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Conserved domains on  [gi|514351430|gb|AGO49896|]
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Toll-like receptor 2B, partial [Apteryx mantelli mantelli]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 18784505)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-311 3.80e-20

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 91.53  E-value: 3.80e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351430  52 KDCRLLGTGQWSTQIHINQSRSLRVVTIEKLSIEEFYLFSDLTAVLDIVSpLTKVTVKDTKVFLVPCRLSQrLLSLEYLD 131
Cdd:COG4886   65 LLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTN-LESLDLSGNQLTDLPEELAN-LTNLKELD 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351430 132 LSENLL*D--QSLahsacqGGWPJLQILNLSQNSLSDLkmtGKSLSHLRNLILLDISQNNFGEIPDTCQWPGNLKHLNLS 209
Cdd:COG4886  143 LSNNQLTDlpEPL------GNLTNLKSLDLSNNQLTDL---PEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLS 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351430 210 TSQIPKLTTCIP-LT-LEVLDVSANSLKEFG--LQLPFLKELYIAKNQLKTLPDAAPIPSLVAMTIRGNKLNSFSKEEFE 285
Cdd:COG4886  214 GNQLTDLPEPLAnLTnLETLDLSNNQLTDLPelGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELE 293

                        250       260
                 ....*....|....*....|....*.
gi 514351430 286 SFKKMEMLDASDNNFICSCEFLSFIH 311
Cdd:COG4886  294 LLLGLNSLLLLLLLLNLLELLILLLL 319
LRRCT super family cl47026
Leucine rich repeat C-terminal domain;
298-351 2.87e-03

Leucine rich repeat C-terminal domain;


The actual alignment was detected with superfamily member smart00082:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 35.48  E-value: 2.87e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 514351430   298 NNFICSCEFLSFIHHQagIAQILARWPESYICDSPLAVRGeQVGAVHLSLMECH 351
Cdd:smart00082   1 NPFICDCELRWLLRWL--QANEHLQDPVDLRCASPSSLRG-PLLELLHSEFKCP 51
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-311 3.80e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 91.53  E-value: 3.80e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351430  52 KDCRLLGTGQWSTQIHINQSRSLRVVTIEKLSIEEFYLFSDLTAVLDIVSpLTKVTVKDTKVFLVPCRLSQrLLSLEYLD 131
Cdd:COG4886   65 LLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTN-LESLDLSGNQLTDLPEELAN-LTNLKELD 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351430 132 LSENLL*D--QSLahsacqGGWPJLQILNLSQNSLSDLkmtGKSLSHLRNLILLDISQNNFGEIPDTCQWPGNLKHLNLS 209
Cdd:COG4886  143 LSNNQLTDlpEPL------GNLTNLKSLDLSNNQLTDL---PEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLS 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351430 210 TSQIPKLTTCIP-LT-LEVLDVSANSLKEFG--LQLPFLKELYIAKNQLKTLPDAAPIPSLVAMTIRGNKLNSFSKEEFE 285
Cdd:COG4886  214 GNQLTDLPEPLAnLTnLETLDLSNNQLTDLPelGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELE 293

                        250       260
                 ....*....|....*....|....*.
gi 514351430 286 SFKKMEMLDASDNNFICSCEFLSFIH 311
Cdd:COG4886  294 LLLGLNSLLLLLLLLNLLELLILLLL 319
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
154-301 1.23e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 60.10  E-value: 1.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351430 154 LQILNLSQNSLSDLKMTGKSlshlrNLILLDISQNNFGEIPDtcQWPGNLKHLNLSTSQIPKLTTCIPLTLEVLDVSANS 233
Cdd:PRK15370 264 LQSLDLFHNKISCLPENLPE-----ELRYLSVYDNSIRTLPA--HLPSGITHLNVQSNSLTALPETLPPGLKTLEAGENA 336

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 514351430 234 LKEFGLQL-PFLKELYIAKNQLKTLPDAAPiPSLVAMTIRGNKLNSFSKEEFESFKKMEmldASDNNFI 301
Cdd:PRK15370 337 LTSLPASLpPELQVLDVSKNQITVLPETLP-PTITTLDVSRNALTNLPENLPAALQIMQ---ASRNNLV 401
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 122-209 2.95e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.94  E-value: 2.95e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351430 122 QRLLSLEYLDLSENLL*dQSLAHSacqggwpjLQILNLSQNSLSDLKmtgkSLSHLRNLILLDISQNNFGEIPDTCQ--- 198
Cdd:cd21340  100 QRLPPGEKLTFDPRSL--AALSNS--------LRVLNISGNNIDSLE----PLAPLRNLEQLDASNNQISDLEELLDlls 165

