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Conserved domains on  [gi|671759869|gb|AII98495|]
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NADH dehydrogenase subunit 2 (mitochondrion) [Lemur catta]

Protein Classification

NADH dehydrogenase subunit 2( domain architecture ID 11475899)

NADH dehydrogenase subunit 2 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
1-347 4.74e-154

NADH dehydrogenase subunit 2; Provisional


:

Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 436.20  E-value: 4.74e-154
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869   1 MKPIILMFIMLTIFMGTMLTMISSHWLLMWVGLEINMLAIIPILMKKISPRSTEAATKYFLTQATASMLLMFSIVINTAN 80
Cdd:MTH00105   1 MNPLILIIIYLTLFLGTMITMISSHWLLAWIGLEMNMLAIIPILMKKHNPRSTEAATKYFLTQATASMLLMMAIIINLMY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869  81 SGQWGITNMHNQLTSLVTMAALMMKLGMTPFHFWVPEVTQGISLMSGMLLLTWQKLAPISILLQIFPSMNPNIILLIAIL 160
Cdd:MTH00105  81 SGQWTITKLTNPTASTLMTIALAMKLGLAPFHFWVPEVTQGIPLSSGMILLTWQKLAPLSILYQISPSINPNLLLTLAIL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869 161 SILVGGWGGLNQTQLRKILAYSSIAHMGWMMAILMYCPSLTMLNLLIYLMLTITLFSVLNINTNTTTLTLSNTWNKTPMI 240
Cdd:MTH00105 161 SILIGGWGGLNQTQLRKILAYSSIAHMGWMTAILPYNPTLTLLNLLIYIIMTLTMFMLLMLNSSTTTLSLSHTWNKTPLM 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869 241 TLTILISLLSLGGLPPLTGFLPKWTIIQELTKNSNIMLATIMAIMALLNLYFYMRLIYSTSLTMFPTLNNMKMKWQFQQT 320
Cdd:MTH00105 241 TSLILLTLLSLGGLPPLTGFMPKWMIIQELTKNNNIILPTLMAITALLNLYFYMRLIYSTSLTMFPSTNNMKMKWQFENT 320
                        330       340
                 ....*....|....*....|....*..
gi 671759869 321 KQIFLLSPLVILATLTLPLSPALLTLN 347
Cdd:MTH00105 321 KPMTLLPTLIILSTMLLPLTPMLSILE 347
 
Name Accession Description Interval E-value
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
1-347 4.74e-154

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 436.20  E-value: 4.74e-154
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869   1 MKPIILMFIMLTIFMGTMLTMISSHWLLMWVGLEINMLAIIPILMKKISPRSTEAATKYFLTQATASMLLMFSIVINTAN 80
Cdd:MTH00105   1 MNPLILIIIYLTLFLGTMITMISSHWLLAWIGLEMNMLAIIPILMKKHNPRSTEAATKYFLTQATASMLLMMAIIINLMY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869  81 SGQWGITNMHNQLTSLVTMAALMMKLGMTPFHFWVPEVTQGISLMSGMLLLTWQKLAPISILLQIFPSMNPNIILLIAIL 160
Cdd:MTH00105  81 SGQWTITKLTNPTASTLMTIALAMKLGLAPFHFWVPEVTQGIPLSSGMILLTWQKLAPLSILYQISPSINPNLLLTLAIL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869 161 SILVGGWGGLNQTQLRKILAYSSIAHMGWMMAILMYCPSLTMLNLLIYLMLTITLFSVLNINTNTTTLTLSNTWNKTPMI 240
Cdd:MTH00105 161 SILIGGWGGLNQTQLRKILAYSSIAHMGWMTAILPYNPTLTLLNLLIYIIMTLTMFMLLMLNSSTTTLSLSHTWNKTPLM 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869 241 TLTILISLLSLGGLPPLTGFLPKWTIIQELTKNSNIMLATIMAIMALLNLYFYMRLIYSTSLTMFPTLNNMKMKWQFQQT 320
Cdd:MTH00105 241 TSLILLTLLSLGGLPPLTGFMPKWMIIQELTKNNNIILPTLMAITALLNLYFYMRLIYSTSLTMFPSTNNMKMKWQFENT 320
                        330       340
                 ....*....|....*....|....*..
gi 671759869 321 KQIFLLSPLVILATLTLPLSPALLTLN 347
Cdd:MTH00105 321 KPMTLLPTLIILSTMLLPLTPMLSILE 347
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
23-281 3.62e-18

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 83.52  E-value: 3.62e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869   23 SSHWLLMWVGLEINMLAIIP-ILMKKISPRSTEAATKYFLTQATASMLLMFSIVINTANSGQWGITNMHNQLT------- 94
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLlIGYWGKSPRSSEAGMKYFLLTLLGSSILLFGISLMYNYTGTLSFDELSKALTgglnssg 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869   95 ----SLVTMAALMMKLGMTPFHFWVPEVTQGISLMSGMLLL-TWQKLAPISILLQIFPSMNPNIILLIAILSILV----- 164
Cdd:pfam00361  81 llllFLLILVGFLFKSAQVPFHTWLPDAYEGAPTPVSALLAaTLVKAGGYGLIRRSLLYLPSSPFIQQILLILAIismll 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869  165 GGWGGLNQTQLRKILAYSSIAHMGWMMAILM----YCPSLTMLNLLIYLMLTITLFSVLNINT-----NTTTLTLSNTWN 235
Cdd:pfam00361 161 GSLAALVQTDIKRLLAYSSISHMGYMLIALGagtiYGIQAAIFHLLTHGLFSAGLFLCAGSVIyrrvhTRNIRDYGGLAK 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 671759869  236 KTPMITLTILISLLSLGGLPPLTGFLPKWTIIQELTKNSNIMLATI 281
Cdd:pfam00361 241 TMPILALVFLVAMLSLAGLPPTAGFLGKFLILAAAVAASWIFLVLA 286
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
9-298 3.61e-17

