|
Name |
Accession |
Description |
Interval |
E-value |
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
17-351 |
5.08e-11 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 64.48 E-value: 5.08e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 17 ISKSTFQGlqgTNLTILNLSQNSLS-VIENDSFQWLSSLQYLNLKLNNirvssrlfyglsslkhlnlinsLTGKIEDFSf 95
Cdd:PLN00113 85 ISSAIFRL---PYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNN----------------------FTGSIPRGS- 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 96 hwLYHLEYLIMDNNNFPGITANMFTGLNNLKYLSLCNcninlQRITNKTFSSLAN-SSLQVLNLTKTRISTIESGAFSSL 174
Cdd:PLN00113 139 --IPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGG-----NVLVGKIPNSLTNlTSLEFLTLASNQLVGQIPRELGQM 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 175 GHLKILHLGLNEISQELTgHEFKGLNNVQDIYLSYNKNLSLKSESFIFVPSLRKLMLRKVGCSNlALSPSPFHpLRNLTV 254
Cdd:PLN00113 212 KSLKWIYLGYNNLSGEIP-YEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSG-PIPPSIFS-LQKLIS 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 255 LDISNNNIANIKEDLFDGLDKLDILDLQHNNLArlwkhanpGGPVLFLKGLQNLQILNLKSNGLD-EIPVQVFKGlFQLK 333
Cdd:PLN00113 289 LDLSDNSLSGEIPELVIQLQNLEILHLFSNNFT--------GKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKH-NNLT 359
|
330
....*....|....*....
gi 514351446 334 HLDLGSNNLN-LLPATLFD 351
Cdd:PLN00113 360 VLDLSTNNLTgEIPEGLCS 378
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
136-284 |
6.10e-10 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 58.64 E-value: 6.10e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 136 NLQRITNktFSSLANssLQVLNLTKTRISTIESgaFSSLGHLKILHLGLNEISqELTGHEfkGLNNVQDIYLSYNKnlSL 215
Cdd:cd21340 35 KITKIEN--LEFLTN--LTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRIS-VVEGLE--NLTNLEELHIENQR--LP 103
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 514351446 216 KSESFIFVP-SLRKLM--LRKVGCSNLAL-SPSPFHPLRNLTVLDISNNNIANIKE--DLFDGLDKLDILDLQHN 284
Cdd:cd21340 104 PGEKLTFDPrSLAALSnsLRVLNISGNNIdSLEPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
73-374 |
4.51e-09 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 57.64 E-value: 4.51e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 73 GLSSLKHLNLINSLTGKIEDFSFHWLYHLEYLIMDNNNFPGITANMFTGLNNLKYLSLCNCNINLQRITNKTFSSLANSS 152
Cdd:COG4886 10 LKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 153 LQVLNLTK-TRISTIESGAFSSLGHLKILHLGLNEISQelTGHEFKGLNNVQDIYLSYNkNLSLKSESFIFVPSLRKLML 231
Cdd:COG4886 90 TDLGDLTNlTELDLSGNEELSNLTNLESLDLSGNQLTD--LPEELANLTNLKELDLSNN-QLTDLPEPLGNLTNLKSLDL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 232 RKVGCSNLalsPSPFHPLRNLTVLDISNNNIANIKEDLFdGLDKLDILDLQHNNLARLwkhanpggpVLFLKGLQNLQIL 311
Cdd:COG4886 167 SNNQLTDL---PEELGNLTNLKELDLSNNQITDLPEPLG-NLTNLEELDLSGNQLTDL---------PEPLANLTNLETL 233
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 514351446 312 NLKSNGLDEIPvqVFKGLFQLKHLDLGSNNLNLLPATLfdDQASLNSLNLQKNLITSVEEKVF 374
Cdd:COG4886 234 DLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKEL 292
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
28-371 |
5.19e-08 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 54.17 E-value: 5.19e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 28 TNLTILNLSQNSLSVIENDSFQWLSSLQYLNLKLNNIRVSSRLFYGLSSLKHLNLINSLTGKIEDFSFHWLYHLEYLIMD 107
Cdd:COG4886 1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 108 NNNFPGITANMFTGLNNLKYLSLCNcninlqritNKTFSSLANssLQVLNLTKTRISTIESgAFSSLGHLKILHLGLNEI 187
Cdd:COG4886 81 LLSLLLLGLTDLGDLTNLTELDLSG---------NEELSNLTN--LESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQL 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 188 SQelTGHEFKGLNNVQDIYLSYNKnLSLKSESFIFVPSLRKLMLRKVGCSNLalsPSPFHPLRNLTVLDISNNNIANIKE 267
Cdd:COG4886 149 TD--LPEPLGNLTNLKSLDLSNNQ-LTDLPEELGNLTNLKELDLSNNQITDL---PEPLGNLTNLEELDLSGNQLTDLPE 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 268 DLfDGLDKLDILDLQHNNLARLwkhanpggpvLFLKGLQNLQILNLKSNGLDEIPvqVFKGLFQLKHLDLGSNNLNLLPA 347
Cdd:COG4886 223 PL-ANLTNLETLDLSNNQLTDL----------PELGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLTDLKL 289
|
330 340
....*....|....*....|....
