NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|514351406|gb|AGO49884|]
View 

Toll-like receptor 1LA, partial [Porphyrio hochstetteri]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11471445)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
138-289 2.30e-19

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 89.22  E-value: 2.30e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351406 138 QYLNFSRNALTDeLFQNCGTLTDLKFLILQRNKFESLLKVsfmTSRMTSLKHLDMSRNLLRhDVADTQCQWaESLTELDL 217
Cdd:COG4886  116 ESLDLSGNQLTD-LPEELANLTNLKELDLSNNQLTDLPEP---LGNLTNLKSLDLSNNQLT-DLPEELGNL-TNLKELDL 189

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 514351406 218 SSNQLTD--AVFACLPvNVKRLDLQNNQITSVPTGMAELKSLAELNLAANRLADLPGCGGFVSLEYLNVEMNSI 289
Cdd:COG4886  190 SNNQITDlpEPLGNLT-NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQL 262
LRRCT smart00082
Leucine rich repeat C-terminal domain;
311-363 1.89e-07

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 47.42  E-value: 1.89e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 514351406   311 NPFKCSCELQEFIRVERQSggRLFGWPAAYTCEYPEDLRGtQLKDFHLSELAC 363
Cdd:smart00082   1 NPFICDCELRWLLRWLQAN--EHLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
138-289 2.30e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 89.22  E-value: 2.30e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351406 138 QYLNFSRNALTDeLFQNCGTLTDLKFLILQRNKFESLLKVsfmTSRMTSLKHLDMSRNLLRhDVADTQCQWaESLTELDL 217
Cdd:COG4886  116 ESLDLSGNQLTD-LPEELANLTNLKELDLSNNQLTDLPEP---LGNLTNLKSLDLSNNQLT-DLPEELGNL-TNLKELDL 189

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 514351406 218 SSNQLTD--AVFACLPvNVKRLDLQNNQITSVPTGMAELKSLAELNLAANRLADLPGCGGFVSLEYLNVEMNSI 289
Cdd:COG4886  190 SNNQITDlpEPLGNLT-NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQL 262
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 139-287 7.01e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 61.02  E-value: 7.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351406 139 YLNFSRNALTDELFQNCGTLTDLKFLILQRNKFESLLKVSFMTSRmtsLKHLDMSRNLLRHDVADTQCQWAEsLTELDLS 218
Cdd:PLN00113 432 FLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLPDSFGSKR---LENLDLSRNQFSGAVPRKLGSLSE-LMQLKLS 507

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 514351406 219 SNQLT----DAVFAClpVNVKRLDLQNNQIT-SVPTGMAELKSLAELNLAANRLA-DLP-GCGGFVSLEYLNVEMN 287
Cdd:PLN00113 508 ENKLSgeipDELSSC--KKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLSgEIPkNLGNVESLVQVNISHN 581
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 72-271 6.05e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 53.90  E-value: 6.05e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351406  72 LLGSLEHVISLGGSMKGLTLEHVR--NKVYYFNQEILYRQFSEMNVTSLTIYDACMPHMLcpNRTSSFQYLNFSRNALTD 149
Cdd:cd00116   18 LLPKLLCLQVLRLEGNTLGEEAAKalASALRPQPSLKELCLSLNETGRIPRGLQSLLQGL--TKGCGLQELDLSDNALGP 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351406 150 EL---FQNCGTLTDLKFLILQRNKFESL---LKVSFMTSRMTSLKHLDMSRNLLRHDVADtqcQWAE------SLTELDL 217
Cdd:cd00116   96 DGcgvLESLLRSSSLQELKLNNNGLGDRglrLLAKGLKDLPPALEKLVLGRNRLEGASCE---ALAKalranrDLKELNL 172

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 514351406 218 SSNQLTDAVFACLPV------NVKRLDLQNNQITsvPTGM-------AELKSLAELNLAANRLADLP 271
Cdd:cd00116  173 ANNGIGDAGIRALAEglkancNLEVLDLNNNGLT--DEGAsalaetlASLKSLEVLNLGDNNLTDAG 237
LRRCT smart00082
Leucine rich repeat C-terminal domain;
311-363 1.89e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 47.42  E-value: 1.89e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 514351406   311 NPFKCSCELQEFIRVERQSggRLFGWPAAYTCEYPEDLRGtQLKDFHLSELAC 363
Cdd:smart00082   1 NPFICDCELRWLLRWLQAN--EHLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
LRR_8 pfam13855
Leucine rich repeat;
161-222 3.36e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.27  E-value: 3.36e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 514351406  161 LKFLILQRNKFESLLKVSFmtSRMTSLKHLDMSRNLLRHDVADTqCQWAESLTELDLSSNQL 222
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAF--KGLSNLKVLDLSNNLLTTLSPGA-FSGLPSLRYLDLSGNRL 61
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 287-364 1.78e-03

