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Conserved domains on  [gi|514351512|gb|AGO49937|]
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Toll-like receptor 7, partial [Callaeas wilsoni]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-227 4.16e-16

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 77.67  E-value: 4.16e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351512   1 LAILSLKSNNLTHIPPNLSS--SLKELYIYNN*IQEIQEqDLSGLHNLEILDLSGNcprcynapypcipcpkssiQIHS- 77
Cdd:COG4886  115 LESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNN-------------------QLTDl 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351512  78 -RAFDSLEKLRILRLHSNSLQSIPSSwFRNIKNLKELDLSQNFLmREIGDAqfLTLIPSLVQLDLSFNfelkvyspflNL 156
Cdd:COG4886  175 pEELGNLTNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQL-TDLPEP--LANLTNLETLDLSNN----------QL 240

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 514351512 157 SK--TFSSLANLETLRLKGyvfkeLRAQDLHPLLSLRNLTMLDLGTNFIKIADLTVFEEFPALKFIDLSVNKI 227
Cdd:COG4886  241 TDlpELGNLTNLEELDLSN-----NQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLL 308
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-227 4.16e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 77.67  E-value: 4.16e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351512   1 LAILSLKSNNLTHIPPNLSS--SLKELYIYNN*IQEIQEqDLSGLHNLEILDLSGNcprcynapypcipcpkssiQIHS- 77
Cdd:COG4886  115 LESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNN-------------------QLTDl 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351512  78 -RAFDSLEKLRILRLHSNSLQSIPSSwFRNIKNLKELDLSQNFLmREIGDAqfLTLIPSLVQLDLSFNfelkvyspflNL 156
Cdd:COG4886  175 pEELGNLTNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQL-TDLPEP--LANLTNLETLDLSNN----------QL 240

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 514351512 157 SK--TFSSLANLETLRLKGyvfkeLRAQDLHPLLSLRNLTMLDLGTNFIKIADLTVFEEFPALKFIDLSVNKI 227
Cdd:COG4886  241 TDlpELGNLTNLEELDLSN-----NQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLL 308
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 1-144 8.87e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 54.41  E-value: 8.87e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351512   1 LAILSLKSNNLTHIPpNLSS--SLKELYIYNN*IQEIQeqDLSGLHNLEILDLSGNCPRC----YNAP--------YPCI 66
Cdd:cd21340   26 LKVLYLYDNKITKIE-NLEFltNLTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNRISVveglENLTnleelhieNQRL 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351512  67 PcPKSSIQIHSRAFDSLEK-LRILRLHSNSLQSIpsSWFRNIKNLKELDLSQNFL--MREIgdAQFLTLIPSLVQLDLSF 143
Cdd:cd21340  103 P-PGEKLTFDPRSLAALSNsLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQIsdLEEL--LDLLSSWPSLRELDLTG 177


                 .
gi 514351512 144 N 144
Cdd:cd21340  178 N 178
LRR_8 pfam13855
Leucine rich repeat;
85-144 1.14e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.90  E-value: 1.14e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351512   85 KLRILRLHSNSLQSIPSSWFRNIKNLKELDLSQNfLMREIGDAQFLTLiPSLVQLDLSFN 144
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNN-LLTTLSPGAFSGL-PSLRYLDLSGN 59
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 1-201 1.20e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 52.54  E-value: 1.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351512   1 LAILSLKSNNLT-HIPPNLSS--SLKELYI-YNN*IQEIQEQdLSGLHNLEILDLsgncprCYNAPYPCIPCpkssiqih 76
Cdd:PLN00113 190 LEFLTLASNQLVgQIPRELGQmkSLKWIYLgYNNLSGEIPYE-IGGLTSLNHLDL------VYNNLTGPIPS-------- 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351512  77 srAFDSLEKLRILRLHSNSLQ-SIPSSWFrNIKNLKELDLSQNFLMREIgdAQFLTLIPSLVQLDL-SFNFELKVyspfl 154
Cdd:PLN00113 255 --SLGNLKNLQYLFLYQNKLSgPIPPSIF-SLQKLISLDLSDNSLSGEI--PELVIQLQNLEILHLfSNNFTGKI----- 324

