|
Name |
Accession |
Description |
Interval |
E-value |
| GadA |
COG0076 |
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport ... |
5-469 |
4.52e-170 |
|
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport and metabolism]; Glutamate or tyrosine decarboxylase or a related PLP-dependent protein is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis
Pssm-ID: 439846 [Multi-domain] Cd Length: 460 Bit Score: 486.26 E-value: 4.52e-170
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822093507 5 QFRQYGHQLIDLIADYRQTVgERPVMAQvEPGYLKAALPATAPQQGEPFAAILDDVNNLVMPGLSHWQHPDFYGYFPSNG 84
Cdd:COG0076 1 EFRALLHQALDLAADYLAGL-DRPVFGP-SPEELRAALDEPLPEEGLPPEEALAELEDLVLPGSVDWNHPRFLAFVTGGT 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822093507 85 TLSSVLGDFLSTGLGVLGLSWQSSPALSELEETTLDWLRQLLGLSGQWSGVIQDTASTSTLVALISARERATDYALVRGG 164
Cdd:COG0076 79 TPAALAADLLASALNQNMGDWDTSPAATELEREVVRWLADLLGLPEGAGGVFTSGGTEANLLALLAARDRALARRVRAEG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822093507 165 LQAEPKPlIVYVSAHAHSSVDKAALLAGFGRDNIRLIPTDERYALRPEALQAAIEQDLAAGNQPCAVVATTGTTTTTALD 244
Cdd:COG0076 159 LPGAPRP-RIVVSEEAHSSVDKAARLLGLGRDALRKVPVDEDGRMDPDALEAAIDEDRAAGLNPIAVVATAGTTNTGAID 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822093507 245 PLRPVGEIAQANGLWLHVDSAMAGSAMILPECRWMWDGIELADSVVVNAHKWLGVAFDCSIYYVRDPQHLIRVMSTNPSY 324
Cdd:COG0076 238 PLAEIADIAREHGLWLHVDAAYGGFALPSPELRHLLDGIERADSITVDPHKWLYVPYGCGAVLVRDPELLREAFSFHASY 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822093507 325 LQSAVDGEVkNLRDWGIPLGRRFRALKLWFMLRSEGVDALQARLRRDLDNAQWLAGQVEAAAEWEVLAPVQLQTLCIRHR 404
Cdd:COG0076 318 LGPADDGVP-NLGDYTLELSRRFRALKLWATLRALGREGYRELIERCIDLARYLAEGIAALPGFELLAPPELNIVCFRYK 396
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 822093507 405 PAGLEGEalDAHTKGWAERLNASGAAYVTPATLDGRWMVRVSIGALPTERGDVQRLWARLQDVIK 469
Cdd:COG0076 397 PAGLDEE--DALNYALRDRLRARGRAFLSPTKLDGRVVLRLVVLNPRTTEDDVDALLDDLREAAA 459
|
|
| PLN02880 |
PLN02880 |
tyrosine decarboxylase |
1-466 |
1.94e-136 |
|
tyrosine decarboxylase
Pssm-ID: 215475 [Multi-domain] Cd Length: 490 Bit Score: 401.98 E-value: 1.94e-136
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822093507 1 MTPEQFRQYGHQLIDLIADYRQTVGERPVMAQVEPGYLKAALPATAPQQGEPFAAILDDVNNLVMPGLSHWQHPDFYGYF 80
Cdd:PLN02880 10 MDAEQLRECGHRMVDFIADYYKSIENFPVLSQVQPGYLRELLPDSAPNQPETLDQVLDDVQAKILPGVTHWQSPNYFAYY 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822093507 81 PSNGTLSSVLGDFLSTGLGVLGLSWQSSPALSELEETTLDWLRQLLGL------SGQWSGVIQDTASTSTLVALISARER 154
Cdd:PLN02880 90 PSNSSVAGFLGEMLSAGLNIVGFSWITSPAATELEMIVLDWLAKLLNLpeqflsTGNGGGVIQGTASEAVLVVLLAARDR 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822093507 155 atdyALVRGGLQAEPKpLIVYVSAHAHSSVDKAALLAGFGRDNIRLIPTD--ERYALRPEALQAAIEQDLAAGNQPCAVV 232
