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Conserved domains on  [gi|663515100|gb|AIF05590|]
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ribose-phosphate pyrophosphokinase subfamily (PRPS, prsA) [uncultured marine group II/III euryarchaeote KM3_185_F04]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK00934 super family cl46892
ribose-phosphate pyrophosphokinase; Provisional
 3-304 4.58e-97

ribose-phosphate pyrophosphokinase; Provisional


The actual alignment was detected with superfamily member PRK00934:

Pssm-ID: 481232 [Multi-domain]  Cd Length: 285  Bit Score: 287.58  E-value: 4.58e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100   3 VVSGSSGRGVASSLAPLMGMQYIELESRRFPDGEGYVRVPTEaidaVRSEPVVLVSNTYPDS-GIVSTLLLLEAiadvrr 81
Cdd:PRK00934   2 IIGGSASQLLASEVARLLNTELALVETKRFPDGELYVRILGE----IDGEDVVIISTTYPQDeNLVELLLLIDA------ 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100  82 gdlsnLKGEEPQSMDdvgggvfLAIPYYGYSRQDKRFSKGEAVSARVIAEILARGCDGIAILDLHEPAVLEGMDVPIEFV 161
Cdd:PRK00934  72 -----LRDEGAKSIT-------LVIPYLGYARQDKRFKPGEPISARAIAKIISAYYDRIITINIHEPSILEFFPIPFINL 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100 162 SSMPEIAELLQSEVSPDFVLSPDKGAISRATEVAGLIGCDFSYLEKTRIDAHTIEHTPKDLDVGGKVVAIVDDMISTGGT 241
Cdd:PRK00934 140 DAAPLIAEYIGDKLDDPLVLAPDKGALELAKEAAEILGCEYDYLEKTRISPTEVEIAPKNLDVKGKDVLIVDDIISTGGT 219

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 663515100 242 ICRASDALRRQGATEVHAACTHGLFTGGAILRL-ANHVDGVHSTDSLPNPRAVVSAAPALARGL 304
Cdd:PRK00934 220 MATAIKILKEQGAKKVYVACVHPVLVGDAILKLyNAGVDEIIVTDTLESEVSKISVAPLIADLL 283
 
Name Accession Description Interval E-value
PRK00934 PRK00934
ribose-phosphate pyrophosphokinase; Provisional
 3-304 4.58e-97

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 234868 [Multi-domain]  Cd Length: 285  Bit Score: 287.58  E-value: 4.58e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100   3 VVSGSSGRGVASSLAPLMGMQYIELESRRFPDGEGYVRVPTEaidaVRSEPVVLVSNTYPDS-GIVSTLLLLEAiadvrr 81
Cdd:PRK00934   2 IIGGSASQLLASEVARLLNTELALVETKRFPDGELYVRILGE----IDGEDVVIISTTYPQDeNLVELLLLIDA------ 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100  82 gdlsnLKGEEPQSMDdvgggvfLAIPYYGYSRQDKRFSKGEAVSARVIAEILARGCDGIAILDLHEPAVLEGMDVPIEFV 161
Cdd:PRK00934  72 -----LRDEGAKSIT-------LVIPYLGYARQDKRFKPGEPISARAIAKIISAYYDRIITINIHEPSILEFFPIPFINL 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100 162 SSMPEIAELLQSEVSPDFVLSPDKGAISRATEVAGLIGCDFSYLEKTRIDAHTIEHTPKDLDVGGKVVAIVDDMISTGGT 241
Cdd:PRK00934 140 DAAPLIAEYIGDKLDDPLVLAPDKGALELAKEAAEILGCEYDYLEKTRISPTEVEIAPKNLDVKGKDVLIVDDIISTGGT 219

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 663515100 242 ICRASDALRRQGATEVHAACTHGLFTGGAILRL-ANHVDGVHSTDSLPNPRAVVSAAPALARGL 304
Cdd:PRK00934 220 MATAIKILKEQGAKKVYVACVHPVLVGDAILKLyNAGVDEIIVTDTLESEVSKISVAPLIADLL 283
ribP_PPkin TIGR01251
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In ...
 1-306 6.52e-82

ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In some systems, close homologs lacking enzymatic activity exist and perform regulatory functions. The model is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 273523 [Multi-domain]  Cd Length: 308  Bit Score: 249.89  E-value: 6.52e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100    1 MPVVSGSSGRGVASSLAPLMGMQYIELESRRFPDGEGYVRVPtEAIDAvrSEPVVLVSNTYP--DSGIVSTLLLLEAiad 78
Cdd:TIGR01251   1 MKIFSGSSNQELAQKVAKNLGLPLGDVEVKRFPDGELYVRIN-ESVRG--KDVFIIQQSTSApvNDNLMELLIMIDA--- 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100   79 VRRGDLSNLKgeepqsmddvgggvfLAIPYYGYSRQDKRFSKGEAVSARVIAEIL-ARGCDGIAILDLHEPAVLEGMDVP 157
Cdd:TIGR01251  75 LKRASAKSIT---------------AVIPYYGYARQDKKFKSREPISAKLVANLLeTAGADRVLTVDLHSPQIQGFFDVP 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100  158 IEFVSSMPEIAE-LLQSEVSPDFVLSPDKGAISRATEVAGLIGCDFSYLEKTRIDAH-TIEHTPKDLDVGGKVVAIVDDM 235
Cdd:TIGR01251 140 VDNLYASPVLAEyLKKKILDNPVVVSPDAGGVERAKKVADALGCPLAIIDKRRISATnEVEVMNLVGDVEGKDVVIVDDI 219

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 663515100  236 ISTGGTICRASDALRRQGATEVHAACTHGLFTGGAILRLAN-HVDGVHSTDSLPNPRA-----VVSAAPALARGLQR 306
Cdd:TIGR01251 220 IDTGGTIAKAAEILKSAGAKRVIAAATHGVFSGPAIERIANaGVEEVIVTNTIPHEKHkpkvsVISVAPLIAEAIRR 296
PrsA COG0462
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ...
 3-309 8.32e-81

Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis


Pssm-ID: 440230 [Multi-domain]  Cd Length: 311  Bit Score: 247.28  E-value: 8.32e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100   3 VVSGSSGRGVASSLAPLMGMQYIELESRRFPDGEGYVRVPteaiDAVRSEPVVLVSNTYP--DSGIVSTLLLLEAI--AD 78
Cdd:COG0462    6 IFSGNANPELAEEIAEYLGVPLGKAEVRRFSDGEIYVRIE----ESVRGRDVFVIQSTSPpvNDNLMELLIMIDALkrAS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100  79 VRRgdlsnlkgeepqsmddvgggVFLAIPYYGYSRQDKRFSKGEAVSARVIAEIL-ARGCDGIAILDLHEPAVLEGMDVP 157
Cdd:COG0462   82 ARR--------------------ITAVIPYYGYARQDRKFRPREPITAKLVADLLeAAGADRVLTVDLHAPQIQGFFDIP 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100 158 IEFVSSMPEIAELLQSEVSPDFVL-SPDKGAISRATEVAGLIGCDFSYLEKTRIDAHTIEHTPKDLDVGGKVVAIVDDMI 236
Cdd:COG0462  142 VDHLYAAPLLADYIKSKDLEDLVVvSPDVGGVKRARAFAKRLGAPLAIIDKRRPGANEVEVMNIIGDVEGKTCIIVDDMI 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100 237 STGGTICRASDALRRQGATEVHAACTHGLFTGGAILRLANH-VDGVHSTDSLPNPRA-------VVSAAPALARGLQRLM 308
Cdd:COG0462  222 DTGGTLVEAAEALKEAGAKSVYAAATHGVLSGPAVERLENSpIDELVVTDTIPLPEEkrcdkikVLSVAPLLAEAIRRIH 301


                 .
gi 663515100 309 E 309
Cdd:COG0462  302 E 302
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 167-286 3.71e-21

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 87.07  E-value: 3.71e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100 167 IAELLQSEVSPDFVLSPDKGAISRATEVAGLIGCDFSYLEKTRIDA------HTIEHTPKDLDVGGKVVAIVDDMISTGG 240
Cdd:cd06223    6 AEEIREDLLEPDVVVGILRGGLPLAAALARALGLPLAFIRKERKGPgrtpsePYGLELPLGGDVKGKRVLLVDDVIATGG 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 663515100 241 TICRASDALRRQGATEVHAACTHGLFTGGAILrLANHVDGVHSTDS 286
Cdd:cd06223   86 TLLAAIELLKEAGAKVVGVAVLLDKPEGGARE-LASPGDPVYSLFT 130
Pribosyltran_N pfam13793
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ...
 1-133 8.41e-14

N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.


Pssm-ID: 433483 [Multi-domain]  Cd Length: 117  Bit Score: 66.67  E-value: 8.41e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100    1 MPVVSGSSGRGVASSLAPLMGMQYIELESRRFPDGEGYVRVPteaiDAVRSEPVVLVSNTYPD--SGIVSTLLLLEAI-- 76
Cdd:pfam13793   1 LKIFSGNSNPELAEKIAKRLGIPLGKATVSRFSDGEIYVRIE----ESVRGKDVFIIQSTCPPvnDNLMELLIMIDALkr 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 663515100   77 ADVRRgdlsnlkgeepqsmddvgggVFLAIPYYGYSRQDKRFSKGEAVSARVIAEIL 133
Cdd:pfam13793  77 ASAKR--------------------ITAVIPYFGYARQDRKDKPREPITAKLVADLL 113
 
Name Accession Description Interval E-value
PRK00934 PRK00934
ribose-phosphate pyrophosphokinase; Provisional
 3-304 4.58e-97

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 234868 [Multi-domain]  Cd Length: 285  Bit Score: 287.58  E-value: 4.58e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100   3 VVSGSSGRGVASSLAPLMGMQYIELESRRFPDGEGYVRVPTEaidaVRSEPVVLVSNTYPDS-GIVSTLLLLEAiadvrr 81
Cdd:PRK00934   2 IIGGSASQLLASEVARLLNTELALVETKRFPDGELYVRILGE----IDGEDVVIISTTYPQDeNLVELLLLIDA------ 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100  82 gdlsnLKGEEPQSMDdvgggvfLAIPYYGYSRQDKRFSKGEAVSARVIAEILARGCDGIAILDLHEPAVLEGMDVPIEFV 161
Cdd:PRK00934  72 -----LRDEGAKSIT-------LVIPYLGYARQDKRFKPGEPISARAIAKIISAYYDRIITINIHEPSILEFFPIPFINL 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100 162 SSMPEIAELLQSEVSPDFVLSPDKGAISRATEVAGLIGCDFSYLEKTRIDAHTIEHTPKDLDVGGKVVAIVDDMISTGGT 241
Cdd:PRK00934 140 DAAPLIAEYIGDKLDDPLVLAPDKGALELAKEAAEILGCEYDYLEKTRISPTEVEIAPKNLDVKGKDVLIVDDIISTGGT 219

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 663515100 242 ICRASDALRRQGATEVHAACTHGLFTGGAILRL-ANHVDGVHSTDSLPNPRAVVSAAPALARGL 304
Cdd:PRK00934 220 MATAIKILKEQGAKKVYVACVHPVLVGDAILKLyNAGVDEIIVTDTLESEVSKISVAPLIADLL 283
ribP_PPkin TIGR01251
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In ...
 1-306 6.52e-82

ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In some systems, close homologs lacking enzymatic activity exist and perform regulatory functions. The model is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 273523 [Multi-domain]  Cd Length: 308  Bit Score: 249.89  E-value: 6.52e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100    1 MPVVSGSSGRGVASSLAPLMGMQYIELESRRFPDGEGYVRVPtEAIDAvrSEPVVLVSNTYP--DSGIVSTLLLLEAiad 78
Cdd:TIGR01251   1 MKIFSGSSNQELAQKVAKNLGLPLGDVEVKRFPDGELYVRIN-ESVRG--KDVFIIQQSTSApvNDNLMELLIMIDA--- 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100   79 VRRGDLSNLKgeepqsmddvgggvfLAIPYYGYSRQDKRFSKGEAVSARVIAEIL-ARGCDGIAILDLHEPAVLEGMDVP 157
Cdd:TIGR01251  75 LKRASAKSIT---------------AVIPYYGYARQDKKFKSREPISAKLVANLLeTAGADRVLTVDLHSPQIQGFFDVP 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100  158 IEFVSSMPEIAE-LLQSEVSPDFVLSPDKGAISRATEVAGLIGCDFSYLEKTRIDAH-TIEHTPKDLDVGGKVVAIVDDM 235
Cdd:TIGR01251 140 VDNLYASPVLAEyLKKKILDNPVVVSPDAGGVERAKKVADALGCPLAIIDKRRISATnEVEVMNLVGDVEGKDVVIVDDI 219

