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Conserved domains on  [gi|514351402|gb|AGO49882|]
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Toll-like receptor 1LA, partial [Philesturnus carunculatus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11471445)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
136-312 5.44e-21

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 93.84  E-value: 5.44e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351402 136 QYLNFSHNALTDeLFQNCGTLVELKLLILQKNKFESLPKVsfmTSRMKSLKYLDMSNNLLRHDGADVrcQWAESLTELDL 215
Cdd:COG4886  116 ESLDLSGNQLTD-LPEELANLTNLKELDLSNNQLTDLPEP---LGNLTNLKSLDLSNNQLTDLPEEL--GNLTNLKELDL 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351402 216 SSNQLAD--AVFACLPvNVKKLSLQNNQISNVPRGMVELKSLEELNLASNRLADLPGCSGFTSLQFLNVEMNSI--LTPS 291
Cdd:COG4886  190 SNNQITDlpEPLGNLT-NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLtdLPPL 268

                        170       180
                 ....*....|....*....|.
gi 514351402 292 ADFfqscPRVRELQAGHNPFK 312
Cdd:COG4886  269 ANL----TNLKTLDLSNNQLT 285
LRRCT smart00082
Leucine rich repeat C-terminal domain;
309-361 1.56e-06

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 44.73  E-value: 1.56e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 514351402   309 NPFKCSCELQAFVGLERQSggKLFGWPAAYVCEYPEGLRGtELKDFHLSQLAC 361
Cdd:smart00082   1 NPFICDCELRWLLRWLQAN--EHLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
136-312 5.44e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 93.84  E-value: 5.44e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351402 136 QYLNFSHNALTDeLFQNCGTLVELKLLILQKNKFESLPKVsfmTSRMKSLKYLDMSNNLLRHDGADVrcQWAESLTELDL 215
Cdd:COG4886  116 ESLDLSGNQLTD-LPEELANLTNLKELDLSNNQLTDLPEP---LGNLTNLKSLDLSNNQLTDLPEEL--GNLTNLKELDL 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351402 216 SSNQLAD--AVFACLPvNVKKLSLQNNQISNVPRGMVELKSLEELNLASNRLADLPGCSGFTSLQFLNVEMNSI--LTPS 291
Cdd:COG4886  190 SNNQITDlpEPLGNLT-NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLtdLPPL 268

                        170       180
                 ....*....|....*....|.
gi 514351402 292 ADFfqscPRVRELQAGHNPFK 312
Cdd:COG4886  269 ANL----TNLKTLDLSNNQLT 285
LRRCT smart00082
Leucine rich repeat C-terminal domain;
309-361 1.56e-06

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 44.73  E-value: 1.56e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 514351402   309 NPFKCSCELQAFVGLERQSggKLFGWPAAYVCEYPEGLRGtELKDFHLSQLAC 361
Cdd:smart00082   1 NPFICDCELRWLLRWLQAN--EHLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
LRR_8 pfam13855
Leucine rich repeat;
158-220 2.98e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.05  E-value: 2.98e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 514351402  158 ELKLLILQKNKFESLPKVSFmtSRMKSLKYLDMSNNLLRHDGADVrCQWAESLTELDLSSNQL 220
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAF--KGLSNLKVLDLSNNLLTTLSPGA-FSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 159-311 1.11e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.93  E-value: 1.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351402 159 LKLLILQKNKFESLPKVSFMTSrmksLKYLDMSNNLLRHdgadvrcqwAESLTELdlssnqladavfaclpVNVKKLSLQ 238
Cdd:cd21340   26 LKVLYLYDNKITKIENLEFLTN----LTHLYLQNNQIEK---------IENLENL----------------VNLKKLYLG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351402 239 NNQISNV----------------------------PRGMVEL-KSLEELNLASNRLADLPGCSGFTSLQFLNVEMNSI-- 287
Cdd:cd21340   77 GNRISVVeglenltnleelhienqrlppgekltfdPRSLAALsNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQIsd 156

                        170       180
                 ....*....|....*....|....
gi 514351402 288 LTPSADFFQSCPRVRELQAGHNPF 311
Cdd:cd21340  157 LEELLDLLSSWPSLRELDLTGNPV 180
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
159-311 2.77e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 46.23  E-value: 2.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351402 159 LKLLILQKNKFESLPKvsfmtSRMKSLKYLDMSNNLLRHDGADVrcqwAESLTELDLSSNQLA----------------D 222
Cdd:PRK15370 264 LQSLDLFHNKISCLPE-----NLPEELRYLSVYDNSIRTLPAHL----PSGITHLNVQSNSLTalpetlppglktleagE 334

