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Conserved domains on  [gi|768811323|gb|AJV27927|]
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Bat1p [Saccharomyces cerevisiae YJM1190]

Protein Classification

branched-chain amino acid aminotransferase( domain architecture ID 10107512)

branched-chain amino acid aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-ketoisovalerate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BCAT_beta_family cd01557
BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the ...
 78-378 1.55e-134

BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-ketoisovalerate. The enzyme requires pyridoxal 5'-phosphate (PLP) as a cofactor to catalyze the reaction. It has been found that mammals have two foms of the enzyme - mitochondrial and cytosolic forms while bacteria contain only one form of the enzyme. The mitochondrial form plays a significant role in skeletal muscle glutamine and alanine synthesis and in interorgan nitrogen metabolism.Members of this subgroup are widely distributed in all three forms of life.


:

Pssm-ID: 238798  Cd Length: 279  Bit Score: 386.17  E-value: 1.55e-134
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323  78 SLDPSACVFHYAFELFEGLKAYRTPQNTITMFRPDKNMARMNKSAARICLPTFESEELIKLTGKLIEQDKHLVPQGNGYS 157
Cdd:cd01557    1 SLHPATHALHYGQAVFEGLKAYRTPDGKIVLFRPDENAERLNRSARRLGLPPFSVEEFIDAIKELVKLDADWVPYGGGAS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323 158 LYIRPTMIGTSKGLGVGTPSEALLYVITSPVGPYYKTGFKAVRLEATDYaTRAWPGGVGDKKLGANYAPCILPQLQAAKR 237
Cdd:cd01557   81 LYIRPFIFGTDPQLGVSPALEYLFAVFASPVGAYFKGGEKGVSALVSSF-RRAAPGGPGAAKAGGNYAASLLAQKEAAEK 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323 238 GYQQNLWLFGPEKNITEVGTMNVFFVFlnkvtgKKELVTAPLDGTILEGVTRDSVLTLARDKldpqEWDINERYYTITEV 317
Cdd:cd01557  160 GYDQALWLDGAHGYVAEVGTMNIFFVK------DGELITPPLDGSILPGITRDSILELARDL----GIKVEERPITRDEL 229

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 768811323 318 AtrakqgELLEAFGSGTAAVVSPIKEIGWNNEDIhvpllPGEQCGALTKQVAQWIADIQYG 378
Cdd:cd01557  230 Y------EADEVFATGTAAVVTPVGEIDYRGKEP-----GEGEVGPVTKKLYDLLTDIQYG 279
 
Name Accession Description Interval E-value
BCAT_beta_family cd01557
BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the ...
 78-378 1.55e-134

BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-ketoisovalerate. The enzyme requires pyridoxal 5'-phosphate (PLP) as a cofactor to catalyze the reaction. It has been found that mammals have two foms of the enzyme - mitochondrial and cytosolic forms while bacteria contain only one form of the enzyme. The mitochondrial form plays a significant role in skeletal muscle glutamine and alanine synthesis and in interorgan nitrogen metabolism.Members of this subgroup are widely distributed in all three forms of life.


Pssm-ID: 238798  Cd Length: 279  Bit Score: 386.17  E-value: 1.55e-134
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323  78 SLDPSACVFHYAFELFEGLKAYRTPQNTITMFRPDKNMARMNKSAARICLPTFESEELIKLTGKLIEQDKHLVPQGNGYS 157
Cdd:cd01557    1 SLHPATHALHYGQAVFEGLKAYRTPDGKIVLFRPDENAERLNRSARRLGLPPFSVEEFIDAIKELVKLDADWVPYGGGAS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323 158 LYIRPTMIGTSKGLGVGTPSEALLYVITSPVGPYYKTGFKAVRLEATDYaTRAWPGGVGDKKLGANYAPCILPQLQAAKR 237
Cdd:cd01557   81 LYIRPFIFGTDPQLGVSPALEYLFAVFASPVGAYFKGGEKGVSALVSSF-RRAAPGGPGAAKAGGNYAASLLAQKEAAEK 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323 238 GYQQNLWLFGPEKNITEVGTMNVFFVFlnkvtgKKELVTAPLDGTILEGVTRDSVLTLARDKldpqEWDINERYYTITEV 317
Cdd:cd01557  160 GYDQALWLDGAHGYVAEVGTMNIFFVK------DGELITPPLDGSILPGITRDSILELARDL----GIKVEERPITRDEL 229

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 768811323 318 AtrakqgELLEAFGSGTAAVVSPIKEIGWNNEDIhvpllPGEQCGALTKQVAQWIADIQYG 378
Cdd:cd01557  230 Y------EADEVFATGTAAVVTPVGEIDYRGKEP-----GEGEVGPVTKKLYDLLTDIQYG 279
PRK13357 PRK13357
branched-chain amino acid aminotransferase; Provisional
 29-380 1.26e-132

branched-chain amino acid aminotransferase; Provisional


Pssm-ID: 237363  Cd Length: 356  Bit Score: 384.11  E-value: 1.26e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323  29 KITRNPNPSKPRPNEE----LVFGQTFTDHMLTIPWSAEEgWGTPHIKPYGNLSLDPSACVFHYAFELFEGLKAYRTPQN 104
Cdd:PRK13357   2 TVTLKPNPTSDEKRAIdwanLGFGYVFTDHMVVIDYKDGK-WHDARLVPYGPLELDPAATVLHYGQEIFEGLKAYRHKDG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323 105 TITMFRPDKNMARMNKSAARICLPTFESEELIKLTGKLIEQDKHLV-PQGNGYSLYIRPTMIGTSKGLGVGTPSEALLYV 183
Cdd:PRK13357  81 SIVLFRPDANAKRLQRSADRLLMPELPEELFLEAVKQLVKADRDWVpPYGEGASLYLRPFMIATEPFLGVKPAEEYIFCV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323 184 ITSPVGPYYKTGFKAVR-LEATDYaTRAWPGGVGDKKLGANYAPCILPQLQAAKRGYQQNLWLFGPE-KNITEVGTMNVF 261
Cdd:PRK13357 161 IASPVGAYFKGGVKPVSiWVSDEY-DRAAPGGTGAAKVGGNYAASLLAQAEAKEKGCDQVLYLDAVEhTYIEEVGGMNFF 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323 262 FVFlnkvtgKKELVTAPLDGTILEGVTRDSVLTLARDkldpqeWDIN--ERYYTITEVATRAKQGELLEAFGSGTAAVVS 339
Cdd:PRK13357 240 FIT------KDGTVTPPLSGSILPGITRDSLLQLAED------LGLTveERPVSIDEWQADAASGEFTEAFACGTAAVIT 307

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 768811323 340 PIKEIGWNNEDIHVpllPGEQCGALTKQVAQWIADIQYGRV 380
Cdd:PRK13357 308 PIGGIKYKDKEFVI---GDGEVGPVTQKLYDELTGIQFGDV 345
ilvE_II TIGR01123
branched-chain amino acid aminotransferase, group II; Among the class IV aminotransferases are ...
 66-380 8.85e-96

branched-chain amino acid aminotransferase, group II; Among the class IV aminotransferases are two phylogenetically separable groups of branched-chain amino acid aminotransferase (IlvE). The last common ancestor of the two lineages appears also to have given rise to a family of D-amino acid aminotransferases (DAAT). This model represents the IlvE family less similar to the DAAT family. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 233278  Cd Length: 313  Bit Score: 288.58  E-value: 8.85e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323   66 WGTPHIKPYGNLSLDPSACVFHYAFELFEGLKAYRTPQNTITMFRPDKNMARMNKSAARICLPTFESEELIKLTGKLIEQ 145
Cdd:TIGR01123   1 WHNGRLTPYGPLHLDPGSTVLHYGQECFEGLKAYRCADGSIVLFRPDANAARLRRSARRLLMPELPDELFLEALRQLVKA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323  146 DKHLVP-QGNGYSLYIRPTMIGTSKGLGVGTPSEALLYVITSPVGPYYKTGFKAVRLEATDYATRAWPGGVGDKKLGANY 224
Cdd:TIGR01123  81 NKDWVPpYGSGASLYLRPFVIGTEPNLGVRPAPEYLFYVFASPVGAYFKGGLAPVSIFVTTEYDRAAPGGTGAVKVGGNY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323  225 APCILPQLQAAKRGYQQNLWLFGPE-KNITEVGTMNVFFvflnkVTGKKELVTAPLDGTILEGVTRDSVLTLARDKLDPQ 303
Cdd:TIGR01123 161 AASLLAQAKAAEQGCDQVVYLDPVEhTYIEEVGAMNFFF-----ITGDGELVTPPLSGSILPGITRDSLLQLAKDLGMEV 235

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 768811323  304 EwdinERYYTITEVATRAKQGEllEAFGSGTAAVVSPIKEIGWNNEDIHVpllPGEQCGALTKQVAQWIADIQYGRV 380
Cdd:TIGR01123 236 E----ERRIDIDELKAFVEAGE--IVFACGTAAVITPVGEIQHGGKEVVF---ASGQPGEVTKALYDELTDIQYGDF 303
IlvE COG0115
Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid ...
 66-380 1.54e-71

Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


Pssm-ID: 439885 [Multi-domain]  Cd Length: 285  Bit Score: 225.45  E-value: 1.54e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323  66 WGTPHIKPYGNLSLDPSACVFHYAFELFEGLKAYRTPqntitMFRPDKNMARMNKSAARICLP-TFESEELIKLTGKLIE 144
Cdd:COG0115    4 WLNGELVPEEEATISVLDRGLHYGDGVFEGIRAYDGR-----LFRLDEHLARLNRSAKRLGIPiPYTEEELLEAIRELVA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323 145 QDKHLvpqgngySLYIRPTMIGTSKGLGVGTP-SEALLYVITSPVGPYYKTGF-KAVRLEATDYaTRAWPGGVGDKKlGA 222
Cdd:COG0115   79 ANGLE-------DGYIRPQVTRGVGGRGVFAEeYEPTVIIIASPLPAYPAEAYeKGVRVITSPY-RRAAPGGLGGIK-TG 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323 223 NYAPCILPQLQAAKRGYQQNLWLfGPEKNITEVGTMNVFFVFlnkvtgKKELVTAPLDGTILEGVTRDSVLTLARDkldp 302
Cdd:COG0115  150 NYLNNVLAKQEAKEAGADEALLL-DTDGYVAEGSGSNVFIVK------DGVLVTPPLSGGILPGITRDSVIELARE---- 218

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 768811323 303 QEWDINERYYTITEVATrAKqgellEAFGSGTAAVVSPIKEIGwnneDIHVpllPGEQCGALTKQVAQWIADIQYGRV 380
Cdd:COG0115  219 LGIPVEERPISLEELYT-AD-----EVFLTGTAAEVTPVTEID----GRPI---GDGKPGPVTRRLRELYTDIVRGEA 283
Aminotran_4 pfam01063
Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to ...
 92-344 2.51e-30

Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to catalyze the synthesis of D-glutamic acid and D-alanine, which are essential constituents of bacterial cell wall and are the building block for other D-amino acids. Despite the difference in the structure of the substrates, D-AATs and L-ATTs have strong similarity.


Pssm-ID: 395844 [Multi-domain]  Cd Length: 221  Bit Score: 115.92  E-value: 2.51e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323   92 LFEGLKAYRtpqNTItmFRPDKNMARMNKSAARICLPTFESEELIKltgKLIEQdkhLVPQGNGYSLYIRPTMIGTSKGL 171
Cdd:pfam01063   2 VFETLRVYN---GKI--FFLDEHLARLRRSAKLLGIPLPFDEEDLR---KIIEE---LLKANGLGVGRLRLTVSRGPGGF 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323  172 GVGTPS-EALLYVITSPVGPYYKtgfkavRLEATDYATRAWPGGVGDKKLGANYAPCILPQLQAAKRGYQQNLwLFGPEK 250
Cdd:pfam01063  71 GLPTSDpTLAIFVSALPPPPESK------KKGVISSLVRRNPPSPLPGAKTLNYLENVLARREAKAQGADDAL-LLDEDG 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323  251 NITEVGTMNVFFVflnkvtgK-KELVTAPLDGTILEGVTRDSVLTLARdkldPQEWDINERYYTITEVAtRAKqgellEA 329
Cdd:pfam01063 144 NVTEGSTSNVFLV-------KgGTLYTPPLESGILPGITRQALLDLAK----ALGLEVEERPITLADLQ-EAD-----EA 206

                         250
                  ....*....|....*
gi 768811323  330 FGSGTAAVVSPIKEI 344
Cdd:pfam01063 207 FLTNSLRGVTPVSSI 221
 
Name Accession Description Interval E-value
BCAT_beta_family cd01557
BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the ...
 78-378 1.55e-134

BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-ketoisovalerate. The enzyme requires pyridoxal 5'-phosphate (PLP) as a cofactor to catalyze the reaction. It has been found that mammals have two foms of the enzyme - mitochondrial and cytosolic forms while bacteria contain only one form of the enzyme. The mitochondrial form plays a significant role in skeletal muscle glutamine and alanine synthesis and in interorgan nitrogen metabolism.Members of this subgroup are widely distributed in all three forms of life.