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 514351512 155 nlSKTFSSLANLETL-----RLKGYVFKELRAQDlhpllslrNLTMLDLGTN 201
Cdd:PLN00113 325 --PVALTSLPRLQVLqlwsnKFSGEIPKNLGKHN--------NLTVLDLSTN 366
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-227 4.16e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 77.67  E-value: 4.16e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351512   1 LAILSLKSNNLTHIPPNLSS--SLKELYIYNN*IQEIQEqDLSGLHNLEILDLSGNcprcynapypcipcpkssiQIHS- 77
Cdd:COG4886  115 LESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNN-------------------QLTDl 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351512  78 -RAFDSLEKLRILRLHSNSLQSIPSSwFRNIKNLKELDLSQNFLmREIGDAqfLTLIPSLVQLDLSFNfelkvyspflNL 156
Cdd:COG4886  175 pEELGNLTNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQL-TDLPEP--LANLTNLETLDLSNN----------QL 240

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 514351512 157 SK--TFSSLANLETLRLKGyvfkeLRAQDLHPLLSLRNLTMLDLGTNFIKIADLTVFEEFPALKFIDLSVNKI 227
Cdd:COG4886  241 TDlpELGNLTNLEELDLSN-----NQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLL 308
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-227 6.79e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.20  E-value: 6.79e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351512   1 LAILSLKSNNLTHIPPNLSS--SLKELYIYNN*IQEIQEqDLSGLHNLEILDLSGNcprcynapypcipcpksSIQIHSR 78
Cdd:COG4886  138 LKELDLSNNQLTDLPEPLGNltNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNN-----------------QITDLPE 199

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351512  79 AFDSLEKLRILRLHSNSLQSIPSSwFRNIKNLKELDLSQNflmrEIGDAQFLTLIPSLVQLDLSFNfELKVYSPFLNLSk 158
Cdd:COG4886  200 PLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNN----QLTDLPELGNLTNLEELDLSNN-QLTDLPPLANLT- 272

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 514351512 159 tfsslaNLETLRLKGYVFKELRAQDLHPLLSLRNLTMLDLGTNFIKIADLTVFEEFPALKFIDLSVNKI 227
Cdd:COG4886  273 ------NLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLV 335
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-214 5.19e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.56  E-value: 5.19e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351512   1 LAILSLKSNNLTHIPPNLS--SSLKELYIYNN*IQEIQEqDLSGLHNLEILDLSGNcpRCYNAPYPCIPCPK------SS 72
Cdd:COG4886  161 LKSLDLSNNQLTDLPEELGnlTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGN--QLTDLPEPLANLTNletldlSN 237

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351512  73 IQIHS-RAFDSLEKLRILRLHSNSLQSIPSSwfRNIKNLKELDLSQNFLMREIGDAQFLTLIPSLVQLDLSFNFELKVYS 151
Cdd:COG4886  238 NQLTDlPELGNLTNLEELDLSNNQLTDLPPL--ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLI 315

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 514351512 152 PFLNLSKTFSSLANLETLRLKGYVFKELRAQDLHPLLSLRNLTMLDLGTNFIKIADLTVFEEF 214
Cdd:COG4886  316 LLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEAT 378
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
4-228 1.27e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 58.41  E-value: 1.27e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351512   4 LSLKSNNLTHIPPNLSSSLKELYIYNN*IQEIQEQDLSGLHNLEILDLSGNcprcynapypcipcpkssiqihsRAFDSL 83
Cdd:COG4886   56 LLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-----------------------EELSNL 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351512  84 EKLRILRLHSNSLQSIPSSwFRNIKNLKELDLSQNFLmREIGDAqfLTLIPSLVQLDLSFNF------------ELKV-- 149
Cdd:COG4886  113 TNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQL-TDLPEP--LGNLTNLKSLDLSNNQltdlpeelgnltNLKEld 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351512 150 --YSPFLNLSKTFSSLANLETLRLKGYVFKELRAqdlhPLLSLRNLTMLDLGTNfiKIADLTVFEEFPALKFIDLSVNKI 227
Cdd:COG4886  189 lsNNQITDLPEPLGNLTNLEELDLSGNQLTDLPE----PLANLTNLETLDLSNN--QLTDLPELGNLTNLEELDLSNNQL 262


                 .
gi 514351512 228 S 228
Cdd:COG4886  263 T 263
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 1-144 8.87e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 54.41  E-value: 8.87e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351512   1 LAILSLKSNNLTHIPpNLSS--SLKELYIYNN*IQEIQeqDLSGLHNLEILDLSGNCPRC----YNAP--------YPCI 66
Cdd:cd21340   26 LKVLYLYDNKITKIE-NLEFltNLTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNRISVveglENLTnleelhieNQRL 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351512  67 PcPKSSIQIHSRAFDSLEK-LRILRLHSNSLQSIpsSWFRNIKNLKELDLSQNFL--MREIgdAQFLTLIPSLVQLDLSF 143
Cdd:cd21340  103 P-PGEKLTFDPRSLAALSNsLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQIsdLEEL--LDLLSSWPSLRELDLTG 177


