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Conserved domains on  [gi|514351522|gb|AGO49942|]
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Toll-like receptor 7, partial [Notiomystis cincta]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-234 2.22e-18

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.60  E-value: 2.22e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351522   1 AFLGLKRLTILSLKSNNLTRIPPNLS*--TLKELYIYNNMIEEIQDqDLSGLPNLEILDLSGNcprcynapypcipcpks 78
Cdd:COG4886  108 ELSNLTNLESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNN----------------- 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351522  79 siQIHS--AAFDSLENLRVLRLHSNSLQSVPSSwFKNIRNLKELDLSQNFLmREIGDAqfLTFIPSLVHLDLSFNfqlkm 156
Cdd:COG4886  170 --QLTDlpEELGNLTNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQL-TDLPEP--LANLTNLETLDLSNN----- 238

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351522 157 yspflNLSK--TFSSLSNLETLRLKGyvfkeLRAQDLHPLLSLRNLTMLDLGTNFIKVADLTVFEKFPALKFIDLSVNKI 234
Cdd:COG4886  239 -----QLTDlpELGNLTNLEELDLSN-----NQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLL 308
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-234 2.22e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.60  E-value: 2.22e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351522   1 AFLGLKRLTILSLKSNNLTRIPPNLS*--TLKELYIYNNMIEEIQDqDLSGLPNLEILDLSGNcprcynapypcipcpks 78
Cdd:COG4886  108 ELSNLTNLESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNN----------------- 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351522  79 siQIHS--AAFDSLENLRVLRLHSNSLQSVPSSwFKNIRNLKELDLSQNFLmREIGDAqfLTFIPSLVHLDLSFNfqlkm 156
Cdd:COG4886  170 --QLTDlpEELGNLTNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQL-TDLPEP--LANLTNLETLDLSNN----- 238

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351522 157 yspflNLSK--TFSSLSNLETLRLKGyvfkeLRAQDLHPLLSLRNLTMLDLGTNFIKVADLTVFEKFPALKFIDLSVNKI 234
Cdd:COG4886  239 -----QLTDlpELGNLTNLEELDLSN-----NQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLL 308
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 5-205 1.73e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 59.41  E-value: 1.73e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351522   5 LKRLTILSLKSNNLTRIpPNLS*T--LKELYIYNNMIEEIqdQDLSGLPNLEILDLSGNcprcynapypCIpcpkSSIQi 82
Cdd:cd21340    1 LKRITHLYLNDKNITKI-DNLSLCknLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNN----------QI----EKIE- 62

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351522  83 hsaAFDSLENLRVLRLHSNSLQSVpsSWFKNIRNLKELDLS-QNflmreIGDAQFLTFIP--------SLVHLDLSFNfq 153
Cdd:cd21340   63 ---NLENLVNLKKLYLGGNRISVV--EGLENLTNLEELHIEnQR-----LPPGEKLTFDPrslaalsnSLRVLNISGN-- 130

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 514351522 154 lkmyspflNLS--KTFSSLSNLETLRLKGYVFKELRAQdLHPLLSLRNLTMLDL 205
Cdd:cd21340  131 --------NIDslEPLAPLRNLEQLDASNNQISDLEEL-LDLLSSWPSLRELDL 175
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 5-208 1.73e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 55.62  E-value: 1.73e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351522   5 LKRLTILSLKSNNLT-RIPPNLS*--TLKELYI-YNNMIEEIQDQdLSGLPNLEILDLsgncprCYNAPYPCIPcpkssi 80
Cdd:PLN00113 187 LTSLEFLTLASNQLVgQIPRELGQmkSLKWIYLgYNNLSGEIPYE-IGGLTSLNHLDL------VYNNLTGPIP------ 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351522  81 qihsAAFDSLENLRVLRLHSNSLQ-SVPSSWFkNIRNLKELDLSQNFLMREIGD--AQFLTFipSLVHLdLSFNFQLKmy 157
Cdd:PLN00113 254 ----SSLGNLKNLQYLFLYQNKLSgPIPPSIF-SLQKLISLDLSDNSLSGEIPElvIQLQNL--EILHL-FSNNFTGK-- 323

