|
Name |
Accession |
Description |
Interval |
E-value |
| AKR_AKR9A3_9B1-4 |
cd19147 |
Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; ... |
1-250 |
0e+00 |
|
Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; Phanerochaete chrysosporium ADD (EC1.1.1.91) is a founding member of aldo-keto reductase family 9 member A3. It is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). This family also includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.
Pssm-ID: 381373 [Multi-domain] Cd Length: 319 Bit Score: 533.25 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 1 MASRKLRDQVVIATKFTTDYKGYDVGKGKSANFCGNHKRSLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEVMDSLHI 80
Cdd:cd19147 70 MKSRKNRDQIVIATKFTTDYKAYEVGKGKAVNYCGNHKRSLHVSVRDSLRKLQTDWIDILYVHWWDYTTSIEEVMDSLHI 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 81 LVQQGKVLYLGVSDTPAWVVSAANYYATSHGKTPFSIYQGKWNVLNRDFERDIIPMARHFGMALAPWDVMGGGRFQSKKA 160
Cdd:cd19147 150 LVQQGKVLYLGVSDTPAWVVSAANYYATAHGKTPFSVYQGRWNVLNRDFERDIIPMARHFGMALAPWDVLGGGKFQSKKA 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 161 VEERKKKGEGLRTFFGTSEQTDMEVKISEALLKVAEEHGTESVTAIAIAYVRSKAKHVFPLVGGRKIEHLKQNIEALSIK 240
Cdd:cd19147 230 VEERKKNGEGLRSFVGGTEQTPEEVKISEALEKVAEEHGTESVTAIALAYVRSKAPNVFPLVGGRKIEHLKDNIEALSIK 309
|
250
....*....|
gi 766431913 241 LTPEQIKYLE 250
Cdd:cd19147 310 LTPEEIEYLE 319
|
|
| AKR_AKR9A1-2 |
cd19146 |
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus ... |
1-264 |
5.46e-138 |
|
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and similar proteins; Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV and Aspergillus flavus norsolorinic acid reductase (NOR), are founding members of aldo-keto reductase family 9 member A1-2 (AKR9A1-2), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis.
Pssm-ID: 381372 [Multi-domain] Cd Length: 326 Bit Score: 392.17 E-value: 5.46e-138
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 1 MASRKLRDQVVIATKFTTDYKGYDVGKGKSaNFCGNHKRSLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEVMDSLHI 80
Cdd:cd19146 71 MASRGNRDEMVLATKYTTGYRRGGPIKIKS-NYQGNHAKSLRLSVEASLKKLQTSYIDILYVHWWDYTTSIPELMQSLNH 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 81 LVQQGKVLYLGVSDTPAWVVSAANYYATSHGKTPFSIYQGKWNVLNRDFERDIIPMARHFGMALAPWDVMGGGRFQSKka 160
Cdd:cd19146 150 LVAAGKVLYLGVSDTPAWVVSKANAYARAHGLTQFVVYQGHWSAAFRDFERDILPMCEAEGMALAPWGVLGQGQFRTE-- 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 161 vEERKKKGeglRTFFGTSEQTDMEVKISEALLKVAEEHGTeSVTAIAIAYVRSKAKHVFPLVGGRKIEHLKQNIEALSIK 240
Cdd:cd19146 228 -EEFKRRG---RSGRKGGPQTEKERKVSEKLEKVAEEKGT-AITSVALAYVMHKAPYVFPIVGGRKVEHLKGNIEALGIS 302
|
250 260
....*....|....*....|....
gi 766431913 241 LTPEQIKYLESIVPFDVGFPTNFI 264
Cdd:cd19146 303 LSDEEIQEIEDAYPFDVGFPMNFL 326
|
|
| AKR_AKR9A_9B |
cd19080 |
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus ... |
4-250 |
3.98e-126 |
|
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD), are founding members of aldo-keto reductase family 9 member A1-3 (AKR9A1-3), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis. AAD (EC1.1.1.91) is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). The AKR9B family includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.
Pssm-ID: 381306 [Multi-domain] Cd Length: 307 Bit Score: 361.54 E-value: 3.98e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 4 RKLRDQVVIATKFTTDYKGYDVgkgksaNFCGNHKRSLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEVMDSLHILVQ 83
Cdd:cd19080 68 AGNRDRIVLATKYTMNRRPGDP------NAGGNHRKNLRRSVEASLRRLQTDYIDLLYVHAWDFTTPVEEVMRALDDLVR 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 84 QGKVLYLGVSDTPAWVVSAANYYATSHGKTPFSIYQGKWNVLNRDFERDIIPMARHFGMALAPWDVMGGGRFQSKKAVEE 163
Cdd:cd19080 142 AGKVLYVGISDTPAWVVARANTLAELRGWSPFVALQIEYSLLERTPERELLPMARALGLGVTPWSPLGGGLLTGKYQRGE 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 164 RKKKGEGLRTFFGTSEQTDMEVKISEALLKVAEEHGTeSVTAIAIAYVRSKAKHVFPLVGGRKIEHLKQNIEALSIKLTP 243
Cdd:cd19080 222 EGRAGEAKGVTVGFGKLTERNWAIVDVVAAVAEELGR-SAAQVALAWVRQKPGVVIPIIGARTLEQLKDNLGALDLTLSP 300
|
....*..
gi 766431913 244 EQIKYLE 250
Cdd:cd19080 301 EQLARLD 307
|
|
| PdxI |
COG0667 |
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme ... |
7-254 |
2.46e-68 |
|
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme transport and metabolism, General function prediction only];
Pssm-ID: 440431 [Multi-domain] Cd Length: 316 Bit Score: 214.66 E-value: 2.46e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 7 RDQVVIATKFttdykGYDVGKGKsaNFCGNHKRSLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEVMDSLHILVQQGK 86
Cdd:COG0667 74 RDDVVIATKV-----GRRMGPGP--NGRGLSREHIRRAVEASLRRLGTDYIDLYQLHRPDPDTPIEETLGALDELVREGK 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 87 VLYLGVSDTPAWVVSAANyyATSHGKTPFSIYQGKWNVLNRDFERDIIPMARHFGMALAPWDVMGGGRFQSKKAVEERKK 166
Cdd:COG0667 147 IRYIGVSNYSAEQLRRAL--AIAEGLPPIVAVQNEYSLLDRSAEEELLPAARELGVGVLAYSPLAGGLLTGKYRRGATFP 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 167 KGEGLRTFFGTSEQTDMEVKISEALLKVAEEHGTeSVTAIAIAYVRSKAKHVFPLVGGRKIEHLKQNIEALSIKLTPEQI 246
Cdd:COG0667 225 EGDRAATNFVQGYLTERNLALVDALRAIAAEHGV-TPAQLALAWLLAQPGVTSVIPGARSPEQLEENLAAADLELSAEDL 303
|
....*...
gi 766431913 247 KYLESIVP 254
Cdd:COG0667 304 AALDAALA 311
|
|
| AKR_EcYajO-like |
cd19079 |
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this ... |
7-250 |
1.63e-65 |
|
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381305 [Multi-domain] Cd Length: 312 Bit Score: 207.44 E-value: 1.63e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 7 RDQVVIATKFttdykGYDVGKGksANFCGNHKRSLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEVMDSLHILVQQGK 86
Cdd:cd19079 77 RDEVVIATKV-----YFPMGDG--PNGRGLSRKHIMAEVDASLKRLGTDYIDLYQIHRWDYETPIEETLEALHDVVKSGK 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 87 VLYLGVSDTPAWVVSAANYYATSHGKTPFSIYQGKWNVLNRDFERDIIPMARHFGMALAPWDVMGGGRFQSKKAVEERKK 166
Cdd:cd19079 150 VRYIGASSMYAWQFAKALHLAEKNGWTKFVSMQNHYNLLYREEEREMIPLCEEEGIGVIPWSPLARGRLARPWGDTTERR 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 167 KGEGLRTFFGTSEQTDMEVKISEALLKVAEEHGTeSVTAIAIAYVRSKAKHVFPLVGGRKIEHLKQNIEALSIKLTPEQI 246
Cdd:cd19079 230 RSTTDTAKLKYDYFTEADKEIVDRVEEVAKERGV-SMAQVALAWLLSKPGVTAPIVGATKLEHLEDAVAALDIKLSEEEI 308
|
....
gi 766431913 247 KYLE 250
Cdd:cd19079 309 KYLE 312
|
|
| Aldo_ket_red |
pfam00248 |
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ... |
7-253 |
1.23e-63 |
|
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.
Pssm-ID: 425554 [Multi-domain] Cd Length: 290 Bit Score: 201.77 E-value: 1.23e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 7 RDQVVIATKfttdykgydVGKGKSANFCGNHKRSLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEVMDSLHILVQQGK 86
Cdd:pfam00248 61 RDKVVIATK---------VPDGDGPWPSGGSKENIRKSLEESLKRLGTDYIDLYYLHWPDPDTPIEETWDALEELKKEGK 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 87 VLYLGVSDTPAWVVSaanyYATSHGKTPFSIYQGKWNVLNRDFERDIIPMARHFGMALAPWDVMGGGRFQSKKAVEERKK 166
Cdd:pfam00248 132 IRAIGVSNFDAEQIE----KALTKGKIPIVAVQVEYNLLRRRQEEELLEYCKKNGIPLIAYSPLGGGLLTGKYTRDPDKG 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 167 KGEGLRTFfgtSEQTDMEVKISEALLKVAEEHGtESVTAIAIAYVRSKAKHVFPLVGGRKIEHLKQNIEALSIKLTPEQI 246
Cdd:pfam00248 208 PGERRRLL---KKGTPLNLEALEALEEIAKEHG-VSPAQVALRWALSKPGVTIPIPGASNPEQLEDNLGALEFPLSDEEV 283
|
....*..
gi 766431913 247 KYLESIV 253
Cdd:pfam00248 284 ARIDELL 290
|
|
| AKR_PsAKR |
cd19091 |
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an ... |
2-252 |
4.04e-61 |
|
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an uncharacterized aldo-keto reductase from Polaromonas sp.
Pssm-ID: 381317 [Multi-domain] Cd Length: 319 Bit Score: 196.29 E-value: 4.04e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 2 ASRKLRDQVVIATKFttdykGYDVGKGksANFCGNHKRSLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEVMDSLHIL 81
Cdd:cd19091 74 ALKGRRDDVLIATKV-----RGRMGEG--PNDVGLSRHHIIRAVEASLKRLGTDYIDLYQLHGFDALTPLEETLRALDDL 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 82 VQQGKVLYLGVSDTPAWVVSAANYYATSHGKTPFSIYQGKWNVLNRDFERDIIPMARHFGMALAPWDVMGGGRFQSKKAV 161
Cdd:cd19091 147 VRQGKVRYIGVSNFSAWQIMKALGISERRGLARFVALQAYYSLLGRDLEHELMPLALDQGVGLLVWSPLAGGLLSGKYRR 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 162 EERKKKGEGLRTFFGTSEQTDME--VKISEALLKVAEEHGTeSVTAIAIAYVRSKAKHVFPLVGGRKIEHLKQNIEALSI 239
Cdd:cd19091 227 GQPAPEGSRLRRTGFDFPPVDRErgYDVVDALREIAKETGA-TPAQVALAWLLSRPTVSSVIIGARNEEQLEDNLGAAGL 305
|
250
....*....|...
gi 766431913 240 KLTPEQIKYLESI 252
Cdd:cd19091 306 SLTPEEIARLDKV 318
|
|
| AKR_AKR9C1 |
cd19081 |
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a ... |
1-249 |
8.03e-55 |
|
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a founding member of aldo-keto reductase family 9 member C1 (AKR9C1).
Pssm-ID: 381307 [Multi-domain] Cd Length: 308 Bit Score: 179.72 E-value: 8.03e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 1 MASRKLRDQVVIATKfttdykgydVGKGKSANFCGNHKRSLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEVMDSLHI 80
Cdd:cd19081 69 LKSRGKRDRVVIATK---------VGFPMGPNGPGLSRKHIRRAVEASLRRLQTDYIDLYQAHWDDPATPLEETLGALND 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 81 LVQQGKVLYLGVSDTPAWVVSAANYYATSHGKTPFSIYQGKWNVLNRD-FERDIIPMARHFGMALAPWDVMGG----GRF 155
Cdd:cd19081 140 LIRQGKVRYIGASNYSAWRLQEALELSRQHGLPRYVSLQPEYNLVDREsFEGELLPLCREEGIGVIPYSPLAGgfltGKY 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 156 QSKKAVEERKKKGEGLRTFFgtseqTDMEVKISEALLKVAEEHGTeSVTAIAIAYVRSKAKHVFPLVGGRKIEHLKQNIE 235
Cdd:cd19081 220 RSEADLPGSTRRGEAAKRYL-----NERGLRILDALDEVAAEHGA-TPAQVALAWLLARPGVTAPIAGARTVEQLEDLLA 293
|
250
....*....|....
gi 766431913 236 ALSIKLTPEQIKYL 249
Cdd:cd19081 294 AAGLRLTDEEVARL 307
|
|
| AKR_SF |
cd06660 |
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ... |
1-235 |
9.75e-54 |
|
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.