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 82.09  E-value: 3.61e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869   9 IMLTIFMGTMLTMISSHWLLMWVGLEINMLAI-IPILMKKISPRSTEAATKYFLTQATASMLLMFSIVINTANSGQWGIT 87
Cdd:COG1007  107 LLLFATLGMMLMASANDLLTLFLGLELLSLSLyVLVAFRRDDRRSSEAALKYFLLGALSSGFLLYGISLLYGATGSLNLA 186
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869  88 NMHNQLTS------LVTMAALMM------KLGMTPFHFWVPEVTQGISLMSGMLLLTWQKLAPISILLQIFPSMNPNIIL 155
Cdd:COG1007  187 GIAAALAAgganspLLLLGLVLVlaglafKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAALLRLLVEAFPGLAA 266
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869 156 LIAILSI-------LVGGWGGLNQTQLRKILAYSSIAHMGWMMAILMYCPSL----TMLNLLIYLMLTITLFSVLNINTN 224
Cdd:COG1007  267 DWQLLLAvlavlsmTVGNLAALAQTNVKRMLAYSSIAHAGYLLLGLAAGTPLgvsaALFYLLAYLFMNLGAFAVILLLSR 346
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 671759869 225 TTTLTLSN-----TWNKTPMITLTILISLLSLGGLPPLTGFLPKWTIIQELTKNSNIMLATIMAIMALLNLYFYMRLIY 298
Cdd:COG1007  347 KGGEAEEIedlagLARRSPLLALAMTIFLLSLAGIPPTAGFFGKFYVFSAAVEAGLYWLAVIAVLNSVISAYYYLRVVK 425
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
9-297 1.51e-15

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 77.30  E-value: 1.51e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869    9 IMLTIFMGTMLTMISSHWLLMWVGLEINMLAI-IPILMKKISPRSTEAATKYFLTQATASMLLMFSIVINTANSGQWGIT 87
Cdd:TIGR01770 107 LLLFALLGIFLLVSSNDLLSIYLGLELQSLCFyVLAGLKRKSRFSTEAGLKYFILGAFSSGLLLFGISLIYGFTGSLNFE 186
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869   88 NMHNQLTS------------LVTMAALMMKLGMTPFHFWVPEVTQGISLMSGMLLLTWQKLAPISILLQIFPSM------ 149
Cdd:TIGR01770 187 DLLLFLSNgmlnisllllgiVLILVGLLFKLSAVPFHMWVPDVYEGAPTPVTAFFSIVPKIAIFAVFLRLFLYIlfgfse 266
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869  150 -NPNIILLIAILSILVGGWGGLNQTQLRKILAYSSIAHMGWMMAILMyCPSLTMLNLLIYLMLTITLFSVLNINTNTTTL 228
Cdd:TIGR01770 267 aWQIFLAIIAFLSMLIGNFGALAQKKVKRLLAYSSISHVGYILIGLL-AGTLEGIKAVLFYIFIYALMSLGAFGVLSLLR 345
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869  229 TLSNTWNKT-----------PMITLTILISLLSLGGLPPLTGFLPKWTIIQELTKNSNIMLATIMAIMALLNLYFYMRLI 297
Cdd:TIGR01770 346 SYKDEWIEYisdfaglfktnPILAILILIFMFSLAGIPPLAGFFGKFYVFFALLKSGLYWLAVIAVLTSVIGAFYYLRVV 425
 
Name Accession Description Interval E-value
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
1-347 4.74e-154

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 436.20  E-value: 4.74e-154
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869   1 MKPIILMFIMLTIFMGTMLTMISSHWLLMWVGLEINMLAIIPILMKKISPRSTEAATKYFLTQATASMLLMFSIVINTAN 80
Cdd:MTH00105   1 MNPLILIIIYLTLFLGTMITMISSHWLLAWIGLEMNMLAIIPILMKKHNPRSTEAATKYFLTQATASMLLMMAIIINLMY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869  81 SGQWGITNMHNQLTSLVTMAALMMKLGMTPFHFWVPEVTQGISLMSGMLLLTWQKLAPISILLQIFPSMNPNIILLIAIL 160
Cdd:MTH00105  81 SGQWTITKLTNPTASTLMTIALAMKLGLAPFHFWVPEVTQGIPLSSGMILLTWQKLAPLSILYQISPSINPNLLLTLAIL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869 161 SILVGGWGGLNQTQLRKILAYSSIAHMGWMMAILMYCPSLTMLNLLIYLMLTITLFSVLNINTNTTTLTLSNTWNKTPMI 240
Cdd:MTH00105 161 SILIGGWGGLNQTQLRKILAYSSIAHMGWMTAILPYNPTLTLLNLLIYIIMTLTMFMLLMLNSSTTTLSLSHTWNKTPLM 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869 241 TLTILISLLSLGGLPPLTGFLPKWTIIQELTKNSNIMLATIMAIMALLNLYFYMRLIYSTSLTMFPTLNNMKMKWQFQQT 320
Cdd:MTH00105 241 TSLILLTLLSLGGLPPLTGFMPKWMIIQELTKNNNIILPTLMAITALLNLYFYMRLIYSTSLTMFPSTNNMKMKWQFENT 320
                        330       340
                 ....*....|....*....|....*..
gi 671759869 321 KQIFLLSPLVILATLTLPLSPALLTLN 347
Cdd:MTH00105 321 KPMTLLPTLIILSTMLLPLTPMLSILE 347
ND2 MTH00135
NADH dehydrogenase subunit 2; Provisional
1-346 1.83e-110

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177193 [Multi-domain]  Cd Length: 347  Bit Score: 325.61  E-value: 1.83e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869   1 MKPIILMFIMLTIFMGTMLTMISSHWLLMWVGLEINMLAIIPILMKKISPRSTEAATKYFLTQATASMLLMFSIVINTAN 80
Cdd:MTH00135   1 MNPYVLTILLFSLGLGTTLTFASSHWLLAWMGLEINTLAIIPLMAQHHHPRAVEATTKYFLTQATAAAMILFASTTNAWL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869  81 SGQWGITNMHNQLTSLVTMAALMMKLGMTPFHFWVPEVTQGISLMSGMLLLTWQKLAPISILLQIFPSmNPNIILLIAIL 160
Cdd:MTH00135  81 TGQWDIQQMSHPLPTTMITLALALKIGLAPLHFWLPEVLQGLDLTTGLILSTWQKLAPFALILQIAPT-NPTLLITLGLT 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869 161 SILVGGWGGLNQTQLRKILAYSSIAHMGWMMAILMYCPSLTMLNLLIYLMLTITLFSVLNINTNTTTLTLSNTWNKTPMI 240
Cdd:MTH00135 160 STLVGGWGGLNQTQLRKILAYSSIAHLGWMILVLQFSPSLTLLALLTYIIMTSSAFLTFKLNSSTKINTLATSWTKAPAL 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869 241 TLTILISLLSLGGLPPLTGFLPKWTIIQELTKNSNIMLATIMAIMALLNLYFYMRLIYSTSLTMFPTLNNMKMKWQFQQT 320
Cdd:MTH00135 240 TALTPLILLSLGGLPPLTGFMPKWLILQELTKQDLPLTATLAALSALLSLYFYLRLSYAMTLTISPNTLNGTTPWRLPST 319
                        330       340
                 ....*....|....*....|....*.
gi 671759869 321 KQIFLLSPLVILATLTLPLSPALLTL 346
Cdd:MTH00135 320 QLTLPLAISTTATLMLLPLTPAILAL 345
ND2 MTH00112
NADH dehydrogenase subunit 2; Provisional
1-346 6.72e-106

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214423 [Multi-domain]  Cd Length: 346  Bit Score: 314.07  E-value: 6.72e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869   1 MKPIILMFIMLTIFMGTMLTMISSHWLLMWVGLEINMLAIIPILMKKISPRSTEAATKYFLTQATASMLLMFSIVINTAN 80
Cdd:MTH00112   1 MNPHAKLIITTSLILGTIITISSNHWLMAWTGLEINTLAIIPLISKPHHPRATEAATKYFLTQAAASALILFSSTTNAWN 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869  81 SGQWGITNMHNQLTSLVTMAALMMKLGMTPFHFWVPEVTQGISLMSGMLLLTWQKLAPISILLQIFPSMNPNIILLIAIL 160
Cdd:MTH00112  81 TGQWDITQLTNPTSCTLLTLALAMKLGLAPFHFWLPEVLQGSTTTTALILSTWQKLAPLTLLLMTSNSLNPTLLLTLAIL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869 161 SILVGGWGGLNQTQLRKILAYSSIAHMGWMMAILMYCPSLTMLNLLIYLMLTITLFSVLNINTNTTTLTLSNTWNKTPMI 240
Cdd:MTH00112 161 STLIGGWGGLNQTQLRKIMAFSSIAHLGWMIAIITYSPKLTLLTFYIYILMTTPMFLTLNTTSTKTLKDMMTSWTKSPTL 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869 241 TLTILISLLSLGGLPPLTGFLPKWTIIQELTKNSNIMLATIMAIMALLNLYFYMRLIYSTSLTMFPTLNNMKMKWQFQQT 320
Cdd:MTH00112 241 NTTLMLTLLSLAGLPPLTGFMPKWLILQELTKQNMTPTATIMAMLSLLSLFFYLRLTYISTITLPPNTTNMMMKWRTKPK 320
                        330       340
                 ....*....|....*....|....*.
gi 671759869 321 KQIfLLSPLVILATLTLPLSPALLTL 346
Cdd:MTH00112 321 KNT-LTATLTTLSTLLLPLSPMILTI 345
ND2 MTH00070
NADH dehydrogenase subunit 2; Provisional
1-346 1.75e-101

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177142 [Multi-domain]  Cd Length: 346  Bit Score: 302.61  E-value: 1.75e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869   1 MKPIILMFIMLTIFMGTMLTMISSHWLLMWVGLEINMLAIIPILMKKISPRSTEAATKYFLTQATASMLLMFSIVINTAN 80
Cdd:MTH00070   1 MSPYALSILLSSLALGTMITLSSNHWFLAWMGLEINTLAIIPLMTKTHHPRATEAATKYFLTQASASALILFSSTINAWF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869  81 SGQWGITNMHNQLTSLVTMAALMMKLGMTPFHFWVPEVTQGISLMSGMLLLTWQKLAPISILLQIFPSMNPNIILLIAIL 160
Cdd:MTH00070  81 TGEWTIMNMQTPLPTIMLTIALMMKLGIAPFHFWLPEVLQGLDLTTGLILSTWQKLAPMALLIQISHLLNSNLLIIMGLL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869 161 SILVGGWGGLNQTQLRKILAYSSIAHMGWMMAILMYCPSLTMLNLLIYLMLTITLFSVLNINTNTTTLTLSNTWNKTPMI 240
Cdd:MTH00070 161 STLIGGWGGLNQTQLRKIMAYSSIAHLGWMIIILTFSPHLTLLNLLIYLIMTSSMFLMLMNLNSTNINKLSSSWSKNPTL 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869 241 TLTILISLLSLGGLPPLTGFLPKWTIIQELTKNSNIMLATIMAIMALLNLYFYMRLIYSTSLTMFPTLNNMKMKWQFqQT 320
Cdd:MTH00070 241 TSMMMLTLLSLGGLPPTTGFIPKWLILQELTKQNLTTLATLMALSALLSLFFYLRLSYAMSLTTSPNTSNSKLYWRF-KN 319
                        330       340
                 ....*....|....*....|....*.
gi 671759869 321 KQIFLLSPLVILATLTLPLSPALLTL 346
Cdd:MTH00070 320 KTNNLLSLTIILSLMLLPITPTILNL 345
ND2 MTH00200
NADH dehydrogenase subunit 2; Provisional
1-346 1.13e-74

