MTH00105 167 WGGLNQTQLRKILAYSSIAHMGWMTAILPYNPTLTLLNLLIYIIMTLTMFMLLMLNSSTTTLSLSHTWNKTPLMTSLILL 246

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 350430929 243 TLLSLSGLPPLTGFLPKWLIMQELIEQETTTTTTIISMLSLLGLFFYLRLAYCSTITLPPNPSSKIKQWFTKNP 316
Cdd:MTH00105 247 TLLSLGGLPPLTGFMPKWMIIQELTKNNNIILPTLMAITALLNLYFYMRLIYSTSLTMFPSTNNMKMKWQFENT 320
ND2 MTH00200
NADH dehydrogenase subunit 2; Provisional
 7-315 3.04e-42

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177246 [Multi-domain]  Cd Length: 347  Bit Score: 149.73  E-value: 3.04e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350430929   7 MSILLGTMVTITSNHWAMAWAGLEINTLSIIPMISKSHHPRAIEAATKYFLVQAAASTLVLFSSTVNAQHTGQWDITQLT 86
Cdd:MTH00200  11 LSLGLGTLLTFSSSHWFLIWLGLEINTLAIIPLLIKQHHPRKVEATTKYFIIQATASALLLFGGLLNAWTSGQWGISEML 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350430929  87 YPPACVLLTTAIAIKLGLTPFHFWFPEVLQGSSL********************************************** 166
Cdd:MTH00200  91 GPLSETLILLALALKLGLAPGHFWVPDVLQGLSLQTGLILSTWQKLAPFALLIQLAPALNSNILLLLGLLSVLVGGWGGL 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350430929 167 *****************************************TSSIFLTLHTTNTLKLSTLMTSWTKTPMLNTTLMLTLLS 246
Cdd:MTH00200 171 NQTQLRKILAYSSIAHLGWLLSGLVYSPNLALLYLLLYVIITLTVFLLLNLLNSTKINSLSSSKTKNPILSMLLGLTLLS 250

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 350430929 247 LSGLPPLTGFLPKWLIMQELIEQETTTTTTIISMLSLLGLFFYLRLAYCSTITLPPNPSSKIKQWFTKN 315
Cdd:MTH00200 251 LGGLPPLTGFFPKWLILQELSKQGLFIYATILLLGSLLSLFFYLRLSYLTLLTLSPNQINMMSSWRTKS 319
ND2 MTH00041
NADH dehydrogenase subunit 2; Validated
 8-120 9.07e-31

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 177116 [Multi-domain]  Cd Length: 349  Bit Score: 119.27  E-value: 9.07e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350430929   8 SILLGTMVTITSNHWAMAWAGLEINTLSIIPMISKSHHPRAIEAATKYFLVQAAASTLVLFSSTVNAQHTGQWDITQLTY 87
Cdd:MTH00041  12 SIILGTIIVISSNHWFLIWLGLELNTLSIIPILSSNFSPRSVEATIKYFLVQAFSAAILLNGALIQAWLSGSWSINGPLN 91

                         90       100       110
                 ....*....|....*....|....*....|...
gi 350430929  88 PPACVLLTTAIAIKLGLTPFHFWFPEVLQGSSL 120
Cdd:MTH00041  92 TLSSIIITLALALKLGLAPCHFWFPDVLQGLPF 124
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 1-119 4.17e-20

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 89.50  E-value: 4.17e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350430929   1 TKLISTMSILLGTMVTITSNHWAMAWAGLEINTLSIIPMISKSHHPRAIEAATKYFLVQAAASTLVLFSSTVNAQhtgqw 80
Cdd:MTH00160   6 SKLLFLSTLIMGTLISISSNSWFGAWMGLEINLLSFIPLISNKKNLMSSESSLKYFLIQALASIILLFSIILNML----- 80

