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Conserved domains on  [gi|514351520|gb|AGO49941|]
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Toll-like receptor 7, partial [Notiomystis cincta]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-227 1.08e-17

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 82.29  E-value: 1.08e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351520   1 LTILSLKSNNLTRIPPNLSS--TLKELYIYNNMIEEIQDqDLSGLPNLEILDLSGNcprcynapypcipcpkssiQIHS- 77
Cdd:COG4886  115 LESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNN-------------------QLTDl 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351520  78 -AAFDSLENLRVLRLHSNSLQSVPSSwFKNIRNLKELDLSQNFLmREIGDAqfLTFIPSLVHLDLSFNfqlkmyspflNL 156
Cdd:COG4886  175 pEELGNLTNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQL-TDLPEP--LANLTNLETLDLSNN----------QL 240

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 514351520 157 SK--TFSSLSNLETLRLKGyvfkeLRAQDLHPLLSLRNLTMLDLGTNFIKVADLTVFEKFPALKFIDLSVNKI 227
Cdd:COG4886  241 TDlpELGNLTNLEELDLSN-----NQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLL 308
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-227 1.08e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 82.29  E-value: 1.08e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351520   1 LTILSLKSNNLTRIPPNLSS--TLKELYIYNNMIEEIQDqDLSGLPNLEILDLSGNcprcynapypcipcpkssiQIHS- 77
Cdd:COG4886  115 LESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNN-------------------QLTDl 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351520  78 -AAFDSLENLRVLRLHSNSLQSVPSSwFKNIRNLKELDLSQNFLmREIGDAqfLTFIPSLVHLDLSFNfqlkmyspflNL 156
Cdd:COG4886  175 pEELGNLTNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQL-TDLPEP--LANLTNLETLDLSNN----------QL 240

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 514351520 157 SK--TFSSLSNLETLRLKGyvfkeLRAQDLHPLLSLRNLTMLDLGTNFIKVADLTVFEKFPALKFIDLSVNKI 227
Cdd:COG4886  241 TDlpELGNLTNLEELDLSN-----NQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLL 308
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 1-173 1.37e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 56.72  E-value: 1.37e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351520   1 LTILSLKSNNLTRIPpNLSST--LKELYIYNNMIEEIQDqdLSGLPNLEILDLSGNCPRCYNapypcipcpkssiqihsa 78
Cdd:cd21340   26 LKVLYLYDNKITKIE-NLEFLtnLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVE------------------ 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351520  79 AFDSLENLRVLRLHSNSLQSVPSSWF-----KNIRN-LKELDLSQNflmrEIGDAQFLTFIPSLVHLDLSFNfQLkmySP 152
Cdd:cd21340   85 GLENLTNLEELHIENQRLPPGEKLTFdprslAALSNsLRVLNISGN----NIDSLEPLAPLRNLEQLDASNN-QI---SD 156

                        170       180
                 ....*....|....*....|.
gi 514351520 153 FLNLSKTFSSLSNLETLRLKG 173
Cdd:cd21340  157 LEELLDLLSSWPSLRELDLTG 177
LRR_8 pfam13855
Leucine rich repeat;
85-144 3.61e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 3.61e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351520   85 NLRVLRLHSNSLQSVPSSWFKNIRNLKELDLSQNfLMREIGDAQFlTFIPSLVHLDLSFN 144
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNN-LLTTLSPGAF-SGLPSLRYLDLSGN 59
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 1-201 8.20e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 53.31  E-value: 8.20e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351520   1 LTILSLKSNNLT-RIPPNLSS--TLKELYI-YNNMIEEIQDQdLSGLPNLEILDLsgncprCYNAPYPCIPcpkssiqih 76
Cdd:PLN00113 190 LEFLTLASNQLVgQIPRELGQmkSLKWIYLgYNNLSGEIPYE-IGGLTSLNHLDL------VYNNLTGPIP--------- 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351520  77 sAAFDSLENLRVLRLHSNSLQ-SVPSSWFkNIRNLKELDLSQNFLMREIGD--AQFLTFipSLVHLdLSFNFQLKmyspf 153
Cdd:PLN00113 254 -SSLGNLKNLQYLFLYQNKLSgPIPPSIF-SLQKLISLDLSDNSLSGEIPElvIQLQNL--EILHL-FSNNFTGK----- 323