Pssm-ID: 381296 [Multi-domain] Cd Length: 232 Bit Score: 174.63 E-value: 9.75e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 1 MASRKLRDQVVIATKFttdykGYDVGKGKSAnfCGNHKRSLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEVMDSLHI 80
Cdd:cd06660 53 LKGRGNRDDVVIATKG-----GHPPGGDPSR--SRLSPEHIRRDLEESLRRLGTDYIDLYYLHRDDPSTPVEETLEALNE 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 81 LVQQGKVLYLGVSDTPAWVVSAANYYATSHGKTPFSIYQGKWNVLNRDF-ERDIIPMARHFGMALAPWDVMGGGrfqskk 159
Cdd:cd06660 126 LVREGKIRYIGVSNWSAERLAEALAYAKAHGLPGFAAVQPQYSLLDRSPmEEELLDWAEENGLPLLAYSPLARG------ 199
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 766431913 160 aveerkkkgeglrtffgtseqtdmevkiseallkvaeehgtesVTAIAIAYVRSKAKHVFPLVGGRKIEHLKQNIE 235
Cdd:cd06660 200 -------------------------------------------PAQLALAWLLSQPFVTVPIVGARSPEQLEENLA 232
|
|
| AKR_AKR12A1_B1_C1 |
cd19087 |
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, ... |
7-254 |
2.19e-53 |
|
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, Saccharopolyspora erythraea EryBII, and Streptomyces avermitilis aveBVIII are founding members of aldo-keto reductase family 12 member A1 (AKR12A1), B1 (AKR12B1), and C1(AKR12C1), respectively. TylCII acts as a NDP-hexose 2,3-enoyl reductase. EryBII is a mycarose/desosamine reductase involved in L-mycarose and D-desosamine production. aveBVIII functions as a dTDP-4-keto-6-deoxy-L-hexose-2,3-reductase.
Pssm-ID: 381313 [Multi-domain] Cd Length: 310 Bit Score: 176.22 E-value: 2.19e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 7 RDQVVIATKFttdykGYDVGKGKSANfcGNHKRSLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEVMDSLHILVQQGK 86
Cdd:cd19087 70 RDDIVLATKV-----FGPMGDDPNDR--GLSRRHIRRAVEASLRRLQTDYIDLYQMHHFDRDTPLEETLRALDDLVRQGK 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 87 VLYLGVSDTPAWVVSAANYYATSHGKTPFSIYQGKWNVLNRDFERDIIPMARHFGMALAPWDVMGGGRFQSKKAVEERKK 166
Cdd:cd19087 143 IRYIGVSNFAAWQIAKAQGIAARRGLLRFVSEQPMYNLLKRQAELEILPAARAYGLGVIPYSPLAGGLLTGKYGKGKRPE 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 167 KGEGL-RTFFGTSEQTDMEVKISEALLKVAEEHGtESVTAIAIAYVRSKAKHVFPLVGGRKIEHLKQNIEALSIKLTPEQ 245
Cdd:cd19087 223 SGRLVeRARYQARYGLEEYRDIAERFEALAAEAG-LTPASLALAWVLSHPAVTSPIIGPRTLEQLEDSLAALEITLTPEL 301
|
....*....
gi 766431913 246 IKYLESIVP 254
Cdd:cd19087 302 LAEIDELFP 310
|
|
| AKR_AKR11B1-like |
cd19084 |
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called ... |
2-250 |
2.22e-49 |
|
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381310 [Multi-domain] Cd Length: 296 Bit Score: 165.39 E-value: 2.22e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 2 ASRKLRDQVVIATKFttdykGYDVGKGKSANFCGNHKrSLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEVMDSLHIL 81
Cdd:cd19084 60 ALKGRRDDVVIATKC-----GLRWDGGKGVTKDLSPE-SIRKEVEQSLRRLQTDYIDLYQIHWPDPNTPIEETAEALEKL 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 82 VQQGKVLYLGVSDTPAWVVSAANYYAtshgktPFSIYQGKWNVLNRDFERDIIPMARHFGMALAPWDVMGGG----RFQs 157
Cdd:cd19084 134 KKEGKIRYIGVSNFSVEQLEEARKYG------PIVSLQPPYSMLEREIEEELLPYCRENGIGVLPYGPLAQGlltgKYK- 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 158 kkavEERKKKGEGLRTFFGT--SEQTDMEVKISEALLKVAEEHGtESVTAIAIAYVRSKAKHVFPLVGGRKIEHLKQNIE 235
Cdd:cd19084 207 ----KEPTFPPDDRRSRFPFfrGENFEKNLEIVDKLKEIAEKYG-KSLAQLAIAWTLAQPGVTSAIVGAKNPEQLEENAG 281
|
250
....*....|....*
gi 766431913 236 ALSIKLTPEQIKYLE 250
Cdd:cd19084 282 ALDWELTEEELKEID 296
|
|
| AKR_Tas-like |
cd19094 |
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the ... |
1-244 |
1.55e-40 |
|
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the prototype of this family. It is an NADP(H)-dependent aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NADP(H) as a hydride donor.
Pssm-ID: 381320 [Multi-domain] Cd Length: 328 Bit Score: 143.09 E-value: 1.55e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 1 MASRKLRDQVVIATKFTTDYKGYDVGKGKSANFCGNHKRSlhvSVRDSLRKLQTDWIDILYVHWWD-------------- 66
Cdd:cd19094 61 LKKKGNRDKVVLATKVAGPGEGITWPRGGGTRLDRENIRE---AVEGSLKRLGTDYIDLYQLHWPDrytplfgggyytep 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 67 ---YMS-SIEEVMDSLHILVQQGKVLYLGVSDTPAWVVSAANYYATSHGKTPF-SIyQGKWNVLNRDFERDIIPMARHFG 141
Cdd:cd19094 138 seeEDSvSFEEQLEALGELVKAGKIRHIGLSNETPWGVMKFLELAEQLGLPRIvSI-QNPYSLLNRNFEEGLAEACHREN 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 142 MALAPWDVMGGGRFQSKKAVEERKKKGEGLRTFFGT-----SEQTDMEVKiseALLKVAEEHGTeSVTAIAIAYVRSKak 216
Cdd:cd19094 217 VGLLAYSPLAGGVLTGKYLDGAARPEGGRLNLFPGYmaryrSPQALEAVA---EYVKLARKHGL-SPAQLALAWVRSR-- 290
|
250 260 270
....*....|....*....|....*....|...
gi 766431913 217 hvfPLV-----GGRKIEHLKQNIEALSIKLTPE 244
Cdd:cd19094 291 ---PFVtstiiGATTLEQLKENIDAFDVPLSDE 320
|
|
| AKR_AKR10A1_2 |
cd19082 |
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) ... |
1-238 |
3.58e-37 |
|
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) and Streptomyces glaucescens aldo-keto reductase (StrT) are founding members of aldo-keto reductase family 10 member A1 (AKR10A1) and A2 (AKR10A2). BlmT is bluensomycin aldo-keto reductase (AKR) and StrT is streptomycin AKR.
Pssm-ID: 381308 [Multi-domain] Cd Length: 291 Bit Score: 133.45 E-value: 3.58e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 1 MASRKLRDQVVIATKfttdyKGYDVGKGKSANFCgnHKRSLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEVMDSLHI 80
Cdd:cd19082 57 LKSRGNRDKVVIATK-----GGHPDLEDMSRSRL--SPEDIRADLEESLERLGTDYIDLYFLHRDDPSVPVGEIVDTLNE 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 81 LVQQGKVLYLGVSDtpaWV---VSAANYYATSHGKTPFSIYQGKWN--VLNRDFERD--IIPM---ARHF----GMALAP 146
Cdd:cd19082 130 LVRAGKIRAFGASN---WSterIAEANAYAKAHGLPGFAASSPQWSlaRPNEPPWPGptLVAMdeeMRAWheenQLPVFA 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 147 WDVMGGGRFqSKKAVEERKKKGEGLRTFFgtseqTDMEVKISEALLKVAEEHGTeSVTAIAIAYVRSKAKHVFPLVGGRK 226
Cdd:cd19082 207 YSSQARGFF-SKRAAGGAEDDSELRRVYY-----SEENFERLERAKELAEEKGV-SPTQIALAYVLNQPFPTVPIIGPRT 279
|
250
....*....|..
gi 766431913 227 IEHLKQNIEALS 238
Cdd:cd19082 280 PEQLRDSLAAAD 291
|
|
| Aldo_ket_red_shaker-like |
cd19074 |
Shaker potassium channel beta subunit family and similar proteins; This family includes ... |
7-244 |
5.28e-35 |
|
Shaker potassium channel beta subunit family and similar proteins; This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. The family also includes Drosophila melanogaster Hk protein, a founding member of aldo-keto reductase family 6 member B1 (AKR6B1), as well as voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa, founding members of AKR6C1and AKR6C2, respectively. Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381300 [Multi-domain] Cd Length: 297 Bit Score: 127.71 E-value: 5.28e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 7 RDQVVIATK--FTTDYKGYDVGKGKsanfcgNHkrsLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEVMDSLHILVQQ 84
Cdd:cd19074 63 RESYVISTKvfWPTGPGPNDRGLSR------KH---IFESIHASLKRLQLDYVDIYYCHRYDPETPLEETVRAMDDLIRQ 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 85 GKVLYLGVSDTPAWVVSAANYYATSHGKTPFSIYQGKWNVLNRDFERDIIPMARHFGMALAPWDVMGGG----RFQSKKA 160
Cdd:cd19074 134 GKILYWGTSEWSAEQIAEAHDLARQFGLIPPVVEQPQYNMLWREIEEEVIPLCEKNGIGLVVWSPLAQGlltgKYRDGIP 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 161 VEERKKKGEGLRTFFGTSEQTDMEVKISEALLKVAEEHGTeSVTAIAIAYVRSKAKHVFPLVGGRKIEHLKQNIEALSIK 240
Cdd:cd19074 214 PPSRSRATDEDNRDKKRRLLTDENLEKVKKLKPIADELGL-TLAQLALAWCLRNPAVSSAIIGASRPEQLEENVKASGVK 292
|
....
gi 766431913 241 LTPE 244
Cdd:cd19074 293 LSPE 296
|
|
| AKR_AKR11B3 |
cd19085 |
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is ... |
4-252 |
1.27e-34 |
|
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is a founding member of aldo-keto reductase family 11 member B3(AKR11B3). It is responsible for methylglyoxal detoxification.
Pssm-ID: 381311 [Multi-domain] Cd Length: 292 Bit Score: 126.55 E-value: 1.27e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 4 RKLRDQVVIATKFTTDYKGYDvgkgksanfcgnhkrSLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEVMDSLHILVQ 83
Cdd:cd19085 60 KGRRDDVVIATKVSPDNLTPE---------------DVRKSCERSLKRLGTDYIDLYQIHWPSSDVPLEETMEALEKLKE 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 84 QGKVLYLGVSDTPAWvvsaanYYATSHGKTPFSIYQGKWNVLNRDFERDIIPMARHFGMALAPWDVMG----GGRFQSKK 159
Cdd:cd19085 125 EGKIRAIGVSNFGPA------QLEEALDAGRIDSNQLPYNLLWRAIEYEILPFCREHGIGVLAYSPLAqgllTGKFSSAE 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 160 AVEERKKKGEGLRTFF-GTSEQTdmeVKISEALLKVAEEHGTeSVTAIAIAYVRSKAKHVFPLVGGRKIEHLKQNIEALS 238
Cdd:cd19085 199 DFPPGDARTRLFRHFEpGAEEET---FEALEKLKEIADELGV-TMAQLALAWVLQQPGVTSVIVGARNPEQLEENAAAVD 274
|
250
....*....|....
gi 766431913 239 IKLTPEQIKYLESI 252
Cdd:cd19085 275 LELSPSVLERLDEI 288
|
|
| AKR_AKR13A_13D |
cd19076 |
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto ... |
2-249 |
3.08e-34 |
|
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381302 [Multi-domain] Cd Length: 303 Bit Score: 125.79 E-value: 3.08e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 2 ASRKLRDQVVIATKFttdykGYDVGKGksANFCGNHKRSLHV--SVRDSLRKLQTDWIDILYVHWWDYMSSIEEVMDSLH 79
Cdd:cd19076 67 ALKDRRDEVVIATKF-----GIVRDPG--SGFRGVDGRPEYVraACEASLKRLGTDVIDLYYQHRVDPNVPIEETVGAMA 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 80 ILVQQGKVLYLGVSDtpawvvSAANYYATSHGKTPFSIYQGKWNVLNRDFERDIIPMARHFGMALAPWDVMGGGRFQSKK 159
Cdd:cd19076 140 ELVEEGKVRYIGLSE------ASADTIRRAHAVHPITAVQSEYSLWTRDIEDEVLPTCRELGIGFVAYSPLGRGFLTGAI 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 160 AVEERKKKGEGLRTF--FgTSEQTDMEVKISEALLKVAEEHGtesVTA--IAIAYVRSKAKHVFPLVGGRKIEHLKQNIE 235
Cdd:cd19076 214 KSPEDLPEDDFRRNNprF-QGENFDKNLKLVEKLEAIAAEKG---CTPaqLALAWVLAQGDDIVPIPGTKRIKYLEENVG 289
|
250
....*....|....
gi 766431913 236 ALSIKLTPEQIKYL 249
Cdd:cd19076 290 ALDVVLTPEELAEI 303
|
|
| AKR_AKR13D1 |
cd19145 |
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of ... |
7-249 |
3.83e-34 |
|
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381371 [Multi-domain] Cd Length: 304 Bit Score: 125.62 E-value: 3.83e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 7 RDQVVIATKFTTDYKGydvgkgksanFCGNHKRSLHVSVR----DSLRKLQTDWIDILYVHWWDYMSSIEEVMDSLHILV 82
Cdd:cd19145 74 REKVQLATKFGIHEIG----------GSGVEVRGDPAYVRaaceASLKRLDVDYIDLYYQHRIDTTVPIEITMGELKKLV 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 83 QQGKVLYLGVSDTPAWVVSAAnyyatsHGKTPFSIYQGKWNVLNRDFERDIIPMARHFGMALAPWDVMGGGRFQSKKAVE 162
Cdd:cd19145 144 EEGKIKYIGLSEASADTIRRA------HAVHPITAVQLEWSLWTRDIEEEIIPTCRELGIGIVPYSPLGRGFFAGKAKLE 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 163 ERKKKGEGLRTF--FgTSEQTDMEVKISEALLKVAEEHGTeSVTAIAIAYVRSKAKHVFPLVGGRKIEHLKQNIEALSIK 240
Cdd:cd19145 218 ELLENSDVRKSHprF-QGENLEKNKVLYERVEALAKKKGC-TPAQLALAWVLHQGEDVVPIPGTTKIKNLNQNIGALSVK 295
|
....*....
