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Conserved domains on  [gi|663515107|gb|AIF05597|]
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4-hydroxybenzoate polyprenyltransferase (ubiA) [uncultured marine group II/III euryarchaeote KM3_185_F04]

Protein Classification

4-hydroxybenzoate octaprenyltransferase( domain architecture ID 10195474)

4-hydroxybenzoate octaprenyltransferase catalyzes the conversion of 4-hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate in a Mg2+-sensitive manner

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PT_UbiA_COQ2 cd13959
4-Hydroxybenzoate polyprenyltransferase; 4-Hydroxybenzoate polyprenyltransferase, also known ...
 7-308 3.38e-54

4-Hydroxybenzoate polyprenyltransferase; 4-Hydroxybenzoate polyprenyltransferase, also known as Coq2, catalyzes the prenylation of p-hydroxybenzoate with an all-trans polyprenyl group, an important step in ubiquinone (CoQ) biosynthesis. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


:

Pssm-ID: 260122 [Multi-domain]  Cd Length: 272  Bit Score: 178.04  E-value: 3.38e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107   7 LEFVKVEHTLFSLPFVLIGFVLADREFGSQSM-DLVWIIVAAIGARGLAMALNRIIDREIDAENPRTASRHLPSGTISNR 85
Cdd:cd13959    1 MRLDKPIGTLLLLPPALWGLLLAAGGLPLPLLkLLLLFLLGAFLMRSAGCTINDIADRDIDAKVPRTKNRPLASGAISVK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107  86 AAWMLSAAFLGMLLFAAWRLNEVALKMAWLPVLAFVAYPYTKRVSWICHFWIGLCLALAPAGawvaisadtlGWAAITGM 165
Cdd:cd13959   81 EALLFLAVQLLLGLALLLQLNPLTILLSPIALLLVLIYPLMKRFTYWPQLVLGLAFGWGPLM----------GWAAVTGS 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107 166 FDggteflwyPELFFISLGVALWITAFDINYARMDVDVDREQGIRSFPASYGNQATMGLSVALTIGwLACFLLTGMheFT 245
Cdd:cd13959  151 LP--------LPALLLYLAVIFWTAGYDTIYAHQDREDDRKIGVKSTAVLFGDRTKLILALLLHLF-VALLLLAGG--LA 219

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 663515107 246 DRRGFRYTLWVPAVLLMALINILVMTRGAQAAtesdeamrgfqKTLFRASMFTGWALLASLMF 308
Cdd:cd13959  220 GLGWPYYLGLGAAAHLLWQEHRLDLPDPLRSC-----------LAFFLSNGWVGLLLFAGLLL 271
 
Name Accession Description Interval E-value
PT_UbiA_COQ2 cd13959
4-Hydroxybenzoate polyprenyltransferase; 4-Hydroxybenzoate polyprenyltransferase, also known ...
 7-308 3.38e-54

4-Hydroxybenzoate polyprenyltransferase; 4-Hydroxybenzoate polyprenyltransferase, also known as Coq2, catalyzes the prenylation of p-hydroxybenzoate with an all-trans polyprenyl group, an important step in ubiquinone (CoQ) biosynthesis. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260122 [Multi-domain]  Cd Length: 272  Bit Score: 178.04  E-value: 3.38e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107   7 LEFVKVEHTLFSLPFVLIGFVLADREFGSQSM-DLVWIIVAAIGARGLAMALNRIIDREIDAENPRTASRHLPSGTISNR 85
Cdd:cd13959    1 MRLDKPIGTLLLLPPALWGLLLAAGGLPLPLLkLLLLFLLGAFLMRSAGCTINDIADRDIDAKVPRTKNRPLASGAISVK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107  86 AAWMLSAAFLGMLLFAAWRLNEVALKMAWLPVLAFVAYPYTKRVSWICHFWIGLCLALAPAGawvaisadtlGWAAITGM 165
Cdd:cd13959   81 EALLFLAVQLLLGLALLLQLNPLTILLSPIALLLVLIYPLMKRFTYWPQLVLGLAFGWGPLM----------GWAAVTGS 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107 166 FDggteflwyPELFFISLGVALWITAFDINYARMDVDVDREQGIRSFPASYGNQATMGLSVALTIGwLACFLLTGMheFT 245
Cdd:cd13959  151 LP--------LPALLLYLAVIFWTAGYDTIYAHQDREDDRKIGVKSTAVLFGDRTKLILALLLHLF-VALLLLAGG--LA 219

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 663515107 246 DRRGFRYTLWVPAVLLMALINILVMTRGAQAAtesdeamrgfqKTLFRASMFTGWALLASLMF 308
Cdd:cd13959  220 GLGWPYYLGLGAAAHLLWQEHRLDLPDPLRSC-----------LAFFLSNGWVGLLLFAGLLL 271
ubiA_other TIGR01475
putative 4-hydroxybenzoate polyprenyltransferase; A fairly deep split separates this ...
 3-265 5.20e-54

putative 4-hydroxybenzoate polyprenyltransferase; A fairly deep split separates this polyprenyltransferase subfamily from the set of mitochondrial and proteobacterial 4-hydroxybenzoate polyprenyltransferases, described in TIGR01474. Protoheme IX farnesyltransferase (heme O synthase) (TIGR01473) is more distantly related. Because no species appears to have both this protein and a member of TIGR01474, it is likely that this model represents 4-hydroxybenzoate polyprenyltransferase, a critical enzyme of ubiquinone biosynthesis, in the Archaea, Gram-positive bacteria, Aquifex aeolicus, the Chlamydias, etc. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273646  Cd Length: 282  Bit Score: 177.93  E-value: 5.20e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107    3 VRDVLEFVKVEHTLFSLPFVLIGFVLADREFGSQSMdLVWIIVAAIGARGLAMALNRIIDREIDAENPRTASRHLPSGTI 82
Cdd:TIGR01475   2 FKDILELIKFEHTVFALPFAYAGALLAAKGLPGLKT-LILILIAAVSARTAAMAFNRIIDRAIDARNPRTKNRPLVSGLI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107   83 SNRAAWMLSAAFLGMLLFAAWRLNEVALKMAWLPVLAFVAYPYTKRVSWICHFWIGLCLALAPAGawvaisadtlGWAAI 162
Cdd:TIGR01475  81 SKKEARTMIILSLALFLSASYFLNPLAFILSPLVLLVLIIYPYTKRFTFLCHYVLGSTYGLAPLA----------GWVAV 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107  163 TGMFDggteFLWYPELFFIslGVALWITAFDINYARMDVDVDREQGIRSFPASYGNQATMGLSVALTIGWLACFLLTGmh 242
Cdd:TIGR01475 151 IGTIS----FFLVAWLLGI--GVGFWIAGFDLIYAIQDYEFDRKNGLHSIPARFGIKAALKIASLSHVITFILLLLVG-- 222