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 514351520 154 lnLSKTFSSLSNLETL-----RLKGYVFKELRAQDlhpllslrNLTMLDLGTN 201
Cdd:PLN00113 324 --IPVALTSLPRLQVLqlwsnKFSGEIPKNLGKHN--------NLTVLDLSTN 366
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-227 1.08e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 82.29  E-value: 1.08e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351520   1 LTILSLKSNNLTRIPPNLSS--TLKELYIYNNMIEEIQDqDLSGLPNLEILDLSGNcprcynapypcipcpkssiQIHS- 77
Cdd:COG4886  115 LESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNN-------------------QLTDl 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351520  78 -AAFDSLENLRVLRLHSNSLQSVPSSwFKNIRNLKELDLSQNFLmREIGDAqfLTFIPSLVHLDLSFNfqlkmyspflNL 156
Cdd:COG4886  175 pEELGNLTNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQL-TDLPEP--LANLTNLETLDLSNN----------QL 240

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 514351520 157 SK--TFSSLSNLETLRLKGyvfkeLRAQDLHPLLSLRNLTMLDLGTNFIKVADLTVFEKFPALKFIDLSVNKI 227
Cdd:COG4886  241 TDlpELGNLTNLEELDLSN-----NQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLL 308
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
20-228 1.12e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.59  E-value: 1.12e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351520  20 STLKELYIYNNMIEEIqDQDLSGLPNLEILDLSGNcprcynapypcipcpkssiQIHS--AAFDSLENLRVLRLHSNSLQ 97
Cdd:COG4886  113 TNLESLDLSGNQLTDL-PEELANLTNLKELDLSNN-------------------QLTDlpEPLGNLTNLKSLDLSNNQLT 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351520  98 SVPSSwFKNIRNLKELDLSQNFLmREIGDAqfLTFIPSLVHLDLSFNfQLKmyspflNLSKTFSSLSNLETLRLKGyvfk 177
Cdd:COG4886  173 DLPEE-LGNLTNLKELDLSNNQI-TDLPEP--LGNLTNLEELDLSGN-QLT------DLPEPLANLTNLETLDLSN---- 237

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 514351520 178 eLRAQDLHPLLSLRNLTMLDLGTNFIKvaDLTVFEKFPALKFIDLSVNKIS 228
Cdd:COG4886  238 -NQLTDLPELGNLTNLEELDLSNNQLT--DLPPLANLTNLKTLDLSNNQLT 285
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-227 1.55e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.82  E-value: 1.55e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351520   1 LTILSLKSNNLTRIPPNLSS--TLKELYIYNNMIEEIqDQDLSGLPNLEILDLSGNcprcynapypcipcpksSIQIHSA 78
Cdd:COG4886  138 LKELDLSNNQLTDLPEPLGNltNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNN-----------------QITDLPE 199

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351520  79 AFDSLENLRVLRLHSNSLQSVPSSwFKNIRNLKELDLSQNflmrEIGDAQFLTFIPSLVHLDLSFNfQLKMYSPFLNLSk 158
Cdd:COG4886  200 PLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNN----QLTDLPELGNLTNLEELDLSNN-QLTDLPPLANLT- 272

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 514351520 159 tfsslsNLETLRLKGYVFKELRAQDLHPLLSLRNLTMLDLGTNFIKVADLTVFEKFPALKFIDLSVNKI 227
Cdd:COG4886  273 ------NLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLV 335
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-228 3.05e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 69.19  E-value: 3.05e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351520   1 LTILSLKSNNLTRIPPNLSSTLKELYIYNNMIEEIQDQDLSGLPNLEILDLSGNCPRCYNAPYPCIPCPKSSIQIHSAAF 80
Cdd:COG4886   53 LSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEEL 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351520  81 DSLENLRVLRLHSNSLQSVPSSwFKNIRNLKELDLSQNFLmREIGDAqfLTFIPSLVHLDLSFNfqlkmysPFLNLSKTF 160
Cdd:COG4886  133 ANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQL-TDLPEE--LGNLTNLKELDLSNN-------QITDLPEPL 201

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 514351520 161 SSLSNLETLRLKGYVFKELRAqdlhPLLSLRNLTMLDLGTNfiKVADLTVFEKFPALKFIDLSVNKIS 228
Cdd:COG4886  202 GNLTNLEELDLSGNQLTDLPE----PLANLTNLETLDLSNN--QLTDLPELGNLTNLEELDLSNNQLT 263
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-212 1.20e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 61.49  E-value: 1.20e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351520   1 LTILSLKSNNLTRIPPNLS--STLKELYIYNNMIEEIqDQDLSGLPNLEILDLSGNcprcynapypcipcpkssiQIHS- 77
Cdd:COG4886  184 LKELDLSNNQITDLPEPLGnlTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNN-------------------QLTDl 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351520  78 AAFDSLENLRVLRLHSNSLQSVPSSwfKNIRNLKELDLSQNFLMREIGDAQFLTFIPSLVHLDLSFNFQLKMYSPFLNLS 157
Cdd:COG4886  244 PELGNLTNLEELDLSNNQLTDLPPL--ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLT 321