Pssm-ID: 238798  Cd Length: 279  Bit Score: 386.17  E-value: 1.55e-134
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323  78 SLDPSACVFHYAFELFEGLKAYRTPQNTITMFRPDKNMARMNKSAARICLPTFESEELIKLTGKLIEQDKHLVPQGNGYS 157
Cdd:cd01557    1 SLHPATHALHYGQAVFEGLKAYRTPDGKIVLFRPDENAERLNRSARRLGLPPFSVEEFIDAIKELVKLDADWVPYGGGAS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323 158 LYIRPTMIGTSKGLGVGTPSEALLYVITSPVGPYYKTGFKAVRLEATDYaTRAWPGGVGDKKLGANYAPCILPQLQAAKR 237
Cdd:cd01557   81 LYIRPFIFGTDPQLGVSPALEYLFAVFASPVGAYFKGGEKGVSALVSSF-RRAAPGGPGAAKAGGNYAASLLAQKEAAEK 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323 238 GYQQNLWLFGPEKNITEVGTMNVFFVFlnkvtgKKELVTAPLDGTILEGVTRDSVLTLARDKldpqEWDINERYYTITEV 317
Cdd:cd01557  160 GYDQALWLDGAHGYVAEVGTMNIFFVK------DGELITPPLDGSILPGITRDSILELARDL----GIKVEERPITRDEL 229

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 768811323 318 AtrakqgELLEAFGSGTAAVVSPIKEIGWNNEDIhvpllPGEQCGALTKQVAQWIADIQYG 378
Cdd:cd01557  230 Y------EADEVFATGTAAVVTPVGEIDYRGKEP-----GEGEVGPVTKKLYDLLTDIQYG 279
PRK13357 PRK13357
branched-chain amino acid aminotransferase; Provisional
 29-380 1.26e-132

branched-chain amino acid aminotransferase; Provisional


Pssm-ID: 237363  Cd Length: 356  Bit Score: 384.11  E-value: 1.26e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323  29 KITRNPNPSKPRPNEE----LVFGQTFTDHMLTIPWSAEEgWGTPHIKPYGNLSLDPSACVFHYAFELFEGLKAYRTPQN 104
Cdd:PRK13357   2 TVTLKPNPTSDEKRAIdwanLGFGYVFTDHMVVIDYKDGK-WHDARLVPYGPLELDPAATVLHYGQEIFEGLKAYRHKDG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323 105 TITMFRPDKNMARMNKSAARICLPTFESEELIKLTGKLIEQDKHLV-PQGNGYSLYIRPTMIGTSKGLGVGTPSEALLYV 183
Cdd:PRK13357  81 SIVLFRPDANAKRLQRSADRLLMPELPEELFLEAVKQLVKADRDWVpPYGEGASLYLRPFMIATEPFLGVKPAEEYIFCV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323 184 ITSPVGPYYKTGFKAVR-LEATDYaTRAWPGGVGDKKLGANYAPCILPQLQAAKRGYQQNLWLFGPE-KNITEVGTMNVF 261
Cdd:PRK13357 161 IASPVGAYFKGGVKPVSiWVSDEY-DRAAPGGTGAAKVGGNYAASLLAQAEAKEKGCDQVLYLDAVEhTYIEEVGGMNFF 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323 262 FVFlnkvtgKKELVTAPLDGTILEGVTRDSVLTLARDkldpqeWDIN--ERYYTITEVATRAKQGELLEAFGSGTAAVVS 339
Cdd:PRK13357 240 FIT------KDGTVTPPLSGSILPGITRDSLLQLAED------LGLTveERPVSIDEWQADAASGEFTEAFACGTAAVIT 307

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 768811323 340 PIKEIGWNNEDIHVpllPGEQCGALTKQVAQWIADIQYGRV 380
Cdd:PRK13357 308 PIGGIKYKDKEFVI---GDGEVGPVTQKLYDELTGIQFGDV 345
ilvE_II TIGR01123
branched-chain amino acid aminotransferase, group II; Among the class IV aminotransferases are ...
 66-380 8.85e-96

branched-chain amino acid aminotransferase, group II; Among the class IV aminotransferases are two phylogenetically separable groups of branched-chain amino acid aminotransferase (IlvE). The last common ancestor of the two lineages appears also to have given rise to a family of D-amino acid aminotransferases (DAAT). This model represents the IlvE family less similar to the DAAT family. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 233278  Cd Length: 313  Bit Score: 288.58  E-value: 8.85e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323   66 WGTPHIKPYGNLSLDPSACVFHYAFELFEGLKAYRTPQNTITMFRPDKNMARMNKSAARICLPTFESEELIKLTGKLIEQ 145
Cdd:TIGR01123   1 WHNGRLTPYGPLHLDPGSTVLHYGQECFEGLKAYRCADGSIVLFRPDANAARLRRSARRLLMPELPDELFLEALRQLVKA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323  146 DKHLVP-QGNGYSLYIRPTMIGTSKGLGVGTPSEALLYVITSPVGPYYKTGFKAVRLEATDYATRAWPGGVGDKKLGANY 224
Cdd:TIGR01123  81 NKDWVPpYGSGASLYLRPFVIGTEPNLGVRPAPEYLFYVFASPVGAYFKGGLAPVSIFVTTEYDRAAPGGTGAVKVGGNY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323  225 APCILPQLQAAKRGYQQNLWLFGPE-KNITEVGTMNVFFvflnkVTGKKELVTAPLDGTILEGVTRDSVLTLARDKLDPQ 303
Cdd:TIGR01123 161 AASLLAQAKAAEQGCDQVVYLDPVEhTYIEEVGAMNFFF-----ITGDGELVTPPLSGSILPGITRDSLLQLAKDLGMEV 235

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 768811323  304 EwdinERYYTITEVATRAKQGEllEAFGSGTAAVVSPIKEIGWNNEDIHVpllPGEQCGALTKQVAQWIADIQYGRV 380
Cdd:TIGR01123 236 E----ERRIDIDELKAFVEAGE--IVFACGTAAVITPVGEIQHGGKEVVF---ASGQPGEVTKALYDELTDIQYGDF 303
PLPDE_IV cd00449
PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, ...
 85-372 1.32e-79

PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate lyases (ADCL). BCAT catalyzes the reversible transamination reaction between the L-branched-chain amino and alpha-keto acids. DAAT catalyzes the synthesis of D-glutamic acid and D-alanine, and ADCL converts 4-amino-4-deoxychorismate to p-aminobenzoate and pyruvate. Except for a few enzymes, i. e., Escherichia coli and Salmonella BCATs, which are homohexamers arranged as a double trimer, the class IV PLPDEs are homodimers. Homodimer formation is required for catalytic activity.