gi 766431913 241 LTPEQIKYL 249
Cdd:cd19145 296 LTKEDLKEI 304
|
|
| AKR_AKR11B2 |
cd19149 |
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; ... |
2-251 |
1.81e-32 |
|
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381375 [Multi-domain] Cd Length: 315 Bit Score: 121.61 E-value: 1.81e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 2 ASRKLRDQVVIATKF-----TTDYKGYDVGKGKSANFCGNhKRSLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEVMD 76
Cdd:cd19149 68 AIKGRRDKVVLATKCglrwdREGGSFFFVRDGVTVYKNLS-PESIREEVEQSLKRLGTDYIDLYQTHWQDVETPIEETME 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 77 SLHILVQQGKVLYLGVSDTPAWVVSAANYYAtshgktPFSIYQGKWNVLNRDFERDIIPMARHFGMALAPWDVMGGGrFQ 156
Cdd:cd19149 147 ALEELKRQGKIRAIGASNVSVEQIKEYVKAG------QLDIIQEKYSMLDRGIEKELLPYCKKNNIAFQAYSPLEQG-LL 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 157 SKKAVEERKKKGEGLRTFFGTSEQTDME--VKISEALLKVAEEHGTeSVTAIAIAYVRSKAKHVFPLVGGRKIEHLKQNI 234
Cdd:cd19149 220 TGKITPDREFDAGDARSGIPWFSPENREkvLALLEKWKPLCEKYGC-TLAQLVIAWTLAQPGITSALCGARKPEQAEENA 298
|
250
....*....|....*..
gi 766431913 235 EALSIKLTPEQIKYLES 251
Cdd:cd19149 299 KAGDIRLSAEDIATMRS 315
|
|
| AKR_AKR13C1_2 |
cd19078 |
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli ... |
7-251 |
2.42e-31 |
|
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli aldehyde reductase (AKR13C1) and Thermotoga maritima aldo-keto reductase (AKR13C2). Aldehyde reductase (EC 1.1.1.21), also called aldose reductase, is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides.
Pssm-ID: 381304 [Multi-domain] Cd Length: 301 Bit Score: 118.10 E-value: 2.42e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 7 RDQVVIATKFttdykGYDVGKGKSANFCGNhKRSLHV--SVRDSLRKLQTDWIDILYVHWWDYMSSIEEVMDSLHILVQQ 84
Cdd:cd19078 65 RDQVVIATKF-----GFKIDGGKPGPLGLD-SRPEHIrkAVEGSLKRLQTDYIDLYYQHRVDPNVPIEEVAGTMKELIKE 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 85 GKVLYLGVSDTpawvvsAANYYATSHGKTPFSIYQGKWNVLNRDFERDIIPMARHFGMALAPWDVMGGGrFQSKKAVEER 164
Cdd:cd19078 139 GKIRHWGLSEA------GVETIRRAHAVCPVTAVQSEYSMMWREPEKEVLPTLEELGIGFVPFSPLGKG-FLTGKIDENT 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 165 KKKGEGLR---TFFgTSEQTDMEVKISEALLKVAEEHGTESVtAIAIAYVRSKAKHVFPLVGGRKIEHLKQNIEALSIKL 241
Cdd:cd19078 212 KFDEGDDRaslPRF-TPEALEANQALVDLLKEFAEEKGATPA-QIALAWLLAKKPWIVPIPGTTKLSRLEENIGAADIEL 289
|
250
....*....|
gi 766431913 242 TPEQIKYLES 251
Cdd:cd19078 290 TPEELREIED 299
|
|
| AKR_AKR3F1-like |
cd19072 |
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime ... |
7-250 |
2.62e-29 |
|
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase. Escherichia coli YeaE may act as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381298 [Multi-domain] Cd Length: 263 Bit Score: 111.94 E-value: 2.62e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 7 RDQVVIATKFTTDYKGYDvgkgksanfcgnhkrSLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEVMDSLHILVQQGK 86
Cdd:cd19072 67 REDLFITTKVSPDHLKYD---------------DVIKAAKESLKRLGTDYIDLYLIHWPNPSIPIEETLRAMEELVEEGK 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 87 VLYLGVSDTPAWVVSAANYYAtshGKTPFSIYQGKWNVLNRDFERDIIPMARHFGMALAPWDVMGGGRFQSKKAVEErkk 166
Cdd:cd19072 132 IRYIGVSNFSLEELEEAQSYL---KKGPIVANQVEYNLFDREEESGLLPYCQKNGIAIIAYSPLEKGKLSNAKGSPL--- 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 167 kgeglrtffgtseqtdmevkiseaLLKVAEEHGtESVTAIAIAYVRSKaKHVFPLVGGRKIEHLKQNIEALSIKLTPEQI 246
Cdd:cd19072 206 ------------------------LDEIAKKYG-KTPAQIALNWLISK-PNVIAIPKASNIEHLEENAGALGWELSEEDL 259
|
....
gi 766431913 247 KYLE 250
Cdd:cd19072 260 QRLD 263
|
|
| YdhF |
COG4989 |
Predicted oxidoreductase YdhF [General function prediction only]; |
6-245 |
2.67e-28 |
|
Predicted oxidoreductase YdhF [General function prediction only];
Pssm-ID: 444013 [Multi-domain] Cd Length: 299 Bit Score: 110.24 E-value: 2.67e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 6 LRDQVVIATK----FTTDYKGYDVgkgKSANFCGNHkrsLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEVMDSLHIL 81
Cdd:COG4989 73 LREKIELQTKcgirLPSEARDNRV---KHYDTSKEH---IIASVEGSLRRLGTDYLDLLLLHRPDPLMDPEEVAEAFDEL 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 82 VQQGKVLYLGVSDTPAWVVSAANyyatSHGKTPFSIYQGKWNVLNRD-FERDIIPMARHFGMALAPWDVMGGGRFqskka 160
Cdd:COG4989 147 KASGKVRHFGVSNFTPSQFELLQ----SALDQPLVTNQIELSLLHTDaFDDGTLDYCQLNGITPMAWSPLAGGRL----- 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 161 veerkkkgeglrtFFGTSEQTdmeVKISEALLKVAEEHGTeSVTAIAIAYVRskaKH---VFPLVGGRKIEHLKQNIEAL 237
Cdd:COG4989 218 -------------FGGFDEQF---PRLRAALDELAEKYGV-SPEAIALAWLL---RHpagIQPVIGTTNPERIKAAAAAL 277
|
....*...
gi 766431913 238 SIKLTPEQ 245
Cdd:COG4989 278 DIELTREE 285
|
|
| AKR_AtPLR-like |
cd19093 |
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR ... |
5-250 |
8.32e-28 |
|
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR (EC 1.1.1.65) is the prototype of this family. It catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+), and is involved in the PLP salvage pathway.
Pssm-ID: 381319 [Multi-domain] Cd Length: 293 Bit Score: 108.47 E-value: 8.32e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 5 KLRDQVVIATKFttdykgydvgkgkSANFCGNHKRSLHVSVRDSLRKLQTDWIDILYVHW-WDYMSSIEEVMDSLHILVQ 83
Cdd:cd19093 66 GDRDEVVIATKF-------------APLPWRLTRRSVVKALKASLERLGLDSIDLYQLHWpGPWYSQIEALMDGLADAVE 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 84 QGKVLYLGVSDTPAWVVSAANYYATSHGKTPFSIyQGKWNVLNRDFERD-IIPMARHFGMALAPWDVMGGGRFQSKKAVE 162
Cdd:cd19093 133 EGLVRAVGVSNYSADQLRRAHKALKERGVPLASN-QVEYSLLYRDPEQNgLLPACDELGITLIAYSPLAQGLLTGKYSPE 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 163 ERKKKGEGLRTFFGTSEQTDmevKISEALLKVAEEHGtESVTAIAIAYVRSKAkhVFPLVGGRKIEHLKQNIEALSIKLT 242
Cdd:cd19093 212 NPPPGGRRRLFGRKNLEKVQ---PLLDALEEIAEKYG-KTPAQVALNWLIAKG--VVPIPGAKNAEQAEENAGALGWRLS 285
|
....*...
gi 766431913 243 PEQIKYLE 250
Cdd:cd19093 286 EEEVAELD 293
|
|
| AKR_AKR14A1_2 |
cd19089 |
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate ... |
4-247 |
2.24e-27 |
|
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo. Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2). It catalyzes the conversion of 3-hydroxybutanal (3-HB) to 1,3-butanediol (1,3-BDO) by using NADPH as a cofactor.
Pssm-ID: 381315 [Multi-domain] Cd Length: 308 Bit Score: 107.73 E-value: 2.24e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 4 RKLRDQVVIATKfttdyKGYDVGKGKSANFcGNHKRsLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEVMDSLHILVQ 83
Cdd:cd19089 72 RPYRDELVISTK-----AGYGMWPGPYGDG-GSRKY-LLASLDQSLKRMGLDYVDIFYHHRYDPDTPLEETMTALADAVR 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 84 QGKVLYLGVSDTPAWVVSAANYYATSHGkTPFSIYQGKWNVLNRDFERDIIPMARHFGMALAPWDVMGGGRFQSK----- 158
Cdd:cd19089 145 SGKALYVGISNYPGAKARRAIALLRELG-VPLIIHQPRYSLLDRWAEDGLLEVLEEAGIGFIAFSPLAQGLLTDKylngi 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 159 KAVEERKKKGeglrTFFGTSEQTDMEVKISEALLKVAEEHGtESVTAIAIAYVRSKAKHVFPLVGGRKIEHLKQNIEAL- 237
Cdd:cd19089 224 PPDSRRAAES----KFLTEEALTPEKLEQLRKLNKIAAKRG-QSLAQLALSWVLRDPRVTSVLIGASSPSQLEDNVAALk 298
|
250
....*....|
gi 766431913 238 SIKLTPEQIK 247
Cdd:cd19089 299 NLDFSEEELA 308
|
|
| AKR_BsYcsN_EcYdhF-like |
cd19092 |
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and ... |
6-245 |
3.96e-27 |
|
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and Escherichia coli YdhF are prototypes of this family. They are uncharacterized aldo/keto reductase family oxidoreductases.
Pssm-ID: 381318 [Multi-domain] Cd Length: 287 Bit Score: 106.49 E-value: 3.96e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 6 LRDQVVIATK---FTTDYKGYdvGKGKSANFCGNHKRSlhvSVRDSLRKLQTDWIDILYVHWWDYMSSIEEVMDSLHILV 82
Cdd:cd19092 66 LREKIEIQTKcgiRLGDDPRP--GRIKHYDTSKEHILA---SVEGSLKRLGTDYLDLLLLHRPDPLMDPEEVAEAFDELV 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 83 QQGKVLYLGVSDTPAWVVSAANyyatSHGKTPFSIYQGKWNVLNRDF----------ERDIIPMArhfgmalapWDVMGG 152
Cdd:cd19092 141 KSGKVRYFGVSNFTPSQIELLQ----SYLDQPLVTNQIELSLLHTEAiddgtldycqLLDITPMA---------WSPLGG 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 153 GRfqskkaveerkkkgeglrtFFGtsEQTDMEVKISEALLKVAEEHGTeSVTAIAIAYVRSKAKHVFPLVGGRKIEHLKQ 232
Cdd:cd19092 208 GR-------------------LFG--GFDERFQRLRAALEELAEEYGV-TIEAIALAWLLRHPARIQPILGTTNPERIRS 265
|
250
....*....|...
gi 766431913 233 NIEALSIKLTPEQ 245
Cdd:cd19092 266 AVKALDIELTREE 278
|
|
| AKR_unchar |
cd19752 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
1-238 |
2.95e-26 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381391 [Multi-domain] Cd Length: 291 Bit Score: 104.34 E-value: 2.95e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 1 MASRKLRDQVVIATKFTTDYKGYDvgkGKSANFCGNHKRSLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEVMDSLHI 80
Cdd:cd19752 60 LKDRGNRDDVVIATKVGAGPRDPD---GGPESPEGLSAETIEQEIDKSLRRLGTDYIDLYYAHVDDRDTPLEETLEAFNE 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 81 LVQQGKVLYLGVSDTPAWVVSAANYYATSHGKTPFSIYQGKWNVL----NRDF------ERDIIPMARHFG----MALAP 146
Cdd:cd19752 137 LVKAGKVRAIGASNFAAWRLERARQIARQQGWAEFSAIQQRHSYLrprpGADFgvqrivTDELLDYASSRPdltlLAYSP 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 147 wdVMGGGRFQSKKAVEErkkkgeglrtffgTSEQTDMEVKISeALLKVAEEHGtesVTAIAIAYV---RSKAKhVFPLVG 223
Cdd:cd19752 217 --LLSGAYTRPDRPLPE-------------QYDGPDSDARLA-VLEEVAGELG---ATPNQVVLAwllHRTPA-IIPLLG 276
|
250
....*....|....*
gi 766431913 224 GRKIEHLKQNIEALS 238
Cdd:cd19752 277 ASTVEQLEENLAALD 291
|
|
| AKR_AKR11A1_11D1 |
cd19083 |
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto ... |
7-253 |
7.75e-26 |
|
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto reductase IolS, also called vegetative protein 147 (VEG147), is a founding member of aldo-keto reductase family 11 member A1 (AKR11A1). It is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose, and methylglyoxal in the presence of NADPH, albeit with poor efficiency in vitro. Bacillus aryabhattai aldo keto reductase is a founding member of aldo-keto reductase family 11 member D1 (AKR11D1).
Pssm-ID: 381309 [Multi-domain] Cd Length: 307 Bit Score: 103.65 E-value: 7.75e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 7 RDQVVIATKFTTDYKGYDVGKGKSANFcgnhkrsLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEVMDSLHILVQQGK 86
Cdd:cd19083 74 RNEVVIATKGAHKFGGDGSVLNNSPEF-------LRSAVEKSLKRLNTDYIDLYYIHFPDGETPKAEAVGALQELKDEGK 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 87 VLYLGVSDTPAWVVSAANyyatshGKTPFSIYQGKWNVLNRDFERDIIPMARHFGMALAPWDVMG----GGRFQSKKAVE 162
Cdd:cd19083 147 IRAIGVSNFSLEQLKEAN------KDGYVDVLQGEYNLLQREAEEDILPYCVENNISFIPYFPLAsgllAGKYTKDTKFP 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 163 E---RKKKGEglrtFFGTSEQTDMEvKISEaLLKVAEEHGTEsVTAIAIAYVRSKakhvfPLV-----GGRKIEHLKQNI 234
Cdd:cd19083 221 DndlRNDKPL----FKGERFSENLD-KVDK-LKSIADEKGVT-VAHLALAWYLTR-----PAIdvvipGAKRAEQVIDNL 288
|
250
....*....|....*....
gi 766431913 235 EALSIKLTPEQIKYLESIV 253
Cdd:cd19083 289 KALDVTLTEEEIAFIDALF 307
|
|
| AKR_unchar |
cd19102 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
2-253 |
1.19e-25 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381328 [Multi-domain] Cd Length: 302 Bit Score: 103.14 E-value: 1.19e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 2 ASRKLRDQVVIATKfttdykGYDVGKGKSANFCGNHKRSLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEVMDSLHIL 81
Cdd:cd19102 61 ALKGLRDRPIVATK------CGLLWDEEGRIRRSLKPASIRAECEASLRRLGVDVIDLYQIHWPDPDEPIEEAWGALAEL 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 82 VQQGKVLYLGVSDTPAWVVSAAnyyATSHgktPFSIYQGKWNVLNRDFERDIIPMARHFGMALAPWDVMGGGRFqSKKAV 161
Cdd:cd19102 135 KEEGKVRAIGVSNFSVDQMKRC---QAIH---PIASLQPPYSLLRRGIEAEILPFCAEHGIGVIVYSPMQSGLL-TGKMT 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 162 EERKKK----GEGLRTFFGTSEQTDMEVKISEALLKVAEEHGTeSVTAIAIAYVRSKAKHVFPLVGGRKIEHLKQNIEAL 237
Cdd:cd19102 208 PERVASlpadDWRRRSPFFQEPNLARNLALVDALRPIAERHGR-TVAQLAIAWVLRRPEVTSAIVGARRPDQIDETVGAA 286
|
250
....*....|....*.
gi 766431913 238 SIKLTPEQIKYLESIV 253
Cdd:cd19102 287 DLRLTPEELAEIEALL 302
|
|
| AKR_AKR7A1-5 |
cd19075 |
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1 ... |
9-238 |
1.93e-25 |
|
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1/AKR7A3/AFAR) from Rattus norvegicus, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR1/AFAR) and aflatoxin B1 aldehyde reductase member 3 (AKR7A3/AFAR2) from Homo sapiens, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR2) from Rattus norvegicus, and aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AKR7A5/AFAR) from Mus musculus, are founding members of aldo-keto reductase family 7 member A1-5 (AKR7A1-5), respectively. AKR7A2 (EC 1.1.1.n11), also called AFB1 aldehyde reductase 1, or AFB1-AR 1, or aldoketoreductase 7, or succinic semialdehyde reductase, or SSA reductase, catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate (GHB). It has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). AKR7A2, AKR7A3 (also called AFB1 aldehyde reductase 2 or AFB1-AR 2), and AKR7A4 (also called AFB1 aldehyde reductase 3, or AFB1-AR 3, or aldoketoreductase 7-like), may be involved in protection of liver against the toxic and carcinogenic effects of aflatoxin B1 (AFB1), a potent hepatocarcinogen. They can reduce the dialdehyde protein-binding form of AFB1 to the non-binding AFB1 dialcohol.
Pssm-ID: 381301 [Multi-domain] Cd Length: 304 Bit Score: 102.63 E-value: 1.93e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 9 QVVIATKFTTDYKGydvgkgksanfcgNHKR-SLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEVMDSLHILVQQGKV 87
Cdd:cd19075 61 GFKIDTKANPGVGG-------------GLSPeNVRKQLETSLKRLKVDKVDVFYLHAPDRSTPLEETLAAIDELYKEGKF 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 88 LYLGVSDTPAWVVSAANYYATSHGKTPFSIYQGKWNVLNRDFERDIIPMARHFGMALAPWDVMGGGrFQSKKAVEERKKK 167
Cdd:cd19075 128 KEFGLSNYSAWEVAEIVEICKENGWVLPTVYQGMYNAITRQVETELFPCLRKLGIRFYAYSPLAGG-FLTGKYKYSEDKA 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 168 GEGLrtFFGTSEQTDM---------EVKISEALLKVAEEHGtESVTAIAIAYVR--S--KAKH---VfpLVGGRKIEHLK 231
Cdd:cd19075 207 GGGR--FDPNNALGKLyrdrywkpsYFEALEKVEEAAEKEG-ISLAEAALRWLYhhSalDGEKgdgV--ILGASSLEQLE 281
|
....*..
gi 766431913 232 QNIEALS 238
Cdd:cd19075 282 ENLAALE 288
|
|
| AKR_AKR6C1_2 |
cd19143 |
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) ... |
7-252 |
2.38e-24 |
|
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa are founding members of aldo-keto reductase family 6 member C1 (AKR6C1) and C2 (AKR6C2), respectively. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381369 [Multi-domain] Cd Length: 319 Bit Score: 99.98 E-value: 2.38e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 7 RDQVVIATKFttdYKGydvGKGKSANFCGNHKRSLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEVMDSLHILVQQGK 86
Cdd:cd19143 74 RSDYVVSTKI---FWG---GGGPPPNDRGLSRKHIVEGTKASLKRLQLDYVDLVFCHRPDPATPIEETVRAMNDLIDQGK 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 87 VLYLGVSDTPAWVVSAANYYATSHGKTPFSIYQGKWNVLNRD-FERDIIPMARHFGMALAPWDVMGGGRFQSK--KAVEE 163
Cdd:cd19143 148 AFYWGTSEWSAQQIEEAHEIADRLGLIPPVMEQPQYNLFHRErVEVEYAPLYEKYGLGTTTWSPLASGLLTGKynNGIPE 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 164 RKKKG----EGLRTFFGTSEQTDMEVkiSEALLKVAEEHGTeSVTAIAIAYVrSKAKHVFPLV-GGRKIEHLKQNIEALS 238
Cdd:cd19143 228 GSRLAlpgyEWLKDRKEELGQEKIEK--VRKLKPIAEELGC-SLAQLAIAWC-LKNPNVSTVItGATKVEQLEENLKALE 303
|
250
....*....|....*.
gi 766431913 239 I--KLTPEQIKYLESI 252
Cdd:cd19143 304 VlpKLTPEVMEKIEAI 319
|
|
| AKR_AKR11B1 |
cd19148 |
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also ... |
7-253 |
7.84e-24 |
|
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381374 [Multi-domain] Cd Length: 302 Bit Score: 98.15 E-value: 7.84e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 7 RDQVVIATKFTTDYKGYDVgkgksanFCGNHKRS-LHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEVMDSLHILVQQG 85
Cdd:cd19148 67 RDRVVIATKVGLEWDEGGE-------VVRNSSPArIRKEVEDSLRRLQTDYIDLYQVHWPDPLVPIEETAEALKELLDEG 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 86 KVLYLGVSdtpawvvsaaNY----YATSHGKTPFSIYQGKWNVLNRDFERDIIPMARHFGMALAPWDVMGGGrFQSKKAV 161
Cdd:cd19148 140 KIRAIGVS----------NFspeqMETFRKVAPLHTVQPPYNLFEREIEKDVLPYARKHNIVTLAYGALCRG-LLSGKMT 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 162 EERKKKGEGLRTF---FgTSEQTDMEVKISEALLKVAEEHGTESVTAIAIAYVRSKAKHVFPLVGGRKIEHLKQNIEALS 238
Cdd:cd19148 209 KDTKFEGDDLRRTdpkF-QEPRFSQYLAAVEELDKLAQERYGKSVIHLAVRWLLDQPGVSIALWGARKPEQLDAVDEVFG 287
|
250
....*....|....*
gi 766431913 239 IKLTPEQIKYLESIV 253
Cdd:cd19148 288 WSLNDEDMKEIDAIL 302
|
|
| tas |
PRK10625 |
putative aldo-keto reductase; Provisional |
1-252 |
1.24e-21 |
|
putative aldo-keto reductase; Provisional
Pssm-ID: 236727 [Multi-domain] Cd Length: 346 Bit Score: 92.99 E-value: 1.24e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 1 MASRKLRDQVVIATKFTTDYKGYDVGKGKSANFcgnHKRSLHVSVRDSLRKLQTDWIDILYVHW------------WDYM 68
Cdd:PRK10625 73 LAKRGSREKLIIASKVSGPSRNNDKGIRPNQAL---DRKNIREALHDSLKRLQTDYLDLYQVHWpqrptncfgklgYSWT 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 69 SS-----IEEVMDSLHILVQQGKVLYLGVSDTPAWVVSAANYYATSHGKTPFSIYQGKWNVLNRDFERDIIPMARHFGMA 143
Cdd:PRK10625 150 DSapavsLLETLDALAEQQRAGKIRYIGVSNETAFGVMRYLHLAEKHDLPRIVTIQNPYSLLNRSFEVGLAEVSQYEGVE 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 144 LAPWDVMGGGRFQSKKAveeRKKKGEGLR-TFFG-----TSEQTDMEVKiseALLKVAEEHGTESvTAIAIAYVRSKAKH 217
Cdd:PRK10625 230 LLAYSCLAFGTLTGKYL---NGAKPAGARnTLFSrftrySGEQTQKAVA---AYVDIAKRHGLDP-AQMALAFVRRQPFV 302
|
250 260 270
....*....|....*....|....*....|....*
gi 766431913 218 VFPLVGGRKIEHLKQNIEALSIKLTPEQIKYLESI 252
Cdd:PRK10625 303 ASTLLGATTMEQLKTNIESLHLTLSEEVLAEIEAV 337
|
|
| AKR_AKR14A2 |
cd19151 |
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is ... |
4-238 |
1.49e-19 |
|
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2).
Pssm-ID: 381377 [Multi-domain] Cd Length: 309 Bit Score: 86.69 E-value: 1.49e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 4 RKLRDQVVIATKfttdyKGYDVGKGKSANFcgNHKRSLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEVMDSLHILVQ 83
Cdd:cd19151 73 KPYRDELIISTK-----AGYTMWPGPYGDW--GSKKYLIASLDQSLKRMGLDYVDIFYHHRPDPETPLEETMGALDQIVR 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 84 QGKVLYLGVSDTPAWVVSAANYYATSHGkTPFSIYQGKWNVLNRDFERDIIPMARHFGMALAPWDVMGGGRFQSK--KAV 161
Cdd:cd19151 146 QGKALYVGISNYPPEEAREAAAILKDLG-TPCLIHQPKYSMFNRWVEEGLLDVLEEEGIGCIAFSPLAQGLLTDRylNGI 224
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 766431913 162 EERKKKGEGlRTFFGTSEQTDMEVKISEALLKVAEEHGtESVTAIAIAYVRSKAKHVFPLVGGRKIEHLKQNIEALS 238
Cdd:cd19151 225 PEDSRAAKG-SSFLKPEQITEEKLAKVRRLNEIAQARG-QKLAQMALAWVLRNKRVTSVLIGASKPSQIEDAVGALD 299
|
|
| AKR_AKR13A1 |
cd19144 |
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC ... |
6-253 |
2.96e-19 |
|
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor.
Pssm-ID: 381370 [Multi-domain] Cd Length: 323 Bit Score: 85.96 E-value: 2.96e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 6 LRDQVVIATKFttdykGYDVGKGKSANFCGNHKRSLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEVMDSLHILVQQG 85
Cdd:cd19144 74 KREKIFLATKF-----GIEKNVETGEYSVDGSPEYVKKACETSLKRLGVDYIDLYYQHRVDGKTPIEKTVAAMAELVQEG 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 86 KVLYLGVSDTPAWVVSAAnyyatsHGKTPFSIYQGKWNVLNRDFER---DIIPMARHFGMALAPWDVMG----GGRFQSK 158
Cdd:cd19144 149 KIKHIGLSECSAETLRRA------HAVHPIAAVQIEYSPFSLDIERpeiGVLDTCRELGVAIVAYSPLGrgflTGAIRSP 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 159 KAVEERKKKGEGLRTffgTSEQTDMEVKISEALLKVAEEHGtesVTA--IAIAYVRSKAKHVFPLVGGRKIEHLKQNIEA 236
Cdd:cd19144 223 DDFEEGDFRRMAPRF---QAENFPKNLELVDKIKAIAKKKN---VTAgqLTLAWLLAQGDDIIPIPGTTKLKRLEENLGA 296
|
250
....*....|....*..
gi 766431913 237 LSIKLTPEQIKYLESIV 253
Cdd:cd19144 297 LKVKLTEEEEKEIREIA 313
|
|
| AKR_AKR13B1 |
cd19088 |
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde ... |
7-242 |
1.12e-18 |
|
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.
Pssm-ID: 381314 [Multi-domain] Cd Length: 256 Bit Score: 83.04 E-value: 1.12e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 7 RDQVVIATKfttdykgydVG----KGKSANFCGnHKRSLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEVMDSLHILV 82
Cdd:cd19088 64 PDDVVIATK---------GGlvrtGPGWWGPDG-SPEYLRQAVEASLRRLGLDRIDLYQLHRIDPKVPFEEQLGALAELQ 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 83 QQGKVLYLGVSDtpawvVSAANyYATSHGKTPFSIYQGKWNVLNRDFErDIIPMARHFGMALAPWDVMGGGrfqskkave 162
Cdd:cd19088 134 DEGLIRHIGLSN-----VTVAQ-IEEARAIVRIVSVQNRYNLANRDDE-GVLDYCEAAGIAFIPWFPLGGG--------- 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 163 erkkkgeGLRtffgtseqtdmevKISEALLKVAEEHGTeSVTAIAIAYVRSKAKHVFPLVGGRKIEHLKQNIEALSIKLT 242
Cdd:cd19088 198 -------DLA-------------QPGGLLAEVAARLGA-TPAQVALAWLLARSPVMLPIPGTSSVEHLEENLAAAGLRLS 256
|
|
| AKR_PA4992-like |
cd19095 |
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the ... |
3-236 |
7.21e-18 |
|
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the prototype of this family. It is a putative aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381321 [Multi-domain] Cd Length: 253 Bit Score: 80.74 E-value: 7.21e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 3 SRKLRDQVVIATKFTTDYKGYDVGKGKSANfcgnhkrslHV--SVRDSLRKLQTDWIDILYVH----WWDYmssiEEVMD 76
Cdd:cd19095 55 AGLRRDDLFIATKVGTHGEGGRDRKDFSPA---------AIraSIERSLRRLGTDYIDLLQLHgpsdDELT----GEVLE 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 77 SLHILVQQGKVLYLGVS-DTPawvvsAANYYATSHgktPFSIYQGKWNVLNRDfERDIIPMARHFGMAlapwdVMGGGRF 155
Cdd:cd19095 122 TLEDLKAAGKVRYIGVSgDGE-----ELEAAIASG---VFDVVQLPYNVLDRE-EEELLPLAAEAGLG-----VIVNRPL 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 156 qskkaveerkkkGEGLRTFFGTSEQTDMEVkisEALLKVAEEHGTESVTAIAIAYV-RSKAKHVfPLVGGRKIEHLKQNI 234
Cdd:cd19095 188 ------------ANGRLRRRVRRRPLYADY---ARRPEFAAEIGGATWAQAALRFVlSHPGVSS-AIVGTTNPEHLEENL 251
|
..
gi 766431913 235 EA 236
Cdd:cd19095 252 AA 253
|
|
| AKR_AKR15A-like |
cd19090 |
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes ... |
7-244 |
9.69e-18 |
|
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH) and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. The family also includes L-galactose dehydrogenase (L-galDH) and D-arabinose 1-dehydrogenase (ARA2). L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381316 [Multi-domain] Cd Length: 278 Bit Score: 81.06 E-value: 9.69e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 7 RDQVVIATKfttdykgydVGKGKSANFCGNHKRsLHVSVRDSLRKLQTDWIDILYVH------WWDYMsSIEEVMDSLHI 80
Cdd:cd19090 59 REPLVLSTK---------VGRLPEDTADYSADR-VRRSVEESLERLGRDRIDLLMIHdpervpWVDIL-APGGALEALLE 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 81 LVQQGKVLYLGVSDTPAwvvsAANYYATSHGKTPFSIYQGKWNVLNRDFERDIIPMARHFGMAlapwdVMGGGRFQ---- 156
Cdd:cd19090 128 LKEEGLIKHIGLGGGPP----DLLRRAIETGDFDVVLTANRYTLLDQSAADELLPAAARHGVG-----VINASPLGmgll 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 157 SKKAVEERKKKGEGLrtffgtseqTDMEVKISEALLKVAEEHGtESVTAIAIAYV-RSKAKHVFpLVGGRKIEHLKQNIE 235
Cdd:cd19090 199 AGRPPERVRYTYRWL---------SPELLDRAKRLYELCDEHG-VPLPALALRFLlRDPRISTV-LVGASSPEELEQNVA 267
|
....*....
gi 766431913 236 ALSIKLTPE 244
Cdd:cd19090 268 AAEGPLPEE 276
|
|
| AKR_AKR3F1 |
cd19137 |
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding ... |
41-250 |
5.97e-17 |
|
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381363 [Multi-domain] Cd Length: 260 Bit Score: 78.38 E-value: 5.97e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 41 LHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEVMDSLHILVQQGKVLYLGVSDTPAWVVSAANYYAtshgKTPFSIYQG 120
Cdd:cd19137 86 LLRSLQNSLRRLDTDYIDLYLIHWPNPNIPLEETLSAMAEGVRQGLIRYIGVSNFNRRLLEEAISKS----QTPIVCNQV 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 121 KWNVLNRDFERD-IIPMARHFG---MALAPWDvmgggrfqskkaveerkkkgeglRTFfgtseqtdmeVKISEALLKVAE 196
Cdd:cd19137 162 KYNLEDRDPERDgLLEYCQKNGitvVAYSPLR-----------------------RGL----------EKTNRTLEEIAK 208
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 766431913 197 EHGtESVTAIAIAYVRSKAKHV-FPLVGgrKIEHLKQNIEALSIKLTPEQIKYLE 250
Cdd:cd19137 209 NYG-KTIAQIALAWLIQKPNVVaIPKAG--RVEHLKENLKATEIKLSEEEMKLLD 260
|
|
| AKR_AKR11C1 |
cd19086 |
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase ... |
4-144 |
8.84e-17 |
|
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase YqkF is a founding member of aldo-keto reductase family 11 member C1 (AKR11C1). It may function as oxidoreductase. This family also includes Bacillus halodurans AKR11C1, an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase.
Pssm-ID: 381312 [Multi-domain] Cd Length: 238 Bit Score: 77.52 E-value: 8.84e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 4 RKLRDQVVIATKFttdykGYDVGKGKSA--NFCGNHKRSlhvSVRDSLRKLQTDWIDILYVH-WWDYMSSIEEVMDSLHI 80
Cdd:cd19086 61 KGRRDKVVIATKF-----GNRFDGGPERpqDFSPEYIRE---AVEASLKRLGTDYIDLYQLHnPPDEVLDNDELFEALEK 132
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 766431913 81 LVQQGKVLYLGVSDTPAWVVSAANyyATSHGKTPFSIYqgkwNVLNRDFERDIIPMARHFGMAL 144
Cdd:cd19086 133 LKQEGKIRAYGVSVGDPEEALAAL--RRGGIDVVQVIY----NLLDQRPEEELFPLAEEHGVGV 190
|
|
| AKR_AKR14A1 |
cd19150 |
Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar ... |
7-247 |
9.41e-17 |
|
Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar proteins; Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo.
Pssm-ID: 381376 [Multi-domain] Cd Length: 309 Bit Score: 78.65 E-value: 9.41e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 7 RDQVVIATKfttdyKGYDVGKGKSANfcGNHKRSLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEVMDSLHILVQQGK 86
Cdd:cd19150 76 RDELIISTK-----AGYDMWPGPYGE--WGSRKYLLASLDQSLKRMGLDYVDIFYSHRFDPDTPLEETMGALDHAVRSGK 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 87 VLYLGVSD-TPAWVVSAANYYATShgKTPFSIYQGKWNVLNRDFERD-IIPMARHFGMALAPWDVMGGGRFQSK--KAVE 162
Cdd:cd19150 149 ALYVGISSySPERTREAAAILREL--GTPLLIHQPSYNMLNRWVEESgLLDTLQELGVGCIAFTPLAQGLLTDKylNGIP 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 163 E--RKKKGEGLRTFFGTsEQTDMEVKiseALLKVAEEHGtESVTAIAIAYVRSKAKHVFPLVGGRKIEHLKQNIEAL-SI 239
Cdd:cd19150 227 EgsRASKERSLSPKMLT-EANLNSIR---ALNEIAQKRG-QSLAQMALAWVLRDGRVTSALIGASRPEQLEENVGALdNL 301
|
....*...
gi 766431913 240 KLTPEQIK 247
Cdd:cd19150 302 TFSADELA 309
|
|
| PRK09912 |
PRK09912 |
L-glyceraldehyde 3-phosphate reductase; Provisional |
7-253 |
2.01e-16 |
|
L-glyceraldehyde 3-phosphate reductase; Provisional
Pssm-ID: 182140 [Multi-domain] Cd Length: 346 Bit Score: 78.11 E-value: 2.01e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 7 RDQVVIATKfttdyKGYDVGKGKSANfcGNHKRSLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEVMDSLHILVQQGK 86
Cdd:PRK09912 89 RDELIISTK-----AGYDMWPGPYGS--GGSRKYLLASLDQSLKRMGLEYVDIFYSHRVDENTPMEETASALAHAVQSGK 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 87 VLYLGVSD-TPAWVVSAANYYatSHGKTPFSIYQGKWNVLNRDFERD-IIPMARHFGMALAPWDVMGGGRFQSK--KAVE 162
Cdd:PRK09912 162 ALYVGISSySPERTQKMVELL--REWKIPLLIHQPSYNLLNRWVDKSgLLDTLQNNGVGCIAFTPLAQGLLTGKylNGIP 239
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 163 E---RKKKGEGLRtffGTSEQTDMEVKISEALL--KVAEEHGtESVTAIAIAYVRSKAKHVFPLVGGRKIEHLKQNIEAL 237
Cdd:PRK09912 240 QdsrMHREGNKVR---GLTPKMLTEANLNSLRLlnEMAQQRG-QSMAQMALSWLLKDERVTSVLIGASRAEQLEENVQAL 315
|
250
....*....|....*..
gi 766431913 238 S-IKLTPEQIKYLESIV 253
Cdd:PRK09912 316 NnLTFSTEELAQIDQHI 332
|
|
| AKR_YeaE |
cd19138 |
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this ... |
48-250 |
4.30e-16 |
|
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this family. It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381364 [Multi-domain] Cd Length: 266 Bit Score: 76.13 E-value: 4.30e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 48 SLRKLQTDWIDILYVHWwdyMSSI--EEVMDSLHILVQQGKVLYLGVS--DTP----AWVVSAANYYATShgktpfsiyQ 119
Cdd:cd19138 95 SLRRLGTDYLDLYLLHW---RGGVplAETVAAMEELKKEGKIRAWGVSnfDTDdmeeLWAVPGGGNCAAN---------Q 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 120 GKWNVLNRDFERDIIPMARHFGMALAPWDVMGGGRFQSKKAVEerkkkgeglrtffgtseqtdmevkiSEALLKVAEEHG 199
Cdd:cd19138 163 VLYNLGSRGIEYDLLPWCREHGVPVMAYSPLAQGGLLRRGLLE-------------------------NPTLKEIAARHG 217
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 766431913 200 TeSVTAIAIAYV-RSKAKHVFPLVGgrKIEHLKQNIEALSIKLTPEQIKYLE 250
Cdd:cd19138 218 A-TPAQVALAWVlRDGNVIAIPKSG--SPEHARENAAAADLELTEEDLAELD 266
|
|
| AKR_AKR3F2_3 |
cd19073 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti ... |
2-247 |
7.60e-15 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti isatin reductase and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381299 [Multi-domain] Cd Length: 243 Bit Score: 72.30 E-value: 7.60e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 2 ASRKLRDQVVIATKFTTDYKGYDvgkgksanfcgnhkrSLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEVMDSLHIL 81
Cdd:cd19073 49 ESGVPREDLFITTKVWRDHLRPE---------------DLKKSVDRSLEKLGTDYVDLLLIHWPNPTVPLEETLGALKEL 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 82 VQQGKVLYLGVSD-TPAWVVSAANYYAT--SHGKTPFSIYQGKWNVLNRDFERDIIPMARhfgMALApwdvmgggrfqsk 158
Cdd:cd19073 114 KEAGKVKSIGVSNfTIELLEEALDISPLpiAVNQVEFHPFLYQAELLEYCRENDIVITAY---SPLA------------- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 159 kaveerkkKGEGLRtffgtseqtdmevkiSEALLKVAEEHGTESVTaIAIAYVRSKAKHVFPlvGGRKIEHLKQNIEALS 238
Cdd:cd19073 178 --------RGEVLR---------------DPVIQEIAEKYDKTPAQ-VALRWLVQKGIVVIP--KASSEDHLKENLAIFD 231
|
....*....
gi 766431913 239 IKLTPEQIK 247
Cdd:cd19073 232 WELTSEDVA 240
|
|
| AKR_unchar |
cd19105 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
7-237 |
9.71e-15 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381331 [Multi-domain] Cd Length: 250 Bit Score: 72.23 E-value: 9.71e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 7 RDQVVIATKFTTDYKGYDvgkgksanfcgnhKRSLHVSVRDSLRKLQTDWIDILYVHWWDYMSSI---EEVMDSLHILVQ 83
Cdd:cd19105 66 RDKVFLATKASPRLDKKD-------------KAELLKSVEESLKRLQTDYIDIYQLHGVDTPEERllnEELLEALEKLKK 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 84 QGKVLYLGVS--DTPAWVVSAAnyyatSHGKtPFSIYQGKWNVLNRDFERD-IIPMARHFGMALAPWDVMGGGRFQSKKA 160
Cdd:cd19105 133 EGKVRFIGFSthDNMAEVLQAA-----IESG-WFDVIMVAYNFLNQPAELEeALAAAAEKGIGVVAMKTLAGGYLQPALL 206
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 766431913 161 VEERKKKGEglrtffgtseqtdmevkISEALLKVAEEHgtESVTAIaiayvrskakhvfpLVGGRKIEHLKQNIEAL 237
Cdd:cd19105 207 SVLKAKGFS-----------------LPQAALKWVLSN--PRVDTV--------------VPGMRNFAELEENLAAA 250
|
|
| AKR_unchar |
cd19101 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
1-253 |
2.37e-14 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381327 [Multi-domain] Cd Length: 304 Bit Score: 71.86 E-value: 2.37e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 1 MASRKLRDQVVIATKFTTDYKGYDVGKGksanfcgnhkrslHV--SVRDSLRKLQTDWIDILYVHWWDY-MSSIEEVMDS 77
Cdd:cd19101 61 RRERDAADDVQIHTKWVPDPGELTMTRA-------------YVeaAIDRSLKRLGVDRLDLVQFHWWDYsDPGYLDAAKH 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 78 LHILVQQGKVLYLGVS--DTPAWvvsaanYYATSHGKTPFSiYQGKWNVLNRDFERDIIPMARHFGMALAPWDVMGGGrF 155
Cdd:cd19101 128 LAELQEEGKIRHLGLTnfDTERL------REILDAGVPIVS-NQVQYSLLDRRPENGMAALCEDHGIKLLAYGTLAGG-L 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 156 QSKKAVEERKKKGEGLRTffgTSEQTDMEV-----------KISEALLKVAEEHGTeSVTAIAIAYVRSKAKHVFPLVGG 224
Cdd:cd19101 200 LSEKYLGVPEPTGPALET---RSLQKYKLMidewggwdlfqELLRTLKAIADKHGV-SIANVAVRWVLDQPGVAGVIVGA 275
|
250 260
....*....|....*....|....*....
gi 766431913 225 RKIEHLKQNIEALSIKLTPEQIKYLESIV 253
Cdd:cd19101 276 RNSEHIDDNVRAFSFRLDDEDRAAIDAVL 304
|
|
| AKR_unchar |
cd19103 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
7-251 |
3.97e-14 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381329 [Multi-domain] Cd Length: 299 Bit Score: 71.21 E-value: 3.97e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 7 RDQVVIATKFTTDykgydvGKGKSANfcgnhkrslhvSVRD----SLRKLQTDWIDILYVHwwdYMSSIEEVMDSLHILV 82
Cdd:cd19103 73 REDYIISTKFTPQ------IAGQSAD-----------PVADmlegSLARLGTDYIDIYWIH---NPADVERWTPELIPLL 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 83 QQGKVLYLGVSDTPAWVVSAANYYAtshGKTPFSIY--QGKWNVLNRDFERD-IIPMARHFGMALAPWDVMGGGRFQSKK 159
Cdd:cd19103 133 KSGKVKHVGVSNHNLAEIKRANEIL---AKAGVSLSavQNHYSLLYRSSEEAgILDYCKENGITFFAYMVLEQGALSGKY 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 160 AVEERKKKGEGLRTFFGTSEQtDMEvKISEALLKVAEEHGTeSVTAIAIAYVRskAKHVFPLVGGRKIEHLKQNIEALSI 239
Cdd:cd19103 210 DTKHPLPEGSGRAETYNPLLP-QLE-ELTAVMAEIGAKHGA-SIAQVAIAWAI--AKGTTPIIGVTKPHHVEDAARAASI 284
|
250
....*....|..
gi 766431913 240 KLTPEQIKYLES 251
Cdd:cd19103 285 TLTDDEIKELEQ 296
|
|
| COG1453 |
COG1453 |
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only]; |
4-252 |
1.11e-13 |
|
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];
Pssm-ID: 441062 [Multi-domain] Cd Length: 365 Bit Score: 70.23 E-value: 1.11e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 4 RKLRDQVVIATKFTTDYKGYDvgkgksanfcgNHKRSLHvsvrDSLRKLQTDWIDILYVHWWDYMSSIEEVMDSLHIL-- 81
Cdd:COG1453 64 KGPRDKVILATKLPPWVRDPE-----------DMRKDLE----ESLKRLQTDYIDLYLIHGLNTEEDLEKVLKPGGALea 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 82 ----VQQGKVLYLGVS--DTPAWVVSAANYYatshgktPFSIYQGKWNVLNRDF--ERDIIPMARHFGMALApwdVM--- 150
Cdd:COG1453 129 lekaKAEGKIRHIGFSthGSLEVIKEAIDTG-------DFDFVQLQYNYLDQDNqaGEEALEAAAEKGIGVI---IMkpl 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 151 GGGRFqskkaveerkkkgeglrtffgtseqtdmeVKISEALLKVAEEhgTESVTAIAIAYVRSKAKHVFPLVGGRKIEHL 230
Cdd:COG1453 199 KGGRL-----------------------------ANPPEKLVELLCP--PLSPAEWALRFLLSHPEVTTVLSGMSTPEQL 247
|
250 260
....*....|....*....|....
gi 766431913 231 KQNIEALS--IKLTPEQIKYLESI 252
Cdd:COG1453 248 DENLKTADnlEPLTEEELAILERL 271
|
|
| ARA1 |
COG0656 |
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ... |
7-252 |
2.52e-13 |
|
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 440421 [Multi-domain] Cd Length: 259 Bit Score: 68.16 E-value: 2.52e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 7 RDQVVIATKFTTDYKGYDvgkgksanfcgnhkrSLHVSVRDSLRKLQTDWIDILYVHW---WDYMSSIEEvMDSlhiLVQ 83
Cdd:COG0656 58 REELFVTTKVWNDNHGYD---------------DTLAAFEESLERLGLDYLDLYLIHWpgpGPYVETWRA-LEE---LYE 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 84 QGKVLYLGVSD-TPA---WVVSAAnyyatshGKTP------FSIYQGKWNVLNRDFERDIIPMArhfgmalapWDVMGGG 153
Cdd:COG0656 119 EGLIRAIGVSNfDPEhleELLAET-------GVKPavnqveLHPYLQQRELLAFCREHGIVVEA---------YSPLGRG 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 154 RfqskkaveerkkkgeglrtffgtseqtDMEvkiSEALLKVAEEHGTeSVTAIAIAYVRskAKHVFPLVGGRKIEHLKQN 233
Cdd:COG0656 183 K---------------------------LLD---DPVLAEIAEKHGK-TPAQVVLRWHL--QRGVVVIPKSVTPERIREN 229
|
250
....*....|....*....
gi 766431913 234 IEALSIKLTPEQIKYLESI 252
Cdd:COG0656 230 LDAFDFELSDEDMAAIDAL 248
|
|
| AKR_AKR8A1-2 |
cd19077 |
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding ... |
6-250 |
6.70e-13 |
|
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding members of aldo-keto reductase family 8 member A1-2 (AKR8A1-2), respectively. PLR (EC 1.1.1.65), also called PL reductase (PL-red), catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+).
Pssm-ID: 381303 [Multi-domain] Cd Length: 302 Bit Score: 67.65 E-value: 6.70e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 6 LRDQVVIATKFTTDYKGYDVGKGKSAnfcgnhkrsLHVSVRDSLRKL-QTDWIDILYVHWWDYMSSIEEVMDSLHILVQQ 84
Cdd:cd19077 70 YADKVVLSVKGGLDPDTLRPDGSPEA---------VRKSIENILRALgGTKKIDIFEPARVDPNVPIEETIKALKELVKE 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 85 GKVLYLGVSDTPAWVVSAAnyyatsHGKTPFSIYQGKWNVLNRD-FERDIIPMARHFGMALAPWDVMGGGRF--QSKKAV 161
Cdd:cd19077 141 GKIRGIGLSEVSAETIRRA------HAVHPIAAVEVEYSLFSREiEENGVLETCAELGIPIIAYSPLGRGLLtgRIKSLA 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 162 EERKKKGEGLRTFFgTSEQTDMEVKISEALLKVAEEHGTeSVTAIAIAYVRSKAK-HVFPLVGGRKIEHLKQNIEALSIK 240
Cdd:cd19077 215 DIPEGDFRRHLDRF-NGENFEKNLKLVDALQELAEKKGC-TPAQLALAWILAQSGpKIIPIPGSTTLERVEENLKAANVE 292
|
250
....*....|
gi 766431913 241 LTPEQIKYLE 250
Cdd:cd19077 293 LTDEELKEIN 302
|
|
| AKR_AKR1-5-like |
cd19071 |
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ... |
7-250 |
3.43e-12 |
|
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.
Pssm-ID: 381297 [Multi-domain] Cd Length: 251 Bit Score: 64.81 E-value: 3.43e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 7 RDQVVIATKFTTDYKGYDvgkgksanfcgnhkrSLHVSVRDSLRKLQTDWIDILYVHW---WDYMSSIEEVMDS---LHI 80
Cdd:cd19071 54 REELFITTKLWPTDHGYE---------------RVREALEESLKDLGLDYLDLYLIHWpvpGKEGGSKEARLETwraLEE 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 81 LVQQGKVLYLGVSdtpawvvsaaNYYAT------SHGKTPFSIYQGKWNVLN-----RDF--ERDIIPMArhfgmalapW 147
Cdd:cd19071 119 LVDEGLVRSIGVS----------NFNVEhleellAAARIKPAVNQIELHPYLqqkelVEFckEHGIVVQA---------Y 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 148 DVMGGGRFQSKKaveerkkkgeglrtffgtseqtdmevkiSEALLKVAEEHGTeSVTAIAIAYVRSkaKHVFPLVGGRKI 227
Cdd:cd19071 180 SPLGRGRRPLLD----------------------------DPVLKEIAKKYGK-TPAQVLLRWALQ--RGVVVIPKSSNP 228
|
250 260
....*....|....*....|...
gi 766431913 228 EHLKQNIEALSIKLTPEQIKYLE 250
Cdd:cd19071 229 ERIKENLDVFDFELSEEDMAAID 251
|
|
| AKR_AKR3F3 |
cd19140 |
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin ... |
7-252 |
5.29e-11 |
|
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381366 [Multi-domain] Cd Length: 253 Bit Score: 61.51 E-value: 5.29e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 7 RDQVVIATK-FTTDYKGYDVGKgksanfcgnhkrslhvSVRDSLRKLQTDWIDILYVHWWDYMSSIEEVMDSLHILVQQG 85
Cdd:cd19140 61 RDELFLTTKvWPDNYSPDDFLA----------------SVEESLRKLRTDYVDLLLLHWPNKDVPLAETLGALNEAQEAG 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 86 KVLYLGVSDTPAWVVSAanyyATSHGKTPFSIYQGKWNVLNRdfERDIIPMARHFGMALAPWDVMGGGrfqskkaveerk 165
Cdd:cd19140 125 LARHIGVSNFTVALLRE----AVELSEAPLFTNQVEYHPYLD--QRKLLDAAREHGIALTAYSPLARG------------ 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 166 kkgeglrtffgtseqtdmEVKISEALLKVAEEHGtESVTAIAIAYVRSKAKhVFPLVGGRKIEHLKQNIEALSIKLTPEQ 245
Cdd:cd19140 187 ------------------EVLKDPVLQEIGRKHG-KTPAQVALRWLLQQEG-VAAIPKATNPERLEENLDIFDFTLSDEE 246
|
....*..
gi 766431913 246 IKYLESI 252
Cdd:cd19140 247 MARIAAL 253
|
|
| AKR_unchar |
cd19100 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
7-162 |
8.08e-11 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381326 [Multi-domain] Cd Length: 238 Bit Score: 60.57 E-value: 8.08e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 7 RDQVVIATKF-TTDYKGydvgkgksAnfcgnhKRSLHvsvrDSLRKLQTDWIDILYVH------WWDYMSSIEEVMDSLH 79
Cdd:cd19100 65 RDKVFLATKTgARDYEG--------A------KRDLE----RSLKRLGTDYIDLYQLHavdteeDLDQVFGPGGALEALL 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 80 ILVQQGKVLYLGVSD-TPAWVVSAANYYatshgktPFSIYQGKWNVL---NRDFERDIIPMARHFGMALAPWDVMGGGRF 155
Cdd:cd19100 127 EAKEEGKIRFIGISGhSPEVLLRALETG-------EFDVVLFPINPAgdhIDSFREELLPLAREKGVGVIAMKVLAGGRL 199
|
....*..
gi 766431913 156 QSKKAVE 162
Cdd:cd19100 200 LSGDPLD 206
|
|
| AKR_AKR6B1 |
cd19142 |
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding ... |
7-93 |
1.43e-10 |
|
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding member of aldo-keto reductase family 6 member B1 (AKR6B1). Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase.
Pssm-ID: 381368 [Multi-domain] Cd Length: 325 Bit Score: 60.94 E-value: 1.43e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 7 RDQVVIATKFTTDYKGYDvgkgksanfCGNHKRSLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEVMDSLHILVQQGK 86
Cdd:cd19142 74 RSSYIVSTKIYWSYGSEE---------RGLSRKHIIESVRASLRRLQLDYIDIVIIHKADPMCPMEEVVRAMSYLIDNGL 144
|
....*..
gi 766431913 87 VLYLGVS 93
Cdd:cd19142 145 IMYWGTS 151
|
|
| AKR_unchar |
cd19097 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
8-240 |
3.07e-10 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381323 [Multi-domain] Cd Length: 267 Bit Score: 59.46 E-value: 3.07e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 8 DQVVIATKFTtdykgydvgkgKSANFCGNHKRSLHVSVRDSLRKLQTDWIDILYVHWWDYMSSI-EEVMDSLHILVQQGK 86
Cdd:cd19097 64 DKFKIITKLP-----------PLKEDKKEDEAAIEASVEASLKRLKVDSLDGLLLHNPDDLLKHgGKLVEALLELKKEGL 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 87 VLYLGVS-DTPAWVVSAANYYatshgktPFSIYQGKWNVLNRDFER-DIIPMARhfgmalapwdvmgggrfQSKKAV--- 161
Cdd:cd19097 133 IRKIGVSvYSPEELEKALESF-------KIDIIQLPFNILDQRFLKsGLLAKLK-----------------KKGIEIhar 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 162 ------------EERKKKGEGLRTFFgtseqtdmevkisEALLKVAEEHGTeSVTAIAIAYVRSKaKHVFP-LVGGRKIE 228
Cdd:cd19097 189 svflqglllmepDKLPAKFAPAKPLL-------------KKLHELAKKLGL-SPLELALGFVLSL-PEIDKiVVGVDSLE 253
|
250
....*....|..
gi 766431913 229 HLKQNIEALSIK 240
Cdd:cd19097 254 QLKEIIAAFKKP 265
|
|
| AKR_KCAB3B_AKR6A9-like |
cd19160 |
voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo ... |
7-253 |
3.36e-10 |
|
voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo sapiens, Rattus norvegicus, and Mus musculus, are founding members of aldo-keto reductase family 6 member A9 (AKR6A9), A12 (AKR6A12), A14 (AKR6A14), respectively. KCAB3B, also called Shaker channel b-subunit 3 (Kvb3), K(+) channel subunit beta-3, or Kv-beta-3, is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. It alters the functional properties of Kv1.5.
Pssm-ID: 381386 [Multi-domain] Cd Length: 325 Bit Score: 59.61 E-value: 3.36e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 7 RDQVVIATKFttdYKGydvgkGKSANFCGNHKRSLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEVMDSLHILVQQGK 86
Cdd:cd19160 76 RSSYVVTTKI---YWG-----GQAETERGLSRKHIIEGLRGSLDRLQLEYVDIVFANRSDPNSPMEEIVRAMTYVINQGM 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 87 VLYLGVSDTPAWVVSAANYYATSHGKTPFSIYQGKWNVLNRDFERDIIPMARH-FGMALAPWDVMGGGRFQSK--KAVEE 163
Cdd:cd19160 148 AMYWGTSRWSAMEIMEAYSVARQFNLIPPVCEQAEYHLFQREKVEMQLPELYHkIGVGSVTWSPLACGLITGKydGRVPD 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 164 RKK---KG-EGLRTFFGTSEQTDMEVKISEaLLKVAEEHGTeSVTAIAIAY-VRSKAKHVFpLVGGRKIEHLKQNIEALS 238
Cdd:cd19160 228 TCRaavKGyQWLKEKVQSEEGKKQQAKVKE-LHPIADRLGC-TVAQLAIAWcLRSEGVSSV-LLGVSSAEQLIENLGSIQ 304
|
250
....*....|....*..
gi 766431913 239 I--KLTPEQIKYLESIV 253
Cdd:cd19160 305 VlsQLTPQTVMEIDALL 321
|
|
| AKR_galDH |
cd19163 |
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called ... |
7-93 |
1.03e-09 |
|
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+).
Pssm-ID: 381389 [Multi-domain] Cd Length: 293 Bit Score: 57.95 E-value: 1.03e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 7 RDQVVIATKFttdykG-YDVGKGKSANFcgNHKRSLHvSVRDSLRKLQTDWIDILYVHWWDYMSSIEEVMD----SLHIL 81
Cdd:cd19163 74 RDSYYLATKV-----GrYGLDPDKMFDF--SAERITK-SVEESLKRLGLDYIDIIQVHDIEFAPSLDQILNetlpALQKL 145
|
90
....*....|..
gi 766431913 82 VQQGKVLYLGVS 93
Cdd:cd19163 146 KEEGKVRFIGIT 157
|
|
| PRK10376 |
PRK10376 |
putative oxidoreductase; Provisional |
7-252 |
1.71e-08 |
|
putative oxidoreductase; Provisional
Pssm-ID: 236676 [Multi-domain] Cd Length: 290 Bit Score: 54.59 E-value: 1.71e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 7 RDQVVIATKfttdykgydVGKGKSANFCGNHKRS---LHVSVRDSLRKLQTDWIDILYVH-WWDYMS----SIEEVMDSL 78
Cdd:PRK10376 80 PDDLTIVTK---------VGARRGEDGSWLPAFSpaeLRRAVHDNLRNLGLDVLDVVNLRlMGDGHGpaegSIEEPLTVL 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 79 HILVQQGKVLYLGVSD-TPAWVVSAanyyatsHGKTPFSIYQGKWNVLNRDFERDIIPMARHfGMALAPWDVMGGgrFqs 157
Cdd:PRK10376 151 AELQRQGLVRHIGLSNvTPTQVAEA-------RKIAEIVCVQNHYNLAHRADDALIDALARD-GIAYVPFFPLGG--F-- 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 158 kkaveerkkkgeglrtffgTSEQtdmevkiSEALLKVAEEHGTeSVTAIAIAYVRSKAKHVFPLVGGRKIEHLKQNIEAL 237
Cdd:PRK10376 219 -------------------TPLQ-------SSTLSDVAASLGA-TPMQVALAWLLQRSPNILLIPGTSSVAHLRENLAAA 271
|
250
....*....|....*
gi 766431913 238 SIKLTPEQIKYLESI 252
Cdd:PRK10376 272 ELVLSEEVLAELDGI 286
|
|
| Aldo_ket_red_shaker |
cd19141 |
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family ... |
7-243 |
2.39e-08 |
|
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381367 [Multi-domain] Cd Length: 310 Bit Score: 53.99 E-value: 2.39e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 7 RDQVVIATKFttdYKGydvgkGKSANFCGNHKRSLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEVMDSLHILVQQGK 86
Cdd:cd19141 73 RSSYVITTKI---FWG-----GKAETERGLSRKHIIEGLKASLERLQLEYVDIVFANRPDPNTPMEEIVRAFTHVINQGM 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 87 VLYLGVSDTPAWVVSAANYYATSHGKTPFSIYQGKWNVLNRDFERDIIPMARH-FGMALAPWDVMGGGRFQSK--KAVEE 163
Cdd:cd19141 145 AMYWGTSRWSAMEIMEAYSVARQFNLIPPIVEQAEYHLFQREKVEMQLPELFHkIGVGAMTWSPLACGILSGKydDGVPE 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 164 RKK---KGEG-LRTFFGTSEQTDMEVKISEaLLKVAEEHGTeSVTAIAIAY-VRSKAKHVFpLVGGRKIEHLKQNIEALS 238
Cdd:cd19141 225 YSRaslKGYQwLKEKILSEEGRRQQAKLKE-LQIIADRLGC-TLPQLAIAWcLKNEGVSSV-LLGASSTEQLYENLQAIQ 301
|
....*..
gi 766431913 239 I--KLTP 243
Cdd:cd19141 302 VlpKLTP 308
|
|
| AKR_AKR3F2 |
cd19139 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; ... |
7-247 |
3.26e-08 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381365 [Multi-domain] Cd Length: 248 Bit Score: 53.13 E-value: 3.26e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 7 RDQVVIATKFTTDykgydvgkgksaNFcgnHKRSLHVSVRDSLRKLQTDWIDILYVHW--WDYMSSIEEVMDSLHILVQQ 84
Cdd:cd19139 54 RDELFITTKIWID------------NL---SKDKLLPSLEESLEKLRTDYVDLTLIHWpsPNDEVPVEEYIGALAEAKEQ 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 85 GKVLYLGVSDtpawvvsaanyyatshgktpFSIYQ--------GKWNVLNRDFErdiipmarhfgmaLAPWdvmgggrFQ 156
Cdd:cd19139 119 GLTRHIGVSN--------------------FTIALldeaiavvGAGAIATNQIE-------------LSPY-------LQ 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 157 SKKAVEERKKKGEGLrtffgTSEQTDMEVKI--SEALLKVAEEHGTeSVTAIAIAYVRSKAKHVFPlvGGRKIEHLKQNI 234
Cdd:cd19139 159 NRKLVAHCKQHGIHV-----TSYMTLAYGKVldDPVLAAIAERHGA-TPAQIALAWAMARGYAVIP--SSTKREHLRSNL 230
|
250
....*....|...
gi 766431913 235 EALSIKLTPEQIK 247
Cdd:cd19139 231 LALDLTLDADDMA 243
|
|
| AKR_unchar |
cd19099 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
7-235 |
9.16e-08 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381325 [Multi-domain] Cd Length: 316 Bit Score: 52.32 E-value: 9.16e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 7 RDQVVIATK---FTTDYKGYDVGKGKSANFCGNHKRSLHVSVRD---------------SLRKLQTDWIDILYVH----- 63
Cdd:cd19099 68 RDEVVIVTKagyIPGDGDEPLRPLKYLEEKLGRGLIDVADSAGLrhcispayledqierSLKRLGLDTIDLYLLHnpeeq 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 64 -----WWDYMSSIEEVMDSLHILVQQGKVLYLGVS-DTPAWVVSAANYYATS--------------HG----KTPFSIYQ 119
Cdd:cd19099 148 llelgEEEFYDRLEEAFEALEEAVAEGKIRYYGIStWDGFRAPPALPGHLSLeklvaaaeevggdnHHfkviQLPLNLLE 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 120 -----GKWNVLNRDFErdIIPMARHFGMAlapwdVMGGGRFQSKKAVEERkkkgeglrtffgtseqtdmevkiseALLKV 194
Cdd:cd19099 228 pealtEKNTVKGEALS--LLEAAKELGLG-----VIASRPLNQGQLLGEL-------------------------RLADL 275
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 766431913 195 AEEHGTESVTAIAIAYVRSKAKHVFPLVGGRKIEHLKQNIE 235
Cdd:cd19099 276 LALPGGATLAQRALQFARSTPGVDSALVGMRRPEHVDENLA 316
|
|
| AKR_galDH-like |
cd19153 |
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ... |
7-100 |
1.77e-07 |
|
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381379 [Multi-domain] Cd Length: 294 Bit Score: 51.38 E-value: 1.77e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 7 RDQVVIATKfttdykgydVGKGKSANFcgNHKRS-LHVSVRDSLRKLQTDWIDILYVH---WWDYMSSIEEVMDSLHILV 82
Cdd:cd19153 76 RSSYTVATK---------VGRYRDSEF--DYSAErVRASVATSLERLHTTYLDVVYLHdieFVDYDTLVDEALPALRTLK 144
|
90 100
....*....|....*....|..
gi 766431913 83 QQGKVLYLGVS----DTPAWVV 100
Cdd:cd19153 145 DEGVIKRIGIAgyplDTLTRAT 166
|
|
| AKR_KCAB1B_AKR6A3-like |
cd19159 |
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo ... |
7-253 |
2.21e-07 |
|
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo sapiens, Mus musculus, Mustela putorius, Rattus norvegicus, and Kvb1.1, Kvb1.2 from Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A3 (AKR6A3), A8 (AKR6A8), A10a (AKR6A10a), A13 (AKR6A13), A7 (AKR6A7) and A10b (AKR6A10b), respectively. KCAB1B, also called Shaker channel b-subunit 1(Kvb1), K(+) channel subunit beta-1, or Kv-beta-1, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It modulates action potentials via its effect on the pore-forming alpha subunits.
Pssm-ID: 381385 [Multi-domain] Cd Length: 323 Bit Score: 51.20 E-value: 2.21e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 7 RDQVVIATKFttdYKGydvgkGKSANFCGNHKRSLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEVMDSLHILVQQGK 86
Cdd:cd19159 74 RSSLVITTKL---YWG-----GKAETERGLSRKHIIEGLKGSLQRLQLEYVDVVFANRPDSNTPMEEIVRAMTHVINQGM 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 87 VLYLGVSDTPAWVVSAANYYATSHGKTPFSIYQGKWNVLNRDFERDIIPMARH-FGMALAPWDVMGGGRFQSK--KAVEE 163
Cdd:cd19159 146 AMYWGTSRWSAMEIMEAYSVARQFNMIPPVCEQAEYHLFQREKVEVQLPELYHkIGVGAMTWSPLACGIISGKygNGVPE 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 164 RKKKG----EGLRTFFGTSEQTDMEVKISEaLLKVAEEHGTeSVTAIAIAYVRSKAKHVFPLVGGRKIEHLKQNIEALSI 239
Cdd:cd19159 226 SSRASlkcyQWLKERIVSEEGRKQQNKLKD-LSPIAERLGC-TLPQLAVAWCLRNEGVSSVLLGSSTPEQLIENLGAIQV 303
|
250
....*....|....*.
gi 766431913 240 --KLTPEQIKYLESIV 253
Cdd:cd19159 304 lpKMTSHVVNEIDNIL 319
|
|
| AKR_FDH |
cd19162 |
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S, ... |
44-244 |
2.77e-07 |
|
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.
