|
Name |
Accession |
Description |
Interval |
E-value |
| MetC |
COG0626 |
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; ... |
11-340 |
2.06e-140 |
|
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; Cystathionine beta-lyase/cystathionine gamma-synthase is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 440391 [Multi-domain] Cd Length: 389 Bit Score: 402.89 E-value: 2.06e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 11 GITTQLSVIGRNPDEQSGFVNPPLYKGSTIILKKLSDLEQR-----KGRFYGTAGSPTIDNLENAWTHLTGGAGTVLSAS 85
Cdd:COG0626 2 GPATRAVHAGRDPDPQTGAVSPPIYLTSTFVFPSAEALAARfageeGGYIYSRYGNPTRRALEEALAALEGGEAALAFAS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 86 GLGSISLALLALSKAGDHILMTDSVYVPTRMLCDGLLAKFGVETDYYDPSIGKDIEKLVKPNTTVIFLESPGSGTMEVQD 165
Cdd:COG0626 82 GMAAISAVLLALLKAGDHVVASDDLYGGTRRLLDKVLARFGIEVTFVDPTDLAAVEAAIRPNTKLVFLETPSNPTLEVVD 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 166 IPALVSVAKKHGIKTILDNTWATPLFFDAHAHGIDISVEAGTKYLGGHSDLLIGLASAN-EECWPLLRSTYDAMAMLPGA 244
Cdd:COG0626 162 IAAIAAIAHAAGALLVVDNTFATPLLQRPLELGADIVVHSATKYLGGHSDVLGGAVVGRdEELAERLRFLQNALGAVLSP 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 245 EDCQLALRGMRTLHLRLKEVERKALDLAAWLGNRDEVEKVLHPAFEDCPGHEYWVRDYKGSSGLFSIVLKNGftRAGLEK 324
Cdd:COG0626 242 FDAWLLLRGLKTLALRMERHCENALAVAEWLEAHPAVARVYYPGLPSHPGHELAKRQMSGFGGMLSFELKGG--REAARR 319
|
330
....*....|....*.
gi 768801298 325 MVEGMKVLQLGFSWGG 340
Cdd:COG0626 320 FLDALKLFTLAVSLGG 335
|
|
| PRK09028 |
PRK09028 |
cystathionine beta-lyase; Provisional |
11-340 |
4.66e-135 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181615 [Multi-domain] Cd Length: 394 Bit Score: 389.48 E-value: 4.66e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 11 GITTQLSVIGRNPDEQSGFVNPPLYKGSTIILKKLSDLEQ------RKGRFYGTAGSPTIDNLENAWTHLTGGAGTVLSA 84
Cdd:PRK09028 4 KKATKIVSAGRDKKWTKGVINPPVFRASTVVFDTVAEMRHaaknraNGEMFYGRRGTPTHFAFQAAIVELEGGAGTALYP 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 85 SGLGSISLALLALSKAGDHILMTDSVYVPTRMLCDGLLAKFGVETDYYDPSIGKDIEKLVKPNTTVIFLESPGSGTMEVQ 164
Cdd:PRK09028 84 SGAAAISNALLSFLKAGDHLLMVDSCYEPTRDLCDKILKGFGIETTYYDPMIGEGIRELIRPNTKVLFLESPGSITMEVQ 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 165 DIPALVSVAKKHGIKTILDNTWATPLFFDAHAHGIDISVEAGTKYLGGHSDLLIGLASANEECWPLLRSTYDAMAMLPGA 244
Cdd:PRK09028 164 DVPTLSRIAHEHDIVVMLDNTWASPINSRPFEMGVDISIQAATKYIVGHSDVMLGTATANEKHWDQLREHSYLMGQCTSP 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 245 EDCQLALRGMRTLHLRLKEVERKALDLAAWLGNRDEVEKVLHPAFEDCPGHEYWVRDYKGSSGLFSIVLKNGFTRAgLEK 324
Cdd:PRK09028 244 DDVYLAMRGLRTLGVRLAQHEKNALKVANWLATRPEVDHVRHPAFETCPGHEFFKRDFSGSNGLFSFVLKQGDPKA-VTA 322
|
330
....*....|....*.
gi 768801298 325 MVEGMKVLQLGFSWGG 340
Cdd:PRK09028 323 LVEGMQHFKMGFSWGG 338
|
|
| PRK05967 |
PRK05967 |
cystathionine beta-lyase; Provisional |
1-340 |
4.57e-134 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 235657 [Multi-domain] Cd Length: 395 Bit Score: 387.24 E-value: 4.57e-134
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 1 MIDRTE-LSKFGITTQLSVIGRNPDEQSGFVNPPLYKGSTIILKKLSDLEQRKGRF-YGTAGSPTIDNLENAWTHLTGGA 78
Cdd:PRK05967 1 MAKKQLkTEKAGINTRLAHDGNDPGDYHGFVNPPVVHASTVLFPDAETMATRGQKYtYGTRGTPTTDALCKAIDALEGSA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 79 GTVLSASGLGSISLALLALSKAGDHILMTDSVYVPTRMLCDGLLAKFGVETDYYDPSIGKDIEKLVKPNTTVIFLESPGS 158
Cdd:PRK05967 81 GTILVPSGLAAVTVPFLGFLSPGDHALIVDSVYYPTRHFCDTMLKRLGVEVEYYDPEIGAGIAKLMRPNTKVVHTEAPGS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 159 GTMEVQDIPALVSVAKKHGIKTILDNTWATPLFFDAHAHGIDISVEAGTKYLGGHSDLLIGLASANEECWPLLRSTYDAM 238
Cdd:PRK05967 161 NTFEMQDIPAIAEAAHRHGAIVMMDNTWATPLYFRPLDFGVDISIHAATKYPSGHSDILLGTVSANEKCWPQLLEAHGTL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 239 AMLPGAEDCQLALRGMRTLHLRLKEVERKALDLAAWLGNRDEVEKVLHPAFEDCPGHEYWVRDYKGSSGLFSIVLKNGFT 318
Cdd:PRK05967 241 GLCAGPDDTYQILRGLRTMGIRLEHHRKSALEIARWLEGRPDVARVLHPALPSFPGHEIWKRDFSGASGIFSFVLAAGPE 320
|
330 340
....*....|....*....|....
gi 768801298 319 --RAGLEKMVEGMKVLQLGFSWGG 340
Cdd:PRK05967 321 kgKAKAHAFLDALEIFGLGYSWGG 344
|
|
| cysta_beta_ly_B |
TIGR01324 |
cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate ... |
14-340 |
2.56e-122 |
|
cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 130391 [Multi-domain] Cd Length: 377 Bit Score: 356.49 E-value: 2.56e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 14 TQLSVIGRNPDEQSGFVNPPLYKGSTIILKKLSDLEQRKGR-FYGTAGSPTIDNLENAWTHLTGGAGTVLSASGLGSISL 92
Cdd:TIGR01324 1 TRLIHSGRQPRFSQGSVNPPLQRASTVLFDSHAAQRRAKGElTYGRRGTLTHFALQDAMCELEGGAGCYLYPSGLAAVTN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 93 ALLALSKAGDHILMTDSVYVPTRMLCDGLLAKFGVETDYYDPSIGKDIEKLVKPNTTVIFLESPGSGTMEVQDIPALVSV 172
Cdd:TIGR01324 81 SILAFVKAGDHVLMVDSAYEPTRYFCDIVLKRMGVDITYYDPLIGEDIATLIQPNTKVLFLEAPSSITFEIQDIPAIAKA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 173 AKKHGIKTILDNTWATPLFFDAHAHGIDISVEAGTKYLGGHSDLLIGLASANEECWPLLRSTYDAMAMLPGAEDCQLALR 252
Cdd:TIGR01324 161 ARNPGIVIMIDNTWAAGLLFKPLEHGVDISIQAGTKYLVGHSDIMIGTVVANARTWDQLREHSYLMGQMVDADDAYTTLR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 253 GMRTLHLRLKEVERKALDLAAWLGNRDEVEKVLHPAFEDCPGHEYWVRDYKGSSGLFSIVLKNGfTRAGLEKMVEGMKVL 332
Cdd:TIGR01324 241 GLRTLGVRLKQHQESSLAIAKWLSEQPEVARVLHPALPSCPGHEFWKRDFSGSSGLFSFVLQRL-TQKQVHAFLDHLQLF 319
|
....*...
gi 768801298 333 QLGFSWGG 340
Cdd:TIGR01324 320 GLGYSWGG 327
|
|
| PRK07050 |
PRK07050 |
cystathionine beta-lyase; Provisional |
23-340 |
3.14e-121 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 180810 [Multi-domain] Cd Length: 394 Bit Score: 354.42 E-value: 3.14e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 23 PDEQ--SGF--VNPPLYKGSTIILKKLSDL-----EQRKGRFYGTAGSPTIDNLENAWTHLTGGAGTVLSASGLGSISLA 93
Cdd:PRK07050 17 PDDQipPGFrsFVTPVARASTVVFPDLATMraldwRQDVQWRYGLHATPTSLALAQRLAEIEGGRHALLQPSGLAAISLV 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 94 LLALSKAGDHILMTDSVYVPTRMLCDGLLAKFGVETDYYDPSIGKDIEKLVKPNTTVIFLESPGSGTMEVQDIPALVSVA 173
Cdd:PRK07050 97 YFGLVKAGDDVLIPDNAYGPNRDHGEWLARDFGITVRFYDPLIGAGIADLIQPNTRLIWLEAPGSVTMEVPDVPAITAAA 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 174 KKHGIKTILDNTWATPLFFDAHAHGIDISVEAGTKYLGGHSDLLIG-LASANEECWPLLRSTYDAMAMLPGAEDCQLALR 252
Cdd:PRK07050 177 RARGVVTAIDNTYSAGLAFKPFEHGVDISVQALTKYQSGGSDVLMGaTITADAELHAKLKLARMRLGIGVSADDCSLVLR 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 253 GMRTLHLRLKEVERKALDLAAWLGNRDEVEKVLHPAFEDCPGHEYWVRDYKGSSGLFSIVLKNGFTRAGLEKMVEGMKVL 332
Cdd:PRK07050 257 GLPSLQVRLAAHDRSALEVAEWLKARPEIATVLHPALPDCPGHAFWMRDFTGAGGLFSVVFDERYSPAQVDAFVEALELF 336
|
....*...
gi 768801298 333 QLGFSWGG 340
Cdd:PRK07050 337 AIGWSWGG 344
|
|
| PRK08114 |
PRK08114 |
cystathionine beta-lyase; Provisional |
7-340 |
5.74e-117 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181231 [Multi-domain] Cd Length: 395 Bit Score: 343.61 E-value: 5.74e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 7 LSKFGITTQLSVIGRNPDEQSGFVNPPLYKGSTIILKKLSDLEQ-RKGR-----FYGTAGSPTIDNLENAWTHLTGGAGT 80
Cdd:PRK08114 1 MTDKKLDTQLVNAGRSKKYTQGSVNSVIQRASSLVFDSVEAKKHaTRNRangelFYGRRGTLTHFSLQEAMCELEGGAGC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 81 VLSASGLGSISLALLALSKAGDHILMTDSVYVPTRMLCDGLLAKFGVETDYYDPSIGKDIEKLVKPNTTVIFLESPGSGT 160
Cdd:PRK08114 81 ALYPCGAAAVANAILAFVEQGDHVLMTGTAYEPTQDFCSKILSKLGVTTTWFDPLIGADIAKLIQPNTKVVFLESPGSIT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 161 MEVQDIPALVSVAKKHG--IKTILDNTWATPLFFDAHAHGIDISVEAGTKYLGGHSDLLIGLASANEECWPLLRSTYDAM 238
Cdd:PRK08114 161 MEVHDVPAIVAAVRSVNpdAVIMIDNTWAAGVLFKALDFGIDISIQAGTKYLVGHSDAMIGTAVANARCWEQLRENSYLM 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 239 AMLPGAEDCQLALRGMRTLHLRLKEVERKALDLAAWLGNRDEVEKVLHPAFEDCPGHEYWVRDYKGSSGLFSIVLKNGFT 318
Cdd:PRK08114 241 GQMVDADTAYMTSRGLRTLGVRLRQHEESSLKVAEWLAEHPEVARVNHPALPGCKGHEFWKRDFTGSSGLFSFVLKKKLT 320
|
330 340
....*....|....*....|..
gi 768801298 319 RAGLEKMVEGMKVLQLGFSWGG 340
Cdd:PRK08114 321 DEQLANYLDNFSLFSMAYSWGG 342
|
|
| Cys_Met_Meta_PP |
pfam01053 |
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and ... |
14-340 |
1.35e-107 |
|
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.
