|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
43-493 |
4.26e-80 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 255.18 E-value: 4.26e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 43 LTLVLFITALDILIVGTIIDVVAEQFGNHSKTGWLVTGYSLPNAILSLIWGRFASIIGFQHSLILAILIFEAGSLIAALA 122
Cdd:cd17502 1 LMLALFLAALDQTIVATALPTIVAEFGGLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 123 SSMNMLIVGRVVAGVGGSGLQTLCFVIGCTMVGERSRPLVISILSCAFAVAAIVGPIIGGAFTTHVTWRWCFYINLPIGG 202
Cdd:cd17502 81 PNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 203 LAIIMFlltykaenkgilqqikdaigtissftfskfrhqvnfkrlmngiifkfdffgfalcsaglvlfllgltfggnkys 282
Cdd:cd17502 161 LALALL-------------------------------------------------------------------------- 166
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 283 wnsgqviaylvlgvllfifslvydfflfdkfnpepdnisyrplllrrlvakPAIIIVNMVTFLLCTGYNGQMIYSVQFFQ 362
Cdd:cd17502 167 ---------------------------------------------------RTILLSSIFGFLFGGALFGLIYYLPLYFQ 195
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 363 LIFASSAWKAGLHLIPIVITNVIAAIASGVITKKLGLVKPLLIFGGVLGVIGAGLMTLMTNTSTKSTQIGVLLLPGFSLG 442
Cdd:cd17502 196 LVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRYKPLIVIGTILMSVGAGLLTTLTLDTSKWLLIGYLILLGLGLG 275
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 1095459775 443 FALQASLMSAQLQITKDrpeaamDFIEVTAFNTFMKSLGTTLGGVLsTTVF 493
Cdd:cd17502 276 IGFQQPLVAVQNAVPPA------DVGVATATNTFFRSLGGTLGVAI-TDVF 319
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
38-502 |
3.87e-47 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 172.81 E-value: 3.87e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 38 LCLASLTLVLFITALdilivGTIIDVVAEQFGNHSKTGWLVTGYSLPNAILSLIWGRFASIIGFQHSLILAILIFEAGSL 117
Cdd:cd06179 3 LCLAYFAQLFGVTLP-----AAVLPFIVADLGPSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSI 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 118 IAALASSMNMLIVGRVVAGVGGSGLQTLCFVIGcTMVGERSRPLVISILSCAFAVAAIVGPIIGGAFT--THVTWRWCFY 195
Cdd:cd06179 78 VAGTAKSVNMLIGGQALIGIGAGTQGLGAAVAS-ELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVeaNAAGWRWIFY 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 196 INLPIGGLAIIMFLLTYK------AENKGILQQIKdaigtissftfskfrhqvnfkrlmngiifKFDFFGFALCSAGLVL 269
Cdd:cd06179 157 INAIFNALALILLFFFYHppprpqLHGSSTRQKLK-----------------------------RLDWVGLFLLIAGLVL 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 270 FLLGLTFGGNKYSWNSGQVIAYLVLGVLLFIFSLVYDFFlfdkFNPEPdniSYRPLLLRRLVAKPAIIIVNMVTFLLCTG 349
Cdd:cd06179 208 FLLGLSWGGNPYPWSSAHVIAPLVIGGVLLIAFGLYEWK----GTKDG---LLPPRLLFRGRNFALILIVAFVEGMIFYS 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 350 YNgqmIYSVQFFQLIFASSAWKAGLHLIPIVITNVIAAIASGVITKKLGLVKPLLIFGGVLGVIGAGLMTLmTNTSTKST 429
Cdd:cd06179 281 LN---IFWPQQISLLFTTDPLKAGLYQLPFGLGTLFGAILAGLLLTKIKHIKWQLVAGFVLFTAFLALLAL-ITPDNKAL 356
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1095459775 430 QIGVLLLPGFSLGFALQASLMSAQLqITKDRPEAamdfievTAFNTFMKSlgTTLGGVLSTTVFSASFHNKVS 502
Cdd:cd06179 357 AIAFSVLAGIGIGGPLVLAIVIVQL-SVPPEDIG-------TASGLLGSA--RALGGAVGTAIFTSILSNRLS 419
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
43-560 |
3.55e-38 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 144.62 E-value: 3.55e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 43 LTLVLFITALDILIVGTIIDVVAEQFG-NHSKTGWLVTGYSLPNAILSLIWGRFASIIGFQHSLILAILIFEAGSLIAAL 121
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGaSPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 122 ASSMNMLIVGRVVAGVGGSGLQTLCFVIGCTMVGERSRPLVISILSCAFAVAAIVGPIIGGAFTTHVTWRWCFYINLPIg 201
Cdd:cd17321 81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPI- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 202 glaiimflltykaenkgilqqikdaigtissftfskfrhqvnfkrlmngiifkfdffgfalcsaGLVLFLLGLTFGGnky 281
Cdd:cd17321 160 ----------------------------------------------------------------GLVALLLARTFSG--- 172
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 282 swnsgqviaylvlgvllfifslvydfflfdkfnpepdnisyrplllrrlvakpaiiiVNMVTFLLCTGYNGQMIYSVQFF 361
Cdd:cd17321 173 ---------------------------------------------------------AVLAAFLLGAALGGLLFLLPLYL 195
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 362 QLIFASSAWKAGLHLIPIVITNVIAAIASGVITKKLGlVKPLLIFGGVLGVIGAGLMTLMTNTSTKSTQIGVLLLPGFSL 441
Cdd:cd17321 196 QGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFG-PRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGL 274
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 442 GFALQASLMSAQLQITKDRPEAAmdfievTAFNTFMKSLGTTLGGVLSTTVFSASFHNKVSRAHlepyegktvddmilyr 521
Cdd:cd17321 275 GLFATPLTNAALSSVPKEKAGAA------SGILNTARQLGGALGVALLGALLTAGLSANLGDSG---------------- 332
|
490 500 510
....*....|....*....|....*....|....*....