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 40.84  E-value: 1.78e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 514351406   287 NSILTPSADFFQRCPRVRELQAGQNPFKCSCELQEFIRVERQSGGRLFGwPAAYTCEYPEDLRGTQLKDFHLSELACN 364
Cdd:TIGR00864    5 NKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQ-PEAALCAGPGALAGQPLLGIPLLDSGCD 81
LRRCT pfam01463
Leucine rich repeat C-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 339-363 4.13e-03

Leucine rich repeat C-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the C-terminus of tandem leucine rich repeats.


Pssm-ID: 279765  Cd Length: 26  Bit Score: 34.33  E-value: 4.13e-03
                          10        20
                  ....*....|....*....|....*
gi 514351406  339 AYTCEYPEDLRGTQLKDFHLSELAC 363
Cdd:pfam01463   1 NARCASPPRLRGQPLLDLLPSDFSC 25
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
138-289 2.30e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 89.22  E-value: 2.30e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351406 138 QYLNFSRNALTDeLFQNCGTLTDLKFLILQRNKFESLLKVsfmTSRMTSLKHLDMSRNLLRhDVADTQCQWaESLTELDL 217
Cdd:COG4886  116 ESLDLSGNQLTD-LPEELANLTNLKELDLSNNQLTDLPEP---LGNLTNLKSLDLSNNQLT-DLPEELGNL-TNLKELDL 189

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 514351406 218 SSNQLTD--AVFACLPvNVKRLDLQNNQITSVPTGMAELKSLAELNLAANRLADLPGCGGFVSLEYLNVEMNSI 289
Cdd:COG4886  190 SNNQITDlpEPLGNLT-NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQL 262
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 139-287 7.01e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 61.02  E-value: 7.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351406 139 YLNFSRNALTDELFQNCGTLTDLKFLILQRNKFESLLKVSFMTSRmtsLKHLDMSRNLLRHDVADTQCQWAEsLTELDLS 218
Cdd:PLN00113 432 FLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLPDSFGSKR---LENLDLSRNQFSGAVPRKLGSLSE-LMQLKLS 507

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 514351406 219 SNQLT----DAVFAClpVNVKRLDLQNNQIT-SVPTGMAELKSLAELNLAANRLA-DLP-GCGGFVSLEYLNVEMN 287
Cdd:PLN00113 508 ENKLSgeipDELSSC--KKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLSgEIPkNLGNVESLVQVNISHN 581
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
193-314 9.12e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.87  E-value: 9.12e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351406 193 SRNLLRHDVADTQCQWAESLTELDLSSNQLTDAVfaclpVNVKRLDLQNNQITSVPTGMAELKSLAELNLAANRLADLP- 271
Cdd:COG4886   79 LLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNL-----TNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPe 153

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 514351406 272 GCGGFVSLEYLNVEMNSILT-PSAdfFQRCPRVRELQAGQNPFK 314
Cdd:COG4886  154 PLGNLTNLKSLDLSNNQLTDlPEE--LGNLTNLKELDLSNNQIT 195
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 72-271 6.05e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 53.90  E-value: 6.05e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351406  72 LLGSLEHVISLGGSMKGLTLEHVR--NKVYYFNQEILYRQFSEMNVTSLTIYDACMPHMLcpNRTSSFQYLNFSRNALTD 149
Cdd:cd00116   18 LLPKLLCLQVLRLEGNTLGEEAAKalASALRPQPSLKELCLSLNETGRIPRGLQSLLQGL--TKGCGLQELDLSDNALGP 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351406 150 EL---FQNCGTLTDLKFLILQRNKFESL---LKVSFMTSRMTSLKHLDMSRNLLRHDVADtqcQWAE------SLTELDL 217
Cdd:cd00116   96 DGcgvLESLLRSSSLQELKLNNNGLGDRglrLLAKGLKDLPPALEKLVLGRNRLEGASCE---ALAKalranrDLKELNL 172