Pssm-ID: 395837 [Multi-domain] Cd Length: 376 Bit Score: 319.18 E-value: 1.35e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 14 TQLSVIGRNPDEQSGFVNPPLYKGSTIilkKLSDLEQRKGRFYGTAGSPTIDNLENAWTHLTGGAGTVLSASGLGSISLA 93
Cdd:pfam01053 2 TLAVHAGQRPDPQTGAVSVPIYLTSTY---VFDFAGEEGGYDYSRSGNPTRDVLEERIAALEGGAAALAFSSGMAAITAA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 94 LLALSKAGDHILMTDSVYVPTRMLCDGLLAKFGVETDYYDPSIGKDIEKLVKPNTTVIFLESPGSGTMEVQDIPALVSVA 173
Cdd:pfam01053 79 ILALLKAGDHIVATDDLYGGTYRLFNKVLPRFGIEVTFVDTSDPEDLEAAIKPNTKAVYLETPTNPLLKVVDIEAIAKLA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 174 KKHGIKTILDNTWATPLFFDAHAHGIDISVEAGTKYLGGHSDLLIGLASANEECWPL-LRSTYDAMAMLPGAEDCQLALR 252
Cdd:pfam01053 159 KKHGILVVVDNTFASPYLQRPLDLGADIVVHSATKYIGGHSDVVGGVIVVNGEELGKeLYFLQNATGAVLSPFDAWLLLR 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 253 GMRTLHLRLKEVERKALDLAAWLGNRDEVEKVLHPAFEDCPGHEYWVRDYKGSSGLFSIVLKNGFTRAglEKMVEGMKVL 332
Cdd:pfam01053 239 GLKTLGLRMEQHQENAQKVAEFLESHPKVEKVYYPGLPSHPGHELAKRQMKGFGGMLSFELKGGLEAA--KKFLDNLKLF 316
|
....*...
gi 768801298 333 QLGFSWGG 340
Cdd:pfam01053 317 SLAVSLGG 324
|
|
| CGS_like |
cd00614 |
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ... |
30-340 |
5.89e-99 |
|
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.
Pssm-ID: 99738 [Multi-domain] Cd Length: 369 Bit Score: 296.81 E-value: 5.89e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 30 VNPPLYKGSTIILKKLSDLEQRKGR-----FYGTAGSPTIDNLENAWTHLTGGAGTVLSASGLGSISLALLALSKAGDHI 104
Cdd:cd00614 3 VAPPIYQTSTFVFPSPAEAADLFALreggyIYSRIGNPTVDALEKKLAALEGGEAALAFSSGMAAISTVLLALLKAGDHV 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 105 LMTDSVYVPTRMLCDGLLAKFGVETDYYDPSIGKDIEKLVKPNTTVIFLESPGSGTMEVQDIPALVSVAKKHGIKTILDN 184
Cdd:cd00614 83 VASDDLYGGTYRLFERLLPKLGIEVTFVDPDDPEALEAAIKPETKLVYVESPTNPTLKVVDIEAIAELAHEHGALLVVDN 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 185 TWATPLFFDAHAHGIDISVEAGTKYLGGHSDLLIGLASAN-EECWPLLRSTYDAMAMLPGAEDCQLALRGMRTLHLRLKE 263
Cdd:cd00614 163 TFATPYLQRPLELGADIVVHSATKYIGGHSDVIAGVVVGSgEALIQRLRFLRLALGTILSPFDAWLLLRGLKTLPLRMER 242
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 768801298 264 VERKALDLAAWLGNRDEVEKVLHPAFEDCPGHEYWVRDYKGSSGLFSIVLKNGFTRAglEKMVEGMKVLQLGFSWGG 340
Cdd:cd00614 243 HSENALKVAEFLEKHPKVERVYYPGLPSHPQHELAKKQMSGYGGVFSFELKGGLEAA--KKFLNALKLFSLAVSLGG 317
|
|
| met_gam_lyase |
TIGR01328 |
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of ... |
20-340 |
2.15e-67 |
|
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of PLP-dependent trans-sulfuration enzymes. The member from the parasite Trichomonas vaginalis is described as catalyzing alpha gamma- and alpha-beta eliminations and gamma-replacement reactions on methionine, cysteine, and some derivatives. Likewise, the enzyme from Pseudomonas degrades cysteine as well as methionine. [Energy metabolism, Amino acids and amines]
Pssm-ID: 130395 [Multi-domain] Cd Length: 391 Bit Score: 216.68 E-value: 2.15e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 20 GRNPDEQSGFVNPPLYKGSTIILKKLSD-----LEQRKGRFYGTAGSPTIDNLENAWTHLTGGAGTVLSASGLGSISLAL 94
Cdd:TIGR01328 12 GYPPKDQFGALTPPIYQTSTFVFDSCEQggnrfAGQESGYIYSRLGNPTVSNLEGRIAFLEGTEAAVATSSGMGAIAATL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 95 LALSKAGDHILMTDSVYVPTRMLCDGLLAKFGVETDYYDPSIGKDIEKLVKPNTTVIFLESPGSGTMEVQDIPALVSVAK 174
Cdd:TIGR01328 92 LTILKAGDHLISDECLYGCTFALLEHALTKFGIQVDFINMAIPEEVKAHIKDNTKIVYFETPANPTMKLIDMERVCRDAH 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 175 KHGIKTILDNTWATPLFFDAHAHGIDISVEAGTKYLGGHSDLLIGLASANEECWPLLRST--YDAMAMLPGAEDCQLALR 252
Cdd:TIGR01328 172 SQGVKVIVDNTFATPMLTNPVALGVDVVVHSATKYIGGHGDVVAGLICGKAELLQQIRMVgiKDMTGSVISPFDAWLILR 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 253 GMRTLHLRLKEVERKALDLAAWLGNRDEVEKVLHPAFEDCPGHEYWVRDYKGSSGLFSIVLKNGFtrAGLEKMVEGMKVL 332
Cdd:TIGR01328 252 GLKTLNIRMKRHSENAMKVAEYLKSHPAVEKVYYPGFEDHPGHDIAAKQMRMGGGMITFELKGGF--AGAKKLLNNLKLI 329
|
....*...
gi 768801298 333 QLGFSWGG 340
Cdd:TIGR01328 330 RLAVSLGD 337
|
|
| PRK05968 |
PRK05968 |
hypothetical protein; Provisional |
23-340 |
1.12e-64 |
|
hypothetical protein; Provisional
Pssm-ID: 168320 [Multi-domain] Cd Length: 389 Bit Score: 209.55 E-value: 1.12e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 23 PDEQSGF--VNPPLYKGSTIILKKLSDLEQ----RKGRFYGTAG-SPTIDNLENAWTHLTGGAGTVLSASGLGSISLALL 95
Cdd:PRK05968 17 HDEGNAFdaVVPPIFQTSLFTFDSYDEMEDvyagEKVRPIYSRGdNPTVRAFEEMLAKLEGAEDARGFASGMAAISSTVL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 96 ALSKAGDHILMTDSVYVPTRMLCDGLLAKFGVETDYYDPSIGKDIEKLVkPNTTVIFLESPGSGTMEVQDIPALVSVAKK 175
Cdd:PRK05968 97 SFVEPGDRIVAVRHVYPDAFRLFETILKRMGVEVDYVDGRDEEAVAKAL-PGAKLLYLESPTSWVFELQDVAALAALAKR 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 176 HGIKTILDNTWATPLFFDAHAHGIDISVEAGTKYLGGHSDLLIGL--------ASANEECWPLL---RSTYDAMamlpga 244
Cdd:PRK05968 176 HGVVTMIDNSWASPVFQRPITLGVDLVIHSASKYLGGHSDTVAGVvagskehiARINAEAYPYLgakLSPFEAW------ 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 245 edcqLALRGMRTLHLRLKEVERKALDLAAWLGNRDEVEKVLHPAFEDCPgheywVRDYKGSSGLFSIVLKNGFTragLEK 324
Cdd:PRK05968 250 ----LLLRGLRTLPLRMKAHEASALEIARRLKAHPVVERVCHPALANHP-----PAGLSGTSGLFSFIFREGID---VRA 317
|
330
....*....|....*.
gi 768801298 325 MVEGMKVLQLGFSWGG 340
Cdd:PRK05968 318 FADALKLFRLGVSWGG 333
|
|
| PRK07671 |
PRK07671 |
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase; |
20-311 |
1.66e-60 |
|
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase;
Pssm-ID: 181076 [Multi-domain] Cd Length: 377 Bit Score: 198.41 E-value: 1.66e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 20 GRNPDEQSGFVNPPLYKGSTIilkKLSDLEQRKGRFYGTAGSPTIDNLENAWTHLTGGAGTVLSASGLGSISlALLALSK 99
Cdd:PRK07671 11 GIIGDPSTGAVSVPIYQVSTY---KQEAVGKHQGYEYSRTGNPTRAALEELIAVLEGGHAGFAFGSGMAAIT-AVMMLFS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 100 AGDHILMTDSVYVPTRMLCDGLLAKFGVETDYYDPSIGKDIEKLVKPNTTVIFLESPGSGTMEVQDIPALVSVAKKHGIK 179
Cdd:PRK07671 87 SGDHVILTDDVYGGTYRVMTKVLNRFGIEHTFVDTSNLEEVEEAIRPNTKAIYVETPTNPLLKITDIKKISTIAKEKGLL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 180 TILDNTWATPLFFDAHAHGIDISVEAGTKYLGGHSDLLIGLASAN-EECWPLLRSTYDAMAMLPGAEDCQLALRGMRTLH 258
Cdd:PRK07671 167 TIVDNTFMTPYWQSPISLGADIVLHSATKYLGGHSDVVAGLVVVNsPELAEDLHFVQNSTGGILGPQDSWLLLRGLKTLG 246
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 768801298 259 LRLKEVERKALDLAAWLGNRDEVEKVLHPAFEDCPGHEYWVRDYKGSSGLFSI 311
Cdd:PRK07671 247 IRMEEHETNSRAIAEFLNNHPAVNKVYYPGLPSHPNHELAKEQANGFGGMISF 299
|
|
| PRK07811 |
PRK07811 |
cystathionine gamma-synthase; Provisional |
8-340 |
3.84e-60 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 236104 [Multi-domain] Cd Length: 388 Bit Score: 197.56 E-value: 3.84e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 8 SKFGITTQLSVIGRNPDEQSGFVNPPLYKGSTIILKKLSDLeqRKGRFYGTAGSPTIDNLENAWTHLTGGAGTVLSASGL 87
Cdd:PRK07811 9 ANQGFATRAIHAGYEPDPATGAVNPPIYASSTFAQDGVGGL--RGGYEYARTGNPTRTALEEQLAALEGGAYGRAFSSGM 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 88 GSISLALLALSKAGDHILMTDSVYVPTRMLCDGLLAKFGVETDYYDPSIGKDIEKLVKPNTTVIFLESPGSGTMEVQDIP 167
Cdd:PRK07811 87 AATDCLLRAVLRPGDHIVIPNDAYGGTFRLIDKVFTRWGVEYTPVDLSDLDAVRAAITPRTKLIWVETPTNPLLSITDIA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 168 ALVSVAKKHGIKTILDNTWATPLFFDAHAHGIDISVEAGTKYLGGHSDLLIG-LASANEECWPLLRSTYDAMAMLPGAED 246
Cdd:PRK07811 167 ALAELAHDAGAKVVVDNTFASPYLQQPLALGADVVVHSTTKYIGGHSDVVGGaLVTNDEELDEAFAFLQNGAGAVPGPFD 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 247 CQLALRGMRTLHLRLKEVERKALDLAAWLGNRDEVEKVLHPAFEDCPGHEYWVRDYKGSSGLFSIVLKNGFTRAglEKMV 326
Cdd:PRK07811 247 AYLTLRGLKTLAVRMDRHSENAEAVAEFLAGHPEVSTVLYPGLPSHPGHEVAARQMRGFGGMVSVRLAGGEEAA--RDFC 324
|
330
....*....|....
