CI with mf Lon degradtion tag [Cloning vector DH4-27]
LexA family protein( domain architecture ID 11449429)
LexA family protein may function as a transcriptional regulator involved in the repression of one or more genes involved in the response to DNA damage (SOS response), including recA and lexA and/or may contain a S24 peptidase domain such as in the translesion error-prone DNA polymerase V autoproteolytic subunit
List of domain hits
Name | Accession | Description | Interval | E-value | ||||
LexA | COG1974 | SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, ... |
6-231 | 1.36e-42 | ||||
SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, Signal transduction mechanisms]; : Pssm-ID: 441577 [Multi-domain] Cd Length: 199 Bit Score: 143.90 E-value: 1.36e-42
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Name | Accession | Description | Interval | E-value | ||||
LexA | COG1974 | SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, ... |
6-231 | 1.36e-42 | ||||
SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, Signal transduction mechanisms]; Pssm-ID: 441577 [Multi-domain] Cd Length: 199 Bit Score: 143.90 E-value: 1.36e-42
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Peptidase_S24 | pfam00717 | Peptidase S24-like; |
105-227 | 4.58e-35 | ||||
Peptidase S24-like; Pssm-ID: 425835 Cd Length: 116 Bit Score: 121.93 E-value: 4.58e-35
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S24_LexA-like | cd06529 | Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of ... |
142-227 | 7.86e-22 | ||||
Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the repressor of genes in the cellular SOS response to DNA damage; MucA and the related UmuD proteins, which are lesion-bypass DNA polymerases, induced in response to mitogenic DNA damage; RulA, a component of the rulAB locus that confers resistance to UV, and RuvA, which is a component of the RuvABC resolvasome that catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. The LexA-like proteins contain two-domains: an N-terminal DNA binding domain and a C-terminal domain (CTD) that provides LexA dimerization as well as cleavage activity. They undergo autolysis, cleaving at an Ala-Gly or a Cys-Gly bond, separating the DNA-binding domain from the rest of the protein. In the presence of single-stranded DNA, the LexA, UmuD and MucA proteins interact with RecA, activating self cleavage, thus either derepressing transcription in the case of LexA or activating the lesion-bypass polymerase in the case of UmuD and MucA. The LexA proteins are serine proteases that carry out catalysis using a serine/lysine dyad instead of the prototypical serine/histidine/aspartic acid triad found in most serine proteases. LexA sequence homologs are found in almost all of the bacterial genomes sequenced to date, covering a large number of phyla, suggesting both, an ancient origin and a widespread distribution of lexA and the SOS response. Pssm-ID: 119397 [Multi-domain] Cd Length: 81 Bit Score: 86.46 E-value: 7.86e-22
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HTH_XRE | smart00530 | Helix-turn-helix XRE-family like proteins; |
18-77 | 4.82e-09 | ||||
Helix-turn-helix XRE-family like proteins; Pssm-ID: 197775 [Multi-domain] Cd Length: 56 Bit Score: 51.36 E-value: 4.82e-09
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PRK10276 | PRK10276 | translesion error-prone DNA polymerase V autoproteolytic subunit; |
98-227 | 8.06e-06 | ||||
translesion error-prone DNA polymerase V autoproteolytic subunit; Pssm-ID: 182350 Cd Length: 139 Bit Score: 44.40 E-value: 8.06e-06
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Name | Accession | Description | Interval | E-value | ||||
LexA | COG1974 | SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, ... |
6-231 | 1.36e-42 | ||||
SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, Signal transduction mechanisms]; Pssm-ID: 441577 [Multi-domain] Cd Length: 199 Bit Score: 143.90 E-value: 1.36e-42
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Peptidase_S24 | pfam00717 | Peptidase S24-like; |
105-227 | 4.58e-35 | ||||
Peptidase S24-like; Pssm-ID: 425835 Cd Length: 116 Bit Score: 121.93 E-value: 4.58e-35
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S24_LexA-like | cd06529 | Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of ... |
142-227 | 7.86e-22 | ||||
Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the repressor of genes in the cellular SOS response to DNA damage; MucA and the related UmuD proteins, which are lesion-bypass DNA polymerases, induced in response to mitogenic DNA damage; RulA, a component of the rulAB locus that confers resistance to UV, and RuvA, which is a component of the RuvABC resolvasome that catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. The LexA-like proteins contain two-domains: an N-terminal DNA binding domain and a C-terminal domain (CTD) that provides LexA dimerization as well as cleavage activity. They undergo autolysis, cleaving at an Ala-Gly or a Cys-Gly bond, separating the DNA-binding domain from the rest of the protein. In the presence of single-stranded DNA, the LexA, UmuD and MucA proteins interact with RecA, activating self cleavage, thus either derepressing transcription in the case of LexA or activating the lesion-bypass polymerase in the case of UmuD and MucA. The LexA proteins are serine proteases that carry out catalysis using a serine/lysine dyad instead of the prototypical serine/histidine/aspartic acid triad found in most serine proteases. LexA sequence homologs are found in almost all of the bacterial genomes sequenced to date, covering a large number of phyla, suggesting both, an ancient origin and a widespread distribution of lexA and the SOS response. Pssm-ID: 119397 [Multi-domain] Cd Length: 81 Bit Score: 86.46 E-value: 7.86e-22
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Peptidase_S24_S26 | cd06462 | The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal ... |
142-226 | 1.18e-16 | ||||
The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the repressor of genes in the cellular SOS response to DNA damage; MucA and the related UmuD proteins, which are lesion-bypass DNA polymerases, induced in response to mitogenic DNA damage; RulA, a component of the rulAB locus that confers resistance to UV, and RuvA, which is a component of the RuvABC resolvasome that catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. The S26 type I signal peptidase (SPase) family also includes mitochondrial inner membrane protease (IMP)-like members. SPases are essential membrane-bound proteases which function to cleave away the amino-terminal signal peptide from the translocated pre-protein, thus playing a crucial role in the transport of proteins across membranes in all living organisms. All members in this superfamily are unique serine proteases that carry out catalysis using a serine/lysine dyad instead of the prototypical serine/histidine/aspartic acid triad found in most serine proteases. Pssm-ID: 119396 [Multi-domain] Cd Length: 84 Bit Score: 72.68 E-value: 1.18e-16
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COG2932 | COG2932 | Phage repressor protein C, contains Cro/C1-type HTH and peptisase s24 domains [Mobilome: ... |
138-227 | 7.56e-14 | ||||
Phage repressor protein C, contains Cro/C1-type HTH and peptisase s24 domains [Mobilome: prophages, transposons]; Pssm-ID: 442176 Cd Length: 121 Bit Score: 66.14 E-value: 7.56e-14
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HTH_XRE | cd00093 | Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ... |
16-77 | 2.81e-09 | ||||
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators. Pssm-ID: 238045 [Multi-domain] Cd Length: 58 Bit Score: 52.17 E-value: 2.81e-09
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HTH_3 | pfam01381 | Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ... |
24-77 | 3.30e-09 | ||||
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family. Pssm-ID: 460181 [Multi-domain] Cd Length: 55 Bit Score: 51.77 E-value: 3.30e-09
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HTH_XRE | smart00530 | Helix-turn-helix XRE-family like proteins; |
18-77 | 4.82e-09 | ||||
Helix-turn-helix XRE-family like proteins; Pssm-ID: 197775 [Multi-domain] Cd Length: 56 Bit Score: 51.36 E-value: 4.82e-09
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HipB | COG1396 | Transcriptional regulator, contains XRE-family HTH domain [Transcription]; |
1-77 | 3.87e-07 | ||||
Transcriptional regulator, contains XRE-family HTH domain [Transcription]; Pssm-ID: 441006 [Multi-domain] Cd Length: 83 Bit Score: 46.91 E-value: 3.87e-07
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XRE | COG1476 | DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription]; |
16-77 | 4.69e-06 | ||||
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription]; Pssm-ID: 441085 [Multi-domain] Cd Length: 68 Bit Score: 43.30 E-value: 4.69e-06
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PRK10276 | PRK10276 | translesion error-prone DNA polymerase V autoproteolytic subunit; |
98-227 | 8.06e-06 | ||||
translesion error-prone DNA polymerase V autoproteolytic subunit; Pssm-ID: 182350 Cd Length: 139 Bit Score: 44.40 E-value: 8.06e-06
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aMBF1 | COG1813 | Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and ... |
16-76 | 1.21e-05 | ||||
Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains [Translation, ribosomal structure and biogenesis]; Pssm-ID: 441418 [Multi-domain] Cd Length: 70 Bit Score: 42.23 E-value: 1.21e-05
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Blast search parameters | ||||
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