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Conserved domains on  [gi|514351446|gb|AGO49904|]
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Toll-like receptor 3, partial [Callaeas wilsoni]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1000136)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN00113 super family cl33413
leucine-rich repeat receptor-like protein kinase; Provisional
 17-351 5.08e-11

leucine-rich repeat receptor-like protein kinase; Provisional


The actual alignment was detected with superfamily member PLN00113:

Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 64.48  E-value: 5.08e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446  17 ISKSTFQGlqgTNLTILNLSQNSLS-VIENDSFQWLSSLQYLNLKLNNirvssrlfyglsslkhlnlinsLTGKIEDFSf 95
Cdd:PLN00113  85 ISSAIFRL---PYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNN----------------------FTGSIPRGS- 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446  96 hwLYHLEYLIMDNNNFPGITANMFTGLNNLKYLSLCNcninlQRITNKTFSSLAN-SSLQVLNLTKTRISTIESGAFSSL 174
Cdd:PLN00113 139 --IPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGG-----NVLVGKIPNSLTNlTSLEFLTLASNQLVGQIPRELGQM 211

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 175 GHLKILHLGLNEISQELTgHEFKGLNNVQDIYLSYNKNLSLKSESFIFVPSLRKLMLRKVGCSNlALSPSPFHpLRNLTV 254
Cdd:PLN00113 212 KSLKWIYLGYNNLSGEIP-YEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSG-PIPPSIFS-LQKLIS 288

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 255 LDISNNNIANIKEDLFDGLDKLDILDLQHNNLArlwkhanpGGPVLFLKGLQNLQILNLKSNGLD-EIPVQVFKGlFQLK 333
Cdd:PLN00113 289 LDLSDNSLSGEIPELVIQLQNLEILHLFSNNFT--------GKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKH-NNLT 359

                        330
                 ....*....|....*....
gi 514351446 334 HLDLGSNNLN-LLPATLFD 351
Cdd:PLN00113 360 VLDLSTNNLTgEIPEGLCS 378
 
Name Accession Description Interval E-value
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 17-351 5.08e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 64.48  E-value: 5.08e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446  17 ISKSTFQGlqgTNLTILNLSQNSLS-VIENDSFQWLSSLQYLNLKLNNirvssrlfyglsslkhlnlinsLTGKIEDFSf 95
Cdd:PLN00113  85 ISSAIFRL---PYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNN----------------------FTGSIPRGS- 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446  96 hwLYHLEYLIMDNNNFPGITANMFTGLNNLKYLSLCNcninlQRITNKTFSSLAN-SSLQVLNLTKTRISTIESGAFSSL 174
Cdd:PLN00113 139 --IPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGG-----NVLVGKIPNSLTNlTSLEFLTLASNQLVGQIPRELGQM 211

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 175 GHLKILHLGLNEISQELTgHEFKGLNNVQDIYLSYNKNLSLKSESFIFVPSLRKLMLRKVGCSNlALSPSPFHpLRNLTV 254
Cdd:PLN00113 212 KSLKWIYLGYNNLSGEIP-YEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSG-PIPPSIFS-LQKLIS 288

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 255 LDISNNNIANIKEDLFDGLDKLDILDLQHNNLArlwkhanpGGPVLFLKGLQNLQILNLKSNGLD-EIPVQVFKGlFQLK 333
Cdd:PLN00113 289 LDLSDNSLSGEIPELVIQLQNLEILHLFSNNFT--------GKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKH-NNLT 359

                        330
                 ....*....|....*....
gi 514351446 334 HLDLGSNNLN-LLPATLFD 351
Cdd:PLN00113 360 VLDLSTNNLTgEIPEGLCS 378
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 136-284 6.10e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 58.64  E-value: 6.10e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 136 NLQRITNktFSSLANssLQVLNLTKTRISTIESgaFSSLGHLKILHLGLNEISqELTGHEfkGLNNVQDIYLSYNKnlSL 215
Cdd:cd21340   35 KITKIEN--LEFLTN--LTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRIS-VVEGLE--NLTNLEELHIENQR--LP 103