gi 768801298 327 EGMKVLQLGFSWGG 340
Cdd:PRK07811 325 ARTKVFTLAESLGG 338
|
|
| PRK08064 |
PRK08064 |
cystathionine beta-lyase MetC; |
24-339 |
8.42e-60 |
|
cystathionine beta-lyase MetC;
Pssm-ID: 236146 [Multi-domain] Cd Length: 390 Bit Score: 196.92 E-value: 8.42e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 24 DEQSGFVNPPLYKGSTIilkKLSDLEQRKGRFYGTAGSPTIDNLENAWTHLTGGAGTVLSASGLGSISLALLALSKaGDH 103
Cdd:PRK08064 19 DKQTGAVNVPIYHASTF---HQFDFDTFGKYDYSRSGNPTREALEDIIAELEGGTKGFAFASGMAAISTAFLLLSK-GDH 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 104 ILMTDSVYVPTRMLCDGLLAKFGVETDYYDPSIGKDIEKLVKPNTTVIFLESPGSGTMEVQDIPALVSVAKKHGIKTILD 183
Cdd:PRK08064 95 VLISEDVYGGTYRMITEVLSRFGIEHTFVDMTNLEEVAQNIKPNTKLFYVETPSNPLLKVTDIRGVVKLAKAIGCLTFVD 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 184 NTWATPLFFDAHAHGIDISVEAGTKYLGGHSDLLIGLASA-NEECWPLLRSTYDAMAMLPGAEDCQLALRGMRTLHLRLK 262
Cdd:PRK08064 175 NTFLTPLLQKPLDLGADVVLHSATKFLAGHSDVLAGLAVVkDEELAQKLYFLQNSFGAVLGVQDCWLVLRGLKTLHVRLE 254
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 768801298 263 EVERKALDLAAWLGNRDEVEKVLHPAFEDCPGHEYWVRDYKGSSGLFSIVLKNgftRAGLEKMVEGMKVLQLGFSWG 339
Cdd:PRK08064 255 HSSETANKIALYLQEHPKVQNVYYPGLQTHLGFDIQQSQATSAGAVLSFTLQS---EEAVRQFVSHVKLPVFAVSLG 328
|
|
| PRK06176 |
PRK06176 |
cystathionine gamma-synthase; |
20-340 |
4.17e-57 |
|
cystathionine gamma-synthase;
Pssm-ID: 180443 [Multi-domain] Cd Length: 380 Bit Score: 189.72 E-value: 4.17e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 20 GRNPDEQSGFVNPPLYKGSTIilkKLSDLEQRKGRFYGTAGSPTIDNLENAWTHLTGGAGTVLSASGLGSISlALLALSK 99
Cdd:PRK06176 11 GISEDTTTGAVSVPIYQTSTY---RQDAIGRPKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIH-AVFSLFQ 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 100 AGDHILMTDSVYVPTRMLCDGLLAKFGVETDYYDPSIGKDIEKLVKPNTTVIFLESPGSGTMEVQDIPALVSVAKKHGIK 179
Cdd:PRK06176 87 SGDHVLLGDDVYGGTFRLFDKVLVKNGLSCTIIDTSDLSQIKKAIKPNTKALYLETPSNPLLKITDLAQCASVAKDHGLL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 180 TILDNTWATPLFFDAHAHGIDISVEAGTKYLGGHSDLLIGLASAN-EECWPLLRSTYDAMAMLPGAEDCQLALRGMRTLH 258
Cdd:PRK06176 167 TIVDNTFATPYYQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNnEALAQEIAFFQNAIGGVLGPQDSWLLQRGIKTLG 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 259 LRLKEVERKALDLAAWLGNRDEVEKVLHPAFEDCPGHEYWVRDYKGSSGLFSIVLKNgftRAGLEKMVEGMKVLQLGFSW 338
Cdd:PRK06176 247 LRMEAHQKNALCVAEFLEKHPKVEKVYYPGLPTHPNHELAKKQMRGFSGMLSFTLKN---DSEAVAFVESLKLFILGESL 323
|
..
gi 768801298 339 GG 340
Cdd:PRK06176 324 GG 325
|
|
| PRK08247 |
PRK08247 |
methionine biosynthesis PLP-dependent protein; |
12-287 |
1.52e-52 |
|
methionine biosynthesis PLP-dependent protein;
Pssm-ID: 181320 [Multi-domain] Cd Length: 366 Bit Score: 177.20 E-value: 1.52e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 12 ITTQLSVIGRNPDEQSGFVNPPLYKgSTIIlkKLSDLEQRKGRFYGTAGSPTIDNLENAWTHLTGGAGTVLSASGLGSIS 91
Cdd:PRK08247 5 IETKLAQIGNRSDERTGTVNPPVYF-STAY--RHEGIGESTGFDYSRTGNPTRGVLEQAIADLEGGDQGFACSSGMAAIQ 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 92 LaLLALSKAGDHILMTDSVYVPTRMLCDGLLAKFGVETDYYDPSIGKDIEKLVKPNTTVIFLESPGSGTMEVQDIPALVS 171
Cdd:PRK08247 82 L-VMSLFRSGDELIVSSDLYGGTYRLFEEHWKKWNVRFVYVNTASLKAIEQAITPNTKAIFIETPTNPLMQETDIAAIAK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 172 VAKKHGIKTILDNTWATPLFFDAHAHGIDISVEAGTKYLGGHSDLLIGL--ASANEECWPLLRSTYDAMAMLPgAEDCQL 249
Cdd:PRK08247 161 IAKKHGLLLIVDNTFYTPVLQRPLEEGADIVIHSATKYLGGHNDVLAGLvvAKGQELCERLAYYQNAAGAVLS-PFDSWL 239
|
250 260 270
....*....|....*....|....*....|....*...
gi 768801298 250 ALRGMRTLHLRLKEVERKALDLAAWLGNRDEVEKVLHP 287
Cdd:PRK08247 240 LIRGMKTLALRMRQHEENAKAIAAFLNEQPGVTDVLYP 277
|
|
| PRK06234 |
PRK06234 |
methionine gamma-lyase; Provisional |
4-339 |
3.06e-52 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 168478 [Multi-domain] Cd Length: 400 Bit Score: 177.33 E-value: 3.06e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 4 RTELSKFGITTQLSVIGRNPDEQSGFVNPPLYKGSTIILkklSDLEQRKGRF--------YGTAGSPTIDNLENAWTHLT 75
Cdd:PRK06234 1 MENIKKMGFATKAIHGGHIGDKQFGSLATPIYQTSTFIF---DSAEQGGRRFageesgyiYSRLGNPTSTEVENKLALLE 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 76 GGAGTVLSASGLGSISLALLALSKAGDHILMTDSVYVPTRMLCDGLLAKFGVETDYYDPSIGKDIEKLVKPNTTVIFLES 155
Cdd:PRK06234 78 GGEAAVVAASGMGAISSSLWSALKAGDHVVASDTLYGCTFALLNHGLTRYGVEVTFVDTSNLEEVRNALKANTKVVYLET 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 156 PGSGTMEVQDIPALVSVAKKH--GIKTILDNTWATPLFFDAHAHGIDISVEAGTKYLGGHSDLLIGLASANEECWPLLR- 232
Cdd:PRK06234 158 PANPTLKVTDIKAISNIAHENnkECLVFVDNTFCTPYIQRPLQLGADVVVHSATKYLNGHGDVIAGFVVGKEEFINQVKl 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 233 -STYDAMAMLPGAEDCQLALRGMRTLHLRLKEVERKALDLAAWLGNRDEVEKVLHPAFEDCPGHEYWVRDYKGSSGLFSI 311
Cdd:PRK06234 238 fGIKDMTGSVIGPFEAFLIIRGMKTLQIRMEKHCKNAMKVAKFLESHPAVEKVYYPGLESFEYYELAKKQMSLPGAMISF 317
|
330 340
....*....|....*....|....*...
gi 768801298 312 VLKNGFtRAGlEKMVEGMKVLQLGFSWG 339
Cdd:PRK06234 318 ELKGGV-EEG-KVVMNNVKLATLAVSLG 343
|
|
| PRK06767 |
PRK06767 |
methionine gamma-lyase; Provisional |
20-339 |
8.14e-52 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 180685 [Multi-domain] Cd Length: 386 Bit Score: 175.80 E-value: 8.14e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 20 GRNPDEQSGFVNPPLYKGSTIilkKLSDLEQRKGRF--------YGTAGSPTIDNLENAWTHLTGGAGTVLSASGLGSIS 91
Cdd:PRK06767 14 GYTSEEHKGSLTPPLFQTSTF---TFETAQQGEASFagvdpsyiYSRLGNPTVKLFEERMAVLEGGEEALAFGSGMAAIS 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 92 LALLALSKAGDHILMTDSVYVPTRMLCDGLLAKFGVETDYYDPSIGKDIEKLVKPNTTVIFLESPGSGTMEVQDIPALVS 171
Cdd:PRK06767 91 ATLIGFLKAGDHIICSNGLYGCTYGFLEVLEEKFMITHSFCDMETEADIENKIRPNTKLIFVETPINPTMKLIDLKQVIR 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 172 VAKKHGIKTILDNTWATPLFFDAHAHGIDISVEAGTKYLGGHSDLLIGLASANEECWPLL-RSTYDAMAMLPGAEDCQLA 250
Cdd:PRK06767 171 VAKRNGLLVIVDNTFCSPYLQRPLELGCDAVVHSATKYIGGHGDVVAGVTICKTRALAEKiRPMRKDIGGIMAPFDAWLL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 251 LRGMRTLHLRLKEVERKALDLAAWLGNRDEVEKVLHPAfedcpgHEYWVRDYKGSSGLFSIVLKNGFTRAglEKMVEGMK 330
Cdd:PRK06767 251 LRGLKTLAVRMDRHCDNAEKIVSFLKNHDAVEGVWYPE------GELASRQMKRGGGVISFSIKGGKEET--QAFINDLH 322
|
....*....
