|
Name |
Accession |
Description |
Interval |
E-value |
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
43-868 |
0e+00 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 799.02 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 43 MGTPKIPEKRWSIDLEKKIQEsHYAEtySKRYSFDPKSEREIFIIDTPPPYPSGTWHIGAVAQYSMIDVIARSQRLLGKE 122
Cdd:PRK13208 1 KMMPELPKKYDPEELEEKWQK-IWEE--EGTYKFDPDERKPVYSIDTPPPTVSGSLHIGHVFSYTHTDFIARYQRMRGYN 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 123 VRFPWGVDRNGINIEFTVERKHGRKMRSYERGEFLDLCSETIESYTQAMRDTAKRVGLSCDFDNEYLTDAPDYRAVTQSI 202
Cdd:PRK13208 78 VFFPQGWDDNGLPTERKVEKYYGIRKDDISREEFIELCRELTDEDEKKFRELWRRLGLSVDWSLEYQTISPEYRRISQKS 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 203 FVDLFKRGDIVEDLRPNIYDPVEGTSIAEAEVQRITRETLLCDVRWTTEDGEDVEISTTRPEMICACGVVVVHPDDQRYS 282
Cdd:PRK13208 158 FLDLYKKGLIYRAEAPVLWCPRCETAIAQAEVEYREREGKLNYIKFPVEDGEEIEIATTRPELLPACVAVVVHPDDERYK 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 283 HLVGKRVQLpmPVADREpsVEIITHPSVKMDFGSGVLMVCSFGDQNDVAVFRELGLKPFVAVDLDGRMTGISGPLIGMSA 362
Cdd:PRK13208 238 HLVGKTAIV--PLFGVE--VPILADPLVDPDFGTGAVMICTFGDKTDVTWWRELNLPTRIIIDEDGRMTEAAGKLAGLTI 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 363 ENARAASIEILNESGRLTTTEKHMQEVPVSERGGNPVEIILLKEWYVRQTHILERLSELSDQSSFIPERNRQFLHDWMDG 442
Cdd:PRK13208 314 EEARKKIVEDLKSGGLLGKQEPIKHNVKFCERCDTPLEILVTRQWFIKVLDLKEELLERGKEINWYPEHMRVRLENWIEG 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 443 ISIDWPISRRRWYHTEVPIWYSEDGSRVVVPPHGAY-VQPWRTKPPHgsevldrETREHLGSyqdladslGDLVGEEKVF 521
Cdd:PRK13208 394 LNWDWCISRQRYFGTPIPVWYCKDCGHPILPDEEDLpVDPTKDEPPG-------YKCPQCGS--------PGFEGETDVM 458
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 522 DTWMDSSNSNLYVSGYISDPELFRRAFPTSIRPQGKEIVRTWLYYTLLKSALLLDKPGFQNIWVDGLGMDPWGRKMSKSL 601
Cdd:PRK13208 459 DTWATSSITPLIVTGWERDEDLFEKVFPMDLRPQGHDIIRTWLFYTILRAYLLTGKLPWKNIMISGMVLDPDGKKMSKSK 538
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 602 GNGIDADSVLEcgaggrtgswrikgpdgkqiqlranKIGSECFRLWKAcDAQVGDDFHINPEEIESKY-FgvLTKLFNVA 680
Cdd:PRK13208 539 GNVVTPEELLE-------------------------KYGADAVRYWAA-SARLGSDTPFDEKQVKIGRrL--LTKLWNAS 590
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 681 RFASQFDVPGDLDDSPSgLPPEDLWILSEFGAVMEQVEGAWMDIDIYTAAQSLKGFGTGVFPSHWLEMSKSRLYDGD--- 757
Cdd:PRK13208 591 RFVLHFSADPEPDKAEV-LEPLDRWILAKLAKVVEKATEALENYDFAKALEEIESFFWHVFCDDYLELVKSRAYGEDeee 669
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 758 --DSATWTLHRVVRDLLSTMSPICPFFCHYLSTTLYGSSaVDVRSFprlPELMAPEDATYMRSLTPIISEFNSEVWKAKK 835
Cdd:PRK13208 670 eqKSARYTLYTVLDTLLRLLAPFLPFITEEVWSWLYGGS-VHRASW---PEPDEELIDEEDEELGELAKEILSAVRKYKS 745
|
810 820 830
....*....|....*....|....*....|....*...
gi 663501384 836 DSGLSLKSPIS-----GISIPSELSELRESLVRMHSIE 868
Cdd:PRK13208 746 EAGLSLNAPLKkvevyGPADLELLEAAEEDLKAAGNIE 783
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
48-853 |
2.48e-151 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 466.46 E-value: 2.48e-151
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 48 IPEKRWSIDLEKKIQEsHYAEtySKRYSFDPKSEREIFIIDTPPPYPSGTWHIGAVAQYSMIDVIARSQRLLGKEVRFPW 127
Cdd:TIGR00422 1 MPKDYDPHEVEKKWYK-KWEK--SGFFKPDGNSNKPPFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWLP 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 128 GVDRNGINIEFTVERKHGRKMRS---YERGEFLDLCSETIESYTQAMRDTAKRVGLSCDFDNEYLTDAPDYRAVTQSIFV 204
Cdd:TIGR00422 78 GTDHAGIATQVKVEKKLGAEGKTkhdLGREEFREKIWEWKEESGGTIKNQIKRLGASLDWSRERFTMDEGLSKAVKEAFV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 205 DLFKRGDIVEDLRPNIYDPVEGTSIAEAEVQRITRETLLCDVRWTTEDG--EDVEISTTRPEMICACGVVVVHPDDQRYS 282
Cdd:TIGR00422 158 RLYEKGLIYRGEYLVNWDPKLNTAISDIEVEYKEVKGKLYYIRYPLANGskDYLVVATTRPETMFGDTAVAVHPEDERYK 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 283 HLVGKRVQLPMpvADREpsVEIITHPSVKMDFGSGVLMVCSFGDQNDVAVFRELGLkPFV-AVDLDGRMTGISGPLIGMS 361
Cdd:TIGR00422 238 HLIGKKVILPL--TGRK--IPIIADEYVDMEFGTGAVKVTPAHDFNDYEWGKRHNL-EFInILDEDGLLNENAGKYQGLT 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 362 AENARAASIEILNESGRLTTTEKHMQEVPVSERGGNPVEIILLKEWYVRQTHILERLSELSDQSS--FIPERNRQFLHDW 439
Cdd:TIGR00422 313 RFEARKKIVEDLKEEGLLVKIEPHTHNVGTCWRSGTVVEPLLSKQWFVKVEKLADKALEAAEEGEikFVPKRMEKRYLNW 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 440 MDGISiDWPISRRRWYHTEVPIWYSEDGSRVVVPphgayvqpwRTKPPhgsevLDRETREhlgsyqdlaDSLGDLVGEEK 519
Cdd:TIGR00422 393 LRNIK-DWCISRQLIWGHRIPVWYCKECGEVYVA---------KEEPL-----PDDKTNT---------GPSVELEQDTD 448
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 520 VFDTWMDSSNSNLYVSGYISDPELFRRAFPTSIRPQGKEIVRTWLYYTLLKSALLLDKPGFQNIWVDGLGMDPWGRKMSK 599
Cdd:TIGR00422 449 VLDTWFSSSLWPFSTLGWPDETKDLKKFYPTDLLVTGYDIIFFWVARMIFRSLALTGQVPFKEVYIHGLVRDEQGRKMSK 528
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 600 SLGNGIDADSVLEcgaggrtgswrikgpdgkqiqlranKIGSECFRLWKACDAQVGDDFHINPEEIESkYFGVLTKLFNV 679
Cdd:TIGR00422 529 SLGNVIDPLDVIE-------------------------KYGADALRFTLASLVTPGDDINFDWKRVES-ARNFLNKLWNA 582
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 680 ARFASQfDVPGDLDDSPSGLP--PEDLWILSEFGAVMEQVEGAWMDIDIYTAAQSLKGFGTGVFPSHWLEMSKSRLYDGD 757
Cdd:TIGR00422 583 SRFVLM-NLSDDLELSGGEEKlsLADRWILSKLNRTIKEVRKALDKYRFAEAAKALYEFIWNDFCDWYIELVKYRLYNGN 661
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 758 D----SATWTLHRVVRDLLSTMSPICPFFCHYLSTTLY-GSSAVDVRSFPR-LPELMAPEDATymrsLTPIISEFNSEVW 831
Cdd:TIGR00422 662 EaekkAARDTLYYVLDKALRLLHPFMPFITEEIWQHFKeGADSIMLQSYPVvDAEFVDEEAEK----AFELLKEIIVSIR 737
|
810 820
....*....|....*....|..
gi 663501384 832 KAKKDSGLSLKSPISGISIPSE 853
Cdd:TIGR00422 738 NLKAESNIPPNAPLKVLLIYTE 759
|
|
| alt_ValS |
NF000540 |
valine--tRNA ligase; |
74-861 |
4.65e-118 |
|
valine--tRNA ligase;
Pssm-ID: 467949 [Multi-domain] Cd Length: 827 Bit Score: 378.11 E-value: 4.65e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 74 YSFDPKSERE-IFIIDTPPPYPSGTWHIGAVAQYSMIDVIARSQRLLGKEVRFPWGVDRNGINIEFTVERKHG------- 145
Cdd:NF000540 23 YAFDRPAAREeVFSIDTPPPTVSGSLHVGHVFSYTHTDVVARYQRMRGKEVFYPMGWDDNGLPTERRVQNYYGvrcdpsl 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 146 --------------RKMRSYERGEFLDLCSETIESYTQAMRDTAKRVGLSCDFDNEYLTDAPDYRAVTQSIFVDLFKRGD 211
Cdd:NF000540 103 pydpdftppekpgpKDQVPISRRNFIELCERLTAEDEKAFEDLWRRLGLSVDWSLTYRTIGDRARRVSQRAFLRNLARGE 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 212 IVEDLRPNIYDPVEGTSIAEAEVQRITRETLLCDVRWTTEDGEDVEISTTRPEMICACGVVVVHPDDQRYSHLVGKRVQl 291
Cdd:NF000540 183 AYQAEAPTLWDVTFQTAVAQAELEDREYPGAYHRLAFHGADGGPVHIETTRPELLPACVALVAHPDDERYQPLFGTTVT- 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 292 pMPVADREpsVEIITHPSVKMDFGSGVLMVCSFGDQNDVAVFRELGLKPFVAVDLDGRMT-----GISGP--------LI 358
Cdd:NF000540 262 -SPLFGVE--VPVLAHPLAEPDKGSGIAMCCTFGDLTDVTWWRELQLPTRAIIGRDGRLLaetpeWITSEagraayaeLA 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 359 GMSAENARAASIEILNESGRLTTTEKHMQEvPVS--ERGGNPVEIILLKEWYVR--------QTHILERLSELSdqssFI 428
Cdd:NF000540 339 GKTVFSAREAVVELLRESGDLDGEPRPIQH-PVKfyEKGDKPLEIVSTRQWYIRnggrdadlREALLARGRELA----WH 413
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 429 PERNRQFLHDWMDGISIDWPISRRRWYHTEVPIWYSEDG------SRVVVPPHGAY-VQPWRTKPPHGSEvldretrehl 501
Cdd:NF000540 414 PEHMRVRYENWVEGLNGDWLISRQRFFGVPFPVWYPLDAdgepdyDAPIVPAEDQLpVDPSSDVPPGYTE---------- 483
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 502 gsyqDLADSLGDLVGEEKVFDTWMDSSNSNLYVSGYISDPELFRRAFPTSIRPQGKEIVRTWLYYTLLKSALLLDKPGFQ 581
Cdd:NF000540 484 ----DQRGVPGGFIGDPDVMDTWATSSLTPQIAGGWERDPDLFARVFPMDLRPQGHDIIRTWLFSTVVRAHLEHGSLPWR 559
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 582 NIWVDGLGMDPWGRKMSKSLGNGIDADSVLEcgaggrtgswrikgpdgkqiqlranKIGSECFRLWkACDAQVGDDFHIN 661
Cdd:NF000540 560 HAAISGWILDPDRKKMSKSKGNVVTPTGLLE-------------------------QHGSDAVRYW-AASARPGTDTAFD 613
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 662 PEEIEskyFG--VLTKLFNVARFASQFDVPGDLDDSPSglPPEDLWILSEFGAVMEQVEGAWMDIDiYTAA--QSLKGFG 737
Cdd:NF000540 614 ETQMK---VGrrLAIKLLNASKFVLGFGAPAGDPAAVT--EPLDRAMLAALAEVVEQATAAFEAYD-YTRAleVTESFFW 687
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 738 TgvFPSHWLEMSKSRLYDGD-----DSATWTLHRVVRDLLSTMSPICPFFCHYL-STTLYGSsaVDVRSFPRLPELMAPE 811
Cdd:NF000540 688 T--FCDDYLELVKERAYGADgeaaaASARAALATALSVLLRLFAPFLPFATEEVwSWWQEGS--VHRAAWPTADELELPA 763
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|...
gi 663501384 812 DATymRSLTPIISEFNSEVWKAKKDSGLSLKSPISGISI---PSELSELRESL 861
Cdd:NF000540 764 DGD--PALLALASAALAGIRKAKSEAKVSMRTPVARATVtgpAAQLALLEAAE 814
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
75-615 |
2.27e-96 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 314.35 E-value: 2.27e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 75 SFDPKSEREIFIIDTPPPYPSGTWHIGAVAQYSMIDVIARSQRLLGKEVRFPWGVDRNGINIEFTVERKHGRKMR----S 150
Cdd:pfam00133 15 ELEKRKGKPSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQVVEKKLGIKEKktrhK 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 151 YERGEFLDLCSETIESYTQAMRDTAKRVGLSCDFDNEYLTDAPDYRAVTQSIFVDLFKRGDIVEDLRPNIYDPVEGTSIA 230
Cdd:pfam00133 95 YGREEFREKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIYRGKKLVNWSPALNTALS 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 231 EAEVQRITRETLLCDVRWTTEDGEDV--EISTTRPEMICACGVVVVHPD------------------------------- 277
Cdd:pfam00133 175 NLEVEYKDVKGPSIHVAFPLADDEGAslVIWTTTPWTLPGNTAVAVNPEfdyvitgegyilaeallkslykkgtdkkile 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 278 DQRYSHLVGKRVQLPMpvADREpsVEIITHPSVKMDFGSGVLMVCSFGDQNDVAVFRELGLKPFVAVDLDGRMTGISGPL 357
Cdd:pfam00133 255 DFRGKELEGKEAIHPF--VNRE--IPIITDDYVDMEFGTGAVHIAPAHGENDYEVGQRHNLEVINPVDDDGTFTEEAPDF 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 358 IGMSAENARAASIEILNESGRLTTTEKHMQEVPVSERGGNPVEIILLKEWYVRQTHILERLSELSDQSSFIPERNRQFLH 437
Cdd:pfam00133 331 QGVYRFDARKKIVELLTEKGLLLKIEPFTHSYPFCWRSGTPIIPRATPQWFVRMDELADQALEAVEKVQFVPKSGEKRYF 410
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 438 DWMDGISiDWPISRRRWYHTEVPIWYSEDGSRVVVPPHGAYVQPWRTKPPHGSEVLDRETREHLGsyqdlaDSLGDLVGE 517
Cdd:pfam00133 411 NWLANIQ-DWCISRQRWWGHPIPAWVSKDTEEVVCRGELFELVAGRFEEEGSIKWLHREAKDKLG------YGKGTLEQD 483
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 518 EKVFDTWMDSSNSNLYVSGY-ISDPELFRRAFPTSIRPQGKEIVRTWLYYTLLKSALLLDKPGFQNIWVDGLGMDPWGRK 596
Cdd:pfam00133 484 EDVLDTWFSSGSWPFSTLGWpFVNTEEFKKFFPADMLLEGSDQTRGWFYRMIMLSTALTGSVPFKNVLVHGLVRDEQGRK 563
|
570 580
....*....|....*....|
gi 663501384 597 MSKSLGNGIDADSVL-ECGA 615
Cdd:pfam00133 564 MSKSLGNVIDPLDVIdKYGA 583
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
83-658 |
4.15e-78 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 258.33 E-value: 4.15e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 83 EIFIIDTPPPYPSGTWHIGAVAQYSMIDVIARSQRLLGKEVRFPWGVDRNGINIEFTVERKHGRK---MRSYERGEFLDL 159
Cdd:cd00817 1 PVFVIDTPPPNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVVVEKKLGIEgktRHDLGREEFLEK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 160 CSETIESYTQAMRDTAKRVGLSCDFDNEYLTDAPDYRAVTQSIFVDLFKRGDIVEDLRPNIYDPVEGTSIAEAEVqritr 239
Cdd:cd00817 81 CWEWKEESGGKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIEV----- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 240 etllcdvrwttedgedveisttrpemicacgvvvvhpddqryshlvgkrvqlpmpvadrepsveiithpsvkmdfgsgvl 319
Cdd:cd00817 --------------------------------------------------------------------------------
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 320 mvcsfgdqndvavfrelglkpfvavdldgrmtgisgpligmsaenaraasieilnesgrltttekhmqevpvSERGGNPV 399
Cdd:cd00817 156 ------------------------------------------------------------------------CSRSGDVI 163
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 400 EIILLKEWYVRQTHILERLSELSDQSS--FIPERNRQFLHDWMDGISiDWPISRRRWYHTEVPIWYSEDGSRVVVPphga 477
Cdd:cd00817 164 EPLLKPQWFVKVKDLAKKALEAVKEGDikFVPERMEKRYENWLENIR-DWCISRQLWWGHRIPAWYCKDGGHWVVA---- 238
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 478 yvqpwRTKPphgsEVLDrETREHLGSYQDLADslgdLVGEEKVFDTWMDSSNSNLYVSGYISDPELFRRAFPTSIRPQGK 557
Cdd:cd00817 239 -----REED----EAID-KAAPEACVPCGGEE----LKQDEDVLDTWFSSSLWPFSTLGWPEETKDLKKFYPTSLLVTGH 304
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 558 EIVRTWLYYTLLKSALLLDKPGFQNIWVDGLGMDPWGRKMSKSLGNGIDADSVLecgaggrtgswrikgpdgkqiqlraN 637
Cdd:cd00817 305 DIIFFWVARMIMRGLKLTGKLPFKEVYLHGLVRDEDGRKMSKSLGNVIDPLDVI-------------------------D 359
|
570 580
....*....|....*....|.
gi 663501384 638 KIGSECFRLWKACDAQVGDDF 658
Cdd:cd00817 360 GYGADALRFTLASAATQGRDI 380
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
46-825 |
1.02e-76 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 267.36 E-value: 1.02e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 46 PKIPEKRWSidleKKIQESHYaetyskrysFDP-KSEREIFIIDTPPPYPSGTWHIGAVAQYSMIDVIARSQRLLGKEVR 124
Cdd:PRK05729 11 PKEVEAKWY----QKWEEKGY---------FKPdDNSKKPFSIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 125 fpW--GVDRNGINIEFTVERK---HGRKMRSYERGEFLDLCSETIESYTQAMRDTAKRVGLSCDFDNEYLT-DAPDYRAV 198
Cdd:PRK05729 78 --WlpGTDHAGIATQMVVERQlaaEGKSRHDLGREKFLEKVWEWKEESGGTITNQLRRLGASCDWSRERFTmDEGLSKAV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 199 TQsIFVDLFKRGDIVEDLRpnI--YDPVEGTSIAEAEVQRITRETLLCDVRWTTEDGED-VEISTTRPEMICACGVVVVH 275
Cdd:PRK05729 156 RE-VFVRLYEKGLIYRGKR--LvnWDPKLQTALSDLEVEYKEVKGKLWHIRYPLADGSDyLVVATTRPETMLGDTAVAVN 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 276 PDDQRYSHLVGKRVQLPmpVADREpsVEIITHPSVKMDFGSGVLMVCSFGDQNDVAVFRELGLkPFVAV-DLDGRMTGIS 354
Cdd:PRK05729 233 PEDERYKHLIGKTVILP--LVGRE--IPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNL-PMINImDEDGTINENP 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 355 GPLIGMSAENARAASIEILNESGRLTTTEKHMQEVPVSERGGNPVEIILLKEWYVRQTHILERLSEL--SDQSSFIPER- 431
Cdd:PRK05729 308 GEYQGLDRFEARKAIVADLEELGLLVKIEPHTHSVGHSDRSGVVIEPYLSDQWFVKMKPLAKPALEAveNGEIKFVPERw 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 432 NRQFLHdWMDGISiDWPISRRRWY-HtEVPIWYSEDGsRVVVPphgayvqpwRTKPPHGSEvldretrehlgsyqdlads 510
Cdd:PRK05729 388 EKTYFH-WMENIQ-DWCISRQLWWgH-RIPAWYDEDG-EVYVG---------REEPEAREK------------------- 435
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 511 lGDLVGEEKVFDTWMdSSN----SNLyvsGYISDPELFRRAFPTSIRPQGKEIVRTW--------LYYTllksalllDKP 578
Cdd:PRK05729 436 -ALLTQDEDVLDTWF-SSAlwpfSTL---GWPEKTEDLKRFYPTSVLVTGFDIIFFWvarmimmgLHFT--------GQV 502
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 579 GFQNIWVDGLGMDPWGRKMSKSLGNGID---------ADSvlecgaggrtgswrikgpdgkqiqLRankigsecFRLwkA 649
Cdd:PRK05729 503 PFKDVYIHGLVRDEQGRKMSKSKGNVIDpldlidkygADA------------------------LR--------FTL--A 548
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 650 CDAQVGDDFHINPEEIE-SKYFGvlTKLFNVARFA---SQFDVPGDLDDsPSGLPPEDLWILSEFGAVMEQVEGAwmdID 725
Cdd:PRK05729 549 ALASPGRDIRFDEERVEgYRNFA--NKLWNASRFVlmnLEGADVGELPD-PEELSLADRWILSRLNRTVAEVTEA---LD 622
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 726 IY---TAAQSLKGFGTGVFPSHWLEMSKSRLYDGDDSAT-WTLHRVVRDLLSTMSPICPFFCHYLSTTLYGSSAVD---V 798
Cdd:PRK05729 623 KYrfdEAARALYEFIWNEFCDWYLELAKPVLQEAAKRATrATLAYVLEQILRLLHPFMPFITEELWQKLAPLGIEEsimL 702
|
810 820
....*....|....*....|....*..
gi 663501384 799 RSFPRLPELMAPEDATYMRSLTPIISE 825
Cdd:PRK05729 703 APWPEADEAIDEAAEAEFEWLKELITA 729
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
56-781 |
8.04e-76 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 264.99 E-value: 8.04e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 56 DLEKK-----IQESHYAETYSKRYsF--DPKSEREIFIIDTPPPYPSGTWHIGAVAQYSMIDVIARSQRLLGKEVRfpW- 127
Cdd:COG0525 2 ELPKTydpkeVEAKWYQYWEENGY-FkaDPDSDKEPFTIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTL--Wq 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 128 -GVDRNGINIEFTVERK---HGRKMRSYERGEFLDLCSETIESYTQAMRDTAKRVGLSCDFDNEYLT-DAPDYRAVTQsI 202
Cdd:COG0525 79 pGTDHAGIATQAVVERQlaeEGKSRHDLGREKFLERVWEWKEESGGTITNQLRRLGASCDWSRERFTmDEGLSKAVRE-V 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 203 FVDLFKRGDIVEDLRpnI--YDPVEGTSIAEAEVQRITRETLLCDVRWTTEDGED-VEISTTRPEMICACGVVVVHPDDQ 279
Cdd:COG0525 158 FVRLYEKGLIYRGKR--LvnWDPKLKTALSDLEVEHEEVKGHLWHIRYPLADGSGyIVVATTRPETMLGDTAVAVHPEDE 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 280 RYSHLVGKRVQLPmpVADREpsVEIITHPSVKMDFGSGVLMVCSFGDQNDvavFrELGLK---PFVAV-DLDGRMTGISG 355
Cdd:COG0525 236 RYKHLIGKTVILP--LVGRE--IPIIADEYVDPEFGTGAVKITPAHDPND---F-EVGKRhnlPMINIlDEDGTINENAG 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 356 PLIGMSAENARAASIEILNESGRLTTTEKHMQEVPVSERGGNPVEIILLKEWYVRqthiLERLSE------LSDQSSFIP 429
Cdd:COG0525 308 KYRGLDRFEARKAIVADLEELGLLVKVEPHKHSVGHSDRSGTVIEPYLSDQWFVK----MKPLAKpaieavEDGEIKFVP 383
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 430 ER-NRQFLHdWMDGISiDWPISRRRWY-HtEVPIWYSEDGSRVVVpphgayvqpwRTKPphgsevldrETREHLGSyqdl 507
Cdd:COG0525 384 ERwEKTYFH-WMENIR-DWCISRQLWWgH-RIPAWYCPDGEVYVA----------RTEP---------EACAKAGS---- 437
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 508 adslGDLVGEEKVFDTWMdSSN----SNLyvsGYISDPELFRRAFPTSIRPQGKEIVRTW--------LYYTllksalll 575
Cdd:COG0525 438 ----VNLTQDEDVLDTWF-SSAlwpfSTL---GWPEKTEDLKYFYPTSVLVTGFDIIFFWvarmimmgLHFT-------- 501
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 576 DKPGFQNIWVDGLGMDPWGRKMSKSLGNGIDA-DSVLECGAggrtgswrikgpDGkqiqLRankigsecFRLwkACDAQV 654
Cdd:COG0525 502 GEVPFKDVYIHGLVRDEQGRKMSKSKGNVIDPlDLIDKYGA------------DA----LR--------FTL--AALASP 555
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 655 GDDFHINPEEIE-SKYFGvlTKLFNVARFASQF--DVPGDLDDSPSGLPPEDLWILSEFGAVMEQVEGAwmdIDIY---T 728
Cdd:COG0525 556 GRDIKFDEERVEgYRNFA--NKLWNASRFVLMNleGFDPGLDPDPEELSLADRWILSRLNKTIAEVTEA---LEKYrfdE 630
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|....*..
gi 663501384 729 AAQSLKGFGTGVFPSHWLEMSKSRLYDGDDSAT----WTLHRVVRDLLSTMSPICPF 781
Cdd:COG0525 631 AAQALYDFVWNEFCDWYLELAKPRLYGGDEAAKretrATLVYVLEQILRLLHPFMPF 687
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
63-802 |
3.18e-63 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 230.66 E-value: 3.18e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 63 ESHYAETYSKRYSFDPKSE------REIFIIDTPPPYPSGTWHIGAVAQYSMIDVIARSQRLLGKEVRFPWGVDRNGINI 136
Cdd:PTZ00419 34 ESGWYEWWEKSGFFKPAEDakslnsGKKFVIVLPPPNVTGYLHIGHALTGAIQDSLIRYHRMKGDETLWVPGTDHAGIAT 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 137 EFTVER---KHGRKMR-SYERGEFLDLCSETIESYTQAMRDTAKRVGLSCDFDNEYLT-DAPDYRAVTQSiFVDLFKRGD 211
Cdd:PTZ00419 114 QVVVEKklmKEENKTRhDLGREEFLKKVWEWKDKHGNNICNQLRRLGSSLDWSREVFTmDEQRSKAVKEA-FVRLYEDGL 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 212 IVEDLRPNIYDPVEGTSIAEAEVQ--RITRETLL--------CDVRWTT------EDGEDVEI--STTRPEMICACGVVV 273
Cdd:PTZ00419 193 IYRDTRLVNWCCYLKTAISDIEVEfeEIEKPTKItipgydkkVEVGVLWhfayplEDSGQEEIvvATTRIETMLGDVAVA 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 274 VHPDDQRYSHLVGKRVQLPMpVADREpsVEIITHPS-VKMDFGSGVLMVCSFGDQNDVAVFRELGLKPFVAVDLDGRMTG 352
Cdd:PTZ00419 273 VHPKDERYKKLHGKELIHPF-IPDRK--IPIIADDElVDMEFGTGAVKITPAHDPNDYEIAKRHNLPFINIFTLDGKINE 349
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 353 ISGPLIGMSAENARAASIEILNESGRLTTTEKHMQEVPVSERGGNPVEIILLKEWYVRQTHILERLSELSDQSSF--IPE 430
Cdd:PTZ00419 350 NGGEFAGMHRFDCRRKIEEELKEMGLLRDKVPNPMRLPRCSRSGDIVEPMLIPQWYVNCKDMAKRAVEAVRNGELkiIPS 429
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 431 RNRQFLHDWMDGISiDWPISRRRWYHTEVPIWysedgsRVV---VPPHGAYVQPWrtkpphgseVLDR---ETREHLGS- 503
Cdd:PTZ00419 430 SHENVWYHWLENIQ-DWCISRQLWWGHRIPAY------RVIskgPETDPSDEEPW---------VVARseeEALEKAKKk 493
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 504 YQDLADSLgDLVGEEKVFDTWMDSSNSNLYVSGYISDPELFRRAFPTSIRPQGKEIVRTWLYYTLLKSALLLDKPGFQNI 583
Cdd:PTZ00419 494 FGLSEEDF-ELEQDEDVLDTWFSSGLFPFSTLGWPDQTDDLQRFFPTSLLETGSDILFFWVARMVMMSLHLTDKLPFKTV 572
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 584 WVDGLGMDPWGRKMSKSLGNGIDADSVL--------------------------------------ECGAGG-RTG--SW 622
Cdd:PTZ00419 573 FLHAMVRDSQGEKMSKSKGNVIDPLEVIegislqdlnqklyegnlpekeikraielqkkefpngipECGTDAlRFGllAY 652
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 623 RIKGPDgkqIQLRANKI-GSE--CFRLWKACdaqvgddfhinpeeiesKY-FGVLTKLFNVARfaSQFDVPGDLDDspsg 698
Cdd:PTZ00419 653 TQQGRN---INLDINRVvGYRhfCNKLWNAV-----------------KFaLMKLLKDFNLPN--STLFKPNNVES---- 706
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 699 LPPEDLWILSEFGAVMEQVEGAWMDIDIYTAAQSLKGFGTGVFPSHWLEMSKSRLYDGDDS-----ATWTLHRVVRDLLS 773
Cdd:PTZ00419 707 LPWEDKWILHRLNVAIKEVTEGFKEYDFSEATQATYNFWLYELCDVYLELIKPRLSKQSDGerkqhAQDVLHTVLDIGLR 786
|
810 820 830
....*....|....*....|....*....|...