gi 514351446 348 TLFDDQASLNSLNLQKNLITSVEE 371
Cdd:COG4886 290 KELELLLGLNSLLLLLLLLNLLEL 313
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
28-82 |
2.09e-07 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 47.52 E-value: 2.09e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 514351446 28 TNLTILNLSQNSLSVIENDSFQWLSSLQYLNLKLNNIR-VSSRLFYGLSSLKHLNL 82
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTtLSPGAFSGLPSLRYLDL 56
|
|
| LRR_5 |
pfam13306 |
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ... |
15-147 |
3.38e-07 |
|
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.
Pssm-ID: 463839 [Multi-domain] Cd Length: 127 Bit Score: 48.70 E-value: 3.38e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 15 SYISKSTFQGlqgTNLTILNLSqNSLSVIENDSFQWLSSLQYLNLKLNNIRVSSRLFYGlSSLKHLNLINSLTgKIEDFS 94
Cdd:pfam13306 1 TSIGSYAFYN---CSLTSITIP-SSLTSIGEYAFSNCTSLKSITLPSSLTSIGSYAFYN-CSLTSITIPSSLT-SIGEYA 74
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 514351446 95 FHWLYHLEYLIMdNNNFPGITANMFTGlNNLKYLSLCNcniNLQRITNKTFSS 147
Cdd:pfam13306 75 FSNCSNLKSITL-PSNLTSIGSYAFSN-CSLKSITIPS---SVTTIGSYAFSN 122
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
307-366 |
9.66e-07 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 45.59 E-value: 9.66e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 307 NLQILNLKSNGLDEIPVQVFKGLFQLKHLDLGSNNLNLLPATLFDDQASLNSLNLQKNLI 366
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
5-64 |
1.96e-06 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 44.82 E-value: 1.96e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 5 RNLSLSHVKLSYISKSTFQGLQgtNLTILNLSQNSLSVIENDSFQWLSSLQYLNLKLNNI 64
Cdd:pfam13855 4 RSLDLSNNRLTSLDDGAFKGLS--NLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
85-367 |
2.63e-06 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 49.46 E-value: 2.63e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 85 SLTGKIEDFSFHWLYhLEYLIMDNNNFPG-ITANMFTGLNNLKYLSLCNCNInlqritNKTFSSLANSSLQVLNLTKTRI 163
Cdd:PLN00113 80 NISGKISSAIFRLPY-IQTINLSNNQLSGpIPDDIFTTSSSLRYLNLSNNNF------TGSIPRGSIPNLETLDLSNNML 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 164 S---TIESGAFSSlghLKILHLGLNEI--------------------SQELTG---HEFKGLNNVQDIYLSYNkNLSlkS 217
Cdd:PLN00113 153 SgeiPNDIGSFSS---LKVLDLGGNVLvgkipnsltnltslefltlaSNQLVGqipRELGQMKSLKWIYLGYN-NLS--G 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 218 ESFIFVPSLRKLMLRKVGCSNLALS-PSPFHPLRNLTVLDISNNNIAN-IKEDLFdGLDKLDILDLQHNNLARLWkhanp 295
Cdd:PLN00113 227 EIPYEIGGLTSLNHLDLVYNNLTGPiPSSLGNLKNLQYLFLYQNKLSGpIPPSIF-SLQKLISLDLSDNSLSGEI----- 300
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 514351446 296 ggPVLFLKgLQNLQILNLKSNGLD-EIPVQVfKGLFQLKHLDLGSNNLN-LLPATLfDDQASLNSLNLQKNLIT 367
Cdd:PLN00113 301 --PELVIQ-LQNLEILHLFSNNFTgKIPVAL-TSLPRLQVLQLWSNKFSgEIPKNL-GKHNNLTVLDLSTNNLT 369
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
28-369 |
2.92e-06 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 49.46 E-value: 2.92e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 28 TNLTILNLSQNSLSVIENDSFQWLSSLQYLNLKLNNIrvSSRLFY---GLSSLKHLNLI-NSLTGKIEDfSFHWLYHLEY 103
Cdd:PLN00113 188 TSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNL--SGEIPYeigGLTSLNHLDLVyNNLTGPIPS-SLGNLKNLQY 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 104 LIMDNNNFPGITANMFTGLNNLKYLSLCNCNINLQriTNKTFSSLANssLQVLNLTKTRISTIESGAFSSLGHLKILHLG 183
