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Conserved domains on  [gi|558550277|gb|AHA61730|]
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DhfrII [Cloning vector pTn5.7luxT5]

Protein Classification

similar to dihydrofolate reductase type( domain architecture ID 10534194)

protein similar to dihydrofolate reductase type

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DHFR_2 pfam06442
R67 dihydrofolate reductase; R67 dihydrofolate reductase is a plasmid encoded enzyme that ...
 1-78 1.65e-53

R67 dihydrofolate reductase; R67 dihydrofolate reductase is a plasmid encoded enzyme that provides resistance to the antibacterial drug trimethoprim. The R67 dihydrofolate reductase does not share significant similarity to the chromosomal encoded dihydrofolate reductase.


:

Pssm-ID: 368910  Cd Length: 78  Bit Score: 160.21  E-value: 1.65e-53
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 558550277   1 MGQSSDEANAPVAGQFALPLSATFGLGDRVRKKSGAAWQGQVVGWYCTKLTPEGYAVESESHPGSVQIYPVAALERVA 78
Cdd:pfam06442  1 MNESSNEVSTPVAGRFAFPSNATFGLGDRVRKKSGAAWQGQIVGWYCTTLTPEGYAVESESHPGSVQIYPVAALERVA 78
 
Name Accession Description Interval E-value
DHFR_2 pfam06442
R67 dihydrofolate reductase; R67 dihydrofolate reductase is a plasmid encoded enzyme that ...
 1-78 1.65e-53

R67 dihydrofolate reductase; R67 dihydrofolate reductase is a plasmid encoded enzyme that provides resistance to the antibacterial drug trimethoprim. The R67 dihydrofolate reductase does not share significant similarity to the chromosomal encoded dihydrofolate reductase.


Pssm-ID: 368910  Cd Length: 78  Bit Score: 160.21  E-value: 1.65e-53
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 558550277   1 MGQSSDEANAPVAGQFALPLSATFGLGDRVRKKSGAAWQGQVVGWYCTKLTPEGYAVESESHPGSVQIYPVAALERVA 78
Cdd:pfam06442  1 MNESSNEVSTPVAGRFAFPSNATFGLGDRVRKKSGAAWQGQIVGWYCTTLTPEGYAVESESHPGSVQIYPVAALERVA 78
 
Name Accession Description Interval E-value
DHFR_2 pfam06442
R67 dihydrofolate reductase; R67 dihydrofolate reductase is a plasmid encoded enzyme that ...
 1-78 1.65e-53

R67 dihydrofolate reductase; R67 dihydrofolate reductase is a plasmid encoded enzyme that provides resistance to the antibacterial drug trimethoprim. The R67 dihydrofolate reductase does not share significant similarity to the chromosomal encoded dihydrofolate reductase.


Pssm-ID: 368910  Cd Length: 78  Bit Score: 160.21  E-value: 1.65e-53
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 558550277   1 MGQSSDEANAPVAGQFALPLSATFGLGDRVRKKSGAAWQGQVVGWYCTKLTPEGYAVESESHPGSVQIYPVAALERVA 78
Cdd:pfam06442  1 MNESSNEVSTPVAGRFAFPSNATFGLGDRVRKKSGAAWQGQIVGWYCTTLTPEGYAVESESHPGSVQIYPVAALERVA 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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