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Conserved domains on  [gi|751250153|gb|AJF44132|]
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microtubule-associated protein tau 464 [Xenopus laevis]

Protein Classification

PHA03247 and Tubulin-binding domain-containing protein( domain architecture ID 10450448)

PHA03247 and Tubulin-binding domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 299-328 9.35e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 62.04  E-value: 9.35e-13
                          10        20        30
                  ....*....|....*....|....*....|
gi 751250153  299 VQIVHKKVDLGNVQSKCGSKDNLKHVPGGG 328
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 330-359 6.22e-09

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 51.26  E-value: 6.22e-09
                          10        20        30
                  ....*....|....*....|....*....|
gi 751250153  330 IQITHKPIDLTRVTSKCGSFVNIHHKPGGG 359
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 361-390 1.39e-08

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 50.10  E-value: 1.39e-08
                          10        20        30
                  ....*....|....*....|....*....|
gi 751250153  361 VELKSEKLEFDKIQSKIGSLDNVTHVPGGG 390
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 276-297 3.02e-07

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 46.25  E-value: 3.02e-07
                          10        20
                  ....*....|....*....|..
gi 751250153  276 DLKNVRSKIGSTDNIRHQPGGG 297
Cdd:pfam00418   9 DFSKVQSKCGSKDNIKHKPGGG 30
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
 146-295 8.89e-05

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 45.16  E-value: 8.89e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751250153  146 QLGITTRLHRAKEDGGPESATAkLTASRNTPTASRIPAKTSSIPKTPPSTVRRdqrkPPSSMGKPDRESKSGE-RSGYSS 224
Cdd:PHA03307  261 APITLPTRIWEASGWNGPSSRP-GPASSSSSPRERSPSPSPSSPGSGPAPSSP----RASSSSSSSRESSSSStSSSSES 335

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 751250153  225 PGSPGTPTGRSSSQTPTNREPKKIAVIRTPPKSPASAKSRLQPVTSPAAmPDLKNVRSKIGSTDNIRHQPG 295
Cdd:PHA03307  336 SRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGR-PTRRRARAAVAGRARRRDATG 405
 
Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 299-328 9.35e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 62.04  E-value: 9.35e-13
                          10        20        30
                  ....*....|....*....|....*....|
gi 751250153  299 VQIVHKKVDLGNVQSKCGSKDNLKHVPGGG 328
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 330-359 6.22e-09

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 51.26  E-value: 6.22e-09
                          10        20        30
                  ....*....|....*....|....*....|
gi 751250153  330 IQITHKPIDLTRVTSKCGSFVNIHHKPGGG 359
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 361-390 1.39e-08

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 50.10  E-value: 1.39e-08
                          10        20        30
                  ....*....|....*....|....*....|
gi 751250153  361 VELKSEKLEFDKIQSKIGSLDNVTHVPGGG 390
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 276-297 3.02e-07

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 46.25  E-value: 3.02e-07
                          10        20
                  ....*....|....*....|..
gi 751250153  276 DLKNVRSKIGSTDNIRHQPGGG 297
Cdd:pfam00418   9 DFSKVQSKCGSKDNIKHKPGGG 30
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 146-295 8.89e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 45.16  E-value: 8.89e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751250153  146 QLGITTRLHRAKEDGGPESATAkLTASRNTPTASRIPAKTSSIPKTPPSTVRRdqrkPPSSMGKPDRESKSGE-RSGYSS 224
Cdd:PHA03307  261 APITLPTRIWEASGWNGPSSRP-GPASSSSSPRERSPSPSPSSPGSGPAPSSP----RASSSSSSSRESSSSStSSSSES 335

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 751250153  225 PGSPGTPTGRSSSQTPTNREPKKIAVIRTPPKSPASAKSRLQPVTSPAAmPDLKNVRSKIGSTDNIRHQPG 295
Cdd:PHA03307  336 SRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGR-PTRRRARAAVAGRARRRDATG 405
 
Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 299-328 9.35e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 62.04  E-value: 9.35e-13
                          10        20        30
                  ....*....|....*....|....*....|
gi 751250153  299 VQIVHKKVDLGNVQSKCGSKDNLKHVPGGG 328
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 330-359 6.22e-09