                         90
                 ....*....|..
gi 514351430 199 -WPgNLKHLNLS 209
Cdd:cd21340  166 sWP-SLRELDLT 176
LRR_8 pfam13855
Leucine rich repeat;
126-190 3.22e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 3.22e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 514351430  126 SLEYLDLSENLL*dQSLAHSACQGgWPJLQILNLSQNSLSDLkmTGKSLSHLRNLILLDISQNNF 190
Cdd:pfam13855   2 NLRSLDLSNNRL--TSLDDGAFKG-LSNLKVLDLSNNLLTTL--SPGAFSGLPSLRYLDLSGNRL 61
LRRCT smart00082
Leucine rich repeat C-terminal domain;
298-351 2.87e-03

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 35.48  E-value: 2.87e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 514351430   298 NNFICSCEFLSFIHHQagIAQILARWPESYICDSPLAVRGeQVGAVHLSLMECH 351
Cdd:smart00082   1 NPFICDCELRWLLRWL--QANEHLQDPVDLRCASPSSLRG-PLLELLHSEFKCP 51
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-311 3.80e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 91.53  E-value: 3.80e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351430  52 KDCRLLGTGQWSTQIHINQSRSLRVVTIEKLSIEEFYLFSDLTAVLDIVSpLTKVTVKDTKVFLVPCRLSQrLLSLEYLD 131
Cdd:COG4886   65 LLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTN-LESLDLSGNQLTDLPEELAN-LTNLKELD 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351430 132 LSENLL*D--QSLahsacqGGWPJLQILNLSQNSLSDLkmtGKSLSHLRNLILLDISQNNFGEIPDTCQWPGNLKHLNLS 209
Cdd:COG4886  143 LSNNQLTDlpEPL------GNLTNLKSLDLSNNQLTDL---PEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLS 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351430 210 TSQIPKLTTCIP-LT-LEVLDVSANSLKEFG--LQLPFLKELYIAKNQLKTLPDAAPIPSLVAMTIRGNKLNSFSKEEFE 285
Cdd:COG4886  214 GNQLTDLPEPLAnLTnLETLDLSNNQLTDLPelGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELE 293

                        250       260
                 ....*....|....*....|....*.
gi 514351430 286 SFKKMEMLDASDNNFICSCEFLSFIH 311
Cdd:COG4886  294 LLLGLNSLLLLLLLLNLLELLILLLL 319
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
56-300 1.20e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 89.99  E-value: 1.20e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351430  56 LLGTGQWSTQIHINQSRSLRVVTIEKLSIEEFYLFSDLTAVLDIVSPLTKVTVKDTKVFLVPCRLSQRLLSLEYLDLSEN 135
Cdd:COG4886   27 LLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351430 136 LL*dqslahsacqGGWPJLQILNLSQNSLSDLkmtGKSLSHLRNLILLDISQNNFGEIPDTCQWPGNLKHLNLSTSQIPK 215
Cdd:COG4886  107 EEL----------SNLTNLESLDLSGNQLTDL---PEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTD 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351430 216 LTTCI-PLT-LEVLDVSANSLKEFGL---QLPFLKELYIAKNQLKTLPDA-APIPSLVAMTIRGNKLNSFskEEFESFKK 289
Cdd:COG4886  174 LPEELgNLTnLKELDLSNNQITDLPEplgNLTNLEELDLSGNQLTDLPEPlANLTNLETLDLSNNQLTDL--PELGNLTN 251

                        250
                 ....*....|.
gi 514351430 290 MEMLDASDNNF 300
Cdd:COG4886  252 LEELDLSNNQL 262
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
154-301 1.23e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 60.10  E-value: 1.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351430 154 LQILNLSQNSLSDLKMTGKSlshlrNLILLDISQNNFGEIPDtcQWPGNLKHLNLSTSQIPKLTTCIPLTLEVLDVSANS 233
Cdd:PRK15370 264 LQSLDLFHNKISCLPENLPE-----ELRYLSVYDNSIRTLPA--HLPSGITHLNVQSNSLTALPETLPPGLKTLEAGENA 336

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 514351430 234 LKEFGLQL-PFLKELYIAKNQLKTLPDAAPiPSLVAMTIRGNKLNSFSKEEFESFKKMEmldASDNNFI 301
Cdd:PRK15370 337 LTSLPASLpPELQVLDVSKNQITVLPETLP-PTITTLDVSRNALTNLPENLPAALQIMQ---ASRNNLV 401
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
104-298 6.00e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 54.70  E-value: 6.00e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351430 104 TKVTVKDTKVFLVPCRLSQRLLSL-----EYLDLSENLl*dqslahsacQGGwpjLQILNLSQNSLSDLKMTgkslshLR 178
Cdd:PRK15370 181 TELRLKILGLTTIPACIPEQITTLildnnELKSLPENL-----------QGN---IKTLYANSNQLTSIPAT------LP 240

