|
Name |
Accession |
Description |
Interval |
E-value |
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
136-312 |
5.44e-21 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 93.84 E-value: 5.44e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351402 136 QYLNFSHNALTDeLFQNCGTLVELKLLILQKNKFESLPKVsfmTSRMKSLKYLDMSNNLLRHDGADVrcQWAESLTELDL 215
Cdd:COG4886 116 ESLDLSGNQLTD-LPEELANLTNLKELDLSNNQLTDLPEP---LGNLTNLKSLDLSNNQLTDLPEEL--GNLTNLKELDL 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351402 216 SSNQLAD--AVFACLPvNVKKLSLQNNQISNVPRGMVELKSLEELNLASNRLADLPGCSGFTSLQFLNVEMNSI--LTPS 291
Cdd:COG4886 190 SNNQITDlpEPLGNLT-NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLtdLPPL 268
|
170 180
....*....|....*....|.
gi 514351402 292 ADFfqscPRVRELQAGHNPFK 312
Cdd:COG4886 269 ANL----TNLKTLDLSNNQLT 285
|
|
| LRRCT |
smart00082 |
Leucine rich repeat C-terminal domain; |
309-361 |
1.56e-06 |
|
Leucine rich repeat C-terminal domain;
Pssm-ID: 214507 [Multi-domain] Cd Length: 51 Bit Score: 44.73 E-value: 1.56e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 514351402 309 NPFKCSCELQAFVGLERQSggKLFGWPAAYVCEYPEGLRGtELKDFHLSQLAC 361
Cdd:smart00082 1 NPFICDCELRWLLRWLQAN--EHLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
158-220 |
2.98e-06 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 44.05 E-value: 2.98e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 514351402 158 ELKLLILQKNKFESLPKVSFmtSRMKSLKYLDMSNNLLRHDGADVrCQWAESLTELDLSSNQL 220
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAF--KGLSNLKVLDLSNNLLTTLSPGA-FSGLPSLRYLDLSGNRL 61
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
159-311 |
1.11e-05 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 45.93 E-value: 1.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351402 159 LKLLILQKNKFESLPKVSFMTSrmksLKYLDMSNNLLRHdgadvrcqwAESLTELdlssnqladavfaclpVNVKKLSLQ 238
Cdd:cd21340 26 LKVLYLYDNKITKIENLEFLTN----LTHLYLQNNQIEK---------IENLENL----------------VNLKKLYLG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351402 239 NNQISNV----------------------------PRGMVEL-KSLEELNLASNRLADLPGCSGFTSLQFLNVEMNSI-- 287
Cdd:cd21340 77 GNRISVVeglenltnleelhienqrlppgekltfdPRSLAALsNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQIsd 156
|
170 180
....*....|....*....|....
gi 514351402 288 LTPSADFFQSCPRVRELQAGHNPF 311
Cdd:cd21340 157 LEELLDLLSSWPSLRELDLTGNPV 180
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
159-311 |
2.77e-05 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 46.23 E-value: 2.77e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351402 159 LKLLILQKNKFESLPKvsfmtSRMKSLKYLDMSNNLLRHDGADVrcqwAESLTELDLSSNQLA----------------D 222
Cdd:PRK15370 264 LQSLDLFHNKISCLPE-----NLPEELRYLSVYDNSIRTLPAHL----PSGITHLNVQSNSLTalpetlppglktleagE 334
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351402 223 AVFACLPVNV----KKLSLQNNQISNVPRGMVelKSLEELNLASNRLADLPGcSGFTSLQFLNVEMNSILT-PSA--DFF 295
Cdd:PRK15370 335 NALTSLPASLppelQVLDVSKNQITVLPETLP--PTITTLDVSRNALTNLPE-NLPAALQIMQASRNNLVRlPESlpHFR 411
|
170
....*....|....*.