Cdd:PLN00113 265 LFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGE--IPELVIQLQN--LEILHLFSNNFTGKIPVALTSLPRLQVLQLW 340
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 184 LNEISQELTGHEFKGlNNVQDIYLSYNkNLSLK-SESFIFVPSLRKLMLrkVGCSNLALSPSPFHPLRNLTVLDISNNNI 262
Cdd:PLN00113 341 SNKFSGEIPKNLGKH-NNLTVLDLSTN-NLTGEiPEGLCSSGNLFKLIL--FSNSLEGEIPKSLGACRSLRRVRLQDNSF 416
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 263 ANIKEDLFDGLDKLDILDLQHNNL-----ARLWKhanpggpvlflkgLQNLQILNLKSNG-LDEIPVqvFKGLFQLKHLD 336
Cdd:PLN00113 417 SGELPSEFTKLPLVYFLDISNNNLqgrinSRKWD-------------MPSLQMLSLARNKfFGGLPD--SFGSKRLENLD 481
|
330 340 350
....*....|....*....|....*....|...
gi 514351446 337 LGSNNLNLLPATLFDDQASLNSLNLQKNLITSV 369
Cdd:PLN00113 482 LSRNQFSGAVPRKLGSLSELMQLKLSENKLSGE 514
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
224-286 |
3.07e-06 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 44.05 E-value: 3.07e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 514351446 224 PSLRKLMLRkvgCSNL-ALSPSPFHPLRNLTVLDISNNNIANIKEDLFDGLDKLDILDLQHNNL 286
Cdd:pfam13855 1 PNLRSLDLS---NNRLtSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
2-289 |
3.98e-06 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 48.39 E-value: 3.98e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 2 TAIRNLSLSHVKLSYISKSTFQGlqgTNLTILNLSQNSLSVIeNDSFQWLSSLQYLNLKLNNIRVSSRLFYGLSSLKHLN 81
Cdd:COG4886 113 TNLESLDLSGNQLTDLPEELANL---TNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELD 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 82 LINSltgKIEDF--SFHWLYHLEYLIMDNNNFPGITANmFTGLNNLKYLSLCNCNInlqritnKTFSSLAN-SSLQVLNL 158
Cdd:COG4886 189 LSNN---QITDLpePLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQL-------TDLPELGNlTNLEELDL 257
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 159 TKTRISTIESGAfsSLGHLKILHLGLNEISQ-ELTGHEFKGLNNVQDIYLSYNKNLSLKSESFIFVPSLRKLMLRKVGCS 237
Cdd:COG4886 258 SNNQLTDLPPLA--NLTNLKTLDLSNNQLTDlKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLV 335
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 514351446 238 NLALSPSPFHPLRNLTVLDISNNNIANIKEDLFDGLDKLDILDLQHNNLARL 289
Cdd:COG4886 336 TLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLL 387
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
246-368 |
4.07e-06 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 47.47 E-value: 4.07e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 246 FHPLRNLTVLDISNNNIANIkEDLfDGLDKLDILDLQHNNLArlwkhanPGGPVLF----LKGLQN-LQILNLKSNGLDE 320
Cdd:cd21340 64 LENLVNLKKLYLGGNRISVV-EGL-ENLTNLEELHIENQRLP-------PGEKLTFdprsLAALSNsLRVLNISGNNIDS 134
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 514351446 321 IpvQVFKGLFQLKHLDLGSNNLNLLPAT--LFDDQASLNSLNLQKNLITS 368
Cdd:cd21340 135 L--EPLAPLRNLEQLDASNNQISDLEELldLLSSWPSLRELDLTGNPVCK 182
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
151-211 |
5.12e-06 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 43.67 E-value: 5.12e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 514351446 151 SSLQVLNLTKTRISTIESGAFSSLGHLKILHLGLNEISQeLTGHEFKGLNNVQDIYLSYNK 211
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT-LSPGAFSGLPSLRYLDLSGNR 60
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
153-367 |
3.45e-05 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 45.04 E-value: 3.45e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 153 LQVLNLTKTRISTIE-SGAFSSLGH---LKILHLGLNEISQELTG-----HEFKGLNNVQDIYLSYNKNLSLKS---ESF 220
Cdd:cd00116 25 LQVLRLEGNTLGEEAaKALASALRPqpsLKELCLSLNETGRIPRGlqsllQGLTKGCGLQELDLSDNALGPDGCgvlESL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 221 IFVPSLRKLMLRKVGCSNLA---LSPSPFHPLRNLTVLDISNNNIANIK-EDL---FDGLDKLDILDLQHNNLArlwkha 293
Cdd:cd00116 105 LRSSSLQELKLNNNGLGDRGlrlLAKGLKDLPPALEKLVLGRNRLEGAScEALakaLRANRDLKELNLANNGIG------ 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 294 NPGGPVLF--LKGLQNLQILNLKSNGLDEIPVQ----VFKGLFQLKHLDLGSNNLNLLPATLFDDQ-----ASLNSLNLQ 362
Cdd:cd00116 179 DAGIRALAegLKANCNLEVLDLNNNGLTDEGASalaeTLASLKSLEVLNLGDNNLTDAGAAALASAllspnISLLTLSLS 258
|
....*
gi 514351446 363 KNLIT 367
Cdd:cd00116 259 CNDIT 263
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
39-366 |
4.17e-05 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 45.31 E-value: 4.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 39 SLSVIENDSFQWLSSLQYLNLKLNNIRVSSRLFYGLSSLKHLNL----INSLTGKIEDFSfhwlyHLEYLIMDNNNFPGI 114
Cdd:COG4886 100 ELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLsnnqLTDLPEPLGNLT-----NLKSLDLSNNQLTDL 174
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 115 TANmFTGLNNLKYLSLCNCNINlqrITNKTFSSLANssLQVLNLTKTRISTIeSGAFSSLGHLKILHLGLNEISQEltgH 194
Cdd:COG4886 175 PEE-LGNLTNLKELDLSNNQIT---DLPEPLGNLTN--LEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDL---P 244
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 195 EFKGLNNVQDIYLSYNKNLSLKSESFIfvPSLRKLMLRKVGCSNLALSPSPFHPLRNLTVLDISNNNIANIKEDLFDGLD 274
Cdd:COG4886 245 ELGNLTNLEELDLSNNQLTDLPPLANL--TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTT 322
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 275 KLDILDLQHNNLARLWKHANPGGPVLFLKGLQNLQILNLKSNGLDEIPVQVFKGLFQLKHLDLGSNNLNLLPATLFDDQA 354
Cdd:COG4886 323 LLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLL 402
|
330
....*....|..
gi 514351446 355 SLNSLNLQKNLI 366
Cdd:COG4886 403 LTLALLDAVNTE 414
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
1-366 |
7.40e-05 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 44.54 E-value: 7.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 1 NTAIRNLSLSHVKLSYISKSTFQGLQGTNLTILNLSQNSLSVIENDSFQWLSSLQYLNLKLNNirvssrLFYGLSSLKHL 80
Cdd:COG4886 45 LLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESL 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 81 NLINSLTGKIEDfSFHWLYHLEYLIMDNNNFPGITANmFTGLNNLKYLSLCNCninlqRITNKTFSSLANSSLQVLNLTK 160
Cdd:COG4886 119 DLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNN-----QLTDLPEELGNLTNLKELDLSN 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 161 TRISTIeSGAFSSLGHLKILHLGLNEISQEltGHEFKGLNNVQDIYLSYNKNLSLksESFIFVPSLRKLMLRkvgcSNLA 240
Cdd:COG4886 192 NQITDL-PEPLGNLTNLEELDLSGNQLTDL--PEPLANLTNLETLDLSNNQLTDL--PELGNLTNLEELDLS----NNQL 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 241 LSPSPFHPLRNLTVLDISNNNIANIKEDLFDGLDKLDILDLQHNNLARLWKHANPGGPVLFLKGLQNLQILNLKSNGLDE 320
Cdd:COG4886 263 TDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLAL 342
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 514351446 321 IPVQVFKGLFQLKHLDLGSNNLNLLPATLFDDQASLNSLNLQKNLI 366
Cdd:COG4886 343 SLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLT 388
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
246-371 |
1.36e-04 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 42.85 E-value: 1.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 246 FHPLRNLTVLDISNNNIANIKEdlFDGLDKLDILDLQHNNLARLwkhanpggpvLFLKGLQNLQILNLKSN------GLD 319