gi 663501384 774 TMSPICPFFC----HYLSTTLYGSSAVDVRSFP 802
Cdd:PTZ00419 787 LLHPMMPFITeelyQRLPNYLRKSESISIAKYP 819
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
68-781 |
6.63e-63 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 230.26 E-value: 6.63e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 68 ETYSKRYSF----------DPKSEREIFIIDTPPPYPSGTWHIGAVAQYSMIDVIARSQRLLGKEVRFPWGVDRNGINIE 137
Cdd:PRK14900 23 EVEARWYPFwqergyfhgdEHDRTRPPFSIVLPPPNVTGSLHLGHALTATLQDVLIRWKRMSGFNTLWLPGTDHAGIATQ 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 138 FTVERK----HGRKMRSYERGEFLDLCSETIESYTQAMRDTAKRVGLSCDFDNEYLT-DAPDYRAVtQSIFVDLFKRGDI 212
Cdd:PRK14900 103 MIVEKElkktEKKSRHDLGREAFLERVWAWKEQYGSRIGEQHKALGASLDWQRERFTmDEGLSRAV-REVFVRLHEEGLI 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 213 VEDLRPNIYDPVEGTSIAEAEVQ-RITRETLLCDVRWTTEDGE-DVEISTTRPEMICACGVVVVHPDDQRYSHLVGKRVQ 290
Cdd:PRK14900 182 YREKKLINWCPDCRTALSDLEVEhEEAHQGELWSFAYPLADGSgEIVVATTRPETMLGDTAVAVHPLDPRYMALHGKKVR 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 291 LPmpVADRE-PSVE--IITHPSvkmdFGSGVLMVCSFGDQNDVAVFRELGLKPFVAVDLDGRMTGISGPLIGMSAENARA 367
Cdd:PRK14900 262 HP--ITGRTfPIVAdaILVDPK----FGTGAVKVTPAHDFNDFEVGKRHGLEMITVIGPDGRMTAEAGPLAGLDRFEARK 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 368 ASIEILNESGRLTTTEKHMQEVPVSERGGNPVEIILLKEWYVRQTHILERLSELSDQ--SSFIPERNRQFLHDWMDGISi 445
Cdd:PRK14900 336 EVKRLLAEQGLDRGAKPHVLPLGRCQRSATILEPLLSDQWYVRIEPLARPAIEAVEQgrTRFIPEQWTNTYMAWMRNIH- 414
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 446 DWPISRRRWYHTEVPIWYSEDGSRVVVpphgayvqpwRTKPPHGSEVLDRETREhlgsyqdladslgdlvgEEKVFDTWM 525
Cdd:PRK14900 415 DWCISRQLWWGHQIPAWYCPDGHVTVA----------RETPEACSTCGKAELRQ-----------------DEDVLDTWF 467
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 526 DSSNSNLYVSGYISDPELFRRAFPTSIRPQGKEIVRTWLYYTLLKSALLLDKPGFQNIWVDGLGMDPWGRKMSKSLGNGI 605
Cdd:PRK14900 468 SSGLWPFSTMGWPEQTDTLRTFYPTSVMETGHDIIFFWVARMMMMGLHFMGEVPFRTVYLHPMVRDEKGQKMSKTKGNVI 547
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 606 DADSVLEcgaggrtgswrikgpdgkqiqlranKIGSECFRLWKACDAQVGDDFHINPEEIESkYFGVLTKLFNVARFA-- 683
Cdd:PRK14900 548 DPLVITE-------------------------QYGADALRFTLAALTAQGRDIKLAKERIEG-YRAFANKLWNASRFAlm 601
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 684 --SQFDVPGDlDDSPSGLPPEDLWILSEFGAVMEQVEGAWMDIDIYTAAQSLKGFGTGVFPSHWLEMSKSRLYDGD---- 757
Cdd:PRK14900 602 nlSGYQERGE-DPARLARTPADRWILARLQRAVNETVEALEAFRFNDAANAVYAFVWHELCDWYIELAKEALASEDpear 680
|
730 740
....*....|....*....|....
gi 663501384 758 DSATWTLHRVVRDLLSTMSPICPF 781
Cdd:PRK14900 681 RSVQAVLVHCLQTSYRLLHPFMPF 704
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
76-837 |
1.65e-59 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 219.43 E-value: 1.65e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 76 FDPKSER--EIFIIDTPPPYPSGTWHIGAVAQYSMIDVIARSQRLLGKEVRFPWGVDRNGINIEFTVER---KHGRKMRS 150
Cdd:PLN02943 79 FKPNFDRggDPFVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGIATQLVVEKmlaSEGIKRTD 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 151 YERGEFLDLCSETIESYTQAMRDTAKRVGLSCDFDNEYLT-DAPDYRAVTQSiFVDLFKRGDIVEDLRPNIYDPVEGTSI 229
Cdd:PLN02943 159 LGRDEFTKRVWEWKEKYGGTITNQIKRLGASCDWSRERFTlDEQLSRAVVEA-FVRLHEKGLIYQGSYMVNWSPNLQTAV 237
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 230 AEAEVQRITRETLLCDVRWTTEDGED--VEISTTRPEMICACGVVVVHPDDQRYSHLVGKRVQLPMPVADREPsveIITH 307
Cdd:PLN02943 238 SDLEVEYSEEPGTLYYIKYRVAGGSEdfLTIATTRPETLFGDVAIAVNPEDDRYSKYIGKMAIVPMTYGRHVP---IIAD 314
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 308 PSVKMDFGSGVLMVCSFGDQNDVAVFRELGLkPFVAV-DLDGRMTGISGpligMSAENARAASIEILNESGRLTTTEKHM 386
Cdd:PLN02943 315 RYVDKDFGTGVLKISPGHDHNDYLLARKLGL-PILNVmNKDGTLNEVAG----LYWFEAREKLWSDLEETGLAVKKEPHT 389
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 387 QEVPVSERGGNPVEIILLKEWYVRQTHILER-LSELSD-QSSFIPERNRQFLHDWMDGISiDWPISRRRWYHTEVPIWYS 464
Cdd:PLN02943 390 LRVPRSQRGGEVIEPLVSKQWFVTMEPLAEKaLKAVENgELTIIPERFEKIYNHWLSNIK-DWCISRQLWWGHRIPVWYI 468
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 465 EDgsrvvvpphgayvqpwrtKPPHGSEVLDRETREHLGSYQDLADSLGDLVGEEKVFDTWMDSSnsnLYVSGYISDPEL- 543
Cdd:PLN02943 469 VG------------------KDCEEDYIVARSAEEALEKAREKYGKDVEIYQDPDVLDTWFSSA---LWPFSTLGWPDVs 527
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 544 ---FRRAFPTSIRPQGKEIVRTWLYYTLLKSALLLDKPGFQNIWVDGLGMDPWGRKMSKSLGNGIDA-DSVLEcgaggrt 619
Cdd:PLN02943 528 aedFKKFYPTTVLETGHDILFFWVARMVMMGIEFTGTVPFSYVYLHGLIRDSQGRKMSKTLGNVIDPlDTIKE------- 600
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 620 gswrikgpdgkqiqlrankIGSECFRLWKACdAQVGDDFHINPEEIES-KYFgvLTKLFNVARFA-----SQFDVPG--- 690
Cdd:PLN02943 601 -------------------FGTDALRFTLAL-GTAGQDLNLSTERLTSnKAF--TNKLWNAGKFVlqnlpSQSDTSAweh 658
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 691 ------DLDDSPSGLPPEDLWILSEFGAVMEQVEGAWMDIDIYTAAQSLKGFGTGVFPSHWLEMSKSRLY-DGDDSATWT 763
Cdd:PLN02943 659 ilackfDKEESLLSLPLPECWVVSKLHELIDSVTTSYDKYFFGDVGREIYDFFWSDFADWYIEASKTRLYhSGDNSALSR 738
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 764 ----LHRVVRDLLSTMSPICPFFCHYLSTTL-YGSSAVDVRSFPR--LP-ELMAPEDATYMRSLTPIISEFNSE--VWKA 833
Cdd:PLN02943 739 aqavLLYVFENILKLLHPFMPFVTEELWQALpYRKEALIVSPWPQtsLPkDLKSIKRFENLQSLTRAIRNARAEysVEPA 818
|
....