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 514351520 158 KTFSSLSNLETLRLKGYVFKELRAQDLHPLLSLRNLTMLDLGTNFIKVADLTVFE 212
Cdd:COG4886  322 TLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLE 376
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 1-173 1.37e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 56.72  E-value: 1.37e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351520   1 LTILSLKSNNLTRIPpNLSST--LKELYIYNNMIEEIQDqdLSGLPNLEILDLSGNCPRCYNapypcipcpkssiqihsa 78
Cdd:cd21340   26 LKVLYLYDNKITKIE-NLEFLtnLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVE------------------ 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351520  79 AFDSLENLRVLRLHSNSLQSVPSSWF-----KNIRN-LKELDLSQNflmrEIGDAQFLTFIPSLVHLDLSFNfQLkmySP 152
Cdd:cd21340   85 GLENLTNLEELHIENQRLPPGEKLTFdprslAALSNsLRVLNISGN----NIDSLEPLAPLRNLEQLDASNN-QI---SD 156

                        170       180
                 ....*....|....*....|.
gi 514351520 153 FLNLSKTFSSLSNLETLRLKG 173
Cdd:cd21340  157 LEELLDLLSSWPSLRELDLTG 177
LRR_8 pfam13855
Leucine rich repeat;
85-144 3.61e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 3.61e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351520   85 NLRVLRLHSNSLQSVPSSWFKNIRNLKELDLSQNfLMREIGDAQFlTFIPSLVHLDLSFN 144
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNN-LLTTLSPGAF-SGLPSLRYLDLSGN 59
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 1-201 8.20e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 53.31  E-value: 8.20e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351520   1 LTILSLKSNNLT-RIPPNLSS--TLKELYI-YNNMIEEIQDQdLSGLPNLEILDLsgncprCYNAPYPCIPcpkssiqih 76
Cdd:PLN00113 190 LEFLTLASNQLVgQIPRELGQmkSLKWIYLgYNNLSGEIPYE-IGGLTSLNHLDL------VYNNLTGPIP--------- 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351520  77 sAAFDSLENLRVLRLHSNSLQ-SVPSSWFkNIRNLKELDLSQNFLMREIGD--AQFLTFipSLVHLdLSFNFQLKmyspf 153
Cdd:PLN00113 254 -SSLGNLKNLQYLFLYQNKLSgPIPPSIF-SLQKLISLDLSDNSLSGEIPElvIQLQNL--EILHL-FSNNFTGK----- 323

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 514351520 154 lnLSKTFSSLSNLETL-----RLKGYVFKELRAQDlhpllslrNLTMLDLGTN 201
Cdd:PLN00113 324 --IPVALTSLPRLQVLqlwsnKFSGEIPKNLGKHN--------NLTVLDLSTN 366
LRR_8 pfam13855
Leucine rich repeat;
1-54 2.08e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.13  E-value: 2.08e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 514351520    1 LTILSLKSNNLTRIPP----NLSStLKELYIYNNMIEEIQDQDLSGLPNLEILDLSGN 54
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDgafkGLSN-LKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR_12 pfam18837
Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the ...
 193-222 3.32e-07

Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the pfam00560 model. This entry represents one repeat unit.


Pssm-ID: 408607  Cd Length: 30  Bit Score: 45.80  E-value: 3.32e-07
                          10        20        30
                  ....*....|....*....|....*....|
gi 514351520  193 LTMLDLGTNFIKVADLTVFEKFPALKFIDL 222
Cdd:pfam18837   1 LQTLHLQMNFINQAQLSIFGAFPGLRFVDL 30
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 1-203 7.69e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 50.23  E-value: 7.69e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351520   1 LTILSLKSNNLT-RIPPNLSSTLKELYIYNNMIEEIQDQDLSGLPNLEILDLSGncprcyNAPYPCIPcpkssiqihsAA 79
Cdd:PLN00113 120 LRYLNLSNNNFTgSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGG------NVLVGKIP----------NS 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351520  80 FDSLENLRVLRLHSNSLQSVPSSWFKNIRNLKELDLSQNFLMREIGDAqfLTFIPSLVHLDLSFNfqlkmyspflNLSKT 159
Cdd:PLN00113 184 LTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYE--IGGLTSLNHLDLVYN----------NLTGP 251