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351430 179 NLI-LLDISQNNFGEIPDtcQWPGNLKHLNLSTSQIPKLTTCIPLTLEVLDVSANSLKEFGLQLPF-LKELYIAKNQLKT 256
Cdd:PRK15370 241 DTIqEMELSINRITELPE--RLPSALQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTLPAHLPSgITHLNVQSNSLTA 318

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 514351430 257 LPDAAPiPSLVAMTIRGNKLNSFSkeefESF-KKMEMLDASDN 298
Cdd:PRK15370 319 LPETLP-PGLKTLEAGENALTSLP----ASLpPELQVLDVSKN 356
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
158-262 2.61e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 52.78  E-value: 2.61e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351430 158 NLSQNSLSDLKMTGKSLSHLRNLILLDISQNNFGEIPDTCQwpGNLKHLNLSTSQIPKLTTCIPLTLEVLDVSANSLKEF 237
Cdd:PRK15370 179 NKTELRLKILGLTTIPACIPEQITTLILDNNELKSLPENLQ--GNIKTLYANSNQLTSIPATLPDTIQEMELSINRITEL 256

                         90       100
                 ....*....|....*....|....*.
gi 514351430 238 GLQLP-FLKELYIAKNQLKTLPDAAP 262
Cdd:PRK15370 257 PERLPsALQSLDLFHNKISCLPENLP 282
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 122-209 2.95e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.94  E-value: 2.95e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351430 122 QRLLSLEYLDLSENLL*dQSLAHSacqggwpjLQILNLSQNSLSDLKmtgkSLSHLRNLILLDISQNNFGEIPDTCQ--- 198
Cdd:cd21340  100 QRLPPGEKLTFDPRSL--AALSNS--------LRVLNISGNNIDSLE----PLAPLRNLEQLDASNNQISDLEELLDlls 165

                         90
                 ....*....|..
gi 514351430 199 -WPgNLKHLNLS 209
Cdd:cd21340  166 sWP-SLRELDLT 176
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
120-262 5.88e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 51.62  E-value: 5.88e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351430 120 LSQRLLS-LEYLDLSENLL*dqSLAHSACQGgwpjLQILNLSQNSLS-----------DLKMTGKSLSHL-----RNLIL 182
Cdd:PRK15370 256 LPERLPSaLQSLDLFHNKIS--CLPENLPEE----LRYLSVYDNSIRtlpahlpsgitHLNVQSNSLTALpetlpPGLKT 329

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351430 183 LDISQNNFGEIPDTCqwPGNLKHLNLSTSQIPKLTTCIPLTLEVLDVSANSLKEFGLQLP-FLKELYIAKNQLKTLPDAA 261
Cdd:PRK15370 330 LEAGENALTSLPASL--PPELQVLDVSKNQITVLPETLPPTITTLDVSRNALTNLPENLPaALQIMQASRNNLVRLPESL 407


                 .
gi 514351430 262 P 262
Cdd:PRK15370 408 P 408
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 152-300 6.39e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.77  E-value: 6.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351430 152 PJLQILNLSQNSLSDlkMTGKSLSHLRNLILLDISQNNF-GEIPDTCQWPGNLKHL----NLSTSQIPK-LTTC------ 219
Cdd:PLN00113 332 PRLQVLQLWSNKFSG--EIPKNLGKHNNLTVLDLSTNNLtGEIPEGLCSSGNLFKLilfsNSLEGEIPKsLGACrslrrv 409

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351430 220 -----------------IPLtLEVLDVSANSLK----EFGLQLPFLKELYIAKNQ-LKTLPD------------------ 259
Cdd:PLN00113 410 rlqdnsfsgelpseftkLPL-VYFLDISNNNLQgrinSRKWDMPSLQMLSLARNKfFGGLPDsfgskrlenldlsrnqfs 488

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 514351430 260 -AAP-----IPSLVAMTIRGNKLNSFSKEEFESFKKMEMLDASDNNF 300
Cdd:PLN00113 489 gAVPrklgsLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQL 535
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 103-277 2.16e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 48.89  E-value: 2.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351430 103 LTKVTVKDTKVFLVPCRLSQRLL---SLEYLDLSENLL*DQSLAHSAC--QGGWPJLQILNLSQNSLSDLKMT--GKSLS 175
Cdd:cd00116   83 LQELDLSDNALGPDGCGVLESLLrssSLQELKLNNNGLGDRGLRLLAKglKDLPPALEKLVLGRNRLEGASCEalAKALR 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351430 176 HLRNLILLDISQNNFGE--IPDTCQ---WPGNLKHLNLSTSQI-----PKLTTCIP--LTLEVLDVSANSLKEFGLQ--- 240
Cdd:cd00116  163 ANRDLKELNLANNGIGDagIRALAEglkANCNLEVLDLNNNGLtdegaSALAETLAslKSLEVLNLGDNNLTDAGAAala 242