Pssm-ID: 238254 [Multi-domain]  Cd Length: 256  Bit Score: 245.20  E-value: 1.32e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323  85 VFHYAFELFEGLKAYRtpqntITMFRPDKNMARMNKSAARICLP-TFESEELIKLTGKLIEQdkhlvpqGNGYSLYIRPT 163
Cdd:cd00449    3 GLHYGDGVFEGLRAGK-----GRLFRLDEHLDRLNRSAKRLGLPiPYDREELREALKELVAA-------NNGASLYIRPL 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323 164 MIGTSKGLGVGTP--SEALLYVITSPVGPYYKTGFKAVRLEATDYATRAWPGGVGDKKLGaNYAPCILPQLQAAKRGYQQ 241
Cdd:cd00449   71 LTRGVGGLGVAPPpsPEPTFVVFASPVGAYAKGGEKGVRLITSPDRRRAAPGGTGDAKTG-GNLNSVLAKQEAAEAGADE 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323 242 NLWLFGpEKNITEVGTMNVFFVFlnkvtgKKELVTAPLDGTILEGVTRDSVLTLARDKLdpqeWDINERYYTITEVAtra 321
Cdd:cd00449  150 ALLLDD-NGYVTEGSASNVFIVK------DGELVTPPLDGGILPGITRDSVIELAKELG----IKVEERPISLDELY--- 215

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 768811323 322 kqgELLEAFGSGTAAVVSPIKEIGWNNEdihvpllPGEQCGALTKQVAQWI 372
Cdd:cd00449  216 ---AADEVFLTGTAAEVTPVTEIDGRGI-------GDGKPGPVTRKLRELL 256
IlvE COG0115
Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid ...
 66-380 1.54e-71

Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


Pssm-ID: 439885 [Multi-domain]  Cd Length: 285  Bit Score: 225.45  E-value: 1.54e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323  66 WGTPHIKPYGNLSLDPSACVFHYAFELFEGLKAYRTPqntitMFRPDKNMARMNKSAARICLP-TFESEELIKLTGKLIE 144
Cdd:COG0115    4 WLNGELVPEEEATISVLDRGLHYGDGVFEGIRAYDGR-----LFRLDEHLARLNRSAKRLGIPiPYTEEELLEAIRELVA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323 145 QDKHLvpqgngySLYIRPTMIGTSKGLGVGTP-SEALLYVITSPVGPYYKTGF-KAVRLEATDYaTRAWPGGVGDKKlGA 222
Cdd:COG0115   79 ANGLE-------DGYIRPQVTRGVGGRGVFAEeYEPTVIIIASPLPAYPAEAYeKGVRVITSPY-RRAAPGGLGGIK-TG 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323 223 NYAPCILPQLQAAKRGYQQNLWLfGPEKNITEVGTMNVFFVFlnkvtgKKELVTAPLDGTILEGVTRDSVLTLARDkldp 302
Cdd:COG0115  150 NYLNNVLAKQEAKEAGADEALLL-DTDGYVAEGSGSNVFIVK------DGVLVTPPLSGGILPGITRDSVIELARE---- 218

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 768811323 303 QEWDINERYYTITEVATrAKqgellEAFGSGTAAVVSPIKEIGwnneDIHVpllPGEQCGALTKQVAQWIADIQYGRV 380
Cdd:COG0115  219 LGIPVEERPISLEELYT-AD-----EVFLTGTAAEVTPVTEID----GRPI---GDGKPGPVTRRLRELYTDIVRGEA 283
PLN03117 PLN03117
Branched-chain-amino-acid aminotransferase; Provisional
 43-380 2.13e-59

Branched-chain-amino-acid aminotransferase; Provisional


Pssm-ID: 178664  Cd Length: 355  Bit Score: 196.69  E-value: 2.13e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323  43 EELVFGQTFTDHMLTIPWSAEEGWGTPHIKPYGNLSLDPSACVFHYAFELFEGLKAYRTPQNTITMFRPDKNMARMNKSA 122
Cdd:PLN03117  23 EELGFALVPTDYMYVAKCKQGESFSEGKIVPYGDISISPCAGILNYGQGLFEGLKAYRTEDGRITLFRPDQNALRMQTGA 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323 123 ARICLPTFESEELIKLTGKLIEQDKHLVPQGNGYSLYIRPTMIGTSKGLGVGTPSEALLYVITSPVGPYYKTGfKAVRLE 202
Cdd:PLN03117 103 DRLCMTPPSLEQFVEAVKQTVLANKKWVPPPGKGTLYIRPLLIGSGAVLGVAPAPEYTFLIYASPVGNYHKAS-SGLNLK 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323 203 ATDYATRAWPGGVGDKKLGANYAPCILPQLQAAKRGYQQNLWLFGPE-KNITEVGTMNVFFVFLNKVTgkkelvTAPLDG 281
Cdd:PLN03117 182 VDHKHRRAHSGGTGGVKSCTNYSPVVKSLIEAKSSGFSDVLFLDAATgKNIEELSACNIFILKGNIVS------TPPTSG 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323 282 TILEGVTRDSVLTLARDKldpqEWDINERYYTITEVAtrakqgELLEAFGSGTAAVVSPIKEIGWNneDIHVPLLPGEQc 361
Cdd:PLN03117 256 TILPGVTRKSISELARDI----GYQVEERDVSVDELL------EAEEVFCTGTAVVVKAVETVTFH--DKKVKYRTGEE- 322

                        330
                 ....*....|....*....
gi 768811323 362 gALTKQVAQWIADIQYGRV 380
Cdd:PLN03117 323 -ALSTKLHLILTNIQMGVV 340
PLN02782 PLN02782
Branched-chain amino acid aminotransferase
 43-386 2.60e-53

Branched-chain amino acid aminotransferase


Pssm-ID: 215418  Cd Length: 403  Bit Score: 181.97  E-value: 2.60e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323  43 EELVFGQTFTDHMLTIPWSAEEGWGTPHIKPYGNLSLDPSACVFHYAFELFEGLKAYRTPQNTITMFRPDKNMARMNKSA 122
Cdd:PLN02782  73 DNLGFGLVPTDYMYIMKCNRDGEFSKGELQRFGNIELSPSAGVLNYGQGLFEGLKAYRKEDGNILLFRPEENAIRMRNGA 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323 123 ARICLPTFESEELIKLTGKLIEQDKHLVPQGNGYSLYIRPTMIGTSKGLGVGTPSEALLYVITSPVGPYYKTGFKAVRLE 202
Cdd:PLN02782 153 ERMCMPAPTVEQFVEAVKETVLANKRWVPPPGKGSLYIRPLLMGSGAVLGLAPAPEYTFLIYVSPVGNYFKEGVAPINLI 232

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323 203 ATDYATRAWPGGVGDKKLGANYAPCILPQLQAAKRGYQQNLWLFGPEKN-ITEVGTMNVFFVFLNKVTgkkelvTAPLDG 281
Cdd:PLN02782 233 VENEFHRATPGGTGGVKTIGNYAAVLKAQSIAKAKGYSDVLYLDCVHKKyLEEVSSCNIFIVKDNVIS------TPAIKG 306

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323 282 TILEGVTRDSVLTLARDkldpQEWDINERYYTITevatrakqgELLEA---FGSGTAAVVSPIKEIGWNNEDIHVpllpG 358
Cdd:PLN02782 307 TILPGITRKSIIDVARS----QGFQVEERNVTVD---------ELLEAdevFCTGTAVVVSPVGSITYKGKRVSY----G 369

                        330       340       350
                 ....*....|....*....|....*....|
gi 768811323 359 EQ-CGALTKQVAQWIADIQYGRV-NYGNWS 386
Cdd:PLN02782 370 EGgFGTVSQQLYTVLTSLQMGLIeDNMNWT 399
PLN02259 PLN02259
branched-chain-amino-acid aminotransferase 2
 14-351 7.22e-49

branched-chain-amino-acid aminotransferase 2


Pssm-ID: 177901  Cd Length: 388  Bit Score: 169.90  E-value: 7.22e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323  14 IRTLATGAPLDASKLKITRNPNPSKPRPN----------EELVFGQTFTDHMLTIPWSAEEGWGTPHIKPYGNLSLDPSA 83
Cdd:PLN02259  20 IRTLQTFAKYNAQAASALREERKKPLYQNgddvyadldwDNLGFGLNPADYMYVMKCSKDGEFTQGELSPYGNIQLSPSA 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323  84 CVFHYAFELFEGLKAYRTPQNTITMFRPDKNMARMNKSAARICLPTFESEELIKLTGKLIEQDKHLVPQGNGYSLYIRPT 163
Cdd:PLN02259 100 GVLNYGQAIYEGTKAYRKENGKLLLFRPDHNAIRMKLGAERMLMPSPSVDQFVNAVKQTALANKRWVPPAGKGTLYIRPL 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323 164 MIGTSKGLGVGTPSEALLYVITSPVGPYYKTGFKAVRLEATDYATRAWPGGVGDKKLGANYAPCILPQLQAAKRGYQQNL 243
Cdd:PLN02259 180 LMGSGPILGLGPAPEYTFIVYASPVGNYFKEGMAALNLYVEEEYVRAAPGGAGGVKSITNYAPVLKALSRAKSRGFSDVL 259

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323 244 WLFGPEKN-ITEVGTMNVFfvflnkVTGKKELVTAPLDGTILEGVTRDSVLTLARDkldpQEWDINERYYTITEVAtrak 322
Cdd:PLN02259 260 YLDSVKKKyLEEASSCNVF------VVKGRTISTPATNGTILEGITRKSVMEIASD----QGYQVVEKAVHVDEVM---- 325

                        330       340
                 ....*....|....*....|....*....
gi 768811323 323 qgELLEAFGSGTAAVVSPIKEIGWNNEDI 351
Cdd:PLN02259 326 --DADEVFCTGTAVVVAPVGTITYQEKRV 352
PLN02883 PLN02883
Branched-chain amino acid aminotransferase
 43-390 2.84e-44

Branched-chain amino acid aminotransferase


Pssm-ID: 178471  Cd Length: 384  Bit Score: 157.57  E-value: 2.84e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323  43 EELVFGQTFTDHMLTIPWSAEEGWGTPHIKPYGNLSLDPSACVFHYAFELFEGLKAYRTPQNTITMFRPDKNMARMNKSA 122
Cdd:PLN02883  55 DKLGFSLVRTDFMFATKSCRDGNFEQGYLSRYGNIELNPAAGILNYGQGLIEGMKAYRGEDGRILLFRPELNAMRMKIGA 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323 123 ARICLPTFESEELIKLTGKLIEQDKHLVPQGNGYSLYIRPTMIGTSKGLGVGTPSEALLYVITSPVGPYYKTGFKAVRLE 202
Cdd:PLN02883 135 ERMCMHSPSVHQFIEGVKQTVLANRRWVPPPGKGSLYLRPLLFGSGASLGVAAAPEYTFLVFGSPVQNYFKEGTAALNLY 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323 203 ATDYATRAWPGGVGDKKLGANYAPCILPQLQAAKRGYQQNLWLFGPE-KNITEVGTMNVFFVFLNKVtgkkelVTAPLDG 281
Cdd:PLN02883 215 VEEVIPRAYLGGTGGVKAISNYGPVLEVMRRAKSRGFSDVLYLDADTgKNIEEVSAANIFLVKGNII------VTPATSG 288

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323 282 TILEGVTRDSVLTLARDkldpQEWDINERYYTITEVatraKQGEllEAFGSGTAAVVSPIKEIGWNNEDIHVPLlpGEqc 361
Cdd:PLN02883 289 TILGGITRKSIIEIALD----LGYKVEERRVPVEEL----KEAE--EVFCTGTAAGVASVGSITFKNTRTEYKV--GD-- 354

                        330       340       350
                 ....*....|....*....|....*....|
gi 768811323 362 GALTKQVAQWIADIQYGRV-NYGNWSKTVA 390
Cdd:PLN02883 355 GIVTQQLRSILLGIQTGSIqDTKDWVLQIA 384
Aminotran_4 pfam01063
Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to ...
 92-344 2.51e-30

Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to catalyze the synthesis of D-glutamic acid and D-alanine, which are essential constituents of bacterial cell wall and are the building block for other D-amino acids. Despite the difference in the structure of the substrates, D-AATs and L-ATTs have strong similarity.


Pssm-ID: 395844 [Multi-domain]  Cd Length: 221  Bit Score: 115.92  E-value: 2.51e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323   92 LFEGLKAYRtpqNTItmFRPDKNMARMNKSAARICLPTFESEELIKltgKLIEQdkhLVPQGNGYSLYIRPTMIGTSKGL 171
Cdd:pfam01063   2 VFETLRVYN---GKI--FFLDEHLARLRRSAKLLGIPLPFDEEDLR---KIIEE---LLKANGLGVGRLRLTVSRGPGGF 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323  172 GVGTPS-EALLYVITSPVGPYYKtgfkavRLEATDYATRAWPGGVGDKKLGANYAPCILPQLQAAKRGYQQNLwLFGPEK 250
Cdd:pfam01063  71 GLPTSDpTLAIFVSALPPPPESK------KKGVISSLVRRNPPSPLPGAKTLNYLENVLARREAKAQGADDAL-LLDEDG 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323  251 NITEVGTMNVFFVflnkvtgK-KELVTAPLDGTILEGVTRDSVLTLARdkldPQEWDINERYYTITEVAtRAKqgellEA 329
Cdd:pfam01063 144 NVTEGSTSNVFLV-------KgGTLYTPPLESGILPGITRQALLDLAK----ALGLEVEERPITLADLQ-EAD-----EA 206

                         250
                  ....*....|....*
gi 768811323  330 FGSGTAAVVSPIKEI 344
Cdd:pfam01063 207 FLTNSLRGVTPVSSI 221
PRK06606 PRK06606
branched-chain amino acid transaminase;
86-385 9.54e-27

branched-chain amino acid transaminase;


Pssm-ID: 235841  Cd Length: 306  Bit Score: 108.31  E-value: 9.54e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323  86 FHYAFELFEGLKAYRTPQNTiTMFRPDKNMARMNKSAA--RICLPtFESEELIKLTGKLIEQdkhlvpqgNGY-SLYIRP 162
Cdd:PRK06606  30 LHYGTGVFEGIRAYDTPKGP-AIFRLREHTKRLFNSAKilRMEIP-YSVDELMEAQREVVRK--------NNLkSAYIRP 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323 163 -TMIGtSKGLGV---GTPSEALLYVItsPVGPY-----YKTGFKA-----VRLEATDYATRAwpggvgdkKLGANYAPCI 228
Cdd:PRK06606 100 lVFVG-DEGLGVrphGLPTDVAIAAW--PWGAYlgeeaLEKGIRVkvsswTRHAPNSIPTRA--------KASGNYLNSI 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323 229 LPQLQAAKRGYQQNLwLFGPEKNITEVGTMNVFFVflnkvtGKKELVTAPLDGTILEGVTRDSVLTLARDkldpqewdin 308
Cdd:PRK06606 169 LAKTEARRNGYDEAL-LLDVEGYVSEGSGENIFIV------RDGVLYTPPLTSSILEGITRDTVITLAKD---------- 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323 309 eRYYTITEvaTRAKQGELL---EAFGSGTAAVVSPIKEIgwnneDIHVplLPGEQCGALTKQVAQWIADIQYGRV-NYGN 384
Cdd:PRK06606 232 -LGIEVIE--RRITRDELYiadEVFFTGTAAEVTPIREV-----DGRQ--IGNGKRGPITEKLQSAYFDIVRGRTeKYAH 301


                 .
gi 768811323 385 W 385
Cdd:PRK06606 302 W 302
ilvE_I TIGR01122
branched-chain amino acid aminotransferase, group I; Among the class IV aminotransferases are ...
 85-385 2.22e-26

branched-chain amino acid aminotransferase, group I; Among the class IV aminotransferases are two phylogenetically separable groups of branched-chain amino acid aminotransferase (IlvE). The last common ancestor of the two lineages appears also to have given rise to a family of D-amino acid aminotransferases (DAAT). This model represents the IlvE family more strongly similar to the DAAT family. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 130192  Cd Length: 298  Bit Score: 107.06  E-value: 2.22e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323   85 VFHYAFELFEGLKAYRTPQNTItMFRPDKNMARMNKSAARICLP-TFESEELIKLTGKLIEQDkhlvpqgNGYSLYIRPT 163
Cdd:TIGR01122  20 ALHYGTGVFEGIRAYDTDKGPA-IFRLKEHIQRLYDSAKIYRMEiPYSKEELMEATRETLRKN-------NLRSAYIRPL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323  164 MIGTSKGLGV----GTPSEalLYVITSPVGPYYKT-----GFKAVRLEATDYATRAWPGGVgdkKLGANYAPCILPQLQA 234
Cdd:TIGR01122  92 VFRGDGDLGLnpraGYKPD--VIIAAWPWGAYLGEealekGIDAKVSSWRRNAPNTIPTAA---KAGGNYLNSLLAKSEA 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323  235 AKRGYQQNLWLfGPEKNITEvGTMNVFFVFLNKVtgkkeLVTAPLDGTILEGVTRDSVLTLARdkldpqewdinERYYTI 314
Cdd:TIGR01122 167 RRHGYDEAILL-DVEGYVAE-GSGENIFIVKDGV-----LFTPPVTSSILPGITRDTVITLAK-----------ELGIEV 228

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 768811323  315 TEvaTRAKQGELL---EAFGSGTAAVVSPIKEIgwNNEDIHvpllPGeQCGALTKQVAQWIADIQYGRV-NYGNW 385
Cdd:TIGR01122 229 VE--QPISREELYtadEAFFTGTAAEITPIREV--DGRKIG----NG-RRGPVTKKLQEAFFDLVTGGTeDYWGW 294
D-AAT_like cd01558
D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes ...
 85-344 7.79e-18

D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and D-glutamate in addition to other D-amino acids. The enzyme like other members of this superfamily requires PLP as a cofactor. Members of this subgroup are found in all three forms of life.


Pssm-ID: 238799 [Multi-domain]  Cd Length: 270  Bit Score: 82.65  E-value: 7.79e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323  85 VFHYAFELFEGLKAYRTpqntiTMFRPDKNMARMNKSAARICLPT-FESEELIKLTGKLIEQDKhlvpQGNGYsLYIRPT 163
Cdd:cd01558   20 GFLFGDGVYEVIRVYNG-----KPFALDEHLDRLYRSAKELRIDIpYTREELKELIRELVAKNE----GGEGD-VYIQVT 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323 164 MiGTSK-GLGVGTPSEALLYVITSP----VGPYYKTGFKAVRLEatdyaTRAWpgGVGDKKLGaNYAPCILPQLQAAKRG 238
Cdd:cd01558   90 R-GVGPrGHDFPKCVKPTVVIITQPlplpPAELLEKGVRVITVP-----DIRW--LRCDIKSL-NLLNNVLAKQEAKEAG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323 239 YQQnLWLFGPEKNITEVGTMNVFFVflnkvtGKKELVTAPLDGTILEGVTRDSVLTLARDKldpqEWDINERYYTITEVA 318
Cdd:cd01558  161 ADE-AILLDADGLVTEGSSSNVFIV------KNGVLVTPPLDNGILPGITRATVIELAKEL----GIPVEERPFSLEELY 229

                        250       260
                 ....*....|....*....|....*.
gi 768811323 319 TrAKqgellEAFGSGTAAVVSPIKEI 344
Cdd:cd01558  230 T-AD-----EVFLTSTTAEVMPVVEI 249
PRK08320 PRK08320
branched-chain amino acid aminotransferase; Reviewed
 93-344 1.35e-10

branched-chain amino acid aminotransferase; Reviewed


Pssm-ID: 236238 [Multi-domain]  Cd Length: 288  Bit Score: 61.81  E-value: 1.35e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323  93 FEGLKAYrtpQNTItmFRPDKNMARMNKSAARICL-PTFESEELiklTGKLIEQdkhlVPQGNGYSLYIRPTMigtSKGL 171
Cdd:PRK08320  33 FEGIRAY---NGRV--FRLKEHIDRLYDSAKAIMLeIPLSKEEM---TEIVLET----LRKNNLRDAYIRLVV---SRGV 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323 172 G--------VGTPSealLYVITSPVGPY----YKTGFKAVRLeatdyATRAWPGGVGD---KKLgaNYAPCILPQLQAAK 236
Cdd:PRK08320  98 GdlgldprkCPKPT---VVCIAEPIGLYpgelYEKGLKVITV-----STRRNRPDALSpqvKSL--NYLNNILAKIEANL 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323 237 RGYQQNLwLFGPEKNITEVGTMNVFFVflnkvtGKKELVTAPLDGTILEGVTRDSVLTLARDKldpqEWDINERYYTITE 316
Cdd:PRK08320 168 AGVDEAI-MLNDEGYVAEGTGDNIFIV------KNGKLITPPTYAGALEGITRNAVIEIAKEL----GIPVREELFTLHD 236

                        250       260
                 ....*....|....*....|....*...
gi 768811323 317 VATrAKqgellEAFGSGTAAVVSPIKEI 344
Cdd:PRK08320 237 LYT-AD-----EVFLTGTAAEVIPVVKV 258
PRK07544 PRK07544
branched-chain amino acid aminotransferase; Validated
 87-345 3.50e-10

branched-chain amino acid aminotransferase; Validated


Pssm-ID: 181025  Cd Length: 292  Bit Score: 60.37  E-value: 3.50e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323  87 HYAFELFEGLKAYrtpQNTItmFRPDKNMARMNKSAARIclpTFEseelIKLTGKLIEQDKHLVPQGNGYS-LYIRPTMI 165
Cdd:PRK07544  33 HYASSVFEGERAY---GGKI--FKLREHSERLRRSAELL---DFE----IPYSVAEIDAAKKETLAANGLTdAYVRPVAW 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323 166 GTSKGLGVGTPSEAL-LYVITSPVGPYY--KTGFKAVRLEATDY---ATRAWPggVGDKKLGAnYAPCILPQLQAAKRGY 239
Cdd:PRK07544 101 RGSEMMGVSAQQNKIhLAIAAWEWPSYFdpEAKMKGIRLDIAKWrrpDPETAP--SAAKAAGL-YMICTISKHAAEAKGY 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323 240 QQNLwLFGPEKNITEVGTMNVFFVflnkvtgKKELVTAPLDGTILEGVTRDSVLTLARDKldpqEWDINERYYTITEVAT 319
Cdd:PRK07544 178 ADAL-MLDYRGYVAEATGANIFFV-------KDGVIHTPTPDCFLDGITRQTVIELAKRR----GIEVVERHIMPEELAG 245

                        250       260
                 ....*....|....*....|....*.
gi 768811323 320 rakqgeLLEAFGSGTAAVVSPIKEIG 345
Cdd:PRK07544 246 ------FSECFLTGTAAEVTPVSEIG 265
ADCL_like cd01559
ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent ...
 86-345 7.38e-09

ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most members of this subgroup are likely to function as dimers. The enzyme from E.Coli, the structure of which is available, is a homodimer that is folded into a small and a larger domain. The coenzyme pyridoxal 5; -phosphate resides at the interface of the two domains that is linked by a flexible loop. Members of this subgroup are found in Eukaryotes and bacteria.


Pssm-ID: 238800 [Multi-domain]  Cd Length: 249  Bit Score: 55.78  E-value: 7.38e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323  86 FHYAFELFEGLKAYRTpqntitmfRP---DKNMARMNKSAARICLPTFESEELIKLTGKLIEQDkhlvPQGNGYslyIRP 162
Cdd:cd01559    4 FAYGDGVFETMRALDG--------RLfllDAHLARLERSARRLGIPEPDLPRLRAALESLLAAN----DIDEGR---IRL 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323 163 TMIGTSKGLGVGTPSEA--LLYVITSPVGPyyKTGFKAVRLEATDYATRAWPGGVGDKKLgaNYAPCILPQLQAAKRGYQ 240
Cdd:cd01559   69 ILSRGPGGRGYAPSVCPgpALYVSVIPLPP--AWRQDGVRLITCPVRLGEQPLLAGLKHL--NYLENVLAKREARDRGAD 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323 241 QNLWLfGPEKNITEVGTMNVFFVFLNkvtgkkELVTAPLDGTILEGVTRDSVLTLARDkldpQEWDINERYytitEVATR 320
Cdd:cd01559  145 EALFL-DTDGRVIEGTASNLFFVKDG------ELVTPSLDRGGLAGITRQRVIELAAA----KGYAVDERP----LRLED 209

                        250       260
                 ....*....|....*....|....*
gi 768811323 321 AKQGEllEAFGSGTAAVVSPIKEIG 345
Cdd:cd01559  210 LLAAD--EAFLTNSLLGVAPVTAID 232
PRK12479 PRK12479
branched-chain-amino-acid transaminase;
86-345 1.84e-07

branched-chain-amino-acid transaminase;


Pssm-ID: 183549 [Multi-domain]  Cd Length: 299  Bit Score: 52.26  E-value: 1.84e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323  86 FHYAFELFEGLKAYRTpqntiTMFRPDKNMARMNKSAARICLPtfeseelIKLTGKLIEQDKHLVPQGNGYS-LYIRpTM 164
Cdd:PRK12479  27 FLYGDGVFEGIRSYGG-----NVFCLKEHVKRLYESAKSILLT-------IPLTVDEMEEAVLQTLQKNEYAdAYIR-LI 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323 165 IGTSKG-LGVG--TPSEALLYVITSPVGPY----YKTGFKAVRLEATdyatRAWPGGVGDKKLGANYAPCILPQLQAAKR 237
Cdd:PRK12479  94 VSRGKGdLGLDprSCVKPSVIIIAEQLKLFpqefYDNGLSVVSVASR----RNTPDALDPRIKSMNYLNNVLVKIEAAQA 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323 238 GYQQNLWLfGPEKNITEVGTMNVFFVFLNKVtgkkelVTAPLDGTILEGVTRDSVLTLARDKLDPQEwdinERYYTITEV 317
Cdd:PRK12479 170 GVLEALML-NQQGYVCEGSGDNVFVVKDGKV------LTPPSYLGALEGITRNSVIELCERLSIPCE----ERPFTRHDV 238

                        250       260       270
                 ....*....|....*....|....*....|...
gi 768811323 318 ATRAkqgellEAFGSGTAAVVSPI-----KEIG 345
Cdd:PRK12479 239 YVAD------EVFLTGTAAELIPVvkvdsREIG 265
PRK06680 PRK06680
D-amino acid aminotransferase; Reviewed
 227-345 3.23e-07

D-amino acid aminotransferase; Reviewed


Pssm-ID: 180656 [Multi-domain]  Cd Length: 286  Bit Score: 51.47  E-value: 3.23e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323 227 CILPQL---QAAK-RGYQQnLWLFGpEKNITEVGTMNVFFVflnkvTGKKELVTAPLDGTILEGVTRDSVLTLARdkldP 302
Cdd:PRK06680 152 GLLPNVlakQAAKeAGAQE-AWMVD-DGFVTEGASSNAWIV-----TKDGKLVTRPADNFILPGITRHTLIDLAK----E 220

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 768811323 303 QEWDINERYYTITEvATRAKqgellEAFGSGTAAVVSPIKEIG 345
Cdd:PRK06680 221 LGLEVEERPFTLQE-AYAAR-----EAFITAASSFVFPVVQID 257
PLN02845 PLN02845
Branched-chain-amino-acid aminotransferase-like protein
 177-351 2.88e-05

Branched-chain-amino-acid aminotransferase-like protein


Pssm-ID: 215454 [Multi-domain]  Cd Length: 336  Bit Score: 45.78  E-value: 2.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323 177 SEALLY--VITSPVGPYYKTGFKAVR----LEATDYATrawpggvgdkKLGANYAPCILPQLQAAKRGYQQNLWLFGpEK 250
Cdd:PLN02845 146 SEPAFYavVIEDTYAQDRPEGVKVVTssvpIKPPQFAT----------VKSVNYLPNALSQMEAEERGAFAGIWLDE-EG 214

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323 251 NITEVGTMNVFFvflnkVTGKKELVTAPLDgTILEGVTRDSVLTLARDKLDPQEW-DINERYYTITEvATRAKqgellEA 329
Cdd:PLN02845 215 FVAEGPNMNVAF-----LTNDGELVLPPFD-KILSGCTARRVLELAPRLVSPGDLrGVKQRKISVEE-AKAAD-----EM 282

                        170       180
                 ....*....|....*....|..
gi 768811323 330 FGSGTAAVVSPIkeIGWNNEDI 351
Cdd:PLN02845 283 MLIGSGVPVLPI--VSWDGQPI 302
PRK13356 PRK13356
branched-chain amino acid aminotransferase;
112-344 1.02e-04

branched-chain amino acid aminotransferase;


Pssm-ID: 237362  Cd Length: 286  Bit Score: 43.79  E-value: 1.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323 112 DKNMARMNKSAARICL-PTFESEELIKLTgklIEQDKHLVPQGngySLYIRPTMIGTSKGLGVGTPSEA----LLYVITS 186
Cdd:PRK13356  51 DLHCARVNRSAEALGLkPTVSAEEIEALA---REGLKRFDPDT---ALYIRPMYWAEDGFASGVAPDPEstrfALCLEEA 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323 187 PVGPyyKTGFKAVRleaTDYAtRAWPG-GVGDKKlganyAPCILPQ-----LQAAKRGYQQNLWLfGPEKNITEVGTMNV 260
Cdd:PRK13356 125 PMPE--PTGFSLTL---SPFR-RPTLEmAPTDAK-----AGCLYPNnaralREARSRGFDNALVL-DMLGNVAETATSNV 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768811323 261 FFVflnkvtgKKELVTAPLD-GTILEGVTRDSVLTLARDkldpQEWDINERYYTITEVAtrakqgELLEAFGSGTAAVVS 339
Cdd:PRK13356 193 FMV-------KDGVVFTPVPnGTFLNGITRQRVIALLRE----DGVTVVETTLTYEDFL------EADEVFSTGNYSKVV 255


                 ....*
gi 768811323 340 PIKEI 344
Cdd:PRK13356 256 PVTRF 260
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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