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177246 [Multi-domain]  Cd Length: 347  Bit Score: 234.09  E-value: 1.13e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869   1 MKPIILMFIMLTIFMGTMLTMISSHWLLMWVGLEINMLAIIPILMKKISPRSTEAATKYFLTQATASMLLMFSIVINTAN 80
Cdd:MTH00200   1 MSPLILPLFILSLGLGTLLTFSSSHWFLIWLGLEINTLAIIPLLIKQHHPRKVEATTKYFIIQATASALLLFGGLLNAWT 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869  81 SGQWGITNMHNQLTSLVTMAALMMKLGMTPFHFWVPEVTQGISLMSGMLLLTWQKLAPISILLQIFPSMNPNIILLIAIL 160
Cdd:MTH00200  81 SGQWGISEMLGPLSETLILLALALKLGLAPGHFWVPDVLQGLSLQTGLILSTWQKLAPFALLIQLAPALNSNILLLLGLL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869 161 SILVGGWGGLNQTQLRKILAYSSIAHMGWMMAILMYCPSLTMLNLLIYLMLTITLFSVLNINTNTTTLTLSNTWNKTPMI 240
Cdd:MTH00200 161 SVLVGGWGGLNQTQLRKILAYSSIAHLGWLLSGLVYSPNLALLYLLLYVIITLTVFLLLNLLNSTKINSLSSSKTKNPIL 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869 241 TLTILISLLSLGGLPPLTGFLPKWTIIQELTKNSNIMLATIMAIMALLNLYFYMRLIYSTSLTMFPTLNNMKMKWQFQQT 320
Cdd:MTH00200 241 SMLLGLTLLSLGGLPPLTGFFPKWLILQELSKQGLFIYATILLLGSLLSLFFYLRLSYLTLLTLSPNQINMMSSWRTKSN 320
                        330       340
                 ....*....|....*....|....*.
gi 671759869 321 KqIFLLSPLVILATLTLPLSPALLTL 346
Cdd:MTH00200 321 S-NLLVGLLLLLSILGLPLTPQLLFL 345
ND2 MTH00041
NADH dehydrogenase subunit 2; Validated
1-339 8.75e-72

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 177116 [Multi-domain]  Cd Length: 349  Bit Score: 226.74  E-value: 8.75e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869   1 MKPIILMFIMLTIFMGTMLTMISSHWLLMWVGLEINMLAIIPILMKKISPRSTEAATKYFLTQATASMLLMFSIVINTAN 80
Cdd:MTH00041   1 MNRNVLIFLITSIILGTIIVISSNHWFLIWLGLELNTLSIIPILSSNFSPRSVEATIKYFLVQAFSAAILLNGALIQAWL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869  81 SGQWGITNMHNQLTSLVTMAALMMKLGMTPFHFWVPEVTQGISLMSGMLLLTWQKLAPISILLQIFPSMNPNIILLIAIL 160
Cdd:MTH00041  81 SGSWSINGPLNTLSSIIITLALALKLGLAPCHFWFPDVLQGLPFLQGLIIATWQKIAPLILLISISNLLNSNILILCGIL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869 161 SILVGGWGGLNQTQLRKILAYSSIAHMGWMMAILMYCPSLTMLNLLIYLMLTITLFSVLNINTNTTTLTLSNTWNKTPMI 240
Cdd:MTH00041 161 SVLVGGWGGLNQTQTRKILAFSSIAHLGWIIITSAYSPNASIIMFLIYIIINTSIFLIGNNFSLSTLSHLNKLSQLNPIS 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869 241 TLTILISLLSLGGLPPLTGFLPKWTIIQELTKNSNIMLATIMAIMALLNLYFYMRLIYSTSLTMFPTLNNMKMKWQFQQT 320
Cdd:MTH00041 241 AFLFILSILSLGGLPPLTGFLNKFISLYCLIQNNSILISIILIIGSLLSLFFYLRISFNTSLTLFPQHSISLFSWRNSGN 320
                        330       340
                 ....*....|....*....|....
gi 671759869 321 KQIF-----LLSPLVILATLTLPL 339
Cdd:MTH00041 321 ITVYgvilsILSSISILGLLLIPL 344
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
1-339 1.42e-44

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 155.75  E-value: 1.42e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869   1 MKPIILMFIMLTIFMGTMLTMISSHWLLMWVGLEINMLAIIPILMKKISPRSTEAATKYFLTQATASMLLMFSIVINTAN 80
Cdd:MTH00160   2 MMNSSKLLFLSTLIMGTLISISSNSWFGAWMGLEINLLSFIPLISNKKNLMSSESSLKYFLIQALASIILLFSIILNMLN 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869  81 SgqwgitNMHNQLTSLVTMAALMMKLGMTPFHFWVPEVTQGISLMSGMLLLTWQKLAPISILLQIfpsMNPNIILLIAIL 160
Cdd:MTH00160  82 L------MLFNNISSMLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYL---INNNFIIIIIIL 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869 161 SILVGGWGGLNQTQLRKILAYSSIAHMGWMMAILMYCPSLTMLNLLIYLMLTITLFSVLNINTNTTTLTLSNTWNKTPMI 240
Cdd:MTH00160 153 SAIIGAIGGLNQTSLRKILAYSSINHLGWMLSSMMISENLWLIYFLIYSIISLSIILLFNKFNIFFLNQLFNSNNKSKKI 232
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869 241 TLTILISLLSLGGLPPLTGFLPKWTIIQELTKNSNIMLATIMAIMALLNLYFYMRLIYSTSLTMFPTLNNMKMKWQFQQT 320
Cdd:MTH00160 233 KFLLFLNLLSLGGLPPFLGFLPKWIIIQLLISNNMFFLLFILIMSSLITLYFYLRISYSSLMLNYNKNKWNLKKKKNKFS 312
                        330
                 ....*....|....*....
gi 671759869 321 KQIFLLSPLVILATLTLPL 339
Cdd:MTH00160 313 LILNFLSFISLFGLILSSL 331
ND2 MTH00144
NADH dehydrogenase subunit 2; Provisional
6-315 1.56e-43

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214432 [Multi-domain]  Cd Length: 328  Bit Score: 152.73  E-value: 1.56e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869   6 LMFIMLtIFMGTMLTMISSHWLLMWVGLEINMLAIIPILMKKISPRSTEAATKYFLTQATASMLLMFSIVINTANSGQWG 85
Cdd:MTH00144   7 LLFLFL-MVMGTLLSLSSSHWLGVWVGLEINLIGFLPLLVYKKKSSESESVVKYFIIQSLGSSLLIFGSLIMYNLSFSWF 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869  86 ItnmhnqltSLVTMAALMMKLGMTPFHFWVPEVTQGISLMSGMLLLTWQKLAPISILLQIFPSMNPNIILLIA-ILSILV 164
Cdd:MTH00144  86 S--------MSLLLLGLCLKLGLFPFHFWVPSVMAGLSWLSCFLLLTWQKVAPLFLLSNFLDLYWLAYLLCVIsVLSALV 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869 165 GGWGGLNQTQLRKILAYSSIAHMGWMMAILMYCPSLTMLNLLIYLMLTITLFSVLNINTNTTTLTLSNTwNKTPMITLTI 244
Cdd:MTH00144 158 GSIGGLNQTQVRALLAYSSISHTGWMLVAILHGSWLMWMYFLIYIVSSGFLFFSLWSGDSGSMKDLGSL-KPSYKTGLSI 236
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 671759869 245 LISLLSLGGLPPLTGFLPKWTIIQELTKNSNIMLATIMAIMALLNLYFYMRLIYSTSLTMFPTLNNMKMKW 315
Cdd:MTH00144 237 ISLLLSLGGLPPFLGFCSKLLVLISSMESSPLLLILLLLLGSLISLFFYLSVFFSSFLSSSKSKKSNSSKV 307
ND2 MTH00011
NADH dehydrogenase subunit 2; Validated
6-312 2.04e-39