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 514351520 160 F-SSLSNLETLRlkgYVF---KELRAQDLHPLLSLRNLTMLDLGTNFI 203
Cdd:PLN00113 252 IpSSLGNLKNLQ---YLFlyqNKLSGPIPPSIFSLQKLISLDLSDNSL 296
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 1-228 7.94e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.15  E-value: 7.94e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351520   1 LTILSLKSNNLT-RIPPNL--SSTLKELYIYNNMIEEIQDQDLSGLPNLEILDL-----SGNCPRcynapypcipcpkss 72
Cdd:PLN00113 358 LTVLDLSTNNLTgEIPEGLcsSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLqdnsfSGELPS--------------- 422

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351520  73 iqihsaAFDSLENLRVLRLHSNSLQSVPSSWFKNIRNLKELDLSQNFLMREIGDaqfLTFIPSLVHLDLSFNfQLKMYSP 152
Cdd:PLN00113 423 ------EFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLPD---SFGSKRLENLDLSRN-QFSGAVP 492

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 514351520 153 flnlsKTFSSLSNLETLRLKGyvfKELRAQDLHPLLSLRNLTMLDLGTNFIKVADLTVFEKFPALKFIDLSVNKIS 228
Cdd:PLN00113 493 -----RKLGSLSELMQLKLSE---NKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLS 560
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 1-228 8.45e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 46.58  E-value: 8.45e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351520   1 LTILSLKSNNLTRIPPNL---------SSTLKELYIYNNMIEEIQD---QDLSGLPNLEILDLSGNcprcynapypciPC 68
Cdd:cd00116   53 LKELCLSLNETGRIPRGLqsllqgltkGCGLQELDLSDNALGPDGCgvlESLLRSSSLQELKLNNN------------GL 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351520  69 PKSSIQIHSAAF-DSLENLRVLRLHSNSLQSVP----SSWFKNIRNLKELDLSQNflmrEIGD------AQFLTFIPSLV 137
Cdd:cd00116  121 GDRGLRLLAKGLkDLPPALEKLVLGRNRLEGAScealAKALRANRDLKELNLANN----GIGDagiralAEGLKANCNLE 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351520 138 HLDLSFNFqlkmyspfLN------LSKTFSSLSNLETLRLKGYVFKELRAQDLHPLLSLRNLTM--LDLGTNFIK----V 205
Cdd:cd00116  197 VLDLNNNG--------LTdegasaLAETLASLKSLEVLNLGDNNLTDAGAAALASALLSPNISLltLSLSCNDITddgaK 268

                        250       260
                 ....*....|....*....|...
gi 514351520 206 ADLTVFEKFPALKFIDLSVNKIS 228
Cdd:cd00116  269 DLAEVLAEKESLLELDLRGNKFG 291
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
1-120 2.02e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 45.84  E-value: 2.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351520   1 LTILSLKSNNLTRIPPNLSSTLKELYIYNNMIEEIQDQdlsgLPN-LEILDLSGNcpRCYNAPYPcIPCPKSSIQIHSAA 79
Cdd:PRK15370 201 ITTLILDNNELKSLPENLQGNIKTLYANSNQLTSIPAT----LPDtIQEMELSIN--RITELPER-LPSALQSLDLFHNK 273

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 514351520  80 FDSL-----ENLRVLRLHSNSLQSVPSSWFKNIRNLKELDLSQNFL 120
Cdd:PRK15370 274 ISCLpenlpEELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTAL 319
LRR_8 pfam13855
Leucine rich repeat;
44-118 3.40e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.97  E-value: 3.40e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 514351520   44 PNLEILDLSGNcprcynapypcipcpksSIQ-IHSAAFDSLENLRVLRLHSNSLQSVPSSWFKNIRNLKELDLSQN 118
Cdd:pfam13855   1 PNLRSLDLSNN-----------------RLTsLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
20-96 1.11e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.43  E-value: 1.11e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 514351520   20 STLKELYIYNNMIEEIQDQDLSGLPNLEILDLSGNCPRCynapypcipcpkssiqIHSAAFDSLENLRVLRLHSNSL 96
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT----------------LSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 1-228 3.26e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.14  E-value: 3.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351520   1 LTILSLKSNNLT-RIPPNLS--STLKELYIYNNMIEEIQDQDLSGLPNLEILDLSGNCprcYNAPYPCIPCPKSSIQI-H 76
Cdd:PLN00113 238 LNHLDLVYNNLTgPIPSSLGnlKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNS---LSGEIPELVIQLQNLEIlH 314

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351520  77 ----------SAAFDSLENLRVLRLHSNSLQ-SVPSSWFKNiRNLKELDLSQNFLMREIGDAqfltfIPSLVHLdlsfnF 145
Cdd:PLN00113 315 lfsnnftgkiPVALTSLPRLQVLQLWSNKFSgEIPKNLGKH-NNLTVLDLSTNNLTGEIPEG-----LCSSGNL-----F 383

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351520 146 QLKMYSPFLN--LSKTFSSLSNLETLRLKGYVFKELRAQDlhpLLSLRNLTMLDLGTNFIKVADLTVFEKFPALKFIDLS 223
Cdd:PLN00113 384 KLILFSNSLEgeIPKSLGACRSLRRVRLQDNSFSGELPSE---FTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLA 460


                 ....*
gi 514351520 224 VNKIS 228
Cdd:PLN00113 461 RNKFF 465
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 80-228 1.96e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.61  E-value: 1.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351520  80 FDSLENLRVLRLHSNSLQSVPSswFKNIRNLKELDLSQNFLmREIGDAQFLtfiPSLVHLDLSFNfqlkmyspflNLSKT 159
Cdd:cd21340   20 LSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQI-EKIENLENL---VNLKKLYLGGN----------RISVV 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351520 160 --FSSLSNLETLRLKGyvfkelraQDLHP----------LLSLRN-LTMLDLGTNfiKVADLTVFEKFPALKFIDLSVNK 226
Cdd:cd21340   84 egLENLTNLEELHIEN--------QRLPPgekltfdprsLAALSNsLRVLNISGN--NIDSLEPLAPLRNLEQLDASNNQ 153


                 ..
gi 514351520 227 IS 228
Cdd:cd21340  154 IS 155
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 22-54 2.86e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.91  E-value: 2.86e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 514351520   22 LKELYIYNNMIEEIQDqdLSGLPNLEILDLSGN 54
Cdd:pfam12799   3 LEVLDLSNNQITDIPP--LAKLPNLETLDLSGN 33
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 42-231 3.73e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 38.68  E-value: 3.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351520  42 GLPNLEILDLSGNcprcynapypcipcpKSSIQIHSAAFDSLENLRVLRLHSNSLQ-SVPSSwfkNIRNLKELDLSQNFL 120
Cdd:PLN00113  91 RLPYIQTINLSNN---------------QLSGPIPDDIFTTSSSLRYLNLSNNNFTgSIPRG---SIPNLETLDLSNNML 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351520 121 MREIgdAQFLTFIPSLVHLDLSFNFQlkmyspflnLSKTFSSLSNLETLRLKGYVFKELRAQDLHPLLSLRNLTMLDLGT 200
Cdd:PLN00113 153 SGEI--PNDIGSFSSLKVLDLGGNVL---------VGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGY 221

                        170       180       190
                 ....*....|....*....|....*....|....
gi 514351520 201 NFIKVADLTVFEKFPALKFIDLSVNKIS---PSS 231
Cdd:PLN00113 222 NNLSGEIPYEIGGLTSLNHLDLVYNNLTgpiPSS 255
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 85-126 4.83e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.14  E-value: 4.83e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 514351520   85 NLRVLRLHSNSLQSVPSswFKNIRNLKELDLSQNFLMREIGD 126
Cdd:pfam12799   2 NLEVLDLSNNQITDIPP--LAKLPNLETLDLSGNNKITDLSD 41
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 1-144 7.94e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 37.91  E-value: 7.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351520   1 LTILSLKSNNLTRIPPNL--SSTLKELYIYNNMIEEIQDQDLSGLPNLEILDLSGNcprcynapypcipcpKSSIQIHSA 78
Cdd:PLN00113 454 LQMLSLARNKFFGGLPDSfgSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSEN---------------KLSGEIPDE 518

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 514351520  79 aFDSLENLRVLRLHSNSLQ-SVPSSwFKNIRNLKELDLSQNFLMREIgdAQFLTFIPSLVHLDLSFN 144
Cdd:PLN00113 519 -LSSCKKLVSLDLSHNQLSgQIPAS-FSEMPVLSQLDLSQNQLSGEI--PKNLGNVESLVQVNISHN 581
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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