                         250       260
                  ....*....|....*....|...
gi 663515107  243 eFTDRRGFRYTLwvpAVLLMALI 265
Cdd:TIGR01475 223 -FYVGNGYIALL---ALILIGLI 241
ubiA PRK12886
prenyltransferase; Reviewed
 7-241 1.45e-50

prenyltransferase; Reviewed


Pssm-ID: 237247  Cd Length: 291  Bit Score: 169.10  E-value: 1.45e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107   7 LEFVKVEHTLFSLPFVLIGFVLADREFGSQSMdLVWIIVAAIGARGLAMALNRIIDREIDAENPRTASRHLPSGTISNRA 86
Cdd:PRK12886  12 LEMIKFSHTLFALPFAGIGAVLAALGLPGASQ-LDWILMAMVGARTAAMGFNRLIDAEIDARNPRTAGRAIPAGLISKGS 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107  87 AWMLSAAFLGMLLFAAWRLNEVALKMAWLPVLAFVAYPYTKRVSWICHFWIGLCLALAPAGAWVAISaDTLGWAAItgmf 166
Cdd:PRK12886  91 AILFIVLSSLLMLFAAWFLNPLCLYLSPPALFFLLLYSYCKRFTALAHVVLGFCLALAPLGAWIAIR-GTIELPAI---- 165

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 663515107 167 dggtefLWypelffiSLGVALWITAFDINYARMDVDVDREQGIRSFPASYGNQATMGLSVALTIgwLACFLLTGM 241
Cdd:PRK12886 166 ------LL-------GLAVLFWVAGFDILYALQDLEFDRKEGLHSIPAKLGVNGSLWIARVFHL--LMIGFLFAL 225
MqnP_SCO4491 NF041584
menaquinone biosynthesis prenyltransferase MqnP, SCO4491 family; This model is one of three ...
 3-217 8.23e-44

menaquinone biosynthesis prenyltransferase MqnP, SCO4491 family; This model is one of three built to describe UbiA-like prenyltransferases thought to be menaquinone biosynthesis prenyltransferase MqnP. This family contains the founding protein SCO4491.


Pssm-ID: 469469  Cd Length: 285  Bit Score: 151.37  E-value: 8.23e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107   3 VRDVLEFVKVEHTLFSLPFVLIGFVLADREFGSQS--MDLVWIIVAAIGARGLAMALNRIIDREIDAENPRTASRHLPSG 80
Cdd:NF041584   3 VRAFLRLVMIEHSVFALPFAYIAALTAMFLADRSVhwGDLLLVTVAMVGLRTFAMAANRIIDREIDARNPRTAGRELVTG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107  81 TISNRAAWMLSAAFLGMLLFAAWRLNEVALKMAWLPVLAFVAYPYTKRVSWICHFWIGLCLALAPAGAWVAISaDTLGWA 160
Cdd:NF041584  83 AVSVRTAWTGALVALVVFLGAAALLNPLCLALAPVAVVPMVVYPYGKRFTNFPHAILGLAQAIGPIGAWLAVT-GTWSWD 161

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 663515107 161 AItgmfdggteflwypelfFISLGVALWITAFDINYARMDVDVDREQGIRSFPASYG 217
Cdd:NF041584 162 AV-----------------LLGLAVGVWIGGFDLIYACQDVEADRAIGVRSVPARFG 201
UbiA pfam01040
UbiA prenyltransferase family;
18-272 3.62e-29

UbiA prenyltransferase family;


Pssm-ID: 460038 [Multi-domain]  Cd Length: 250  Bit Score: 111.94  E-value: 3.62e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107   18 SLPFVLIGFVLADREFGSQSMdLVWIIVAAIGARGLAMALNRIIDREIDAENPRTASRHLPSGTISNRAAWMLSAAFLGM 97
Cdd:pfam01040   1 LLIPALAGLALAAGGVPDLLL-LLLALLGTVLARAAANALNDYYDRDIDAIMPRTPNRPLPSGRISPREALIFALVLLAL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107   98 LLFAAWRLNEVALKMAWLPVLAFVAYP-YTKRVSWICHFWIGLCLALAPAgawvaisadtLGWAAITGMFDggteflwyP 176
Cdd:pfam01040  80 GLLLLLLLNPLTALLGLAALLLYVLYTlRLKRRTLLGQLVGGLAFGLPPL----------LGWAAVTGSLS--------P 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107  177 ELFFISLGVALWITAFDINYARMDVDVDREQGIRSFPASYGNQATMGLSVALTIGWLACFLLTGMHEFTdrrGFRYTLWV 256
Cdd:pfam01040 142 LALLLALALFLWTWAIALANDLRDREDDRKAGIKTLPVVLGRKAARILLALLLAVALLLLLLLLLLLLG---GLYLLLAL 218

                         250
                  ....*....|....*.
gi 663515107  257 PAVLLMALINILVMTR 272
Cdd:pfam01040 219 LLAALALLYAARLLRL 234
UbiA COG0382
4-hydroxybenzoate polyprenyltransferase [Coenzyme transport and metabolism]; 4-hydroxybenzoate ...
 16-308 1.37e-21