                 .
gi 514351512 144 N 144
Cdd:cd21340  178 N 178
LRR_8 pfam13855
Leucine rich repeat;
85-144 1.14e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.90  E-value: 1.14e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351512   85 KLRILRLHSNSLQSIPSSWFRNIKNLKELDLSQNfLMREIGDAQFLTLiPSLVQLDLSFN 144
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNN-LLTTLSPGAFSGL-PSLRYLDLSGN 59
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 1-201 1.20e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 52.54  E-value: 1.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351512   1 LAILSLKSNNLT-HIPPNLSS--SLKELYI-YNN*IQEIQEQdLSGLHNLEILDLsgncprCYNAPYPCIPCpkssiqih 76
Cdd:PLN00113 190 LEFLTLASNQLVgQIPRELGQmkSLKWIYLgYNNLSGEIPYE-IGGLTSLNHLDL------VYNNLTGPIPS-------- 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351512  77 srAFDSLEKLRILRLHSNSLQ-SIPSSWFrNIKNLKELDLSQNFLMREIgdAQFLTLIPSLVQLDL-SFNFELKVyspfl 154
Cdd:PLN00113 255 --SLGNLKNLQYLFLYQNKLSgPIPPSIF-SLQKLISLDLSDNSLSGEI--PELVIQLQNLEILHLfSNNFTGKI----- 324

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 514351512 155 nlSKTFSSLANLETL-----RLKGYVFKELRAQDlhpllslrNLTMLDLGTN 201
Cdd:PLN00113 325 --PVALTSLPRLQVLqlwsnKFSGEIPKNLGKHN--------NLTVLDLSTN 366
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 1-228 2.07e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.77  E-value: 2.07e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351512   1 LAILSLKSNNLT-HIPPNLSS--SLKELYIYNN*IQEIQEQDLSGLHNLEILDLSGNCPRCYNAPYPCIPCPKSSIQIHS 77
Cdd:PLN00113 310 LEILHLFSNNFTgKIPVALTSlpRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFS 389

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351512  78 RAFDS--------LEKLRILRLHSNSLQSIPSSWFRNIKNLKELDLSQNFLMREIGDAQFLtlIPSLVQLDLSFNfelkv 149
Cdd:PLN00113 390 NSLEGeipkslgaCRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWD--MPSLQMLSLARN----- 462

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351512 150 ySPFLNLSKTFSSlANLETL-----RLKGYV------FKELRAQDL----------HPLLSLRNLTMLDLGTNFIKIADL 208
Cdd:PLN00113 463 -KFFGGLPDSFGS-KRLENLdlsrnQFSGAVprklgsLSELMQLKLsenklsgeipDELSSCKKLVSLDLSHNQLSGQIP 540

                        250       260
                 ....*....|....*....|
gi 514351512 209 TVFEEFPALKFIDLSVNKIS 228
Cdd:PLN00113 541 ASFSEMPVLSQLDLSQNQLS 560
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 4-198 3.04e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.17  E-value: 3.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351512   4 LSLKSNNLTHIPpNLSS--SLKELYIYNN*IQEIqeQDLSGLHNLEILDLSGNcprcynapypCIpcpkSSIQihsrAFD 81
Cdd:cd21340    7 LYLNDKNITKID-NLSLckNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNN----------QI----EKIE----NLE 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351512  82 SLEKLRILRLHSNSLQSIpsSWFRNIKNLKELDLS-QNFLMRE---IGDAQFLTLIPSLVQLDLSFNfelkvyspflNLS 157
Cdd:cd21340   66 NLVNLKKLYLGGNRISVV--EGLENLTNLEELHIEnQRLPPGEkltFDPRSLAALSNSLRVLNISGN----------NID 133