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 164587 [Multi-domain]  Cd Length: 330  Bit Score: 142.23  E-value: 2.04e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869   6 LMFIMLTIFMGTMLTMISSHWLLMWVGLEINMLAIIPILMKKISPRSTEAATKYFLTQATASMLLMfsivinTANSGQWG 85
Cdd:MTH00011   8 MFLFSSTMTLGTLMALSSNNWLFLWMGMELNLLSFVPLMTSSKMNQESEAAVKYFLAQALGSGLLL------LGMTMMWS 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869  86 ITNMHNQLTSLVTMAALMMKLGMTPFHFWVPEVTQGISLMSGMLLLTWQKLAPISILLQIFPSMNPNIILLIAILSILVG 165
Cdd:MTH00011  82 FPSLLKNITALMLLVSLMLKLGMAPCHFWFPSVMSSISWTLCLILSTWQKIAPLSILFFFTSHNILPMMTSMAAMSALAG 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869 166 GWGGLNQTQLRKILAYSSIAHMGWMMAILMYCPSLTMLNLLIYLMLTITLFSVLNINTNTTTLTLSNTWNKTPMITLTIL 245
Cdd:MTH00011 162 GLGGMNQTQLRPLLAYSSIGHMGWMTMISVFSPSMAILYFMTYIIITTPLMLLFAYLNAFSTKFNSKISSMSQTTSMSLF 241
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 671759869 246 ISLLSLGGLPPLTGFLPKWTIIQELTKNSNIMLATIMAIMALLNLYFYMRLIYStSLTMFPTLNNMK 312
Cdd:MTH00011 242 IMLLSLGGLPPFTGFMPKLMAIETLTSNSMILILLVLIVGSLMNLFYYLNLIFN-FMYLSPTFSSLK 307
ND2 MTH00197
NADH dehydrogenase subunit 2; Provisional
7-332 8.70e-34

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177244 [Multi-domain]  Cd Length: 323  Bit Score: 126.71  E-value: 8.70e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869   7 MFIMLTIFMGTMLTMISSHWLLMWVGLEINMLAIIPILMKKISPRSTEAATKYFLTQATASMLLMFSIVINTANsgqwgi 86
Cdd:MTH00197   1 FLFLFIIFGGVLFSLSSSNWFLVWIGMELNLIGFIPLLSQNKSITENEGAMKYFLFQEFGSALLLMGGSLSFSN------ 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869  87 tNMHNQLTSLVTMAALMMKLGMTPFHFWVPEVTQGISLMSGMLLLTWQKLAPISILlqIFPSMNPNIILLIAILSILVGG 166
Cdd:MTH00197  75 -LYLSLLSVVLVILGLLLKLGAFPFHFWVPSVMESLSWFNCFLLATWQKLAPLLIL--AFNSSSFMGLLICSVLSSLIGG 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869 167 WGGLNQTQLRKILAYSSIAHMGWMMAILMYCPSLTMLNLLIYLMLTITLFSVLNINTNTTTLTLSNTWNKTPMITLTILI 246
Cdd:MTH00197 152 IGGMNQSNIRQLLAYSSIGHTGWMLMSLVYSPSIFMLYYLIYFVIMFMLFLFLSKNNLSSLNQQYSNPESMSSNLVFLGL 231
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869 247 SLLSLGGLPPLTGFLPKWTIIQELTKNSNIMLATIMAIMALLNLYFYMRLIYSTSLTMFPTLNNMKMKWQFQQTKQIFLL 326
Cdd:MTH00197 232 SFLSLGGLPPLSGFFLKWLILTSLLSSNISLITFMLILSTCFSLYYYLSLAYKSLILSNWMINFLMKINLLYSGLFILLM 311

                 ....*.
gi 671759869 327 SPLVIL 332
Cdd:MTH00197 312 MMLPLL 317
ND2 MTH00199
NADH dehydrogenase subunit 2; Provisional
9-218 4.63e-20

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177245 [Multi-domain]  Cd Length: 460  Bit Score: 90.85  E-value: 4.63e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869   9 IMLTIFMGTMLTMISSHWLLMWVGLEINMLAI-IPILMKKISPRSTEAATKYFLTQATASMLLMFSIVINTANSGQWGIT 87
Cdd:MTH00199 102 LILIVALGSLLLVSSINWLSIYLAIELQTLTLfILVALKRDSAYSTEAGLKYFVLGAVSSGLFLFGCALLYGLTGETSIQ 181
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869  88 NMHNQLTS-----LVTMAaLMMKLGMTPFHFWVPEVTQGISLMSGMLLLTWQKLAPISILLQIFPSMNpnIILLIAILSI 162
Cdd:MTH00199 182 GINSILTGdvgkiLITIS-LLFKLSAAPFHMWAPDVYEGAPTITTALLATVPKIGVFSILVQIGPVTN--VVLICAVLSI 258
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 671759869 163 LVGGWGGLNQTQLRKILAYSSIAHMGWMM------------AILMYcpsltmlnLLIYLMLTITLFSV 218
Cdd:MTH00199 259 IYGAIGALNQTKIKRLLAYSGIGHMGFILfgvaigsfesiqASLIY--------MIIYVIMSICSFSI 318
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
23-281 3.62e-18