4-hydroxybenzoate polyprenyltransferase [Coenzyme transport and metabolism]; 4-hydroxybenzoate polyprenyltransferase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440151  Cd Length: 280  Bit Score: 92.21  E-value: 1.37e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107  16 LFSLPFVLIGFVLADreFGSQSMDLVWIIVAAIGARGLAMALNRIIDREIDAENPRTASRHLPSGTISNRAAWMLSAAFL 95
Cdd:COG0382   17 LLLWPTLWALFLAAG--GLPDLLLLLLAVLGTVLMRSAGYVINDYFDREIDRINERKPNRPLASGRISLREALLLAIVLL 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107  96 GMLLFAAWRLNEVALKMAWLPVLAFVAYP-YTKRVSWICHFWIGLclalapAGAWVAIsadtLGWAAITGMFDggteflw 174
Cdd:COG0382   95 LLALALALLLNPLTFLLALAALALAWAYSlFLKRFTLLGNLVLGL------LFGLGIL----MGFAAVTGSLP------- 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107 175 yPELFFISLGVALWITAFDINYARMDVDVDREQGIRSFPASYGNQATMGLSVALTIGWLACFLLTGMHEftdrrGFRYTL 254
Cdd:COG0382  158 -LSAWLLALAAFLWTLAYDTIYDLEDREGDRKIGIKTLAILFGVRDALIIAGVLYALAVLLLLLLGLLA-----GLGLLY 231

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 663515107 255 WVPAVLLMALINILVMTRGAQAATESDEAMRgfqktLFRASMFTGWALLASLMF 308
Cdd:COG0382  232 LLGLLAALLLLYLSQLWLLRPRKKDPARALK-----LFKLNMLLGLLLFLGIAL 280
 
Name Accession Description Interval E-value
PT_UbiA_COQ2 cd13959
4-Hydroxybenzoate polyprenyltransferase; 4-Hydroxybenzoate polyprenyltransferase, also known ...
 7-308 3.38e-54

4-Hydroxybenzoate polyprenyltransferase; 4-Hydroxybenzoate polyprenyltransferase, also known as Coq2, catalyzes the prenylation of p-hydroxybenzoate with an all-trans polyprenyl group, an important step in ubiquinone (CoQ) biosynthesis. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260122 [Multi-domain]  Cd Length: 272  Bit Score: 178.04  E-value: 3.38e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107   7 LEFVKVEHTLFSLPFVLIGFVLADREFGSQSM-DLVWIIVAAIGARGLAMALNRIIDREIDAENPRTASRHLPSGTISNR 85
Cdd:cd13959    1 MRLDKPIGTLLLLPPALWGLLLAAGGLPLPLLkLLLLFLLGAFLMRSAGCTINDIADRDIDAKVPRTKNRPLASGAISVK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107  86 AAWMLSAAFLGMLLFAAWRLNEVALKMAWLPVLAFVAYPYTKRVSWICHFWIGLCLALAPAGawvaisadtlGWAAITGM 165
Cdd:cd13959   81 EALLFLAVQLLLGLALLLQLNPLTILLSPIALLLVLIYPLMKRFTYWPQLVLGLAFGWGPLM----------GWAAVTGS 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107 166 FDggteflwyPELFFISLGVALWITAFDINYARMDVDVDREQGIRSFPASYGNQATMGLSVALTIGwLACFLLTGMheFT 245
Cdd:cd13959  151 LP--------LPALLLYLAVIFWTAGYDTIYAHQDREDDRKIGVKSTAVLFGDRTKLILALLLHLF-VALLLLAGG--LA 219

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 663515107 246 DRRGFRYTLWVPAVLLMALINILVMTRGAQAAtesdeamrgfqKTLFRASMFTGWALLASLMF 308
Cdd:cd13959  220 GLGWPYYLGLGAAAHLLWQEHRLDLPDPLRSC-----------LAFFLSNGWVGLLLFAGLLL 271
ubiA_other TIGR01475
putative 4-hydroxybenzoate polyprenyltransferase; A fairly deep split separates this ...
 3-265 5.20e-54

putative 4-hydroxybenzoate polyprenyltransferase; A fairly deep split separates this polyprenyltransferase subfamily from the set of mitochondrial and proteobacterial 4-hydroxybenzoate polyprenyltransferases, described in TIGR01474. Protoheme IX farnesyltransferase (heme O synthase) (TIGR01473) is more distantly related. Because no species appears to have both this protein and a member of TIGR01474, it is likely that this model represents 4-hydroxybenzoate polyprenyltransferase, a critical enzyme of ubiquinone biosynthesis, in the Archaea, Gram-positive bacteria, Aquifex aeolicus, the Chlamydias, etc. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273646  Cd Length: 282  Bit Score: 177.93  E-value: 5.20e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107    3 VRDVLEFVKVEHTLFSLPFVLIGFVLADREFGSQSMdLVWIIVAAIGARGLAMALNRIIDREIDAENPRTASRHLPSGTI 82
Cdd:TIGR01475   2 FKDILELIKFEHTVFALPFAYAGALLAAKGLPGLKT-LILILIAAVSARTAAMAFNRIIDRAIDARNPRTKNRPLVSGLI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107   83 SNRAAWMLSAAFLGMLLFAAWRLNEVALKMAWLPVLAFVAYPYTKRVSWICHFWIGLCLALAPAGawvaisadtlGWAAI 162
Cdd:TIGR01475  81 SKKEARTMIILSLALFLSASYFLNPLAFILSPLVLLVLIIYPYTKRFTFLCHYVLGSTYGLAPLA----------GWVAV 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107  163 TGMFDggteFLWYPELFFIslGVALWITAFDINYARMDVDVDREQGIRSFPASYGNQATMGLSVALTIGWLACFLLTGmh 242
Cdd:TIGR01475 151 IGTIS----FFLVAWLLGI--GVGFWIAGFDLIYAIQDYEFDRKNGLHSIPARFGIKAALKIASLSHVITFILLLLVG-- 222