gi 663501384 834 KKDS 837
Cdd:PLN02943 819 KRIS 822
|
|
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
46-841 |
1.36e-55 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 207.63 E-value: 1.36e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 46 PKI-PE--KRW-SIDLEKKIQESHyaetyskrysfdpkSEREIFI-IDTPPpYPSGTWHIG-AVAQYsmI-DVIARSQRL 118
Cdd:COG0060 19 PKRePEilKFWeENDIYEKSREAR--------------AGRPKFVlHDGPP-YANGDIHIGhALNKI--LkDIIVRYKTM 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 119 LGKEVRFPWGVDRNGINIEFTVERKHGRK---MRSYERGEFLDLCSETIESYTQAMRDTAKRVGLSCDFDNEYLTDAPDY 195
Cdd:COG0060 82 RGFDVPYVPGWDCHGLPIELKVEKELGIKkkdIEKVGIAEFREKCREYALKYVDEQREDFKRLGVWGDWDNPYLTMDPEY 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 196 RAVTQSIFVDLFKRGDIVEDLRPNIYDPVEGTSIAEAEVQRITRETLLCDVRWTTEDGEDVEIS--------TTRP---- 263
Cdd:COG0060 162 EESIWWALKKLYEKGLLYKGLKPVPWCPRCGTALAEAEVEYKDVTSPSIYVKFPVKDEKALLLLedaylviwTTTPwtlp 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 264 --EMICacgvvvVHPD----------DQRY---------------------------SHLVGKRVQLPMP-VADREPSVE 303
Cdd:COG0060 242 anLAVA------VHPDidyvlvevtgGERLilaealveavlkelgiedyevlatfkgAELEGLRYEHPFYyVVGYDRAHP 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 304 IITHPSVKMDFGSG-VLMVCSFGdQNDVAVFRELGLKPFVAVDLDGRMTGISGPLIGMSAENARAASIEILNESGRLTTT 382
Cdd:COG0060 316 VILGDYVTTEDGTGiVHTAPGHG-EDDFEVGKKYGLPVLNPVDDDGRFTEEAPLFAGLFVKDANPAIIEDLKERGALLAR 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 383 EKHMQEVPVSERGGNPveIIL--LKEWYVRQTHILERLSELSDQSSFIPE--RNRqfLHDWMDGiSIDWPISRRRWYHTE 458
Cdd:COG0060 395 EKITHSYPHCWRCKTP--LIYraTPQWFISMDKLRDRALEAIEKVNWIPEwgEGR--FGNMLEN-RPDWCISRQRYWGVP 469
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 459 VPIWYSEDGSRVVVPP------------HGAyvQPWRTKPPHgsevldretREHLGSYQDLADSLGDLVGEEKVFDTWMD 526
Cdd:COG0060 470 IPIWVCEDCGELHRTEevigsvaelleeEGA--DAWFELDLH---------RPFLDETLKCPKCGGTMRRVPDVLDVWFD 538
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 527 SSNS---------------NLYVSGyiSDpelfrrafptsirpQgkeiVRTWLYYTLLKSALLLDKPGFQNIWVDGLGMD 591
Cdd:COG0060 539 SGSMhfavlenreelhfpaDFYLEG--SD--------------Q----TRGWFYSSLLTSTALFGRAPYKNVLTHGFVLD 598
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 592 PWGRKMSKSLGNGIDADSVLecgaggrtgswrikgpdgkqiqlraNKIGSECFRLWKACDAQvGDDFHINPEEIESKYfG 671
Cdd:COG0060 599 EDGRKMSKSLGNVVDPQEVI-------------------------DKYGADILRLWVASSDY-WGDLRFSDEILKEVR-D 651
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 672 VLTKLFNVARF----ASQFDvPGDLDDSPSGLPPEDLWILSEFGAVMEQVEGAWMDIDIYTAAQSLKGFGTGVFpSHW-L 746
Cdd:COG0060 652 VYRRLRNTYRFllanLDDFD-PAEDAVPYEDLPELDRWILSRLNELIKEVTEAYDNYDFHRAYRALHNFCVEDL-SNWyL 729
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 747 EMSKSRLYDGDD------SATWTLHRVVRDLLSTMSPICPFFCHYLSTTLYGSSAVDV--RSFPRLPE-LMAPEDATYMR 817
Cdd:COG0060 730 DISKDRLYTEAAdsldrrAAQTTLYEVLETLVRLLAPILPFTAEEIWQNLPGEAEESVhlADWPEVDEeLIDEELEAKWD 809
|
890 900
....*....|....*....|....*.
gi 663501384 818 SLTPIISEFNSEVWKAKKDS--GLSL 841
Cdd:COG0060 810 LVREVRSAVLKALEAARKEKliRQPL 835
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
45-611 |
1.06e-47 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 184.33 E-value: 1.06e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 45 TPKIPEKRWSIDLEKK-----IQESHYAETYSKRY-SFDPKSEREIFIIDTPPPYPSGTWHIGAVAQYSMIDVIARSQRL 118
Cdd:PLN02381 84 TPFGQKKRLSSQMAKQyspsaVEKSWYAWWEKSGYfGADAKSSKPPFVIVLPPPNVTGALHIGHALTAAIEDTIIRWKRM 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 119 LGKEVRFPWGVDRNGINIEFTVERK--HGRKMRSYE--RGEFLDLCSETIESYTQAMRDTAKRVGLSCDFDNEYLT-DAP 193
Cdd:PLN02381 164 SGYNALWVPGVDHAGIATQVVVEKKlmRERHLTRHDigREEFVSEVWKWKDEYGGTILNQLRRLGASLDWSRECFTmDEQ 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 194 DYRAVTQSiFVDLFKRGDIVEDLRPNIYDPVEGTSIAEAEVQR--ITRETL--------------LCDVRWTTEDG-EDV 256
Cdd:PLN02381 244 RSKAVTEA-FVRLYKEGLIYRDIRLVNWDCTLRTAISDVEVDYidIKERTLlkvpgydkpvefgvLTSFAYPLEGGlGEI 322
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 257 EISTTRPEMICACGVVVVHPDDQRYSHLVGKRVQLPMPvADREPSV--EIITHPSvkmdFGSGVLMVCSFGDQNDVAVFR 334
Cdd:PLN02381 323 VVATTRIETMLGDTAIAIHPDDERYKHLHGKFAVHPFN-GRKLPIIcdAILVDPN----FGTGAVKITPAHDPNDFEVGK 397
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 335 ELGLKPFVAVDLDGRMTGISGP-LIGMSAENARAASIEILNESGRLTTTEKHMQEVPVSERGGNPVEIILLKEWYVR-QT 412
Cdd:PLN02381 398 RHNLEFINIFTDDGKINSNGGSeFAGMPRFAAREAVIEALQKKGLYRGAKNNEMRLGLCSRTNDVVEPMIKPQWFVNcSS 477
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 413 HILERLSELSDQSS----FIPERNRQFLHDWMDGISiDWPISRRRWYHTEVPIWY---SEDGSRVVvpphGAYVQPWrtk 485
Cdd:PLN02381 478 MAKQALDAAIDGENkkleFIPKQYLAEWKRWLENIR-DWCISRQLWWGHRIPAWYvtlEDDQLKEL----GSYNDHW--- 549
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 486 pphgseVLDR-ETREHLGSYQDLADSLGDLVGEEKVFDTWMDSSNSNLYVSGYISDPELFRRAFPTSIRPQGKEIVRTWL 564
Cdd:PLN02381 550 ------VVARnESDALLEASQKFPGKKFELSQDPDVLDTWFSSGLFPLSVLGWPDDTDDLKAFYPTSVLETGHDILFFWV 623
|
570 580 590 600
....*....|....*....|....*....|....*....|....*..
gi 663501384 565 YYTLLKSALLLDKPGFQNIWVDGLGMDPWGRKMSKSLGNGIDADSVL 611
Cdd:PLN02381 624 ARMVMMGMQLGGDVPFRKVYLHPMIRDAHGRKMSKSLGNVIDPLEVI 670
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
83-780 |
4.16e-37 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 150.69 E-value: 4.16e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 83 EIFIIDTPPPYPSGTWHIGAVAQYSMIDVIARSQRLLGKEVRFPWGVDRNGINIEFTV-------ERKH--GRKMRSYER 153
Cdd:PLN02843 32 ESFTLHDGPPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCHGLPIELKVlqsldqeARKEltPIKLRAKAA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 154 gEFldlCSETIEsytqAMRDTAKRVGLSCDFDNEYLTDAPDYRAVTQSIFVDLFKRGDIVEDLRPNIYDPVEGTSIAEAE 233
Cdd:PLN02843 112 -KF---AKKTVD----TQRESFKRYGVWGDWENPYLTLDPEYEAAQIEVFGQMFLNGYIYRGRKPVHWSPSSRTALAEAE 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 234 VQ--------------RIT----------RETL--LCDVRWTT-------------------------EDGEDVEISTTR 262
Cdd:PLN02843 184 LEypeghvsksiyvafPVVspsetspeelEEFLpgLSLAIWTTtpwtmpanaavavndklqysvvevqSFSEDESTSGGN 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 263 PEMICACGV-------VVVHPD-----------------DQRYSHLVGKRVQLPMpvADREPSVEI----ITHPSvkmdf 314
Cdd:PLN02843 264 KKKRPGNVLkeqqklfLIVATDlvpaleakwgvklvvlkTFPGSDLEGCRYIHPL--YNRESPVVIggdyITTES----- 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 315 GSGVLMVCSFGDQNDVAVFRELGLKPFVAVDLDGRMTGISGPLIGMSAENA-RAASIEILNESGRLTTTEKHMQEVPVSE 393
Cdd:PLN02843 337 GTGLVHTAPGHGQEDYITGLKYGLPLLSPVDDAGKFTEEAGQFSGLSVLGEgNAAVVEALDEAGSLLMEEAYGHKYPYDW 416
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 394 RGGNPVEIILLKEWYV-----RQthilERLSELsDQSSFIPERNRQFLHDWMDGISiDWPISRRRWYHTEVPIWYSEDgs 468
Cdd:PLN02843 417 RTKKPTIFRATEQWFAsvegfRQ----AALDAI-DKVKWIPAQGENRIRAMVSGRS-DWCISRQRTWGVPIPVFYHVE-- 488
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 469 rvvvpphgayvqpwrTKPPhgseVLDRETREHL-------GS---------------YQDLADslgDLVGEEKVFDTWMD 526
Cdd:PLN02843 489 ---------------TKEP----LMNEETIAHVksivaqkGSdawwymdvedllpekYRDKAS---DYEKGTDTMDVWFD 546
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 527 SSNSNLYVSGyiSDPELfrrAFPTSIRPQGKEIVRTWLYYTLLKSALLLDKPGFQNIWVDGLGMDPWGRKMSKSLGNGID 606
Cdd:PLN02843 547 SGSSWAGVLG--SREGL---SYPADLYLEGSDQHRGWFQSSLLTSVATKGKAPYKSVLTHGFVLDEKGFKMSKSLGNVVD 621
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 607 ADSVLEcgaGGRtgswrikgpDGKQiqlrANKIGSECFRLWKACDAQVGdDFHINPeEIESKYFGVLTKLFNVARFasqf 686
Cdd:PLN02843 622 PRLVIE---GGK---------NQKQ----EPAYGADVLRLWVASVDYTG-DVLIGP-QILKQMSDIYRKLRGTLRY---- 679
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 687 dVPGDLDD-------SPSGLPPEDLWILSEFGAVMEQVEGAWMDIDIYTAAQSLKGFGTGVFPSHWLEMSKSRLY-DGDD 758
Cdd:PLN02843 680 -LLGNLHDwkpdnavPYEDLPSIDKYALFQLENVVNEIEESYDNYQFFKIFQILQRFTIVDLSNFYLDVAKDRLYvGGTT 758
|
810 820
....*....|....*....|....*..