Cdd:PLN02880 170 ----VLRKVGKNALEK-LVVYASDQTHSALQKACQIAGIHPENCRLLKTDssTNYALAPELLSEAISTDLSSGLIPFFLC 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822093507 233 ATTGTTTTTALDPLRPVGEIAQANGLWLHVDSAMAGSAMILPECRWMWDGIELADSVVVNAHKWLGVAFDCSIYYVRDPQ 312
Cdd:PLN02880 245 ATVGTTSSTAVDPLLELGKIAKSNGMWFHVDAAYAGSACICPEYRHYIDGVEEADSFNMNAHKWFLTNFDCSLLWVKDRN 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822093507 313 HLIRVMSTNPSYLQSAVD--GEVKNLRDWGIPLGRRFRALKLWFMLRSEGVDALQARLRRDLDNAQWLAGQVEAAAEWEV 390
Cdd:PLN02880 325 ALIQSLSTNPEFLKNKASqaNSVVDYKDWQIPLGRRFRSLKLWMVLRLYGVENLQSYIRNHIKLAKEFEQLVAQDSRFEV 404
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 822093507 391 LAPVQLQTLCIRHRPAGLEGEALDAHTKGWAERLNASGAAYVTPATLDGRWMVRVSIGALPTERGDVQRLWARLQD 466
Cdd:PLN02880 405 VTPRIFSLVCFRLVPPKNNEDNGNKLNHDLLDAVNSSGKIFISHTVLSGKYVLRFAVGAPLTEERHVTAAWKVLQD 480
|
|
| Pyridoxal_deC |
pfam00282 |
Pyridoxal-dependent decarboxylase conserved domain; |
35-402 |
8.29e-101 |
|
Pyridoxal-dependent decarboxylase conserved domain;
Pssm-ID: 395219 Cd Length: 373 Bit Score: 306.65 E-value: 8.29e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822093507 35 PGYLKAALPATAPQQGEPFAAILDDVNNLVMPGLSHWQHPDFYGYFPSNGTLSSVLGDFLSTGLGVLGLSWQSSPALSEL 114
Cdd:pfam00282 1 PGYLKPLLPLAAPIIPEPELQIDGDIRRNLMPGVTTWHSPHFHAYMPTGNSYPSLLGDMLTDAINCNGFTWESSPACTEL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822093507 115 EETTLDWLRQLLGLSGQWS-----GVIQDTASTSTLVALISARER------ATDYALVRGGLQAEpkpLIVYVSAHAHSS 183
Cdd:pfam00282 81 ENVVMNWLGEMLGLPAEFLgqeggGVLQPGSSESNLLALLAARTKwikrmkAAGKPADSSGILAK---LVAYTSDQAHSS 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822093507 184 VDKAALLAGFGrdnIRLIPTDERYALRPEALQAAIEQDLAAGNQPCAVVATTGTTTTTALDPLRPVGEIAQANGLWLHVD 263
Cdd:pfam00282 158 IEKAALYGGVK---LREIPSDDNGKMRGMDLEKAIEEDKENGLIPFFVVATLGTTGSGAFDDLQELGDICAKHNLWLHVD 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822093507 264 SAMAGSAMILPECRWMWDGIELADSVVVNAHKWLGVAFDCSIYYVRDPQHLIRVMSTNPSYLQ---SAVDgevknLRDWG 340
Cdd:pfam00282 235 AAYGGSAFICPEFRHWLFGIERADSITFNPHKWMLVLLDCSAVWVKDKEALQQAFQFNPLYLGhtdSAYD-----TGHKQ 309
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 822093507 341 IPLGRRFRALKLWFMLRSEGVDALQARLRRDLDNAQWLAGQVEAAAEWEVLAPVQLQTLCIR 402
Cdd:pfam00282 310 IPLSRRFRILKLWFVIRSLGVEGLQNQIRRHVELAQYLEALIRKDGRFEICAEVGLGLVCFR 371
|
|
| DOPA_deC_like |
cd06450 |
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
76-466 |
1.62e-81 |
|
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and glutamate decarboxylase (GDC). DDC is active as a dimer and catalyzes the decarboxylation of tyrosine. GDC catalyzes the decarboxylation of glutamate and HDC catalyzes the decarboxylation of histidine.