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 350430929  81 dITQLTYPPACVLLTTAIAIKLGLTPFHFWFPEVLQGSS 119
Cdd:MTH00160  81 -NLMLFNNISSMLINSSLLLKLGAAPFHFWFPEVMEGLS 118
ND2 MTH00144
NADH dehydrogenase subunit 2; Provisional
 2-119 1.68e-16

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214432 [Multi-domain]  Cd Length: 328  Bit Score: 79.16  E-value: 1.68e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350430929   2 KLISTMSILLGTMVTITSNHWAMAWAGLEINTLSIIPMISKSHHPRAIEAATKYFLVQAAASTLVLFSSTVNAQHTGQWD 81
Cdd:MTH00144   6 NLLFLFLMVMGTLLSLSSSHWLGVWVGLEINLIGFLPLLVYKKKSSESESVVKYFIIQSLGSSLLIFGSLIMYNLSFSWF 85

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 350430929  82 ITqltyppacVLLTTAIAIKLGLTPFHFWFPEVLQGSS 119
Cdd:MTH00144  86 SM--------SLLLLGLCLKLGLFPFHFWVPSVMAGLS 115
ND2 MTH00011
NADH dehydrogenase subunit 2; Validated
 8-306 4.48e-14

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 164587 [Multi-domain]  Cd Length: 330  Bit Score: 72.12  E-value: 4.48e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350430929   8 SILLGTMVTITSNHWAMAWAGLEINTLSIIPMISKSHHPRAIEAATKYFLVQAAASTLVLFSSTVnaqhtgQWDITQLTY 87
Cdd:MTH00011  14 TMTLGTLMALSSNNWLFLWMGMELNLLSFVPLMTSSKMNQESEAAVKYFLAQALGSGLLLLGMTM------MWSFPSLLK 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350430929  88 PPACVLLTTAIAIKLGLTPFHFWFPEVLQGSSL*********************************************** 167
Cdd:MTH00011  88 NITALMLLVSLMLKLGMAPCHFWFPSVMSSISWTLCLILSTWQKIAPLSILFFFTSHNILPMMTSMAAMSALAGGLGGMN 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350430929 168 ****************************************TSSIFLTLHTTNTLKLSTLMTSWTKTPMLNTTLMLTLLSL 247
Cdd:MTH00011 168 QTQLRPLLAYSSIGHMGWMTMISVFSPSMAILYFMTYIIITTPLMLLFAYLNAFSTKFNSKISSMSQTTSMSLFIMLLSL 247

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 350430929 248 SGLPPLTGFLPKWLIMQELIEQETTTTTTIISMLSLLGLFFYLRLAYcSTITLPPNPSS 306
Cdd:MTH00011 248 GGLPPFTGFMPKLMAIETLTSNSMILILLVLIVGSLMNLFYYLNLIF-NFMYLSPTFSS 305
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 6-119 1.11e-12

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 68.60  E-value: 1.11e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350430929   6 TMSILLGTMVTITSNHWAMAWAGLEINTLSIIPMIS-KSHHPRAIEAATKYFLVQAAASTLVLF--------SSTVN--- 73
Cdd:COG1007  108 LLFATLGMMLMASANDLLTLFLGLELLSLSLYVLVAfRRDDRRSSEAALKYFLLGALSSGFLLYgisllygaTGSLNlag 187

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 350430929  74 -AQHTGQWDITQLTYPPACVLLTTAIAIKLGLTPFHFWFPEVLQGSS 119
Cdd:COG1007  188 iAAALAAGGANSPLLLLGLVLVLAGLAFKLSAVPFHMWTPDVYEGAP 234
ND2 MTH00197
NADH dehydrogenase subunit 2; Provisional
 8-116 7.95e-11

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177244 [Multi-domain]  Cd Length: 323  Bit Score: 62.38  E-value: 7.95e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350430929   8 SILLGTMVTITSNHWAMAWAGLEINTLSIIPMISKSHHPRAIEAATKYFLVQAAASTLVLFSSTVNAQHTgqwditqLTY 87
Cdd:MTH00197   6 IIFGGVLFSLSSSNWFLVWIGMELNLIGFIPLLSQNKSITENEGAMKYFLFQEFGSALLLMGGSLSFSNL-------YLS 78

