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Conserved domains on  [gi|661915554|gb|AIE38915|]
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vomeronasal 1 receptor, partial [Microcebus murinus]

Protein Classification

G protein-coupled receptor family protein( domain architecture ID 705710)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tm_GPCRs super family cl28897
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
1-225 1.19e-62

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


The actual alignment was detected with superfamily member cd13949:

Pssm-ID: 475119  Cd Length: 295  Bit Score: 197.11  E-value: 1.19e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661915554   1 LVLCCKGVPQTLAAFGlEAFLDEAGCKLVFYLHRVARGVSLSTTCLLSGFQAIKLCPSISRWMDPHIRSPKCIVLCCFLC 80
Cdd:cd13949   51 LLLLTMGIIATDAFFS-WGGWDDITCKFLIYLHRVLRGLSLCTTCLLSVLQAITLSPRSSCLAKFKHKSPHHISGAFLFL 129
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661915554  81 WVLHLVVNIYIARYATGSINRKNKTMDKIYLYCSTPIPGRLVFSVTAVIFLFTDALCLALMVWTSSSMVLVLHRHKQRVQ 160
Cdd:cd13949  130 WVLYMLISSHLLVSIIATPNLTSNNFIYVTQSCSILPMSYSMQSLFSTLLAFRDVFLIGLMLLSSGYMVALLHRHKKQVQ 209
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 661915554 161 HIRSSRLSPRTSHETRATHTILILVSMFVSSHALAAILSYWIIRLQNPSQWLRSISVLVASGFPT 225
Cdd:cd13949  210 HLHSTSLSPKASPEQRATQTILLLMSFFVVMYILDSIVFYSRTKFKNDSILYCVQIIVSHSYATV 274
 
Name Accession Description Interval E-value
7tm_V1R_pheromone cd13949
vomeronasal organ pheromone receptor type-1 family, member of the seven-transmembrane G ...
1-225 1.19e-62

vomeronasal organ pheromone receptor type-1 family, member of the seven-transmembrane G protein-coupled receptor superfamily; This family represents vomeronasal type-1 receptors (V1Rs) that are specifically expressed in the vomeronasal organ (VNO), which is the sensory organ of the accessory olfactory system present in amphibians, reptiles, and non-primate mammals such as mice and rodents, but it is non-functional or absent in humans, apes and monkeys. The VNO detects pheromones, chemicals released from animals that can influence social and reproductive behaviors, such as male-male aggression or sexual mating, in other members of the same species. On the other hand, the olfactory epithelium, which contains olfactory receptor neurons inside the nasal cavity, is responsible for detecting odor molecules (smells). There are two types of vertebrate pheromones: (1) small volatile molecules such as 2-heptanone, a substance in the urine of both male and female that extends estrous cycle length in female mice; and (2) water-soluble molecules such as the major histocompatibility complex (HMC) class-I peptide, which can induce the pregnancy block effect, the tendency for female rodents to abort their pregnancies upon exposure to the scent of an unknown male. While V1Rs and G-alpha(i2) protein are co-expressed in the apical neurons of the VNO, V2Rs (type-2 vomeronasal receptors) and G-alpha(o) protein are coexpressed in the basal layer of the VNO. Activation of V1R or V2R causes stimulation of phospholipase pathway, generating diacylglycerol (DAG) and inositol 1,4,5-triphosphate (IP3). V1Rs have a short N-terminal extracellular domain, whereas V2Rs contain a long N-terminal extracellular domain, which is believed to bind pheromones. Although V1Rs share the seven-transmembrane domain structure with V1Rs and olfactory receptors, they share little sequence similarity with each other.


