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Conserved domains on  [gi|749392963|gb|AJF17495|]
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fem1c, partial [Xenopus laevis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR super family cl34000
Ankyrin repeat [Signal transduction mechanisms];
89-158 1.57e-10

Ankyrin repeat [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG0666:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 57.66  E-value: 1.57e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749392963  89 KGKNNFSPLHLAVDKNttcvgrypvckfpSFQVTAILLECGADVNVRDAEQNSPLHVAALNNHPDIMNLL 158
Cdd:COG0666  116 RDKDGETPLHLAAYNG-------------NLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLL 172
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
89-158 1.57e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 57.66  E-value: 1.57e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749392963  89 KGKNNFSPLHLAVDKNttcvgrypvckfpSFQVTAILLECGADVNVRDAEQNSPLHVAALNNHPDIMNLL 158
Cdd:COG0666  116 RDKDGETPLHLAAYNG-------------NLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLL 172
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 89-158 1.21e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 46.97  E-value: 1.21e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749392963  89 KGKNNFSPLHLAVDKNTTCVGRYpvckfpsfqvtaiLLECGADVNVRDAEQNSPLHVAALNNHPDIMNLL 158
Cdd:PHA03100 188 KDVYGFTPLHYAVYNNNPEFVKY-------------LLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLL 244
Ank_2 pfam12796
Ankyrin repeats (3 copies);
97-158 9.84e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 42.03  E-value: 9.84e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 749392963   97 LHLAVDKnttcvGRYPVCKFpsfqvtaiLLECGADVNVRDAEQNSPLHVAALNNHPDIMNLL 158
Cdd:pfam12796   1 LHLAAKN-----GNLELVKL--------LLENGADANLQDKNGRTALHLAAKNGHLEIVKLL 49
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
89-158 1.57e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 57.66  E-value: 1.57e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749392963  89 KGKNNFSPLHLAVDKNttcvgrypvckfpSFQVTAILLECGADVNVRDAEQNSPLHVAALNNHPDIMNLL 158
Cdd:COG0666  116 RDKDGETPLHLAAYNG-------------NLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLL 172
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
89-158 3.37e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 56.89  E-value: 3.37e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749392963  89 KGKNNFSPLHLAVDKNttcvgrypvckfpSFQVTAILLECGADVNVRDAEQNSPLHVAALNNHPDIMNLL 158
Cdd:COG0666  149 QDNDGNTPLHLAAANG-------------NLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLL 205
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
76-158 1.23e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 52.26  E-value: 1.23e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749392963  76 KKQNIYRFLKLHPKGKNNFSPLHLAVDKNTTcvgrypvckfpsfQVTAILLECGADVNVRDAEQNSPLHVAALNNHPDIM 155
Cdd:COG0666   70 ALLLLAAGADINAKDDGGNTLLHAAARNGDL-------------EIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIV 136


                 ...
gi 749392963 156 NLL 158
Cdd:COG0666  137 KLL 139
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
89-158 7.58e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 50.34  E-value: 7.58e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749392963  89 KGKNNFSPLHLAVDKnttcvGRYPVCKFpsfqvtaiLLECGADVNVRDAEQNSPLHVAALNNHPDIMNLL 158
Cdd:COG0666  182 RDNDGETPLHLAAEN-----GHLEIVKL--------LLEAGADVNAKDNDGKTALDLAAENGNLEIVKLL 238
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 89-158 1.21e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 46.97  E-value: 1.21e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749392963  89 KGKNNFSPLHLAVDKNTTCVGRYpvckfpsfqvtaiLLECGADVNVRDAEQNSPLHVAALNNHPDIMNLL 158
Cdd:PHA03100 188 KDVYGFTPLHYAVYNNNPEFVKY-------------LLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLL 244
Ank_2 pfam12796
Ankyrin repeats (3 copies);
97-158 9.84e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 42.03  E-value: 9.84e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 749392963   97 LHLAVDKnttcvGRYPVCKFpsfqvtaiLLECGADVNVRDAEQNSPLHVAALNNHPDIMNLL 158
Cdd:pfam12796   1 LHLAAKN-----GNLELVKL--------LLENGADANLQDKNGRTALHLAAKNGHLEIVKLL 49
Ank_4 pfam13637
Ankyrin repeats (many copies);
114-158 1.41e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 40.34  E-value: 1.41e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 749392963  114 CKFPSFQVTAILLECGADVNVRDAEQNSPLHVAALNNHPDIMNLL 158
Cdd:pfam13637   9 AASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 95-158 6.97e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 41.81  E-value: 6.97e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 749392963  95 SPLHLAvdknttcvgrypvCKFPSFQVTAILLECGADVNVRDAEQNSPLHVAALNNHPDIMNLL 158
Cdd:PTZ00322 117 TPLHIA-------------CANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL 167
Ank_2 pfam12796
Ankyrin repeats (3 copies);
91-158 4.76e-04