                         90       100
                 ....*....|....*....|....*....
gi 350430929  88 PPACVLLTTAIAIKLGLTPFHFWFPEVLQ 116
Cdd:MTH00197  79 LLSVVLVILGLLLKLGAFPFHFWVPSVME 107
PRK05777 PRK05777
NADH-quinone oxidoreductase subunit NuoN;
10-118 9.11e-11

NADH-quinone oxidoreductase subunit NuoN;


Pssm-ID: 235603 [Multi-domain]  Cd Length: 476  Bit Score: 62.53  E-value: 9.11e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350430929  10 LLGTMVTITSNHWAMAWAGLEINTLSIIPMIS-KSHHPRAIEAATKYFLVQAAASTLVLF--------SSTVN----AQH 76
Cdd:PRK05777 113 LLGMMVMVSANDLLTLFLGLELLSLPLYALAAlRRDRRRSLEAAIKYFVLGALASGFLLYgmsllygaTGSLSfagiAKA 192

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 350430929  77 TGQWDITQLTYPPACVLLTTAIAIKLGLTPFHFWFPEVLQGS 118
Cdd:PRK05777 193 LADGSGNSLLLLFGLVFLLVGLAFKLSAVPFHMWTPDVYEGA 234
ND2 MTH00196
NADH dehydrogenase subunit 2; Provisional
 9-118 1.61e-07

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214453 [Multi-domain]  Cd Length: 365  Bit Score: 52.34  E-value: 1.61e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350430929   9 ILLGTMVTITSNHWAMAWAGLEINTLSIIPMI-SKSHHPRAIEAATKYFLVQAAASTLVLFSSTVNAQHTGQWDI----- 82
Cdd:MTH00196   2 VALGILCLISSSNWLSVYLAIELQTLSLFILIaQNRGSGYSAEAGLKYFVLGALSSGLFLFGCALLCGTTGGLHLsyinl 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 350430929  83 --------TQLTYPPACVLLTTAIAIKLGLTPFHFWFPEVLQGS 118
Cdd:MTH00196  82 vlnsgqsfSSVSVPIGYLLIIVALLFKLSVAPFHMWAPDVYEGA 125
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 9-118 8.43e-07

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 50.33  E-value: 8.43e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350430929    9 ILLGTMVTITSNHWAMAWAGLEINTLSI-IPMISKSHHPRAIEAATKYFLVQAAASTLVLFSSTV--------------N 73
Cdd:TIGR01770 111 ALLGIFLLVSSNDLLSIYLGLELQSLCFyVLAGLKRKSRFSTEAGLKYFILGAFSSGLLLFGISLiygftgslnfedllL 190

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 350430929   74 AQHTGQWDITQLTYppACVLLTTAIAIKLGLTPFHFWFPEVLQGS 118
Cdd:TIGR01770 191 FLSNGMLNISLLLL--GIVLILVGLLFKLSAVPFHMWVPDVYEGA 233
HyfB COG0651
Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy ...
 10-112 1.59e-06

Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 440416 [Multi-domain]  Cd Length: 430  Bit Score: 49.38  E-value: 1.59e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350430929  10 LLGTMVTITSNHWAMAWAGLEINTLSIIPMISKSHHPRAIEAATKYFLVQAAASTLVLFSSTVNAQHTGQWDITQL---- 85
Cdd:COG0651  117 LAGMNGAFLTGDLFNLFVFFEVMLLASYGLVALGGTKEALRAGLKYLILNLVGSALFLLGVGLLYGATGTLNMADLaarl 196

