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Conserved domains on  [gi|703912286|gb|AIW50704|]
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dwarf 8 protein, partial [Hyparrhenia hirta]

Protein Classification

GRAS family protein( domain architecture ID 10572316)

GRAS family protein such as Arabidopsis thaliana protein SCARECROW, a transcription factor required for quiescent center cells specification and maintenance of surrounding stem cells, and for the asymmetric cell division involved in radial pattern formation in roots

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GRAS super family cl15987
GRAS domain family; Proteins in the GRAS (GAI, RGA, SCR) family are known as major players in ...
 238-358 1.87e-52

GRAS domain family; Proteins in the GRAS (GAI, RGA, SCR) family are known as major players in gibberellin (GA) signaling, which regulates various aspects of plant growth and development. Mutation of the SCARECROW (SCR) gene results in a radial pattern defect, loss of a ground tissue layer, in the root. The PAT1 protein is involved in phytochrome A signal transduction. A sequence, structure and evolutionary analysis showed that the GRAS family emerged in bacteria and belongs to the Rossmann-fold, AdoMET (SAM)-dependent methyltransferase superfamily. All bacterial, and a subset of plant GRAS proteins, are predicted to be active and function as small-molecule methylases. Several plant GRAS proteins lack one or more AdoMet (SAM)-binding residues while preserving their substrate-binding residues. Although GRAS proteins are implicated to function as transcriptional factors, the above analysis suggests that they instead might either modify or bind small molecules.


The actual alignment was detected with superfamily member pfam03514:

Pssm-ID: 397536  Cd Length: 374  Bit Score: 177.86  E-value: 1.87e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703912286  238 LVHALLACAEAVQQENFSAADALVKQIPMLASSQGGAMRKVAAYFGEALARRVYR-----FRPTPDTSLLDAAVADFLHA 312
Cdd:pfam03514   1 LVHLLLACAEAVSSGDLSLAQAILARLNQLASPAGDPMQRLAAYFTEALAARLARsgssiYSALPPRPTSPSDSIERISA 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 703912286  313 H--FYESCPYLKFAHFTANQAILEAFAGCRRVHVIDFGIKQGLQWPAL 358
Cdd:pfam03514  81 YklFYEVSPYLKFGHFTANQAILEAFEGEERVHIIDFDIGQGLQWPSL 128
DELLA pfam12041
Transcriptional regulator DELLA protein N terminal; Gibberellins are plant hormones which have ...
 30-103 1.48e-33

Transcriptional regulator DELLA protein N terminal; Gibberellins are plant hormones which have great impact on growth signalling. DELLA proteins are transcriptional regulators of growth related proteins which are downregulated when gibberellins bind to their receptor GID1. GID1 forms a complex with DELLA proteins and signals them towards 26S proteasome. The N terminal of DELLA proteins contains conserved DELLA and VHYNP motifs which are important for GID1 binding and proteolysis of the DELLA proteins.


:

Pssm-ID: 403308  Cd Length: 68  Bit Score: 118.64  E-value: 1.48e-33
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 703912286   30 DEMLAALGYKVRSSEMADVAQKLEQLEMAMGmggvggagaTADDGFISHLATDTVHYNPSDLSSWVESMLSELN 103
Cdd:pfam12041   1 DELLAVLGYKVRSSDMADVAQKLEQLEMVMG---------NAQEDGISHLASDTVHYNPSDLSSWVESMLSELN 65
 
Name Accession Description Interval E-value
GRAS pfam03514
GRAS domain family; Proteins in the GRAS (GAI, RGA, SCR) family are known as major players in ...
 238-358 1.87e-52

GRAS domain family; Proteins in the GRAS (GAI, RGA, SCR) family are known as major players in gibberellin (GA) signaling, which regulates various aspects of plant growth and development. Mutation of the SCARECROW (SCR) gene results in a radial pattern defect, loss of a ground tissue layer, in the root. The PAT1 protein is involved in phytochrome A signal transduction. A sequence, structure and evolutionary analysis showed that the GRAS family emerged in bacteria and belongs to the Rossmann-fold, AdoMET (SAM)-dependent methyltransferase superfamily. All bacterial, and a subset of plant GRAS proteins, are predicted to be active and function as small-molecule methylases. Several plant GRAS proteins lack one or more AdoMet (SAM)-binding residues while preserving their substrate-binding residues. Although GRAS proteins are implicated to function as transcriptional factors, the above analysis suggests that they instead might either modify or bind small molecules.


Pssm-ID: 397536  Cd Length: 374  Bit Score: 177.86  E-value: 1.87e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703912286  238 LVHALLACAEAVQQENFSAADALVKQIPMLASSQGGAMRKVAAYFGEALARRVYR-----FRPTPDTSLLDAAVADFLHA 312
Cdd:pfam03514   1 LVHLLLACAEAVSSGDLSLAQAILARLNQLASPAGDPMQRLAAYFTEALAARLARsgssiYSALPPRPTSPSDSIERISA 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 703912286  313 H--FYESCPYLKFAHFTANQAILEAFAGCRRVHVIDFGIKQGLQWPAL 358
Cdd:pfam03514  81 YklFYEVSPYLKFGHFTANQAILEAFEGEERVHIIDFDIGQGLQWPSL 128
DELLA pfam12041
Transcriptional regulator DELLA protein N terminal; Gibberellins are plant hormones which have ...
 30-103 1.48e-33

Transcriptional regulator DELLA protein N terminal; Gibberellins are plant hormones which have great impact on growth signalling. DELLA proteins are transcriptional regulators of growth related proteins which are downregulated when gibberellins bind to their receptor GID1. GID1 forms a complex with DELLA proteins and signals them towards 26S proteasome. The N terminal of DELLA proteins contains conserved DELLA and VHYNP motifs which are important for GID1 binding and proteolysis of the DELLA proteins.


Pssm-ID: 403308  Cd Length: 68  Bit Score: 118.64  E-value: 1.48e-33
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 703912286   30 DEMLAALGYKVRSSEMADVAQKLEQLEMAMGmggvggagaTADDGFISHLATDTVHYNPSDLSSWVESMLSELN 103
Cdd:pfam12041   1 DELLAVLGYKVRSSDMADVAQKLEQLEMVMG---------NAQEDGISHLASDTVHYNPSDLSSWVESMLSELN 65
 
Name Accession Description Interval E-value
GRAS pfam03514
GRAS domain family; Proteins in the GRAS (GAI, RGA, SCR) family are known as major players in ...
 238-358 1.87e-52

GRAS domain family; Proteins in the GRAS (GAI, RGA, SCR) family are known as major players in gibberellin (GA) signaling, which regulates various aspects of plant growth and development. Mutation of the SCARECROW (SCR) gene results in a radial pattern defect, loss of a ground tissue layer, in the root. The PAT1 protein is involved in phytochrome A signal transduction. A sequence, structure and evolutionary analysis showed that the GRAS family emerged in bacteria and belongs to the Rossmann-fold, AdoMET (SAM)-dependent methyltransferase superfamily. All bacterial, and a subset of plant GRAS proteins, are predicted to be active and function as small-molecule methylases. Several plant GRAS proteins lack one or more AdoMet (SAM)-binding residues while preserving their substrate-binding residues. Although GRAS proteins are implicated to function as transcriptional factors, the above analysis suggests that they instead might either modify or bind small molecules.


Pssm-ID: 397536  Cd Length: 374  Bit Score: 177.86  E-value: 1.87e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 703912286  238 LVHALLACAEAVQQENFSAADALVKQIPMLASSQGGAMRKVAAYFGEALARRVYR-----FRPTPDTSLLDAAVADFLHA 312
Cdd:pfam03514   1 LVHLLLACAEAVSSGDLSLAQAILARLNQLASPAGDPMQRLAAYFTEALAARLARsgssiYSALPPRPTSPSDSIERISA 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 703912286  313 H--FYESCPYLKFAHFTANQAILEAFAGCRRVHVIDFGIKQGLQWPAL 358
Cdd:pfam03514  81 YklFYEVSPYLKFGHFTANQAILEAFEGEERVHIIDFDIGQGLQWPSL 128
DELLA pfam12041
Transcriptional regulator DELLA protein N terminal; Gibberellins are plant hormones which have ...
 30-103 1.48e-33

Transcriptional regulator DELLA protein N terminal; Gibberellins are plant hormones which have great impact on growth signalling. DELLA proteins are transcriptional regulators of growth related proteins which are downregulated when gibberellins bind to their receptor GID1. GID1 forms a complex with DELLA proteins and signals them towards 26S proteasome. The N terminal of DELLA proteins contains conserved DELLA and VHYNP motifs which are important for GID1 binding and proteolysis of the DELLA proteins.


Pssm-ID: 403308  Cd Length: 68  Bit Score: 118.64  E-value: 1.48e-33
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 703912286   30 DEMLAALGYKVRSSEMADVAQKLEQLEMAMGmggvggagaTADDGFISHLATDTVHYNPSDLSSWVESMLSELN 103
Cdd:pfam12041   1 DELLAVLGYKVRSSDMADVAQKLEQLEMVMG---------NAQEDGISHLASDTVHYNPSDLSSWVESMLSELN 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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