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Conserved domains on  [gi|712042053|gb|AIW64049|]
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NADH dehydrogenase subunit 6 (mitochondrion) [Microcebus rufus]

Protein Classification

NADH dehydrogenase subunit 6( domain architecture ID 10009569)

NADH dehydrogenase subunit 6 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-173 3.25e-80

NADH dehydrogenase subunit 6; Provisional


:

Pssm-ID: 214421  Cd Length: 175  Bit Score: 235.47  E-value: 3.25e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712042053   1 MAYTIFLLSTIFVLGFMSFSSKPSPIYGGVGLIVSGAVGCSMIMGFGVSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712042053  81 TWGSSIVIWGALLLGVFMESLLMVWLLEHDGVEMVIGFSSLEDWIMFMDKGFSVVREDSLGVSALYSYASWFMVAAGWAL 160
Cdd:MTH00109  82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                        170
                 ....*....|...
gi 712042053 161 FISVLIVIEIIRG 173
Cdd:MTH00109 162 FIGVFVIIEITRG 174
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-173 3.25e-80

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 235.47  E-value: 3.25e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712042053   1 MAYTIFLLSTIFVLGFMSFSSKPSPIYGGVGLIVSGAVGCSMIMGFGVSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712042053  81 TWGSSIVIWGALLLGVFMESLLMVWLLEHDGVEMVIGFSSLEDWIMFMDKGFSVVREDSLGVSALYSYASWFMVAAGWAL 160
Cdd:MTH00109  82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                        170
                 ....*....|...
gi 712042053 161 FISVLIVIEIIRG 173
Cdd:MTH00109 162 FIGVFVIIEITRG 174
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
21-170 3.63e-08

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 49.81  E-value: 3.63e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712042053   21 SKPSPIYGGVGLIVSGAVGCSMIMGFGVSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPETWGSSIVIWGALLLGVFMes 100
Cdd:pfam00499   5 TSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGLLL-- 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712042053  101 llmvwllehdGVEMVIGFSSLEDWIMFMDKGFSVVREDSLGVsALYSYASWFMVAAGWALFISVLIVIEI 170
Cdd:pfam00499  83 ----------LALLLLVLLSASLTPAAAAAAPDVGNIEAIGE-LLFTDYLLPFELASVLLLVALVGAIVL 141
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-173 3.25e-80

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 235.47  E-value: 3.25e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712042053   1 MAYTIFLLSTIFVLGFMSFSSKPSPIYGGVGLIVSGAVGCSMIMGFGVSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712042053  81 TWGSSIVIWGALLLGVFMESLLMVWLLEHDGVEMVIGFSSLEDWIMFMDKGFSVVREDSLGVSALYSYASWFMVAAGWAL 160
Cdd:MTH00109  82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                        170
                 ....*....|...
gi 712042053 161 FISVLIVIEIIRG 173
Cdd:MTH00109 162 FIGVFVIIEITRG 174
ND6 MTH00065
NADH dehydrogenase subunit 6; Provisional
 1-173 1.45e-34

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214415  Cd Length: 172  Bit Score: 119.18  E-value: 1.45e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712042053   1 MAYTIFLLSTIFVLGFMSFSSKPSPIYGGVGLIVSGAVGCSMIMGFGVSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00065   1 MMYLGFLGMLGLVVGLVAVASNPSPYFAALGLVLGAVCGCLVLVELGVSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712042053  81 TWGSSIVIWgalLLGVFMESLLMVWLlehdgveMVIGFSSLEDWIMFMDKGFSVVREDSLGVSALYSYASWFMVAAGWAL 160
Cdd:MTH00065  81 AWGSWSVLV---YVLFYLLLLIVGYI-------LFGCNFSLEFLFTNYDTEFSVVGYDWGGVGLMYSSGGWFLMISGWVL 150

                        170
                 ....*....|...
gi 712042053 161 FISVLIVIEIIRG 173
Cdd:MTH00065 151 LLTLFVVLEVTRG 163
ND6 MTH00138
NADH dehydrogenase subunit 6; Provisional
 1-173 1.94e-33

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 177196  Cd Length: 173  Bit Score: 116.39  E-value: 1.94e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712042053   1 MAYTIFLLSTIFVLGFMSFSSKPSPIYGGVGLIVSGAVGCSMIMGFGVSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00138   1 MTYLMSLFLLGLVLGLVAVASNPSPYFAALGLVVVAGVGCGVLVGHGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712042053  81 TWGSSIVIWgaLLLGVFMESLLMVWLLEHDGVEMvigfssleDWIMFMD-KGFSVVREDSLGVSALYSYASWFMVAAGWA 159
Cdd:MTH00138  81 SWGSWSVLG--YVVGYLVGVVLAAGLFWGGWYEG--------SWVVVDElKEFSVLRGDVGGVALMYSSGGGMLVICAWV 150

                        170
                 ....*....|....
gi 712042053 160 LFISVLIVIEIIRG 173
Cdd:MTH00138 151 LLLTLFVVLELTRG 164
ND6 MTH00115
NADH dehydrogenase subunit 6; Provisional
 1-173 1.28e-26

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214424  Cd Length: 174  Bit Score: 99.05  E-value: 1.28e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712042053   1 MAYTIFLLSTIFVLGFMSFSSKPSPIYGGVGLIVSGAVGCSMIMGFGVSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00115   1 MMYFVFLLGVCFVLGVVGVASNPSPYYGVVSLVLASVFGCGVLVSLGGSFVSLVLFLVYLGGMLVVFAYSVSLAADPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712042053  81 TWGSSIVIWGallLGVFMESLLMVWLLEHDGVEMVIGFSSLEDWImfmdkGFSVVREDSLGVSALYSYASWFMVAAGWAL 160
Cdd:MTH00115  81 AWGDWGVVGY---VVGFVLVVVVVGVVVGGLWGMEGVGVVTVDSG-----GLFVVRLDFSGVSLFYSSGGGGLLVCGWGL 152

                        170
                 ....*....|...
gi 712042053 161 FISVLIVIEIIRG 173
Cdd:MTH00115 153 LLTLFVVLELVRG 165
ND6 MTH00214
NADH dehydrogenase subunit 6; Provisional
 1-173 1.87e-15

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214461  Cd Length: 168  Bit Score: 69.63  E-value: 1.87e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712042053   1 MAYTIFLLSTIFVLGFMSFSSKPSPIYGGVGLIVSGAVGCSMIMGFGVSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00214   1 MLYFVFLLMFGFLLGLMMVASSPSPYFGALGLVLLALLGCFLLLSHGNSFLGLILFLIYLGGMLVVFSYSAALAADPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712042053  81 TWGSSIVIWGAL--LLGVFMESLLMVWLLEHDGVEMVIGFSSLEdwimfmdkgfsvvredSLGVSALYSYASWFMVAAGW 158
Cdd:MTH00214  81 SWGGWSVLLFFLfyLLGLGFVGFYFYGGWEMLSWMGVDEANNLD----------------LSGVSDLYSRGFFLLLLGGV 144

                        170
                 ....*....|....*
gi 712042053 159 ALFISVLIVIEIIRG 173
Cdd:MTH00214 145 VLFLVLFVVLELVRG 159
ND6 MTH00045
NADH dehydrogenase subunit 6; Validated
 1-173 5.52e-11

NADH dehydrogenase subunit 6; Validated


Pssm-ID: 177120  Cd Length: 162  Bit Score: 57.61  E-value: 5.52e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712042053   1 MAYTIFLLSTIFVLGFMSFSSkpSPIYGGVGLIVSGAVGCSMIMGFGVSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00045   1 MVFYLFLILMLFGSTLVFYSL--SPYYSALGLVLVSLSGCLLLSLLGLSFLALLLLLIYMGGMLVVFVYSSALSAERYPS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712042053  81 TWGSSIVIWGALLLGVFmesllmvwllehdgvemviGFSSLEDWIMFMDKGFSVVREDSL-GVSALYSYASWFMVAAGWA 159
Cdd:MTH00045  79 VSNLGEVLVLSLLLSLW-------------------VFISFDNFLELSNNNWSLVSLSDLvGSSELYNSGGLYLLLGGFI 139

                        170
                 ....*....|....
gi 712042053 160 LFISVLIVIEIIRG 173
Cdd:MTH00045 140 LLVALVVALVISFG 153
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
21-170 3.63e-08

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 49.81  E-value: 3.63e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712042053   21 SKPSPIYGGVGLIVSGAVGCSMIMGFGVSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPETWGSSIVIWGALLLGVFMes 100
Cdd:pfam00499   5 TSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGLLL-- 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712042053  101 llmvwllehdGVEMVIGFSSLEDWIMFMDKGFSVVREDSLGVsALYSYASWFMVAAGWALFISVLIVIEI 170
Cdd:pfam00499  83 ----------LALLLLVLLSASLTPAAAAAAPDVGNIEAIGE-LLFTDYLLPFELASVLLLVALVGAIVL 141
ND6 MTH00212
NADH dehydrogenase subunit 6; Provisional
 7-78 1.68e-03

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214460  Cd Length: 160  Bit Score: 37.29  E-value: 1.68e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 712042053   7 LLSTIFVLGFMSFSSKPSPIYGGVGLIVSGAVGCSMIMGFGVSFMGLMVFLIYLGGMLVVFGYTTAMATEEY 78
Cdd:MTH00212   5 LLLSLLLLLMLLFPLSAHPLTLGVSLLLSSLLSCLIITMESNSWYGYILFLIYIGGLLVLFGYMVALSPNEH 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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