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Conserved domains on  [gi|768753362|gb|AJU78012|]
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Rba50p [Saccharomyces cerevisiae YJM981]

Protein Classification

RPAP1 family protein( domain architecture ID 10554390)

RPAP1 family protein similar to human RNA polymerase II-associated protein 1 (RPAP1) that is required for interaction of the RNA polymerase II complex with acetylated histone H3

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RPAP1_C pfam08620
RPAP1-like, C-terminal; Inhibition of RPAP1 synthesis in Saccharomyces cerevisiae results in ...
 289-357 6.83e-41

RPAP1-like, C-terminal; Inhibition of RPAP1 synthesis in Saccharomyces cerevisiae results in changes in global gene expression that are similar to those caused by the loss of the RNAPII subunit Rpb11. This entry represents the C-terminal region that contains the motif GLHHH. This region is conserved from yeast to humans.


:

Pssm-ID: 462538  Cd Length: 69  Bit Score: 139.98  E-value: 6.83e-41
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 768753362  289 ECRFDFNGDLVPPTRQIDSTIHSGLHHHSDSPELAGYTIVELEHLARSTFPSQRCIAIQTLGRILYKLG 357
Cdd:pfam08620   1 ELRFDFKGNLIPPSESSDIPTHLGLHHHGDDPEAAGYTLPELAHLSRSTVPAQRCIALQTLGRILYKLG 69
RPAP1_N pfam08621
RPAP1-like, N-terminal; Inhibition of RPAP1 synthesis in Saccharomyces cerevisiae results in ...
 79-124 1.29e-14

RPAP1-like, N-terminal; Inhibition of RPAP1 synthesis in Saccharomyces cerevisiae results in changes in global gene expression that are similar to those caused by the loss of the RNAPII subunit Rpb11. This entry represents the N-terminal region of RPAP-1 that is conserved from yeast to humans.


:

Pssm-ID: 462539 [Multi-domain]  Cd Length: 46  Bit Score: 67.54  E-value: 1.29e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 768753362   79 KSIHNENIKVLQGMSDEQIVQEREDLYNSLDPKLIAKLLKNINKRA 124
Cdd:pfam08621   1 QRIDEENRARLASMSPEEIEEEREELLESLDPKLLEFLLKRANKKE 46
235kDa-fam super family cl31124
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 62-289 7.34e-04

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


The actual alignment was detected with superfamily member TIGR01612:

Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 42.35  E-value: 7.34e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768753362    62 KDAEKQQTSTDAPLSEAKSIHNENIKVLQGMSDEQIVQEREDLYNSLDPKliAKLLKNINKRAKDEN-NTP--------- 131
Cdd:TIGR01612  975 KINELDKAFKDASLNDYEAKNNELIKYFNDLKANLGKNKENMLYHQFDEK--EKATNDIEQKIEDANkNIPnieiaihts 1052

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768753362   132 ---LFAEIEGASGTWVGGNKQGIYDLPPLDDENVDvalEIRPKLgkdtKHVQFEEAGKEKDVEEEAKTNDDVDDIAPLDf 208
Cdd:TIGR01612 1053 iynIIDEIEKEIGKNIELLNKEILEEAEINITNFN---EIKEKL----KHYNFDDFGKEENIKYADEINKIKDDIKNLD- 1124

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768753362   209 qmaQCIDHMKNEelfkdVHFIKEESQNEINLEKLDINDpnFNDKLHEKYFPDLPKEVNKlKWMQPVQQKTDKNYIIEDVS 288
Cdd:TIGR01612 1125 ---QKIDHHIKA-----LEEIKKKSENYIDEIKAQIND--LEDVADKAISNDDPEEIEK-KIENIVTKIDKKKNIYDEIK 1193


                   .
gi 768753362   289 E 289
Cdd:TIGR01612 1194 K 1194
 
Name Accession Description Interval E-value
RPAP1_C pfam08620
RPAP1-like, C-terminal; Inhibition of RPAP1 synthesis in Saccharomyces cerevisiae results in ...
 289-357 6.83e-41

RPAP1-like, C-terminal; Inhibition of RPAP1 synthesis in Saccharomyces cerevisiae results in changes in global gene expression that are similar to those caused by the loss of the RNAPII subunit Rpb11. This entry represents the C-terminal region that contains the motif GLHHH. This region is conserved from yeast to humans.


Pssm-ID: 462538  Cd Length: 69  Bit Score: 139.98  E-value: 6.83e-41
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 768753362  289 ECRFDFNGDLVPPTRQIDSTIHSGLHHHSDSPELAGYTIVELEHLARSTFPSQRCIAIQTLGRILYKLG 357
Cdd:pfam08620   1 ELRFDFKGNLIPPSESSDIPTHLGLHHHGDDPEAAGYTLPELAHLSRSTVPAQRCIALQTLGRILYKLG 69
RPAP1_N pfam08621
RPAP1-like, N-terminal; Inhibition of RPAP1 synthesis in Saccharomyces cerevisiae results in ...
 79-124 1.29e-14

RPAP1-like, N-terminal; Inhibition of RPAP1 synthesis in Saccharomyces cerevisiae results in changes in global gene expression that are similar to those caused by the loss of the RNAPII subunit Rpb11. This entry represents the N-terminal region of RPAP-1 that is conserved from yeast to humans.