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 514351522 158 spflnLSKTFSSLSNLETL-----RLKGYVFKELRAQDlhpllslrNLTMLDLGTN 208
Cdd:PLN00113 324 -----IPVALTSLPRLQVLqlwsnKFSGEIPKNLGKHN--------NLTVLDLSTN 366
LRR_8 pfam13855
Leucine rich repeat;
92-151 3.74e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 3.74e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351522   92 NLRVLRLHSNSLQSVPSSWFKNIRNLKELDLSQNfLMREIGDAQFlTFIPSLVHLDLSFN 151
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNN-LLTTLSPGAF-SGLPSLRYLDLSGN 59
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-234 2.22e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.60  E-value: 2.22e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351522   1 AFLGLKRLTILSLKSNNLTRIPPNLS*--TLKELYIYNNMIEEIQDqDLSGLPNLEILDLSGNcprcynapypcipcpks 78
Cdd:COG4886  108 ELSNLTNLESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNN----------------- 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351522  79 siQIHS--AAFDSLENLRVLRLHSNSLQSVPSSwFKNIRNLKELDLSQNFLmREIGDAqfLTFIPSLVHLDLSFNfqlkm 156
Cdd:COG4886  170 --QLTDlpEELGNLTNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQL-TDLPEP--LANLTNLETLDLSNN----- 238

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351522 157 yspflNLSK--TFSSLSNLETLRLKGyvfkeLRAQDLHPLLSLRNLTMLDLGTNFIKVADLTVFEKFPALKFIDLSVNKI 234
Cdd:COG4886  239 -----QLTDlpELGNLTNLEELDLSN-----NQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLL 308
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
4-234 2.89e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.13  E-value: 2.89e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351522   4 GLKRLTILSLKSNNLTRIPPNLS*--TLKELYIYNNMIEEIqDQDLSGLPNLEILDLSGNcprcynapypcipcpksSIQ 81
Cdd:COG4886  134 NLTNLKELDLSNNQLTDLPEPLGNltNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNN-----------------QIT 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351522  82 IHSAAFDSLENLRVLRLHSNSLQSVPSSwFKNIRNLKELDLSQNflmrEIGDAQFLTFIPSLVHLDLSFNfQLKMYSPFL 161
Cdd:COG4886  196 DLPEPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNN----QLTDLPELGNLTNLEELDLSNN-QLTDLPPLA 269

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 514351522 162 NlsktfssLSNLETLRLKGYVFKELRAQDLHPLLSLRNLTMLDLGTNFIKVADLTVFEKFPALKFIDLSVNKI 234
Cdd:COG4886  270 N-------LTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLV 335
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
5-235 1.89e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 69.96  E-value: 1.89e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351522   5 LKRLTILSLKSNNLTRIPPNLS*TLKELYIYNNMIEEIQDQDLSGLPNLEILDLSGNCPRCYNAPYPCIPCPKSSIQIHS 84
Cdd:COG4886   50 TLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLP 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351522  85 AAFDSLENLRVLRLHSNSLQSVPSSwFKNIRNLKELDLSQNFLmREIGDAqfLTFIPSLVHLDLSFNfqlkmysPFLNLS 164
Cdd:COG4886  130 EELANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQL-TDLPEE--LGNLTNLKELDLSNN-------QITDLP 198

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 514351522 165 KTFSSLSNLETLRLKGYVFKELRAqdlhPLLSLRNLTMLDLGTNfiKVADLTVFEKFPALKFIDLSVNKIS 235
Cdd:COG4886  199 EPLGNLTNLEELDLSGNQLTDLPE----PLANLTNLETLDLSNN--QLTDLPELGNLTNLEELDLSNNQLT 263
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-219 8.01e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.95  E-value: 8.01e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351522   1 AFLGLKRLTILSLKSNNLTRIPPNLS--*TLKELYIYNNMIEEIqDQDLSGLPNLEILDLSGNcprcynapypcipcpks 78
Cdd:COG4886  177 ELGNLTNLKELDLSNNQITDLPEPLGnlTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNN----------------- 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351522  79 siQIHS-AAFDSLENLRVLRLHSNSLQSVPSSwfKNIRNLKELDLSQNFLMREIGDAQFLTFIPSLVHLDLSFNFQLKMY 157
Cdd:COG4886  239 --QLTDlPELGNLTNLEELDLSNNQLTDLPPL--ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELL 314

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 514351522 158 SPFLNLSKTFSSLSNLETLRLKGYVFKELRAQDLHPLLSLRNLTMLDLGTNFIKVADLTVFE 219
Cdd:COG4886  315 ILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLE 376
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 5-205 1.73e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 59.41  E-value: 1.73e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351522   5 LKRLTILSLKSNNLTRIpPNLS*T--LKELYIYNNMIEEIqdQDLSGLPNLEILDLSGNcprcynapypCIpcpkSSIQi 82
Cdd:cd21340    1 LKRITHLYLNDKNITKI-DNLSLCknLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNN----------QI----EKIE- 62

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351522  83 hsaAFDSLENLRVLRLHSNSLQSVpsSWFKNIRNLKELDLS-QNflmreIGDAQFLTFIP--------SLVHLDLSFNfq 153
Cdd:cd21340   63 ---NLENLVNLKKLYLGGNRISVV--EGLENLTNLEELHIEnQR-----LPPGEKLTFDPrslaalsnSLRVLNISGN-- 130

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 514351522 154 lkmyspflNLS--KTFSSLSNLETLRLKGYVFKELRAQdLHPLLSLRNLTMLDL 205
Cdd:cd21340  131 --------NIDslEPLAPLRNLEQLDASNNQISDLEEL-LDLLSSWPSLRELDL 175
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 6-180 2.39e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 56.33  E-value: 2.39e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351522   6 KRLTILSLKSNNLTRIPpNLS*T--LKELYIYNNMIEEIQDqdLSGLPNLEILDLSGNCPRCYNapypcipcpkssiqih 83
Cdd:cd21340   24 KNLKVLYLYDNKITKIE-NLEFLtnLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVE---------------- 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351522  84 saAFDSLENLRVLRLHSNSLQSVPSSWF-----KNIRN-LKELDLSQNflmrEIGDAQFLTFIPSLVHLDLSFNfQLkmy 157
Cdd:cd21340   85 --GLENLTNLEELHIENQRLPPGEKLTFdprslAALSNsLRVLNISGN----NIDSLEPLAPLRNLEQLDASNN-QI--- 154

                        170       180
                 ....*....|....*....|...
gi 514351522 158 SPFLNLSKTFSSLSNLETLRLKG 180
Cdd:cd21340  155 SDLEELLDLLSSWPSLRELDLTG 177
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 5-208 1.73e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 55.62  E-value: 1.73e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351522   5 LKRLTILSLKSNNLT-RIPPNLS*--TLKELYI-YNNMIEEIQDQdLSGLPNLEILDLsgncprCYNAPYPCIPcpkssi 80
Cdd:PLN00113 187 LTSLEFLTLASNQLVgQIPRELGQmkSLKWIYLgYNNLSGEIPYE-IGGLTSLNHLDL------VYNNLTGPIP------ 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351522  81 qihsAAFDSLENLRVLRLHSNSLQ-SVPSSWFkNIRNLKELDLSQNFLMREIGD--AQFLTFipSLVHLdLSFNFQLKmy 157
Cdd:PLN00113 254 ----SSLGNLKNLQYLFLYQNKLSgPIPPSIF-SLQKLISLDLSDNSLSGEIPElvIQLQNL--EILHL-FSNNFTGK-- 323

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 514351522 158 spflnLSKTFSSLSNLETL-----RLKGYVFKELRAQDlhpllslrNLTMLDLGTN 208
Cdd:PLN00113 324 -----IPVALTSLPRLQVLqlwsnKFSGEIPKNLGKHN--------NLTVLDLSTN 366
LRR_8 pfam13855
Leucine rich repeat;
92-151 3.74e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 3.74e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351522   92 NLRVLRLHSNSLQSVPSSWFKNIRNLKELDLSQNfLMREIGDAQFlTFIPSLVHLDLSFN 151
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNN-LLTTLSPGAF-SGLPSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
7-61 2.89e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.75  E-value: 2.89e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 514351522    7 RLTILSLKSNNLTRIPP----NLS*tLKELYIYNNMIEEIQDQDLSGLPNLEILDLSGN 61
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDgafkGLSN-LKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR_12 pfam18837
Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the ...
 200-229 4.20e-07

Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the pfam00560 model. This entry represents one repeat unit.


