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Conserved domains on  [gi|760030155|gb|AJO96517|]
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Sen34p [Saccharomyces cerevisiae YJM1383]

Protein Classification

endA family protein( domain architecture ID 11489069)

endA family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
endA TIGR00324
tRNA-intron lyase; The enzyme catalyses the endonucleolytic cleavage of pre tRNA at the 5' and ...
 94-272 2.96e-67

tRNA-intron lyase; The enzyme catalyses the endonucleolytic cleavage of pre tRNA at the 5' and 3' splice sites to release the intron and produces two half tRNA molecules bearing 5' hydroxyl and 2', 3'-cyclic phosphate termini. The genes are homologous in Eucarya and Archea. The two yeast genes have been functionally studied and are two subunits of a heterotetramer enzyme in yeast the other two subunits of which have no known homologs. [Transcription, RNA processing]


:

Pssm-ID: 129424  Cd Length: 170  Bit Score: 206.55  E-value: 2.96e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 760030155   94 EYQRKFKKDEHIAKLKKIGRinDKTTAEELQRLDKSSNNDQLIESSLFIDIAntsmILRDIRSDSDSLSRDDISDLLFKq 173
Cdd:TIGR00324   1 EIQGKLKGDEVIVKKKTIIS--DLTTREEYGNLDGDSLNLSLIESLYLIDLG----KLRLIRSDSEPLSREELSDLARK- 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 760030155  174 yRQAGKMQTYFLYKALRDQGYVLSPGGRFGGKFIAYPGDPLRFHSHLTIQDAIDYHNEPIDLISMISGARLGTTVKKLWV 253
Cdd:TIGR00324  74 -VERGFMRKYLVYKDLRDRGYVVKTGFKFGADFRLYERGPLRDHSHSEYLVAIDDHDESIDLIDLSSGVRVAHGVKKKLV 152

                         170
                  ....*....|....*....
gi 760030155  254 IGGVAEEtKETHFFSIEWA 272
Cdd:TIGR00324 153 IAYVDEE-KEIHYLSIEWV 170
 
Name Accession Description Interval E-value
endA TIGR00324
tRNA-intron lyase; The enzyme catalyses the endonucleolytic cleavage of pre tRNA at the 5' and ...
 94-272 2.96e-67

tRNA-intron lyase; The enzyme catalyses the endonucleolytic cleavage of pre tRNA at the 5' and 3' splice sites to release the intron and produces two half tRNA molecules bearing 5' hydroxyl and 2', 3'-cyclic phosphate termini. The genes are homologous in Eucarya and Archea. The two yeast genes have been functionally studied and are two subunits of a heterotetramer enzyme in yeast the other two subunits of which have no known homologs. [Transcription, RNA processing]


Pssm-ID: 129424  Cd Length: 170  Bit Score: 206.55  E-value: 2.96e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 760030155   94 EYQRKFKKDEHIAKLKKIGRinDKTTAEELQRLDKSSNNDQLIESSLFIDIAntsmILRDIRSDSDSLSRDDISDLLFKq 173
Cdd:TIGR00324   1 EIQGKLKGDEVIVKKKTIIS--DLTTREEYGNLDGDSLNLSLIESLYLIDLG----KLRLIRSDSEPLSREELSDLARK- 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 760030155  174 yRQAGKMQTYFLYKALRDQGYVLSPGGRFGGKFIAYPGDPLRFHSHLTIQDAIDYHNEPIDLISMISGARLGTTVKKLWV 253
Cdd:TIGR00324  74 -VERGFMRKYLVYKDLRDRGYVVKTGFKFGADFRLYERGPLRDHSHSEYLVAIDDHDESIDLIDLSSGVRVAHGVKKKLV 152

                         170
                  ....*....|....*....
gi 760030155  254 IGGVAEEtKETHFFSIEWA 272
Cdd:TIGR00324 153 IAYVDEE-KEIHYLSIEWV 170
tRNA-intron_lyase_C cd22363
catalytic C-terminal domain of the tRNA-intron lyase; This C-terminal catalytic domain of tRNA ...
 183-271 5.64e-20

catalytic C-terminal domain of the tRNA-intron lyase; This C-terminal catalytic domain of tRNA intron endonucleases cleaves pre tRNA at the 5' and 3' splice sites to release the intron (EC:3.1.27.9). It belongs to a superfamily of nucleases including very short patch repair (Vsr) endonucleases, archaeal Holliday junction resolvases, MutH methyl-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and FokI.