Pssm-ID: 99743 [Multi-domain] Cd Length: 345 Bit Score: 255.98 E-value: 1.62e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822093507 76 FYGYFPSNGTLSSVLGDFLSTGLGVLGLSWQSSPALSELEETTLDWLRQLLGL-SGQWSGVIQDTASTSTLVALISARER 154
Cdd:cd06450 1 FLAGFVTTMDPPALLLEMLTSAKNAIDFTWDESPAATEMEAEVVNWLAKLFGLpSEDADGVFTSGGSESNLLALLAARDR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822093507 155 AtdYALVRGGLQAEPKPLIVYVSAHAHSSVDKAALLAGfgrDNIRLIPTDERYALRPEALQAAIEQDLAAGNQPCAVVAT 234
Cdd:cd06450 81 A--RKRLKAGGGRGIDKLVIVCSDQAHVSVEKAAAYLD---VKVRLVPVDEDGRMDPEALEAAIDEDKAEGLNPIMVVAT 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822093507 235 TGTTTTTALDPLRPVGEIAQANGLWLHVDSAMAGSAMILPECRWMWDGIELADSVVVNAHKWLGVAFDCSIyyvrdpqhl 314
Cdd:cd06450 156 AGTTDTGAIDPLEEIADLAEKYDLWLHVDAAYGGFLLPFPEPRHLDFGIERVDSISVDPHKYGLVPLGCSA--------- 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822093507 315 irVMstnpsylqsavdgevknlrdwgiplgrrFRALKLWFMLRSEGVDALQARLRRDLDNAQWLAGQVEAAAEWEVLAPV 394
Cdd:cd06450 227 --VL----------------------------VRALKLWATLRRFGRDGYGEHIDRIVDLAKYLAELIRADPGFELLGEP 276
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 822093507 395 QLQTLCIRHRPAglegEALDAHTKGWAERLNASGAAYVTPATLDGRWMVRVSIGALPTERGDVQRLWARLQD 466
Cdd:cd06450 277 NLSLVCFRLKPS----VKLDELNYDLSDRLNERGGWHVPATTLGGPNVLRFVVTNPLTTRDDADALLEDIER 344
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| GadA |
COG0076 |
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport ... |
5-469 |
4.52e-170 |
|
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport and metabolism]; Glutamate or tyrosine decarboxylase or a related PLP-dependent protein is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis
Pssm-ID: 439846 [Multi-domain] Cd Length: 460 Bit Score: 486.26 E-value: 4.52e-170
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822093507 5 QFRQYGHQLIDLIADYRQTVgERPVMAQvEPGYLKAALPATAPQQGEPFAAILDDVNNLVMPGLSHWQHPDFYGYFPSNG 84
Cdd:COG0076 1 EFRALLHQALDLAADYLAGL-DRPVFGP-SPEELRAALDEPLPEEGLPPEEALAELEDLVLPGSVDWNHPRFLAFVTGGT 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822093507 85 TLSSVLGDFLSTGLGVLGLSWQSSPALSELEETTLDWLRQLLGLSGQWSGVIQDTASTSTLVALISARERATDYALVRGG 164
Cdd:COG0076 79 TPAALAADLLASALNQNMGDWDTSPAATELEREVVRWLADLLGLPEGAGGVFTSGGTEANLLALLAARDRALARRVRAEG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822093507 165 LQAEPKPlIVYVSAHAHSSVDKAALLAGFGRDNIRLIPTDERYALRPEALQAAIEQDLAAGNQPCAVVATTGTTTTTALD 244
Cdd:COG0076 159 LPGAPRP-RIVVSEEAHSSVDKAARLLGLGRDALRKVPVDEDGRMDPDALEAAIDEDRAAGLNPIAVVATAGTTNTGAID 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822093507 245 PLRPVGEIAQANGLWLHVDSAMAGSAMILPECRWMWDGIELADSVVVNAHKWLGVAFDCSIYYVRDPQHLIRVMSTNPSY 324
Cdd:COG0076 238 PLAEIADIAREHGLWLHVDAAYGGFALPSPELRHLLDGIERADSITVDPHKWLYVPYGCGAVLVRDPELLREAFSFHASY 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822093507 325 LQSAVDGEVkNLRDWGIPLGRRFRALKLWFMLRSEGVDALQARLRRDLDNAQWLAGQVEAAAEWEVLAPVQLQTLCIRHR 404