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351402 223 AVFACLPVNV----KKLSLQNNQISNVPRGMVelKSLEELNLASNRLADLPGcSGFTSLQFLNVEMNSILT-PSA--DFF 295
Cdd:PRK15370 335 NALTSLPASLppelQVLDVSKNQITVLPETLP--PTITTLDVSRNALTNLPE-NLPAALQIMQASRNNLVRlPESlpHFR 411

                        170
                 ....*....|....*.
gi 514351402 296 QSCPRVRELQAGHNPF 311
Cdd:PRK15370 412 GEGPQPTRIIVEYNPF 427
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
136-312 5.44e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 93.84  E-value: 5.44e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351402 136 QYLNFSHNALTDeLFQNCGTLVELKLLILQKNKFESLPKVsfmTSRMKSLKYLDMSNNLLRHDGADVrcQWAESLTELDL 215
Cdd:COG4886  116 ESLDLSGNQLTD-LPEELANLTNLKELDLSNNQLTDLPEP---LGNLTNLKSLDLSNNQLTDLPEEL--GNLTNLKELDL 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351402 216 SSNQLAD--AVFACLPvNVKKLSLQNNQISNVPRGMVELKSLEELNLASNRLADLPGCSGFTSLQFLNVEMNSI--LTPS 291
Cdd:COG4886  190 SNNQITDlpEPLGNLT-NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLtdLPPL 268

                        170       180
                 ....*....|....*....|.
gi 514351402 292 ADFfqscPRVRELQAGHNPFK 312
Cdd:COG4886  269 ANL----TNLKTLDLSNNQLT 285
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
154-312 1.19e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 80.75  E-value: 1.19e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351402 154 GTLVELKLLILQKNKFESLPKVsfmTSRMKSLKYLDMSNNLLRHDGADVRCqwAESLTELDLSSNQLAD--AVFACLPvN 231
Cdd:COG4886  110 SNLTNLESLDLSGNQLTDLPEE---LANLTNLKELDLSNNQLTDLPEPLGN--LTNLKSLDLSNNQLTDlpEELGNLT-N 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351402 232 VKKLSLQNNQISNVPRGMVELKSLEELNLASNRLADLPGC-SGFTSLQFLNVEMNSIltPSADFFQSCPRVRELQAGHNP 310
Cdd:COG4886  184 LKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPlANLTNLETLDLSNNQL--TDLPELGNLTNLEELDLSNNQ 261


                 ..
gi 514351402 311 FK 312
Cdd:COG4886  262 LT 263
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
208-312 5.77e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 57.25  E-value: 5.77e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351402 208 ESLTELDLSSNQLadavFACLPvNVKKLSLQNNQISNVPRGMVELKSLEELNLASNRLADLP-GCSGFTSLQFLNVEMNS 286
Cdd:COG4886   96 TNLTELDLSGNEE----LSNLT-NLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPePLGNLTNLKSLDLSNNQ 170

                         90       100
                 ....*....|....*....|....*..
gi 514351402 287 ILT-PSAdfFQSCPRVRELQAGHNPFK 312
Cdd:COG4886  171 LTDlPEE--LGNLTNLKELDLSNNQIT 195
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
133-281 3.07e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.86  E-value: 3.07e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351402 133 SSFQYLNFSHNALTDeLFQNCGTLVELKLLILQKNKFESLPKVSfmtsRMKSLKYLDMSNNLLRHDGADVRCQwaeSLTE 212
Cdd:COG4886  205 TNLEELDLSGNQLTD-LPEPLANLTNLETLDLSNNQLTDLPELG----NLTNLEELDLSNNQLTDLPPLANLT---NLKT 276

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 514351402 213 LDLSSNQLADAVFACLPVNVKKLSLQNNQISNVPRGMVELKSLEELNLASNRLADLPGCSGFTSLQFLN 281
Cdd:COG4886  277 LDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLS 345
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 125-309 8.83e-07