Pssm-ID: 381388 [Multi-domain] Cd Length: 290 Bit Score: 50.82 E-value: 2.77e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 44 SVRDSLRKLQTDWIDILYVHWWD--YMSSIEEVMDSLHILVQQGKVLYLGVSDTpawVVSAANYYATSHGKTPFSIyQGK 121
Cdd:cd19162 98 SIEASLERLGLDRLDLVFLHDPDrhLLQALTDAFPALEELRAEGVVGAIGVGVT---DWAALLRAARRADVDVVMV-AGR 173
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 122 WNVLNRDFERDIIPMARHFGMALAPWDVMGGG----------RFQSKKAVEERKKKGEGLRTffgtseqtdmevkiseal 191
Cdd:cd19162 174 YTLLDRRAATELLPLCAAKGVAVVAAGVFNSGilatddpagdRYDYRPATPEVLARARRLAA------------------ 235
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 766431913 192 lkVAEEHGTESVTAiAIAYVRSKAKHVFPLVGGRKIEHLKQNIEALSIKLTPE 244
Cdd:cd19162 236 --VCRRYGVPLPAA-ALQFPLRHPAVASVVVGAASPAELRDNLALLRTPIPAE 285
|
|
| AKR_unchar |
cd19098 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
72-253 |
7.21e-07 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381324 [Multi-domain] Cd Length: 318 Bit Score: 49.65 E-value: 7.21e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 72 EEVMDSLHILVQQGKVLYLGVSDTPAWVVSAANYYATSHGKTPFSIYQGKWNVlnrdFERDIIP---MARHFGMALAPWD 148
Cdd:cd19098 143 ADVLAALAELKAEGVKIGLSLSGPQQAETLRRALEIEIDGARLFDSVQATWNL----LEQSAGEaleEAHEAGMGVIVKE 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 149 VMGGGRFqskkaveerkkkgeglrtffgTSEQTDMEVK-ISEALLKVAEEHGTeSVTAIAIAYVRSKAKHVFPLVGGRKI 227
Cdd:cd19098 219 ALANGRL---------------------TDRNPSPELApLMAVLKAVADRLGV-TPDALALAAVLAQPFVDVVLSGAATP 276
|
170 180
....*....|....*....|....*.
gi 766431913 228 EHLKQNIEALSIKLTPEQIKYLESIV 253
Cdd:cd19098 277 EQLRSNLRALDVSLDLELLAALADLA 302
|
|
| AKR_unchar |
cd19104 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
6-252 |
1.39e-06 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381330 [Multi-domain] Cd Length: 321 Bit Score: 48.80 E-value: 1.39e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 6 LRDQVVIATKfttdykgYDVGKGKSANFCGNHKRSLHvsvrDSLRKLQTDWIDILYVH------------------WWDY 67
Cdd:cd19104 71 LPAGPYITTK-------VRLDPDDLGDIGGQIERSVE----KSLKRLKRDSVDLLQLHnrigderdkpvggtlsttDVLG 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 68 MssiEEVMDSLHILVQQGKVLYLGVSdtpAWVVSAANYYATSHGKtpFSIYQGKWNVLN-----------RDFE-RDIIP 135
Cdd:cd19104 140 L---GGVADAFERLRSEGKIRFIGIT---GLGNPPAIRELLDSGK--FDAVQVYYNLLNpsaaearprgwSAQDyGGIID 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 136 MARHFGMAlapwdVMGGGRFQSKKAVEERKKKGEGLRTFFGTSEQtdmEVKISEALLKVAEEHGtESVTAIAIAYVRSKA 215
Cdd:cd19104 212 AAAEHGVG-----VMGIRVLAAGALTTSLDRGREAPPTSDSDVAI---DFRRAAAFRALAREWG-ETLAQLAHRFALSNP 282
|
250 260 270
....*....|....*....|....*....|....*...
gi 766431913 216 KHVFPLVGGRKIEHLKQNIEALSI-KLTPEQIKYLESI 252
Cdd:cd19104 283 GVSTVLVGVKNREELEEAVAAEAAgPLPAENLARLEAL 320
|
|
| AKR_KCAB2B_AKR6A1-like |
cd19158 |
voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos ... |
7-253 |
2.23e-06 |
|
voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos taurus, Rattus norvegicus, Mus musculus, Homo sapiens, and Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A1 (AKR6A1), A2 (AKR6A2), A4 (AKR6A4), A5 (AKR6A5), and A6 (AKR6A6), respectively. KCAB2B, also called Shaker channel b-subunit 2 (Kvb2), or K(+) channel subunit beta-2, or Kv-beta-2, or Kvbeta2, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It may be involved in the regulation of nerve signaling, and prevents neuronal hyperexcitability.
Pssm-ID: 381384 [Multi-domain] Cd Length: 324 Bit Score: 48.16 E-value: 2.23e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 7 RDQVVIATKFttdYKGydvgkGKSANFCGNHKRSLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEVMDSLHILVQQGK 86
Cdd:cd19158 74 RSSLVITTKI---FWG-----GKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQGM 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 87 VLYLGVSDTPAWVVSAANYYATSHGKTPFSIYQGKWNVLNRDFERDIIPMARH-FGMALAPWDVMG----GGRFQSKKAV 161
Cdd:cd19158 146 AMYWGTSRWSSMEIMEAYSVARQFNLIPPICEQAEYHMFQREKVEVQLPELFHkIGVGAMTWSPLAcgivSGKYDSGIPP 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 162 EERK--KKGEGLRTFFGTSEQTDMEVKISEaLLKVAEEHGTeSVTAIAIAYVRSKAKHVFPLVGGRKIEHLKQNIEALSI 239
Cdd:cd19158 226 YSRAslKGYQWLKDKILSEEGRRQQAKLKE-LQAIAERLGC-TLPQLAIAWCLRNEGVSSVLLGASNAEQLMENIGAIQV 303
|
250
....*....|....*.
gi 766431913 240 --KLTPEQIKYLESIV 253
Cdd:cd19158 304 lpKLSSSIVHEIDSIL 319
|
|
| AKR_ARA2 |
cd19164 |
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+) ... |
42-96 |
4.71e-06 |
|
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381390 [Multi-domain] Cd Length: 298 Bit Score: 47.27 E-value: 4.71e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 766431913 42 HVSVRDSLRKLQTDWIDILYVHWWDYMSSiEEVMDSLHILVQ---QGKVLYLGVSDTP 96
Cdd:cd19164 102 RASVERSLRRLHTDYLDLVYLHDVEFVAD-EEVLEALKELFKlkdEGKIRNVGISGYP 158
|
|
| dkgB |
PRK11172 |
2,5-didehydrogluconate reductase DkgB; |
7-94 |
6.49e-05 |
|
2,5-didehydrogluconate reductase DkgB;
Pssm-ID: 183012 [Multi-domain] Cd Length: 267 Bit Score: 43.47 E-value: 6.49e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 7 RDQVVIATKFTTDykgyDVGKGKsanfcgnhkrsLHVSVRDSLRKLQTDWIDILYVHW--WDYMSSIEEVMDSLHILVQQ 84
Cdd:PRK11172 56 RDELFITTKIWID----NLAKDK-----------LIPSLKESLQKLRTDYVDLTLIHWpsPNDEVSVEEFMQALLEAKKQ 120
|
90
....*....|
gi 766431913 85 GKVLYLGVSD 94
Cdd:PRK11172 121 GLTREIGISN 130
|
|
| AKR_AKR3C2-3 |
cd19120 |
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis ... |
44-247 |
1.45e-04 |
|
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins; Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase (EC 1.1.1.190/EC 1.1.1.191) and Candida parapsilosis NADPH-dependent CPR (EC 1.1.1.358/EC 1.1.1.168) are founding members of aldo-keto reductase family 3 member C2 (AKR3C2) and C3 (AKR3C3), respectively. Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase catalyzes the conversion from (Indol-3-yl)ethanol to (indol-3-yl)acetaldehyde in a NAD/NADP-dependent manner. CPR, also called 2-dehydropantolactone reductase, or 2-dehydropantolactone reductase (A-specific), or ketopantoyl-lactone reductase, acts as a NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. It reduces ketopantoyl lactone and isatin.
Pssm-ID: 381346 [Multi-domain] Cd Length: 269 Bit Score: 42.60 E-value: 1.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 44 SVRDSLRKLQTDWIDILYVH--WWDYMS--SIEEVMDSLHILVQQGKVLYLGVSdtpawvvsaaNYYAT------SHGKT 113
Cdd:cd19120 84 ALRKSLAKLGVDYVDLYLIHspFFAKEGgpTLAEAWAELEALKDAGLVRSIGVS----------NFRIEdleellDTAKI 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 114 PFSIYQGKWNVLNRDFERDIIPMARHFGMA------LAP-WDVMGGgrfqskkaveerkkkgeglrtffgtseqtdmevK 186
Cdd:cd19120 154 KPAVNQIEFHPYLYPQQPALLEYCREHGIVvsayspLSPlTRDAGG---------------------------------P 200
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 766431913 187 ISEALLKVAEEHGtESVTAIAIAYVRskAKHVFPLVGGRKIEHLKQNIEALSIKLTPEQIK 247
Cdd:cd19120 201 LDPVLEKIAEKYG-VTPAQVLLRWAL--QKGIVVVTTSSKEERMKEYLEAFDFELTEEEVE 258
|
|
| AKR_AKR15A1 |
cd19161 |
Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium ... |
44-244 |
1.61e-04 |
|
Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium luteolum PLD (EC1.1.1.107) is a founding member of aldo-keto reductase family 15 member A1 (AKR15A1). It catalyzes irreversible oxidation of pyridoxal.
Pssm-ID: 381387 [Multi-domain] Cd Length: 310 Bit Score: 42.31 E-value: 1.61e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 44 SVRDSLRKLQTDWIDILYVHWWDYMSSIEE--------VMDS----LHILVQQG--KVLYLGVSDTPAwVVSAANYYats 109
Cdd:cd19161 108 SFEDSLQRLGLNRIDILYVHDIGVYTHGDRkerhhfaqLMSGgfkaLEELKKAGviKAFGLGVNEVQI-CLEALDEA--- 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 110 hgktPFSIY--QGKWNVLNRDFERDIIPMARHFGMALAPwdvmgGGRFQSKKAVeerkkKGEGLRTFFGTSEQTDMEVKI 187
Cdd:cd19161 184 ----DLDCFllAGRYSLLDQSAEEEFLPRCEQRGTSLVI-----GGVFNSGILA-----TGTKSGAKFNYGDAPAEIISR 249
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 766431913 188 SEALLKVAEEHGTESVTAiAIAYV-RSKA-KHVfpLVGGRKIEHLKQNIEALSIKLtPE 244
Cdd:cd19161 250 VMEIEKICDAYNVPLAAA-ALQFPlRHPAvASV--LTGARNPAQLRQNVEAFQTDI-PE 304
|
|
| PLN02587 |
PLN02587 |
L-galactose dehydrogenase |
7-96 |
2.39e-04 |
|
L-galactose dehydrogenase
Pssm-ID: 178198 [Multi-domain] Cd Length: 314 Bit Score: 42.07 E-value: 2.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 7 RDQVVIATKFTTDYKGYDVGKGKSANfcgnhkrslhvSVRDSLRKLQTDWIDILYVHWWDYMS---SIEEVMDSLHILVQ 83
Cdd:PLN02587 74 REKYVVSTKCGRYGEGFDFSAERVTK-----------SVDESLARLQLDYVDILHCHDIEFGSldqIVNETIPALQKLKE 142
|
90
....*....|...
gi 766431913 84 QGKVLYLGVSDTP 96
Cdd:PLN02587 143 SGKVRFIGITGLP 155
|
|
| AKR_CeZK1290-like |
cd19135 |
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the ... |
7-93 |
2.58e-04 |
|
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381361 [Multi-domain] Cd Length: 265 Bit Score: 41.54 E-value: 2.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 7 RDQVVIATK-FTTDYkGYDvgkgksanfcgNHKRSLHvsvrDSLRKLQTDWIDILYVHWWDYMSS-------IEEVMDSL 78
Cdd:cd19135 66 REDLFLTTKlWPSDY-GYE-----------STKQAFE----ASLKRLGVDYLDLYLLHWPDCPSSgknvketRAETWRAL 129
|
90
....*....|....*
gi 766431913 79 HILVQQGKVLYLGVS 93
Cdd:cd19135 130 EELYDEGLCRAIGVS 144
|
|
| AKR_AKR5C2 |
cd19131 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; ... |
7-94 |
7.05e-04 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; Escherichia coli DkgA/YqhE is a founding member of aldo-keto reductase family 5 member C2 (AKR5C2). DkgA/YqhE (EC 1.1.1.274), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives.
Pssm-ID: 381357 [Multi-domain] Cd Length: 256 Bit Score: 40.43 E-value: 7.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 7 RDQVVIATKFTTDYKGYDvgkgksanfcgnhkRSLHvSVRDSLRKLQTDWIDILYVHWwdYMSSIEEVMDSLHILVQ--- 83
Cdd:cd19131 63 REELFITTKLWNSDQGYD--------------STLR-AFDESLRKLGLDYVDLYLIHW--PVPAQDKYVETWKALIElkk 125
|
90
....*....|.
gi 766431913 84 QGKVLYLGVSD 94
Cdd:cd19131 126 EGRVKSIGVSN 136
|
|
| AKR_AKR5F1 |
cd19133 |
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid ... |
44-93 |
3.98e-03 |
|
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid reductase (2,5-DKG reductase) is a founding member of aldo-keto reductase family 5 member F1 (AKR5F1). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381359 [Multi-domain] Cd Length: 255 Bit Score: 37.94 E-value: 3.98e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 766431913 44 SVRDSLRKLQTDWIDILYVHW--------WDYMssiEEvmdslhiLVQQGKVLYLGVS 93
Cdd:cd19133 85 AFERSLKRLGLDYLDLYLIHQpfgdvygaWRAM---EE-------LYKEGKIRAIGVS 132
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|
| AKR_AKR5A_5G |
cd19126 |
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes ... |
7-94 |
5.40e-03 |
|
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes prostaglandin F2-alpha synthase (PGFS) from Leishmania major (AKR5A1) and Trypanosoma brucei (AKR5A2). PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity for synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. The AKR5G family of AKR includes Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase, which corresponds to aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381352 [Multi-domain] Cd Length: 254 Bit Score: 37.42 E-value: 5.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 766431913 7 RDQVVIATKFTTDYKGYDvgKGKSAnfcgnhkrslhvsVRDSLRKLQTDWIDILYVHW---------WDYMssiEEVMDS 77
Cdd:cd19126 63 REELFVTTKLWNDDQRAR--RTEDA-------------FQESLDRLGLDYVDLYLIHWpgkdkfidtWKAL---EKLYAS 124
|
90
....*....|....*..
gi 766431913 78 lhilvqqGKVLYLGVSD 94
Cdd:cd19126 125 -------GKVKAIGVSN 134
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