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 663515100  236 ISTGGTICRASDALRRQGATEVHAACTHGLFTGGAILRLAN-HVDGVHSTDSLPNPRA-----VVSAAPALARGLQR 306
Cdd:TIGR01251 220 IDTGGTIAKAAEILKSAGAKRVIAAATHGVFSGPAIERIANaGVEEVIVTNTIPHEKHkpkvsVISVAPLIAEAIRR 296
PrsA COG0462
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ...
 3-309 8.32e-81

Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis


Pssm-ID: 440230 [Multi-domain]  Cd Length: 311  Bit Score: 247.28  E-value: 8.32e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100   3 VVSGSSGRGVASSLAPLMGMQYIELESRRFPDGEGYVRVPteaiDAVRSEPVVLVSNTYP--DSGIVSTLLLLEAI--AD 78
Cdd:COG0462    6 IFSGNANPELAEEIAEYLGVPLGKAEVRRFSDGEIYVRIE----ESVRGRDVFVIQSTSPpvNDNLMELLIMIDALkrAS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100  79 VRRgdlsnlkgeepqsmddvgggVFLAIPYYGYSRQDKRFSKGEAVSARVIAEIL-ARGCDGIAILDLHEPAVLEGMDVP 157
Cdd:COG0462   82 ARR--------------------ITAVIPYYGYARQDRKFRPREPITAKLVADLLeAAGADRVLTVDLHAPQIQGFFDIP 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100 158 IEFVSSMPEIAELLQSEVSPDFVL-SPDKGAISRATEVAGLIGCDFSYLEKTRIDAHTIEHTPKDLDVGGKVVAIVDDMI 236
Cdd:COG0462  142 VDHLYAAPLLADYIKSKDLEDLVVvSPDVGGVKRARAFAKRLGAPLAIIDKRRPGANEVEVMNIIGDVEGKTCIIVDDMI 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100 237 STGGTICRASDALRRQGATEVHAACTHGLFTGGAILRLANH-VDGVHSTDSLPNPRA-------VVSAAPALARGLQRLM 308
Cdd:COG0462  222 DTGGTLVEAAEALKEAGAKSVYAAATHGVLSGPAVERLENSpIDELVVTDTIPLPEEkrcdkikVLSVAPLLAEAIRRIH 301


                 .
gi 663515100 309 E 309
Cdd:COG0462  302 E 302
PRK07199 PRK07199
ribose-phosphate diphosphokinase;
8-309 7.02e-51

ribose-phosphate diphosphokinase;


Pssm-ID: 235960 [Multi-domain]  Cd Length: 301  Bit Score: 170.12  E-value: 7.02e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100   8 SGRGVASSLAPLMGMQYIELESRRFPDGEGYVRVPTEAIDAvrsEPVVLVSNTYPDSGIVStlLLLEAIAdVRRGDLSNl 87
Cdd:PRK07199  10 GNEAAAGRLAAALGVEVGRIELHRFPDGESYVRLDSPVAGR---TVVLVCSLDRPDEKLLP--LLFAAEA-ARELGARR- 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100  88 kgeepqsmddvgggVFLAIPYYGYSRQDKRFSKGEAVSARVIAEILARGCDGIAILD--LHEPAVL-EGMDVPIEFVSSM 164
Cdd:PRK07199  83 --------------VGLVAPYLAYMRQDIAFHPGEAISQRHFARLLSGSFDRLVTVDphLHRYPSLsEVYPIPAVVLSAA 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100 165 PEIAELLQSEVSPDFVLSPDKGAISRATEVAGLIGCDFSYLEKTRIDAHTIEHT-PKDLDVGGKVVAIVDDMISTGGTIC 243
Cdd:PRK07199 149 PAIAAWIRAHVPRPLLIGPDEESEQWVAAVAERAGAPHAVLRKTRHGDRDVEISlPDAAPWAGRTPVLVDDIVSTGRTLI 228

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 663515100 244 RASDALRRQGATEVHAACTHGLFTGGAILRLAN-HVDGVHSTDSLPNPRAVVSAAPALARGLQRLME 309
Cdd:PRK07199 229 EAARQLRAAGAASPDCVVVHALFAGDAYSALAAaGIARVVSTDTVPHPSNAISLAPLLAEALRREFD 295
PRK01259 PRK01259
ribose-phosphate diphosphokinase;
1-309 1.96e-41

ribose-phosphate diphosphokinase;


Pssm-ID: 234929 [Multi-domain]  Cd Length: 309  Bit Score: 145.65  E-value: 1.96e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100   1 MPVVSGSSGRGVASSLAPLMGMQYIELESRRFPDGEgyVRVPTEaiDAVRSEPVVLVSNT-YP--DSgIVSTLLLLEAIa 77
Cdd:PRK01259   1 MKLFAGNANPELAEKIAKYLGIPLGKASVGRFSDGE--ISVEIN--ENVRGKDVFIIQSTcAPtnDN-LMELLIMIDAL- 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100  78 dvRRGDlsnlkgeepqsmddvGGGVFLAIPYYGYSRQDKRFSKGEAVSARVIAEILAR-GCDGIAILDLHEPAVLEGMDV 156
Cdd:PRK01259  75 --KRAS---------------AGRITAVIPYFGYARQDRKARSRVPITAKLVANLLETaGADRVLTMDLHADQIQGFFDI 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100 157 PIEFVSSMPEIAELLQSEVSPDF-VLSPDKGAISRATEVAGLIGCDFSYLEKTRIDAHTIEHTPKDLDVGGKVVAIVDDM 235
Cdd:PRK01259 138 PVDNLYGSPILLEDIKQKNLENLvVVSPDVGGVVRARALAKRLDADLAIIDKRRPRANVSEVMNIIGDVEGRDCILVDDM 217

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100 236 ISTGGTICRASDALRRQGATEVHAACTHGLFTGGAILRLANHV-DGVHSTDSLPNPRA--------VVSAAPALARGLQR 306
Cdd:PRK01259 218 IDTAGTLCKAAEALKERGAKSVYAYATHPVLSGGAIERIENSViDELVVTDSIPLSEEakkcdkirVLSVAPLLAEAIRR 297


                 ...
gi 663515100 307 LME 309
Cdd:PRK01259 298 ISN 300
PLN02369 PLN02369
ribose-phosphate pyrophosphokinase
 10-306 6.52e-39

ribose-phosphate pyrophosphokinase


Pssm-ID: 215209 [Multi-domain]  Cd Length: 302  Bit Score: 139.06  E-value: 6.52e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100  10 RGVASSLAPLMGMQYIELESRRFPDGEGYVRVPteaiDAVRSEPVVLVSNTYPDS--GIVSTLLLLEAIadvRRGDLSNl 87
Cdd:PLN02369   1 PALSQEIACYLGLELGKITIKRFADGEIYVQLQ----ESVRGCDVFLVQPTCPPAneNLMELLIMIDAC---RRASAKR- 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100  88 kgeepqsmddvgggVFLAIPYYGYSRQDKRFSKGEAVSARVIAEILAR-GCDGIAILDLHEPAVLEGMDVPIEFVSSMPE 166
Cdd:PLN02369  73 --------------ITAVIPYFGYARADRKTQGRESIAAKLVANLITEaGADRVLACDLHSGQSMGYFDIPVDHVYGQPV 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100 167 IAELLQSEV--SPDF-VLSPDKGAISRATEVA-GLIGCDFSYLEKTRIDAHTIEhtPKDL--DVGGKVVAIVDDMISTGG 240
Cdd:PLN02369 139 ILDYLASKTisSPDLvVVSPDVGGVARARAFAkKLSDAPLAIVDKRRQGHNVAE--VMNLigDVKGKVAIMVDDMIDTAG 216

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 663515100 241 TICRASDALRRQGATEVHAACTHGLFTGGAILRLANHV-DGVHSTDSLP--NPRA-----VVSAAPALARGLQR 306
Cdd:PLN02369 217 TITKGAALLHQEGAREVYACATHAVFSPPAIERLSSGLfQEVIVTNTIPvsEKNYfpqltVLSVANLLGETIWR 290
PRK03092 PRK03092
ribose-phosphate diphosphokinase;
13-309 1.36e-37

ribose-phosphate diphosphokinase;


Pssm-ID: 179535 [Multi-domain]  Cd Length: 304  Bit Score: 135.46  E-value: 1.36e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100  13 ASSLAPLMGMQYIELESRRFPDGEGYVRVPteaiDAVR-SEPVVLVSNTYP-DSGIVSTLLLLEAI--ADVRRgdlsnlk 88
Cdd:PRK03092   2 AEEVAKELGVEVTPTTAYDFANGEIYVRFE----ESVRgCDAFVLQSHTAPiNKWLMEQLIMIDALkrASAKR------- 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100  89 geepqsmddvgggVFLAIPYYGYSRQDKRFSKGEAVSARVIAEIL-ARGCDGIAILDLHEPAVLEGMDVPIEFVSSMPEI 167
Cdd:PRK03092  71 -------------ITVVLPFYPYARQDKKHRGREPISARLVADLFkTAGADRIMTVDLHTAQIQGFFDGPVDHLFAMPLL 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100 168 AELLQSEVSPD--FVLSPDKGAISRATEVAG-LIGCDFSYLEKTR-------IDAHTIEHtpkdlDVGGKVVAIVDDMIS 237
Cdd:PRK03092 138 ADYVRDKYDLDnvTVVSPDAGRVRVAEQWADrLGGAPLAFIHKTRdptvpnqVVANRVVG-----DVEGRTCVLVDDMID 212

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100 238 TGGTICRASDALRRQGATEVHAACTHGLFTGGAILRLAN-HVDGVHSTDSLPNPR-------AVVSAAPALARGLQRLME 309
Cdd:PRK03092 213 TGGTIAGAVRALKEAGAKDVIIAATHGVLSGPAAERLKNcGAREVVVTDTLPIPEekrfdklTVLSIAPLLARAIREVFE 292
PRK02269 PRK02269
ribose-phosphate diphosphokinase;
7-309 5.68e-36

ribose-phosphate diphosphokinase;


Pssm-ID: 167353 [Multi-domain]  Cd Length: 320  Bit Score: 131.45  E-value: 5.68e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100   7 SSGRGVASSLAPLMGMQYIELESRRFPDGEGYVRVPteaiDAVRSEPV-VLVSNTYP-DSGIVSTLLLLEAIadvRRGDL 84
Cdd:PRK02269  12 SSNKELAEKVAQEIGIELGKSSVRQFSDGEIQVNIE----ESIRGHHVfILQSTSSPvNDNLMEILIMVDAL---KRASA 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100  85 SNlkgeepqsmddvgggVFLAIPYYGYSRQDKRFSKGEAVSARVIAEILAR-GCDGIAILDLHEPAVLEGMDVPIEFVSS 163
Cdd:PRK02269  85 ES---------------INVVMPYYGYARQDRKARSREPITSKLVANMLEVaGVDRLLTVDLHAAQIQGFFDIPVDHLMG 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100 164 MPEIAELL--QSEVSPDFVL-SPDKGAISRATEVAGLIGCDFSYLEKTR--IDAHTIEHTPKDLDVGGKVVAIVDDMIST 238
Cdd:PRK02269 150 APLIADYFdrRGLVGDDVVVvSPDHGGVTRARKLAQFLKTPIAIIDKRRsvDKMNTSEVMNIIGNVKGKKCILIDDMIDT 229