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 514351446 216 KSESFIFVP-SLRKLM--LRKVGCSNLAL-SPSPFHPLRNLTVLDISNNNIANIKE--DLFDGLDKLDILDLQHN 284
Cdd:cd21340  104 PGEKLTFDPrSLAALSnsLRVLNISGNNIdSLEPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
73-374 4.51e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 57.64  E-value: 4.51e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446  73 GLSSLKHLNLINSLTGKIEDFSFHWLYHLEYLIMDNNNFPGITANMFTGLNNLKYLSLCNCNINLQRITNKTFSSLANSS 152
Cdd:COG4886   10 LKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 153 LQVLNLTK-TRISTIESGAFSSLGHLKILHLGLNEISQelTGHEFKGLNNVQDIYLSYNkNLSLKSESFIFVPSLRKLML 231
Cdd:COG4886   90 TDLGDLTNlTELDLSGNEELSNLTNLESLDLSGNQLTD--LPEELANLTNLKELDLSNN-QLTDLPEPLGNLTNLKSLDL 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 232 RKVGCSNLalsPSPFHPLRNLTVLDISNNNIANIKEDLFdGLDKLDILDLQHNNLARLwkhanpggpVLFLKGLQNLQIL 311
Cdd:COG4886  167 SNNQLTDL---PEELGNLTNLKELDLSNNQITDLPEPLG-NLTNLEELDLSGNQLTDL---------PEPLANLTNLETL 233

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 514351446 312 NLKSNGLDEIPvqVFKGLFQLKHLDLGSNNLNLLPATLfdDQASLNSLNLQKNLITSVEEKVF 374
Cdd:COG4886  234 DLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKEL 292
LRR_8 pfam13855
Leucine rich repeat;
28-82 2.09e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.52  E-value: 2.09e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 514351446   28 TNLTILNLSQNSLSVIENDSFQWLSSLQYLNLKLNNIR-VSSRLFYGLSSLKHLNL 82
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTtLSPGAFSGLPSLRYLDL 56
 
Name Accession Description Interval E-value
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 17-351 5.08e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 64.48  E-value: 5.08e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446  17 ISKSTFQGlqgTNLTILNLSQNSLS-VIENDSFQWLSSLQYLNLKLNNirvssrlfyglsslkhlnlinsLTGKIEDFSf 95
Cdd:PLN00113  85 ISSAIFRL---PYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNN----------------------FTGSIPRGS- 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446  96 hwLYHLEYLIMDNNNFPGITANMFTGLNNLKYLSLCNcninlQRITNKTFSSLAN-SSLQVLNLTKTRISTIESGAFSSL 174
Cdd:PLN00113 139 --IPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGG-----NVLVGKIPNSLTNlTSLEFLTLASNQLVGQIPRELGQM 211

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 175 GHLKILHLGLNEISQELTgHEFKGLNNVQDIYLSYNKNLSLKSESFIFVPSLRKLMLRKVGCSNlALSPSPFHpLRNLTV 254
Cdd:PLN00113 212 KSLKWIYLGYNNLSGEIP-YEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSG-PIPPSIFS-LQKLIS 288

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 255 LDISNNNIANIKEDLFDGLDKLDILDLQHNNLArlwkhanpGGPVLFLKGLQNLQILNLKSNGLD-EIPVQVFKGlFQLK 333
Cdd:PLN00113 289 LDLSDNSLSGEIPELVIQLQNLEILHLFSNNFT--------GKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKH-NNLT 359

                        330
                 ....*....|....*....
gi 514351446 334 HLDLGSNNLN-LLPATLFD 351
Cdd:PLN00113 360 VLDLSTNNLTgEIPEGLCS 378
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 136-284 6.10e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 58.64  E-value: 6.10e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 136 NLQRITNktFSSLANssLQVLNLTKTRISTIESgaFSSLGHLKILHLGLNEISqELTGHEfkGLNNVQDIYLSYNKnlSL 215
Cdd:cd21340   35 KITKIEN--LEFLTN--LTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRIS-VVEGLE--NLTNLEELHIENQR--LP 103