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 514351406 218 SSNQLTDAVFACLPV------NVKRLDLQNNQITsvPTGM-------AELKSLAELNLAANRLADLP 271
Cdd:cd00116  173 ANNGIGDAGIRALAEglkancNLEVLDLNNNGLT--DEGAsalaetlASLKSLEVLNLGDNNLTDAG 237
LRRCT smart00082
Leucine rich repeat C-terminal domain;
311-363 1.89e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 47.42  E-value: 1.89e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 514351406   311 NPFKCSCELQEFIRVERQSggRLFGWPAAYTCEYPEDLRGtQLKDFHLSELAC 363
Cdd:smart00082   1 NPFICDCELRWLLRWLQAN--EHLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 133-305 1.86e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 50.23  E-value: 1.86e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351406 133 RTSSFQYLNFSrnaltdelfqncgtltdlkflilqRNKFESLLKVSFMTsrMTSLKHLDMSRNLLRHDVAD--TQCqwaE 210
Cdd:PLN00113 473 GSKRLENLDLS------------------------RNQFSGAVPRKLGS--LSELMQLKLSENKLSGEIPDelSSC---K 523

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351406 211 SLTELDLSSNQLTD---AVFACLPVnVKRLDLQNNQIT-SVPTGMAELKSLAELNLAANRL-ADLPGCGGFVSLEYLNVE 285
Cdd:PLN00113 524 KLVSLDLSHNQLSGqipASFSEMPV-LSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHLhGSLPSTGAFLAINASAVA 602

                        170       180
                 ....*....|....*....|..
gi 514351406 286 MNSIL--TPSADFFQRCPRVRE 305
Cdd:PLN00113 603 GNIDLcgGDTTSGLPPCKRVRK 624
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 153-313 4.66e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.01  E-value: 4.66e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351406 153 QNCGTLTDLKFLILQRNKFESLLkvsfMTSRMTSLKHLDMSRNLLRHdVADTQCQwaESLTELDLSSNQLTDavfaclpv 232
Cdd:cd21340   40 ENLEFLTNLTHLYLQNNQIEKIE----NLENLVNLKKLYLGGNRISV-VEGLENL--TNLEELHIENQRLPP-------- 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351406 233 nvkrldlqNNQITSVP-TGMAELKSLAELNLAANRLADLPGCGGFVSLEYLNVEMNSI--LTPSADFFQRCPRVRELQAG 309
Cdd:cd21340  105 --------GEKLTFDPrSLAALSNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQIsdLEELLDLLSSWPSLRELDLT 176


                 ....
gi 514351406 310 QNPF 313
Cdd:cd21340  177 GNPV 180
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
135-270 5.25e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 44.92  E-value: 5.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351406 135 SSFQYLNFSRNALTDeLFQNCGTLTDLKFLILQRNKFESLLKVSfmtsRMTSLKHLDMSRNLLRHDVADTQCQwaeSLTE 214
Cdd:COG4886  205 TNLEELDLSGNQLTD-LPEPLANLTNLETLDLSNNQLTDLPELG----NLTNLEELDLSNNQLTDLPPLANLT---NLKT 276

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 514351406 215 LDLSSNQLTDAVFACLPVNVKRLDLQNNQITSVPTGMAELKSLAELNLAANRLADL 270
Cdd:COG4886  277 LDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKG 332
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 133-267 8.25e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.84  E-value: 8.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351406 133 RTSSFQYLNFSRNALTDELFQNCGTLTDLKFLILQRNKFESLLKVSFMTsrMTSLKHLDMSRNLLRHDVADTQCQwAESL 212
Cdd:PLN00113 234 GLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFS--LQKLISLDLSDNSLSGEIPELVIQ-LQNL 310

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 514351406 213 TELDLSSNQLTDAV---FACLPvNVKRLDLQNNQIT-SVPTGMAELKSLAELNLAANRL 267
Cdd:PLN00113 311 EILHLFSNNFTGKIpvaLTSLP-RLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNL 368
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 211-269 2.40e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 42.85  E-value: 2.40e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351406 211 SLTELDLSSNQLTDAVFACL------PVNVKRLDLQNNQIT-----SVPTGMAELKSLAELNLAANRLAD 269
Cdd:COG5238  237 SLTTLDLSNNQIGDEGVIALaealknNTTVETLYLSGNQIGaegaiALAKALQGNTTLTSLDLSVNRIGD 306
LRR_8 pfam13855
Leucine rich repeat;
161-222 3.36e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.27  E-value: 3.36e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 514351406  161 LKFLILQRNKFESLLKVSFmtSRMTSLKHLDMSRNLLRHDVADTqCQWAESLTELDLSSNQL 222
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAF--KGLSNLKVLDLSNNLLTTLSPGA-FSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 135-268 1.06e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.37  E-value: 1.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351406 135 SSFQYLNFSRNALTDELFQNCGTLTDLKFLILQRNKFESLLKVSFmtSRMTSLKHLDMSRNLLRHDVAdTQCQWAESLTE 214
Cdd:PLN00113 164 SSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPREL--GQMKSLKWIYLGYNNLSGEIP-YEIGGLTSLNH 240