gi 1095459775 522 lqnYDGSHSTIGNILSDSIKNVFWMDLGFYALGFLFCSF 560
Cdd:cd17321 333 ---VAALLSAAAAAFAAGFHLAFLVAAALALLAALLALL 368
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
42-560 |
1.21e-34 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 137.13 E-value: 1.21e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 42 SLTLVLFITALDILIVGTIIDVVAEQFGNHSKTG-WLVTGYSLPNAILSLIWGRFASIIGFQHSLILAILIFEAGSLIAA 120
Cdd:TIGR00711 6 VLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVqWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 121 LASSMNMLIVGRVVAGVGGSGLQTLCFVIGCTMVGERSRPLVISILSCAFAVAAIVGPIIGGAFTTHVTWRWCFYINLPI 200
Cdd:TIGR00711 86 VAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 201 GGLAIIMFLLTYKAENKGILQqikdaigtissftfskfrhqvnfkrlmngiifKFDFFGFALCSAGLVLFLLGLTFGGNK 280
Cdd:TIGR00711 166 GIIVVVVAFFILPRDKPAASE--------------------------------NFDFLGLLLLSVGLGSLLYGLSEGPER 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 281 YSWNSGQVIAYLVLGVLLFIFSLVYDFflfdkfnpepdnISYRPLLLRRLVAKPAIIIVNMVTFLLCTGYNGQMIYSVQF 360
Cdd:TIGR00711 214 GWFDSNEILILSITGLVAIIAFVVWEL------------TDDNPLVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLY 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 361 FQLIFASSAWKAGLHLIPIVITNVIAAIASGVITKKLGLvKPLLIFGGVLGVIGAGLMTLMTNTSTKSTQIgvlLLPGFS 440
Cdd:TIGR00711 282 LQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDP-RKLVTIGLILYAVGFYWRAFTFTPDTPFLAI---ALPQFI 357
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 441 LGFALQASLMSAQLQITKDRPEaamdfiEVTAFNTFMKSLGTTLGGVLSTTVFSASFHNKVSRAHLEPYEG-KTVDDMIL 519
Cdd:TIGR00711 358 RGFGMGCFFMPLTTIALSGLPP------HKIARGSSLSNFTRQLGGSIGTALITTILTNRTQFHHSQLTETiNPVNPNFL 431
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|...
gi 1095459775 520 YRLQNY-------DGSHSTIGNI-----LSDSIKNVFWMDLGFYALGFLFCSF 560
Cdd:TIGR00711 432 SGYSQLaalgnpeQQVYALIAQQitlhaFSIAINEIFWMATLLFVSGLILIWF 484
|
|
| MFS_ARN_like |
cd17322 |
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major ... |
36-503 |
1.61e-26 |
|
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; The ARN family of siderophore iron transporters includes ARN1 (or ferrichrome permease), ARN2 (or triacetylfusarinine C transporter 1 or TAF1), ARN3 (or siderophore iron transporter 1 or SIT1 or ferrioxamine B permease) and ARN4 (or Enterobactin permease or ENB1). They specifically recognize siderophore-iron chelates are expressed under conditions of iron deprivation. They facilitate the uptake of both hydroxamate- and catecholate-type siderophores. This group also includes glutathione exchanger 1 (Gex1p) and Gex2p, which are proton/glutathione antiporters that import glutathione from the vacuole and exports it through the plasma membrane. The ARN family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340880 [Multi-domain] Cd Length: 514 Bit Score: 113.56 E-value: 1.61e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 36 LYLCLASLTLVLFITALDILIVGTIIDVVAEQFGNHSKTGWLVTGYSLPNAILSLIWGRFASIIGFQHSLILAILIFEAG 115
Cdd:cd17322 1 LIILFFSLFLCGFAIGLDGQIRYSYQAYATSSFSKHSLLSTINVVNNIVSAVSQPPYAKLSDVFGRLELFLVSLLLYVVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 116 SLIAALASSMNMLIVGRVVAGVGGSGLQTLCFVIGCTMVGERSRPLVISILSCAFAVAAIVGPIIGGAFTTHVTWRW--- 192
Cdd:cd17322 81 TIIMAASTNVQTYAAGSVFYNAGYTGLNLLLTLILADFSSLKNRGFASAIPSLPYIITTWIGGNIAQAALPNSNWRWgyg 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 193 CFYINLPIGG--LAIIMFLLTYKAENKGILQQIKDAIGTISSFTFSKfrhqvNFKRLmngiIFKFDFFGFALCSAGLVLF 270
Cdd:cd17322 161 MWAIILPLSSlpLVLCLLYMQRKARKDGEIKELKNQETEEQTGGLSQ-----NLVKL----FWKLDIFGVILLTAGLGLI 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 271 LLGLTF-GGNKYSWNSGQVIAYLVLGVLLFIFSLVYDFFlfdkfnpepdnISYRPLLLRRLVAKPAIIIVNMVTFLLCTG 349
Cdd:cd17322 232 LVPLTLaGGAKSKWKNSSIIAMIVLGGVLLVAFLLWEAK-----------FAKYPFLPFRLLKDRTILAACLIDFFYFFS 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 350 YNGQMIYSVQFFQLIFASSAWKAGLHLIPIVITNVIAAIASGVITKKLGLVKPLLIFGGVLGVIGAGLMTLM-TNTSTKS 428
Cdd:cd17322 301 YYIFSDYLYTVLQVAVGESITSATRITNLYSFVSTVAGIFVGFLIRKTRRYKVLVIIGVPLYIVGMGLLIRYrGGSGSHG 380
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1095459775 429 TQIGVLLLPGFSLGFAlqASLMSAQLQITKDRPEAAMdfieVTAFNTFMKSLGTTLGGVLSTTVFSASFHNKVSR 503
Cdd:cd17322 381 GIIGALILIGIGGGLF--TYPVQVSVQASVSHQEMAV----VTALLLTVYSIGGAVGAAISGAIWTQTLPKKLLK 449
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
40-484 |
4.22e-22 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 97.74 E-value: 4.22e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 40 LASLTLVLFITALDILIVGTIIDVVAEQFG-NHSKTGWLVTGYSLPNAILSLIWGRFASIIGFQHSLILAILIFEAGSLI 118
Cdd:COG2814 12 LLALALGAFLSGLGIGIVLPALPLIAADLGaSPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 119 AALASSMNMLIVGRVVAGVGGSGLQTLCFVIGCTMVGERSRPLVISILSCAFAVAAIVGPIIGGAFTTHVTWRWCFYINL 198
Cdd:COG2814 92 CALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNA 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 199 PIGGLAIIMFLLTYKAENKGILQQIKDAigtissftfskfrhqvnfkrlmngiifkfdffgfalcsaglvlfllgltfgg 278
Cdd:COG2814 172 VLALLALLLLLRLLPESRPAARARLRGS---------------------------------------------------- 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 279 nkyswnsgqviaylvlgvllfifslvydfflfdkfnpepdnisyrpllLRRLVAKPAIIIVNMVTFLLCTGYNGQMIYSV 358
Cdd:COG2814 200 ------------------------------------------------LRELLRRPRLLLLLLLAFLLGFGFFALFTYLP 231
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 359 QFFQLIFASSAWKAGLHLIPIVITNVIAAIASGVITKKLGLvKPLLIFGGVLGVIGAGLMTLMTNtstkstqIGVLLLPG 438
Cdd:COG2814 232 LYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGR-RRLLLIGLLLLALGLLLLALAGS-------LWLLLLAL 303
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 1095459775 439 FSLGFALQASLMSAQLQITKDRPEAAMDfiEVTAFNTFMKSLGTTL 484
Cdd:COG2814 304 FLLGFGFGLLFPLLQALVAELAPPEARG--RASGLYNSAFFLGGPL 347
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
40-310 |
2.71e-21 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 94.49 E-value: 2.71e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 40 LASLTLVLFITALDILIVGTIIDVVAEQFG-NHSKTGWLVTGYSLPNAILSLIWGRFASIIGFQHSLILAILIFEAGSLI 118
Cdd:COG0477 16 LLALALGTFLEGLDFTIVNVALPSIAADLGaSSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 119 AALASSMNMLIVGRVVAGVGGSGLQTLCFVIGCTMVGERSRPLVISILSCAFAVAAIVGPIIGGAFTTHVTWRWCFYINL 198
Cdd:COG0477 96 CGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINA 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 199 PIGGLAIIMFLLTYKAENkGILQQIKDAIGTISSFTFSKFRHQVNFKRLMNGIIFKFDFFGFALCSAGLVLFLLGLTFGG 278
Cdd:COG0477 176 PLGLLALVLRLRLPESRG-LLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLL 254
|
250 260 270
....*....|....*....|....*....|..
gi 1095459775 279 NKYSWNSGQVIAYLVLGVLLFIFSLVYDFFLF 310
Cdd:COG0477 255 ALLLLAALLLLLLLLLLLALLLALLLLLLLLL 286
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
43-207 |
6.44e-20 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 91.87 E-value: 6.44e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 43 LTLVLFITALDILIVGTIIDVVAEQFG-NHSKTGWLVTGYSLPNAILSLIWGRFASIIGFQHSLILAILIFEAGSLIAAL 121
Cdd:cd17503 1 LLLGAFMAILDTTIVNVALPTIMGDLGaSLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 122 ASSMNMLIVGRVVAGVGGSGLQTLCFVIGCTMVGERSRPLVISILSCAFAVAAIVGPIIGGAFTTHVTWRWCFYINLPIG 201
Cdd:cd17503 81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIG 160
|
....*.
gi 1095459775 202 GLAIIM 207
Cdd:cd17503 161 ILALLL 166
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
43-394 |
1.19e-16 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 81.70 E-value: 1.19e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 43 LTLVLFITALDI-LIVGTIIDVVAEQFG-NHSKTGWLVTGYSLPNAILSLIWGRFASIIGFQHSLILAILIFEAGSLIAA 120
Cdd:pfam07690 1 LFLAAFLAALGRsLLGPALPLLLAEDLGiSPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 121 LASSMNMLIVGRVVAGVGGSGLQTLCFVIGCTMVGERSRPLVISILSCAFAVAAIVGPIIGGAFTTHVTWRWCFYINLPI 200
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 201 GGLAIIMFLLTYKAENKGILQQIKDAiGTISSFTFSKFRHQVNFKRLMNGIIFKFDFFGFAlcsagLVLFLLGLTFGgnk 280
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEA-RLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLL-----TYLPLYQEVLG--- 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 281 ysWNSGQVIAYLVLGVLLFIFSLVYDFFLFDKFNPEPdnisyrplllRRLVAKPAIIIVNMVTFLLCTGYNGQMIYSVQF 360
Cdd:pfam07690 232 --LSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRR----------RLLLALLLLILAALGLLLLSLTLSSLWLLLALL 299
|
330 340 350
....*....|....*....|....*....|....
gi 1095459775 361 FQLIFASSAWKAGLHLIPIVITNVIAAIASGVIT 394
Cdd:pfam07690 300 LLGFGFGLVFPALNALVSDLAPKEERGTASGLYN 333
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
43-445 |
4.34e-14 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 74.00 E-value: 4.34e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 43 LTLVLFITALDILIVGTIIDVVAEQFG-NHSKTGWLVTGYSLPNAILSLIWGRFASIIGFQHSLILAILIFEAGSLIAAL 121
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGlSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 122 ASSMNMLIVGRVVAGVGGSGLQTLCFVIGCTMVGERSRPLVISILSCAFAVAAIVGPIIGGAFTTHVT--WRWCFYINLP 199
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGfgWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 200 IGGLAIIMFLLTYKAENKGILQQIKDAigtissftFSKFRHQVNFKRLMNGIIFKFDFFGFALCSAGLVLFLLGLTFGGN 279
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEA--------SSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLD 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 280 KYSWNSGQVIAYLVLGVLLFIFSLVYDFFLFDKFnpepdnisyrplLLRRLVAKPAIIIVNMVTFLLCTGYNGQMIYSVQ 359
Cdd:cd06174 233 LGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRL------------IGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLL 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 360 FFQLIFASSAWKAGLHLIPIVITNVIAAIASGVITkklglvkpllIFGGVLGVIGAGLMTLMTNTSTKSTQIGVLLLPGF 439
Cdd:cd06174 301 LLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLN----------TFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLL 370
|
....*.
gi 1095459775 440 SLGFAL 445
Cdd:cd06174 371 LLAAIL 376
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
64-497 |
4.56e-13 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 72.01 E-value: 4.56e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 64 VAEQFGNHSKTGWLVTGYSLPNAILSLIWGRFASIIGFQHSLILAILIFEAGSLIAALASSMNMLIVGRVVAGVGGSGLQ 143
Cdd:pfam06609 70 ILQDIGQSENQGLFSTLWTMGQAVSILMMGRLTDRFGRRPFVIATHIIGLVGAIVGCTANKFNTLLAAMTLLGVAAGPAG 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 144 TLCFVIGcTMVGERSRPLVISILSCAFAVAAIVGPIIGGAFTTHVTWRWCFYINLPIGGLAIIMFLLTYKAEnkgilqqi 223
Cdd:pfam06609 150 ASPLFIG-ELMSNKTKFLGLLIVSAPTIAMNGAGPYFGQRLAIQGNWRWIFYIYIIMSAIAVLLIIIWYHPP-------- 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 224 kdaigtissfTFSKFRHQVNFKRlmnGIIFKFDFFGFALCSAGLVLFLLGLTFGGNKYS-WNSGQVIAYLVLGV-LLFIF 301
Cdd:pfam06609 221 ----------SFAQLHGKKARKR---DELAKLDWIGIFLVIAGTSLFLLGVSWGGKPNNpWNSAKIIGLISSGAgSLVIF 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 302 SLvYDFFlfdkfnPEPDNISYRPLLLRRLVAKPAIIIVN--MVTFLLCTgyngQMIYSVQFFQlIFASSA--WKAglhli 377
Cdd:pfam06609 288 AL-YEVF------GKPEQPIIPPALFKDTRGFVCILIISsiMGAMHLCL----TIIYPQQVIN-IFGSSLknWEE----- 350
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 378 piviTNVIAAIASgvitkkLGLVKPLLIFGGVLGVI---------GAGLMTLM------TNTSTKSTQIGVLLLPGFSLG 442
Cdd:pfam06609 351 ----TAWMSATAS------FGTGAGVMILGNLFHLIrhirwqilvGALWLTAFlgamssINRDNKNAAIALSFFSGFVVA 420
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1095459775 443 FALQASLMSAQLqITKD-------------RPEAAMDFieVTAF-----NTFMKSLGTTLGGVLSTTVF-SASF 497
Cdd:pfam06609 421 WAQDITMLLVQF-ITTDedlgvafavvaaaRPFAGSIF--TAAFislysNQYPKEIASHLSSALRGTDFpQASF 491
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
43-496 |
1.51e-11 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 66.06 E-value: 1.51e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 43 LTLVLFITALDILIVGTIIDVVAEQFG-NHSKTGWLVTGYSLPNAILSLIWGRFASIIGFQHSLILAILIFEAGSLIAAL 121
Cdd:cd17504 1 LALAALAVMLVETMLSPALPTIQREFGtSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 122 ASSMNMLIVGRVVAGVGGSGLQtLCFVIGCTMVGERSRPLVISILSCAFAVAAIVGPIIGGAFTTHVTWRWCFYINLPIG 201
Cdd:cd17504 81 APNLPVLIAGRALQGIGGAVFP-LAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 202 GLAIIMFlltykaenkgilqqikdaigtissftfskfrhqvnfkrlmngiifkfdffgfalcsaglvlfllgltfggnky 281
Cdd:cd17504 160 VLLAALV------------------------------------------------------------------------- 166
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 282 swnsgqviaylvlgvllfifslvydfflfdkfnpepdnisyrPLLLRRLVAKPAIIIVNMVTFLLCTGYNGQMIYSVQFF 361
Cdd:cd17504 167 ------------------------------------------PLIDLRLLRRRNVLLANITALLAGFGMFMVFQLLPQLL 204
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 362 QL----IFASSAWKAGLHLIPIVITNVIAAIASGVITKKLGlVKPLLIFGGVLGVIGAGLMTLMtntSTKSTQIGVLLLp 437
Cdd:cd17504 205 QLptptGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVG-PRRVLLIGLVISAVGLLLLALL---HSSLWALVVALL- 279
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*....
gi 1095459775 438 GFSLGFALQASLMSAQLQITKDRPEAAmdfiEVTAFNTFMKSLGTTLGGVLSTTVFSAS 496
Cdd:cd17504 280 LIGIGLGLAFASLPNIVVESVPPDRTG----IATGMNTVLRTIGSAIGPAIAGAILTTY 334
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
42-213 |
1.52e-11 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 66.03 E-value: 1.52e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 42 SLTLVLFITALDILIVGTIIDVVAEQFG-NHSKTGWLVTGYSLPNAILSLIWGRFASIIGFQHSLILAILIFEAGSLIAA 120
Cdd:cd17324 3 ALALAAFAIGTTEYVIQGLLPDIARDFGvSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 121 LASSMNMLIVGRVVAGVGGSGLQTLCFVIGCTMVGERSRPLVISILSCAFAVAAIVGPIIGGAFTTHVTWRWCFYInlpI 200
Cdd:cd17324 83 LAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLA---I 159
|
170
....*....|...
gi 1095459775 201 GGLAIIMFLLTYK 213
Cdd:cd17324 160 AVLALLAALLLWR 172
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
40-211 |
1.53e-11 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 66.05 E-value: 1.53e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 40 LASLTLVLFITALDILIVGTIIDVVAEQFG-NHSKTGWLVTGYSLPNAILSLIWGRFASIIGFQHSLILAILIFEAGSLI 118
Cdd:COG2271 12 LALLFLAYFLNYLDRSNLSVAAPPLQADLGlSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 119 AALASSMNMLIVGRVVAGVGGSGLQTLCFVIGCTMVGERSRPLVISILSCAFAVAAIVGPIIGGAFTTHVTWRWCFYInl 198
Cdd:COG2271 92 FGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLI-- 169
|
170
....*....|...
gi 1095459775 199 pIGGLAIIMFLLT 211
Cdd:COG2271 170 -LGLPGLLLALLR 181
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
75-207 |
3.24e-11 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 61.13 E-value: 3.24e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 75 GWLVTGYSLPNAILSLIWGRFASIIGFQHSLILAILIFEAGSLIAALASSMNMLIVGRVVAGVGGSGlqtlCFVIGCTMV 154
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAF----ALVAGAALI 76
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1095459775 155 GERS----RPLVISILSCAFAVAAIVGPIIGGAFTTHVTWRWCFYINLPIGGLAIIM 207
Cdd:TIGR00880 77 ADIYppeeRGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFIL 133
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
43-317 |
1.02e-10 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 63.75 E-value: 1.02e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 43 LTLVLFITALDILIVGTIIDVVAEQFG-NHSKTGWLVTGYSLPNAILSLIWGRFASIIGFQHSLILAILIFEAGSLIAAL 121
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGaSVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 122 ASSMNMLIVGRVVAGVGGSGLQTLCFVIGCTMVGERSRPLVISILSCAFAVAAIVGPIIGGAFTTHVTWRWCFYInlpIG 201
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLV---CA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 202 GLAIIMFLLTYKAENKGILQQIKDAIGTISSFTFSKFRHQVNFKRLMNGIIFkFDFFGFALCSAGLVLFLLgltfggNKY 281
Cdd:cd17325 158 ALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIF-VLAFAFGALEPFLPLYAA------ELG 230
|
250 260 270
....*....|....*....|....*....|....*.
gi 1095459775 282 SWNSGQVIAYLVLGVLLFIFSLVYDFFLFDKFNPEP 317
Cdd:cd17325 231 GLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKP 266
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
40-235 |
2.22e-10 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 62.56 E-value: 2.22e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 40 LASLTLVLFITALDILIVGTIIDVVAEQFG-NHSKTGWLVTGYSLPNAILSLIWGRFASIIGFQHSLILAILIFEAGSLI 118
Cdd:COG0738 10 LIAIYLLFFLWGFATALWGPLIPALKDAFGlSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 119 AALASSMNMLIVGRVVAGVGGSGLQTLCFVIGcTMVGERSRPLVISILSCAFAVAAIVGPIIGGAFTTH---VTWRWCFY 195
Cdd:COG0738 90 FALAPSYPLLLLALFLLGLGLGLLDVAANPYV-AALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLglsLSWHLPYL 168
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 1095459775 196 InlpIGGLAIIMFLLTYKAENKGILQQIKDAIGTISSFTF 235
Cdd:COG0738 169 I---LAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKS 205
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
38-305 |
6.05e-10 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 61.44 E-value: 6.05e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 38 LCLASLTLvLFITALDILIVGtiIDVVAEQFG-NHSKTGWLVTGYSLPNAILSLIWGRFASIIGFQHSLILAILIFEAGS 116
Cdd:cd17320 2 LLLALLVA-LGPLAIDMYLPA--LPAIARDLGaSASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILAS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 117 LIAALASSMNMLIvgrvvagvGGSGLQTL----CFVIGCTMV----GERSRPLVISILSCAFAVAAIVGPIIGGAFTTHV 188
Cdd:cd17320 79 LLCALASSIEQLL--------IARFLQGLgaaaGSVVARAIVrdlySGAELAKIFSLLMMILAIAPALAPLLGGLLLLFF 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 189 TWRWCFYInlpIGGLAIIMFLLTYKAENKGilqQIKDAIGTISSFTFSKFRHqvnfkrlmngIIFKFDFFGFALCsaglv 268
Cdd:cd17320 151 GWRAIFVF---LALLGLLLLLLVLLFLPET---LPEEKRKPLLSSLLRAYKR----------VLKNRRFLGYALA----- 209
|
250 260 270
....*....|....*....|....*....|....*...
gi 1095459775 269 lflLGLTFGGNkYSW-NSGQVIAYLVLGVLLFIFSLVY 305
Cdd:cd17320 210 ---LGLSFAGL-FAYlAAAPFIYIEQLGLSPAQFGLLF 243
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
56-211 |
6.59e-10 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 61.05 E-value: 6.59e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 56 IVGTIIDVVAEQFGNHSKTGWL-VTGYSLPNAILSLIWGRFASIIGFQHSLILAILIFEAGSLIAALASSMNMLIVgrvv 134
Cdd:cd17323 17 IYSPALPQIAEDFHVSEEVANLgVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLII---- 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 135 agvggsgLQTLCFVIGCT-----------MVGERSRPLVISILSCAFAVAAIVGPIIGGAFTTHVTWRWCFYINLPIGGL 203
Cdd:cd17323 93 -------LRFLQGFFGSSplaigagtiadLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGF 165
|
....*...
gi 1095459775 204 AIIMFLLT 211
Cdd:cd17323 166 CLILIFLF 173
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
257-496 |
1.75e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 56.83 E-value: 1.75e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 257 FFGFALCSAGLVLFLLGLTFGGNKYSwnsGQVIAYLVLGVLLFIFSLVYDFFLFDKFNPEPDNISYRPLLlRRLVAKPAI 336
Cdd:COG2211 155 FAGLGGLLASVLPPPLVAAFGGDAAL---GYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKESL-KALLKNRPF 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 337 IIVNMVTFLLCTGYNGQMIYSVQFFQLIFASSAWKAGLHLIPIVITNVIAAIASGVITKKLGLvKPLLIFGGVLGVIGAG 416
Cdd:COG2211 231 LLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGK-KKAFIIGLLLAALGLL 309
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 417 LMTLMTNTSTKSTQIGVLLLpGFSLG------FALQASLMSAQLQITKDRPEAAmdfieVTAFNTFMKSLGTTLGGVLST 490
Cdd:COG2211 310 LLFFLGPGNLWLLLVLAALA-GIGLGailvlpWAMLADVVDYDEWKTGRRREGL-----YFGIFTFAIKLGQALAGALAG 383
|
....*.
gi 1095459775 491 TVFSAS 496
Cdd:COG2211 384 LLLALF 389
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
41-212 |
3.71e-08 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 55.73 E-value: 3.71e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 41 ASLTLVLFITALDILIVGTIIDVVAEQFG-NHSKTGWLVTGYSLPNAILSLIWGRFASIIGFQHSLILAILIFEAGSLIA 119
Cdd:cd17476 1 ATISGAQLLNQAGLGSVIVILPIIGDSFGtSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 120 ALASSMNMLIVG-RVVAGVGGSGLQTLCFVIGCTMVGERSRPLVISILSCAFAVAAIVGPIIGGAFTTHVTWRWCFYINl 198
Cdd:cd17476 81 GFSPNFIFFIICrALQGLGPAFLLPNAMALLGRTYPPGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFL- 159
|
170
....*....|....
gi 1095459775 199 piGGLAIIMFLLTY 212
Cdd:cd17476 160 --AILAAIVAVAAI 171
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
76-496 |
4.42e-08 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 55.89 E-value: 4.42e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 76 WLVTGYSLPNAILSLIWGRFASIIGFQHSLILAILIFEAGSLIAALASSMNMLIVGRVVAGVGGSGL--QTLCfVIGCTM 153
Cdd:PRK14995 45 WIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLIATRALLAIGAAMIvpATLA-GIRATF 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 154 VGERSRPLVISILSCAFAVAAIVGPIIGGAFTTHVTWRWCFYINLPIgGLAIIMFLLTYKAENKGILQQIKDaigtissf 233
Cdd:PRK14995 124 TEEKQRNMALGVWAAVGSGGAAFGPLVGGILLEHFYWGSVFLINVPI-VLVVMGLTARYVPRQAGRRDQPLN-------- 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 234 tfskfrhqvnfkrlmngiifkfdfFGFALCsagLVLFLLGLTFGGNkySWNSGQVIAYLVLGVLLFIFSLVYDFFLFDKf 313
Cdd:PRK14995 195 ------------------------LGHALM---LIVAILLLVYSAK--TALKGFLSLWVTSLTLLTGALLLGLFIRTQL- 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 314 npepdnISYRPLLLRRLVAKPAI---IIVNMVTFLLCTGYNGQMIYSVQFfqlIFASSAWKAGLHLIPIVITNVIAAIAS 390
Cdd:PRK14995 245 ------AASRPMIDMRLFTHRIIlsgVVMAMTAMITLVGFELLMAQELQF---VHGLSPLEAGMFMLPVMVASGFSGPIA 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 391 GVITKKLGLvKPLLIFGgvLGVIGAGLMTL-MTNTSTKSTQI-GVLLLPGFSLGFALQASlMSAQLQITKDRPEAAMDFI 468
Cdd:PRK14995 316 GILVSRLGL-RLVATGG--MALSALSFYGLaMTDFSTQQWQAwGLMALLGFSAASALLAS-TSAIMAAAPPEKAAAAGAI 391
|
410 420
....*....|....*....|....*...
gi 1095459775 469 EVTAFNtFMKSLGTTLGGVLSTTVFSAS 496
Cdd:PRK14995 392 ETMAYE-LGAGLGIAIFGLLLSRSYSAS 418
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
40-209 |
1.10e-06 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 51.03 E-value: 1.10e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 40 LASLTLVLFITALDILIVGTIIDVVAEQFG-NHSKTGWLVTGYSLPNAILSLIWGRFASIIGFQHSLILAILIFEAGSLI 118
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVDPILPAIAEALGaSPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 119 AALASSMNMLIVGRVVAGVGGSGLqtlcFVIGCTMVG----ERSRPLVISILSCAFAVAAIVGPIIGGAFTTHVtWRWCF 194
Cdd:cd17474 81 CGLSDSFALLLAGRALQGIGAAGL----GPLALTLIGdlfeGGERAKAMGLYEAALGLGIAVGPLLGGLLAAIS-WRYPF 155
|
170
....*....|....*...
gi 1095459775 195 YINL---PIGGLAIIMFL 209
Cdd:cd17474 156 FLLAaliPVAFLAILFLL 173
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
28-210 |
2.17e-06 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 50.05 E-value: 2.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 28 NDSPMGLSLYLCLASLTLVLFITALDILIVGTIIDVVAEQFG-NHSKTGWLVTGYSLPNAILSLIWGRFASIIGFQHSLI 106
Cdd:TIGR00895 7 RKQPLSRYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGlDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 107 LAILIFEAGSLIAALASSMNMLIVGRVVAGVGGSGLQTLCFVIGCTMVGERSRPLVISILSCAFAVAAIVGPIIGGAFTT 186
Cdd:TIGR00895 87 WSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIP 166
|
170 180
....*....|....*....|....*.