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 37.40  E-value: 4.76e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 749392963   91 KNNFSPLHLAvdknttcvgrypvCKFPSFQVTAILLECgADVNVRDaEQNSPLHVAALNNHPDIMNLL 158
Cdd:pfam12796  28 KNGRTALHLA-------------AKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVKLL 80
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 124-158 4.98e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 39.50  E-value: 4.98e-04
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 749392963 124 ILLECGADVNVRDAEQNSPLHVAALNNHPDIMNLL 158
Cdd:PTZ00322 100 ILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVL 134
PHA03095 PHA03095
ankyrin-like protein; Provisional
 94-158 7.30e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 38.85  E-value: 7.30e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 749392963  94 FSPLHLAVDKNTTcvgrYPVCKFpsfqvtaiLLECGADVNVRDAEQNSPLHV--AALNNHPDIMNLL 158
Cdd:PHA03095  84 FTPLHLYLYNATT----LDVIKL--------LIKAGADVNAKDKVGRTPLHVylSGFNINPKVIRLL 138
Ank_5 pfam13857
Ankyrin repeats (many copies);
125-158 9.87e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 35.40  E-value: 9.87e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 749392963  125 LLECG-ADVNVRDAEQNSPLHVAALNNHPDIMNLL 158
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVL 35
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 97-158 1.34e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 38.02  E-value: 1.34e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 749392963  97 LHLAVDKNttcvgrypvckfpSFQVTAILLECGADVNVRDAEQNSPLHVAALNNHPDIMNLL 158
Cdd:PHA02874 128 LHYAIKKG-------------DLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLL 176
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 79-158 1.99e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 37.34  E-value: 1.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749392963  79 NIYRFLKLH-----PKGKNNFSPLHLAVDKNTTCVgryPVCKF---PSFQVTAI-----LLECGADVNVRDAEQNSPLHV 145
Cdd:PHA03100 122 SIVEYLLDNganvnIKNSDGENLLHLYLESNKIDL---KILKLlidKGVDINAKnrvnyLLSYGVPINIKDVYGFTPLHY 198

                         90
                 ....*....|...
gi 749392963 146 AALNNHPDIMNLL 158
Cdd:PHA03100 199 AVYNNNPEFVKYL 211
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 92-136 3.23e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 33.80  E-value: 3.23e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 749392963   92 NNFSPLHLAVDKNttcvGRYPVCKFpsfqvtaiLLECGADVNVRD 136
Cdd:pfam00023   1 DGNTPLHLAAGRR----GNLEIVKL--------LLSKGADVNARD 33
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 125-158 3.95e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 36.58  E-value: 3.95e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 749392963 125 LLECGADVNVRDAEQNSPLHVAALNNHPDIMNLL 158
Cdd:PHA02876 361 LLELGANVNARDYCDKTPIHYAAVRNNVVIINTL 394
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 91-158 5.83e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 36.18  E-value: 5.83e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 749392963  91 KNNFSPLHLAVDK--NTTCVGRypvckfpsfqVTAILLECGADVNVRDAEQNSPLHVAALN--NHPDIMNLL 158
Cdd:PHA03100  66 KNNSTPLHYLSNIkyNLTDVKE----------IVKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYL 127
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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