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 514351446 216 KSESFIFVP-SLRKLM--LRKVGCSNLAL-SPSPFHPLRNLTVLDISNNNIANIKE--DLFDGLDKLDILDLQHN 284
Cdd:cd21340  104 PGEKLTFDPrSLAALSnsLRVLNISGNNIdSLEPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
73-374 4.51e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 57.64  E-value: 4.51e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446  73 GLSSLKHLNLINSLTGKIEDFSFHWLYHLEYLIMDNNNFPGITANMFTGLNNLKYLSLCNCNINLQRITNKTFSSLANSS 152
Cdd:COG4886   10 LKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 153 LQVLNLTK-TRISTIESGAFSSLGHLKILHLGLNEISQelTGHEFKGLNNVQDIYLSYNkNLSLKSESFIFVPSLRKLML 231
Cdd:COG4886   90 TDLGDLTNlTELDLSGNEELSNLTNLESLDLSGNQLTD--LPEELANLTNLKELDLSNN-QLTDLPEPLGNLTNLKSLDL 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 232 RKVGCSNLalsPSPFHPLRNLTVLDISNNNIANIKEDLFdGLDKLDILDLQHNNLARLwkhanpggpVLFLKGLQNLQIL 311
Cdd:COG4886  167 SNNQLTDL---PEELGNLTNLKELDLSNNQITDLPEPLG-NLTNLEELDLSGNQLTDL---------PEPLANLTNLETL 233

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 514351446 312 NLKSNGLDEIPvqVFKGLFQLKHLDLGSNNLNLLPATLfdDQASLNSLNLQKNLITSVEEKVF 374
Cdd:COG4886  234 DLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKEL 292
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
28-371 5.19e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 54.17  E-value: 5.19e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446  28 TNLTILNLSQNSLSVIENDSFQWLSSLQYLNLKLNNIRVSSRLFYGLSSLKHLNLINSLTGKIEDFSFHWLYHLEYLIMD 107
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 108 NNNFPGITANMFTGLNNLKYLSLCNcninlqritNKTFSSLANssLQVLNLTKTRISTIESgAFSSLGHLKILHLGLNEI 187
Cdd:COG4886   81 LLSLLLLGLTDLGDLTNLTELDLSG---------NEELSNLTN--LESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQL 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 188 SQelTGHEFKGLNNVQDIYLSYNKnLSLKSESFIFVPSLRKLMLRKVGCSNLalsPSPFHPLRNLTVLDISNNNIANIKE 267
Cdd:COG4886  149 TD--LPEPLGNLTNLKSLDLSNNQ-LTDLPEELGNLTNLKELDLSNNQITDL---PEPLGNLTNLEELDLSGNQLTDLPE 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 268 DLfDGLDKLDILDLQHNNLARLwkhanpggpvLFLKGLQNLQILNLKSNGLDEIPvqVFKGLFQLKHLDLGSNNLNLLPA 347
Cdd:COG4886  223 PL-ANLTNLETLDLSNNQLTDL----------PELGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLTDLKL 289

                        330       340
                 ....*....|....*....|....
gi 514351446 348 TLFDDQASLNSLNLQKNLITSVEE 371
Cdd:COG4886  290 KELELLLGLNSLLLLLLLLNLLEL 313
LRR_8 pfam13855
Leucine rich repeat;
28-82 2.09e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.52  E-value: 2.09e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 514351446   28 TNLTILNLSQNSLSVIENDSFQWLSSLQYLNLKLNNIR-VSSRLFYGLSSLKHLNL 82
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTtLSPGAFSGLPSLRYLDL 56
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 15-147 3.38e-07