gi 663501384 759 SAT-----WTLHRVVRDLLSTMSPICP 780
Cdd:PLN02843 759 SFTrrscqTVLAAHLLSLLRAIAPILP 785
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
85-612 |
2.46e-35 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 136.78 E-value: 2.46e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 85 FIIDTPPPYPSGTWHIGAVAQYSMIDVIARSQRLLGKEVRFPWGVDRNGINIEFTVERKHGRKMRSYERGEFLDLCSETI 164
Cdd:cd00668 2 FYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAERKGGRKKKTIWIEEFREDPKEFV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 165 ESYTQAMRDTAKRVGLSCDFDNEYLTDAPDYRAVTQSIFVDLFKRGDIVEDLRPniydpvegtsiaeaevqritretllc 244
Cdd:cd00668 82 EEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIYRGTHP-------------------------- 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 245 dvrwttedgedveisttrpemicacgvvvVHPDDQryshlvgkrvqlpmpvadrepsveiithpsvkmdfgsgvlmvcsf 324
Cdd:cd00668 136 -----------------------------VRITEQ--------------------------------------------- 141
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 325 gdqndvavfrelglkpfvavdldgrmtgisgpligmsaenaraasieilnesgrltttekhmqevpvserggnpveiill 404
Cdd:cd00668 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 405 keWYVRQTHILERLSELSDQSSFIPERNRQFLHDWMDGIsIDWPISRRRWYHTEVPiwysedgsrvvvpphgayvqpwrt 484
Cdd:cd00668 142 --WFFDMPKFKEKLLKALRRGKIVPEHVKNRMEAWLESL-LDWAISRQRYWGTPLP------------------------ 194
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 485 kpphgsevldretrehlgsyqdladslgdlvgeEKVFDTWMDSSNSNLYVSGYISDPELFRRAFPTSIRPQGKEIVRTWL 564
Cdd:cd00668 195 ---------------------------------EDVFDVWFDSGIGPLGSLGYPEEKEWFKDSYPADWHLIGKDILRGWA 241
|
490 500 510 520
....*....|....*....|....*....|....*....|....*...
gi 663501384 565 YYTLLKSALLLDKPGFQNIWVDGLGMDPWGRKMSKSLGNGIDADSVLE 612
Cdd:cd00668 242 NFWITMLVALFGEIPPKNLLVHGFVLDEGGQKMSKSKGNVIDPSDVVE 289
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
72-806 |
4.38e-34 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 141.40 E-value: 4.38e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 72 KRYSFdPKSEREI----------------------FIIDTPPPYPSGTWHIGAVAQYSMIDVIARSQRLLGKEV--RFPW 127
Cdd:PLN02882 6 KDFSF-PKQEEKIlslwseidafktqlkrteglpeYIFYDGPPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVtrRFGW 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 128 gvDRNGINIEFTVERKHGRKmrsyERGEFLDL--------CSETIESYTQAMRDTAKRVGLSCDFDNEYLTDAPDYRAVT 199
Cdd:PLN02882 85 --DCHGLPVEYEIDKKLGIK----RRDDVLKMgidkyneeCRSIVTRYSKEWEKTVTRTGRWIDFENDYKTMDPKFMESV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 200 QSIFVDLFKRGDIVEDLRPNIYDPVEGTSIAEAEVQRITRET----------LLCD------VRWTTedgedveISTTRP 263
Cdd:PLN02882 159 WWVFKQLFEKGLVYKGFKVMPYSTACKTPLSNFEAGLNYKDVsdpavmvsfpIVGDpdnasfVAWTT-------TPWTLP 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 264 EMICACgvvvVHPD-----------DQRY--------------------------------------SHLVGKRVQ--LP 292
Cdd:PLN02882 232 SNLALC----VNPNftyvkvrnkytGKVYivaesrlsalptakpkskkgskpenaaegyevlakvpgSSLVGKKYEplFD 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 293 MPVADREPSVEIITHPSVKMDFGSGVLMVC-SFGdQNDVAVFRELGL-----KPFVAVDLDGRMTGISGPLIGMSAENAR 366
Cdd:PLN02882 308 YFSEFSDTAFRVVADDYVTDDSGTGVVHCApAFG-EDDYRVCLANGIiekggNLPVPVDDDGCFTEKVTDFSGRYVKDAD 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 367 AASIEILNESGRLTTTEKHMQEVPVSERGGNPVEIILLKEWYVRQTHILERLSELSDQSSFIPE--RNRQFlHDWMDGiS 444
Cdd:PLN02882 387 KDIIAAIKAKGRLVKSGSITHSYPFCWRSDTPLIYRAVPSWFVKVEEIKDRLLENNKQTYWVPDyvKEKRF-HNWLEN-A 464
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 445 IDWPISRRRWYHTEVPIWYSEDGSRVVVPPHGAYVQPWRtkpphGSEVLD--RETREHLGSYQDLADSLGDLVGEEKVFD 522
Cdd:PLN02882 465 RDWAVSRSRFWGTPLPIWISDDGEEVVVIGSIAELEKLS-----GVKVTDlhRHFIDHITIPSSRGPEFGVLRRVDDVFD 539
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 523 TWMDSSnSNLYvsGYISDP----ELFRRAFPTSIRPQGKEIVRTWLYYTLLKSALLLDKPGFQNIWVDGLGMDPWGRKMS 598
Cdd:PLN02882 540 CWFESG-SMPY--AYIHYPfenkELFEKNFPADFVAEGLDQTRGWFYTLMVLSTALFDKPAFKNLICNGLVLAEDGKKMS 616
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 599 KSLGNGIDADSVLecgaggrtgswrikgpdgkqiqlraNKIGSECFRLwkacdaqvgddFHINPEEI--------ESKYF 670
Cdd:PLN02882 617 KSLKNYPDPNEVI-------------------------DKYGADALRL-----------YLINSPVVraeplrfkEEGVF 660
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 671 GVLTKLF----NVARFASQ------------FdVPGDLDDSPSGLPPEDLWILSEFGAVMEQVEGAWMDIDIYTAAQSLK 734
Cdd:PLN02882 661 GVVKDVFlpwyNAYRFLVQnakrleveggapF-VPLDLAKLQNSANVLDRWINSATQSLVKFVREEMGAYRLYTVVPYLV 739
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 735 GFGTGVfPSHWLEMSKSRL--YDGDD---SATWTLHRVVRDLLSTMSPICPFFCHY----LSTTLYGSS-AVDVRSFPRL 804
Cdd:PLN02882 740 KFIDNL-TNIYVRFNRKRLkgRTGEEdcrTALSTLYNVLLTSCKVMAPFTPFFTEVlyqnLRKVLPGSEeSIHYCSFPQV 818
|
..
gi 663501384 805 PE 806
Cdd:PLN02882 819 DE 820
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
398-657 |
8.30e-26 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 109.63 E-value: 8.30e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 398 PVEIILLKEWYVRQTHILERLSELSDQSSFIPERNRQFLHDWMDGiSIDWPISRRRWYHTEVPIWYSEDGSRVVVpphga 477
Cdd:cd00818 144 PLIYRATPQWFIRVTKIKDRLLEANDKVNWIPEWVKNRFGNWLEN-RRDWCISRQRYWGTPIPVWYCEDCGEVLV----- 217
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 478 yvqpwrtkpphgsevldreTREhlgsyqdladslgdlvgeEKVFDTWMDSSNSNLYVSGYISDPELFRRAFPTSIRPQGK 557
Cdd:cd00818 218 -------------------RRV------------------PDVLDVWFDSGSMPYAQLHYPFENEDFEELFPADFILEGS 260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 558 EIVRTWLYYTLLKSALLLDKPGFQNIWVDGLGMDPWGRKMSKSLGNGIDADSVLecgaggrtgswrikgpdgkqiqlraN 637
Cdd:cd00818 261 DQTRGWFYSLLLLSTALFGKAPYKNVIVHGFVLDEDGRKMSKSLGNYVDPQEVV-------------------------D 315
|
250 260
....*....|....*....|
gi 663501384 638 KIGSECFRLWKACDAQVGDD 657
Cdd:cd00818 316 KYGADALRLWVASSDVYAED 335
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
673-786 |
6.25e-20 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 86.46 E-value: 6.25e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 673 LTKLFNVARFASQFDVPGDLDDSPSG-LPPEDLWILSEFGAVMEQVEGAWMDIDIYTAAQSLKGFGTGVFPSHWLEMSKS 751
Cdd:cd07962 13 CNKLWNAARFVLMNLEDDDEPEEDPEsLSLADRWILSRLNKTVEEVTEALENYRFSEAATALYEFFWNDFCDWYLELVKP 92
|
90 100 110
....*....|....*....|....*....|....*....