gi 768801298 331 VLQLGFSWG 339
Cdd:PRK06767 323 FITIAVSLG 331
|
|
| OAH_OAS_sulfhy |
TIGR01326 |
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism ... |
20-330 |
1.07e-48 |
|
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism pyridoxal phosphate-dependent enzyme superfamily. Members include examples of OAH/OAS sulfhydrylase, an enzyme with activity both as O-acetylhomoserine (OAH) sulfhydrylase (EC 2.5.1.49) and O-acetylserine (OAS) sulphydrylase (EC 2.5.1.47). An alternate name for OAH sulfhydrylase is homocysteine synthase. This model is designated subfamily because it may or may not have both activities. [Amino acid biosynthesis, Aspartate family, Amino acid biosynthesis, Serine family]
Pssm-ID: 273555 [Multi-domain] Cd Length: 418 Bit Score: 168.69 E-value: 1.07e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 20 GRNPDEQSGFVNPPLYKGSTIILK------KLSDLEQrKGRFYGTAGSPTIDNLENAWTHLTGGAGTVLSASGLGSISLA 93
Cdd:TIGR01326 10 GQEPDPTTGSRAVPIYQTTSYVFDstehaaALFGLQE-PGNIYSRLMNPTTDVLEQRIAALEGGVAALAVASGQAAITYA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 94 LLALSKAGDHILMTDSVYVPTRMLCDGLLAKFGVETDYYDPSIGKDIEKLVKPNTTVIFLESPGSGTMEVQDIPALVSVA 173
Cdd:TIGR01326 89 ILNLAGAGDNIVSSSYLYGGTYNLFSHTLKRLGIEVRFVDPDDPESLEKAIDENTKAVFAETIGNPQINVLDIEAIAEVA 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 174 KKHGIKTILDNTWATPLFFDAHAHGIDISVEAGTKYLGGHSDLLIGLA------SANEECWP------------------ 229
Cdd:TIGR01326 169 HRHGIPLIVDNTFATPYLCRPIKHGADIVVHSATKYIGGHGTAIGGVIvdggkfDWNNGRFPlfttpdpsyhglvftetl 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 230 ------------LLRSTYDAMAmlpgAEDCQLALRGMRTLHLRLKEVERKALDLAAWLGNRDEVEKVLHPAFEDCPGHEY 297
Cdd:TIGR01326 249 gnpafilkarvqLLRDLGAALS----PFNAFLLLQGLETLSLRMERHVENALKVAEFLESHPDVAWVNYPGLASHPHHAL 324
|
330 340 350
....*....|....*....|....*....|....*
gi 768801298 298 wVRDY--KGSSGLFSIVLKNGftRAGLEKMVEGMK 330
Cdd:TIGR01326 325 -AKKYlpKGFGAVLSFEIKGG--REAGKKFIDALK 356
|
|
| PRK08133 |
PRK08133 |
O-succinylhomoserine sulfhydrylase; Validated |
50-332 |
1.20e-47 |
|
O-succinylhomoserine sulfhydrylase; Validated
Pssm-ID: 181244 [Multi-domain] Cd Length: 390 Bit Score: 165.17 E-value: 1.20e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 50 QRKGRFYGTAGSPTIDNLENAWTHLTGGAGTVLSASGLGSISLALLALSKAGDHILMTDSVYVPTRMLCDGLLAKFGVET 129
Cdd:PRK08133 49 EEPGNIYSRFTNPTVTMFQERLAALEGAEACVATASGMAAILAVVMALLQAGDHVVSSRSLFGSTVSLFEKIFARFGIET 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 130 DYYDPSIGKDIEKLVKPNTTVIFLESPGSGTMEVQDIPALVSVAKKHGIKTILDNTWATPLFFDAHAHGIDISVEAGTKY 209
Cdd:PRK08133 129 TFVDLTDLDAWRAAVRPNTKLFFLETPSNPLTELADIAALAEIAHAAGALLVVDNCFCTPALQQPLKLGADVVIHSATKY 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 210 LGGHSDLL----IGLASANEECWPLLRSTYDAMAmlpgAEDCQLALRGMRTLHLRLKEVERKALDLAAWLGNRDEVEKVL 285
Cdd:PRK08133 209 LDGQGRVLggavVGSKELMEEVFGFLRTAGPTLS----PFNAWVFLKGLETLSLRMEAHSANALALAEWLEAHPGVERVF 284
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 768801298 286 HPAFEDCPGHEYWVRDYKGSSGLFSIVLKNGftRAGLEKMVEGMKVL 332
Cdd:PRK08133 285 YPGLPSHPQHELAKRQQKGGGAIVSFEVKGG--REAAWRVIDATRLI 329
|
|
| MET17 |
COG2873 |
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid ... |
20-337 |
6.12e-47 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid transport and metabolism]; O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 442120 [Multi-domain] Cd Length: 428 Bit Score: 164.05 E-value: 6.12e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 20 GRNPDEQSGFVNPPLYKGSTIILK------KLSDLEqRKGRFYGTAGSPTIDNLENAWTHLTGGAGTVLSASGLGSISLA 93
Cdd:COG2873 16 GQEPDPTTGARAVPIYQTTSYVFDdaehaaDLFALK-EPGNIYTRIMNPTTDVLEKRIAALEGGVAALATASGQAAITLA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 94 LLALSKAGDHILMTDSVYVPTRMLCDGLLAKFGVETDYYDPSIGKDIEKLVKPNTTVIFLESPGSGTMEVQDIPALVSVA 173
Cdd:COG2873 95 ILNLAEAGDHIVASSSLYGGTYNLFAHTLPRLGIEVRFVDPDDPEAFEAAIDPNTKAIFGETIGNPALDVLDIEAIAEIA 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 174 KKHGIKTILDNTWATPLFFDAHAHGIDISVEAGTKYLGGHSDLLIGLA--------SANEEcWP---------------- 229
Cdd:COG2873 175 HEHGVPLIVDNTFATPYLCRPIEHGADIVVHSATKYIGGHGTSIGGVIvdggnfdwAANGK-FPeltepdpsyhglvyte 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 230 --------------LLRSTYDAMAmlpgAEDCQLALRGMRTLHLRlkeVER---KALDLAAWLGNRDEVEKVLHPAFEDC 292
Cdd:COG2873 254 afgnaafitkarvqLLRDLGAALS----PFNAFLLLQGLETLSLR---MERhveNALKVAEFLEAHPKVAWVNYPGLPSH 326
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 768801298 293 PGHEYWVRDY-KGSSGLFSIVLKNGFTRAglEKMVEGmkvLQLgFS 337
Cdd:COG2873 327 PYHELAQKYLpKGAGGVLTFGLKGGREAG--KKFIDS---LKL-FS 366
|
|
| PRK08249 |
PRK08249 |
cystathionine gamma-synthase family protein; |
48-317 |
2.04e-46 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236202 [Multi-domain] Cd Length: 398 Bit Score: 162.22 E-value: 2.04e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 48 LEQRKGRFYGTAGSPTIDNLENAWTHLTGGAGTVLSASGLGSISLALLALSKAGDHILMTDSVYVPTRMLCDGLLAKFGV 127
Cdd:PRK08249 50 LGKKPGHIYSRNTNPTVQAFEEKVRILEGAEAATAFSTGMAAISNTLYTFLKPGDRVVSIKDTYGGTNKIFTEFLPRMGV 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 128 ETDYYDPSIGKDIEKLVKPNTTVIFLESPGSGTMEVQDIPALVSVAKKHGIKTILDNTWATPLFFDAHAHGIDISVEAGT 207
Cdd:PRK08249 130 DVTLCETGDHEQIEAEIAKGCDLLYLETPTNPTLKIVDIERLAAAAKKVGALVVVDNTFATPINQNPLALGADLVIHSAT 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 208 KYLGGHSDLLIGLASANEECWPLLR-------STYDAMAmlpgaedCQLALRGMRTLHLRLKEVERKALDLAAWLGNRDE 280
Cdd:PRK08249 210 KFLSGHADALGGVVCGSKELMEQVYhyreingATMDPMS-------AYLILRGMKTLKLRVRQQQESAMALAKYLQTHPK 282
|
250 260 270
....*....|....*....|....*....|....*..
gi 768801298 281 VEKVLHPAFEDCPGHEYWVRDYKGSSGLFSIVLKNGF 317
Cdd:PRK08249 283 VEAVYYPGLETHPNHEIAKAQMRGFGGILSFVLKGGM 319
|
|
| PRK08574 |
PRK08574 |
cystathionine gamma-synthase family protein; |
16-340 |
1.44e-43 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236298 [Multi-domain] Cd Length: 385 Bit Score: 154.07 E-value: 1.44e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 16 LSVIGRNPDEQSGFVNPPLYKGS---TIILKKLSDleqrKGRF--YGTAGSPTIDNLENAWTHLTGGAGTVLSASGLGSI 90
Cdd:PRK08574 6 DAVRGYRGSDPYGSLQPPIYLTAlfrQEGEAYPSD----RGFDlkYSREENPTLRPLEEALAKLEGGVDALAFNSGMAAI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 91 SLALLALSKAGDHILMTDSVYVPTRMLCDgLLAKFGVETDYYDPSIGKDIEKLVKPNTTVIFLESPGSGTMEVQDIPALV 170
Cdd:PRK08574 82 STLFFSLLKAGDRVVLPMEAYGTTLRLLK-SLEKFGVKVVLAYPSTEDIIEAIKEGRTKLVFIETMTNPTLKVIDVPEVA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 171 SVAKKHGIKTILDNTWATPLFFDAHAHGIDISVEAGTKYLGGHSDLLIGLASANEEcwPLLRSTYDAMAMLPG---AEDC 247
Cdd:PRK08574 161 KAAKELGAILVVDNTFATPLLYRPLRHGADFVVHSLTKYIAGHNDVVGGVAVAWSG--EFLEELWEWRRRLGTimqPFEA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 248 QLALRGMRTLHLRLKEVERKALDLAAWLGNRDEVEKVLHPAFEDCPGHEYWVRDYKGS--SGLFSIVLKNGftRAGLEKM 325
Cdd:PRK08574 239 YLVLRGLKTLEVRFERQCRNAMAIAEFLSEHPKVAEVYYPGLPSDPYHGVAKRLFGKDlyGGVVSFRVKGG--RDAVLKF 316
|
330
....*....|....*
gi 768801298 326 VEGMKVLQLGFSWGG 340
Cdd:PRK08574 317 LRSLKLIKPSPSLGG 331
|
|
| PRK07503 |
PRK07503 |
methionine gamma-lyase; Provisional |
1-334 |
1.28e-42 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 181005 [Multi-domain] Cd Length: 403 Bit Score: 152.26 E-value: 1.28e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 1 MIDRTElsKFGITTQLSVIGRNPDEQSGFVNPPLYKGSTIILKklsDLE--------QRKGRFYGTAGSPTIDNLENAWT 72
Cdd:PRK07503 1 MRDSHN--NTGFSTRAIHHGYDPLDHGGALVPPVYLTATFAFP---TAEygaecfagEEEGHFYSRISNPTLALLEQRMA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 73 HLTGGAGTVLSASGLGSISLALLALSKAGDHILMTDSVYVPTRMLCDGLLAKFGVETDYYDPSIGKDIEKLVKPNTTVIF 152
Cdd:PRK07503 76 SLEGGEAAVALASGMGAITATLWTLLRPGDEVIVDQTLYGCTFAFLHHGLGEFGVTVRHVDLTDPAALKAAISDKTRMVY 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 153 LESPGSGTMEVQDIPALVSVAKKHGIKTILDNTWATPLFFDAHAHGIDISVEAGTKYLGGHSDLLIGLASANEECWPLLR 232
Cdd:PRK07503 156 FETPANPNMRLVDIAAVAEIAHGAGAKVVVDNTYCTPYLQRPLELGADLVVHSATKYLGGHGDITAGLVVGGKALADRIR 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 233 --STYDAMAMLPGAEDCQLALRGMRTLHLRLKEVERKALDLAAWLGNRDEVEKVLHPAFEDCPGHEYWVRDYKGSSGLFS 310
Cdd:PRK07503 236 leGLKDMTGAVMSPFDAFLLMRGLKTLALRMDRHCASAQAVAEWLARHPAVELVHYPGLPSFAQHALAQRQMALPGGMIA 315
|
330 340
....*....|....*....|....
gi 768801298 311 IVLKngftrAGLEKMVEGMKVLQL 334
Cdd:PRK07503 316 FELK-----GGIAAGRRFMNALQL 334
|
|
| PRK08045 |
PRK08045 |
cystathionine gamma-synthase; Provisional |
20-340 |
2.51e-42 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 169194 [Multi-domain] Cd Length: 386 Bit Score: 150.82 E-value: 2.51e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 20 GRNPDEQSGFVNPPLYKGSTIilkKLSDLEQRKGRFYGTAGSPTIDNLENAWTHLTGGAGTVLSASGLGSISLALLALSK 99
Cdd:PRK08045 13 GLNDDEQYGCVVPPIHLSSTY---NFTGFNEPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAIHLVTTVFLK 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 100 AGDHILMTDSVYVPTRMLCDGLLAKFGVETDYYDPSIGKDIEKLVKPNTTVIFLESPGSGTMEVQDIPALVSVAKKHGIK 179
Cdd:PRK08045 90 PGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALAEKPKLVLVESPSNPLLRVVDIAKICHLAREAGAV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 180 TILDNTWATPLFFDAHAHGIDISVEAGTKYLGGHSDLLIGLASA-NEECWPLLRSTYDAMAMLPGAEDCQLALRGMRTLH 258
Cdd:PRK08045 170 SVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAkDPDVVTELAWWANNIGVTGGAFDSYLLLRGLRTLV 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 259 LRLKEVERKALDLAAWLGNRDEVEKVLHPAFEDCPGHEYWVRDYKGSSGLFSIVLKNGftRAGLEKMVEGMKVLQLGFSW 338
Cdd:PRK08045 250 PRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDGD--EQTLRRFLGGLSLFTLAESL 327
|
..
gi 768801298 339 GG 340
Cdd:PRK08045 328 GG 329
|
|
| PRK07582 |
PRK07582 |
cystathionine gamma-lyase; Validated |
56-340 |
2.50e-39 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 236061 Cd Length: 366 Bit Score: 142.44 E-value: 2.50e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 56 YGTAGSPTIDNLENAWTHLTGGaGTVLSASGLGSISLALLALSKAGDHILMTDSVYVPTRMLCDGLLAKFGVETDYYdPS 135
Cdd:PRK07582 45 YGRASNPTWRALEAALGELEGA-EALVFPSGMAAITAVLRALLRPGDTVVVPADGYYQVRALAREYLAPLGVTVREA-PT 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 136 IGKDIEKLvkPNTTVIFLESPGSGTMEVQDIPALVSVAKKHGIKTILDNTWATPLFFDAHAHGIDISVEAGTKYLGGHSD 215
Cdd:PRK07582 123 AGMAEAAL--AGADLVLAETPSNPGLDVCDLAALAAAAHAAGALLVVDNTTATPLGQRPLELGADLVVASDTKALTGHSD 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 216 LLIG-LASANEECWPLLRSTYDAMAMLPGAEDCQLALRGMRTLHLRLKEVERKALDLAAWLGNRDEVEKVLHPAFEDCPG 294
Cdd:PRK07582 201 LLLGyVAGRDPELMAAVERWRLLAGAIPGPFEAWLAHRSLGTLGLRFARQCANALAVAELLAGHPAVRGVRYPGLPGDPA 280
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 768801298 295 HEYWVRDYKGSSGLFSIVLKngfTRAGLEKMVEGMKVLQLGFSWGG 340
Cdd:PRK07582 281 HEVAARQMRRFGGLVSFELA---DAAAAERFVAASRLVVAATSFGG 323
|
|
| cysta_beta_ly_E |
TIGR01329 |
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase ... |
12-339 |
1.74e-38 |
|
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys.