Pssm-ID: 411767  Cd Length: 91  Bit Score: 82.15  E-value: 5.64e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 760030155 183 YFLYKALRDQGYVLSPGGRFGGKFIAYPGDPLRFHSHLTIQdaIDYHNEPIDLISMISGARLGTTVKKLWVIGGVaEETK 262
Cdd:cd22363    6 YLVYKDLRSRGYVVKSGFKFGADFLVYPRGPGLYHAKYLVH--VVPEDEELSWLELVRAGRLAHSVKKTLVLAVV-DEEG 82


                 ....*....
gi 760030155 263 ETHFFSIEW 271
Cdd:cd22363   83 EVTYYSIEW 91
tRNA_int_endo pfam01974
tRNA intron endonuclease, catalytic C-terminal domain; Members of this family cleave pre tRNA ...
 183-260 6.15e-15

tRNA intron endonuclease, catalytic C-terminal domain; Members of this family cleave pre tRNA at the 5' and 3' splice sites to release the intron EC:3.1.27.9.


Pssm-ID: 396521  Cd Length: 85  Bit Score: 68.44  E-value: 6.15e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 760030155  183 YFLYKALRDQGYVLSPGGRFGGKFIAYPGDPLRFHSHLTIQdAIDYhNEPIDLISMISGARLGTTVKKLWVIGGVAEE 260
Cdd:pfam01974   5 YLVYRDLRERGYVVKPGIKFGADFRVYGGGPGKGHSEYLVR-VLSE-DDPISLLDLLRAVRLAHSVRKELVLAIVDDE 80
SEN2 COG1676
tRNA splicing endonuclease subunit SEN34 [Translation, ribosomal structure and biogenesis]; ...
 183-271 1.65e-06

tRNA splicing endonuclease subunit SEN34 [Translation, ribosomal structure and biogenesis]; tRNA splicing endonuclease subunit SEN34 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441282  Cd Length: 173  Bit Score: 47.12  E-value: 1.65e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 760030155 183 YFLYKALRDQGYVLSPGGRFGGKFIAYPGDPLRF-HSHLTIQdAIDYhNEPIDLISMISGARLGTTVKKLWVIgGVAEET 261
Cdd:COG1676   84 YLVYRDLRDRGYVVKTGFKFGSDFRVYERGPGIEdHSPYLVH-VVPE-GTEFSPRELSRAVRLAHSVRKRMVF-AVVDDE 160

                         90
                 ....*....|
gi 760030155 262 KETHFFSIEW 271
Cdd:COG1676  161 GEIEYYKFEW 170
 
Name Accession Description Interval E-value
endA TIGR00324
tRNA-intron lyase; The enzyme catalyses the endonucleolytic cleavage of pre tRNA at the 5' and ...
 94-272 2.96e-67

tRNA-intron lyase; The enzyme catalyses the endonucleolytic cleavage of pre tRNA at the 5' and 3' splice sites to release the intron and produces two half tRNA molecules bearing 5' hydroxyl and 2', 3'-cyclic phosphate termini. The genes are homologous in Eucarya and Archea. The two yeast genes have been functionally studied and are two subunits of a heterotetramer enzyme in yeast the other two subunits of which have no known homologs. [Transcription, RNA processing]