Cdd:COG0076 318 LGPADDGVP-NLGDYTLELSRRFRALKLWATLRALGREGYRELIERCIDLARYLAEGIAALPGFELLAPPELNIVCFRYK 396
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 822093507 405 PAGLEGEalDAHTKGWAERLNASGAAYVTPATLDGRWMVRVSIGALPTERGDVQRLWARLQDVIK 469
Cdd:COG0076 397 PAGLDEE--DALNYALRDRLRARGRAFLSPTKLDGRVVLRLVVLNPRTTEDDVDALLDDLREAAA 459
|
|
| PLN02880 |
PLN02880 |
tyrosine decarboxylase |
1-466 |
1.94e-136 |
|
tyrosine decarboxylase
Pssm-ID: 215475 [Multi-domain] Cd Length: 490 Bit Score: 401.98 E-value: 1.94e-136
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822093507 1 MTPEQFRQYGHQLIDLIADYRQTVGERPVMAQVEPGYLKAALPATAPQQGEPFAAILDDVNNLVMPGLSHWQHPDFYGYF 80
Cdd:PLN02880 10 MDAEQLRECGHRMVDFIADYYKSIENFPVLSQVQPGYLRELLPDSAPNQPETLDQVLDDVQAKILPGVTHWQSPNYFAYY 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822093507 81 PSNGTLSSVLGDFLSTGLGVLGLSWQSSPALSELEETTLDWLRQLLGL------SGQWSGVIQDTASTSTLVALISARER 154
Cdd:PLN02880 90 PSNSSVAGFLGEMLSAGLNIVGFSWITSPAATELEMIVLDWLAKLLNLpeqflsTGNGGGVIQGTASEAVLVVLLAARDR 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822093507 155 atdyALVRGGLQAEPKpLIVYVSAHAHSSVDKAALLAGFGRDNIRLIPTD--ERYALRPEALQAAIEQDLAAGNQPCAVV 232
Cdd:PLN02880 170 ----VLRKVGKNALEK-LVVYASDQTHSALQKACQIAGIHPENCRLLKTDssTNYALAPELLSEAISTDLSSGLIPFFLC 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822093507 233 ATTGTTTTTALDPLRPVGEIAQANGLWLHVDSAMAGSAMILPECRWMWDGIELADSVVVNAHKWLGVAFDCSIYYVRDPQ 312
Cdd:PLN02880 245 ATVGTTSSTAVDPLLELGKIAKSNGMWFHVDAAYAGSACICPEYRHYIDGVEEADSFNMNAHKWFLTNFDCSLLWVKDRN 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822093507 313 HLIRVMSTNPSYLQSAVD--GEVKNLRDWGIPLGRRFRALKLWFMLRSEGVDALQARLRRDLDNAQWLAGQVEAAAEWEV 390
Cdd:PLN02880 325 ALIQSLSTNPEFLKNKASqaNSVVDYKDWQIPLGRRFRSLKLWMVLRLYGVENLQSYIRNHIKLAKEFEQLVAQDSRFEV 404
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 822093507 391 LAPVQLQTLCIRHRPAGLEGEALDAHTKGWAERLNASGAAYVTPATLDGRWMVRVSIGALPTERGDVQRLWARLQD 466
Cdd:PLN02880 405 VTPRIFSLVCFRLVPPKNNEDNGNKLNHDLLDAVNSSGKIFISHTVLSGKYVLRFAVGAPLTEERHVTAAWKVLQD 480
|
|
| PLN02590 |
PLN02590 |
probable tyrosine decarboxylase |
1-465 |
1.14e-112 |
|
probable tyrosine decarboxylase
Pssm-ID: 178200 [Multi-domain] Cd Length: 539 Bit Score: 342.85 E-value: 1.14e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822093507 1 MTPEQFRQYGHQLIDLIADYRQTVGERP----VMAQVEPGYLKAALPATAPQQGEPFAAILDDVNNLVMPGLSHWQHPDF 76
Cdd:PLN02590 54 MDSELLREQGHIMVDFIADYYKNLQDSPqdfpVLSQVQPGYLRDMLPDSAPERPESLKELLDDVSKKIMPGITHWQSPSY 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822093507 77 YGYFPSNGTLSSVLGDFLSTGLGVLGLSWQSSPALSELEETTLDWLRQLLGL------SGQWSGVIQDTASTSTLVALIS 150