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 83.52  E-value: 3.62e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869   23 SSHWLLMWVGLEINMLAIIP-ILMKKISPRSTEAATKYFLTQATASMLLMFSIVINTANSGQWGITNMHNQLT------- 94
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLlIGYWGKSPRSSEAGMKYFLLTLLGSSILLFGISLMYNYTGTLSFDELSKALTgglnssg 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869   95 ----SLVTMAALMMKLGMTPFHFWVPEVTQGISLMSGMLLL-TWQKLAPISILLQIFPSMNPNIILLIAILSILV----- 164
Cdd:pfam00361  81 llllFLLILVGFLFKSAQVPFHTWLPDAYEGAPTPVSALLAaTLVKAGGYGLIRRSLLYLPSSPFIQQILLILAIismll 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869  165 GGWGGLNQTQLRKILAYSSIAHMGWMMAILM----YCPSLTMLNLLIYLMLTITLFSVLNINT-----NTTTLTLSNTWN 235
Cdd:pfam00361 161 GSLAALVQTDIKRLLAYSSISHMGYMLIALGagtiYGIQAAIFHLLTHGLFSAGLFLCAGSVIyrrvhTRNIRDYGGLAK 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 671759869  236 KTPMITLTILISLLSLGGLPPLTGFLPKWTIIQELTKNSNIMLATI 281
Cdd:pfam00361 241 TMPILALVFLVAMLSLAGLPPTAGFLGKFLILAAAVAASWIFLVLA 286
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
9-298 3.61e-17

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 82.09  E-value: 3.61e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869   9 IMLTIFMGTMLTMISSHWLLMWVGLEINMLAI-IPILMKKISPRSTEAATKYFLTQATASMLLMFSIVINTANSGQWGIT 87
Cdd:COG1007  107 LLLFATLGMMLMASANDLLTLFLGLELLSLSLyVLVAFRRDDRRSSEAALKYFLLGALSSGFLLYGISLLYGATGSLNLA 186
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869  88 NMHNQLTS------LVTMAALMM------KLGMTPFHFWVPEVTQGISLMSGMLLLTWQKLAPISILLQIFPSMNPNIIL 155
Cdd:COG1007  187 GIAAALAAgganspLLLLGLVLVlaglafKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAALLRLLVEAFPGLAA 266
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869 156 LIAILSI-------LVGGWGGLNQTQLRKILAYSSIAHMGWMMAILMYCPSL----TMLNLLIYLMLTITLFSVLNINTN 224
Cdd:COG1007  267 DWQLLLAvlavlsmTVGNLAALAQTNVKRMLAYSSIAHAGYLLLGLAAGTPLgvsaALFYLLAYLFMNLGAFAVILLLSR 346
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 671759869 225 TTTLTLSN-----TWNKTPMITLTILISLLSLGGLPPLTGFLPKWTIIQELTKNSNIMLATIMAIMALLNLYFYMRLIY 298
Cdd:COG1007  347 KGGEAEEIedlagLARRSPLLALAMTIFLLSLAGIPPTAGFFGKFYVFSAAVEAGLYWLAVIAVLNSVISAYYYLRVVK 425
ND2 MTH00196
NADH dehydrogenase subunit 2; Provisional
13-297 2.95e-16

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214453 [Multi-domain]  Cd Length: 365  Bit Score: 78.92  E-value: 2.95e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869  13 IFMGTMLTMISSHWLLMWVGLEINMLAI-IPILMKKISPRSTEAATKYFLTQATASMLLMFSIV-------------INT 78
Cdd:MTH00196   2 VALGILCLISSSNWLSVYLAIELQTLSLfILIAQNRGSGYSAEAGLKYFVLGALSSGLFLFGCAllcgttgglhlsyINL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869  79 ANSGQWGITNMHNQLTSLVTMAALMMKLGMTPFHFWVPEVTQGISLMSGMLLLTWQKLAPISILLQIFPsmNPNIILLIA 158
Cdd:MTH00196  82 VLNSGQSFSSVSVPIGYLLIIVALLFKLSVAPFHMWAPDVYEGAPTKTTALLAIVPKLGIFSILVSIGL--NVNILLIGG 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869 159 ILSILVGGWGGLNQTQLRKILAYSSIAHMGWMM------------AILMYcpsltmlnLLIYLMLTITLFSVLNINTNTT 226
Cdd:MTH00196 160 LFSLFVGAIGALNQTKIKRLLAYSGIGHMGFVLwgieigsfesiqASLVY--------LFIYIIMSICVFSIILALNVYK 231
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 671759869 227 TLTLSN--TWNKTPMITLTILISLLSLGGLPPLTGFLPKWTIIQELTKNSNIMLATIMAIMALLNLYFYMRLI 297
Cdd:MTH00196 232 NLIIEFsgLSRRLPILAITLALTFLSIAGIPPLVGFLGKWLILLSGVVYQYYLIFLLAVFCSVIAGVYYVRIV 304
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
9-297 1.51e-15

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 77.30  E-value: 1.51e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869    9 IMLTIFMGTMLTMISSHWLLMWVGLEINMLAI-IPILMKKISPRSTEAATKYFLTQATASMLLMFSIVINTANSGQWGIT 87
Cdd:TIGR01770 107 LLLFALLGIFLLVSSNDLLSIYLGLELQSLCFyVLAGLKRKSRFSTEAGLKYFILGAFSSGLLLFGISLIYGFTGSLNFE 186
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869   88 NMHNQLTS------------LVTMAALMMKLGMTPFHFWVPEVTQGISLMSGMLLLTWQKLAPISILLQIFPSM------ 149
Cdd:TIGR01770 187 DLLLFLSNgmlnisllllgiVLILVGLLFKLSAVPFHMWVPDVYEGAPTPVTAFFSIVPKIAIFAVFLRLFLYIlfgfse 266
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869  150 -NPNIILLIAILSILVGGWGGLNQTQLRKILAYSSIAHMGWMMAILMyCPSLTMLNLLIYLMLTITLFSVLNINTNTTTL 228
Cdd:TIGR01770 267 aWQIFLAIIAFLSMLIGNFGALAQKKVKRLLAYSSISHVGYILIGLL-AGTLEGIKAVLFYIFIYALMSLGAFGVLSLLR 345
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869  229 TLSNTWNKT-----------PMITLTILISLLSLGGLPPLTGFLPKWTIIQELTKNSNIMLATIMAIMALLNLYFYMRLI 297
Cdd:TIGR01770 346 SYKDEWIEYisdfaglfktnPILAILILIFMFSLAGIPPLAGFFGKFYVFFALLKSGLYWLAVIAVLTSVIGAFYYLRVV 425
PRK05777 PRK05777
NADH-quinone oxidoreductase subunit NuoN;
8-218 7.10e-15