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 48.70  E-value: 3.38e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446   15 SYISKSTFQGlqgTNLTILNLSqNSLSVIENDSFQWLSSLQYLNLKLNNIRVSSRLFYGlSSLKHLNLINSLTgKIEDFS 94
Cdd:pfam13306   1 TSIGSYAFYN---CSLTSITIP-SSLTSIGEYAFSNCTSLKSITLPSSLTSIGSYAFYN-CSLTSITIPSSLT-SIGEYA 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 514351446   95 FHWLYHLEYLIMdNNNFPGITANMFTGlNNLKYLSLCNcniNLQRITNKTFSS 147
Cdd:pfam13306  75 FSNCSNLKSITL-PSNLTSIGSYAFSN-CSLKSITIPS---SVTTIGSYAFSN 122
LRR_8 pfam13855
Leucine rich repeat;
307-366 9.66e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 9.66e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446  307 NLQILNLKSNGLDEIPVQVFKGLFQLKHLDLGSNNLNLLPATLFDDQASLNSLNLQKNLI 366
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
5-64 1.96e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.82  E-value: 1.96e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446    5 RNLSLSHVKLSYISKSTFQGLQgtNLTILNLSQNSLSVIENDSFQWLSSLQYLNLKLNNI 64
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLS--NLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 85-367 2.63e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.46  E-value: 2.63e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446  85 SLTGKIEDFSFHWLYhLEYLIMDNNNFPG-ITANMFTGLNNLKYLSLCNCNInlqritNKTFSSLANSSLQVLNLTKTRI 163
Cdd:PLN00113  80 NISGKISSAIFRLPY-IQTINLSNNQLSGpIPDDIFTTSSSLRYLNLSNNNF------TGSIPRGSIPNLETLDLSNNML 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 164 S---TIESGAFSSlghLKILHLGLNEI--------------------SQELTG---HEFKGLNNVQDIYLSYNkNLSlkS 217
Cdd:PLN00113 153 SgeiPNDIGSFSS---LKVLDLGGNVLvgkipnsltnltslefltlaSNQLVGqipRELGQMKSLKWIYLGYN-NLS--G 226

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 218 ESFIFVPSLRKLMLRKVGCSNLALS-PSPFHPLRNLTVLDISNNNIAN-IKEDLFdGLDKLDILDLQHNNLARLWkhanp 295
Cdd:PLN00113 227 EIPYEIGGLTSLNHLDLVYNNLTGPiPSSLGNLKNLQYLFLYQNKLSGpIPPSIF-SLQKLISLDLSDNSLSGEI----- 300

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 514351446 296 ggPVLFLKgLQNLQILNLKSNGLD-EIPVQVfKGLFQLKHLDLGSNNLN-LLPATLfDDQASLNSLNLQKNLIT 367
Cdd:PLN00113 301 --PELVIQ-LQNLEILHLFSNNFTgKIPVAL-TSLPRLQVLQLWSNKFSgEIPKNL-GKHNNLTVLDLSTNNLT 369
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 28-369 2.92e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.46  E-value: 2.92e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446  28 TNLTILNLSQNSLSVIENDSFQWLSSLQYLNLKLNNIrvSSRLFY---GLSSLKHLNLI-NSLTGKIEDfSFHWLYHLEY 103
Cdd:PLN00113 188 TSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNL--SGEIPYeigGLTSLNHLDLVyNNLTGPIPS-SLGNLKNLQY 264

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 104 LIMDNNNFPGITANMFTGLNNLKYLSLCNCNINLQriTNKTFSSLANssLQVLNLTKTRISTIESGAFSSLGHLKILHLG 183
Cdd:PLN00113 265 LFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGE--IPELVIQLQN--LEILHLFSNNFTGKIPVALTSLPRLQVLQLW 340

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 184 LNEISQELTGHEFKGlNNVQDIYLSYNkNLSLK-SESFIFVPSLRKLMLrkVGCSNLALSPSPFHPLRNLTVLDISNNNI 262
Cdd:PLN00113 341 SNKFSGEIPKNLGKH-NNLTVLDLSTN-NLTGEiPEGLCSSGNLFKLIL--FSNSLEGEIPKSLGACRSLRRVRLQDNSF 416