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 514351512 158 --KTFSSLANLETLRLKGYVFKELRAQdLHPLLSLRNLTMLDL 198
Cdd:cd21340  134 slEPLAPLRNLEQLDASNNQISDLEEL-LDLLSSWPSLRELDL 175
LRR_8 pfam13855
Leucine rich repeat;
1-54 4.80e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 4.80e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 514351512    1 LAILSLKSNNLTHIPPNL---SSSLKELYIYNN*IQEIQEQDLSGLHNLEILDLSGN 54
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAfkgLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 81-228 1.65e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 48.51  E-value: 1.65e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351512  81 DSLEKLRILRLHSNSLQSIP----SSWFRNIKNLKELDLSQNflmrEIGDAQFLTLIP------SLVQLDLSFNFELKVY 150
Cdd:cd00116  134 DLPPALEKLVLGRNRLEGAScealAKALRANRDLKELNLANN----GIGDAGIRALAEglkancNLEVLDLNNNGLTDEG 209

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351512 151 SPFLnlSKTFSSLANLETLRLKGYVFKELRAQDLHPLLSLRNLTMLDLGTNFIKIADL------TVFEEFPALKFIDLSV 224
Cdd:cd00116  210 ASAL--AETLASLKSLEVLNLGDNNLTDAGAAALASALLSPNISLLTLSLSCNDITDDgakdlaEVLAEKESLLELDLRG 287


                 ....
gi 514351512 225 NKIS 228
Cdd:cd00116  288 NKFG 291
LRR_12 pfam18837
Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the ...
 193-222 2.45e-06

Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the pfam00560 model. This entry represents one repeat unit.


Pssm-ID: 408607  Cd Length: 30  Bit Score: 43.10  E-value: 2.45e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 514351512  193 LTMLDLGTNFIKIADLTVFEEFPALKFIDL 222
Cdd:pfam18837   1 LQTLHLQMNFINQAQLSIFGAFPGLRFVDL 30
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-222 3.15e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 44.92  E-value: 3.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351512   1 LAILSLKSNNLTHIPPNLS--SSLKELYIYNN*IQEIQEqdLSGLHNLEILDLSGNcprcynapypcipcpkssiQIHS- 77
Cdd:COG4886  207 LEELDLSGNQLTDLPEPLAnlTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNN-------------------QLTDl 265

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351512  78 RAFDSLEKLRILRLHSNSLQSIPSSWFRNIKNLKELDLSQNFLMREIGDAQFLTLIPSLVQLDLSFNFELKVYSPFLNLS 157
Cdd:COG4886  266 PPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLS 345

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 514351512 158 KTFSSLANLETLRLKGYVFKELRAQDLHPLLSLRNLTMLDLGTNFIKIADLTVFEEFPALKFIDL 222
Cdd:COG4886  346 LLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDA 410
LRR_8 pfam13855
Leucine rich repeat;
20-96 4.06e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.59  E-value: 4.06e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 514351512   20 SSLKELYIYNN*IQEIQEQDLSGLHNLEILDLSGNCPRCynapypcipcpkssiqIHSRAFDSLEKLRILRLHSNSL 96
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT----------------LSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
1-144 8.37e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 43.92  E-value: 8.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351512   1 LAILSLKSNNLTHIPPNLSSSLKELYIYNN*IQEIQEQDLSGLHNLEILDlsgNCPRCYNAPypcIPCPKSSIQIHSRAF 80
Cdd:PRK15370 243 IQEMELSINRITELPERLPSALQSLDLFHNKISCLPENLPEELRYLSVYD---NSIRTLPAH---LPSGITHLNVQSNSL 316

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 514351512  81 DSLEK-----LRILRLHSNSLQSIPSSWFRNIKNlkeLDLSQN--FLMREigdaqflTLIPSLVQLDLSFN 144
Cdd:PRK15370 317 TALPEtlppgLKTLEAGENALTSLPASLPPELQV---LDVSKNqiTVLPE-------TLPPTITTLDVSRN 377
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 1-203 8.73e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 43.68  E-value: 8.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351512   1 LAILSLKSNNLT-HIPPNLSSSLKELYIYNN*IQEIQEQDLSGLHNLEILDLSGNCPRCYNAPYpcipcpkssiqihsra 79
Cdd:PLN00113 120 LRYLNLSNNNFTgSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNS---------------- 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351512  80 FDSLEKLRILRLHSNSLQSIPSSWFRNIKNLKELDLSQNFLMREIGDAqfLTLIPSLVQLDLSFNfelkvyspflNLSKT 159
Cdd:PLN00113 184 LTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYE--IGGLTSLNHLDLVYN----------NLTGP 251