                         250       260
                  ....*....|....*....|...
gi 663515107  243 eFTDRRGFRYTLwvpAVLLMALI 265
Cdd:TIGR01475 223 -FYVGNGYIALL---ALILIGLI 241
ubiA PRK12886
prenyltransferase; Reviewed
 7-241 1.45e-50

prenyltransferase; Reviewed


Pssm-ID: 237247  Cd Length: 291  Bit Score: 169.10  E-value: 1.45e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107   7 LEFVKVEHTLFSLPFVLIGFVLADREFGSQSMdLVWIIVAAIGARGLAMALNRIIDREIDAENPRTASRHLPSGTISNRA 86
Cdd:PRK12886  12 LEMIKFSHTLFALPFAGIGAVLAALGLPGASQ-LDWILMAMVGARTAAMGFNRLIDAEIDARNPRTAGRAIPAGLISKGS 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107  87 AWMLSAAFLGMLLFAAWRLNEVALKMAWLPVLAFVAYPYTKRVSWICHFWIGLCLALAPAGAWVAISaDTLGWAAItgmf 166
Cdd:PRK12886  91 AILFIVLSSLLMLFAAWFLNPLCLYLSPPALFFLLLYSYCKRFTALAHVVLGFCLALAPLGAWIAIR-GTIELPAI---- 165

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 663515107 167 dggtefLWypelffiSLGVALWITAFDINYARMDVDVDREQGIRSFPASYGNQATMGLSVALTIgwLACFLLTGM 241
Cdd:PRK12886 166 ------LL-------GLAVLFWVAGFDILYALQDLEFDRKEGLHSIPAKLGVNGSLWIARVFHL--LMIGFLFAL 225
ubiA PRK12888
4-hydroxybenzoate octaprenyltransferase;
3-240 3.07e-50

4-hydroxybenzoate octaprenyltransferase;


Pssm-ID: 183814  Cd Length: 284  Bit Score: 168.36  E-value: 3.07e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107   3 VRDVLEFVKVEHTLFSLPFVLIGFVLADREFGS--QSMDLVWIIVAAIGARGLAMALNRIIDREIDAENPRTASRHLPSG 80
Cdd:PRK12888   2 VRAFLRLVAIEHSVFALPFAYIAALTAMFASDGsvHWADLLLVTVAMVGARTFAMAANRIIDREIDARNPRTAGRELVTG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107  81 TISNRAAWMLSAAFLGMLLFAAWRLNEVALKMAWLPVLAFVAYPYTKRVSWICHFWIGLCLALAPAGAWVAISAdTLGWA 160
Cdd:PRK12888  82 AVSVRTAWTGALVALAVFLGAAALLNPLCLALAPLAVAPLVVYPYAKRFTNFPHAILGLAQAVGPVGAWIAVTG-TWSWP 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107 161 AItgmfdggteflwypelfFISLGVALWITAFDINYARMDVDVDREQGIRSFPASYGNQATMGLSVALTIGWLACFLLTG 240
Cdd:PRK12888 161 AV-----------------LLGLAVGLWIGGFDLIYACQDAEVDRRIGVRSVPARFGVRAALWASRVAHVVTFALFVWFG 223
MqnP_SCO4491 NF041584
menaquinone biosynthesis prenyltransferase MqnP, SCO4491 family; This model is one of three ...
 3-217 8.23e-44

menaquinone biosynthesis prenyltransferase MqnP, SCO4491 family; This model is one of three built to describe UbiA-like prenyltransferases thought to be menaquinone biosynthesis prenyltransferase MqnP. This family contains the founding protein SCO4491.


Pssm-ID: 469469  Cd Length: 285  Bit Score: 151.37  E-value: 8.23e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107   3 VRDVLEFVKVEHTLFSLPFVLIGFVLADREFGSQS--MDLVWIIVAAIGARGLAMALNRIIDREIDAENPRTASRHLPSG 80
Cdd:NF041584   3 VRAFLRLVMIEHSVFALPFAYIAALTAMFLADRSVhwGDLLLVTVAMVGLRTFAMAANRIIDREIDARNPRTAGRELVTG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107  81 TISNRAAWMLSAAFLGMLLFAAWRLNEVALKMAWLPVLAFVAYPYTKRVSWICHFWIGLCLALAPAGAWVAISaDTLGWA 160
Cdd:NF041584  83 AVSVRTAWTGALVALVVFLGAAALLNPLCLALAPVAVVPMVVYPYGKRFTNFPHAILGLAQAIGPIGAWLAVT-GTWSWD 161

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 663515107 161 AItgmfdggteflwypelfFISLGVALWITAFDINYARMDVDVDREQGIRSFPASYG 217
Cdd:NF041584 162 AV-----------------LLGLAVGVWIGGFDLIYACQDVEADRAIGVRSVPARFG 201
ubiA PRK12874
4-hydroxybenzoate polyprenyltransferase;
3-236 4.23e-38

4-hydroxybenzoate polyprenyltransferase;


Pssm-ID: 237242  Cd Length: 291  Bit Score: 136.68  E-value: 4.23e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107   3 VRDVLEFVKVEHTLFSLPFVLIGFVLA------DREFGSQSmdLVWIIVAAIGARGLAMALNRIIDREIDAENPRTASRH 76
Cdd:PRK12874   8 LKDISELVVFKHSIFSLPFIFIAMIVAskqkndTGWFGFKL--LILGILAAVSARNFAMAFNRLVDRDIDKDNPRTANRP 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107  77 LPSGTISNRAAWMLSAAFLGMLLFAAWRLNEVALKMAwLPVLAFVA-YPYTKRVSWICHFWIGLCLALAPAGAWVAISAD 155
Cdd:PRK12874  86 SVDGRISVKSMVLFIVLNALIFIGVSYFINPLAFKLS-FPFLIVLGgYSYFKRFSSLAHLVLGLSLGLAPIAGVVAVLGE 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107 156 TLGWAaitgmfdggteflwypelFFISLGVALWITAFDINYARMDVDVDREQGIRSFPASYGNQATMGLSV---ALTIGW 232
Cdd:PRK12874 165 IPLWS------------------VFLALGVMFWVAGFDLLYSLQDMEFDKKRGLHSIPSKFGEKATLFISRlfhLLAVLF 226