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 663515100 239 GGTICRASDALRRQGATEVHAACTHGLFTGGAILRLANH-VDGVHSTDS--LPNPRAV-----VSAAPALARGLQRLME 309
Cdd:PRK02269 230 AGTICHAADALAEAGATEVYASCTHPVLSGPALDNIQKSaIEKLVVLDTiyLPEERLIdkieqISIADLLGEAIIRIHE 308
PRK02812 PRK02812
ribose-phosphate pyrophosphokinase; Provisional
 3-309 3.59e-32

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 235072 [Multi-domain]  Cd Length: 330  Bit Score: 121.77  E-value: 3.59e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100   3 VVSGSSGRGVASSLAPLMGMQYIELESRRFPDGEGYVRVPteaiDAVRSEPVVLVSntyPDSGIVSTLL--LLEAIADVR 80
Cdd:PRK02812  24 LFSGSSNPALAQEVARYLGMDLGPMIRKRFADGELYVQIQ----ESIRGCDVYLIQ---PTCAPVNDHLmeLLIMVDACR 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100  81 RGDLSNLKGeepqsmddvgggvflAIPYYGYSRQDKRFSKGEAVSARVIAEILAR-GCDGIAILDLHEPAVLEGMDVPIE 159
Cdd:PRK02812  97 RASARQITA---------------VIPYYGYARADRKTAGRESITAKLVANLITKaGADRVLAMDLHSAQIQGYFDIPCD 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100 160 FVSSMPEIAELLQSEVSPDFVL-SPDKGAISRATEVAG-LIGCDFSYLEKTRiDAHTIEHTPKDL-DVGGKVVAIVDDMI 236
Cdd:PRK02812 162 HVYGSPVLLDYLASKNLEDIVVvSPDVGGVARARAFAKkLNDAPLAIIDKRR-QAHNVAEVLNVIgDVKGKTAILVDDMI 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100 237 STGGTICRASDALRRQGATEVHAACTHGLFTGGAILRLANHV-DGVHSTDSLPNPR-------AVVSAAPALARGLQRLM 308
Cdd:PRK02812 241 DTGGTICEGARLLRKEGAKQVYACATHAVFSPPAIERLSSGLfEEVIVTNTIPVPEerrfpqlKVLSVANMLGEAIWRIH 320


                 .
gi 663515100 309 E 309
Cdd:PRK02812 321 E 321
PTZ00145 PTZ00145
phosphoribosylpyrophosphate synthetase; Provisional
 3-287 1.17e-29

phosphoribosylpyrophosphate synthetase; Provisional


Pssm-ID: 240290 [Multi-domain]  Cd Length: 439  Bit Score: 116.90  E-value: 1.17e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100   3 VVSGSSGRGVASSLAPLMGMQYIELESRRFPDGEgyvrVPTEAIDAVRSEPVVLVSNTYP--DSGIVSTLLLleaIADVR 80
Cdd:PTZ00145 122 LFSGSSNPLLSKNIADHLGTILGRVHLKRFADGE----VSMQFLESIRGKDVYIIQPTCPpvNENLIELLLM---ISTCR 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100  81 RGDLSNLKGeepqsmddvgggvflAIPYYGYSRQDKRFSKGEAVSARVIAEIL-ARGCDGIAILDLHEPAV--LEGMDVP 157
Cdd:PTZ00145 195 RASAKKITA---------------VIPYYGYARQDRKLSSRVPISAADVARMIeAMGVDRVVAIDLHSGQIqgFFGPRVP 259

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100 158 IE-FVSSMPEIAELLQSEVSPDFVLSPDKGAISRATEVA-GLIG-----CDFSYLEKTRIDAHTIEHTPKDLDVGGKVVA 230
Cdd:PTZ00145 260 VDnLEAQLIGLDYFTKKDLYKPVIVSPDAGGVYRARKFQdGLNHrgisdCGIAMLIKQRTKPNEIEKMDLVGNVYDSDVI 339

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 663515100 231 IVDDMISTGGTICRASDALRRQGATEVHAACTHGLFTGGAILRLANH-VDGVHSTDSL 287
Cdd:PTZ00145 340 IVDDMIDTSGTLCEAAKQLKKHGARRVFAFATHGLFSGPAIERIEASpLEEVVVTDTV 397
PRK04923 PRK04923
ribose-phosphate diphosphokinase;
3-288 2.72e-29

ribose-phosphate diphosphokinase;


Pssm-ID: 179893 [Multi-domain]  Cd Length: 319  Bit Score: 113.87  E-value: 2.72e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100   3 VVSGSSGRGVASSLAPLMGMQYIELESRRFPDGEgyvrVPTEAIDAVRSEPVVLVSNTYPDSG--IVSTLLLLEAIadvR 80
Cdd:PRK04923   9 VFSGNANKPLAQSICKELGVRMGKALVTRFSDGE----VQVEIEESVRRQEVFVIQPTCAPSAenLMELLVLIDAL---K 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100  81 RGDLSNlkgeepqsmddvgggVFLAIPYYGYSRQDKRF-SKGEAVSARVIAE-ILARGCDGIAILDLHEPAVLEGMDVPI 158
Cdd:PRK04923  82 RASAAS---------------VTAVIPYFGYSRQDRRMrSSRVPITAKVAAKmISAMGADRVLTVDLHADQIQGFFDVPV 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100 159 EFVSSMP-EIAELLQSEVSPDF-VLSPDKGAISRATEVAGLIG-CDFSYLEKTRIDAHTIEHTPKDLDVGGKVVAIVDDM 235
Cdd:PRK04923 147 DNVYASPlLLADIWRAYGTDNLiVVSPDVGGVVRARAVAKRLDdADLAIIDKRRPRANVATVMNIIGDVQGKTCVLVDDL 226

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 663515100 236 ISTGGTICRASDALRRQGATEVHAACTHGLFTGGAILRLANHV-DGVHSTDSLP 288
Cdd:PRK04923 227 VDTAGTLCAAAAALKQRGALKVVAYITHPVLSGPAVDNINNSQlDELVVTDTIP 280
PRK00553 PRK00553
ribose-phosphate pyrophosphokinase; Provisional
 3-288 2.43e-28

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 179062 [Multi-domain]  Cd Length: 332  Bit Score: 111.55  E-value: 2.43e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100   3 VVSGSSGRGVASSLAPLMGMQYIELESRRFPDGEGYVRvPTEAidaVRSEPVVLVSNTYPDSGIvSTLLLLEAIADVRRG 82
Cdd:PRK00553  12 IFSLSKAKKLVDSICRKLSMKPGEIVIQKFADGETYIR-FDES---VRNKDVVIFQSTCSPVND-SLMELLIAIDALKRG 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100  83 DLSNLKGeepqsmddvgggvflAIPYYGYSRQDKRFSKGEAVSARVIAEILAR-GCDGIAILDLHEPAVLEGMDVPIEFV 161
Cdd:PRK00553  87 SAKSITA---------------ILPYYGYARQDRKTAGREPITSKLVADLLTKaGVTRVTLTDIHSDQTQGFFDIPVDIL 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100 162 SS----MPEIAELLQSEvspDFVL-SPDKGAISRATEVAGLIGCDFSYLEKTRiDAHTIEHTPKDL-DVGGKVVAIVDDM 235
Cdd:PRK00553 152 RTyhvfLSRVLELLGKK---DLVVvSPDYGGVKRARLIAESLELPLAIIDKRR-PKHNVAESINVLgEVKNKNCLIVDDM 227

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 663515100 236 ISTGGTICRASDALRRQGATEVHAACTHGLFTGGAILRL-----ANHVDGVHSTDSLP 288
Cdd:PRK00553 228 IDTGGTVIAAAKLLKKQKAKKVCVMATHGLFNKNAIQLFdeafkKKLIDKLFVSNSIP 285
PRK02458 PRK02458
ribose-phosphate pyrophosphokinase; Provisional
 1-309 1.81e-27

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 235039 [Multi-domain]  Cd Length: 323  Bit Score: 109.06  E-value: 1.81e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100   1 MPVVSGSSGRGVASSLAPLMGMQYIELESRRFPDGEGYVRVPteaiDAVRSEPVVLVSNT-YPDSGIVSTLLLLeaIADV 79
Cdd:PRK02458  10 IKLFSLNSNLEIAEKIAQAAGVPLGKLSSRQFSDGEIMINIE----ESVRGDDIYIIQSTsFPVNDHLWELLIM--IDAC 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100  80 RRGDLSNlkgeepqsmddvgggVFLAIPYYGYSRQDKRFSKGEAVSARVIAEILAR-GCDGIAILDLHEPAVLEGMDVPI 158
Cdd:PRK02458  84 KRASANT---------------VNVVLPYFGYARQDRIAKPREPITAKLVANMLVKaGVDRVLTLDLHAVQVQGFFDIPV 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100 159 EFVSSMPEIAE------LLQSEVspdFVLSPDKGAISRATEVAGLIGC-----DFSYLEKTRIDAHTIEhtpkdlDVGGK 227
Cdd:PRK02458 149 DNLFTVPLFAKhyckkgLSGSDV---VVVSPKNSGIKRARSLAEYLDApiaiiDYAQDDSEREEGYIIG------DVAGK 219

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100 228 VVAIVDDMISTGGTICRASDALRRQGATEVHAACTHGLFTGGAILRLANH-------VDGVHSTDSLPNPRAVVSAAPAL 300
Cdd:PRK02458 220 KAILIDDILNTGKTFAEAAKIVEREGATEIYAVASHGLFAGGAAEVLENApikeilvTDSVATKERVPKNVTYLSASELI 299


                 ....*....
gi 663515100 301 ARGLQRLME 309
Cdd:PRK02458 300 ADAIIRIHE 308
PRK06827 PRK06827
phosphoribosylpyrophosphate synthetase; Provisional
 106-269 1.39e-22

phosphoribosylpyrophosphate synthetase; Provisional


Pssm-ID: 180714 [Multi-domain]  Cd Length: 382  Bit Score: 96.56  E-value: 1.39e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100 106 IPYYGYSRQDKRFSKgEAVSARVIAEILAR-GCDGIAILDLHEPAV--------LEGMDVPIEFVSSMpeIAELLQSEVS 176
Cdd:PRK06827 129 MPFLYESRQHKRKGR-ESLDCALALQELEElGVDNIITFDAHDPRIenaiplmgFENLYPSYQIIKAL--LKNEKDLEID 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100 177 PD--FVLSPDKGAISRATEVAGLIGCDFSYLEKTRIDAHT-------IEHTPKDLDVGGKVVAIVDDMISTGGTICRASD 247
Cdd:PRK06827 206 KDhlMVISPDTGAMDRAKYYASVLGVDLGLFYKRRDYSRVvngrnpiVAHEFLGRDVEGKDVLIVDDMIASGGSMIDAAK 285

                        170       180
                 ....*....|....*....|..
gi 663515100 248 ALRRQGATEVHAACTHGLFTGG 269
Cdd:PRK06827 286 ELKSRGAKKIIVAATFGFFTNG 307
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 167-286 3.71e-21

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 87.07  E-value: 3.71e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100 167 IAELLQSEVSPDFVLSPDKGAISRATEVAGLIGCDFSYLEKTRIDA------HTIEHTPKDLDVGGKVVAIVDDMISTGG 240
Cdd:cd06223    6 AEEIREDLLEPDVVVGILRGGLPLAAALARALGLPLAFIRKERKGPgrtpsePYGLELPLGGDVKGKRVLLVDDVIATGG 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 663515100 241 TICRASDALRRQGATEVHAACTHGLFTGGAILrLANHVDGVHSTDS 286
Cdd:cd06223   86 TLLAAIELLKEAGAKVVGVAVLLDKPEGGARE-LASPGDPVYSLFT 130
Pribosyltran_N pfam13793
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ...
 1-133 8.41e-14

N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.