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 50.56  E-value: 8.83e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351402 125 HMLCPNRTSSFQYLNFSHNALTDE--------LFQNcgtlVELKLLILQKNKF--ESLPKVSFMTSRMKSLKYLDMSNNL 194
Cdd:COG5238  172 SMAKALQNNSVETVYLGCNQIGDEgieelaeaLTQN----TTVTTLWLKRNPIgdEGAEILAEALKGNKSLTTLDLSNNQ 247

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351402 195 LRHDG----ADVrCQWAESLTELDLSSNQL----ADAVFACLPVN--VKKLSLQNNQISNvpRGMVEL-------KSLEE 257
Cdd:COG5238  248 IGDEGvialAEA-LKNNTTVETLYLSGNQIgaegAIALAKALQGNttLTSLDLSVNRIGD--EGAIALaeglqgnKTLHT 324

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 514351402 258 LNLASNRLADlPGCSGF-------TSLQFLNVEMNSILTPSAD----FFQSCPRVRELQAGHN 309
Cdd:COG5238  325 LNLAYNGIGA-QGAIALakalqenTTLHSLDLSDNQIGDEGAIalakYLEGNTTLRELNLGKN 386
LRRCT smart00082
Leucine rich repeat C-terminal domain;
309-361 1.56e-06

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 44.73  E-value: 1.56e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 514351402   309 NPFKCSCELQAFVGLERQSggKLFGWPAAYVCEYPEGLRGtELKDFHLSQLAC 361
Cdd:smart00082   1 NPFICDCELRWLLRWLQAN--EHLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
LRR_8 pfam13855
Leucine rich repeat;
158-220 2.98e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.05  E-value: 2.98e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 514351402  158 ELKLLILQKNKFESLPKVSFmtSRMKSLKYLDMSNNLLRHDGADVrCQWAESLTELDLSSNQL 220
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAF--KGLSNLKVLDLSNNLLTTLSPGA-FSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
209-265 9.21e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.90  E-value: 9.21e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 514351402  209 SLTELDLSSNQL---ADAVFACLPvNVKKLSLQNNQISNV-PRGMVELKSLEELNLASNRL 265
Cdd:pfam13855   2 NLRSLDLSNNRLtslDDGAFKGLS-NLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 159-311 1.11e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.93  E-value: 1.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351402 159 LKLLILQKNKFESLPKVSFMTSrmksLKYLDMSNNLLRHdgadvrcqwAESLTELdlssnqladavfaclpVNVKKLSLQ 238
Cdd:cd21340   26 LKVLYLYDNKITKIENLEFLTN----LTHLYLQNNQIEK---------IENLENL----------------VNLKKLYLG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351402 239 NNQISNV----------------------------PRGMVEL-KSLEELNLASNRLADLPGCSGFTSLQFLNVEMNSI-- 287
Cdd:cd21340   77 GNRISVVeglenltnleelhienqrlppgekltfdPRSLAALsNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQIsd 156

                        170       180
                 ....*....|....*....|....
gi 514351402 288 LTPSADFFQSCPRVRELQAGHNPF 311
Cdd:cd21340  157 LEELLDLLSSWPSLRELDLTGNPV 180
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
159-311 2.77e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 46.23  E-value: 2.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351402 159 LKLLILQKNKFESLPKvsfmtSRMKSLKYLDMSNNLLRHDGADVrcqwAESLTELDLSSNQLA----------------D 222
Cdd:PRK15370 264 LQSLDLFHNKISCLPE-----NLPEELRYLSVYDNSIRTLPAHL----PSGITHLNVQSNSLTalpetlppglktleagE 334

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351402 223 AVFACLPVNV----KKLSLQNNQISNVPRGMVelKSLEELNLASNRLADLPGcSGFTSLQFLNVEMNSILT-PSA--DFF 295
Cdd:PRK15370 335 NALTSLPASLppelQVLDVSKNQITVLPETLP--PTITTLDVSRNALTNLPE-NLPAALQIMQASRNNLVRlPESlpHFR 411

                        170
                 ....*....|....*.
gi 514351402 296 QSCPRVRELQAGHNPF 311
Cdd:PRK15370 412 GEGPQPTRIIVEYNPF 427
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 253-294 1.57e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.77  E-value: 1.57e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 514351402  253 KSLEELNLASNRLADLPGCSGFTSLQFLNVEMNSILTPSADF 294
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNKITDLSDL 42
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 131-308 7.66e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.76  E-value: 7.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351402 131 RTSSFQYLNFSHNALTDELFQNCGTLVELKLLILQKNKFE-SLPKVSFmtsRMKSLKYLDMSNNLLRHDGADVRCQwAES 209
Cdd:PLN00113 234 GLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIF---SLQKLISLDLSDNSLSGEIPELVIQ-LQN 309