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 263 ANIKEDLFDGLDKLDILDLQHNNL-----ARLWKhanpggpvlflkgLQNLQILNLKSNG-LDEIPVqvFKGLFQLKHLD 336
Cdd:PLN00113 417 SGELPSEFTKLPLVYFLDISNNNLqgrinSRKWD-------------MPSLQMLSLARNKfFGGLPD--SFGSKRLENLD 481

                        330       340       350
                 ....*....|....*....|....*....|...
gi 514351446 337 LGSNNLNLLPATLFDDQASLNSLNLQKNLITSV 369
Cdd:PLN00113 482 LSRNQFSGAVPRKLGSLSELMQLKLSENKLSGE 514
LRR_8 pfam13855
Leucine rich repeat;
224-286 3.07e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.05  E-value: 3.07e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 514351446  224 PSLRKLMLRkvgCSNL-ALSPSPFHPLRNLTVLDISNNNIANIKEDLFDGLDKLDILDLQHNNL 286
Cdd:pfam13855   1 PNLRSLDLS---NNRLtSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
2-289 3.98e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 48.39  E-value: 3.98e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446   2 TAIRNLSLSHVKLSYISKSTFQGlqgTNLTILNLSQNSLSVIeNDSFQWLSSLQYLNLKLNNIRVSSRLFYGLSSLKHLN 81
Cdd:COG4886  113 TNLESLDLSGNQLTDLPEELANL---TNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELD 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446  82 LINSltgKIEDF--SFHWLYHLEYLIMDNNNFPGITANmFTGLNNLKYLSLCNCNInlqritnKTFSSLAN-SSLQVLNL 158
Cdd:COG4886  189 LSNN---QITDLpePLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQL-------TDLPELGNlTNLEELDL 257

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 159 TKTRISTIESGAfsSLGHLKILHLGLNEISQ-ELTGHEFKGLNNVQDIYLSYNKNLSLKSESFIFVPSLRKLMLRKVGCS 237
Cdd:COG4886  258 SNNQLTDLPPLA--NLTNLKTLDLSNNQLTDlKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLV 335

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 514351446 238 NLALSPSPFHPLRNLTVLDISNNNIANIKEDLFDGLDKLDILDLQHNNLARL 289
Cdd:COG4886  336 TLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLL 387
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 246-368 4.07e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.47  E-value: 4.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 246 FHPLRNLTVLDISNNNIANIkEDLfDGLDKLDILDLQHNNLArlwkhanPGGPVLF----LKGLQN-LQILNLKSNGLDE 320
Cdd:cd21340   64 LENLVNLKKLYLGGNRISVV-EGL-ENLTNLEELHIENQRLP-------PGEKLTFdprsLAALSNsLRVLNISGNNIDS 134

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 514351446 321 IpvQVFKGLFQLKHLDLGSNNLNLLPAT--LFDDQASLNSLNLQKNLITS 368
Cdd:cd21340  135 L--EPLAPLRNLEQLDASNNQISDLEELldLLSSWPSLRELDLTGNPVCK 182
LRR_8 pfam13855
Leucine rich repeat;
151-211 5.12e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.67  E-value: 5.12e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 514351446  151 SSLQVLNLTKTRISTIESGAFSSLGHLKILHLGLNEISQeLTGHEFKGLNNVQDIYLSYNK 211
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT-LSPGAFSGLPSLRYLDLSGNR 60
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 153-367 3.45e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.04  E-value: 3.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 153 LQVLNLTKTRISTIE-SGAFSSLGH---LKILHLGLNEISQELTG-----HEFKGLNNVQDIYLSYNKNLSLKS---ESF 220
Cdd:cd00116   25 LQVLRLEGNTLGEEAaKALASALRPqpsLKELCLSLNETGRIPRGlqsllQGLTKGCGLQELDLSDNALGPDGCgvlESL 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 221 IFVPSLRKLMLRKVGCSNLA---LSPSPFHPLRNLTVLDISNNNIANIK-EDL---FDGLDKLDILDLQHNNLArlwkha 293
Cdd:cd00116  105 LRSSSLQELKLNNNGLGDRGlrlLAKGLKDLPPALEKLVLGRNRLEGAScEALakaLRANRDLKELNLANNGIG------ 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 294 NPGGPVLF--LKGLQNLQILNLKSNGLDEIPVQ----VFKGLFQLKHLDLGSNNLNLLPATLFDDQ-----ASLNSLNLQ 362
Cdd:cd00116  179 DAGIRALAegLKANCNLEVLDLNNNGLTDEGASalaeTLASLKSLEVLNLGDNNLTDAGAAALASAllspnISLLTLSLS 258