Pssm-ID: 433483 [Multi-domain]  Cd Length: 117  Bit Score: 66.67  E-value: 8.41e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100    1 MPVVSGSSGRGVASSLAPLMGMQYIELESRRFPDGEGYVRVPteaiDAVRSEPVVLVSNTYPD--SGIVSTLLLLEAI-- 76
Cdd:pfam13793   1 LKIFSGNSNPELAEKIAKRLGIPLGKATVSRFSDGEIYVRIE----ESVRGKDVFIIQSTCPPvnDNLMELLIMIDALkr 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 663515100   77 ADVRRgdlsnlkgeepqsmddvgggVFLAIPYYGYSRQDKRFSKGEAVSARVIAEIL 133
Cdd:pfam13793  77 ASAKR--------------------ITAVIPYFGYARQDRKDKPREPITAKLVADLL 113
Pribosyltran pfam00156
Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl ...
 176-263 2.96e-12

Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl transferase enzymes. This family includes: Adenine phosphoribosyl-transferase EC:2.4.2.7. Hypoxanthine-guanine-xanthine phosphoribosyl-transferase. Hypoxanthine phosphoribosyl-transferase EC:2.4.2.8. Ribose-phosphate pyrophosphokinase i EC:2.7.6.1. Amidophosphoribosyltransferase EC:2.4.2.14. Orotate phosphoribosyl-transferase EC:2.4.2.10. Uracil phosphoribosyl-transferase EC:2.4.2.9. Xanthine-guanine phosphoribosyl-transferase EC:2.4.2.22. In Arabidopsis, At the very N-terminus of this domain is the P-Loop NTPase domain.


Pssm-ID: 425489 [Multi-domain]  Cd Length: 150  Bit Score: 63.15  E-value: 2.96e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100  176 SPDFVLSPDKGAISRATEVAGLIGCDFSYLEKTR-IDAHTIEHTPKDL--DVGGKVVAIVDDMISTGGTICRASDALRRQ 252
Cdd:pfam00156  29 KPDVVVGILRGGLPFAGILARRLDVPLAFVRKVSyNPDTSEVMKTSSAlpDLKGKTVLIVDDILDTGGTLLKVLELLKNV 108

                          90
                  ....*....|.
gi 663515100  253 GATEVHAACTH 263
Cdd:pfam00156 109 GPKEVKIAVLI 119
Pribosyl_synth pfam14572
Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes ...
 223-288 2.62e-07

Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes from class EC:2.7.6.1, phosphoribosyl-pyrophosphate transferase.


Pssm-ID: 434046  Cd Length: 184  Bit Score: 49.82  E-value: 2.62e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 663515100  223 DVGGKVVAIVDDMISTGGTICRASDALRRQGATEVHAACTHGLFTGGAILRL-ANHVDGVHSTDSLP 288
Cdd:pfam14572  80 DVGGRIAIIVDDMIDDVDSFVAAAELLKERGAYKIYVMATHGLLSSDAPRLLeASPIDEVVVTNTIP 146
PyrE COG0461
Orotate phosphoribosyltransferase [Nucleotide transport and metabolism]; Orotate ...
 161-277 3.10e-07

Orotate phosphoribosyltransferase [Nucleotide transport and metabolism]; Orotate phosphoribosyltransferase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440229  Cd Length: 201  Bit Score: 49.77  E-value: 3.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100 161 VSSMPEIAELL---------QSEVSPDFVLSPDKGAISRATEVAGLIGCDFSYLEKTRID---AHTIEHTPKDldvgGKV 228
Cdd:COG0461   39 VLSYPEALELLgealaelikELGPEFDAVAGPATGGIPLAAAVARALGLPAIFVRKEAKDhgtGGQIEGGLLP----GER 114

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 663515100 229 VAIVDDMISTGGTICRASDALRRQGATEVHAACthgLFT--GGAILRLANH 277
Cdd:COG0461  115 VLVVEDVITTGGSVLEAVEALREAGAEVVGVAV---IVDreEGAAENLEEA 162
PLN02297 PLN02297
ribose-phosphate pyrophosphokinase
 220-305 3.32e-07

ribose-phosphate pyrophosphokinase


Pssm-ID: 177934 [Multi-domain]  Cd Length: 326  Bit Score: 50.84  E-value: 3.32e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100 220 KDLDVGGKVVAIVDDMISTGGTICRASDALRRQGATEVHAACTHGLFTGGAILRLaNHVDGVHS--------TDSLPN-- 289
Cdd:PLN02297 224 KEGNPAGRHVVIVDDLVQSGGTLIECQKVLAAHGAAKVSAYVTHGVFPNESWERF-THDNGGPEagfayfwiTDSCPQtv 302

                         90       100
                 ....*....|....*....|...
gi 663515100 290 -------PRAVVSAAPALARGLQ 305
Cdd:PLN02297 303 kavrgkaPFEVLSLAGSIADALQ 325
pyrE PRK00455
orotate phosphoribosyltransferase; Validated
 166-261 8.67e-07

orotate phosphoribosyltransferase; Validated


Pssm-ID: 234771  Cd Length: 202  Bit Score: 48.61  E-value: 8.67e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100 166 EIAELLQ-SEVSPDFVLSPDKGAISRATEVAGLIGCDFSYLEKTridahtiehtPKDLDVG---------GKVVAIVDDM 235
Cdd:PRK00455  53 FLAEAIKdSGIEFDVVAGPATGGIPLAAAVARALDLPAIFVRKE----------AKDHGEGgqiegrrlfGKRVLVVEDV 122

                         90       100
                 ....*....|....*....|....*.
gi 663515100 236 ISTGGTICRASDALRRQGATEVHAAC 261
Cdd:PRK00455 123 ITTGGSVLEAVEAIRAAGAEVVGVAV 148
PRK02304 PRK02304
adenine phosphoribosyltransferase; Provisional
 226-261 1.69e-05

adenine phosphoribosyltransferase; Provisional


Pssm-ID: 235028  Cd Length: 175  Bit Score: 44.30  E-value: 1.69e-05
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 663515100 226 GKVVAIVDDMISTGGTICRASDALRRQGATEVHAAC 261
Cdd:PRK02304 114 GDRVLIVDDLLATGGTLEAAIKLLERLGAEVVGAAF 149
PRK02277 PRK02277
orotate phosphoribosyltransferase-like protein; Provisional
 164-262 1.74e-05

orotate phosphoribosyltransferase-like protein; Provisional


Pssm-ID: 235023 [Multi-domain]  Cd Length: 200  Bit Score: 44.86  E-value: 1.74e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100 164 MPEIAELLQSEVspDFVLSPDKGAISRATEVAGLIGCDFSYLEKTRIDAHTIEHTPKDL-----DVGGKVVAIVDDMIST 238
Cdd:PRK02277  75 MADMLEKEDEEV--DVVVGIAKSGVPLATLVADELGKDLAIYHPKKWDHGEGEKKTGSFsrnfaSVEGKRCVIVDDVITS 152