gi 663501384 752 RLYDGDD----SATWTLHRVVRDLLSTMSPICPFFCHYL 786
Cdd:cd07962 93 RLYGEDEeekkAARATLYYVLETILRLLHPFMPFITEEL 131
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
82-612 |
1.64e-17 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 87.71 E-value: 1.64e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 82 REIFIIDTPPPYPSGTWHIGAVAQYSMIDVIARSQRLLGKEVRFPWGVDRNGINIEFTVERKHGRKMRSYERGEFLDL-- 159
Cdd:PTZ00427 101 KKAYIFYDGPPFATGLPHYGHLLAGIIKDCVTRYFYQCGFSVERKFGWDCHGLPIEYEIEKENNINKKEDILKMGIDVyn 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 160 --CSETIESYTQAMRDTAKRVGLSCDFDNEYLTDAPDYRAVTQSIFVDLFKRGDIVEDLRPNIYDPVEGTSIAEAEVQRI 237
Cdd:PTZ00427 181 ekCRGIVLKYSNEWVKTVERIGRWIDFKNDYKTMDKTFMESVWWVFSELYKNNYVYKSFKVMPYSCKCNTPISNFELNLN 260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 238 TRET----------LLCDVRWTTED--GEDV------------------------------------EIST------TRP 263
Cdd:PTZ00427 261 YKDTpdpsiiisfvLCSDFPKVEEEcnIEEDkqllgekysvlynnkrensnngnnnstnnvcyaqhsEILAwtttpwTLP 340
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 264 EMICACgvVVVHPDDQRYSHLVGKRV-------------QLPMPVAD------------------------------REP 300
Cdd:PTZ00427 341 SNLALC--VNEHFTYLRIHHVKSNRVvivgecrlewimkELKWNVEDlkivnrfkgkelkglrykplftnfyekynfKER 418
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 301 SVEIITHPSVKMDFGSGVLMVCSFGDQNDVAVFRELG-LKP----FV-AVDLDGRMTGISGPLIGMSAENARAASIEILN 374
Cdd:PTZ00427 419 AYKILADDFVTDDAGTGIVHCAPTYGEDDFRVCKKNGvIDPekniFIdPLDANGYFTNEVEEVQNLYIKEADNVIKKKLK 498
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 375 ESGRLTTTEKHMQEVPVSERGGNPVEIILLKEWYVRQTHILERLSELSDQSSFIPE--RNRQFlHDWMDGISiDWPISRR 452
Cdd:PTZ00427 499 NENRLLSNNTIVHSYPFCWRSDTPLIYRAIPAWFIRVSNSTNELVKNNETTYWIPAhiKEKKF-HNWIKDAK-DWCISRN 576
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 453 RWYHTEVPIWYSEDGSRVVVPPHGAYVQpwRTKPPHGSEVLDRETREHLGSYQDLADSLGDLVGEEKVFDTWMDSSnSNL 532
Cdd:PTZ00427 577 RYWGTPIPIWADEKMETVICVESIKHLE--ELSGVKNINDLHRHFIDHIEIKNPKGKTYPKLKRIPEVFDCWFESG-SMP 653
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 533 YVS---GYISDPELFRRAFPTSIRPQGKEIVRTWLYYTLLKSALLLDKPGFQNIWVDGLGMDPWGRKMSKSLGNGIDADS 609
Cdd:PTZ00427 654 YAKvhyPFSTEKEDFHKIFPADFIAEGLDQTRGWFYTLLVISTLLFDKAPFKNLICNGLVLASDGKKMSKRLKNYPDPLY 733
|
...
gi 663501384 610 VLE 612
Cdd:PTZ00427 734 ILD 736
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
85-215 |
2.62e-16 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 80.75 E-value: 2.62e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 85 FIIDTPPPYPSGTWHIGAVAQYSMIDVIARSQRLLGKEVRFPWGVDRNGINIE-FTVERKHGRKmrsyergefldlcsET 163
Cdd:cd00812 2 FYILVMFPYPSGALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPAEnAAIKIGRDPE--------------DW 67
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 663501384 164 IESYTQAMRDTAKRVGLSCDFDNEYLTDAPDYRAVTQSIFVDLFKRGDIVED 215
Cdd:cd00812 68 TEYNIKKMKEQLKRMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKK 119
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
703-846 |
3.96e-15 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 73.21 E-value: 3.96e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 703 DLWILSEFGAVMEQVEGAWMDIDIYTAAQSLKGFGTGVFPSHWLEMSKSRLY--DGDDSATWTLHRVVRDLLSTMSPICP 780
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFWNDLSDWYLELIKDRLYgeEPDSRAQTTLYEVLETLLRLLAPFMP 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 663501384 781 FFCHYlsttLYGSSAVDVRSFPRLPELMAPEDATYMRSLTPIIsefnSEVWKAKKDSGLSLKSPIS 846
Cdd:pfam08264 81 FITEE----LWQKESIHLAPWPEDAELEEAELEEAFELRQEIV----QAIRKLRSELKIKKSLPLE 138
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
85-227 |
6.95e-14 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 75.15 E-value: 6.95e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 85 FIIDTPPPYPSGTWHIGAVAQYSMIDVIARSQRLLGKEVRFPWGVDRNGINIEFTVErKHGRKMRSYergefldlcsetI 164
Cdd:COG0143 3 FLVTTAIPYANGPPHIGHLYTYIPADILARYQRLRGHDVLFVTGTDEHGTKIELAAE-KEGITPQEL------------V 69
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 663501384 165 ESYTQAMRDTAKRVGLScdFDNEYLTDAPDYRAVTQSIFVDLFKRGDIVEDLRPNIYDPVEGT 227
Cdd:COG0143 70 DRIHAEFKELFEKLGIS--FDNFIRTTSPEHKELVQEIFQRLYDNGDIYKGEYEGWYCPECER 130
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
92-612 |
9.12e-13 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 72.39 E-value: 9.12e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 92 PYPSGTWHIGAVAQYSMIDVIARSQRLLGKEVRFPWGVD-----------RNGI--------NIEftverkhgrkmrsye 152
Cdd:COG0495 42 PYPSGRLHMGHVRNYTIGDVVARYKRMQGYNVLHPMGWDafglpaenaaiKNGVhpaewtyeNIA--------------- 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 153 rgefldlcsetiesytqAMRDTAKRVGLSCDFDNEYLTDAPDYRAVTQSIFVDLFKRGDIVEDLRP-NiYDPVEGTSIAE 231
Cdd:COG0495 107 -----------------NMRRQLKRLGLSYDWSREIATCDPEYYKWTQWIFLQLYEKGLAYRKEAPvN-WCPVDQTVLAN 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 232 AEV------------------Q---RITR--ETLL--------------------------CDVRWTTED-GEDVEISTT 261
Cdd:COG0495 169 EQVidgrcwrcgapvekkelpQwflKITDyaDELLddldkldgwpekvktmqrnwigrsegAEVDFPVEGsDEKITVFTT 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 262 RPEMIcaCGV--VVVHPDdqrysH-LVGKRVQlpmpvADREPSVE-----------------------IIT-----HPS- 309
Cdd:COG0495 249 RPDTL--FGAtfMVLAPE-----HpLVKELAT-----PEQNAAVAafieeakkkseiertsetkektgVFTglyaiNPLt 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 310 -----------VKMDFGSGVLMVCSFGDQNDVAVFRELGLkPFVAV------DLDGRMT------GI---SGPLIGMSAE 363
Cdd:COG0495 317 gekipiwiadyVLMDYGTGAVMAVPAHDQRDFEFAKKYGL-PIKQViapedgDDPDILEeaytgdGVlinSGEFDGLDSE 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 364 NARAASIEILNES--GRLTTTekhmqevpvserggnpveiillkewYvrqthileRLselsdqssfipeRnrqflhdwmd 441
Cdd:COG0495 396 EAKEAIIEWLEEKglGKRKVN-------------------------Y--------RL------------R---------- 420
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 442 gisiDWPISRRRWYHTEVPIWYSEDGSRVVVP---------------PHG----AYVQPWR--TKPPHGSEVLdRETreh 500
Cdd:COG0495 421 ----DWLISRQRYWGEPIPIIHCEDCGVVPVPedqlpvelpedvdfdPTGgsplARAPEWVnvTCPKCGGPAR-RET--- 492
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 501 lgsyqDladslgdlvgeekVFDTWMDSSnsnLYVSGYIsDPELFRRAFptsirpqGKEIVRTW----------------- 563
Cdd:COG0495 493 -----D-------------TMDTFVDSS---WYYLRYT-DPHNDEAPF-------DPEAANYWlpvdqyiggiehailhl 543
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 663501384 564 LY---YT-------LLKSalllDKPgFQN---------IWVDGLGMDPWGrKMSKSLGNGIDADSVLE 612
Cdd:COG0495 544 LYarfFTkvlrdlgLVSF----DEP-FKRlltqgmvleVGKDGVVIGGIE-KMSKSKGNVVDPDEIIE 605
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
85-235 |
9.45e-13 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 70.78 E-value: 9.45e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 85 FIIDTPPPYPSGTWHIGAVAQYSMIDVIARSQRLLGKEVRFPWGVDRNGINIEFTVErKHGRkmrsyergEFLDLCseti 164
Cdd:pfam09334 1 ILVTTALPYANGPPHLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGTPIELKAE-KEGI--------TPEELV---- 67
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 663501384 165 ESYTQAMRDTAKRVGLScdFDNEYLTDAPDYRAVTQSIFVDLFKRGDIVEDLRPNIYDPVEGTSIAEAEVQ 235
Cdd:pfam09334 68 DRYHEIHREDFKKFNIS--FDDYGRTTSERHHELVQEFFLKLYENGYIYEKEIEQFYCPSDERFLPDRYVE 136
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
672-800 |
