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Conserved domains on  [gi|405133373|gb|AFS17494|]
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dynein axonemal heavy chain 3, partial [Anser albifrons]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MT super family cl37598
Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA ...
 12-190 1.26e-30

Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This family is the region between D4 and D5 and is the two predicted alpha-helical coiled coil segments that form the stalk supporting the ATP-sensitive microtubule binding component.


The actual alignment was detected with superfamily member pfam12777:

Pssm-ID: 463699 [Multi-domain]  Cd Length: 344  Bit Score: 115.94  E-value: 1.26e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405133373   12 FLESLKAYDKDNIPPAIMKRIRErFINHPDFQPAVIKNVSSACEGLCKW----VRAMEVY-DrvakvVAPKRERLRTAEE 86
Cdd:pfam12777 155 FLDSLIKFDKEHIHEACLKAFKP-YLGDPEFDPEFIASKSTAAAGLCSWciniVRFYEVFcD-----VAPKRQALEEANA 228

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405133373   87 LLDVQMQKLKTKQAELKEVVDRLQALNDDFENMNDRKRELENNIELCSKKLVRAEQLISGLGGEKDRWTEAARLLRIRYI 166
Cdd:pfam12777 229 DLAAAQEKLAAIKAKIAELNANLAKLTAAFEKATADKIKCQQEADATARTILLANRLVGGLASENIRWADAVENFKQQER 308

                         170       180
                  ....*....|....*....|....
gi 405133373  167 DLTGDVLLSSGTVAYLGAFTVDYR 190
Cdd:pfam12777 309 TLCGDILLISAFISYLGFFTKKYR 332
 
Name Accession Description Interval E-value
MT pfam12777
Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA ...
 12-190 1.26e-30

Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This family is the region between D4 and D5 and is the two predicted alpha-helical coiled coil segments that form the stalk supporting the ATP-sensitive microtubule binding component.


Pssm-ID: 463699 [Multi-domain]  Cd Length: 344  Bit Score: 115.94  E-value: 1.26e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405133373   12 FLESLKAYDKDNIPPAIMKRIRErFINHPDFQPAVIKNVSSACEGLCKW----VRAMEVY-DrvakvVAPKRERLRTAEE 86
Cdd:pfam12777 155 FLDSLIKFDKEHIHEACLKAFKP-YLGDPEFDPEFIASKSTAAAGLCSWciniVRFYEVFcD-----VAPKRQALEEANA 228

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405133373   87 LLDVQMQKLKTKQAELKEVVDRLQALNDDFENMNDRKRELENNIELCSKKLVRAEQLISGLGGEKDRWTEAARLLRIRYI 166
Cdd:pfam12777 229 DLAAAQEKLAAIKAKIAELNANLAKLTAAFEKATADKIKCQQEADATARTILLANRLVGGLASENIRWADAVENFKQQER 308

                         170       180
                  ....*....|....*....|....
gi 405133373  167 DLTGDVLLSSGTVAYLGAFTVDYR 190
Cdd:pfam12777 309 TLCGDILLISAFISYLGFFTKKYR 332
DYN1 COG5245
Dynein, heavy chain [Cytoskeleton];
26-183 4.11e-06

Dynein, heavy chain [Cytoskeleton];


Pssm-ID: 227570 [Multi-domain]  Cd Length: 3164  Bit Score: 47.29  E-value: 4.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405133373   26 PAIMKRIRERFINHPDFQPAVIKNVSSACEGLCKWVRAMEVYDRVAKVVAPkrerLRTAEELLDVQMQKLKTKQAELKEV 105
Cdd:COG5245  2258 LEARRFREARECSDPSFTGSILNRASKACGPLKRWLVRECNRSKVLEVKIP----LREEEKRIDGEAFLVEDRLTLGKGL 2333

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405133373  106 VDRLQA----LNDDFENMNDRKRELENNIELCSKKLVRAEQLISGLGGEKDRWTEAARLLRIRYIDLTGDVLLSSGTVAY 181
Cdd:COG5245  2334 SSDLMTfklrRRSYYSLDILRVHGKIADMDTVHKDVLRSIFVSEILINEDSEWGGVFSEVPKLMVELDGDGHPSSCLHPY 2413


                  ..
gi 405133373  182 LG 183
Cdd:COG5245  2414 IG 2415
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 77-162 3.24e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 38.50  E-value: 3.24e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405133373    77 KRERLRTAEELLDVQmQKLKTKQAELKEVVDRLQALNDDFENMNDRKRELE--------------NNIELCSKKLVRAEQ 142
Cdd:TIGR02168  329 ESKLDELAEELAELE-EKLEELKEELESLEAELEELEAELEELESRLEELEeqletlrskvaqleLQIASLNNEIERLEA 407

                           90       100
                   ....*....|....*....|
gi 405133373   143 LISGLGGEKDRWTEAARLLR 162
Cdd:TIGR02168  408 RLERLEDRRERLQQEIEELL 427
 
Name Accession Description Interval E-value
MT pfam12777
Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA ...
 12-190 1.26e-30

Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This family is the region between D4 and D5 and is the two predicted alpha-helical coiled coil segments that form the stalk supporting the ATP-sensitive microtubule binding component.