                 ....
gi 663515107 233 LACF 236
Cdd:PRK12874 227 WLLF 230
ubiA PRK13106
prenyltransferase; Reviewed
 7-274 5.23e-35

prenyltransferase; Reviewed


Pssm-ID: 237283  Cd Length: 300  Bit Score: 128.69  E-value: 5.23e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107   7 LEFVKVEHTLFSLPFVLIGFVLADREFGSQSmDLVWIIVAAIGARGLAMALNRIIDREIDAENPRTASRHLPSGTISNRA 86
Cdd:PRK13106  19 LRFLRIEQTFFSLPMAYLGAFVAIKGIPPIS-TLILIFLALFFLRTAGMTNDNLADLEIDAKNPRTKNRPLVTGAIKISE 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107  87 AWMLSAAFLGMLLFAAWRLNEVALKMAWLPVLAFVAYPYTKRVSWICHFWIGLCLALAPAGAWVAISadtlgwaaitGMF 166
Cdd:PRK13106  98 AKALITAGLILFFASAYLVNRWALLLSPIVALIAMSYPYMKRYTAFANYHLASIQGLAVFSGAVAVL----------GLY 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107 167 DGGTEFLWY--PELFFIslGVALWITAFDINYARMDVDVDREQGIRSFPASYGNQAtmgLSVALTIGWLACFLLTGMHEF 244
Cdd:PRK13106 168 ANSLIQVLLrvPWLFVI--GTILWAAGFDLYNHIPDAEFDREMGLHSFAVVLGKWA---LTFAGLNQLFSVVLDLLGDLY 242

                        250       260       270
                 ....*....|....*....|....*....|
gi 663515107 245 TDRRGFRYTLWVPAVLLMALINILVMTRGA 274
Cdd:PRK13106 243 YGLGPIAIAATILHGLIMAYAYYLASKKGD 272
ubiA PRK12895
prenyltransferase; Reviewed
 1-307 1.40e-30

prenyltransferase; Reviewed


Pssm-ID: 237251  Cd Length: 286  Bit Score: 116.84  E-value: 1.40e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107   1 MEVRDVLEFVKVEHTLFSLPFVLIGFVLADREFgSQSMDLVWIIVAAIGARGLAMALNRIIDREIDAENPRTASRHLPSG 80
Cdd:PRK12895   1 MNFRDIVDYIKLEHTVFDLPFILAGYVIAAGHY-IHPIKILLILIAAVSARTSAMSINRIEGLRYDMINPRKKDWALVSG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107  81 TISNRAAWMLSAAFLGMLLFAAWRLNEVALKMAWLPVLAFVAYPYTKRVSWICHFWIGLCLALAPAGAWVAISAdtlgwa 160
Cdd:PRK12895  80 RIKMREAIAFTIIFIAIFEICTFLLNRLVFILSPIVIFLFIIDPFLKRYTAWRHIYMGSIIGLGVLAGYLAVIP------ 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107 161 aitgmfdggtEFLWYPELFFISLGVALWITAFDINYARMDVDVDREQGIRSFPASYGNQATMGLSVALTIGWLACFLLTG 240
Cdd:PRK12895 154 ----------AFPYNLLIYIIFISSSLWIAGFDIIYVIPDIEYDKINGLKTIMNTYGIKNGLYISDIFHISSLILFWISG 223

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 663515107 241 MHeftdrrgFRyTLWVPAVLLmaLINILVMTRGAQAATESDEAMRgfqKTLFRASMFTGWALLASLM 307
Cdd:PRK12895 224 IY-------IR-TLWYLAALI--IIYTLVIYQHLIIDPRNPINKR---MSFFNANSFIGFVFLIGII 277
UbiA pfam01040
UbiA prenyltransferase family;
18-272 3.62e-29

UbiA prenyltransferase family;


Pssm-ID: 460038 [Multi-domain]  Cd Length: 250  Bit Score: 111.94  E-value: 3.62e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107   18 SLPFVLIGFVLADREFGSQSMdLVWIIVAAIGARGLAMALNRIIDREIDAENPRTASRHLPSGTISNRAAWMLSAAFLGM 97
Cdd:pfam01040   1 LLIPALAGLALAAGGVPDLLL-LLLALLGTVLARAAANALNDYYDRDIDAIMPRTPNRPLPSGRISPREALIFALVLLAL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107   98 LLFAAWRLNEVALKMAWLPVLAFVAYP-YTKRVSWICHFWIGLCLALAPAgawvaisadtLGWAAITGMFDggteflwyP 176
Cdd:pfam01040  80 GLLLLLLLNPLTALLGLAALLLYVLYTlRLKRRTLLGQLVGGLAFGLPPL----------LGWAAVTGSLS--------P 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107  177 ELFFISLGVALWITAFDINYARMDVDVDREQGIRSFPASYGNQATMGLSVALTIGWLACFLLTGMHEFTdrrGFRYTLWV 256
Cdd:pfam01040 142 LALLLALALFLWTWAIALANDLRDREDDRKAGIKTLPVVLGRKAARILLALLLAVALLLLLLLLLLLLG---GLYLLLAL 218

                         250
                  ....*....|....*.
gi 663515107  257 PAVLLMALINILVMTR 272
Cdd:pfam01040 219 LLAALALLYAARLLRL 234
ubiA PRK12876
prenyltransferase; Reviewed
 1-306 5.46e-27

prenyltransferase; Reviewed


Pssm-ID: 237244  Cd Length: 300  Bit Score: 107.52  E-value: 5.46e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107   1 MEVRDVLEFVKVEHTLFSLPFV----LIGFVLADREFGSQSMDLVWIIV----AAIGARGLAMALNRIIDREIDAENPRT 72
Cdd:PRK12876   2 MRIKYFQQLINCKYALFSALFLsastVFALSLPEISFSLFSLGGIKTISlggsAFFCARTVGIIVNQIIDCAIDKKNPRT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107  73 ASRHLPSGTISNRAAWMLSAAFLGMLLFAAWRLNEVALKMAWLPVLAFVAYPYTKRVSWICHFWIGLCLALAPAGAWVAI 152
Cdd:PRK12876  82 SSRVLPAKLLSINFSMLLLTLCSFLFLSLCWLLNPLCFSLAVLSTLLMIIYPYTKRVTFLCHWILGLVYYLAILMNFFAI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107 153 SADTLGWaaitgmfdggteflwypELFFIS----LGVALWITAFDINYARMDVDVDREQGIRSFPASYG-NQATMGLSVA 227
Cdd:PRK12876 162 IETPLSF-----------------SLFCMAslwgISFGMIIAANDIIYAIQDLEFDRKEGLFSIPARFGeKKAIRIASAN 224