2.20e-12 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 66.42 E-value: 2.20e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 672 VLTKLFNVARFASQ------FDvPGDLDDSPSGLPPEDLWILSEFGAVMEQVEGAWMDIDIYTAAQSLKGFGTGVfpSHW 745
Cdd:cd07961 13 VLLPLWNAYRFFVTyanldgFD-PGKDDDAVASLNVLDRWILSRLNSLIKEVTEEMEAYDLYTAVRALLEFIDEL--TNW 89
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 663501384 746 -LEMSKSRLYDGDDS-----ATWTLHRVVRDLLSTMSPICPFFCHYLSTTLYGSSAVDVRS 800
Cdd:cd07961 90 yIRRNRKRFWGEEGDddklaAYATLYEVLLTLSRLMAPFTPFITEEIYQNLRRELGDAPES 150
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
85-231 |
1.82e-11 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 66.40 E-value: 1.82e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 85 FIIDTPPPYPSGTWHIGAVAQYSMIDVIARSQRLLGKEVRFPWGVDRNGINIEFTVErKHGRkmrsyergEFLDLCSEti 164
Cdd:cd00814 2 VLITTALPYVNGVPHLGHLYGTVLADVFARYQRLRGYDVLFVTGTDEHGTKIEQKAE-EEGV--------TPQELCDK-- 70
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 663501384 165 esYTQAMRDTAKRVGLScdFDNEYLTDAPDYRAVTQSIFVDLFKRGDIVEDLRPNIYDPVEGTSIAE 231
Cdd:cd00814 71 --YHEIFKDLFKWLNIS--FDYFIRTTSPRHKEIVQEFFKKLYENGYIYEGEYEGLYCVSCERFLPE 133
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
85-212 |
1.55e-09 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 61.44 E-value: 1.55e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 85 FIIDTPPPYPSGTWHIGAVaqYSMI--DVIARSQRLLGKEVRFPWGVDrnginieftverKHGRKM--RSYERG----EF 156
Cdd:PRK11893 3 FYITTPIYYPNGKPHIGHA--YTTLaaDVLARFKRLRGYDVFFLTGTD------------EHGQKIqrKAEEAGispqEL 68
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 663501384 157 LDLCSETIESYTQAMrdtakrvglSCDFDNEYLTDAPDYRAVTQSIFVDLFKRGDI 212
Cdd:PRK11893 69 ADRNSAAFKRLWEAL---------NISYDDFIRTTDPRHKEAVQEIFQRLLANGDI 115
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
92-234 |
3.69e-09 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 60.61 E-value: 3.69e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 92 PYPSGT-WHIGAVAQYSMIDVIARSQRLLGKEVRFPWGVDRNGINIE-FTVERkhGRKMRSyergefldlcseTIESYTQ 169
Cdd:PLN02563 119 PYPSGAgLHVGHPEGYTATDILARYKRMQGYNVLHPMGWDAFGLPAEqYAIET--GTHPKI------------TTLKNIA 184
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 663501384 170 AMRDTAKRVGLSCDFDNEYLTDAPDYRAVTQSIFVDLFKRGDIVEDLRPNIYDPVEGTSIAEAEV 234
Cdd:PLN02563 185 RFRSQLKSLGFSYDWDREISTTEPEYYKWTQWIFLQLLKRGLAYQAEVPVNWCPALGTVLANEEV 249
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
98-460 |
4.55e-08 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 57.19 E-value: 4.55e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 98 WHIGAVAQYSMIDVIARSQRLLGKEVRFPWGVDRNG---INIEFTVERKHGRKMRSYErgEFLDLCSETIESYT------ 168
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLFPMAFHVTGtpiLGIAERIARGDPETIELYK--SLYGIPEEELEKFKdpeyiv 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 169 ----QAMRDTAKRVGLSCDFDNEYLTDAPDYRAVTQSIFVDLFKRGDIVEDLRPNIYDPVEGT-----SIAEAEVQRITR 239
Cdd:PRK12300 79 eyfsEEAKEDMKRIGYSIDWRREFTTTDPEYSKFIEWQFRKLKEKGLIVKGSHPVRYCPNDNNpvgdhDLLDGEEPEIVE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 240 ETLlcdVRWTTEDGEDVEISTTRPEMICacGV-----------VVVHPDDQRY-------------------------SH 283
Cdd:PRK12300 159 YTL---IKFEESEDLILPAATLRPETIF--GVtnlwvnpdatyVKAEVDGEKWivskeaaeklsfqdrdveiieeikgSE 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 284 LVGKRVQlpMPVADREpsveIITHPS--VKMDFGSGVLM---------------------------------VCSFGDQN 328
Cdd:PRK12300 234 LIGKKVK--NPVTGKE----VPILPAdfVDPDNGTGVVMsvpahapydyvalrdlkknkelldviepiplieVEGYGEFP 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 329 DVAVFRELGLKPFVAVDLD-------------GRMTGISGPLIGMSAENARAASIEILNESGRLTTtekhMQEV---PVS 392
Cdd:PRK12300 308 AKEVVEKLGIKSQEDPELEeatkevyraefhkGVLKENTGEYAGKPVREAREKITKDLIEKGIADI----MYEFsnrPVY 383
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 393 ERGGNPVEIILLK---------EWYVRQTHilerlsELSDQSSFIPERNRQFLH---DWMDgisiDWPISRRRWYHTEVP 460
Cdd:PRK12300 384 CRCGTECVVKVVKdqwfidysdPEWKELAH------KALDNMEIIPEEYRKEFEntiDWLK----DRACARRRGLGTRLP 453
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
92-227 |
1.32e-07 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 55.54 E-value: 1.32e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 92 PYPSGTWHIGAVAQYSMIDVIARSQRLLGKEVRFPWGVDRNGINIEFTVErKHGRKMRsyergefldlcsETIESYTQAM 171
Cdd:PRK00133 11 PYANGPIHLGHLVEYIQADIWVRYQRMRGHEVLFVCADDAHGTPIMLKAE-KEGITPE------------ELIARYHAEH 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 663501384 172 RDTAKRVGLScdFDNEYLTDAPDYRAVTQSIFVDLFKRGDIVEDLRPNIYDP----------VEGT 227
Cdd:PRK00133 78 KRDFAGFGIS--FDNYGSTHSEENRELAQEIYLKLKENGYIYEKTIEQLYDPekgmflpdrfVKGT 141
|
|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
66-212 |
2.23e-07 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 54.72 E-value: 2.23e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 66 YAETYSKRYSFDpksEREIFIIDTPPPYPSGTWHIGAVAQYSMIDVIARSQRLLGKEVRFPWGVDRNGINIEfTVERKHG 145
Cdd:PLN02224 55 YCTSSSQESTVD---EADTFVLTTPLYYVNAPPHMGSAYTTIAADSIARFQRLLGKKVIFITGTDEHGEKIA-TSAAANG 130
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 663501384 146 RKmrsyeRGEFLDLCSetiESYTQAMRDtakrvgLSCDFDNEYLTDAPDYRAVTQSIFVDLFKRGDI 212
Cdd:PLN02224 131 RN-----PPEHCDIIS---QSYRTLWKD------LDIAYDKFIRTTDPKHEAIVKEFYARVFANGDI 183
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
85-212 |
1.40e-05 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 48.64 E-value: 1.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 85 FIIDTPPPYPSGTWHIGAVaqYSMI--DVIARSQRLLGKEVRFPWGVDRNGINIEFTVErkhgrkmrsyERG----EFLD 158
Cdd:PRK12267 6 FYITTPIYYPNGKPHIGHA--YTTIaaDALARYKRLQGYDVFFLTGTDEHGQKIQQAAE----------KAGktpqEYVD 73
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 663501384 159 LCSETIesytqamRDTAKRVGLSCDfdnEYL--TDaPDYRAVTQSIFVDLFKRGDI 212
Cdd:PRK12267 74 EISAGF-------KELWKKLDISYD---KFIrtTD-ERHKKVVQKIFEKLYEQGDI 118
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
524-606 |
1.71e-05 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 48.64 E-value: 1.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 524 WMDS-SNsnlYVS--GYIS-DPELFRRAFPTSIRPQGKEIVR----TWLyyTLLKSallLDKPGFQNIWVDG-LGMDpwG 594
Cdd:PRK12267 228 WIDAlLN---YITalGYGSdDDELFKKFWPADVHLVGKDILRfhaiYWP--IMLMA---LGLPLPKKVFAHGwWLMK--D 297
|
90
....*....|..
gi 663501384 595 RKMSKSLGNGID 606
Cdd:PRK12267 298 GKMSKSKGNVVD 309
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
520-613 |
9.04e-03 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 39.48 E-value: 9.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 520 VFDTWMDssnsnlYVSGYIS----------DPELFRRAFPTSIRPQGKEIVRTWLYY--TLLKSALLldkPGFQNIWVDG 587
Cdd:PRK11893 221 VIYVWFD------ALTNYLTalgypddeelLAELFNKYWPADVHLIGKDILRFHAVYwpAFLMAAGL---PLPKRVFAHG 291
|
90 100 110
....*....|....*....|....*....|
gi 663501384 588 lgmdpW----GRKMSKSLGNGIDADSVLEC 613
Cdd:PRK11893 292 -----FltldGEKMSKSLGNVIDPFDLVDE 316
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
517-612 |
9.27e-03 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 39.05 E-value: 9.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663501384 517 EEKVFDTWMDSsnsnlyVSGYIS----------DPELFRRAFPTSIRPQGKEIVRtwlYYTLLKSALLL--DKPGFQNIW 584
Cdd:cd00814 199 PGKVIYVWFDA------LIGYISatgyyneewgNSWWWKDGWPELVHFIGKDIIR---FHAIYWPAMLLgaGLPLPTRIV 269
|
90 100
....*....|....*....|....*....
gi 663501384 585 VDG-LGMDpwGRKMSKSLGNGIDADSVLE 612
Cdd:cd00814 270 AHGyLTVE--GKKMSKSRGNVVDPDDLLE 296
|
|
| |