                         90       100       110
                 ....*....|....*....|....*....|...
gi 350430929  86 -TYPP-----ACVLLTTAIAIKLGLTPFHFWFP 112
Cdd:COG0651  197 aELDPglllaAFALLLVGFGIKAALFPLHFWLP 229
ND2 MTH00199
NADH dehydrogenase subunit 2; Provisional
 9-119 3.57e-06

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177245 [Multi-domain]  Cd Length: 460  Bit Score: 48.47  E-value: 3.57e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350430929   9 ILLGTMVTITSNHWAMAWAGLEINTLSIIPMIS-KSHHPRAIEAATKYFLVQAAASTLVLFSSTVNAQHTGQWDITQLTY 87
Cdd:MTH00199 106 VALGSLLLVSSINWLSIYLAIELQTLTLFILVAlKRDSAYSTEAGLKYFVLGAVSSGLFLFGCALLYGLTGETSIQGINS 185

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 350430929  88 PPAC----VLLTTAIAIKLGLTPFHFWFPEVLQGSS 119
Cdd:MTH00199 186 ILTGdvgkILITISLLFKLSAAPFHMWAPDVYEGAP 221
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 19-119 5.18e-06

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 47.31  E-value: 5.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350430929   19 SNHWAMAWAGLEINTLSIIPMI-SKSHHPRAIEAATKYFLVQAAASTLVLFSSTVNAQHTGQWDITQL-TYPPAC----- 91
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLLIgYWGKSPRSSEAGMKYFLLTLLGSSILLFGISLMYNYTGTLSFDELsKALTGGlnssg 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 350430929   92 -----VLLTTAIAIKLGLTPFHFWFPEVLQGSS 119
Cdd:pfam00361  81 llllfLLILVGFLFKSAQVPFHTWLPDAYEGAP 113
PRK06458 PRK06458
hydrogenase 4 subunit F; Validated
 8-112 1.97e-04

hydrogenase 4 subunit F; Validated


Pssm-ID: 235805 [Multi-domain]  Cd Length: 490  Bit Score: 42.99  E-value: 1.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350430929   8 SILLGTMV-TITSNHWAMAWAGLEINTLSIIPMISKSHHPRAIEAATKYFLVQAAASTLVLFSS---------------- 70
Cdd:PRK06458 115 QLFLFTMLlALTSNNLGLMWVAIEATTLSSALLVGIYRTRASLEAAWKYIIICSVGVAFALFGTilvyanaatvmgdgem 194

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 350430929  71 ----TVNAQHTGQWDITQLTYppACVLLTTAIAIKLGLTPFHFWFP 112
Cdd:PRK06458 195 ailwTELLKHASLLDPTLMKL--AFVFLLIGFGTKVGLFPMHAWLP 238
PRK02504 PRK02504
NAD(P)H-quinone oxidoreductase subunit N;
11-118 5.54e-04

NAD(P)H-quinone oxidoreductase subunit N;


Pssm-ID: 235044 [Multi-domain]  Cd Length: 513  Bit Score: 41.58  E-value: 5.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350430929  11 LGTMVTITSNHWAMAWAGLEinTLSIIPMISKSH---HPRAIEAATKYFLVQAAASTLVLFSST----VNAQHTGQWDIT 83
Cdd:PRK02504 121 LGGMFLSGATELVMIFISLE--TLSIASYLLTGYmkrDPRSNEAALKYLLIGAASSAIFLYGSSllygLSGGSTQLSAIA 198

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 350430929  84 Q-LTYPP------ACVLLTTAIAIKLGLTPFHFWFPEVLQGS 118
Cdd:PRK02504 199 LaLITSPslglalALVFVIAGIAFKISAVPFHQWTPDVYEGS 240
PRK08376 PRK08376
putative monovalent cation/H+ antiporter subunit D; Reviewed
 29-113 1.36e-03