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 663515107 228 LTIGWLAcFLLTGMHEFTDRRGFrytlwvpavlLMALINILVMTRGAQAATESDEAMRGFQKTLFRASMFTGWALLASL 306
Cdd:PRK12876 225 LIASAIA-YLLIGYFVSNKKIFY----------LCSLVPLTVILKTIKHYSLIDKKKSTLEQKFFLGNIYLALSFFVNM 292
UbiA COG0382
4-hydroxybenzoate polyprenyltransferase [Coenzyme transport and metabolism]; 4-hydroxybenzoate ...
 16-308 1.37e-21

4-hydroxybenzoate polyprenyltransferase [Coenzyme transport and metabolism]; 4-hydroxybenzoate polyprenyltransferase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440151  Cd Length: 280  Bit Score: 92.21  E-value: 1.37e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107  16 LFSLPFVLIGFVLADreFGSQSMDLVWIIVAAIGARGLAMALNRIIDREIDAENPRTASRHLPSGTISNRAAWMLSAAFL 95
Cdd:COG0382   17 LLLWPTLWALFLAAG--GLPDLLLLLLAVLGTVLMRSAGYVINDYFDREIDRINERKPNRPLASGRISLREALLLAIVLL 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107  96 GMLLFAAWRLNEVALKMAWLPVLAFVAYP-YTKRVSWICHFWIGLclalapAGAWVAIsadtLGWAAITGMFDggteflw 174
Cdd:COG0382   95 LLALALALLLNPLTFLLALAALALAWAYSlFLKRFTLLGNLVLGL------LFGLGIL----MGFAAVTGSLP------- 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107 175 yPELFFISLGVALWITAFDINYARMDVDVDREQGIRSFPASYGNQATMGLSVALTIGWLACFLLTGMHEftdrrGFRYTL 254
Cdd:COG0382  158 -LSAWLLALAAFLWTLAYDTIYDLEDREGDRKIGIKTLAILFGVRDALIIAGVLYALAVLLLLLLGLLA-----GLGLLY 231

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 663515107 255 WVPAVLLMALINILVMTRGAQAATESDEAMRgfqktLFRASMFTGWALLASLMF 308
Cdd:COG0382  232 LLGLLAALLLLYLSQLWLLRPRKKDPARALK-----LFKLNMLLGLLLFLGIAL 280
PT_UbiA cd13956
UbiA family of prenyltransferases (PTases); Many characterized members of the UbiA ...
 7-303 6.37e-16

UbiA family of prenyltransferases (PTases); Many characterized members of the UbiA prenyltransferase family are aromatic prenyltransferases and play an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K. They contain two copies of a motif similar to the active site DxxD motif of trans-prenyltransferases and are potentially related. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260119 [Multi-domain]  Cd Length: 271  Bit Score: 76.23  E-value: 6.37e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107   7 LEFVKVEHTLFSLPFVLIGFVLADREFGSQSMDLVWIIVAAIGARGLAMALNRIIDREIDAENprTASRHLPSGTISNRA 86
Cdd:cd13956    1 LRLMRPYTLLYVLAPALAGAALAGAFAGPLPALLLLALLAVFLGAGAGYALNDYTDRELDAIN--KPDRPLPSGRLSPRQ 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107  87 AWMLSAAFLGMLLFAAWRLNEVALKMAWLPVLAFVAYPYTKRVSWICH-FWIGLCLALAPAGAWVAISADTLGWAAItgm 165
Cdd:cd13956   79 ALAFAAALLLVGLALALALGPLALLLLLAGLLLGLAYSLGLKRLKLGGwGVLGYATGLALLPGLGAVAAGGLVPLAL--- 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107 166 fdggteflwypelfFISLGVALWITAFDINYARMDVDVDREQGIRSFPASYGNQATMGLSVALtigWLACFLLTGmheFT 245
Cdd:cd13956  156 --------------LLALVFLLLGLGINLYNDLPDVEGDRAAGIRTLPVRLGPRRARRLAAGL---LLAALILVV---LL 215

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 663515107 246 DRRGFRYTLWVPAVLLMALINILVmtRGAQAATESDEAMRGFQKTLFRASMFTGWALL 303
Cdd:cd13956  216 AVAGLLGPLALLALLAVALLALRA--RFARADRLPALPRGFLLLAVYRLLLFAALLLA 271
PT_UbiA_Cox10 cd13957
Protoheme IX farnesyltransferase; Protoheme IX farnesyltransferase (also called heme O ...
 22-162 1.63e-11

Protoheme IX farnesyltransferase; Protoheme IX farnesyltransferase (also called heme O synthase, heme A:farnesyltransferase, cytochrome c oxidase subunit X [Cox10]) converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of the heme B porphyrin ring with a hydroxyethyl farnesyl side group. It is localized at the mitochondrial inner membrane. Eukaryotic Cox10 is important for the maturation of the heme A prosthetic group of cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, that catalyzes the electron transfer from reduced cytochrome c to oxygen. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260120  Cd Length: 271  Bit Score: 63.61  E-value: 1.63e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107  22 VLIGFVLADREFGSqSMDLVWIIVAAIGARGLAMALNRIIDREIDAENPRTASRHLPSGTISNRAAWMLSAA--FLGMLL 99
Cdd:cd13957   16 ALAGYLLAPGGVPD-LLLLLLTLLGTALVSASANALNQYIERDIDAKMKRTRNRPLPSGRISPKHALIFGLVlgILGLAL 94

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 663515107 100 FAAWrLNEVAlkmAWLPVLAFVAY-----PYTKRVSWICHFWIGLCLALAPAGAWVAISaDTLGWAAI 162
Cdd:cd13957   95 LALF-VNPLT---ALLGLLGIFLYvfvytPLKKRTTPLNTVIGGIAGAIPPLIGWAAAT-GSLDLGAW 157
PRK04375 PRK04375
protoheme IX farnesyltransferase; Provisional
 22-167 3.96e-11

protoheme IX farnesyltransferase; Provisional


Pssm-ID: 235293  Cd Length: 296  Bit Score: 62.46  E-value: 3.96e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107  22 VLIGFVLADRefgsqSMDLVWIIVAAIGARGLAM----ALNRIIDREIDAENPRTASRHLPSGTISNRAAWMLSA--AFL 95
Cdd:PRK04375  29 ALGGMLLAPP-----GVPPLLLLLLTLLGIALVAgaagALNNYIDRDIDAKMERTKNRPLVTGRISPREALIFGLvlGVL 103