Pssm-ID: 463699 [Multi-domain]  Cd Length: 344  Bit Score: 115.94  E-value: 1.26e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405133373   12 FLESLKAYDKDNIPPAIMKRIRErFINHPDFQPAVIKNVSSACEGLCKW----VRAMEVY-DrvakvVAPKRERLRTAEE 86
Cdd:pfam12777 155 FLDSLIKFDKEHIHEACLKAFKP-YLGDPEFDPEFIASKSTAAAGLCSWciniVRFYEVFcD-----VAPKRQALEEANA 228

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405133373   87 LLDVQMQKLKTKQAELKEVVDRLQALNDDFENMNDRKRELENNIELCSKKLVRAEQLISGLGGEKDRWTEAARLLRIRYI 166
Cdd:pfam12777 229 DLAAAQEKLAAIKAKIAELNANLAKLTAAFEKATADKIKCQQEADATARTILLANRLVGGLASENIRWADAVENFKQQER 308

                         170       180
                  ....*....|....*....|....
gi 405133373  167 DLTGDVLLSSGTVAYLGAFTVDYR 190
Cdd:pfam12777 309 TLCGDILLISAFISYLGFFTKKYR 332
DYN1 COG5245
Dynein, heavy chain [Cytoskeleton];
26-183 4.11e-06

Dynein, heavy chain [Cytoskeleton];


Pssm-ID: 227570 [Multi-domain]  Cd Length: 3164  Bit Score: 47.29  E-value: 4.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405133373   26 PAIMKRIRERFINHPDFQPAVIKNVSSACEGLCKWVRAMEVYDRVAKVVAPkrerLRTAEELLDVQMQKLKTKQAELKEV 105
Cdd:COG5245  2258 LEARRFREARECSDPSFTGSILNRASKACGPLKRWLVRECNRSKVLEVKIP----LREEEKRIDGEAFLVEDRLTLGKGL 2333

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405133373  106 VDRLQA----LNDDFENMNDRKRELENNIELCSKKLVRAEQLISGLGGEKDRWTEAARLLRIRYIDLTGDVLLSSGTVAY 181
Cdd:COG5245  2334 SSDLMTfklrRRSYYSLDILRVHGKIADMDTVHKDVLRSIFVSEILINEDSEWGGVFSEVPKLMVELDGDGHPSSCLHPY 2413


                  ..
gi 405133373  182 LG 183
Cdd:COG5245  2414 IG 2415
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 77-162 3.24e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 38.50  E-value: 3.24e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405133373    77 KRERLRTAEELLDVQmQKLKTKQAELKEVVDRLQALNDDFENMNDRKRELE--------------NNIELCSKKLVRAEQ 142
Cdd:TIGR02168  329 ESKLDELAEELAELE-EKLEELKEELESLEAELEELEAELEELESRLEELEeqletlrskvaqleLQIASLNNEIERLEA 407

                           90       100
                   ....*....|....*....|
gi 405133373   143 LISGLGGEKDRWTEAARLLR 162
Cdd:TIGR02168  408 RLERLEDRRERLQQEIEELL 427
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 77-169 5.16e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 37.61  E-value: 5.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405133373  77 KRERLRTAEELLDVQMQKLKTKQAELKEVVDRLQALNDDFENMNDRKRELENNIELCSKKLVRAEQLISGLGGEKDRWTE 156
Cdd:COG1196  244 LEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEE 323

                         90
                 ....*....|...
gi 405133373 157 AARLLRIRYIDLT 169
Cdd:COG1196  324 ELAELEEELEELE 336
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 80-152 8.36e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 36.44  E-value: 8.36e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 405133373  80 RLRTAEELLDVQMQKLKTKQAELKEVVDRLQALNDDFENMNDRKRELENNIELCSKKLVRAEQLISGLGGEKD 152
Cdd:COG1579   18 ELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVRNNKE 90
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
78-164 8.52e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 37.20  E-value: 8.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405133373   78 RERLRTAEELLDVQMQKLKTKQA-----ELKEVVDRLQALNDDFENMNDRKRELENNIELCSKKLVRAEQLISGLGGEKD 152
Cdd:COG4913   644 QERREALQRLAEYSWDEIDVASAereiaELEAELERLDASSDDLAALEEQLEELEAELEELEEELDELKGEIGRLEKELE 723

                          90
                  ....*....|..
gi 405133373  153 RWTEAARLLRIR 164
Cdd:COG4913   724 QAEEELDELQDR 735
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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