gi 514351402 296 QSCPRVRELQAGHNPF 311
Cdd:PRK15370 412 GEGPQPTRIIVEYNPF 427
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
136-312 |
5.44e-21 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 93.84 E-value: 5.44e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351402 136 QYLNFSHNALTDeLFQNCGTLVELKLLILQKNKFESLPKVsfmTSRMKSLKYLDMSNNLLRHDGADVrcQWAESLTELDL 215
Cdd:COG4886 116 ESLDLSGNQLTD-LPEELANLTNLKELDLSNNQLTDLPEP---LGNLTNLKSLDLSNNQLTDLPEEL--GNLTNLKELDL 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351402 216 SSNQLAD--AVFACLPvNVKKLSLQNNQISNVPRGMVELKSLEELNLASNRLADLPGCSGFTSLQFLNVEMNSI--LTPS 291
Cdd:COG4886 190 SNNQITDlpEPLGNLT-NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLtdLPPL 268
|
170 180
....*....|....*....|.
gi 514351402 292 ADFfqscPRVRELQAGHNPFK 312
Cdd:COG4886 269 ANL----TNLKTLDLSNNQLT 285
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
154-312 |
1.19e-16 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 80.75 E-value: 1.19e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351402 154 GTLVELKLLILQKNKFESLPKVsfmTSRMKSLKYLDMSNNLLRHDGADVRCqwAESLTELDLSSNQLAD--AVFACLPvN 231
Cdd:COG4886 110 SNLTNLESLDLSGNQLTDLPEE---LANLTNLKELDLSNNQLTDLPEPLGN--LTNLKSLDLSNNQLTDlpEELGNLT-N 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351402 232 VKKLSLQNNQISNVPRGMVELKSLEELNLASNRLADLPGC-SGFTSLQFLNVEMNSIltPSADFFQSCPRVRELQAGHNP 310
Cdd:COG4886 184 LKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPlANLTNLETLDLSNNQL--TDLPELGNLTNLEELDLSNNQ 261
|
..
gi 514351402 311 FK 312
Cdd:COG4886 262 LT 263
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
208-312 |
5.77e-09 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 57.25 E-value: 5.77e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351402 208 ESLTELDLSSNQLadavFACLPvNVKKLSLQNNQISNVPRGMVELKSLEELNLASNRLADLP-GCSGFTSLQFLNVEMNS 286
Cdd:COG4886 96 TNLTELDLSGNEE----LSNLT-NLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPePLGNLTNLKSLDLSNNQ 170
|
90 100
....*....|....*....|....*..
gi 514351402 287 ILT-PSAdfFQSCPRVRELQAGHNPFK 312
Cdd:COG4886 171 LTDlPEE--LGNLTNLKELDLSNNQIT 195
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
133-281 |
3.07e-07 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 51.86 E-value: 3.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351402 133 SSFQYLNFSHNALTDeLFQNCGTLVELKLLILQKNKFESLPKVSfmtsRMKSLKYLDMSNNLLRHDGADVRCQwaeSLTE 212
Cdd:COG4886 205 TNLEELDLSGNQLTD-LPEPLANLTNLETLDLSNNQLTDLPELG----NLTNLEELDLSNNQLTDLPPLANLT---NLKT 276
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 514351402 213 LDLSSNQLADAVFACLPVNVKKLSLQNNQISNVPRGMVELKSLEELNLASNRLADLPGCSGFTSLQFLN 281
Cdd:COG4886 277 LDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLS 345
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
125-309 |
8.83e-07 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 50.56 E-value: 8.83e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351402 125 HMLCPNRTSSFQYLNFSHNALTDE--------LFQNcgtlVELKLLILQKNKF--ESLPKVSFMTSRMKSLKYLDMSNNL 194
Cdd:COG5238 172 SMAKALQNNSVETVYLGCNQIGDEgieelaeaLTQN----TTVTTLWLKRNPIgdEGAEILAEALKGNKSLTTLDLSNNQ 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351402 195 LRHDG----ADVrCQWAESLTELDLSSNQL----ADAVFACLPVN--VKKLSLQNNQISNvpRGMVEL-------KSLEE 257
Cdd:COG5238 248 IGDEGvialAEA-LKNNTTVETLYLSGNQIgaegAIALAKALQGNttLTSLDLSVNRIGD--EGAIALaeglqgnKTLHT 324
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 514351402 258 LNLASNRLADlPGCSGF-------TSLQFLNVEMNSILTPSAD----FFQSCPRVRELQAGHN 309
Cdd:COG5238 325 LNLAYNGIGA-QGAIALakalqenTTLHSLDLSDNQIGDEGAIalakYLEGNTTLRELNLGKN 386
|
|
| LRRCT |
smart00082 |
Leucine rich repeat C-terminal domain; |
309-361 |
1.56e-06 |