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 236252 [Multi-domain]  Cd Length: 521  Bit Score: 40.47  E-value: 1.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350430929  29 LEINTLSIIPMIS-KSHHPRAIEAATKYFLVQAAASTLVLFSStvnAQHTGQWDITQLTYPP-------------ACVLL 94
Cdd:PRK08376 150 LEIMSIASYALVAfRNDTWEAIEAGIKYMFVGSLASSMVLLGI---ALLYGQYGTLNMAYLAvkmsenptvvakiALALF 226

                         90
                 ....*....|....*....
gi 350430929  95 TTAIAIKLGLTPFHFWFPE 113
Cdd:PRK08376 227 IAGLAMKSGAVPVHMWLPD 245
ndhB CHL00049
NADH dehydrogenase subunit 2
 47-118 2.67e-03

NADH dehydrogenase subunit 2


Pssm-ID: 176990 [Multi-domain]  Cd Length: 494  Bit Score: 39.60  E-value: 2.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350430929  47 RAIEAATKYFLVQAAASTLVL--FSST--VNAQHTGQWDI------TQLTYPPAC----VLLTTAIAIKLGLTPFHFWFP 112
Cdd:CHL00049 159 RSNEATMKYLLMGGASSSILVygFSWLygLSGGEIELQEIvnglinTQMYNSPGIsialIFITVGIGFKLSLAPFHQWTP 238


                 ....*.
gi 350430929 113 EVLQGS 118
Cdd:CHL00049 239 DVYEGS 244
PRK08375 PRK08375
putative monovalent cation/H+ antiporter subunit D; Reviewed
 29-112 5.46e-03

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 236251 [Multi-domain]  Cd Length: 487  Bit Score: 38.32  E-value: 5.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350430929  29 LEINTLSIIPMISKSHHPRAIEAATKYFLVQAAASTLVLFSSTVNAQHTGQWDITQLT--YPPACVLLT------TAIAI 100
Cdd:PRK08375 135 LEIMSLSSYALVAMGGDRRALAAARKYLIVGLIGSTFLLIGVGLLYGVTGTLNMADLAgaLAENPTVVTafgfvlLALAL 214

                         90
                 ....*....|..
gi 350430929 101 KLGLTPFHFWFP 112
Cdd:PRK08375 215 KAAVFPLHTWLP 226
NuoM COG1008
NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH: ...
 34-112 7.72e-03

NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 4 (chain M) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440632 [Multi-domain]  Cd Length: 488  Bit Score: 38.14  E-value: 7.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350430929  34 LSIIPM---ISKSHHPRAIEAATKYFLVQAAASTLVLFSSTVNAQHTGQW-----DITQLTYPPA-----CVLLTTAIAI 100
Cdd:COG1008  142 LMLIPMyflIGIWGGERRIYAAIKFFLYTLAGSLLMLVAILALYFLAGALtfdiaELAAAPLPLTaqlllFLAFFIAFAV 221

                         90
                 ....*....|..
gi 350430929 101 KLGLTPFHFWFP 112
Cdd:COG1008  222 KVPMFPFHTWLP 233
PRK08168 PRK08168
NADH-quinone oxidoreductase subunit L;
6-116 9.92e-03

NADH-quinone oxidoreductase subunit L;


Pssm-ID: 236171 [Multi-domain]  Cd Length: 516  Bit Score: 37.76  E-value: 9.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350430929   6 TMSILLGTMVTITSNHWAM---AWAGLEI---NTLSIIPmisksHHPRAIEAATKYFLVQAAASTLVLFSSTVNAQHTGQ 79
Cdd:PRK08168 106 LAGVLAAVHLLVLSDHLLVliaAWAAISLalhRLLCFYP-----DRPFARLAAHKKFIADRLAELLLLAAAALAYLEVGS 180

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 350430929  80 WDITQL-----TYPP------ACVLLTTAIAIKLGLTPFHFWFPEVLQ 116
Cdd:PRK08168 181 LSLSALwahlaAQGAspslqaAALLLVLAVILKTAQLPVHGWLIQVME 228
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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