Pssm-ID: 462539 [Multi-domain]  Cd Length: 46  Bit Score: 67.54  E-value: 1.29e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 768753362   79 KSIHNENIKVLQGMSDEQIVQEREDLYNSLDPKLIAKLLKNINKRA 124
Cdd:pfam08621   1 QRIDEENRARLASMSPEEIEEEREELLESLDPKLLEFLLKRANKKE 46
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 62-289 7.34e-04

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 42.35  E-value: 7.34e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768753362    62 KDAEKQQTSTDAPLSEAKSIHNENIKVLQGMSDEQIVQEREDLYNSLDPKliAKLLKNINKRAKDEN-NTP--------- 131
Cdd:TIGR01612  975 KINELDKAFKDASLNDYEAKNNELIKYFNDLKANLGKNKENMLYHQFDEK--EKATNDIEQKIEDANkNIPnieiaihts 1052

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768753362   132 ---LFAEIEGASGTWVGGNKQGIYDLPPLDDENVDvalEIRPKLgkdtKHVQFEEAGKEKDVEEEAKTNDDVDDIAPLDf 208
Cdd:TIGR01612 1053 iynIIDEIEKEIGKNIELLNKEILEEAEINITNFN---EIKEKL----KHYNFDDFGKEENIKYADEINKIKDDIKNLD- 1124

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768753362   209 qmaQCIDHMKNEelfkdVHFIKEESQNEINLEKLDINDpnFNDKLHEKYFPDLPKEVNKlKWMQPVQQKTDKNYIIEDVS 288
Cdd:TIGR01612 1125 ---QKIDHHIKA-----LEEIKKKSENYIDEIKAQIND--LEDVADKAISNDDPEEIEK-KIENIVTKIDKKKNIYDEIK 1193


                   .
gi 768753362   289 E 289
Cdd:TIGR01612 1194 K 1194
 
Name Accession Description Interval E-value
RPAP1_C pfam08620
RPAP1-like, C-terminal; Inhibition of RPAP1 synthesis in Saccharomyces cerevisiae results in ...
 289-357 6.83e-41

RPAP1-like, C-terminal; Inhibition of RPAP1 synthesis in Saccharomyces cerevisiae results in changes in global gene expression that are similar to those caused by the loss of the RNAPII subunit Rpb11. This entry represents the C-terminal region that contains the motif GLHHH. This region is conserved from yeast to humans.


Pssm-ID: 462538  Cd Length: 69  Bit Score: 139.98  E-value: 6.83e-41
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 768753362  289 ECRFDFNGDLVPPTRQIDSTIHSGLHHHSDSPELAGYTIVELEHLARSTFPSQRCIAIQTLGRILYKLG 357
Cdd:pfam08620   1 ELRFDFKGNLIPPSESSDIPTHLGLHHHGDDPEAAGYTLPELAHLSRSTVPAQRCIALQTLGRILYKLG 69
RPAP1_N pfam08621
RPAP1-like, N-terminal; Inhibition of RPAP1 synthesis in Saccharomyces cerevisiae results in ...
 79-124 1.29e-14

RPAP1-like, N-terminal; Inhibition of RPAP1 synthesis in Saccharomyces cerevisiae results in changes in global gene expression that are similar to those caused by the loss of the RNAPII subunit Rpb11. This entry represents the N-terminal region of RPAP-1 that is conserved from yeast to humans.


Pssm-ID: 462539 [Multi-domain]  Cd Length: 46  Bit Score: 67.54  E-value: 1.29e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 768753362   79 KSIHNENIKVLQGMSDEQIVQEREDLYNSLDPKLIAKLLKNINKRA 124
Cdd:pfam08621   1 QRIDEENRARLASMSPEEIEEEREELLESLDPKLLEFLLKRANKKE 46
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 62-289 7.34e-04

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 42.35  E-value: 7.34e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768753362    62 KDAEKQQTSTDAPLSEAKSIHNENIKVLQGMSDEQIVQEREDLYNSLDPKliAKLLKNINKRAKDEN-NTP--------- 131
Cdd:TIGR01612  975 KINELDKAFKDASLNDYEAKNNELIKYFNDLKANLGKNKENMLYHQFDEK--EKATNDIEQKIEDANkNIPnieiaihts 1052

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768753362   132 ---LFAEIEGASGTWVGGNKQGIYDLPPLDDENVDvalEIRPKLgkdtKHVQFEEAGKEKDVEEEAKTNDDVDDIAPLDf 208
Cdd:TIGR01612 1053 iynIIDEIEKEIGKNIELLNKEILEEAEINITNFN---EIKEKL----KHYNFDDFGKEENIKYADEINKIKDDIKNLD- 1124

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768753362   209 qmaQCIDHMKNEelfkdVHFIKEESQNEINLEKLDINDpnFNDKLHEKYFPDLPKEVNKlKWMQPVQQKTDKNYIIEDVS 288
Cdd:TIGR01612 1125 ---QKIDHHIKA-----LEEIKKKSENYIDEIKAQIND--LEDVADKAISNDDPEEIEK-KIENIVTKIDKKKNIYDEIK 1193


                   .
gi 768753362   289 E 289
Cdd:TIGR01612 1194 K 1194
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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