Pssm-ID: 129424  Cd Length: 170  Bit Score: 206.55  E-value: 2.96e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 760030155   94 EYQRKFKKDEHIAKLKKIGRinDKTTAEELQRLDKSSNNDQLIESSLFIDIAntsmILRDIRSDSDSLSRDDISDLLFKq 173
Cdd:TIGR00324   1 EIQGKLKGDEVIVKKKTIIS--DLTTREEYGNLDGDSLNLSLIESLYLIDLG----KLRLIRSDSEPLSREELSDLARK- 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 760030155  174 yRQAGKMQTYFLYKALRDQGYVLSPGGRFGGKFIAYPGDPLRFHSHLTIQDAIDYHNEPIDLISMISGARLGTTVKKLWV 253
Cdd:TIGR00324  74 -VERGFMRKYLVYKDLRDRGYVVKTGFKFGADFRLYERGPLRDHSHSEYLVAIDDHDESIDLIDLSSGVRVAHGVKKKLV 152

                         170
                  ....*....|....*....
gi 760030155  254 IGGVAEEtKETHFFSIEWA 272
Cdd:TIGR00324 153 IAYVDEE-KEIHYLSIEWV 170
tRNA-intron_lyase_C cd22363
catalytic C-terminal domain of the tRNA-intron lyase; This C-terminal catalytic domain of tRNA ...
 183-271 5.64e-20

catalytic C-terminal domain of the tRNA-intron lyase; This C-terminal catalytic domain of tRNA intron endonucleases cleaves pre tRNA at the 5' and 3' splice sites to release the intron (EC:3.1.27.9). It belongs to a superfamily of nucleases including very short patch repair (Vsr) endonucleases, archaeal Holliday junction resolvases, MutH methyl-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and FokI.


Pssm-ID: 411767  Cd Length: 91  Bit Score: 82.15  E-value: 5.64e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 760030155 183 YFLYKALRDQGYVLSPGGRFGGKFIAYPGDPLRFHSHLTIQdaIDYHNEPIDLISMISGARLGTTVKKLWVIGGVaEETK 262
Cdd:cd22363    6 YLVYKDLRSRGYVVKSGFKFGADFLVYPRGPGLYHAKYLVH--VVPEDEELSWLELVRAGRLAHSVKKTLVLAVV-DEEG 82


                 ....*....
gi 760030155 263 ETHFFSIEW 271
Cdd:cd22363   83 EVTYYSIEW 91
tRNA_int_endo pfam01974
tRNA intron endonuclease, catalytic C-terminal domain; Members of this family cleave pre tRNA ...
 183-260 6.15e-15

tRNA intron endonuclease, catalytic C-terminal domain; Members of this family cleave pre tRNA at the 5' and 3' splice sites to release the intron EC:3.1.27.9.


Pssm-ID: 396521  Cd Length: 85  Bit Score: 68.44  E-value: 6.15e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 760030155  183 YFLYKALRDQGYVLSPGGRFGGKFIAYPGDPLRFHSHLTIQdAIDYhNEPIDLISMISGARLGTTVKKLWVIGGVAEE 260
Cdd:pfam01974   5 YLVYRDLRERGYVVKPGIKFGADFRVYGGGPGKGHSEYLVR-VLSE-DDPISLLDLLRAVRLAHSVRKELVLAIVDDE 80
SEN2 COG1676
tRNA splicing endonuclease subunit SEN34 [Translation, ribosomal structure and biogenesis]; ...
 183-271 1.65e-06

tRNA splicing endonuclease subunit SEN34 [Translation, ribosomal structure and biogenesis]; tRNA splicing endonuclease subunit SEN34 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441282  Cd Length: 173  Bit Score: 47.12  E-value: 1.65e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 760030155 183 YFLYKALRDQGYVLSPGGRFGGKFIAYPGDPLRF-HSHLTIQdAIDYhNEPIDLISMISGARLGTTVKKLWVIgGVAEET 261
Cdd:COG1676   84 YLVYRDLRDRGYVVKTGFKFGSDFRVYERGPGIEdHSPYLVH-VVPE-GTEFSPRELSRAVRLAHSVRKRMVF-AVVDDE 160

                         90
                 ....*....|
gi 760030155 262 KETHFFSIEW 271
Cdd:COG1676  161 GEIEYYKFEW 170
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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