Pssm-ID: 408607  Cd Length: 30  Bit Score: 45.41  E-value: 4.20e-07
                          10        20        30
                  ....*....|....*....|....*....|
gi 514351522  200 LTMLDLGTNFIKVADLTVFEKFPALKFIDL 229
Cdd:pfam18837   1 LQTLHLQMNFINQAQLSIFGAFPGLRFVDL 30
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 8-210 1.64e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.46  E-value: 1.64e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351522   8 LTILSLKSNNLT-RIPPNLS*TLKELYIYNNMIEEIQDQDLSGLPNLEILDLSGncprcyNAPYPCIPcpkssiqihsAA 86
Cdd:PLN00113 120 LRYLNLSNNNFTgSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGG------NVLVGKIP----------NS 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351522  87 FDSLENLRVLRLHSNSLQSVPSSWFKNIRNLKELDLSQNFLMREIGDAqfLTFIPSLVHLDLSFNfqlkmyspflNLSKT 166
Cdd:PLN00113 184 LTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYE--IGGLTSLNHLDLVYN----------NLTGP 251

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 514351522 167 F-SSLSNLETLRlkgYVF---KELRAQDLHPLLSLRNLTMLDLGTNFI 210
Cdd:PLN00113 252 IpSSLGNLKNLQ---YLFlyqNKLSGPIPPSIFSLQKLISLDLSDNSL 296
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 5-151 3.44e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.09  E-value: 3.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351522   5 LKRLTILSLKSNNLTRIpPNLS--*TLKELYIYNNMIEEIqdQDLSGLPNLEILDLSGNCPRcynapypcipcPKSSIQI 82
Cdd:cd21340   45 LTNLTHLYLQNNQIEKI-ENLEnlVNLKKLYLGGNRISVV--EGLENLTNLEELHIENQRLP-----------PGEKLTF 110

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 514351522  83 HSAAFDSL-ENLRVLRLHSNSLQSVpsSWFKNIRNLKELDLSQNFL--MREIgdAQFLTFIPSLVHLDLSFN 151
Cdd:cd21340  111 DPRSLAALsNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQIsdLEEL--LDLLSSWPSLRELDLTGN 178
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 8-235 1.17e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 46.76  E-value: 1.17e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351522   8 LTILSLKSNNLT-RIPPNL--S*TLKELYIYNNMIEEIQDQDLSGLPNLEILDL-----SGNCPRcynapypcipcpkss 79
Cdd:PLN00113 358 LTVLDLSTNNLTgEIPEGLcsSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLqdnsfSGELPS--------------- 422

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351522  80 iqihsaAFDSLENLRVLRLHSNSLQSVPSSWFKNIRNLKELDLSQNFLMREIGDaqfLTFIPSLVHLDLSFNfQLKMYSP 159
Cdd:PLN00113 423 ------EFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLPD---SFGSKRLENLDLSRN-QFSGAVP 492

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 514351522 160 flnlsKTFSSLSNLETLRLKGyvfKELRAQDLHPLLSLRNLTMLDLGTNFIKVADLTVFEKFPALKFIDLSVNKIS 235
Cdd:PLN00113 493 -----RKLGSLSELMQLKLSE---NKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLS 560
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 88-235 1.23e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.81  E-value: 1.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351522  88 DSLENLRVLRLHSNSLQSVP----SSWFKNIRNLKELDLSQNflmrEIGD------AQFLTFIPSLVHLDLSFNFqlkmy 157
Cdd:cd00116  134 DLPPALEKLVLGRNRLEGAScealAKALRANRDLKELNLANN----GIGDagiralAEGLKANCNLEVLDLNNNG----- 204

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351522 158 spfLN------LSKTFSSLSNLETLRLKGYVFKELRAQDLHPLLSLRNLTM--LDLGTNFIK----VADLTVFEKFPALK 225
Cdd:cd00116  205 ---LTdegasaLAETLASLKSLEVLNLGDNNLTDAGAAALASALLSPNISLltLSLSCNDITddgaKDLAEVLAEKESLL 281

                        170
                 ....*....|
gi 514351522 226 FIDLSVNKIS 235
Cdd:cd00116  282 ELDLRGNKFG 291
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
6-127 2.28e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 45.84  E-value: 2.28e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351522   6 KRLTILSLKSNNLTRIPPNLS*TLKELYIYNNMIEEIQDQdlsgLPN-LEILDLSGNcpRCYNAPYPcIPCPKSSIQIHS 84
Cdd:PRK15370 199 EQITTLILDNNELKSLPENLQGNIKTLYANSNQLTSIPAT----LPDtIQEMELSIN--RITELPER-LPSALQSLDLFH 271

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 514351522  85 AAFDSL-----ENLRVLRLHSNSLQSVPSSWFKNIRNLKELDLSQNFL 127
Cdd:PRK15370 272 NKISCLpenlpEELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTAL 319
LRR_8 pfam13855
Leucine rich repeat;
51-125 3.50e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.97  E-value: 3.50e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 514351522   51 PNLEILDLSGNcprcynapypcipcpksSIQ-IHSAAFDSLENLRVLRLHSNSLQSVPSSWFKNIRNLKELDLSQN 125
Cdd:pfam13855   1 PNLRSLDLSNN-----------------RLTsLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
28-103 1.76e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.66  E-value: 1.76e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 514351522   28 TLKELYIYNNMIEEIQDQDLSGLPNLEILDLSGNCPRCynapypcipcpkssiqIHSAAFDSLENLRVLRLHSNSL 103
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT----------------LSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 28-151 2.12e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 42.34  E-value: 2.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351522  28 TLKELYIYNNMIEE--IQD--QDLSGLPNLEILDLSGNCPRCYNApypcipcpkssiQIHSAAFDSLENLRVLRLHSNSL 103
Cdd:cd00116  166 DLKELNLANNGIGDagIRAlaEGLKANCNLEVLDLNNNGLTDEGA------------SALAETLASLKSLEVLNLGDNNL 233

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 514351522 104 QSVPSSWFKNI-----RNLKELDLSQNflmrEIGDAQFLTFI------PSLVHLDLSFN 151
Cdd:cd00116  234 TDAGAAALASAllspnISLLTLSLSCN----DITDDGAKDLAevlaekESLLELDLRGN 288
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 87-235 1.98e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.61  E-value: 1.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351522  87 FDSLENLRVLRLHSNSLQSVPSswFKNIRNLKELDLSQNFLmREIGDAQFLtfiPSLVHLDLSFNfqlkmyspflNLSKT 166
Cdd:cd21340   20 LSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQI-EKIENLENL---VNLKKLYLGGN----------RISVV 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351522 167 --FSSLSNLETLRLKGyvfkelraQDLHP----------LLSLRN-LTMLDLGTNfiKVADLTVFEKFPALKFIDLSVNK 233
Cdd:cd21340   84 egLENLTNLEELHIEN--------QRLPPgekltfdprsLAALSNsLRVLNISGN--NIDSLEPLAPLRNLEQLDASNNQ 153


                 ..
gi 514351522 234 IS 235
Cdd:cd21340  154 IS 155
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 29-61 2.71e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.91  E-value: 2.71e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 514351522   29 LKELYIYNNMIEEIQDqdLSGLPNLEILDLSGN 61
Cdd:pfam12799   3 LEVLDLSNNQITDIPP--LAKLPNLETLDLSGN 33
LRR_9 pfam14580
Leucine-rich repeat;
5-61 2.84e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 37.82  E-value: 2.84e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 514351522    5 LKRLTILSLKSNNLTRIPPNLS*---TLKELYIYNNMIEEIQDQD-LSGLPNLEILDLSGN 61
Cdd:pfam14580  63 LRRLKTLLLNNNRICRIGEGLGEalpNLTELILTNNNLQELGDLDpLASLKKLTFLSLLRN 123
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 49-238 3.25e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.06  E-value: 3.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351522  49 GLPNLEILDLSGNcprcynapypcipcpKSSIQIHSAAFDSLENLRVLRLHSNSLQ-SVPSSwfkNIRNLKELDLSQNFL 127
Cdd:PLN00113  91 RLPYIQTINLSNN---------------QLSGPIPDDIFTTSSSLRYLNLSNNNFTgSIPRG---SIPNLETLDLSNNML 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514351522 128 MREIgdAQFLTFIPSLVHLDLSFNFQlkmyspflnLSKTFSSLSNLETLRLKGYVFKELRAQDLHPLLSLRNLTMLDLGT 207
Cdd:PLN00113 153 SGEI--PNDIGSFSSLKVLDLGGNVL---------VGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGY 221

                        170       180       190
                 ....*....|....*....|....*....|....
gi 514351522 208 NFIKVADLTVFEKFPALKFIDLSVNKIS---PSS 238
Cdd:PLN00113 222 NNLSGEIPYEIGGLTSLNHLDLVYNNLTgpiPSS 255
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 92-133 4.53e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.53  E-value: 4.53e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 514351522   92 NLRVLRLHSNSLQSVPSswFKNIRNLKELDLSQNFLMREIGD 133
Cdd:pfam12799   2 NLEVLDLSNNQITDIPP--LAKLPNLETLDLSGNNKITDLSD 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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