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 514351512 160 F-SSLANLETLRlkgYVF---KELRAQDLHPLLSLRNLTMLDLGTNFI 203
Cdd:PLN00113 252 IpSSLGNLKNLQ---YLFlyqNKLSGPIPPSIFSLQKLISLDLSDNSL 296
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
4-144 1.03e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 43.53  E-value: 1.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351512   4 LSLKSNNLTHIPPNLSSSLKELYIYNN*IQEIQEqdlSGLHNLEILDLSGNcpRCYNAPYPcIPCPKSSIQIHSRAFDSL 83
Cdd:PRK15370 204 LILDNNELKSLPENLQGNIKTLYANSNQLTSIPA---TLPDTIQEMELSIN--RITELPER-LPSALQSLDLFHNKISCL 277

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 514351512  84 -----EKLRILRLHSNSLQSIPSSWFRNIKNLKELDLSQNFLMREI--------GDAQFLT-----LIPSLVQLDLSFN 144
Cdd:PRK15370 278 penlpEELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPETLppglktleAGENALTslpasLPPELQVLDVSKN 356
LRR_8 pfam13855
Leucine rich repeat;
75-118 2.02e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.66  E-value: 2.02e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 514351512   75 IHSRAFDSLEKLRILRLHSNSLQSIPSSWFRNIKNLKELDLSQN 118
Cdd:pfam13855  16 LDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 4-228 3.91e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.76  E-value: 3.91e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351512   4 LSLKSNNLT-HIPPNLS--SSLKELYIYNN*IQEIQEQDLSGLHNLEILDLSGNCprcYNAPYPCIPCPKSSIQI-H--- 76
Cdd:PLN00113 241 LDLVYNNLTgPIPSSLGnlKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNS---LSGEIPELVIQLQNLEIlHlfs 317

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351512  77 -------SRAFDSLEKLRILRLHSNSLQ-SIPSSWFRNiKNLKELDLSQNFLMREIGDaqflTLIPSlvqldlSFNFELK 148
Cdd:PLN00113 318 nnftgkiPVALTSLPRLQVLQLWSNKFSgEIPKNLGKH-NNLTVLDLSTNNLTGEIPE----GLCSS------GNLFKLI 386

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351512 149 VYSPFLN--LSKTFSSLANLETLRLKGYVFKELRAQDlhpLLSLRNLTMLDLGTNFIKIADLTVFEEFPALKFIDLSVNK 226
Cdd:PLN00113 387 LFSNSLEgeIPKSLGACRSLRRVRLQDNSFSGELPSE---FTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNK 463


                 ..
gi 514351512 227 IS 228
Cdd:PLN00113 464 FF 465
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 1-144 9.65e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.60  E-value: 9.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351512   1 LAILSLKSNNLTHIPPNLSSS--LKELYIYNN*IQEIQEQDLSGLHNLEILDLSGNcprcynapypcipcpKSSIQIhSR 78
Cdd:PLN00113 454 LQMLSLARNKFFGGLPDSFGSkrLENLDLSRNQFSGAVPRKLGSLSELMQLKLSEN---------------KLSGEI-PD 517

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 514351512  79 AFDSLEKLRILRLHSNSLQ-SIPSSwFRNIKNLKELDLSQNFLMREIgdAQFLTLIPSLVQLDLSFN 144
Cdd:PLN00113 518 ELSSCKKLVSLDLSHNQLSgQIPAS-FSEMPVLSQLDLSQNQLSGEI--PKNLGNVESLVQVNISHN 581
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 18-114 3.21e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 37.84  E-value: 3.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351512  18 LSSSLKELYIYNN*IQEIQeqDLSGLHNLEILDLSGNcprcynapypCIpcpkSSIQIHSRAFDSLEKLRILRLHSNSLQ 97
Cdd:cd21340  118 LSNSLRVLNISGNNIDSLE--PLAPLRNLEQLDASNN----------QI----SDLEELLDLLSSWPSLRELDLTGNPVC 181

                         90       100
                 ....*....|....*....|..
gi 514351512  98 SIPSswFR-----NIKNLKELD 114
Cdd:cd21340  182 KKPK--YRdkiilASKSLEVLD 201
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 21-54 3.36e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.91  E-value: 3.36e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 514351512   21 SLKELYIYNN*IQEIQEqdLSGLHNLEILDLSGN 54
Cdd:pfam12799   2 NLEVLDLSNNQITDIPP--LAKLPNLETLDLSGN 33
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 85-126 9.65e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 33.37  E-value: 9.65e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 514351512   85 KLRILRLHSNSLQSIPSswFRNIKNLKELDLSQNFLMREIGD 126
Cdd:pfam12799   2 NLEVLDLSNNQITDIPP--LAKLPNLETLDLSGNNKITDLSD 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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