Cdd:PLN02590 134 FAYYASSTSVAGFLGEMLNAGLSVVGFTWLTSPAATELEIIVLDWLAKLLQLpdhflsTGNGGGVIQGTGCEAVLVVVLA 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822093507 151 ARERAtdyaLVRGGLQAEPKpLIVYVSAHAHSSVDKAALLAGFGRDNIRLIPTDE--RYALRPEALQAAIEQDLAAGNQP 228
Cdd:PLN02590 214 ARDRI----LKKVGKTLLPQ-LVVYGSDQTHSSFRKACLIGGIHEENIRLLKTDSstNYGMPPESLEEAISHDLAKGFIP 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822093507 229 CAVVATTGTTTTTALDPLRPVGEIAQANGLWLHVDSAMAGSAMILPECRWMWDGIELADSVVVNAHKWLGVAFDCSIYYV 308
Cdd:PLN02590 289 FFICATVGTTSSAAVDPLVPLGNIAKKYGIWLHVDAAYAGNACICPEYRKFIDGIENADSFNMNAHKWLFANQTCSPLWV 368
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822093507 309 RDPQHLIRVMSTNPSYLQSAVDGE--VKNLRDWGIPLGRRFRALKLWFMLRSEGVDALQARLRRDLDNAQWLAGQVEAAA 386
Cdd:PLN02590 369 KDRYSLIDALKTNPEYLEFKVSKKdtVVNYKDWQISLSRRFRSLKLWMVLRLYGSENLRNFIRDHVNLAKHFEDYVAQDP 448
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 822093507 387 EWEVLAPVQLQTLCIRHRPAGLEGEALDAHTKGWAERLNASGAAYVTPATLDGRWMVRVSIGALPTERGDVQRLWARLQ 465
Cdd:PLN02590 449 SFEVVTTRYFSLVCFRLAPVDGDEDQCNERNRELLAAVNSTGKIFISHTALSGKFVLRFAVGAPLTEEKHVTEAWQIIQ 527
|
|
| Pyridoxal_deC |
pfam00282 |
Pyridoxal-dependent decarboxylase conserved domain; |
35-402 |
8.29e-101 |
|
Pyridoxal-dependent decarboxylase conserved domain;
Pssm-ID: 395219 Cd Length: 373 Bit Score: 306.65 E-value: 8.29e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822093507 35 PGYLKAALPATAPQQGEPFAAILDDVNNLVMPGLSHWQHPDFYGYFPSNGTLSSVLGDFLSTGLGVLGLSWQSSPALSEL 114
Cdd:pfam00282 1 PGYLKPLLPLAAPIIPEPELQIDGDIRRNLMPGVTTWHSPHFHAYMPTGNSYPSLLGDMLTDAINCNGFTWESSPACTEL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822093507 115 EETTLDWLRQLLGLSGQWS-----GVIQDTASTSTLVALISARER------ATDYALVRGGLQAEpkpLIVYVSAHAHSS 183
Cdd:pfam00282 81 ENVVMNWLGEMLGLPAEFLgqeggGVLQPGSSESNLLALLAARTKwikrmkAAGKPADSSGILAK---LVAYTSDQAHSS 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822093507 184 VDKAALLAGFGrdnIRLIPTDERYALRPEALQAAIEQDLAAGNQPCAVVATTGTTTTTALDPLRPVGEIAQANGLWLHVD 263
Cdd:pfam00282 158 IEKAALYGGVK---LREIPSDDNGKMRGMDLEKAIEEDKENGLIPFFVVATLGTTGSGAFDDLQELGDICAKHNLWLHVD 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822093507 264 SAMAGSAMILPECRWMWDGIELADSVVVNAHKWLGVAFDCSIYYVRDPQHLIRVMSTNPSYLQ---SAVDgevknLRDWG 340
Cdd:pfam00282 235 AAYGGSAFICPEFRHWLFGIERADSITFNPHKWMLVLLDCSAVWVKDKEALQQAFQFNPLYLGhtdSAYD-----TGHKQ 309
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 822093507 341 IPLGRRFRALKLWFMLRSEGVDALQARLRRDLDNAQWLAGQVEAAAEWEVLAPVQLQTLCIR 402
Cdd:pfam00282 310 IPLSRRFRILKLWFVIRSLGVEGLQNQIRRHVELAQYLEALIRKDGRFEICAEVGLGLVCFR 371
|
|
| DOPA_deC_like |
cd06450 |
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
76-466 |
1.62e-81 |
|
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and glutamate decarboxylase (GDC). DDC is active as a dimer and catalyzes the decarboxylation of tyrosine. GDC catalyzes the decarboxylation of glutamate and HDC catalyzes the decarboxylation of histidine.