Pssm-ID: 273557 [Multi-domain] Cd Length: 378 Bit Score: 140.73 E-value: 1.74e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 12 ITTQLsVIGRNPDEQSGFVNPPLYKGSTIilkKLSDLEQRKGRFYGTAGSPTIDNLENAWTHLTGGAGTVLSASGLGSIS 91
Cdd:TIGR01329 1 LSTLL-VNTDNKNDPYDASSMPIYQTATF---KQPLAIENGPYDYTRSGNPTRTALESLLAKLDKADRAFAFSSGMAALD 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 92 lALLALSKAGDHILMTDSVYVPTRMLCDGLLAKFGVETDYYDPSIGKDIEKLVKPNTTVIFLESPGSGTMEVQDIPALVS 171
Cdd:TIGR01329 77 -VITRLLNNGDEIIAGDDLYGGTDRLLTQVVPRSGVVVVHVDTTDLDKVKAALGPKTKLVLLESPTNPLQKIVDIRKISE 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 172 VAKKHGIKTILDNTWATPLFFDAHAHGIDISVEAGTKYLGGHSDLLIGLASANEE-----CWPLLRSTYDAMAMLpgaeD 246
Cdd:TIGR01329 156 MAHAQNALVVVDNTMMSPLLCNPLELGADIVYHSATKFLAGHSDVMAGVLAVKGEeiakkVYFLQNSTGSGLAPF----D 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 247 CQLALRGMRTLHLRLKEVERKALDLAAWLGNRDEVEKVLHPAFEDCPGHEYWVRDYKGSSGLFSIVlKNGFTRAglEKMV 326
Cdd:TIGR01329 232 CWLLLRGIKTLAIRIEKQQENARAIAMFLSTHPRVKKVRYAGLPSHPGFHLHFSQAKGAGSVLSFE-TGSVALS--KRLV 308
|
330
....*....|...
gi 768801298 327 EGMKVLQLGFSWG 339
Cdd:TIGR01329 309 EATKLFSITVSFG 321
|
|
| PRK05939 |
PRK05939 |
cystathionine gamma-synthase family protein; |
26-337 |
3.42e-37 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 235650 [Multi-domain] Cd Length: 397 Bit Score: 137.51 E-value: 3.42e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 26 QSGFVNPPLYKGSTIILKKLSDL----EQRKGRF-YGTAGSPTIDNLENAWTHLTGGAGTVLSASGLGSISLALLALSKA 100
Cdd:PRK05939 6 EHGAVHKPIHTSVTYGYEDARDLidvfQGKKPGFtYARQGTPTTAALEAKITKMEGGVGTVCFATGMAAIAAVFLTLLRA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 101 GDHILMTDSVYVPTRMLCdGLLAKFGVETDYYDPSIGKDIEKLVKPNTTVIFLESPGSGTMEVQDIPALVSVAKKHGIKT 180
Cdd:PRK05939 86 GDHLVSSQFLFGNTNSLF-GTLRGLGVEVTMVDATDVQNVAAAIRPNTRMVFVETIANPGTQVADLAGIGALCRERGLLY 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 181 ILDNTWATPLFFDAHAHGIDISVEAGTKYLGGHSDLLIGLA-------------------SANEECWPLL----RSTYDA 237
Cdd:PRK05939 165 VVDNTMTSPWLFRPKDVGASLVINSLSKYIAGHGNALGGAVtdtglfdwsaypnifpayrKGDPQQWGLTqirkKGLRDM 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 238 MAMLpGAEDCQLALRGMRTLHLRLKEVERKALDLAAWLGNRDEVEKVLHPAFEDCPGHEYWVRDYKGSSGLFSIVLKNGf 317
Cdd:PRK05939 245 GATL-SSEAAHRIAIGAETLALRVDRSCSNALALAQFLEAHPKVARVYYPGLASHPQHARATELFRHYGGLLSFELADG- 322
|
330 340
....*....|....*....|
gi 768801298 318 traglEKMVEGMKVLQLGFS 337
Cdd:PRK05939 323 -----IDCFDFLNRLKLVIK 337
|
|
| PRK06460 |
PRK06460 |
hypothetical protein; Provisional |
24-325 |
4.81e-37 |
|
hypothetical protein; Provisional
Pssm-ID: 235807 [Multi-domain] Cd Length: 376 Bit Score: 136.50 E-value: 4.81e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 24 DEQSGFVNPPLYKGSTIILKklsdlEQRKGRfYGTAGSPTIDNLENAWTHLTGGAGTVLSASGLGSISLALLALSKAGDH 103
Cdd:PRK06460 13 DEATGAITTPIYQTTAYHYP-----EGEKYR-YSREANPTVLELTKKIVELENAEMGVAFSSGMGAISTTALALLKPGNS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 104 ILMTDSVYVPTRMLCDGLLAKFGVETDYYDPSIGKDIEKLVKPNTTVIFLESPGSGTMEVQDIPALVSVAKKHGIKTILD 183
Cdd:PRK06460 87 VLVHRDMFGRSYRFFTDYLKNWGVNVDASNPGSDNIIEKAKSKRYDVVFVENITNPLLRVVDITELSKVCKENGSILIVD 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 184 NTWATPLFFDAHAHGIDISVEAGTKYLGGHSDLLIGLASANEECWPLLRSTYDAMAMLPGAEDCQLALRGMRTLHLRLKE 263
Cdd:PRK06460 167 ATFSTPINQKPLELGADIVVHSASKFLAGHNDVIAGLAAGYGKLLNVIDQMRRTLGTSLDPHAAYLTLRGIKTLKIRMDV 246
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 768801298 264 VERKALDLAAWLGNRDEVEKVLHPAFEDCPGHEYWVRDYKGSSGLFSIVLKNGFTRAgLEKM 325
Cdd:PRK06460 247 INRNAEQIAEFLEGHPKVVKVYYPGLKSHVDYEIARRVLKGFGGVLSFEVNGGQESA-LKVM 307
|
|
| PRK07812 |
PRK07812 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
13-296 |
1.21e-36 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236105 Cd Length: 436 Bit Score: 136.81 E-value: 1.21e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 13 TTQLSViGRNPDEQSGFVNPPLYKGSTIILKK------LSDLEQrKGRFYGTAGSPTIDNLENAWTHLTGGAGTVLSASG 86
Cdd:PRK07812 16 TKQIHA-GQTPDPATNARALPIYQTTSYTFDDtdhaaaLFGLAE-PGNIYTRIMNPTQDVVEQRIAALEGGVAALLLASG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 87 LGSISLALLALSKAGDHILMTDSVYVPTRMLCDGLLAKFGVETDYY-DPSIGKDIEKLVKPNTTVIFLESPGSGTMEVQD 165
Cdd:PRK07812 94 QAAETFAILNLAGAGDHIVSSPRLYGGTYNLFHYTLPKLGIEVSFVeDPDDLDAWRAAVRPNTKAFFAETISNPQIDVLD 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 166 IPALVSVAKKHGIKTILDNTWATPLFFDAHAHGIDISVEAGTKYLGGHSDLLIGL------------------------- 220
Cdd:PRK07812 174 IPGVAEVAHEAGVPLIVDNTIATPYLIRPLEHGADIVVHSATKYLGGHGTAIAGVivdggtfdwtqgrfpgfttpdpsyh 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 221 ----------ASANEECWPLLRSTYDAMAMLpgaeDCQLALRGMRTLHLRLKEVERKALDLAAWLGNRDEVEKVLHPAFE 290
Cdd:PRK07812 254 gvvfaelgppAYALKARVQLLRDLGSAISPF----NAFLIAQGLETLSLRIERHVANAQRVAEFLEARDEVASVNYAGLP 329
|
....*.
gi 768801298 291 DCPGHE 296
Cdd:PRK07812 330 SSPWYE 335
|
|
| PRK08776 |
PRK08776 |
O-succinylhomoserine (thiol)-lyase; |
20-340 |
1.84e-36 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181554 [Multi-domain] Cd Length: 405 Bit Score: 135.89 E-value: 1.84e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 20 GRNPDEQSGFVNPPLYKGSTIILKKLSDLEQRKgrfYGTAGSPTIDNLENAWTHLTGGAGTVLSASGLGSISLALLALSK 99
Cdd:PRK08776 21 GIDRDTAYGAVTPPIVLSSNFSFDGFGNKRQYD---YTRSGNPTRDLLGEALAELEGGAGGVITATGMGAINLVLNALLQ 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 100 AGDHILMTDSVYVPTRMLCDGLlAKFG----VETDYYDPsigKDIEKLVKPNTTVIFLESPGSGTMEVQDIPALVSVAKK 175
Cdd:PRK08776 98 PGDTLVVPHDAYGGSWRLFNAL-AKKGhfalITADLTDP---RSLADALAQSPKLVLIETPSNPLLRITDLRFVIEAAHK 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 176 HGIKTILDNTWATPLFFDAHAHGIDISVEAGTKYLGGHSDLLIGLASANE-ECWPLLRSTYDAMAMLPGAEDCQLALRGM 254
Cdd:PRK08776 174 VGALTVVDNTFLSPALQKPLEFGADLVLHSTTKYINGHSDVVGGAVVARDaELHQQLVWWANALGLTGSPFDAFLTLRGL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 255 RTLHLRLKEVERKALDLAAWLGNRDEVEKVLHPAFEDCPGHEYWVRDYKGSSGLFSIVLKNGftRAGLEKMVEGMKVLQL 334
Cdd:PRK08776 254 RTLDARLRVHQENADAIAALLDGHAAVNQVYYPGLASHPGHALAARQQKGFGAMLSFELEGG--EAAVRAFVDGLRYFTL 331
|
....*.
