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Conserved domains on  [gi|403390015|gb|AFR42999|]
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reelin, partial [Trachemys grayi emolli]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Reelin_subrepeat_like super family cl15240
Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein ...
 1-43 7.78e-27

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.


The actual alignment was detected with superfamily member cd10052:

Pssm-ID: 197448 [Multi-domain]  Cd Length: 161  Bit Score: 93.71  E-value: 7.78e-27
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 403390015   1 SLYFNGCQIRQAITKPLDLTRASKIMFVLQIGSISQTESCNTN 43
Cdd:cd10052   41 SLYFNGCGIRQAVTVELDLTRASKIMFVLQIGSRSQTDSCNIN 83
 
Name Accession Description Interval E-value
Reelin_repeat_8_subrepeat_2 cd10052
C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an ...
 1-43 7.78e-27

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197360 [Multi-domain]  Cd Length: 161  Bit Score: 93.71  E-value: 7.78e-27
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 403390015   1 SLYFNGCQIRQAITKPLDLTRASKIMFVLQIGSISQTESCNTN 43
Cdd:cd10052   41 SLYFNGCGIRQAVTVELDLTRASKIMFVLQIGSRSQTDSCNIN 83
 
Name Accession Description Interval E-value
Reelin_repeat_8_subrepeat_2 cd10052
C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an ...
 1-43 7.78e-27

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197360 [Multi-domain]  Cd Length: 161  Bit Score: 93.71  E-value: 7.78e-27
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 403390015   1 SLYFNGCQIRQAITKPLDLTRASKIMFVLQIGSISQTESCNTN 43
Cdd:cd10052   41 SLYFNGCGIRQAVTVELDLTRASKIMFVLQIGSRSQTDSCNIN 83
Reelin_subrepeat_2 cd08526
C-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an ...
 1-41 8.23e-18

C-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197343 [Multi-domain]  Cd Length: 152  Bit Score: 70.33  E-value: 8.23e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 403390015   1 SLYFNGCQIRQAITKPLDLTRASKIMFVLQIGSISQTESCN 41
Cdd:cd08526   36 ALYFNGPGLRQLVTVDLDLTNARFVQFYLRIGSKSQTSTCN 76
Reelin_repeat_7_subrepeat_2 cd10051
C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an ...
 1-42 2.63e-07

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197359  Cd Length: 162  Bit Score: 43.23  E-value: 2.63e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 403390015   1 SLYFNGCQIRQAITKPLDLTRASKIMFVLQIGSISQTESCNT 42
Cdd:cd10051   38 ALYFGGSGARQAVTQDLDLRGAKFVQYWARIGSENNMTLCLR 79
Reelin_repeat_3_subrepeat_2 cd10047
C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an ...
 1-41 3.28e-07

C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197355  Cd Length: 151  Bit Score: 42.88  E-value: 3.28e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 403390015   1 SLYFNGCQIRQAITKPLDLTRASKIMFVLQIGSISQTESCN 41
Cdd:cd10047   36 SLYFNGPGKREARTVPLDTTNIRLVQFYIQIGSKLNGETCL 76
Reelin_repeat_1_subrepeat_2 cd10045
C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an ...
 1-40 2.19e-05

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197353 [Multi-domain]  Cd Length: 155  Bit Score: 38.24  E-value: 2.19e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 403390015   1 SLYFNGCQIRQAITKPLDLTRASKIMFVLQIGSISQTESC 40
Cdd:cd10045   39 ALVFNGDGRRQLITAPLDSTQSRYLQFTLRLGSKSVLGTC 78
Reelin_repeat_2_subrepeat_2 cd10046
C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an ...
 1-41 3.75e-03

C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197354 [Multi-domain]  Cd Length: 156  Bit Score: 32.13  E-value: 3.75e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 403390015   1 SLYFNGCQIRQAITKPLDLTRASKIMFVLQIGsiSQTESCN 41
Cdd:cd10046   42 SLYFNKDGLRQLVSWDLDTTWVDFIQFYIQIG--GGSASCN 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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