Pssm-ID: 320087  Cd Length: 295  Bit Score: 197.11  E-value: 1.19e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661915554   1 LVLCCKGVPQTLAAFGlEAFLDEAGCKLVFYLHRVARGVSLSTTCLLSGFQAIKLCPSISRWMDPHIRSPKCIVLCCFLC 80
Cdd:cd13949   51 LLLLTMGIIATDAFFS-WGGWDDITCKFLIYLHRVLRGLSLCTTCLLSVLQAITLSPRSSCLAKFKHKSPHHISGAFLFL 129
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661915554  81 WVLHLVVNIYIARYATGSINRKNKTMDKIYLYCSTPIPGRLVFSVTAVIFLFTDALCLALMVWTSSSMVLVLHRHKQRVQ 160
Cdd:cd13949  130 WVLYMLISSHLLVSIIATPNLTSNNFIYVTQSCSILPMSYSMQSLFSTLLAFRDVFLIGLMLLSSGYMVALLHRHKKQVQ 209
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 661915554 161 HIRSSRLSPRTSHETRATHTILILVSMFVSSHALAAILSYWIIRLQNPSQWLRSISVLVASGFPT 225
Cdd:cd13949  210 HLHSTSLSPKASPEQRATQTILLLMSFFVVMYILDSIVFYSRTKFKNDSILYCVQIIVSHSYATV 274
V1R pfam03402
Vomeronasal organ pheromone receptor family, V1R; This family represents one of two known ...
1-225 2.24e-61

Vomeronasal organ pheromone receptor family, V1R; This family represents one of two known vomeronasal organ receptor families, the V1R family.


Pssm-ID: 460912  Cd Length: 292  Bit Score: 193.71  E-value: 2.24e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661915554    1 LVLCCKGVpQTLAAFGLEAFLDEAGCKLVFYLHRVARGVSLSTTCLLSGFQAIKLCPSISRWMDPHIRSPKCIVLCCFLC 80
Cdd:pfam03402  51 LMLLTMGI-IAMDAFGSQGRWDDTTCKFLIYLHRVLRGLSLCTTCLLSVLQAITLSPRSSCLAKFKHKSPHHISGAFLFL 129
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661915554   81 WVLHLVVNIYIARYATGSINRKNKTMDKIYLYCSTPIPGRLVFSVTAVIFLFTDALCLALMVWTSSSMVLVLHRHKQRVQ 160
Cdd:pfam03402 130 WVLYMSISSHLLLSIIATPNLTSSSFIYVTQSCSILPMSYSMQSLFSTLLASRDVFLIGLMVLSSGYMVALLCRHKKQAQ 209
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 661915554  161 HIRSSRLSPRTSHETRATHTILILVSMFVSSHALAAILSYWIIRLQNPSqWLRSISVLVASGFPT 225
Cdd:pfam03402 210 HLHGTSLSPKASPEQRATRTILLLMSFFVVMYILDSIVSYSRTMFKNDS-IFYCVQILVSHSYAT 273
 
Name Accession Description Interval E-value
7tm_V1R_pheromone cd13949
vomeronasal organ pheromone receptor type-1 family, member of the seven-transmembrane G ...
1-225 1.19e-62

vomeronasal organ pheromone receptor type-1 family, member of the seven-transmembrane G protein-coupled receptor superfamily; This family represents vomeronasal type-1 receptors (V1Rs) that are specifically expressed in the vomeronasal organ (VNO), which is the sensory organ of the accessory olfactory system present in amphibians, reptiles, and non-primate mammals such as mice and rodents, but it is non-functional or absent in humans, apes and monkeys. The VNO detects pheromones, chemicals released from animals that can influence social and reproductive behaviors, such as male-male aggression or sexual mating, in other members of the same species. On the other hand, the olfactory epithelium, which contains olfactory receptor neurons inside the nasal cavity, is responsible for detecting odor molecules (smells). There are two types of vertebrate pheromones: (1) small volatile molecules such as 2-heptanone, a substance in the urine of both male and female that extends estrous cycle length in female mice; and (2) water-soluble molecules such as the major histocompatibility complex (HMC) class-I peptide, which can induce the pregnancy block effect, the tendency for female rodents to abort their pregnancies upon exposure to the scent of an unknown male. While V1Rs and G-alpha(i2) protein are co-expressed in the apical neurons of the VNO, V2Rs (type-2 vomeronasal receptors) and G-alpha(o) protein are coexpressed in the basal layer of the VNO. Activation of V1R or V2R causes stimulation of phospholipase pathway, generating diacylglycerol (DAG) and inositol 1,4,5-triphosphate (IP3). V1Rs have a short N-terminal extracellular domain, whereas V2Rs contain a long N-terminal extracellular domain, which is believed to bind pheromones. Although V1Rs share the seven-transmembrane domain structure with V1Rs and olfactory receptors, they share little sequence similarity with each other.