gi 1095459775 187 HVTWRWCFYIN--LPIGGLAIIMFLL 210
Cdd:TIGR00895 167 VFGWRSLFYVGgiAPLLLLLLLMRFL 192
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
40-230 |
2.94e-06 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 49.88 E-value: 2.94e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 40 LASLTLVLFITALDILIVGTIIDVVAEQFG-NHSKTGWLVTGYSLPNAILSLIWGRFASIIGFQHSLILAILIFEAGSLI 118
Cdd:COG2223 7 LLLATLAFFLAFGVWYLWSVLAPPLAEEFGlSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 119 AALASSMNMLIVGRVVAGVGGSGLqtlcFVIGCTMVGE----RSRPLVISILSCAFAVAAIVGPIIGGAFTTHVTWRWCF 194
Cdd:COG2223 87 LALAVSYWLLLLLGLLLGIGGGGS----FAVGIALVSKwfppDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162
|
170 180 190
....*....|....*....|....*....|....*.
gi 1095459775 195 YINLPIGGLAIIMFLLTYKAENKGILQQIKDAIGTI 230
Cdd:COG2223 163 LILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQ 198
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
48-383 |
3.23e-06 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 49.73 E-value: 3.23e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 48 FITALDILIVGTIIDVVAEQFGN-----HSktgwLVTGYSLPNAILSLIWGRFASIIGFQHSLILAILIFEAGSLIAALA 122
Cdd:PRK10504 20 FMQSLDTTIVNTALPSMAQSLGEsplhmHM----VIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALS 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 123 SSMNMLIVGRVVAGvggsglqtlcfvIGCTMVGERSRPLVISILSCAFAVAA------------IVGPIIGGAFTTHVTW 190
Cdd:PRK10504 96 GTLNELLLARVLQG------------VGGAMMVPVGRLTVMKIVPREQYMAAmtfvtlpgqvgpLLGPALGGLLVEYASW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 191 RWCFYINLP---IGGLAIIMFLLTYKAENKgilqqikdaigtissftfskfrhqvnfkrlmngiifKFDFFGFALCSAGL 267
Cdd:PRK10504 164 HWIFLINIPvgiIGAIATLMLMPNYTMQTR------------------------------------RFDLSGFLLLAVGM 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 268 VLFLLGLTfgGNKYSWNSGQVIAYLVLGVLLFIFSlvydFFLFDKFNPEP-------DNISYRPLLLRRLVAKpaiIIVN 340
Cdd:PRK10504 208 ATLTLALD--GSKGLGLSPLAIAGLVAVGVVALLL----YLLHARNNNRAlfslklfRTRTFSLGLAGSFAGR---IGSG 278
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1095459775 341 MVTFLlctgyngqmiySVQFFQLIFASSAWKAGLHLIPIVITN 383
Cdd:PRK10504 279 MLPFM-----------TPVFLQIGLGFSPFHAGLMMIPMVLGS 310
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
40-211 |
5.48e-06 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 48.75 E-value: 5.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 40 LASLTLVLFITALDILIVGTIIDVVAEQFGNHSKTGWLVTGYSLPNA---ILSLIWGRFASIIGFQHSLILAILIFEAGS 116
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSLGLSLLQTGLLFAAGFLgrpIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 117 LIAALASSMNMLIVGRVVAGVGGSGLQTLCFVIGCTMVGERSRPLVISILSCAFAVAAIVGPIIGGAFTTHVT----WRW 192
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSgdwgWRI 160
|
170
....*....|....*....
gi 1095459775 193 CFYINLPIGGLAIIMFLLT 211
Cdd:cd17316 161 LFLIGALPALLALLLRRRT 179
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
43-212 |
1.34e-05 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 47.57 E-value: 1.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 43 LTLVLFITALDILIVGTIIDVVAEQFGNHSKT----GWLVTGYSLPNAILSLIWGRFASIIGFQHSLILAILIFEAGSLI 118
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPFYVREFNKLGASgyyvGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 119 AALASSMNMLIVGRVVAGVGGSGLqTLCFVIGCTMVGERSRPLVISILSCAFAVAAIVGPIIGGAFTTHVTWRWCFYInl 198
Cdd:cd17330 81 LGLSRNLWLLFLARFLDGLTGGNV-SVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLV-- 157
|
170
....*....|....
gi 1095459775 199 pIGGLAIIMFLLTY 212
Cdd:cd17330 158 -AAALALLNLVLVL 170
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
72-217 |
3.03e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 46.40 E-value: 3.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 72 SKTGWLVTGYSLPNAILSLIWGRFASIIGFQHSLILAI--LIFEAGSLIAALASSMNMLIVGRVVAGVGGSGLQTLCFVI 149
Cdd:COG2271 216 AQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIglLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWAL 295
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1095459775 150 GCTMVGERSRPLVISILSCAFAVAAIVGPIIGGAFTTHVTWRWCFYINLPIGGLAIIMFLLTYKAENK 217
Cdd:COG2271 296 AAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
79-207 |
3.18e-05 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 46.61 E-value: 3.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 79 TGYSLPNAILSLIWGRFASIIGFQHSLILAILIFEAGSLIAALASSMNMLIVGRVVAGVGGsglqTLCFVIGCTMV---- 154
Cdd:TIGR00710 47 TLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGA----SAGSVISQALVrdiy 122
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1095459775 155 --GERSRplVISILSCAFAVAAIVGPIIGGAFTTHVTWRWCFYINLPIGGLAIIM 207
Cdd:TIGR00710 123 pgEELSR--IYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSAL 175
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
18-210 |
1.91e-04 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 44.09 E-value: 1.91e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 18 SDASLNARGSNDSPMGLSLYLCLASLTLVLFITAldiliVGTIIDVVAEQFG-NHSKTGWLVTGYSLPNAILSLIWGRFA 96
Cdd:COG2807 3 TTSSSARRSRRAGRWLLLLAIVLVALNLRPAITS-----VGPLLPEIRADLGlSATQAGLLTTLPLLAFGLFAPLAPRLA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 97 SIIGFQHSLILAILIFEAGSLIAALASSMNMLIVGRVVAGVGGsglqTLCFVIGCTMVGE---RSRPLVISILSCAFAVA 173
Cdd:COG2807 78 RRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGI----AVGNVLLPGLIKRwfpDRVGLMTGLYTAAMGLG 153
|
170 180 190
....*....|....*....|....*....|....*..