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 514351406 215 LDLSSNQLTDAVFACLPvNVKRLDL----QNNQITSVPTGMAELKSLAELNLAANRLA 268
Cdd:PLN00113 241 LDLVYNNLTGPIPSSLG-NLKNLQYlflyQNKLSGPIPPSIFSLQKLISLDLSDNSLS 297
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 185-269 1.11e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.42  E-value: 1.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351406 185 TSLKHLDMSRNLLRH----DVADTQCQWAeSLTELDLSSNQLTDAVFACL-------PVNVKRLDLQNNQIT-----SVP 248
Cdd:cd00116  193 CNLEVLDLNNNGLTDegasALAETLASLK-SLEVLNLGDNNLTDAGAAALasallspNISLLTLSLSCNDITddgakDLA 271

                         90       100
                 ....*....|....*....|.
gi 514351406 249 TGMAELKSLAELNLAANRLAD 269
Cdd:cd00116  272 EVLAEKESLLELDLRGNKFGE 292
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 287-364 1.78e-03

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 40.84  E-value: 1.78e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 514351406   287 NSILTPSADFFQRCPRVRELQAGQNPFKCSCELQEFIRVERQSGGRLFGwPAAYTCEYPEDLRGTQLKDFHLSELACN 364
Cdd:TIGR00864    5 NKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQ-PEAALCAGPGALAGQPLLGIPLLDSGCD 81
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
212-271 1.80e-03

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 40.53  E-value: 1.80e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351406 212 LTELDLSSNQLtdAVFACLPVNVKRLDLQNNQITSVPTGMAELKslaELNLAANRLADLP 271
Cdd:PRK15387 304 LQELSVSDNQL--ASLPALPSELCKLWAYNNQLTSLPTLPSGLQ---ELSVSDNQLASLP 358
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 176-289 2.13e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.22  E-value: 2.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351406 176 KVSFMTSRMTSLKHLDMSRNLLRHDVADTQCQWAESLTELDLSSNQLTDAVFACLPVNVKRLDLQNNQIT-SVPTGMAEL 254
Cdd:PLN00113  84 KISSAIFRLPYIQTINLSNNQLSGPIPDDIFTTSSSLRYLNLSNNNFTGSIPRGSIPNLETLDLSNNMLSgEIPNDIGSF 163

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 514351406 255 KSLAELNLAANRL-ADLPG-CGGFVSLEYLNVEMNSI 289
Cdd:PLN00113 164 SSLKVLDLGGNVLvGKIPNsLTNLTSLEFLTLASNQL 200
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 136-195 2.48e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.00  E-value: 2.48e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351406 136 SFQYLNFSRNALTDelFQNCGTLTDLKFLILQRNKFESLLKVSFMTSRMTSLKHLDMSRN 195
Cdd:cd21340  121 SLRVLNISGNNIDS--LEPLAPLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
185-244 3.05e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.58  E-value: 3.05e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 514351406  185 TSLKHLDMSRNLLrHDVADTQCQWAESLTELDLSSNQLT---DAVFACLPvNVKRLDLQNNQI 244
Cdd:pfam13855   1 PNLRSLDLSNNRL-TSLDDGAFKGLSNLKVLDLSNNLLTtlsPGAFSGLP-SLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
233-289 3.86e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.58  E-value: 3.86e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351406  233 NVKRLDLQNNQITSVPTGMAE-LKSLAELNLAANRLADLPG--CGGFVSLEYLNVEMNSI 289
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRRCT pfam01463
Leucine rich repeat C-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 339-363 4.13e-03

Leucine rich repeat C-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the C-terminus of tandem leucine rich repeats.


Pssm-ID: 279765  Cd Length: 26  Bit Score: 34.33  E-value: 4.13e-03
                          10        20
                  ....*....|....*....|....*
gi 514351406  339 AYTCEYPEDLRGTQLKDFHLSELAC 363
Cdd:pfam01463   1 NARCASPPRLRGQPLLDLLPSDFSC 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH