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Conserved domains on  [gi|712042375|gb|AIW64348|]
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NADH dehydrogenase subunit 6 (mitochondrion) [Cheirogaleus sibreei]

Protein Classification

NADH dehydrogenase subunit 6( domain architecture ID 10009569)

NADH dehydrogenase subunit 6 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-173 5.71e-78

NADH dehydrogenase subunit 6; Provisional


:

Pssm-ID: 214421  Cd Length: 175  Bit Score: 229.69  E-value: 5.71e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712042375   1 MAYTVFLLSVILVLGFMSFSSKPSPIYGGVGLIVSGAVGCGIIMGFGGSFVGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712042375  81 TWGSSAVIWGVLLVGFVMELLMIMWMVGYDGVEMVIGLGSLEDWVIFVDKGISIIREDSLGVAGLYGYTSWFMMVAGWSL 160
Cdd:MTH00109  82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                        170
                 ....*....|...
gi 712042375 161 FISVLIVIEIVRG 173
Cdd:MTH00109 162 FIGVFVIIEITRG 174
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-173 5.71e-78

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 229.69  E-value: 5.71e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712042375   1 MAYTVFLLSVILVLGFMSFSSKPSPIYGGVGLIVSGAVGCGIIMGFGGSFVGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712042375  81 TWGSSAVIWGVLLVGFVMELLMIMWMVGYDGVEMVIGLGSLEDWVIFVDKGISIIREDSLGVAGLYGYTSWFMMVAGWSL 160
Cdd:MTH00109  82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                        170
                 ....*....|...
gi 712042375 161 FISVLIVIEIVRG 173
Cdd:MTH00109 162 FIGVFVIIEITRG 174
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
21-170 3.45e-09

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 52.51  E-value: 3.45e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712042375   21 SKPSPIYGGVGLIVSGAVGCGIIMGFGGSFVGLMVFLIYLGGMLVVFGYTTAMATEEYPETWGSSAVIWGVLLVGFVMel 100
Cdd:pfam00499   5 TSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGLLL-- 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712042375  101 lmimwmvgydGVEMVIGLGSLEDWVIFVDKGISIIREDSLGVAgLYGYTSWFMMVAGWSLFISVLIVIEI 170
Cdd:pfam00499  83 ----------LALLLLVLLSASLTPAAAAAAPDVGNIEAIGEL-LFTDYLLPFELASVLLLVALVGAIVL 141
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-173 5.71e-78

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 229.69  E-value: 5.71e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712042375   1 MAYTVFLLSVILVLGFMSFSSKPSPIYGGVGLIVSGAVGCGIIMGFGGSFVGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712042375  81 TWGSSAVIWGVLLVGFVMELLMIMWMVGYDGVEMVIGLGSLEDWVIFVDKGISIIREDSLGVAGLYGYTSWFMMVAGWSL 160
Cdd:MTH00109  82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                        170
                 ....*....|...
gi 712042375 161 FISVLIVIEIVRG 173
Cdd:MTH00109 162 FIGVFVIIEITRG 174
ND6 MTH00138
NADH dehydrogenase subunit 6; Provisional
 1-173 5.26e-35

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 177196  Cd Length: 173  Bit Score: 120.63  E-value: 5.26e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712042375   1 MAYTVFLLSVILVLGFMSFSSKPSPIYGGVGLIVSGAVGCGIIMGFGGSFVGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00138   1 MTYLMSLFLLGLVLGLVAVASNPSPYFAALGLVVVAGVGCGVLVGHGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712042375  81 TWGSSAVIWGVLLVGFVMELLMIMWMVGYDGVemviglgsleDWVIFVD-KGISIIREDSLGVAGLYGYTSWFMMVAGWS 159
Cdd:MTH00138  81 SWGSWSVLGYVVGYLVGVVLAAGLFWGGWYEG----------SWVVVDElKEFSVLRGDVGGVALMYSSGGGMLVICAWV 150

                        170
                 ....*....|....
gi 712042375 160 LFISVLIVIEIVRG 173
Cdd:MTH00138 151 LLLTLFVVLELTRG 164
ND6 MTH00065
NADH dehydrogenase subunit 6; Provisional
 1-173 4.63e-33

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214415  Cd Length: 172  Bit Score: 115.33  E-value: 4.63e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712042375   1 MAYTVFLLSVILVLGFMSFSSKPSPIYGGVGLIVSGAVGCGIIMGFGGSFVGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00065   1 MMYLGFLGMLGLVVGLVAVASNPSPYFAALGLVLGAVCGCLVLVELGVSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712042375  81 TWGSSAVIWGVLLVGFVMELLMIMWMvgydgvemviGLGSLEDWVIFVDKGISIIREDSLGVAGLYGYTSWFMMVAGWSL 160
Cdd:MTH00065  81 AWGSWSVLVYVLFYLLLLIVGYILFG----------CNFSLEFLFTNYDTEFSVVGYDWGGVGLMYSSGGWFLMISGWVL 150

                        170
                 ....*....|...
gi 712042375 161 FISVLIVIEIVRG 173
Cdd:MTH00065 151 LLTLFVVLEVTRG 163
ND6 MTH00115
NADH dehydrogenase subunit 6; Provisional
 1-174 2.30e-28

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214424  Cd Length: 174  Bit Score: 103.29  E-value: 2.30e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712042375   1 MAYTVFLLSVILVLGFMSFSSKPSPIYGGVGLIVSGAVGCGIIMGFGGSFVGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00115   1 MMYFVFLLGVCFVLGVVGVASNPSPYYGVVSLVLASVFGCGVLVSLGGSFVSLVLFLVYLGGMLVVFAYSVSLAADPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712042375  81 TWGSSAVIWGVllVGFVMELLMIMWMVGYDGVEMVIGLGSLEDWvifvdkGISIIREDSLGVAGLYGYTSWFMMVAGWSL 160
Cdd:MTH00115  81 AWGDWGVVGYV--VGFVLVVVVVGVVVGGLWGMEGVGVVTVDSG------GLFVVRLDFSGVSLFYSSGGGGLLVCGWGL 152

                        170
                 ....*....|....
gi 712042375 161 FISVLIVIEIVRGW 174
Cdd:MTH00115 153 LLTLFVVLELVRGL 166
ND6 MTH00214
NADH dehydrogenase subunit 6; Provisional
 1-173 2.42e-16

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214461  Cd Length: 168  Bit Score: 72.33  E-value: 2.42e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712042375   1 MAYTVFLLSVILVLGFMSFSSKPSPIYGGVGLIVSGAVGCGIIMGFGGSFVGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00214   1 MLYFVFLLMFGFLLGLMMVASSPSPYFGALGLVLLALLGCFLLLSHGNSFLGLILFLIYLGGMLVVFSYSAALAADPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712042375  81 TWGSSAVIWGVLLVGFVMELLMIMWMVGYDGVEMVIGLGsledwvifvdkgisIIREDSLGVAGLYGYTSWFMMVAGWSL 160
Cdd:MTH00214  81 SWGGWSVLLFFLFYLLGLGFVGFYFYGGWEMLSWMGVDE--------------ANNLDLSGVSDLYSRGFFLLLLGGVVL 146

                        170
                 ....*....|...
gi 712042375 161 FISVLIVIEIVRG 173
Cdd:MTH00214 147 FLVLFVVLELVRG 159
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
21-170 3.45e-09

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 52.51  E-value: 3.45e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712042375   21 SKPSPIYGGVGLIVSGAVGCGIIMGFGGSFVGLMVFLIYLGGMLVVFGYTTAMATEEYPETWGSSAVIWGVLLVGFVMel 100
Cdd:pfam00499   5 TSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGLLL-- 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712042375  101 lmimwmvgydGVEMVIGLGSLEDWVIFVDKGISIIREDSLGVAgLYGYTSWFMMVAGWSLFISVLIVIEI 170
Cdd:pfam00499  83 ----------LALLLLVLLSASLTPAAAAAAPDVGNIEAIGEL-LFTDYLLPFELASVLLLVALVGAIVL 141
ND6 MTH00045
NADH dehydrogenase subunit 6; Validated
 1-173 5.25e-09

NADH dehydrogenase subunit 6; Validated


Pssm-ID: 177120  Cd Length: 162  Bit Score: 52.60  E-value: 5.25e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712042375   1 MAYTVFLLSVILVLGFMSFSSkpSPIYGGVGLIVSGAVGCGIIMGFGGSFVGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00045   1 MVFYLFLILMLFGSTLVFYSL--SPYYSALGLVLVSLSGCLLLSLLGLSFLALLLLLIYMGGMLVVFVYSSALSAERYPS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 712042375  81 TWGSSAViwgvllvgFVMELLMIMWmvgydgvemviGLGSLEDWVIFVDKGISIIREDSL-GVAGLYGYTSWFMMVAGWS 159
Cdd:MTH00045  79 VSNLGEV--------LVLSLLLSLW-----------VFISFDNFLELSNNNWSLVSLSDLvGSSELYNSGGLYLLLGGFI 139

                        170
                 ....*....|....
gi 712042375 160 LFISVLIVIEIVRG 173
Cdd:MTH00045 140 LLVALVVALVISFG 153
ND6 MTH00212
NADH dehydrogenase subunit 6; Provisional
 7-78 9.11e-04

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214460  Cd Length: 160  Bit Score: 38.06  E-value: 9.11e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 712042375   7 LLSVILVLGFMsFSSKPSPIYGGVGLIVSGAVGCGIIMGFGGSFVGLMVFLIYLGGMLVVFGYTTAMATEEY 78
Cdd:MTH00212   6 LLSLLLLLMLL-FPLSAHPLTLGVSLLLSSLLSCLIITMESNSWYGYILFLIYIGGLLVLFGYMVALSPNEH 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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