                 ....*
gi 514351446 363 KNLIT 367
Cdd:cd00116  259 CNDIT 263
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
39-366 4.17e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 45.31  E-value: 4.17e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446  39 SLSVIENDSFQWLSSLQYLNLKLNNIRVSSRLFYGLSSLKHLNL----INSLTGKIEDFSfhwlyHLEYLIMDNNNFPGI 114
Cdd:COG4886  100 ELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLsnnqLTDLPEPLGNLT-----NLKSLDLSNNQLTDL 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 115 TANmFTGLNNLKYLSLCNCNINlqrITNKTFSSLANssLQVLNLTKTRISTIeSGAFSSLGHLKILHLGLNEISQEltgH 194
Cdd:COG4886  175 PEE-LGNLTNLKELDLSNNQIT---DLPEPLGNLTN--LEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDL---P 244

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 195 EFKGLNNVQDIYLSYNKNLSLKSESFIfvPSLRKLMLRKVGCSNLALSPSPFHPLRNLTVLDISNNNIANIKEDLFDGLD 274
Cdd:COG4886  245 ELGNLTNLEELDLSNNQLTDLPPLANL--TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTT 322

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 275 KLDILDLQHNNLARLWKHANPGGPVLFLKGLQNLQILNLKSNGLDEIPVQVFKGLFQLKHLDLGSNNLNLLPATLFDDQA 354
Cdd:COG4886  323 LLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLL 402

                        330
                 ....*....|..
gi 514351446 355 SLNSLNLQKNLI 366
Cdd:COG4886  403 LTLALLDAVNTE 414
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-366 7.40e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 44.54  E-value: 7.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446   1 NTAIRNLSLSHVKLSYISKSTFQGLQGTNLTILNLSQNSLSVIENDSFQWLSSLQYLNLKLNNirvssrLFYGLSSLKHL 80
Cdd:COG4886   45 LLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESL 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446  81 NLINSLTGKIEDfSFHWLYHLEYLIMDNNNFPGITANmFTGLNNLKYLSLCNCninlqRITNKTFSSLANSSLQVLNLTK 160
Cdd:COG4886  119 DLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNN-----QLTDLPEELGNLTNLKELDLSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 161 TRISTIeSGAFSSLGHLKILHLGLNEISQEltGHEFKGLNNVQDIYLSYNKNLSLksESFIFVPSLRKLMLRkvgcSNLA 240
Cdd:COG4886  192 NQITDL-PEPLGNLTNLEELDLSGNQLTDL--PEPLANLTNLETLDLSNNQLTDL--PELGNLTNLEELDLS----NNQL 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 241 LSPSPFHPLRNLTVLDISNNNIANIKEDLFDGLDKLDILDLQHNNLARLWKHANPGGPVLFLKGLQNLQILNLKSNGLDE 320
Cdd:COG4886  263 TDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLAL 342

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 514351446 321 IPVQVFKGLFQLKHLDLGSNNLNLLPATLFDDQASLNSLNLQKNLI 366
Cdd:COG4886  343 SLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLT 388
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 246-371 1.36e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.85  E-value: 1.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 246 FHPLRNLTVLDISNNNIANIKEdlFDGLDKLDILDLQHNNLARLwkhanpggpvLFLKGLQNLQILNLKSN------GLD 319
Cdd:cd21340   20 LSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI----------ENLENLVNLKKLYLGGNrisvveGLE 87