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351402 210 LTELDLSSNQLADAV---FACLPvNVKKLSLQNNQIS-NVPRGMVELKSLEELNLASNRLA-DLPG--CSG--FTSLQFL 280
Cdd:PLN00113 310 LEILHLFSNNFTGKIpvaLTSLP-RLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTgEIPEglCSSgnLFKLILF 388

                        170       180
                 ....*....|....*....|....*...
gi 514351402 281 NVEMNSILTPSADFFQSCPRVReLQAGH 308
Cdd:PLN00113 389 SNSLEGEIPKSLGACRSLRRVR-LQDNS 415
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 131-323 8.07e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.76  E-value: 8.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351402 131 RTSSFQYLNFSHNALTDELFQNCGTLVELKLLILQKNKFESLpkvsfMTSRMKSLKyldmsnnllrhdgadvrcqwaeSL 210
Cdd:PLN00113 473 GSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGE-----IPDELSSCK----------------------KL 525

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351402 211 TELDLSSNQLAD---AVFACLPVnVKKLSLQNNQIS-NVPRGMVELKSLEELNLASNRL-ADLPGCSGFTSLQFLNVEMN 285
Cdd:PLN00113 526 VSLDLSHNQLSGqipASFSEMPV-LSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHLhGSLPSTGAFLAINASAVAGN 604

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 514351402 286 SIL--TPSADFFQSCPRVRElqaghNP---FKCSCELQAFVGL 323
Cdd:PLN00113 605 IDLcgGDTTSGLPPCKRVRK-----TPswwFYITCTLGAFLVL 642
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 134-193 1.71e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.38  E-value: 1.71e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351402 134 SFQYLNFSHNALTDelFQNCGTLVELKLLILQKNKFESLPKVSFMTSRMKSLKYLDMSNN 193
Cdd:cd21340  121 SLRVLNISGNNIDS--LEPLAPLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGN 178
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 184-287 1.73e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.03  E-value: 1.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351402 184 SLKYLDMSNNLLRHDGADVRCQwaesltelDLSSNQladavfaclpvNVKKLSLQNNQISnvPRGMVEL-------KSLE 256
Cdd:cd00116  166 DLKELNLANNGIGDAGIRALAE--------GLKANC-----------NLEVLDLNNNGLT--DEGASALaetlaslKSLE 224

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 514351402 257 ELNLASNRLADLPGC-------SGFTSLQFLNVEMNSI 287
Cdd:cd00116  225 VLNLGDNNLTDAGAAalasallSPNISLLTLSLSCNDI 262
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 231-270 3.86e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.91  E-value: 3.86e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 514351402  231 NVKKLSLQNNQISNVPrGMVELKSLEELNLASN-RLADLPG 270
Cdd:pfam12799   2 NLEVLDLSNNQITDIP-PLAKLPNLETLDLSGNnKITDLSD 41
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 133-311 8.29e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 38.29  E-value: 8.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351402 133 SSFQYLNFSHNALTDELFQNCGTLVELKLLILQKNKFesLPKVSFMTSRMKSLKYLDMS-NNLlrhdGADVRCQWAE--S 209
Cdd:PLN00113 164 SSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQL--VGQIPRELGQMKSLKWIYLGyNNL----SGEIPYEIGGltS 237

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351402 210 LTELDLSSNQLADAVFACLPvNVKKLSL----QNNQISNVPRGMVELKSLEELNLASNRLA-DLPG-CSGFTSLQFLNVE 283
Cdd:PLN00113 238 LNHLDLVYNNLTGPIPSSLG-NLKNLQYlflyQNKLSGPIPPSIFSLQKLISLDLSDNSLSgEIPElVIQLQNLEILHLF 316

                        170       180
                 ....*....|....*....|....*...
gi 514351402 284 MNSILTPSADFFQSCPRVRELQAGHNPF 311
Cdd:PLN00113 317 SNNFTGKIPVALTSLPRLQVLQLWSNKF 344
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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