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 663515107  96 GMLLFAAWrLNEVAlkmAWLPVLAFVAY--PYT---KRVSWICHFWIGLCLALAPAgawvaisadtLGWAAITGMFD 167
Cdd:PRK04375 104 GFLLLGLF-VNPLA---AWLTLAGIFFYvvVYTlwlKRRTPQNIVIGGAAGAMPPL----------IGWAAVTGSLS 166
PLN02776 PLN02776
prenyltransferase
 25-174 9.47e-07

prenyltransferase


Pssm-ID: 215415  Cd Length: 341  Bit Score: 49.74  E-value: 9.47e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107  25 GFVLAdrefGSQSMD---LVWIIVAAIGARGLAMALNRIIDREIDAENPRTASRHLPSG--TISNRAAWMLSAAFLGMLL 99
Cdd:PLN02776  17 GFVLG----SGEAIDlpgLGWTCAGTMLCAASANTLNQVFEVKNDSKMKRTMRRPLPSGriSVPHAVAWAVVVGAAGVAL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107 100 FaAWRLNEV--ALKMAWLPVLAFVaYPYTKRVSWIcHFWIglclalapaGAWVAISADTLGWAAITGMFD------GGTE 171
Cdd:PLN02776  93 L-AYKTNMLtaGLGAGNILLYAFV-YTPLKQIHPA-NTWV---------GAVVGAIPPLMGWAAASGQLDagamvlAAAL 160


                 ...
gi 663515107 172 FLW 174
Cdd:PLN02776 161 YFW 163
PT_UbiA_DGGGPS cd13961
Geranylgeranylglycerol-phosphate geranylgeranyltransferase; Digeranylgeranylglyceryl phosphate ...
 18-230 1.53e-06

Geranylgeranylglycerol-phosphate geranylgeranyltransferase; Digeranylgeranylglyceryl phosphate synthase (DGGGPS) transfers a geranylgeranyl group from geranylgeranyl diphosphate to (S)-3-O-geranylgeranylglyceryl phosphate to form (S)-2,3-di-O-geranylgeranylglyceryl phosphate, as part of the isoprenoid ether lipid biosynthesis. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260124  Cd Length: 270  Bit Score: 48.65  E-value: 1.53e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107  18 SLPFVLIGFVLADREFGSQSMDLVWIIVAAIGARGLAMALNRIIDREIDAEN-PrtaSRHLPSGTISNRAAWMLSAAFLG 96
Cdd:cd13961   15 ALAQYLGALFALGPLLSLNDLELLLLFLSVFLIAAAGYIINDYFDVEIDRINkP---DRPIPSGRISRREALILSILLNA 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107  97 MLLFAAWRLNEVALKMAWLPVLAFVAYPYT-KRVSWICHFWIGLCLALAPAGAWVAisadtlgwaaitgmfdggteflwy 175
Cdd:cd13961   92 LGLILAFLLSPLALLIALLNSLLLWLYSHKlKRTPLIGNLLVALLTGLPFLFGGLA------------------------ 147

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 663515107 176 pELFFISLGVALWITAFDINYAR------MDVDVDREQGIRSFPASYGNQATMGLSVALTI 230
Cdd:cd13961  148 -AGNLLLIILLLALFAFLITLGReivkdiEDVEGDRAEGARTLPIVYGIKKAKKIAALLLL 207
PT_UbiA_1 cd13964
UbiA family of prenyltransferases (PTases), Unknown subgroup; Many characterized members of ...
 22-123 6.20e-06

UbiA family of prenyltransferases (PTases), Unknown subgroup; Many characterized members of the UbiA prenyltransferase family are aromatic prenyltransferases and play an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K. They contain two copies of a motif similar to the active site DxxD motif of trans-prenyltransferases and are potentially related. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways. The function of this subgroup is unknown.


Pssm-ID: 260127  Cd Length: 282  Bit Score: 46.80  E-value: 6.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107  22 VLIGFVLAdREFGSQSMDLVWIIVAAIGARGLAMALNRIIDREIDA-ENPrtaSRHLPSGTISNRAAWMLSAAFLGMLLF 100
Cdd:cd13964   17 VLAGAALA-GGGLGPVLRLALLLLASVLLYAAGMVLNDVFDAELDArERP---ERPIPSGRVSRGAALALGAGLLAAGVA 92

                         90       100
                 ....*....|....*....|...
gi 663515107 101 AAWRLNEVALKMAWLPVLAFVAY 123
Cdd:cd13964   93 LAALVGRLSGLVALLLAAAILLY 115
ubiA PRK12884
prenyltransferase; Reviewed
 1-238 2.14e-05

prenyltransferase; Reviewed


Pssm-ID: 183812  Cd Length: 279  Bit Score: 45.33  E-value: 2.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107   1 MEVRDVLEFVKVEHTLFSLPFVLIGFVLADRefGSQSMDLVWIIVAAIGARGLAMALNRIIDREIDAENprTASRHLPSG 80
Cdd:PRK12884   2 TKMKAYLELLRPEHGLMAGIAVVLGAIIALG--GLPLDEALLGFLTAFFASGSANALNDYFDYEVDRIN--RPDRPIPSG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107  81 TISNRAAWMLSAAFLGMLLFAAWRLNEVALKMAWLPVLAFVAYPYT-KRVSWICHFWIGLCLALapagawvaisadTLGW 159
Cdd:PRK12884  78 RISRREALLLAILLFILGLIAAYLISPLAFLVVILVSVLGILYNWKlKEYGLIGNLYVAFLTGM------------TFIF 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107 160 AAITgmFDGGTEFLWYpeLFFISLGVALwitAFDINYARMDVDVDREQGIRSFPASYGNQATMGLSVAL-TIGWLACFLL 238
Cdd:PRK12884 146 GGIA--VGELNEAVIL--LAAMAFLMTL---GREIMKDIEDVEGDRLRGARTLAILYGEKIAGRIAAALfILAVLLSPLP 218
PRK07566 PRK07566
chlorophyll synthase ChlG;
52-233 3.04e-04

chlorophyll synthase ChlG;


