NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|514351472|gb|AGO49917|]
View 

Toll-like receptor 4, partial [Notiomystis cincta]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
100-256 2.04e-13

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 69.19  E-value: 2.04e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351472 100 IGNVSTIRLVSLGLEKISEVPV----LSKVRQLECKKCHFEDVPAVkLSLFKELRVLRITKNKsLKIFNQKFKGLSNLEV 175
Cdd:COG4886  109 LSNLTNLESLDLSGNQLTDLPEelanLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQ-LTDLPEELGNLTNLKE 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351472 176 LDLSDNRLTFSrccSLQFENCPNLKHLNLSYNSNIKLNGDFTNMKNLLYLDLQHTTVvgpKNFPVFLTLQRLIYLDISYT 255
Cdd:COG4886  187 LDLSNNQITDL---PEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL---TDLPELGNLTNLEELDLSNN 260


                 .
gi 514351472 256 K 256
Cdd:COG4886  261 Q 261
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
100-256 2.04e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 69.19  E-value: 2.04e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351472 100 IGNVSTIRLVSLGLEKISEVPV----LSKVRQLECKKCHFEDVPAVkLSLFKELRVLRITKNKsLKIFNQKFKGLSNLEV 175
Cdd:COG4886  109 LSNLTNLESLDLSGNQLTDLPEelanLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQ-LTDLPEELGNLTNLKE 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351472 176 LDLSDNRLTFSrccSLQFENCPNLKHLNLSYNSNIKLNGDFTNMKNLLYLDLQHTTVvgpKNFPVFLTLQRLIYLDISYT 255
Cdd:COG4886  187 LDLSNNQITDL---PEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL---TDLPELGNLTNLEELDLSNN 260


                 .
gi 514351472 256 K 256
Cdd:COG4886  261 Q 261
LRR_8 pfam13855
Leucine rich repeat;
148-207 5.76e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 5.76e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351472  148 ELRVLRITKNKSLKIFNQKFKGLSNLEVLDLSDNRLTFSRCCSlqFENCPNLKHLNLSYN 207
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGA--FSGLPSLRYLDLSGN 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 142-228 7.32e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.77  E-value: 7.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351472 142 KLSLFKELRVLRITKNKSLKIfnQKFKGLSNLEVLDLSDNRLTfsrccSLQ-FENCPNLKHLNLSYNSNIKLNGdFTNMK 220
Cdd:cd21340   19 NLSLCKNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIE-----KIEnLENLVNLKKLYLGGNRISVVEG-LENLT 90

                         90
                 ....*....|
gi 514351472 221 NL--LYLDLQ 228
Cdd:cd21340   91 NLeeLHIENQ 100
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
100-256 2.04e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 69.19  E-value: 2.04e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351472 100 IGNVSTIRLVSLGLEKISEVPV----LSKVRQLECKKCHFEDVPAVkLSLFKELRVLRITKNKsLKIFNQKFKGLSNLEV 175
Cdd:COG4886  109 LSNLTNLESLDLSGNQLTDLPEelanLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQ-LTDLPEELGNLTNLKE 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351472 176 LDLSDNRLTFSrccSLQFENCPNLKHLNLSYNSNIKLNGDFTNMKNLLYLDLQHTTVvgpKNFPVFLTLQRLIYLDISYT 255
Cdd:COG4886  187 LDLSNNQITDL---PEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL---TDLPELGNLTNLEELDLSNN 260


                 .
gi 514351472 256 K 256
Cdd:COG4886  261 Q 261
LRR_8 pfam13855
Leucine rich repeat;
148-207 5.76e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 5.76e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351472  148 ELRVLRITKNKSLKIFNQKFKGLSNLEVLDLSDNRLTFSRCCSlqFENCPNLKHLNLSYN 207
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGA--FSGLPSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
171-230 5.05e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.90  E-value: 5.05e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 514351472  171 SNLEVLDLSDNRLTFSRccSLQFENCPNLKHLNLSYNS-NIKLNGDFTNMKNLLYLDLQHT 230
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLD--DGAFKGLSNLKVLDLSNNLlTTLSPGAFSGLPSLRYLDLSGN 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 142-228 7.32e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.77  E-value: 7.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351472 142 KLSLFKELRVLRITKNKSLKIfnQKFKGLSNLEVLDLSDNRLTfsrccSLQ-FENCPNLKHLNLSYNSNIKLNGdFTNMK 220
Cdd:cd21340   19 NLSLCKNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIE-----KIEnLENLVNLKKLYLGGNRISVVEG-LENLT 90

                         90
                 ....*....|
gi 514351472 221 NL--LYLDLQ 228
Cdd:cd21340   91 NLeeLHIENQ 100
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
142-256 2.28e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 38.76  E-value: 2.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351472 142 KLSLFKELRVLRITKNKSLKIFNQKFKGLSNLEVLDLSDNRltfsrccslQFENCPNLKHLNLSYNSNIKLNGDFTNMKN 221
Cdd:COG4886   67 LLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE---------ELSNLTNLESLDLSGNQLTDLPEELANLTN 137

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 514351472 222 LLYLDLQHTTVvgpKNFPVFLT-LQRLIYLDISYTK 256
Cdd:COG4886  138 LKELDLSNNQL---TDLPEPLGnLTNLKSLDLSNNQ 170
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 172-211 2.34e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.91  E-value: 2.34e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 514351472  172 NLEVLDLSDNRLTFSRccslQFENCPNLKHLNLSYNSNIK 211
Cdd:pfam12799   2 NLEVLDLSNNQITDIP----PLAKLPNLETLDLSGNNKIT 37
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 143-207 3.99e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 37.46  E-value: 3.99e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 514351472 143 LSLFKELRVLRITKNK--SLkifnQKFKGLSNLEVLDLSDNRLTFSRCCSLQFENCPNLKHLNLSYN 207
Cdd:cd21340  116 AALSNSLRVLNISGNNidSL----EPLAPLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGN 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH