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Conserved domains on  [gi|712042344|gb|AIW64319|]
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NADH dehydrogenase subunit 4L (mitochondrion) [Cheirogaleus crossleyi]

Protein Classification

NADH-ubiquinone oxidoreductase chain 4L( domain architecture ID 10009568)

NADH-ubiquinone oxidoreductase chain 4L is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) and is believed to belong to the minimal assembly required for catalysis; Complex I functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 6.49e-37

NADH dehydrogenase subunit 4L; Provisional


:

Pssm-ID: 177169  Cd Length: 98  Bit Score: 120.04  E-value: 6.49e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712042344  1 MPSISMNMALAFTTALLGMLMFRSHLMSSLLCLEGMMLSMFISSTLLILNMQYTITFMMPILLLVFAACEAAIGLALLVT 80
Cdd:MTH00107  1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                        90
                ....*....|....*...
gi 712042344 81 VSNTYGLDYIQNLNLLQC 98
Cdd:MTH00107 81 VSNTYGTDYVQNLNLLQC 98
 
Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 6.49e-37

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 120.04  E-value: 6.49e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712042344  1 MPSISMNMALAFTTALLGMLMFRSHLMSSLLCLEGMMLSMFISSTLLILNMQYTITFMMPILLLVFAACEAAIGLALLVT 80
Cdd:MTH00107  1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                        90
                ....*....|....*...
gi 712042344 81 VSNTYGLDYIQNLNLLQC 98
Cdd:MTH00107 81 VSNTYGTDYVQNLNLLQC 98
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
3-98 4.42e-11

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 54.11  E-value: 4.42e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712042344   3 SISMNMALAFTTALLGMLmFRSHLMSSLLCLEGMMLSMFISSTLLILNMQYTITFMMPILLLVFAACEAAIGLALLVTVS 82
Cdd:pfam00420  1 AYLLLSGLLFLIGLYGLL-LRRNLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIY 79

                         90
                 ....*....|....*.
gi 712042344  83 NTYGLDYIQNLNLLQC 98
Cdd:pfam00420 80 RTHGTDDVDSLNLLKG 95
 
Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 6.49e-37

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 120.04  E-value: 6.49e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712042344  1 MPSISMNMALAFTTALLGMLMFRSHLMSSLLCLEGMMLSMFISSTLLILNMQYTITFMMPILLLVFAACEAAIGLALLVT 80
Cdd:MTH00107  1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                        90
                ....*....|....*...
gi 712042344 81 VSNTYGLDYIQNLNLLQC 98
Cdd:MTH00107 81 VSNTYGTDYVQNLNLLQC 98
ND4L MTH00126
NADH dehydrogenase subunit 4L; Provisional
 11-98 3.81e-22

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177185  Cd Length: 98  Bit Score: 82.32  E-value: 3.81e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712042344 11 AFTTALLGMLMFRSHLMSSLLCLEGMMLSMFISSTLLILNMQYTITFMMPILLLVFAACEAAIGLALLVTVSNTYGLDYI 90
Cdd:MTH00126 11 AFILGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWALQLESTSFSAAPMLLLAFSACEASAGLALLVATARTHGTDRL 90


                ....*...
gi 712042344 91 QNLNLLQC 98
Cdd:MTH00126 91 QNLNLLQC 98
ND4L MTH00125
NADH dehydrogenase subunit 4L; Provisional
 1-98 7.63e-21

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177184  Cd Length: 98  Bit Score: 79.12  E-value: 7.63e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712042344  1 MPSISMNMALAFTTALLGMLMFRSHLMSSLLCLEGMMLSMFISSTLLILNMQYTITFMMPILLLVFAACEAAIGLALLVT 80
Cdd:MTH00125  1 MTPTHFSLYTAFMLSLLGLSFHRTHLMSALLCLESMMLSLFIMLSLWPITTQTPSFTPMPIILLTFSACEAGTGLALLVA 80

                        90
                ....*....|....*...
gi 712042344 81 VSNTYGLDYIQNLNLLQC 98
Cdd:MTH00125 81 TTRTHGSDHLKNLNLLQC 98
ND4L MTH00067
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.04e-17

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177139  Cd Length: 98  Bit Score: 71.17  E-value: 1.04e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712042344  1 MPSISMNMALAFTTALLGMLMFRSHLMSSLLCLEGMMLSMFISSTLLILNMQYTITFMMPILLLVFAACEAAIGLALLVT 80
Cdd:MTH00067  1 MSPTYFTFYSAFLLGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWSTQFESLSYFSLPMFMLTFSACEASTGLALMVA 80

                        90
                ....*....|....*...
gi 712042344 81 VSNTYGLDYIQNLNLLQC 98
Cdd:MTH00067 81 TTRTHGTDHLKNLNLLQC 98
ND4L MTH00181
NADH dehydrogenase subunit 4L; Provisional
 6-96 3.19e-12

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214450  Cd Length: 93  Bit Score: 56.88  E-value: 3.19e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712042344  6 MNMALAFTTALLGMLMFRSHLMSSLLCLEGMMLSMFISSTLLILNMQYTITFMMPILLLVFAACEAAIGLALLVTVSNTY 85
Cdd:MTH00181  3 FVFISAFILLLLGLSLYKTHLLSLLLCLEGMMLFLFLLLALFSLLSSSSSMLMFGLILLTFSACEAVLGLSLLVATNRTH 82

                        90
                ....*....|.
gi 712042344 86 GLDYIQNLNLL 96
Cdd:MTH00181 83 GSDHLLKFNLL 93
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
3-98 4.42e-11

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 54.11  E-value: 4.42e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712042344   3 SISMNMALAFTTALLGMLmFRSHLMSSLLCLEGMMLSMFISSTLLILNMQYTITFMMPILLLVFAACEAAIGLALLVTVS 82
Cdd:pfam00420  1 AYLLLSGLLFLIGLYGLL-LRRNLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIY 79

                         90
                 ....*....|....*.
gi 712042344  83 NTYGLDYIQNLNLLQC 98
Cdd:pfam00420 80 RTHGTDDVDSLNLLKG 95
ND4L MTH00043
NADH dehydrogenase subunit 4L; Validated
 1-97 6.46e-10

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 214410  Cd Length: 98  Bit Score: 51.07  E-value: 6.46e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712042344  1 MPSISMNMALAFTTALLGMLMFRSHLMSSLLCLEGMMLSMFISSTLLILNMQYTITFMMPILLLVFAACEAAIGLALLVT 80
Cdd:MTH00043  1 MNIILIIILSSFFLGLLGILINRLHLLSILLCLELLLISLFLNISIWSLNYGNFSNLSFSLLLLTLSACEASIGLSLMVL 80

                        90
                ....*....|....*..
gi 712042344 81 VSNTYGLDYIQNLNLLQ 97
Cdd:MTH00043 81 LSRNHNSDLVASLNLLQ 97
ND4L MTH00188
NADH dehydrogenase subunit 4L; Provisional
 3-98 3.88e-07

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177237  Cd Length: 97  Bit Score: 44.19  E-value: 3.88e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712042344  3 SISMNMALAFTTALLGMLMFRSHLMSSLLCLEGMMLSMFISSTLLILNMQYTitFMMPILLLVFAACEAAIGLALLVTVS 82
Cdd:MTH00188  4 SMILVILLFVVLGLFTFLLNRKHLLMLLLSLEAIMLSLFWFLLVGLSYMEKE--LYLSLVLLTFAACEASVGLALLVSLI 81

                        90
                ....*....|....*.
gi 712042344 83 NTYGLDYIQNLNLLQC 98
Cdd:MTH00188 82 RSHGSDYVSSLNLIKC 97
ND4L MTH00162
NADH dehydrogenase subunit 4L; Provisional
 12-92 4.47e-06

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177218  Cd Length: 89  Bit Score: 40.91  E-value: 4.47e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712042344 12 FTTALLGMLMFRSHLMSSLLCLEGMMLSMFISSTLLILNMQYTITFMMpiLLLVFAACEAAIGLALLVTVSNTYGLDYIQ 91
Cdd:MTH00162 11 FFSGLLVFLSKRKHLLLMLLSLEFMVLSLFFLLFLYLSFFNYELYFLL--FFLTFSVCEGALGLSILVSMIRSHGNDYFS 88


                .
gi 712042344 92 N 92
Cdd:MTH00162 89 S 89
ND4L MTH00149
NADH dehydrogenase subunit 4L; Provisional
 10-98 5.88e-06

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214434  Cd Length: 97  Bit Score: 40.98  E-value: 5.88e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712042344 10 LAFTTALLGMLMFRSHLMSSLLCLEGMMLSMFISstLLILNMQYTITFMMPILLLVFAACEAAIGLALLVTVSNTYGLDY 89
Cdd:MTH00149 11 FGFLMGVFALLFQYKHLLSILLSLEALMLSLLVM--MFSSSGLISFSSYLFLIILTFGACEASLGLSLLVSLIRLHGNDY 88


                ....*....
gi 712042344 90 IQNLNLLQC 98
Cdd:MTH00149 89 VSSLSSLKF 97
ND4L MTH00013
NADH dehydrogenase subunit 4L; Validated
 1-98 7.52e-06

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 133655  Cd Length: 97  Bit Score: 40.89  E-value: 7.52e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712042344  1 MPSISMNMALAFTTALLGMLMFRSHLMSSLLCLEGMMLSMFISSTLLILNMQYTITFMMpILLLVFAACEAAIGLALLVT 80
Cdd:MTH00013  1 MMSPLFILSISPFISMFNLSLQRKHLLMSLLSLEAMILSLALFIPLSLMFANQVNGMLA-IVLLTFGACEASLGLSLLVL 79

                        90
                ....*....|....*...
gi 712042344 81 VSNTYGLDYIQNLNLLQC 98
Cdd:MTH00013 80 MTRSYGNDMLKSLTSNKC 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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