NADH-quinone oxidoreductase subunit NuoN;


Pssm-ID: 235603 [Multi-domain]  Cd Length: 476  Bit Score: 75.24  E-value: 7.10e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869   8 FIMLTIFM-GTMLTMISS-HWLLMWVGLEINMLAI-IPILMKKISPRSTEAATKYFLTQATASMLLMFSIVINTANSGQW 84
Cdd:PRK05777 105 FYLLVLFAlLGMMVMVSAnDLLTLFLGLELLSLPLyALAALRRDRRRSLEAAIKYFVLGALASGFLLYGMSLLYGATGSL 184
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869  85 GITNMHNQLTSLVT------------MAALMMKLGMTPFHFWVPEVTQGISLMSGMLLLTWQKLAPISILLQI----FPS 148
Cdd:PRK05777 185 SFAGIAKALADGSGnsllllfglvflLVGLAFKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAVLLRLlvvaFGG 264
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 671759869 149 MNP---NIILLIAILSILVGGWGGLNQTQLRKILAYSSIAHMGWMMAILMYCPSL----TMLNLLIYLMLTITLFSV 218
Cdd:PRK05777 265 LSEdwqQVLAIIAIASMLVGNLAALSQTNIKRLLAYSSIAHAGYLLVGLAAGTAEgysaVLFYLLAYLFMTLGAFGV 341
NADH_dehy_S2_C pfam06444
NADH dehydrogenase subunit 2 C-terminus; This family consists of the C-terminal region ...
291-341 2.98e-10

NADH dehydrogenase subunit 2 C-terminus; This family consists of the C-terminal region specific to the eukaryotic NADH dehydrogenase subunit 2 protein and is found in conjunction with pfam00361.


Pssm-ID: 461914 [Multi-domain]  Cd Length: 51  Bit Score: 54.96  E-value: 2.98e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 671759869  291 YFYMRLIYSTSLTMFPTLNNMKMKWQFQQTKQIFLLSPLVILATLTLPLSP 341
Cdd:pfam06444   1 FFYLRLSYSTTLTLFPNTNNSKMKWRFNSTKNTLLLPTLTTLSILLLPLTP 51
ND2 MTH00198
NADH dehydrogenase subunit 2; Provisional
9-191 8.28e-10

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214454 [Multi-domain]  Cd Length: 607  Bit Score: 59.87  E-value: 8.28e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869   9 IMLTIFMGTMLTMISSHWLLMWVGLEINMLAIIPILMKKISPRST---------EAATKYFLTQATASMLLMFSIVIN-- 77
Cdd:MTH00198 193 LVLIVGLGGLLLIESANWLTIYLALEFQTLALFILAGEGSQPGSHfpspgntppESGLKYWILGAMSSGFYLFGCALYfg 272
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869  78 -TANSGQWGI--------TNM---HNQLTSLVTMAALMMKLGMTPFHFWVPEVTQGISLMSGMLLLTWQKLAPISILLQI 145
Cdd:MTH00198 273 fTGNEGMLGTilsatletTNIelrQGSLGYLFITVAILFKLAAAPFHMWTPDVYEGAPTPTTALIAIIPKFTVYILLTSL 352
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 671759869 146 FpsMNPNIILLIAILSILVGGWGGLNQTQLRKILAYSSIAHMGWMM 191
Cdd:MTH00198 353 V--ITSKLLLSVAIISLVVGAFGALNQTRIKRLLAYSGIGHIGFIL 396
HyfB COG0651
Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy ...
8-301 4.13e-09

Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 440416 [Multi-domain]  Cd Length: 430  Bit Score: 57.46  E-value: 4.13e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869   8 FIMLTIFMGTMLTMISSHWLLMWVGLEINMLAIIPILMKKISPRSTEAATKYFLTQATASMLLMFSIVINTANSGQWGIT 87
Cdd:COG0651  111 PLFLLLLAGMNGAFLTGDLFNLFVFFEVMLLASYGLVALGGTKEALRAGLKYLILNLVGSALFLLGVGLLYGATGTLNMA 190
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869  88 NMHNQLTSL----------VTMAALMMKLGMTPFHFWVPEV-----TQGISLMSGMLLltwqKLAPISIL---LQIFPSM 149
Cdd:COG0651  191 DLAARLAELdpglllaafaLLLVGFGIKAALFPLHFWLPDAypaapSPVSALLSGLLT----KVGVYAILrvlTLLFGAD 266
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869 150 NPNIILLIAILS----ILVGGWGGLNQTQLRKILAYSSIAHMGWMMAILMYCPSLTMLNLLIYL----MLTITLF----S 217
Cdd:COG0651  267 PALFLGTLLLVLglltMLVGALGALAQRDLKRLLAYSSVSQIGYILLGLGLGTPLGLAGALFHLlnhaLAKALLFlaagA 346
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869 218 VLNINTNTTTLTLSNTWNKTPMITLTILISLLSLGGLPPLTGFLPKWTIIQELTKNSNIMLATIMAIMALLNLYFYMRLI 297
Cdd:COG0651  347 IERATGTRDLDKLGGLGKRMPLTAAAFLIGALALAGLPPLSGFVSKWLLLQAALEAGAWLLAAVLLLSSLLTLAYFVRIF 426

                 ....
gi 671759869 298 YSTS 301
Cdd:COG0651  427 GRAQ 430
NDH_I_M TIGR01972
proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th ...
4-191 3.97e-05

proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th (based on E. coli) structural gene, M, of bacterial NADH dehydrogenase I, as well as chain 4 of the corresponding mitochondrial complex I and of the chloroplast NAD(P)H dehydrogenase complex. [Energy metabolism, Electron transport]