|
Leucine rich repeat C-terminal domain;
Pssm-ID: 214507 [Multi-domain] Cd Length: 51 Bit Score: 44.73 E-value: 1.56e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 514351402 309 NPFKCSCELQAFVGLERQSggKLFGWPAAYVCEYPEGLRGtELKDFHLSQLAC 361
Cdd:smart00082 1 NPFICDCELRWLLRWLQAN--EHLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
158-220 |
2.98e-06 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 44.05 E-value: 2.98e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 514351402 158 ELKLLILQKNKFESLPKVSFmtSRMKSLKYLDMSNNLLRHDGADVrCQWAESLTELDLSSNQL 220
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAF--KGLSNLKVLDLSNNLLTTLSPGA-FSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
209-265 |
9.21e-06 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 42.90 E-value: 9.21e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 514351402 209 SLTELDLSSNQL---ADAVFACLPvNVKKLSLQNNQISNV-PRGMVELKSLEELNLASNRL 265
Cdd:pfam13855 2 NLRSLDLSNNRLtslDDGAFKGLS-NLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
159-311 |
1.11e-05 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 45.93 E-value: 1.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351402 159 LKLLILQKNKFESLPKVSFMTSrmksLKYLDMSNNLLRHdgadvrcqwAESLTELdlssnqladavfaclpVNVKKLSLQ 238
Cdd:cd21340 26 LKVLYLYDNKITKIENLEFLTN----LTHLYLQNNQIEK---------IENLENL----------------VNLKKLYLG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351402 239 NNQISNV----------------------------PRGMVEL-KSLEELNLASNRLADLPGCSGFTSLQFLNVEMNSI-- 287
Cdd:cd21340 77 GNRISVVeglenltnleelhienqrlppgekltfdPRSLAALsNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQIsd 156
|
170 180
....*....|....*....|....
gi 514351402 288 LTPSADFFQSCPRVRELQAGHNPF 311
Cdd:cd21340 157 LEELLDLLSSWPSLRELDLTGNPV 180
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
159-311 |
2.77e-05 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 46.23 E-value: 2.77e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351402 159 LKLLILQKNKFESLPKvsfmtSRMKSLKYLDMSNNLLRHDGADVrcqwAESLTELDLSSNQLA----------------D 222
Cdd:PRK15370 264 LQSLDLFHNKISCLPE-----NLPEELRYLSVYDNSIRTLPAHL----PSGITHLNVQSNSLTalpetlppglktleagE 334
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351402 223 AVFACLPVNV----KKLSLQNNQISNVPRGMVelKSLEELNLASNRLADLPGcSGFTSLQFLNVEMNSILT-PSA--DFF 295
Cdd:PRK15370 335 NALTSLPASLppelQVLDVSKNQITVLPETLP--PTITTLDVSRNALTNLPE-NLPAALQIMQASRNNLVRlPESlpHFR 411
|
170
....*....|....*.
gi 514351402 296 QSCPRVRELQAGHNPF 311
Cdd:PRK15370 412 GEGPQPTRIIVEYNPF 427
|
|
| LRR_4 |
pfam12799 |
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ... |
253-294 |
1.57e-04 |
|
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.
Pssm-ID: 463713 [Multi-domain] Cd Length: 44 Bit Score: 38.77 E-value: 1.57e-04
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 514351402 253 KSLEELNLASNRLADLPGCSGFTSLQFLNVEMNSILTPSADF 294
Cdd:pfam12799 1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNKITDLSDL 42
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
131-308 |
7.66e-04 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 41.76 E-value: 7.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351402 131 RTSSFQYLNFSHNALTDELFQNCGTLVELKLLILQKNKFE-SLPKVSFmtsRMKSLKYLDMSNNLLRHDGADVRCQwAES 209
Cdd:PLN00113 234 GLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIF---SLQKLISLDLSDNSLSGEIPELVIQ-LQN 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351402 210 LTELDLSSNQLADAV---FACLPvNVKKLSLQNNQIS-NVPRGMVELKSLEELNLASNRLA-DLPG--CSG--FTSLQFL 280
Cdd:PLN00113 310 LEILHLFSNNFTGKIpvaLTSLP-RLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTgEIPEglCSSgnLFKLILF 388
|
170 180
....*....|....*....|....*...