gi 1095459775 174 AIVGPIIGGAFTTHVTWRWCFYInlpIGGLAIIMFLL 210
Cdd:COG2807 154 AALAAGLTVPLAAALGWRGALAV---WALLALLALLL 187
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
79-266 |
6.77e-04 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 42.21 E-value: 6.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 79 TGYSLPNAILSLIWGRFASIIGFQHSLILAILIFEAGSLIAALASSMNMLIvgrvvagvGGSGLQTLC-----FVIGCTM 153
Cdd:PRK11102 33 SAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLI--------YMRFLHGLAaaaasVVINALM 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 154 -----VGERSRplVISILSCAFAVAAIVGPIIGGAFTTHVTWRWCFYInlpIGGLAIIMFLL-------TYKAENKgilq 221
Cdd:PRK11102 105 rdmfpKEEFSR--MMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWV---LALAAILAAALvfffipeTLPKERR---- 175
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 1095459775 222 qIKDAIGTISSFTFSKFRHQVNFkrlmnGIIFK--FDFFG-FALCSAG 266
Cdd:PRK11102 176 -QPFHLRTTIRNFASLFRHKRVL-----GYMLAsgFSFAGmFSFLTAG 217
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
40-210 |
8.73e-04 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 41.79 E-value: 8.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 40 LASLTLVLFITALDILIVGTIIDVVAEQFGNHSKT--GWLVTGYSLPNAILSLIWGRFASIIGFQHSLILAILIFEAGSL 117
Cdd:cd17473 1 LITLLLASTLTVMAGAAIAPALPAIAQHFVPNSELlvPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 118 IAALASSMNMLIVGRVVAGVGGSGLQTLCFvigcTMVG------ERSRplVISILSCAFAVAAIVGPIIGGAFTThVTWR 191
Cdd:cd17473 81 AGLFLDSLYALLASRALLGIGVAGIMTLAT----ALIGdyfegeERAK--MLGLQSAAMSLGGVVFLLLGGALAE-IGWR 153
|
170
....*....|....*....
gi 1095459775 192 WCFYINLpiggLAIIMFLL 210
Cdd:cd17473 154 APFLVYL----LALPVLIL 168
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
40-213 |
8.77e-04 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 41.79 E-value: 8.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 40 LASLTLVLFITALDILIVGTIIDVVAEQFG-NHSKTGWLVTGYSLPNAILSLIWGRFASIIGFQHSLILAILIFEAGSLI 118
Cdd:cd17319 5 IPLLFLAYVINYLDRVNISVAAPTIMKDLGlSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTAL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 119 AALASSMNMLIVGRVVAGVGGSGLQTLCFVIGCTMVGERSRPLVISILSCAFAVAAIVGPIIGGAFTTHVTWRWCFYInl 198
Cdd:cd17319 85 TGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFII-- 162
|
170
....*....|....*
gi 1095459775 199 pIGGLAIIMFLLTYK 213
Cdd:cd17319 163 -EGLLGLLLAVLWWF 176
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
40-210 |
8.94e-04 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 41.80 E-value: 8.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 40 LASLTLVLFITALDILIVGTIIDVVAEQFG-NHSKTGWLVTGYSLPNAILSLIWGRFASIIGFQHSLILAILIFEAGSLI 118
Cdd:cd17365 1 LALCFLIIVLDGFDLAVMGFVAPALAQDWGlSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 119 AALASSMNMLIVGRVVAGVGGSGLQTLCFVIGCTMVGERSRPLVISILSCAFAVAAIVGPIIGGAFTTHVTWRWCFYINl 198
Cdd:cd17365 81 TAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLG- 159
|
170
....*....|..
gi 1095459775 199 piGGLAIIMFLL 210
Cdd:cd17365 160 --GVPPLILLPL 169
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
83-210 |
2.51e-03 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 40.33 E-value: 2.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 83 LPNAILSliwGRFASIIGFQHSLILAILIFEAGSLIAALASSMNMLIVGRVVAGV----GGSGLQTLCfvigCTMVGERS 158
Cdd:PRK11551 64 LPGALLG---GRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVglggALPNLIALT----SEAVGPRL 136
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1095459775 159 RPLVISILSCAFAVAAIVGPIIGGAFTTHVTWRWCFYinlpIGGLA--IIMFLL 210
Cdd:PRK11551 137 RGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFY----VGGVGplLLVPLL 186
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
31-211 |
6.61e-03 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 39.04 E-value: 6.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 31 PMGLSLYLCLASLTlvlfitalDILIVGTIIDVVAEQFGNHSKTGWLVTGYSLPNAILSLIWGRFASIIGFQHSLILAIL 110
Cdd:PRK15403 18 PMALILYDFAAYLT--------TDLIQPGIINVVRDFNADVSLAPASVSLYLAGGMALQWLLGPLSDRIGRRPVLITGAL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1095459775 111 IFEAGSLIAALASSMNMLIVGRVVAGVGGSGLQTLCFVIGCTMVGERSRPLVISILSCAFAVAAIVGPIIGGAFTTHVTW 190
Cdd:PRK15403 90 IFTLACAATLFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLVAPIIGPLSGAALMHFVHW 169
|
170 180
....*....|....*....|.
gi 1095459775 191 RWCFYINLPIGGLAIIMFLLT 211
Cdd:PRK15403 170 KVLFAIIAVMGLIAFVGLLLA 190
|
|
| |