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 51.26  E-value: 6.22e-09
                          10        20        30
                  ....*....|....*....|....*....|
gi 751250153  330 IQITHKPIDLTRVTSKCGSFVNIHHKPGGG 359
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 361-390 1.39e-08

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 50.10  E-value: 1.39e-08
                          10        20        30
                  ....*....|....*....|....*....|
gi 751250153  361 VELKSEKLEFDKIQSKIGSLDNVTHVPGGG 390
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 276-297 3.02e-07

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 46.25  E-value: 3.02e-07
                          10        20
                  ....*....|....*....|..
gi 751250153  276 DLKNVRSKIGSTDNIRHQPGGG 297
Cdd:pfam00418   9 DFSKVQSKCGSKDNIKHKPGGG 30
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 146-295 8.89e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 45.16  E-value: 8.89e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751250153  146 QLGITTRLHRAKEDGGPESATAkLTASRNTPTASRIPAKTSSIPKTPPSTVRRdqrkPPSSMGKPDRESKSGE-RSGYSS 224
Cdd:PHA03307  261 APITLPTRIWEASGWNGPSSRP-GPASSSSSPRERSPSPSPSSPGSGPAPSSP----RASSSSSSSRESSSSStSSSSES 335

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 751250153  225 PGSPGTPTGRSSSQTPTNREPKKIAVIRTPPKSPASAKSRLQPVTSPAAmPDLKNVRSKIGSTDNIRHQPG 295
Cdd:PHA03307  336 SRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGR-PTRRRARAAVAGRARRRDATG 405
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
161-276 2.96e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 40.24  E-value: 2.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751250153 161 GPESATAKLTASRNTPTASRIPAKTSSIPKTPPSTVRRDQRKPPSSMgKPDRESKSGERSGYSSPGSPGTPTGRSSSQTP 240
Cdd:PRK12323 380 APVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARR-SPAPEALAAARQASARGPGGAPAPAPAPAAAP 458

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 751250153 241 TNREPKKIAVIRTPPKSPASAKSRLQPVTSPAAMPD 276
Cdd:PRK12323 459 AAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADD 494
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 89-258 4.53e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 39.67  E-value: 4.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751250153  89 SQEKGAQI----STKH-PPAKHPSRLHTVPHKSPSSSTLKSPSSPAASSVRSSQRTSLGTVGQLGITTRLHRAKEDggPE 163
Cdd:PTZ00449 492 SKKKLAPIeeedSDKHdEPPEGPEASGLPPKAPGDKEGEEGEHEDSKESDEPKEGGKPGETKEGEVGKKPGPAKEH--KP 569

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751250153 164 SATAKLTASRNTPTASRIP-----AKTSSIPKTPPSTVRRDQRKPPSSMGKPdresKSGER-SGYSSPGSPGTPTGRSSS 237
Cdd:PTZ00449 570 SKIPTLSKKPEFPKDPKHPkdpeePKKPKRPRSAQRPTRPKSPKLPELLDIP----KSPKRpESPKSPKRPPPPQRPSSP 645

                        170       180
                 ....*....|....*....|.
gi 751250153 238 QTPtnrEPKKIAVIRTPPKSP 258
Cdd:PTZ00449 646 ERP---EGPKIIKSPKPPKSP 663
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 156-269 7.14e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 38.90  E-value: 7.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751250153 156 AKEDGGPESATAKLTASRNTPTASRIPAKTSSIPKTPPSTVRRDQRKPPSSMGKPDResksgersgyssPGSPGTPTGRS 235
Cdd:PTZ00449 543 PKEGGKPGETKEGEVGKKPGPAKEHKPSKIPTLSKKPEFPKDPKHPKDPEEPKKPKR------------PRSAQRPTRPK 610

                         90       100       110
                 ....*....|....*....|....*....|....
gi 751250153 236 SSQTPTNREPKKIAVIRTPPKSPASAKSRLQPVT 269
Cdd:PTZ00449 611 SPKLPELLDIPKSPKRPESPKSPKRPPPPQRPSS 644
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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