Pssm-ID: 236052  Cd Length: 314  Bit Score: 41.83  E-value: 3.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107  52 GLAMALNRIIDREIDAEN-PrtaSRHLPSGTISNRAAWMLSAAFLGMLLFAAWRLNEVALKMAWLPVlaFVAYPYT---- 126
Cdd:PRK07566  79 GTSQTLNDYFDREVDAINeP---YRPIPSGAISLRWVLYLIAVLTVLGLAVAYLLGPWVFLAALLGL--FLAWIYSappl 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107 127 --KRVSWICHFWIGLC-LALA-PAGAwVAISADTLGW--AAITGMFDGGteflwypelffiSLGVALwitafdINyarmD 200
Cdd:PRK07566 154 rlKQNGWLGNYAVGLSyEGLPwWAGA-AAFGAGLPSWpiVILALLYSLG------------AHGIMT------LN----D 210

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 663515107 201 ---VDVDREQGIRSFPASYGNQ-------ATMGLSVALTIGWL 233
Cdd:PRK07566 211 fksVEGDRQLGLRSLPVVFGEKnaariacVVIDLFQLAVIALL 253
ubiA PRK12882
prenyltransferase; Reviewed
 1-310 3.34e-04

prenyltransferase; Reviewed


Pssm-ID: 183811  Cd Length: 276  Bit Score: 41.50  E-value: 3.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107   1 MEVRDVLEFVKVEHTLFSLPFVLIGFVLADREFGSQSMdLVWIIVAAIGARGLAMALNRIIDREIDAENprTASRHLPSG 80
Cdd:PRK12882   2 MTVRGYLELTRPVNAVVAGVAAFIGAFIAGGILSSPSL-TGLAFAAVFLATGAGNAINDYFDREIDRIN--RPDRPIPSG 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107  81 TISNRAAWMLSAAFLGMLLFAAWRLNEVALKMAWLPVLAFVAYP-YTKRVSwichfWIGLCLALAPAGAWVAISADTLGW 159
Cdd:PRK12882  79 AVSPRGALAFSILLFAAGVALAFLLPPLCLAIALFNSLLLVLYAeTLKGTP-----GLGNASVAYLTGSTFLFGGAAVGT 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107 160 AAITGMFdggteflwypELFFISlgvALWITAFDINYARMDVDVDREQGIRSFPASYGNQATMGLSVA-LTIGWLACFLL 238
Cdd:PRK12882 154 EGLLALL----------VLFALA---ALATLAREIIKDVEDIEGDRAEGARTLPILIGVRKALYVAAAfLLVAVAASPLP 220

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 663515107 239 TGMHEFtdrrGFRY-TLWVPAVLLM--ALINILVMTRGAQAatesdeamrgfqKTLFRASMFtgwalLASLMFVA 310
Cdd:PRK12882 221 YLLSTF----GLWYlVLVAPADLVMlaAAYRSLKKTDPTAS------------QKLLKYGMF-----LALAAFIV 274
PRK09573 PRK09573
(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase; Reviewed
 1-143 1.66e-03

(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase; Reviewed


Pssm-ID: 181963  Cd Length: 279  Bit Score: 39.56  E-value: 1.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107   1 MEVRDVLEFVKVEHTLFSLPFVLIGFVLADR-EFGSQSMDLVWIIVAAIGARGlaMALNRIIDREIDAENprTASRHLPS 79
Cdd:PRK09573   1 MSIKAYFELIRPKNCIGASIGAIIGYLIASNfKIDLKGIILAALVVFLVCAGG--NVINDIYDIEIDKIN--KPERPIPS 76

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 663515107  80 GTISNRAAWMLSAAFLGMLLFAAWRLNEVALKMAWLPVLAFVAYPYT-KRVSWICHFWIGLCLAL 143
Cdd:PRK09573  77 GRISLKEAKIFSITLFIVGLILSIFINIYAFLIALLNSILLYLYAKDlKKTGLIGNLIVAYLTGL 141
PT_UbiA_5 cd13967
UbiA family of prenyltransferases (PTases), Unknown subgroup; Many characterized members of ...
 42-268 6.32e-03

UbiA family of prenyltransferases (PTases), Unknown subgroup; Many characterized members of the UbiA prenyltransferase family are aromatic prenyltransferases and play an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K. They contain two copies of a motif similar to the active site DxxD motif of trans-prenyltransferases and are potentially related. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways. The function of this subgroup is unknown.


Pssm-ID: 260130  Cd Length: 277  Bit Score: 37.59  E-value: 6.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107  42 WIIVAAIGARGLAM-ALNRIIDREIDAENP--RTASrhlpsgTISNRAAWMLSAAFLGMLLFA-AWRLNEVALkmAWLPV 117
Cdd:cd13967   35 LPALLIAGLVVYSVyTLNRLTDSEEDAYNDpeRAAF------YEKYKKLLLALAIAAGLLALAlAFILGLLAF--AILLL 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663515107 118 LAFVAYPYTKRVSWICHFWIGLCLALAPAGAWVAISadtlgWAAITGMFDGGTEFLWYPELFFISLGVAL---WITA-FD 193
Cdd:cd13967  107 PLLLGLLYSLPIKPGKLRLRRRKDIPGSKNLVVALA-----WAVVIALLPALYGQPSTPSVLVVFLFFFLkvfVNTAiFD 181

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 663515107 194 InyarMDVDVDREQGIRSFPASYGNQATMGLSVALTIGwLACFLLTGMheftdrrgfrYTLWVPAVLLMALINIL 268
Cdd:cd13967  182 I----RDVEGDRIVGIETLPVLLGEERTRLLLLVLNIL-LALLLVAGV----------LLGLLASEFLVLLLSLI 241
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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