gi 768801298 335 GFSWGG 340
Cdd:PRK08776 332 AESLGG 337
|
|
| PRK08134 |
PRK08134 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
20-331 |
8.15e-36 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236159 Cd Length: 433 Bit Score: 134.48 E-value: 8.15e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 20 GRNPDEQSGFVNPPLYKGSTIILKK------LSDLEqRKGRFYGTAGSPTIDNLENAWTHLTGGAGTVLSASGLGSISLA 93
Cdd:PRK08134 17 GAAPDPATGARAVPIHLTTSFVFRDsdhaaaLFNLE-RAGHVYSRISNPTVAVLEERVAALEGGVGAIATASGQAALHLA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 94 LLALSKAGDHILMTDSVYVPTRMLCDGLLAKFGVETDYYDPSIGKDIEKLVKPNTTVIFLESPGSGTMEVQDIPALVSVA 173
Cdd:PRK08134 96 IATLMGAGSHIVASSALYGGSHNLLHYTLRRFGIETTFVKPGDIDGWRAAIRPNTRLLFGETLGNPGLEVLDIPTVAAIA 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 174 KKHGIKTILDNTWATPLFFDAHAHGIDISVEAGTKYLGGHSDLLIGL----------ASANeecWPLLRSTYDAM----- 238
Cdd:PRK08134 176 HEAGVPLLVDSTFTTPYLLRPFEHGADLVYHSATKFLGGHGTAIGGVlvdggrfdweASGK---FPELTEPYAGFhgmvf 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 239 ------------AMLPGAED---CQ------LALRGMRTLHLRLKEVERKALDLAAWLGNRDEVEKVLHPAFEDCPGHEY 297
Cdd:PRK08134 253 aeestvaafllrARREGLRDfgaCLspmnawQLLQGIETLPLRMERHVANTRKVVAFLASHPAVARVAHPELESHPDHAL 332
|
330 340 350
....*....|....*....|....*....|....*
gi 768801298 298 WVRDY-KGSSGLFSIVLKNGftRAGLEKMVEGMKV 331
Cdd:PRK08134 333 AKRLLpRGAGSVFSFDLKGG--RAAGRKFIESLKL 365
|
|
| PRK07504 |
PRK07504 |
O-succinylhomoserine sulfhydrylase; Reviewed |
49-316 |
1.84e-35 |
|
O-succinylhomoserine sulfhydrylase; Reviewed
Pssm-ID: 168979 [Multi-domain] Cd Length: 398 Bit Score: 132.96 E-value: 1.84e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 49 EQRKGRF--------YGTAGSPTIDNLENAWTHLTGGAGTVLSASGLGSISLALLALSKAGDHILMTDSVYVPTRMLCDG 120
Cdd:PRK07504 44 EAAEARFkgedpgfiYSRYSNPTVDMFEKRMCALEGAEDARATASGMAAVTAAILCQVKAGDHVVAARALFGSCRYVVET 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 121 LLAKFGVETDYYDpsiGKDI---EKLVKPNTTVIFLESPGSGTMEVQDIPALVSVAKKHGIKTILDNTWATPLFFDAHAH 197
Cdd:PRK07504 124 LLPRYGIESTLVD---GLDLdnwEKAVRPNTKVFFLESPTNPTLEVIDIAAVAKIANQAGAKLVVDNVFATPLFQKPLEL 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 198 GIDISVEAGTKYLGGHSDLLIGLASANEEcW------PLLRSTYDAMAMLpgaeDCQLALRGMRTLHLRLKEVERKALDL 271
Cdd:PRK07504 201 GAHIVVYSATKHIDGQGRCLGGVVLSDKA-WieehlqDYFRHTGPSLSPF----NAWTLLKGLETLPVRVRQQTESAAAI 275
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 768801298 272 AAWLGNRDEVEKVLHPAFEDCPGHEYWVRDYKGSSGLFSIVLKNG 316
Cdd:PRK07504 276 ADFLAGHPKVARVIYPGRADHPQADIIAKQMTGGSTLVAFELKGG 320
|
|
| PRK08248 |
PRK08248 |
homocysteine synthase; |
5-331 |
6.52e-32 |
|
homocysteine synthase;
Pssm-ID: 236201 [Multi-domain] Cd Length: 431 Bit Score: 123.80 E-value: 6.52e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 5 TELSKFGITTQLSVIGRNPDEQSGFVNPPLYKGSTIILK------KLSDLeQRKGRFYGTAGSPTIDNLENAWTHLTGGA 78
Cdd:PRK08248 2 SEERTFRLETLAIHAGQEIDPTTGSRAVPIYQTTSYGFRdsehaaNLFSL-KEFGNIYTRIMNPTTDVFEKRIAALEGGI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 79 GTVLSASGLGSISLALLALSKAGDHILMTDSVYVPTRMLCDGLLAKFGVETDYYDPSIGKDIEKLVKPNTTVIFLESPGS 158
Cdd:PRK08248 81 GALAVSSGQAAITYSILNIASAGDEIVSSSSLYGGTYNLFAHTLPKLGITVKFVDPSDPENFEAAITDKTKALFAETIGN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 159 GTMEVQDIPALVSVAKKHGIKTILDNTWATPLFFDAHAHGIDISVEAGTKYLGGH------------------SDLLIGL 220
Cdd:PRK08248 161 PKGDVLDIEAVAAIAHEHGIPLIVDNTFASPYLLRPIEHGADIVVHSATKFIGGHgtsiggvivdsgkfdwkgSGKFPGL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 221 ASAN---------EECWP----------LLRSTYDAMAMLpgaeDCQLALRGMRTLHLRLKEVERKALDLAAWLGNRDEV 281
Cdd:PRK08248 241 TEPDpsyhglvytDAVGEaayitkarvqLLRDLGAALSPF----NSFLLLQGLETLHLRMERHSENALAVAKFLEEHEAV 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 768801298 282 EKVLHPAFEDCPGHEYwVRDY--KGSSGLFSIVLKNGfTRAGlEKMVEGMKV 331
Cdd:PRK08248 317 EWVSYPGLPSHPSYEL-AKKYlpKGQGAILTFGIKGG-VEAG-KKLIDSVKL 365
|
|
| PRK07049 |
PRK07049 |
cystathionine gamma-synthase family protein; |
14-340 |
9.91e-32 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 180809 [Multi-domain] Cd Length: 427 Bit Score: 123.24 E-value: 9.91e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 14 TQLSVIGRNPDEQSGFVNPPLYKGSTIILKKLSD-------LEQRK--------GRFYGTAGSPTIDNLENAWTHLTGGA 78
Cdd:PRK07049 20 TQMLNYGYDPELSEGAVKPPVFLTSTFVFRSAEDgrdffdyVSGRKeppagegaGLVYSRFNHPNSEIVEDRLAVYEGAE 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 79 GTVLSASGLGSISLALLALSKAGDHILMTDSVYVPTRMLCDGLLAKFGVET----DYYDP-SIGKDIEK-LVKPNTTVIF 152
Cdd:PRK07049 100 SAALFSSGMSAIATTLLAFVRPGDVILHSQPLYGGTETLLAKTFRNFGVGAvgfaDGLSEaAIGAAAEAaAAKGRVSLIL 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 153 LESPGSGTMEVQDIPALVSVA----KKHGIKTIL--DNTWATPLFFDAHAHGIDISVEAGTKYLGGHSDLLIGLASANEE 226
Cdd:PRK07049 180 IETPANPTNSLVDVAAVRRVAdaieARQGHRPIIacDNTLLGPVFQKPLEHGADLSVYSLTKYVGGHSDLVAGAVLGRKA 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 227 CWPLLRSTYDAMAMLPGAEDCQLALRGMRTLHLRLKEVERKALDLAAWLGNRDEVEKVLHPAF--EDCPGHEYWVRDYKG 304
Cdd:PRK07049 260 LIRQVRALRSAIGTQLDPHSCWMLGRSLETLVLRMERANRNARAVAEFLRDHPKVEKLHYLPFldPDSAYGAVYKRQCTG 339
|
330 340 350
....*....|....*....|....*....|....*.
gi 768801298 305 SSGLFSIVLKNGftRAGLEKMVEGMKVLQLGFSWGG 340
Cdd:PRK07049 340 AGSTFSFDIKGG--QAAAFRFLNALQIFKLAVSLGG 373
|
|
| PLN02509 |
PLN02509 |
cystathionine beta-lyase |
30-339 |
1.51e-31 |
|
cystathionine beta-lyase
Pssm-ID: 178125 [Multi-domain] Cd Length: 464 Bit Score: 123.21 E-value: 1.51e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 30 VNPPLYKGSTiiLKKLSDLEQrkGRF-YGTAGSPTIDNLENAWTHLTGGAGTVLSASGLGSISlALLALSKAGDHILMTD 108
Cdd:PLN02509 104 MSTPLYQTAT--FKQPSAIEN--GPYdYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALS-AVTHLIKNGEEIVAGD 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 109 SVYVPTRMLCDGLLAKFGVETDYYDPSIGKDIEKLVKPNTTVIFLESPGSGTMEVQDIPALVSVAKKHGIKTILDNTWAT 188
Cdd:PLN02509 179 DVYGGSDRLLSQVVPRSGVVVKRVNTTNLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKIAEMAHAQGALVLVDNSIMS 258
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 189 PLFFDAHAHGIDISVEAGTKYLGGHSDLLIGLASANEEcwPLLRSTYdamaMLPGAE-------DCQLALRGMRTLHLRL 261
Cdd:PLN02509 259 PVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGE--KLAKEVY----FLQNSEgsglapfDCWLCLRGIKTMALRI 332
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 262 KEVERKALDLAAWLGNRDEVEKVLHPAFEDCPGHEYWVRDYKGSSGLFSivlkngFTRAGLE---KMVEGMKVLQLGFSW 338
Cdd:PLN02509 333 EKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFS------FITGSVAlskHLVETTKYFSIAVSF 406
|
.
gi 768801298 339 G 339
Cdd:PLN02509 407 G 407
|
|
| PRK06434 |
PRK06434 |
cystathionine gamma-lyase; Validated |
11-290 |
2.02e-31 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 102374 [Multi-domain] Cd Length: 384 Bit Score: 121.55 E-value: 2.02e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 11 GITTQLSVIGRNPDEQSGFVNPPLYKGSTIIL-----KKLSDLEQRKGRFYGTAGSPTIDNLENAWTHLTGGAGTVLSAS 85
Cdd:PRK06434 8 GFNTRAVQSGELRDPRFGNVTTPIFETSTFVYpnsekEAYMDSTRGMPYIYTRWGNPTVQAFEEKYAVLENAEHALSFSS 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 86 GLGSISLALLALSKAGDHILMTDSVYVPTRMLCDGLLAKFGVETDYYdpsigkDIEKL----VKP-NTTVIFLESPGSGT 160
Cdd:PRK06434 88 GMGAITSAILSLIKKGKRILSISDLYGQTFYFFNKVLKTLGIHVDYI------DTDRLnsldFDPsNYDLIYAESITNPT 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 161 MEVQDIPALVSVAkkHGIKTILDNTWATPLFFDAHAHGIDISVEAGTKYLGGHSDLLIGLASANEECW----PLLRSTYD 236
Cdd:PRK06434 162 LKVPDIKNVSSFC--HENDVIVDATFASPYNQNPLDLGADVVIHSATKYISGHSDVVMGVAGTNNKSIfnnlVERRKTLG 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 768801298 237 AMamlPGAEDCQLALRGMRTLHLRLKEVERKALDLAAWLGNRDEVEKVLHPAFE 290
Cdd:PRK06434 240 SN---PDPIQAYLALRGLKTLGLRMEKHNKNGMELARFLRDSKKISNVYYPDTE 290
|
|
| PRK06084 |
PRK06084 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
20-316 |
5.31e-31 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 180392 [Multi-domain] Cd Length: 425 Bit Score: 121.16 E-value: 5.31e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 20 GRNPDEQSGFVNPPLYKGSTIILKKL---SDLEQRK--GRFYGTAGSPTIDNLENAWTHLTGGAGTVLSASGLGSISLAL 94
Cdd:PRK06084 11 GYSPDPTTKAVAVPIYQTTSYAFDDTqhgADLFDLKvpGNIYTRIMNPTNDVLEQRVAALEGGVGALAVASGMAAITYAI 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 95 LALSKAGDHILMTDSVYVPTRMLCDGLLAKFGVETDYYDPSIGKDIEKLVKPNTTVIFLESPGSGTMEVQDIPALVSVAK 174
Cdd:PRK06084 91 QTIAEAGDNIVSVAKLYGGTYNLLAHTLPRIGIETRFAAHDDIAALEALIDERTKAVFCESIGNPAGNIIDIQALADAAH 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 175 KHGIKTILDNTWATPLFFDAHAHGIDISVEAGTKYLGGHSDLLIGLA--------SANEECWPLLRS--------TY-DA 237
Cdd:PRK06084 171 RHGVPLIVDNTVATPVLCRPFEHGADIVVHSLTKYIGGHGTSIGGIVvdsgkfpwAEHKERFALLNTpdpsyhgvTYtEA 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 238 MAMLPGAEDCQ-----------------LALRGMRTLHLRLKEVERKALDLAAWLGNRDEVEKVLHPAFEDCPGHEYWVR 300
Cdd:PRK06084 251 FGPAAFIGRCRvvplrnmgaalspfnafLILQGLETLALRMERHTENALKVARYLQQHPQVAWVKYAGLPDHPEHELARR 330
|
330
....*....|....*..