                         90       100
                 ....*....|....*....|....
gi 663515100 239 GGTICRASDALRRQGATEVhaACT 262
Cdd:PRK02277 153 GTTMKETIEYLKEHGGKPV--AVV 174
upp PRK00129
uracil phosphoribosyltransferase; Reviewed
 219-261 2.28e-05

uracil phosphoribosyltransferase; Reviewed


Pssm-ID: 234653  Cd Length: 209  Bit Score: 44.69  E-value: 2.28e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 663515100 219 PKDLDvgGKVVAIVDDMISTGGTICRASDALRRQGATEVHAAC 261
Cdd:PRK00129 119 PEDID--ERTVIVVDPMLATGGSAIAAIDLLKKRGAKNIKVLC 159
PRK11595 PRK11595
DNA utilization protein GntX; Provisional
 198-261 3.23e-05

DNA utilization protein GntX; Provisional


Pssm-ID: 183221 [Multi-domain]  Cd Length: 227  Bit Score: 44.26  E-value: 3.23e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 663515100 198 IGCDFSYLEKTRIDAHTIEHTPK--------------DLDVGGKVVAIVDDMISTGGTICRASDALRRQGATEVHAAC 261
Cdd:PRK11595 145 LGCDYDSEALTRTRATATQHFLSarlrkrnlknafrlELPVQGQHMAIVDDVVTTGSTVAEIAQLLLRNGAASVQVWC 222
PLN02293 PLN02293
adenine phosphoribosyltransferase
 226-265 1.05e-04

adenine phosphoribosyltransferase


Pssm-ID: 177930  Cd Length: 187  Bit Score: 42.35  E-value: 1.05e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 663515100 226 GKVVAIVDDMISTGGTICRASDALRRQGATEVHAACTHGL 265
Cdd:PLN02293 125 GERALVIDDLIATGGTLCAAINLLERAGAEVVECACVIEL 164
pyrE TIGR00336
orotate phosphoribosyltransferase; Orotate phosphoribosyltransferase (OPRTase) is involved in ...
 167-255 2.22e-03

orotate phosphoribosyltransferase; Orotate phosphoribosyltransferase (OPRTase) is involved in the biosynthesis of pyrimidine nucleotides. Alpha-D-ribosyldiphosphate 5-phosphate (PRPP) and orotate are utilized to form pyrophosphate and orotidine 5'-monophosphate (OMP) in the presence of divalent cations, preferably Mg2+. In a number of eukaryotes, this protein is fused to a domain that catalyses the reaction (EC 4.1.1.23). The combined activity of EC 2.4.2.10 and EC 4.1.1.23 is termed uridine 5'-monophosphate synthase. The conserved Lys (K) residue at position 101 of the seed alignment has been proposed as the active site for the enzyme. [Purines, pyrimidines, nucleosides, and nucleotides, Pyrimidine ribonucleotide biosynthesis]


Pssm-ID: 129436 [Multi-domain]  Cd Length: 173  Bit Score: 38.18  E-value: 2.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100  167 IAELLQSEVSPDFVLSPDKGAISRATEVagligCDFSYLEKTRIDAHTIEHTPKDLDVGGKV---------VAIVDDMIS 237
Cdd:TIGR00336  45 AAAIIKSHLEFDVIAGPALGGIPIATAV-----SVKLAKPGGDIPLCFNRKEAKDHGEGGNIegellegdkVVVVEDVIT 119

                          90
                  ....*....|....*...
gi 663515100  238 TGGTICRASDALRRQGAT 255
Cdd:TIGR00336 120 TGTSILEAVEIIQAAGGQ 137
PRK07322 PRK07322
adenine phosphoribosyltransferase; Provisional
 165-264 2.30e-03

adenine phosphoribosyltransferase; Provisional


Pssm-ID: 180928  Cd Length: 178  Bit Score: 38.42  E-value: 2.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515100 165 PEIAELLQSEVspDFVLSPDKGAISRATEVAGLIGCDFSYLEKTR----IDAHTIE------HTPKDL-----DV---GG 226
Cdd:PRK07322  43 EALAKRLPTEV--DVLVTPETKGIPLAHALSRRLGKPYVVARKSRkpymQDPIIQEvvsittGKPQLLvldgaDAeklKG 120

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 663515100 227 KVVAIVDDMISTGGTICRASDALRRQGATEVH--AACTHG 264
Cdd:PRK07322 121 KRVAIVDDVVSTGGTLTALERLVERAGGQVVAkaAIFAEG 160
PRK05793 PRK05793
amidophosphoribosyltransferase; Provisional
 224-258 4.85e-03

amidophosphoribosyltransferase; Provisional


Pssm-ID: 235611 [Multi-domain]  Cd Length: 469  Bit Score: 38.48  E-value: 4.85e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 663515100 224 VGGKVVAIVDDMISTGGTICRASDALRRQGATEVH 258
Cdd:PRK05793 351 VEGKRVVLIDDSIVRGTTSKRLVELLRKAGAKEVH 385
Apt COG0503
Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein [Nucleotide ...
 226-261 6.81e-03

Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein [Nucleotide transport and metabolism]; Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein is part of the Pathway/BioSystem: Purine salvage


Pssm-ID: 440269  Cd Length: 171  Bit Score: 36.59  E-value: 6.81e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 663515100 226 GKVVAIVDDMISTGGTICRASDALRRQGATEVHAAC 261
Cdd:COG0503  112 GDRVLIVDDLLATGGTAKAAIKLVEEAGAEVVGIAF 147
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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