Pssm-ID: 273903 [Multi-domain]  Cd Length: 481  Bit Score: 45.32  E-value: 3.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869    4 IILMFIMLTIFMGTMLTMISSHWLLMWVGLEINMLAIIPILMKkisPRSTEAATKYFLTQATASMLLMFSIV-INTANSG 82
Cdd:TIGR01972 109 YALLLLLEAGVIGVFLALDLFLFYVFWEAMLIPMYLLIGVWGG---PNRIYAAMKFFLYTLAGSLLMLLAILgLYFLGGG 185
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869   83 QWGITNMHNQLTSLVT--------MAALMMKLGMTPFHFWVPEV-----TQGISLMSGMLLltwqKLAP---ISILLQIF 146
Cdd:TIGR01972 186 TFDLLELLNLPLPFGVqtwlflafFIAFAVKVPLFPLHTWLPDAhveapTAGSVILAGVLL----KMGTygfLRFNLPLF 261
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 671759869  147 P-SMNPNIILLIAILSILV--GGWGGLNQTQLRKILAYSSIAHMGWMM 191
Cdd:TIGR01972 262 PdASLYFAPVLAALGVIAIiyGALIALAQTDIKRLIAYSSISHMGFVL 309
PRK02504 PRK02504
NAD(P)H-quinone oxidoreductase subunit N;
9-297 1.25e-04

NAD(P)H-quinone oxidoreductase subunit N;


Pssm-ID: 235044 [Multi-domain]  Cd Length: 513  Bit Score: 43.50  E-value: 1.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869   9 IMLTIFMGTMLTMISSHWLLMWVGLEinMLAIIPILMK---KISPRSTEAATKYFLTQATASMLLMFSIVINTANSGqwG 85
Cdd:PRK02504 115 ILLTATLGGMFLSGATELVMIFISLE--TLSIASYLLTgymKRDPRSNEAALKYLLIGAASSAIFLYGSSLLYGLSG--G 190
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869  86 ITNMHNQLTSLVT-------------MAALMMKLGMTPFHFWVPEVTQGISLMSGMLLLTWQKLA----PISILLQIFPS 148
Cdd:PRK02504 191 STQLSAIALALITspslglalalvfvIAGIAFKISAVPFHQWTPDVYEGSPTPVVAFLSVGSKAAgfalAIRLLVTAFPS 270
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869 149 MNPN---IILLIAILSILVGGWGGLNQTQLRKILAYSSIAHMGWMMaILMYCP-----SLTMLNLLIYLMLT------IT 214
Cdd:PRK02504 271 FDEQwklLFTALAILSMVLGNVVALAQTSMKRMLAYSSIGQAGFVM-IGLVAGteagyASMVFYLLAYLFMNlgafacVI 349
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869 215 LFSVLNINTNTTTLTLSntWNKTPMITLTILISLLSLGGLPPLTGFLPKWTIIQELTKNSNIMLATIMAIMALLNLYFYM 294
Cdd:PRK02504 350 LFSLRTGTDQISDYAGL--YQKDPLLTLGLSLCLLSLGGIPPLAGFFGKIYLFWAGWQAGLYLLVLVGLVTSVISIYYYI 427

                 ...
gi 671759869 295 RLI 297
Cdd:PRK02504 428 RVI 430
NuoM COG1008
NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH: ...
49-192 2.68e-04

NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 4 (chain M) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440632 [Multi-domain]  Cd Length: 488  Bit Score: 42.76  E-value: 2.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869  49 SPRSTEAATKYFLTQATASMLLMFSIVINTANSGQW--GITNMHNQLTSLVT--------MAALMMKLGMTPFHFWVPEV 118
Cdd:COG1008  156 GERRIYAAIKFFLYTLAGSLLMLVAILALYFLAGALtfDIAELAAAPLPLTAqlllflafFIAFAVKVPMFPFHTWLPDA 235
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869 119 -----TQGISLMSGMLL----------------LTWQKLAPISILLQIFpsmnpniilliailSILVGGWGGLNQTQLRK 177
Cdd:COG1008  236 hveapTAGSVLLAGVLLkmggygllrfalplfpEASAYFAPLLAALGVI--------------GIIYGALVALAQTDLKR 301
                        170
                 ....*....|....*
gi 671759869 178 ILAYSSIAHMGWMMA 192
Cdd:COG1008  302 LIAYSSVSHMGFVLL 316
PRK12650 PRK12650
DUF4040 family protein;
8-192 7.95e-04

DUF4040 family protein;


Pssm-ID: 237158 [Multi-domain]  Cd Length: 962  Bit Score: 41.57  E-value: 7.95e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869   8 FIMLTIFMGTMLTMI-SSHWLLMWVGLEINMLAIIpILMKKISPRSTEAATKYFLTQATASMLLMFSIVINtanSGQWGI 86
Cdd:PRK12650 113 YLLMTAFMAAMLLLVlADDVVVLFVAWELVSLASF-FLIARSGSGGEAGSIRTLILTFFGGLTLLAAVAIA---ATQTGT 188
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869  87 TNMHNQLTS---------------LVTMAALMmKLGMTPFHFWVPEVTQGISLMSGMLLLTWQKLAPISILLQIFPSMNP 151
Cdd:PRK12650 189 TSLSGILHSdvwaekpglttvvavLIAVAAFT-KSAQFPFHFWLPEAMAAITPVSAFLHAAAVVKAGIYLLLRFSPVFHD 267
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 671759869 152 NII-----LLIAILSILVGGWGGLNQTQLRKILAYSSIAHMGWMMA 192
Cdd:PRK12650 268 VAVwnwllIIVGMITALMGAVFAVQKTDLKKLTAYSTVSQLGWIVA 313
PRK08376 PRK08376
putative monovalent cation/H+ antiporter subunit D; Reviewed
30-191 9.06e-04

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 236252 [Multi-domain]  Cd Length: 521  Bit Score: 40.85  E-value: 9.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869  30 WVGLEINMLAIIPILMKKI-SPRSTEAATKYFLTQATASMLLMFSIVINTansGQWGITNM---------HNQLTSLVTM 99
Cdd:PRK08376 147 FVFLEIMSIASYALVAFRNdTWEAIEAGIKYMFVGSLASSMVLLGIALLY---GQYGTLNMaylavkmseNPTVVAKIAL 223
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671759869 100 A----ALMMKLGMTPFHFWVPEV-TQGISLMSGMLLLTWQK--LAPISILLQIF-PSMNPNI----ILLIAILSILVGGW 167
Cdd:PRK08376 224 AlfiaGLAMKSGAVPVHMWLPDAyPAAPSSISAMLLVIKQAglYALARVLFSIYgPAINLATvgwvIIILGCLTMFVGVA 303
                        170       180
                 ....*....|....*....|....
gi 671759869 168 GGLNQTQLRKILAYSSIAHMGWMM 191
Cdd:PRK08376 304 MAVVQKDVKRLLAYHSVSQIGYML 327
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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