gi 768801298 301 DYKGS-SGLFSIVLKNG 316
Cdd:PRK06084 331 YMGGKpASILSFGIKGG 347
|
|
| PRK08861 |
PRK08861 |
O-succinylhomoserine (thiol)-lyase; |
20-340 |
1.05e-30 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181567 [Multi-domain] Cd Length: 388 Bit Score: 119.61 E-value: 1.05e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 20 GRNPDEQSGFVNPPLYKGSTIILKKLSDLEQRKgrfYGTAGSPTIDNLENAWTHLTGGAGTVLSASGLGSISLALLALSK 99
Cdd:PRK08861 14 GIESDSQYHAVVPPIYLSTNYGFPAFGEVPKYD---YTRSGNPNRGLLEQTLSELESGKGAVVTNCGTSALNLWVSALLG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 100 AGDHILMTDSVYVPTRMLCDGLLAKFGVETDYYDPSIGKDIEKLVKPNTTVIFLESPGSGTMEVQDIPALVSVAKKHGIK 179
Cdd:PRK08861 91 PDDLIVAPHDCYGGTYRLFNTRANKGDFKVQFVDQSDAAALDAALAKKPKLILLETPSNPLVRVVDIAELCQKAKAVGAL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 180 TILDNTWATPLFFDAHAHGIDISVEAGTKYLGGHSDLLIG-LASANEECWPLLRSTYDAMAMLPGAEDCQLALRGMRTLH 258
Cdd:PRK08861 171 VAVDNTFLTPVLQKPLELGADFVIHSTTKYINGHSDVIGGvLITKTKEHAEELAWWGNCIGATGTPFDSYMTLRGIRTLG 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 259 LRLKEVERKALDLAAWLGNRDEVEKVLHPAFEDCPGHEYWVRDYKGSSGLFSIVLKNGFTRagLEKMVEGMKVLQLGFSW 338
Cdd:PRK08861 251 ARMRVHEESAQQILAYLQTQSLVGTIYHPSLPEHPGHEIAKKQQSGFGSMLSFEFAGSFEQ--LKVFVKALALFSLAESL 328
|
..
gi 768801298 339 GG 340
Cdd:PRK08861 329 GG 330
|
|
| PRK06702 |
PRK06702 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
33-320 |
2.46e-30 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 102505 [Multi-domain] Cd Length: 432 Bit Score: 119.39 E-value: 2.46e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 33 PLYKGSTIILKKLSDLE-----QRKGRFYGTAGSPTIDNLENAWTHLTGGAGTVLSASGLGSISLALLALSKAGDHILMT 107
Cdd:PRK06702 27 PLYQSTTYKYDTSDDLAalfnlEAEGYIYTRIGNPTLAAFEQKLAELEGGVGAVATASGQAAIMLAVLNICSSGDHLLCS 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 108 DSVYVPTRMLCDGLLAKFGVETDYYDPSIGKD-IEKLVKPNTTVIFLESPGSGTMEVQDIPALVSVAKKHGIKTILDNTW 186
Cdd:PRK06702 107 STVYGGTFNLFGVSLRKLGIDVTFFNPNLTADeIVALANDKTKLVYAESLGNPAMNVLNFKEFSDAAKELEVPFIVDNTL 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 187 ATPLFFDAHAHGIDISVEAGTKYLGGHSDLLIGLA------SANEECWPLL---RSTYDAMA-----------------M 240
Cdd:PRK06702 187 ATPYLCQAFEHGANIIVHSTTKYIDGHASSLGGIVidggnfDWTNGKYPELvepDPSYHGVSyvqnfgaaayivkarvqL 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 241 LPGAEDCQLALR------GMRTLHLRLKEVERKALDLAAWLGNRDEVEKVLHPAF---EDCPGHEYWVRdyKGSSGLFSI 311
Cdd:PRK06702 267 LRDYGNCMSPFNayisniGLETLHLRMERHSENALAVAKWLADHERIEWVNYPGLdsnENYSLAQKYLK--KGASGVLTF 344
|
....*....
gi 768801298 312 VLKNGFTRA 320
Cdd:PRK06702 345 GIKGGLEAA 353
|
|
| PRK05994 |
PRK05994 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
1-332 |
3.58e-29 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 180344 [Multi-domain] Cd Length: 427 Bit Score: 116.35 E-value: 3.58e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 1 MIDRTElskfGITTQLSVIGRNPDEQSGFVNPPLYKGSTIILK------KLSDLeQRKGRFYGTAGSPTIDNLENAWTHL 74
Cdd:PRK05994 1 MTDRSP----GFATLAVHAGAQPDPTTGARATPIYQTTSFVFNdadhaaSLFGL-QAFGNIYTRITNPTNAVLEERVAAL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 75 TGGAGTVLSASGLGSISLALLALSKAGDHILMTDSVYVPTRMLCDGLLAKFGVETDYYDPSIGKDIEKLVKPNTTVIFLE 154
Cdd:PRK05994 76 EGGTAALAVASGHAAQFLVFHTLLQPGDEFIAARKLYGGSINQFGHAFKSFGWQVRWADADDPASFERAITPRTKAIFIE 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 155 S---PGsGTmeVQDIPALVSVAKKHGIKTILDNTWATPLFFDAHAHGIDISVEAGTKYLGGHSDLLIGL----------A 221
Cdd:PRK05994 156 SianPG-GT--VTDIAAIAEVAHRAGLPLIVDNTLASPYLIRPIEHGADIVVHSLTKFLGGHGNSMGGIivdggtfdwsK 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 222 SANeecWPLL---RSTYDAMAM------LPGAEDCQ-LALR----------------GMRTLHLRLKEVERKALDLAAWL 275
Cdd:PRK05994 233 SGK---YPMLsepRPEYHGLVLhetfgnFAFAIAARvLGLRdlgpaispfnafliltGIETLPLRMQRHSDNALAVAEWL 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 768801298 276 GNRDEVEKVLHPAFEDCPGHEYwVRDY--KGSSGLFSIVLKNGFtRAGLeKMVEGMKVL 332
Cdd:PRK05994 310 KGHPKVSWVNYAGLPDDPYHAL-AQKYspKGAGAVFTFGLKGGY-EAGV-KLVSSLKLF 365
|
|
| PRK05613 |
PRK05613 |
O-acetylhomoserine/O-acetylserine sulfhydrylase; |
3-293 |
7.68e-29 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase;
Pssm-ID: 168128 [Multi-domain] Cd Length: 437 Bit Score: 115.35 E-value: 7.68e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 3 DRTELSKFGITTQLSVIGRNPDEQSGFVNPPLYKGSTIILkklSDLEQRKGRF--------YGTAGSPTIDNLENAWTHL 74
Cdd:PRK05613 5 DNSNADQWGFETRSIHAGQSVDSDTSARNLPIYQTTSYVF---DSAEHAKQRFaledlgpiYSRLTNPTVEALENRIASL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 75 TGGAGTVLSASGLGSISLALLALSKAGDHILMTDSVYVPTRMLCDGLLAKFGVETDYY-DPSIGKDIEKLVKPNTTVIFL 153
Cdd:PRK05613 82 EGGVHAVAFASGQAAETAAILNLAGAGDHIVTSPRLYGGTETLFLVTLNRLGIEVTFVeNPDDPESWQAAVQPNTKAFFG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 154 ESPGSGTMEVQDIPALVSVAKKHGIKTILDNTWATPLFFDAHAHGIDISVEAGTKYLGGHSDLLIGL-----------AS 222
Cdd:PRK05613 162 ETFANPQADVLDIPAVAEVAHRNQVPLIVDNTIATAALVRPLELGADVVVASLTKFYTGNGSGLGGVlidggkfdwtvER 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 223 ANEECWP-----------------------------LLRSTYDAmamlPGAEDCQLALRGMRTLHLRLKEVERKALDLAA 273
Cdd:PRK05613 242 DGKPVFPyfvtpdpayhglkyadlgapafglkaragLLRDTGAT----LSPFNAWVTAQGLDTLSLRLERHNENAIKVAE 317
|
330 340
....*....|....*....|
gi 768801298 274 WLGNRDEVEKVLHPAFEDCP 293
Cdd:PRK05613 318 FLNNHEKVAKVNFAGLKDSP 337
|
|
| PRK07810 |
PRK07810 |
O-succinylhomoserine sulfhydrylase; Provisional |
54-304 |
2.69e-28 |
|
O-succinylhomoserine sulfhydrylase; Provisional
Pssm-ID: 236103 [Multi-domain] Cd Length: 403 Bit Score: 113.29 E-value: 2.69e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 54 RF-YGTAGSPTIDNLENAWTHLTGGAGTVLSASGLGSISLALLALSKAGDHILMTDSVYVPTRMLCDGLLAKFGVETDYY 132
Cdd:PRK07810 61 RFvYSRYGNPTVSMFEERLRLIEGAEACFATASGMSAVFTALGALLGAGDRLVAARSLFGSCFVVCNEILPRWGVETVFV 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 133 DpsiGKDIEK----LVKPnTTVIFLESPGSGTMEVQDIPALVSVAKKHGIKTILDNTWATPLFFDAHAHGIDISVEAGTK 208
Cdd:PRK07810 141 D---GEDLSQweeaLSVP-TQAVFFETPSNPMQSLVDIAAVSELAHAAGAKVVLDNVFATPLLQRGLPLGADVVVYSGTK 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 209 YLGGHSDLLIGLASANEE-----CWPLLRSTYDAMAmlpgAEDCQLALRGMRTLHLRLKEVERKALDLAAWLGNRDEVEK 283
Cdd:PRK07810 217 HIDGQGRVLGGAILGDREyidgpVQKLMRHTGPALS----AFNAWVLLKGLETLALRVRHSNASALRIAEFLEGHPAVRW 292
|
250 260
....*....|....*....|.
gi 768801298 284 VLHPAFEDCPGHEYWVRDYKG 304
Cdd:PRK07810 293 VRYPFLPSHPQYDLAKRQMSG 313
|
|
| PLN02242 |
PLN02242 |
methionine gamma-lyase |
56-314 |
4.92e-23 |
|
methionine gamma-lyase
Pssm-ID: 215134 Cd Length: 418 Bit Score: 98.68 E-value: 4.92e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 56 YGTAGSPTIDNLENAWTHLTGGAGTVLSASGLGSISLALLALSKAGDHILMTDSVYVPTRMLCDGLLA-KFGVETDYYDP 134
Cdd:PLN02242 70 YSRHFNPTVLNLGRQMAALEGTEAAYCTASGMSAISSVLLQLCSSGGHVVASNTLYGGTHALLAHFLPrKCNITTTFVDI 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 135 SIGKDIEKLVKPNTT-VIFLESPGSGTMEVQDIPALVSVAKKHGIKTILDNTWAtPLFFDAHAHGIDISVEAGTKYLGGH 213
Cdd:PLN02242 150 TDLEAVKKAVVPGKTkVLYFESISNPTLTVADIPELARIAHEKGVTVVVDNTFA-PMVLSPARLGADVVVHSISKFISGG 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 214 SDLLIGLAsaneeCWP--LLRSTYDAMA---MLPGA-----EDCQLALRgMRTLHLRLKEVERKALDLAAWLgnRDEVEK 283
Cdd:PLN02242 229 ADIIAGAV-----CGPaeLVNSMMDLHHgalMLLGPtmnpkVAFELSER-LPHLSLRMKEHCRRAMEYAKRM--KELGLK 300
|
250 260 270
....*....|....*....|....*....|....*
gi 768801298 284 VLHPAFEDCPGHEYWV----RDYkGSSGLFSIVLK 314
Cdd:PLN02242 301 VIYPGLEDHPQHALLKsmanKGY-GFGGLLCLDMD 334
|
|
| PRK07269 |
PRK07269 |
cystathionine gamma-synthase; Reviewed |
12-287 |
2.04e-19 |
|
cystathionine gamma-synthase; Reviewed
Pssm-ID: 235983 Cd Length: 364 Bit Score: 87.95 E-value: 2.04e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 12 ITTQLSVIGRNPDEQSGFVNPPLYKGSTIilkKLSDLEQRKGRFYGTAGSPTIDNLENAWTHLTGGAGTVLSASGLGSIS 91
Cdd:PRK07269 7 INTILAQAGIKSDEATGALVTPLHFSTTY---QHPEFGQSTGFDYTRTKNPTRAKLEETLAAIESADYALATSSGMSAIV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 92 LALlalskagdHILMTDSVYVPTRMLCDGLLAKFG-VETD----YYDPSIGKDIEKLVKPNTTVIFLESPGSGTMEVQDI 166
Cdd:PRK07269 84 LAF--------SVFPVGSKVVAVRDLYGGSFRWFNqQEKEgrfhFTYANTEEELIAAIEEDTDIVYIETPTNPLMVEFDI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 167 PALVSVAKKHGIKTILDNTWATPLFFDAHAHGIDISVEAGTKYLGGHSDLLIG-LASANEECWPLLRSTYDAMAMLPGAE 245
Cdd:PRK07269 156 EKVAKLAHAKGAKVIVDNTFYSPIYQRPIELGADIVLHSATKYLSGHNDVLAGvVVTNDLELYEKLFYNLNTTGAVLSPF 235
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 768801298 246 DCQLALRGMRTLHLRLKEVERKALDLAAWLGNRDEVEKVLHP 287
Cdd:PRK07269 236 DSYLLMRGLKTLSLRMERSTANAQEVVAFLKKSPAVKEVLYT 277
|
|
| AAT_I |
cd01494 |
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ... |
79-212 |
1.17e-08 |
|
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).
Pssm-ID: 99742 [Multi-domain] Cd Length: 170 Bit Score: 53.93 E-value: 1.17e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 79 GTVLSASGLGSISLALLALSKAGDHILMTDSVYVPTRMlcDGLLAKFGV-------ETDYYDPSIGKDIEKLVKPNTTVI 151
Cdd:cd01494 19 KAVFVPSGTGANEAALLALLGPGDEVIVDANGHGSRYW--VAAELAGAKpvpvpvdDAGYGGLDVAILEELKAKPNVALI 96
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 768801298 152 FLESPGSGTMEVQDIPALVSVAKKHGIKTILDNTWATPLFFDA----HAHGIDISVEAGTKYLGG 212
Cdd:cd01494 97 VITPNTTSGGVLVPLKEIRKIAKEYGILLLVDAASAGGASPAPgvliPEGGADVVTFSLHKNLGG 161
|
|
| AAT_like |
cd00609 |
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
81-206 |
1.93e-08 |
|
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.
Pssm-ID: 99734 [Multi-domain] Cd Length: 350 Bit Score: 55.04 E-value: 1.93e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 81 VLSASGLGSISLALLALSKAGDHILMTDSVYVPTRMLCDGLLAKF-GVETDY--YDPSIGKDIEKLVKPNTTVIFLESPG 157
Cdd:cd00609 63 VVTNGAQEALSLLLRALLNPGDEVLVPDPTYPGYEAAARLAGAEVvPVPLDEegGFLLDLELLEAAKTPKTKLLYLNNPN 142
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 768801298 158 --SG-TMEVQDIPALVSVAKKHGIKTILDNTWAtPLFFDAHAHGIDISVEAG 206
Cdd:cd00609 143 npTGaVLSEEELEELAELAKKHGILIISDEAYA-ELVYDGEPPPALALLDAY 193
|
|
| SufS_like |
cd06453 |
Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP) ... |
89-212 |
4.38e-06 |
|
Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine; and selenocysteine lyase catalyzes the decomposition of L-selenocysteine.
Pssm-ID: 99746 [Multi-domain] Cd Length: 373 Bit Score: 47.85 E-value: 4.38e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 89 SISLALLALS---KAGDHILMT----DSVYVPTRMLCDgllaKFGVETDY--------YDPSigkDIEKLVKPNTTVIFL 153
Cdd:cd06453 73 AINLVAYGLGranKPGDEIVTSvmehHSNIVPWQQLAE----RTGAKLKVvpvdddgqLDLE---ALEKLLTERTKLVAV 145
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 768801298 154 eSPGS---GTmeVQDIPALVSVAKKHGIKTILDNTWATPLF-FDAHAHGIDISVEAGTKYLGG 212
Cdd:cd06453 146 -THVSnvlGT--INPVKEIGEIAHEAGVPVLVDGAQSAGHMpVDVQDLGCDFLAFSGHKMLGP 205
|
|
| CsdA |
COG0520 |
Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism]; |
91-200 |
8.28e-06 |
|
Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism];
Pssm-ID: 440286 [Multi-domain] Cd Length: 396 Bit Score: 47.06 E-value: 8.28e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 91 SLALLALS----KAGDHILMTD----SVYVPTRMLCDgllaKFGVE------TDYYDPSIgKDIEKLVKPNTTVIFLE-- 154
Cdd:COG0520 89 AINLVAYGlgrlKPGDEILITEmehhSNIVPWQELAE----RTGAEvrviplDEDGELDL-EALEALLTPRTKLVAVThv 163
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 768801298 155 SPGSGTmeVQDIPALVSVAKKHGIKTILDNTWATPLF-FDAHAHGID 200
Cdd:COG0520 164 SNVTGT--VNPVKEIAALAHAHGALVLVDGAQSVPHLpVDVQALGCD 208
|
|
| PRK07550 |
PRK07550 |
aminotransferase; |
92-186 |
5.57e-05 |
|
aminotransferase;
Pssm-ID: 181026 [Multi-domain] Cd Length: 386 Bit Score: 44.56 E-value: 5.57e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 92 LALLALSKAGDHILMTDSVYVPTRMLcdglLAKFGVETDYYDPSIGKD-------IEKLVKPNTTVIFLESPGSGTMEV- 163
Cdd:PRK07550 105 AAMVTLAGAGDEVILPLPWYFNHKMW----LDMLGIRPVYLPCDEGPGllpdpaaAEALITPRTRAIALVTPNNPTGVVy 180
|
90 100
....*....|....*....|....*
gi 768801298 164 --QDIPALVSVAKKHGIKTILDNTW 186
Cdd:PRK07550 181 ppELLHELYDLARRHGIALILDETY 205
|
|
| WecE |
COG0399 |
dTDP-4-amino-4,6-dideoxygalactose transaminase [Cell wall/membrane/envelope biogenesis]; |
51-216 |
6.08e-05 |
|
dTDP-4-amino-4,6-dideoxygalactose transaminase [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440168 Cd Length: 364 Bit Score: 44.29 E-value: 6.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 51 RKGRFygTAGsPTIDNLENAWTHLTGGAGTVLSASGLGSISLALLALS-KAGDHILMTDSVYVPT----RM------LCD 119
Cdd:COG0399 22 RSGWL--TLG-PEVKEFEEEFAAYLGVKHAVAVSSGTAALHLALRALGiGPGDEVITPAFTFVATanaiLYvgatpvFVD 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 120 gllakfgVETDYY--DPSigkDIEKLVKPNTTVIflespgsgtMEVQ------DIPALVSVAKKHGIKTILDNtwatplf 191
Cdd:COG0399 99 -------IDPDTYniDPE---ALEAAITPRTKAI---------IPVHlygqpaDMDAIMAIAKKHGLKVIEDA------- 152
|
170 180
....*....|....*....|....*
gi 768801298 192 fdAHAHGidisVEAGTKYLGGHSDL 216
Cdd:COG0399 153 --AQALG----ATYKGKKVGTFGDA 171
|
|
| PRK07568 |
PRK07568 |
pyridoxal phosphate-dependent aminotransferase; |
88-183 |
1.90e-04 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 181036 Cd Length: 397 Bit Score: 42.92 E-value: 1.90e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 88 GS--ISLALLALSKAGDHILMTDSVYVPTrmlcDGLLAKFGV---------ETDYYDPSIgKDIEKLVKPNTTVIFLESP 156
Cdd:PRK07568 97 GSeaILFAMMAICDPGDEILVPEPFYANY----NGFATSAGVkivpvttkiEEGFHLPSK-EEIEKLITPKTKAILISNP 171
|
90 100 110
....*....|....*....|....*....|
gi 768801298 157 GSGTMEV---QDIPALVSVAKKHGIKTILD 183
Cdd:PRK07568 172 GNPTGVVytkEELEMLAEIAKKHDLFLISD 201
|
|
| Aminotran_5 |
pfam00266 |
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes ... |
89-211 |
1.98e-04 |
|
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.
Pssm-ID: 425567 [Multi-domain] Cd Length: 368 Bit Score: 42.62 E-value: 1.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 89 SISLALLALS---KAGDHILMTD----SVYVPTRMLCDgllaKFGVETDY--------YDPSigkDIEKLVKPNTTVIFL 153
Cdd:pfam00266 73 AINLVALSLGrslKPGDEIVITEmehhANLVPWQELAK----RTGARVRVlpldedglLDLD---ELEKLITPKTKLVAI 145
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 768801298 154 eSPGS---GTmeVQDIPALVSVAKKHGIKTILDNTWATP-LFFDAHAHGIDISVEAGTKYLG 211
Cdd:pfam00266 146 -THVSnvtGT--IQPVPEIGKLAHQYGALVLVDAAQAIGhRPIDVQKLGVDFLAFSGHKLYG 204
|
|
| tyr_amTase_E |
TIGR01264 |
tyrosine aminotransferase, eukaryotic; This model describes tyrosine aminotransferase as found ... |
71-194 |
1.88e-03 |
|
tyrosine aminotransferase, eukaryotic; This model describes tyrosine aminotransferase as found in animals and Trypanosoma cruzi. It is the first enzyme of a pathway of tyrosine degradation via homogentisate. Several plant enzyme designated as probable tyrosine aminotransferases are very closely related to an experimentally demonstrated nicotianamine aminotransferase, an enzyme in a siderophore (iron uptake chelator) biosynthesis pathway. These plant sequences are excluded from the model seed and score between the trusted an noise cutoffs. [Energy metabolism, Amino acids and amines]
Pssm-ID: 273529 [Multi-domain] Cd Length: 401 Bit Score: 39.77 E-value: 1.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 71 WTHLTGG--AGTVLSASGLGS-ISLALLALSKAGDHILMTDSVYVPTRMLCDGLlakfGVETDYYDPSIGKD-------I 140
Cdd:TIGR01264 86 YHNPDGPieADDVVLCSGCSHaIEMCIAALANAGQNILVPRPGFPLYETLAESM----GIEVKLYNLLPDKSweidlkqL 161
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 768801298 141 EKLVKPNTTVIFLESPGSGTMEV---QDIPALVSVAKKHGIKTILDNTWATPLFFDA 194
Cdd:TIGR01264 162 ESLIDEKTAALIVNNPSNPCGSVfsrQHLEEILAVAERQCLPIIADEIYGDMVFSGA 218
|
|
| AGAT_like |
cd06451 |
Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate ... |
81-222 |
2.22e-03 |
|
Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT), serine-glyoxylate aminotransferase (SGAT), and 3-hydroxykynurenine transaminase (HKT). AGAT is a homodimeric protein, which catalyses the transamination of glyoxylate to glycine, and SGAT converts serine and glyoxylate to hydroxypyruvate and glycine. HKT catalyzes the PLP-dependent transamination of 3-hydroxykynurenine, a potentially toxic metabolite of the kynurenine pathway.
Pssm-ID: 99744 [Multi-domain] Cd Length: 356 Bit Score: 39.58 E-value: 2.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 81 VLSASGLGSISLALLALSKAGDHILMTDSVYVPTRMLcdGLLAKFGVETDYYDPSIGKDI------EKLVKPNTTVIFLE 154
Cdd:cd06451 54 LLSGSGTGAMEAALSNLLEPGDKVLVGVNGVFGDRWA--DMAERYGADVDVVEKPWGEAVspeeiaEALEQHDIKAVTLT 131
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 768801298 155 SPGSGTMEVQDIPALVSVAKKHGIKTILD---NTWATPLFFDahAHGIDISVEAGTKYLGGHSDLLIGLAS 222
Cdd:cd06451 132 HNETSTGVLNPLEGIGALAKKHDALLIVDavsSLGGEPFRMD--EWGVDVAYTGSQKALGAPPGLGPIAFS 200
|
|
| tyr_nico_aTase |
TIGR01265 |
tyrosine/nicotianamine family aminotransferase; This subfamily of pyridoxal ... |
81-194 |
4.69e-03 |
|
tyrosine/nicotianamine family aminotransferase; This subfamily of pyridoxal phosphate-dependent enzymes includes known examples of both tyrosine aminotransferase from animals and nicotianamine aminotransferase from barley.
Pssm-ID: 188123 Cd Length: 403 Bit Score: 38.48 E-value: 4.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768801298 81 VLSASGLGSISLALLALSKAGDHILmtdsVYVPTRMLCDGLLAKFGVETDYYDPSIGKD-------IEKLVKPNTTVIFL 153
Cdd:TIGR01265 100 VLTSGCSQAIEICIEALANPGANIL----VPRPGFPLYDTRAAFSGLEVRLYDLLPEKDweidldgLESLADEKTVAIVV 175
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 768801298 154 ESPGSGTMEV---QDIPALVSVAKKHGIKTILDNTWATPLFFDA 194
Cdd:TIGR01265 176 INPSNPCGSVfsrDHLQKIAEVAEKLGIPIIADEIYGHMVFGDA 219
|
|
| |
