NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1021221233|gb|AJR89183|]
View 

hypothetical protein H773_YJM975G00493 [Saccharomyces cerevisiae YJM975]

Protein Classification

adenine nucleotide alpha hydrolase family protein( domain architecture ID 188)

AANH (adenine nucleotide alpha hydrolase) family protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
AANH_superfamily super family cl00292
Adenine nucleotide alpha hydrolase (AANH) superfamily; The adenine nucleotide alpha hydrolase ...
 353-517 1.03e-03

Adenine nucleotide alpha hydrolase (AANH) superfamily; The adenine nucleotide alpha hydrolase (AANH) superfamily includes N-type ATP PPases, ATP sulfurylases, universal stress response proteins (USPs), and electron transfer flavoproteins (ETFs). The domain forms an alpha/beta/alpha fold which binds to adenosine nucleotide.


The actual alignment was detected with superfamily member cd23659:

Pssm-ID: 469708  Cd Length: 143  Bit Score: 40.30  E-value: 1.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021221233 353 VDWYVENLARNGDHLVIITTIPEFEakidtlaykekrrhrlermtsntsesmttashsligPDLSSPLSTGIRIEAIHNE 432
Cdd:cd23659    17 LEWALENLHRPGDEVVLLHVIEPPS------------------------------------LPAASLGSGSEEWEALEEE 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021221233 433 AKQTCSDILNYYARRLAT-KIVRISIEMVKEDStRSAIISATSLYRPSLQVISTvsaniqikfRN-GKVKLPF------F 504
Cdd:cd23659    61 AREKAEKLLEKYEKKLKEeKGIKVKVEVVAGDP-GEVICKAAEELKADLIVMGS---------RGlGALKRTLlgsvsdY 130

                         170
                  ....*....|...
gi 1021221233 505 LMKHFAMPAFVVP 517
Cdd:cd23659   131 VVHHSPCPVLVVR 143
 
Name Accession Description Interval E-value
USP_At3g01520-like cd23659
universal stress protein At3g01520 and similar proteins; This subfamily includes plant and ...
 353-517 1.03e-03

universal stress protein At3g01520 and similar proteins; This subfamily includes plant and fungal proteins of unknown function, including Arabidopsis thaliana At3g01520. A. thaliana contains 44 USP domain-containing proteins; the USP domain is found either in a small protein with unknown physiological function or as an N-terminal portion of a multi-domain protein, usually a protein kinase. The gene At3g01520 of Arabidopsis thaliana encodes a 175-residue universal stress protein (USP)-like protein which is widely found in the genomes of bacteria, as well as fungi, protozoa, and plants. The bound AMP and conservation of residues in the ATP-binding loop suggest that the protein At3g01520 belongs to the ATP-binding USP subfamily. Universal stress proteins (USPs) are small cytoplasmic bacterial proteins whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467505  Cd Length: 143  Bit Score: 40.30  E-value: 1.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021221233 353 VDWYVENLARNGDHLVIITTIPEFEakidtlaykekrrhrlermtsntsesmttashsligPDLSSPLSTGIRIEAIHNE 432
Cdd:cd23659    17 LEWALENLHRPGDEVVLLHVIEPPS------------------------------------LPAASLGSGSEEWEALEEE 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021221233 433 AKQTCSDILNYYARRLAT-KIVRISIEMVKEDStRSAIISATSLYRPSLQVISTvsaniqikfRN-GKVKLPF------F 504
Cdd:cd23659    61 AREKAEKLLEKYEKKLKEeKGIKVKVEVVAGDP-GEVICKAAEELKADLIVMGS---------RGlGALKRTLlgsvsdY 130

                         170
                  ....*....|...
gi 1021221233 505 LMKHFAMPAFVVP 517
Cdd:cd23659   131 VVHHSPCPVLVVR 143
 
Name Accession Description Interval E-value
USP_At3g01520-like cd23659
universal stress protein At3g01520 and similar proteins; This subfamily includes plant and ...
 353-517 1.03e-03

universal stress protein At3g01520 and similar proteins; This subfamily includes plant and fungal proteins of unknown function, including Arabidopsis thaliana At3g01520. A. thaliana contains 44 USP domain-containing proteins; the USP domain is found either in a small protein with unknown physiological function or as an N-terminal portion of a multi-domain protein, usually a protein kinase. The gene At3g01520 of Arabidopsis thaliana encodes a 175-residue universal stress protein (USP)-like protein which is widely found in the genomes of bacteria, as well as fungi, protozoa, and plants. The bound AMP and conservation of residues in the ATP-binding loop suggest that the protein At3g01520 belongs to the ATP-binding USP subfamily. Universal stress proteins (USPs) are small cytoplasmic bacterial proteins whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467505  Cd Length: 143  Bit Score: 40.30  E-value: 1.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021221233 353 VDWYVENLARNGDHLVIITTIPEFEakidtlaykekrrhrlermtsntsesmttashsligPDLSSPLSTGIRIEAIHNE 432
Cdd:cd23659    17 LEWALENLHRPGDEVVLLHVIEPPS------------------------------------LPAASLGSGSEEWEALEEE 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021221233 433 AKQTCSDILNYYARRLAT-KIVRISIEMVKEDStRSAIISATSLYRPSLQVISTvsaniqikfRN-GKVKLPF------F 504
Cdd:cd23659    61 AREKAEKLLEKYEKKLKEeKGIKVKVEVVAGDP-GEVICKAAEELKADLIVMGS---------RGlGALKRTLlgsvsdY 130

                         170
                  ....*....|...
gi 1021221233 505 LMKHFAMPAFVVP 517
Cdd:cd23659   131 VVHHSPCPVLVVR 143
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH