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Conserved domains on  [gi|700630246|gb|AIU95339|]
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pds5, partial [Drosophila adunca]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PDS5 super family cl47186
Sister chromatid cohesion protein PDS5; Pds5 plays a crucial role in sister chromatid cohesion. ...
 1-125 5.88e-30

Sister chromatid cohesion protein PDS5; Pds5 plays a crucial role in sister chromatid cohesion. Together with WapI and Scc3, it is involved in the release of the cohesin complex from chromosomes during S phase. The core of the cohesin complex consists of a coiled-coiled heterodimer of Smc1 and Smc30, together with Scc1 (also called kleisin). Pds5 interacts with Scc1 via a conserved patch on the surface of its heat repeats. Pds5 also promotes the acetylation of Smc3 that protects cohesin from releasing activity in G2 phase.


The actual alignment was detected with superfamily member cd19953:

Pssm-ID: 410996 [Multi-domain]  Cd Length: 630  Bit Score: 112.23  E-value: 5.88e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700630246   1 DQHSVKVKNFFLDVLSPLITEADNLSVELLDLILINIVEPNKSTNKHAHELTEQLLVKTGDAFEATIKLFFNQSLVMDKP 80
Cdd:cd19953  135 DDHPKNVENLMLDILVELIDESESVPQEVLDIILAQFLKKNKSENPPAYRLAVEVCERCSDKLQRYVTQFFSEVLVDAST 214

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 700630246  81 NTKLVITS----KIYDIIYELNQINSDLLISVLPQLENKLLSTEDSERL 125
Cdd:cd19953  215 EEDSEEDSeeleKAHELIYELWRIAPELLLSVIPQLEEELKADDVDVRL 263
 
Name Accession Description Interval E-value
PDS5 cd19953
Sister chromatid cohesion protein PDS5; Pds5 plays a crucial role in sister chromatid cohesion. ...
 1-125 5.88e-30

Sister chromatid cohesion protein PDS5; Pds5 plays a crucial role in sister chromatid cohesion. Together with WapI and Scc3, it is involved in the release of the cohesin complex from chromosomes during S phase. The core of the cohesin complex consists of a coiled-coiled heterodimer of Smc1 and Smc30, together with Scc1 (also called kleisin). Pds5 interacts with Scc1 via a conserved patch on the surface of its heat repeats. Pds5 also promotes the acetylation of Smc3 that protects cohesin from releasing activity in G2 phase.


Pssm-ID: 410996 [Multi-domain]  Cd Length: 630  Bit Score: 112.23  E-value: 5.88e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700630246   1 DQHSVKVKNFFLDVLSPLITEADNLSVELLDLILINIVEPNKSTNKHAHELTEQLLVKTGDAFEATIKLFFNQSLVMDKP 80
Cdd:cd19953  135 DDHPKNVENLMLDILVELIDESESVPQEVLDIILAQFLKKNKSENPPAYRLAVEVCERCSDKLQRYVTQFFSEVLVDAST 214

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 700630246  81 NTKLVITS----KIYDIIYELNQINSDLLISVLPQLENKLLSTEDSERL 125
Cdd:cd19953  215 EEDSEEDSeeleKAHELIYELWRIAPELLLSVIPQLEEELKADDVDVRL 263
PDS5 pfam20168
Sister chromatid cohesion protein PDS5 protein; This entry represents the Sister chromatid ...
 1-125 7.93e-26

Sister chromatid cohesion protein PDS5 protein; This entry represents the Sister chromatid cohesion protein PDS5. The large PDS5 molecule is exclusively alpha helical, composed of a large number of HEAT-like repeats and helical extensions/additions that deviate from the HEAT repeat pattern.


Pssm-ID: 466319 [Multi-domain]  Cd Length: 1051  Bit Score: 100.75  E-value: 7.93e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700630246     1 DQHSVKVKNFFLDVLSPLITEADNLSVELLDLILINIVEPNKSTNKHAHELTEQLLVKTGDAFEATIKLFFNQSLvMDKP 80
Cdd:pfam20168  137 RPHSKKVENFMLDILSELIDESDSLPQEVLDLILAQFLRKKKKENPPAFRLAVDVCNACADKLQRYVCQYFSEIL-LEGD 215

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 700630246    81 NTKLVITSKIYDIIYELNQINSDLLISVLPQLENKLLSTEDSERL 125
Cdd:pfam20168  216 ESDLELLKKAHDLILELWRIAPSLLLNVIPQLEEELKADDVDIRL 260
 
Name Accession Description Interval E-value
PDS5 cd19953
Sister chromatid cohesion protein PDS5; Pds5 plays a crucial role in sister chromatid cohesion. ...
 1-125 5.88e-30

Sister chromatid cohesion protein PDS5; Pds5 plays a crucial role in sister chromatid cohesion. Together with WapI and Scc3, it is involved in the release of the cohesin complex from chromosomes during S phase. The core of the cohesin complex consists of a coiled-coiled heterodimer of Smc1 and Smc30, together with Scc1 (also called kleisin). Pds5 interacts with Scc1 via a conserved patch on the surface of its heat repeats. Pds5 also promotes the acetylation of Smc3 that protects cohesin from releasing activity in G2 phase.


Pssm-ID: 410996 [Multi-domain]  Cd Length: 630  Bit Score: 112.23  E-value: 5.88e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700630246   1 DQHSVKVKNFFLDVLSPLITEADNLSVELLDLILINIVEPNKSTNKHAHELTEQLLVKTGDAFEATIKLFFNQSLVMDKP 80
Cdd:cd19953  135 DDHPKNVENLMLDILVELIDESESVPQEVLDIILAQFLKKNKSENPPAYRLAVEVCERCSDKLQRYVTQFFSEVLVDAST 214

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 700630246  81 NTKLVITS----KIYDIIYELNQINSDLLISVLPQLENKLLSTEDSERL 125
Cdd:cd19953  215 EEDSEEDSeeleKAHELIYELWRIAPELLLSVIPQLEEELKADDVDVRL 263
PDS5 pfam20168
Sister chromatid cohesion protein PDS5 protein; This entry represents the Sister chromatid ...
 1-125 7.93e-26

Sister chromatid cohesion protein PDS5 protein; This entry represents the Sister chromatid cohesion protein PDS5. The large PDS5 molecule is exclusively alpha helical, composed of a large number of HEAT-like repeats and helical extensions/additions that deviate from the HEAT repeat pattern.


Pssm-ID: 466319 [Multi-domain]  Cd Length: 1051  Bit Score: 100.75  E-value: 7.93e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700630246     1 DQHSVKVKNFFLDVLSPLITEADNLSVELLDLILINIVEPNKSTNKHAHELTEQLLVKTGDAFEATIKLFFNQSLvMDKP 80
Cdd:pfam20168  137 RPHSKKVENFMLDILSELIDESDSLPQEVLDLILAQFLRKKKKENPPAFRLAVDVCNACADKLQRYVCQYFSEIL-LEGD 215

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 700630246    81 NTKLVITSKIYDIIYELNQINSDLLISVLPQLENKLLSTEDSERL 125
Cdd:pfam20168  216 ESDLELLKKAHDLILELWRIAPSLLLNVIPQLEEELKADDVDIRL 260
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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