Cdd:cd21340 20 LSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI----------ENLENLVNLKKLYLGGNrisvveGLE 87
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 514351446 320 eipvqvfkGLFQLKHLDLGSNNLNLLPATLFDDQA------SLNSLNLQKNLITSVEE 371
Cdd:cd21340 88 --------NLTNLEELHIENQRLPPGEKLTFDPRSlaalsnSLRVLNISGNNIDSLEP 137
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
75-135 |
2.74e-04 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 38.66 E-value: 2.74e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 514351446 75 SSLKHLNLINSLTGKIEDFSFHWLYHLEYLIMDNNNFPGITANMFTGLNNLKYLSLCNCNI 135
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
275-342 |
3.40e-04 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 38.27 E-value: 3.40e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 514351446 275 KLDILDLQHNNLARLWKHAnpggpvlfLKGLQNLQILNLKSNGLDEIPVQVFKGLFQLKHLDLGSNNL 342
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGA--------FKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
124-187 |
9.37e-04 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 37.12 E-value: 9.37e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 514351446 124 NLKYLSLCNCNInlQRITNKTFSSLanSSLQVLNLTKTRISTIESGAFSSLGHLKILHLGLNEI 187
Cdd:pfam13855 2 NLRSLDLSNNRL--TSLDDGAFKGL--SNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
28-286 |
1.42e-03 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 40.60 E-value: 1.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 28 TNLTILNLSQNSLSVIENDSFQWLSSLQYLNLKLNNIRVS-SRLFYGLSSLKHLNLI-NSLTGKIEDFSFHwLYHLEYLI 105
Cdd:PLN00113 236 TSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPiPPSIFSLQKLISLDLSdNSLSGEIPELVIQ-LQNLEILH 314
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 106 MDNNNFPGITANMFTGLNNLKYLSLCNCNI------NLQRITNKTFSSLANSSL---------QVLNLTKTRI--STIES 168
Cdd:PLN00113 315 LFSNNFTGKIPVALTSLPRLQVLQLWSNKFsgeipkNLGKHNNLTVLDLSTNNLtgeipeglcSSGNLFKLILfsNSLEG 394
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 169 GAFSSLG---HLKILHLGLNEISQELTgHEFKGLNNVQDIYLSYNkNLSLKSESFIF-VPSLRKLML------------- 231
Cdd:PLN00113 395 EIPKSLGacrSLRRVRLQDNSFSGELP-SEFTKLPLVYFLDISNN-NLQGRINSRKWdMPSLQMLSLarnkffgglpdsf 472
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 514351446 232 RKVGCSNLALS--------PSPFHPLRNLTVLDISNNNIANIKEDLFDGLDKLDILDLQHNNL 286
Cdd:PLN00113 473 GSKRLENLDLSrnqfsgavPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQL 535
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
52-111 |
6.03e-03 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 34.81 E-value: 6.03e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 514351446 52 SSLQYLNLKLNNI-RVSSRLFYGLSSLKHLNLINSLTGKIEDFSFHWLYHLEYLIMDNNNF 111
Cdd:pfam13855 1 PNLRSLDLSNNRLtSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
2-130 |
9.34e-03 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 37.07 E-value: 9.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351446 2 TAIRNLS----LSHVKLS--YISKstFQGLQG-TNLTILNLSQNSLSVIENdsFQWLSSLQYLNLKLNNIRVSSRLF--- 71
Cdd:cd21340 37 TKIENLEfltnLTHLYLQnnQIEK--IENLENlVNLKKLYLGGNRISVVEG--LENLTNLEELHIENQRLPPGEKLTfdp 112
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 514351446 72 ---YGLS-SLKHLNLINSLTGKIEDFSFhwLYHLEYLIMDNNNFPGIT--ANMFTGLNNLKYLSL 130
Cdd:cd21340 113 rslAALSnSLRVLNISGNNIDSLEPLAP--LRNLEQLDASNNQISDLEelLDLLSSWPSLRELDL 175
|
|
|