Pssm-ID: 99743 [Multi-domain] Cd Length: 345 Bit Score: 255.98 E-value: 1.62e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822093507 76 FYGYFPSNGTLSSVLGDFLSTGLGVLGLSWQSSPALSELEETTLDWLRQLLGL-SGQWSGVIQDTASTSTLVALISARER 154
Cdd:cd06450 1 FLAGFVTTMDPPALLLEMLTSAKNAIDFTWDESPAATEMEAEVVNWLAKLFGLpSEDADGVFTSGGSESNLLALLAARDR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822093507 155 AtdYALVRGGLQAEPKPLIVYVSAHAHSSVDKAALLAGfgrDNIRLIPTDERYALRPEALQAAIEQDLAAGNQPCAVVAT 234
Cdd:cd06450 81 A--RKRLKAGGGRGIDKLVIVCSDQAHVSVEKAAAYLD---VKVRLVPVDEDGRMDPEALEAAIDEDKAEGLNPIMVVAT 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822093507 235 TGTTTTTALDPLRPVGEIAQANGLWLHVDSAMAGSAMILPECRWMWDGIELADSVVVNAHKWLGVAFDCSIyyvrdpqhl 314
Cdd:cd06450 156 AGTTDTGAIDPLEEIADLAEKYDLWLHVDAAYGGFLLPFPEPRHLDFGIERVDSISVDPHKYGLVPLGCSA--------- 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822093507 315 irVMstnpsylqsavdgevknlrdwgiplgrrFRALKLWFMLRSEGVDALQARLRRDLDNAQWLAGQVEAAAEWEVLAPV 394
Cdd:cd06450 227 --VL----------------------------VRALKLWATLRRFGRDGYGEHIDRIVDLAKYLAELIRADPGFELLGEP 276
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 822093507 395 QLQTLCIRHRPAglegEALDAHTKGWAERLNASGAAYVTPATLDGRWMVRVSIGALPTERGDVQRLWARLQD 466
Cdd:cd06450 277 NLSLVCFRLKPS----VKLDELNYDLSDRLNERGGWHVPATTLGGPNVLRFVVTNPLTTRDDADALLEDIER 344
|
|
| AAT_I |
cd01494 |
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ... |
111-309 |
7.87e-12 |
|
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).
Pssm-ID: 99742 [Multi-domain] Cd Length: 170 Bit Score: 63.56 E-value: 7.87e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822093507 111 LSELEEttldWLRQLLGLsGQWSGVIQDTASTSTLVALisareratdYALVRGGLQaepkpliVYVSAHAHSSV-DKAAL 189
Cdd:cd01494 2 LEELEE----KLARLLQP-GNDKAVFVPSGTGANEAAL---------LALLGPGDE-------VIVDANGHGSRyWVAAE 60
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822093507 190 LAGFgrdNIRLIPTDERYALRpeaLQAAIEQDLAAGNQPCAVVATTGTTTTTALDPLRPVGEIAQANGLWLHVDSAMAGS 269
Cdd:cd01494 61 LAGA---KPVPVPVDDAGYGG---LDVAILEELKAKPNVALIVITPNTTSGGVLVPLKEIRKIAKEYGILLLVDAASAGG 134
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 822093507 270 AMILPECRWMWDGielADSVVVNAHKWLGVAfDCSIYYVR 309
Cdd:cd01494 135 ASPAPGVLIPEGG---ADVVTFSLHKNLGGE-GGGVVIVK 170
|
|
| PRK02769 |
PRK02769 |
histidine decarboxylase; Provisional |
59-385 |
4.60e-10 |
|
histidine decarboxylase; Provisional
Pssm-ID: 235068 [Multi-domain] Cd Length: 380 Bit Score: 61.21 E-value: 4.60e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822093507 59 DVNNLVMPGLSHWQHPDFYGYFPSNGTLS-SVLGDFLSTGLGVLGlSWQSSP--ALS--ELEETTLDWLRQLLGLSGQWS 133
Cdd:PRK02769 7 DQKEIEDFWLYLRHNQYFNVGYPEAADFDySALKRFFSFSINNCG-DPYSKSnyPLNsfDFERDVMNFFAELFKIPFNES 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822093507 134 -GVIQDTASTSTLVALISARERATDyalvrgglqaepkpLIVYVSAHAHSSVDKAALLAGFGRDNIRLIPTDERyalrpe 212
Cdd:PRK02769 86 wGYITNGGTEGNLYGCYLARELFPD--------------GTLYYSKDTHYSVSKIARLLRIKSRVITSLPNGEI------ 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822093507 213 ALQAAIEQDLAAGNQPCAVVATTGTTTTTALDPLRPVGEIAQANGL---WLHVDSAMAGsaMILPecrWMWDGIEL---- 285
Cdd:PRK02769 146 DYDDLISKIKENKNQPPIIFANIGTTMTGAIDNIKEIQEILKKIGIddyYIHADAALSG--MILP---FVNNPPPFsfad 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822093507 286 -ADSVVVNAHKWLGVAFDCSIYYVRdpQHLIRVMSTNPSYLQSavdgevknlRDWGIpLGRR--FRALKLWFMLRSEGVD 362
Cdd:PRK02769 221 gIDSIAISGHKFIGSPMPCGIVLAK--KKYVERISVDVDYIGS---------RDQTI-SGSRngHTALLLWAAIRSLGSK 288
|
330 340
....*....|....*....|...
gi 822093507 363 ALQARLRRDLDNAQWLAGQVEAA 385
Cdd:PRK02769 289 GLRQRVQHCLDMAQYAVDRLQAN 311
|
|
| PLN03032 |
PLN03032 |
serine decarboxylase; Provisional |
113-385 |
1.51e-09 |
|
serine decarboxylase; Provisional
Pssm-ID: 166673 [Multi-domain] Cd Length: 374 Bit Score: 59.45 E-value: 1.51e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822093507 113 ELEETTLDWLRQLLGL-SGQWSGVIQDTASTSTLVALISARERATDYalvrgglqaepkplIVYVSAHAHSSVDKAALLA 191
Cdd:PLN03032 66 QFEVGVLDWFARLWELeKDEYWGYITTCGTEGNLHGILVGREVFPDG--------------ILYASRESHYSVFKAARMY 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822093507 192 gfgRDNIRLIPTDERYALRPEALQAAIEQDlaaGNQPCAVVATTGTTTTTALDPLRPVGEIAQANG-----LWLHVDSAM 266
Cdd:PLN03032 132 ---RMEAVKVPTLPSGEIDYDDLERALAKN---RDKPAILNVNIGTTVKGAVDDLDRILRILKELGytedrFYIHCDGAL 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822093507 267 AGsaMILPECRW--MWDGIELADSVVVNAHKWLGVAFDCSIYYVRDpQHlIRVMSTNPSYLQSaVDGEVKNLRDWGIPLg 344
Cdd:PLN03032 206 FG--LMMPFVSRapEVTFRKPIGSVSVSGHKFLGCPMPCGVALTRK-KH-VKALSQNVEYLNS-RDATIMGSRNGHAPL- 279
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 822093507 345 rrfralKLWFMLRSEGVDALQARLRRDLDNAQWLAGQVEAA 385
Cdd:PLN03032 280 ------YLWYTLRRKGYRGIKRDVQHCMRNAHYLKDRLTEA 314
|
|
| PLN02263 |
PLN02263 |
serine decarboxylase |
25-385 |
4.85e-07 |
|
serine decarboxylase
Pssm-ID: 177904 [Multi-domain] Cd Length: 470 Bit Score: 52.13 E-value: 4.85e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822093507 25 GERPV-MAQVEPGYLKAALPATAPQQGEPFAAILDdvnnlvMPGLSHWQHpdfygyFPSNGtlssvLGD-FLSTGLGVlg 102
Cdd:PLN02263 69 GDKEAyMASVLARYRKTLVERTKHHLGYPYNLDFD------YGALGQLQH------FSINN-----LGDpFIESNYGV-- 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822093507 103 lswQSSPalseLEETTLDWLRQLLGLS-GQWSGVIQDTASTSTLVALISARERATDYalvrgglqaepkplIVYVSAHAH 181
Cdd:PLN02263 130 ---HSRQ----FEVGVLDWFARLWEIEkNEYWGYITNCGTEGNLHGILVGREVFPDG--------------ILYASRESH 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822093507 182 SSVDKAALLAgfgRDNIRLIPTDERYALRPEALQAAIeqdLAAGNQPCAVVATTGTTTTTALDPLRPVGEIAQANG---- 257
Cdd:PLN02263 189 YSVFKAARMY---RMECVKVDTLVSGEIDCADFKAKL---LANKDKPAIINVNIGTTVKGAVDDLDLVIKTLEECGfsqd 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822093507 258 -LWLHVDSAMAGSAMILPECRWMWDGIELADSVVVNAHKWLGVAFDCSIYYVRdPQHlIRVMSTNPSYLQSavdgevknl 336
Cdd:PLN02263 263 rFYIHCDGALFGLMMPFVKRAPKVTFKKPIGSVSVSGHKFVGCPMPCGVQITR-MEH-INVLSSNVEYLAS--------- 331
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 822093507 337 RDWGIPLGRRFRA-LKLWFMLRSEGVDALQARLRRDLDNAQWLAGQVEAA 385
Cdd:PLN02263 332 RDATIMGSRNGHApIFLWYTLNRKGYRGFQKEVQKCLRNAHYLKDRLREA 381
|
|
| Beta_elim_lyase |
pfam01212 |
Beta-eliminating lyase; |
174-384 |
1.70e-03 |
|
Beta-eliminating lyase;
Pssm-ID: 426128 [Multi-domain] Cd Length: 288 Bit Score: 40.28 E-value: 1.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822093507 174 VYVSAHAHSSVDKAALLAGFGRDNIRLIPTDERYALRPEALQAAIEQDLAAGNQPCAVVATTGTTTTTA-----LDPLRP 248
Cdd:pfam01212 74 VICGEPAHIHFDETGGHAELGGVQPRPLDGDEAGNMDLEDLEAAIREVGADIFPPTGLISLENTHNSAGgqvvsLENLRE 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822093507 249 VGEIAQANGLWLHVDSA-----MAGSAMILPECrwmwdgIELADSVVVNAHKWLGV---AFDCsiyyvrdpqhlirvmsT 320
Cdd:pfam01212 154 IAALAREHGIPVHLDGArfanaAVALGVIVKEI------TSYADSVTMCLSKGLGApvgSVLA----------------G 211
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 822093507 321 NPSYLQSAVdGEVK----NLRDWGIPLGRRFRALKLWFmlrsegvdalqARLRRDLDNAQWLAGQVEA 384
Cdd:pfam01212 212 SDDFIAKAI-RQRKylggGLRQAGVLAAAGLRALEEGV-----------ARLARDHATARRLAEGLEL 267
|
|
| TA_like |
cd06502 |
Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP) ... |
174-300 |
3.27e-03 |
|
Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a secondary glycine biosynthetic pathway.
Pssm-ID: 99748 [Multi-domain] Cd Length: 338 Bit Score: 39.62 E-value: 3.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822093507 174 VYVSAHAHSSVDKAALLAGFGRDNIRLIPTdERYALRPEALQAAIEQDLAAGNQPCAVVA---TTGTTTTTALDPLRPVG 250
Cdd:cd06502 74 VICHETAHIYTDEAGAPEFLSGVKLLPVPG-ENGKLTPEDLEAAIRPRDDIHFPPPSLVSlenTTEGGTVYPLDELKAIS 152
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 822093507 251 EIAQANGLWLHVDSAM---AGSAMILPECRWMwdgiELADSVVVNAHKWLGVA 300
Cdd:cd06502 153 ALAKENGLPLHLDGARlanAAAALGVALKTYK----SGVDSVSFCLSKGGGAP 201
|
|
| |