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 514351446 320 eipvqvfkGLFQLKHLDLGSNNLNLLPATLFDDQA------SLNSLNLQKNLITSVEE 371
Cdd:cd21340   88 --------NLTNLEELHIENQRLPPGEKLTFDPRSlaalsnSLRVLNISGNNIDSLEP 137
LRR_8 pfam13855
Leucine rich repeat;
75-135 2.74e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.66  E-value: 2.74e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 514351446   75 SSLKHLNLINSLTGKIEDFSFHWLYHLEYLIMDNNNFPGITANMFTGLNNLKYLSLCNCNI 135
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
275-342 3.40e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.27  E-value: 3.40e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 514351446  275 KLDILDLQHNNLARLWKHAnpggpvlfLKGLQNLQILNLKSNGLDEIPVQVFKGLFQLKHLDLGSNNL 342
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGA--------FKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
124-187 9.37e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 9.37e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 514351446  124 NLKYLSLCNCNInlQRITNKTFSSLanSSLQVLNLTKTRISTIESGAFSSLGHLKILHLGLNEI 187
Cdd:pfam13855   2 NLRSLDLSNNRL--TSLDDGAFKGL--SNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 28-286 1.42e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.60  E-value: 1.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446  28 TNLTILNLSQNSLSVIENDSFQWLSSLQYLNLKLNNIRVS-SRLFYGLSSLKHLNLI-NSLTGKIEDFSFHwLYHLEYLI 105
Cdd:PLN00113 236 TSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPiPPSIFSLQKLISLDLSdNSLSGEIPELVIQ-LQNLEILH 314

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 106 MDNNNFPGITANMFTGLNNLKYLSLCNCNI------NLQRITNKTFSSLANSSL---------QVLNLTKTRI--STIES 168
Cdd:PLN00113 315 LFSNNFTGKIPVALTSLPRLQVLQLWSNKFsgeipkNLGKHNNLTVLDLSTNNLtgeipeglcSSGNLFKLILfsNSLEG 394

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 169 GAFSSLG---HLKILHLGLNEISQELTgHEFKGLNNVQDIYLSYNkNLSLKSESFIF-VPSLRKLML------------- 231
Cdd:PLN00113 395 EIPKSLGacrSLRRVRLQDNSFSGELP-SEFTKLPLVYFLDISNN-NLQGRINSRKWdMPSLQMLSLarnkffgglpdsf 472

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 514351446 232 RKVGCSNLALS--------PSPFHPLRNLTVLDISNNNIANIKEDLFDGLDKLDILDLQHNNL 286
Cdd:PLN00113 473 GSKRLENLDLSrnqfsgavPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQL 535
LRR_8 pfam13855
Leucine rich repeat;
52-111 6.03e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 34.81  E-value: 6.03e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 514351446   52 SSLQYLNLKLNNI-RVSSRLFYGLSSLKHLNLINSLTGKIEDFSFHWLYHLEYLIMDNNNF 111
Cdd:pfam13855   1 PNLRSLDLSNNRLtSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 2-130 9.34e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 37.07  E-value: 9.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446   2 TAIRNLS----LSHVKLS--YISKstFQGLQG-TNLTILNLSQNSLSVIENdsFQWLSSLQYLNLKLNNIRVSSRLF--- 71
Cdd:cd21340   37 TKIENLEfltnLTHLYLQnnQIEK--IENLENlVNLKKLYLGGNRISVVEG--LENLTNLEELHIENQRLPPGEKLTfdp 112

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 514351446  72 ---YGLS-SLKHLNLINSLTGKIEDFSFhwLYHLEYLIMDNNNFPGIT--ANMFTGLNNLKYLSL 130
Cdd:cd21340  113 rslAALSnSLRVLNISGNNIDSLEPLAP--LRNLEQLDASNNQISDLEelLDLLSSWPSLRELDL 175
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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