gi 514351402 281 NVEMNSILTPSADFFQSCPRVReLQAGH 308
Cdd:PLN00113 389 SNSLEGEIPKSLGACRSLRRVR-LQDNS 415
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
131-323 |
8.07e-04 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 41.76 E-value: 8.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351402 131 RTSSFQYLNFSHNALTDELFQNCGTLVELKLLILQKNKFESLpkvsfMTSRMKSLKyldmsnnllrhdgadvrcqwaeSL 210
Cdd:PLN00113 473 GSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGE-----IPDELSSCK----------------------KL 525
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351402 211 TELDLSSNQLAD---AVFACLPVnVKKLSLQNNQIS-NVPRGMVELKSLEELNLASNRL-ADLPGCSGFTSLQFLNVEMN 285
Cdd:PLN00113 526 VSLDLSHNQLSGqipASFSEMPV-LSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHLhGSLPSTGAFLAINASAVAGN 604
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 514351402 286 SIL--TPSADFFQSCPRVRElqaghNP---FKCSCELQAFVGL 323
Cdd:PLN00113 605 IDLcgGDTTSGLPPCKRVRK-----TPswwFYITCTLGAFLVL 642
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
134-193 |
1.71e-03 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 39.38 E-value: 1.71e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351402 134 SFQYLNFSHNALTDelFQNCGTLVELKLLILQKNKFESLPKVSFMTSRMKSLKYLDMSNN 193
Cdd:cd21340 121 SLRVLNISGNNIDS--LEPLAPLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGN 178
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
184-287 |
1.73e-03 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 40.03 E-value: 1.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351402 184 SLKYLDMSNNLLRHDGADVRCQwaesltelDLSSNQladavfaclpvNVKKLSLQNNQISnvPRGMVEL-------KSLE 256
Cdd:cd00116 166 DLKELNLANNGIGDAGIRALAE--------GLKANC-----------NLEVLDLNNNGLT--DEGASALaetlaslKSLE 224
|
90 100 110
....*....|....*....|....*....|....*...
gi 514351402 257 ELNLASNRLADLPGC-------SGFTSLQFLNVEMNSI 287
Cdd:cd00116 225 VLNLGDNNLTDAGAAalasallSPNISLLTLSLSCNDI 262
|
|
| LRR_4 |
pfam12799 |
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ... |
231-270 |
3.86e-03 |
|
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.
Pssm-ID: 463713 [Multi-domain] Cd Length: 44 Bit Score: 34.91 E-value: 3.86e-03
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 514351402 231 NVKKLSLQNNQISNVPrGMVELKSLEELNLASN-RLADLPG 270
Cdd:pfam12799 2 NLEVLDLSNNQITDIP-PLAKLPNLETLDLSGNnKITDLSD 41
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|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
133-311 |
8.29e-03 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 38.29 E-value: 8.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351402 133 SSFQYLNFSHNALTDELFQNCGTLVELKLLILQKNKFesLPKVSFMTSRMKSLKYLDMS-NNLlrhdGADVRCQWAE--S 209
Cdd:PLN00113 164 SSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQL--VGQIPRELGQMKSLKWIYLGyNNL----SGEIPYEIGGltS 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351402 210 LTELDLSSNQLADAVFACLPvNVKKLSL----QNNQISNVPRGMVELKSLEELNLASNRLA-DLPG-CSGFTSLQFLNVE 283
Cdd:PLN00113 238 LNHLDLVYNNLTGPIPSSLG-NLKNLQYlflyQNKLSGPIPPSIFSLQKLISLDLSDNSLSgEIPElVIQLQNLEILHLF 316
|
170 180
....*....|....*....|....*...
gi 514351402 284 MNSILTPSADFFQSCPRVRELQAGHNPF 311
Cdd:PLN00113 317 SNNFTGKIPVALTSLPRLQVLQLWSNKF 344
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