Pssm-ID: 320087  Cd Length: 295  Bit Score: 197.11  E-value: 1.19e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661915554   1 LVLCCKGVPQTLAAFGlEAFLDEAGCKLVFYLHRVARGVSLSTTCLLSGFQAIKLCPSISRWMDPHIRSPKCIVLCCFLC 80
Cdd:cd13949   51 LLLLTMGIIATDAFFS-WGGWDDITCKFLIYLHRVLRGLSLCTTCLLSVLQAITLSPRSSCLAKFKHKSPHHISGAFLFL 129
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661915554  81 WVLHLVVNIYIARYATGSINRKNKTMDKIYLYCSTPIPGRLVFSVTAVIFLFTDALCLALMVWTSSSMVLVLHRHKQRVQ 160
Cdd:cd13949  130 WVLYMLISSHLLVSIIATPNLTSNNFIYVTQSCSILPMSYSMQSLFSTLLAFRDVFLIGLMLLSSGYMVALLHRHKKQVQ 209
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 661915554 161 HIRSSRLSPRTSHETRATHTILILVSMFVSSHALAAILSYWIIRLQNPSQWLRSISVLVASGFPT 225
Cdd:cd13949  210 HLHSTSLSPKASPEQRATQTILLLMSFFVVMYILDSIVFYSRTKFKNDSILYCVQIIVSHSYATV 274
V1R pfam03402
Vomeronasal organ pheromone receptor family, V1R; This family represents one of two known ...
1-225 2.24e-61

Vomeronasal organ pheromone receptor family, V1R; This family represents one of two known vomeronasal organ receptor families, the V1R family.


Pssm-ID: 460912  Cd Length: 292  Bit Score: 193.71  E-value: 2.24e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661915554    1 LVLCCKGVpQTLAAFGLEAFLDEAGCKLVFYLHRVARGVSLSTTCLLSGFQAIKLCPSISRWMDPHIRSPKCIVLCCFLC 80
Cdd:pfam03402  51 LMLLTMGI-IAMDAFGSQGRWDDTTCKFLIYLHRVLRGLSLCTTCLLSVLQAITLSPRSSCLAKFKHKSPHHISGAFLFL 129
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661915554   81 WVLHLVVNIYIARYATGSINRKNKTMDKIYLYCSTPIPGRLVFSVTAVIFLFTDALCLALMVWTSSSMVLVLHRHKQRVQ 160
Cdd:pfam03402 130 WVLYMSISSHLLLSIIATPNLTSSSFIYVTQSCSILPMSYSMQSLFSTLLASRDVFLIGLMVLSSGYMVALLCRHKKQAQ 209
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 661915554  161 HIRSSRLSPRTSHETRATHTILILVSMFVSSHALAAILSYWIIRLQNPSqWLRSISVLVASGFPT 225
Cdd:pfam03402 210 HLHGTSLSPKASPEQRATRTILLLMSFFVVMYILDSIVSYSRTMFKNDS-IFYCVQILVSHSYAT 273
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
1-220 3.19e-10

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 58.21  E-value: 3.19e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661915554   1 LVLCCKGVPQTLAAFGLEAFLDEAGCKLVFYLHRVARGVSLSTTCLLSGFQAIKLCpsiSRWMDPHIRSPKCIVLCCFLC 80
Cdd:cd14964   46 LASLVVLVLFFLLGLTEASSRPQALCYLIYLLWYGANLASIWTTLVLTYHRYFALC---GPLKYTRLSSPGKTRVIILGC 122
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661915554  81 WVLHLVVNIYIARYATGSINRKNKTMDKiylycstpipgRLVFSVTAVIFLFTDALCLALMVWTSSSMVLVLHRHKQRVQ 160
Cdd:cd14964  123 WGVSLLLSIPPLVGKGAIPRYNTLTGSC-----------YLICTTIYLTWGFLLVSFLLPLVAFLVIFSRIVLRLRRRVR 191
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 661915554 161 HIRsSRLSPRTSHETRATHTILILVSMFVSSHALAAIlsYWIIRLQNPSQWLRSISVLVA 220
Cdd:cd14964  192 AIR-SAASLNTDKNLKATKSLLILVITFLLCWLPFSI--VFILHALVAAGQGLNLLSILA 248
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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