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 514351430 241 ------LPFLKELYIAKNQL-----KTLPDAAP-IPSLVAMTIRGNKLN 277
Cdd:cd00116  243 sallspNISLLTLSLSCNDItddgaKDLAEVLAeKESLLELDLRGNKFG 291
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 123-300 1.19e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.54  E-value: 1.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351430 123 RLLSLEYLDLSENLL*DQ---SLahsacqGGWPJLQILNLSQNSLSDlkMTGKSLSHLRNLILLDISQNNF-GEIPDTCQ 198
Cdd:PLN00113 234 GLTSLNHLDLVYNNLTGPipsSL------GNLKNLQYLFLYQNKLSG--PIPPSIFSLQKLISLDLSDNSLsGEIPELVI 305

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351430 199 WPGNLKHLNLS----TSQIP-----------------KLTTCIPL------TLEVLDVSANSLKEfglQLP-------FL 244
Cdd:PLN00113 306 QLQNLEILHLFsnnfTGKIPvaltslprlqvlqlwsnKFSGEIPKnlgkhnNLTVLDLSTNNLTG---EIPeglcssgNL 382

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 514351430 245 KELYIAKNQLktlpDAAPIPSLVA-MTIRGNKL--NSFSKEEFESFKKMEM---LDASDNNF 300
Cdd:PLN00113 383 FKLILFSNSL----EGEIPKSLGAcRSLRRVRLqdNSFSGELPSEFTKLPLvyfLDISNNNL 440
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
127-299 1.69e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 46.47  E-value: 1.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351430 127 LEYLDLSENLL*DQSLAHSACQGGWPJLQILNLSQNSLSDLKMTGKSLSHLRNLILLDISQNNFGEIPDTCQWPGNLKHL 206
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351430 207 NLSTSQIPKLTTCIPLTLEVLDVSANSLKEfglQLPFLKELYIAKNQLKTLPDA-APIPSLVAMTIRGNKLNSFSkEEFE 285
Cdd:COG4886   81 LLSLLLLGLTDLGDLTNLTELDLSGNEELS---NLTNLESLDLSGNQLTDLPEElANLTNLKELDLSNNQLTDLP-EPLG 156

                        170
                 ....*....|....
gi 514351430 286 SFKKMEMLDASDNN 299
Cdd:COG4886  157 NLTNLKSLDLSNNQ 170
LRR_8 pfam13855
Leucine rich repeat;
126-190 3.22e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 3.22e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 514351430  126 SLEYLDLSENLL*dQSLAHSACQGgWPJLQILNLSQNSLSDLkmTGKSLSHLRNLILLDISQNNF 190
Cdd:pfam13855   2 NLRSLDLSNNRL--TSLDDGAFKG-LSNLKVLDLSNNLLTTL--SPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 163-300 5.09e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.01  E-value: 5.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351430 163 SLSDLKMTGKS------LSHLRNLILLDISQNNFGEIP--DTCQwpgNLKHLNLSTSQIPKLTTCIPLT-LEVLDVSANS 233
Cdd:cd21340    3 RITHLYLNDKNitkidnLSLCKNLKVLYLYDNKITKIEnlEFLT---NLTHLYLQNNQIEKIENLENLVnLKKLYLGGNR 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 514351430 234 LKEF-GLQ-LPFLKELYIAKNQL----KTLPDAAPI----PSLVAMTIRGNKLNSFskEEFESFKKMEMLDASDNNF 300
Cdd:cd21340   80 ISVVeGLEnLTNLEELHIENQRLppgeKLTFDPRSLaalsNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQI 154
LRR_8 pfam13855
Leucine rich repeat;
244-300 1.80e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.04  E-value: 1.80e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 514351430  244 LKELYIAKNQLKTLPDAAPI--PSLVAMTIRGNKLNSFSKEEFESFKKMEMLDASDNNF 300
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKglSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRCT smart00082
Leucine rich repeat C-terminal domain;
298-351 2.87e-03

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 35.48  E-value: 2.87e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 514351430   298 NNFICSCEFLSFIHHQagIAQILARWPESYICDSPLAVRGeQVGAVHLSLMECH 351
Cdd:smart00082   1 NPFICDCELRWLLRWL--QANEHLQDPVDLRCASPSSLRG-PLLELLHSEFKCP 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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