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Conserved domains on  [gi|915983416|gb|AKY03014|]
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N-acetylglucosaminyltransferase [Mycobacterium phage Dante]

Protein Classification

glycosyltransferase family 25 protein( domain architecture ID 3353)

glycosyltransferase family 25 protein may be involved in lipopolysaccharide (LPS) biosynthesis, facilitating the transfer of one of a variety of sugars onto a growing LPS chain

CAZY:  GT25
Gene Ontology:  GO:1901271
PubMed:  9334165

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG3306 super family cl47316
Glycosyltransferase involved in LPS biosynthesis, GR25 family [Cell wall/membrane/envelope ...
 33-171 1.15e-10

Glycosyltransferase involved in LPS biosynthesis, GR25 family [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG3306:

Pssm-ID: 442535 [Multi-domain]  Cd Length: 238  Bit Score: 58.86  E-value: 1.15e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 915983416  33 NGTLGCEANHRKVWQHLTRHNTDWLVVLEDDAIPCNNFRDQLDAALAVAPSP-VVSLYLGRERPREYQQRIAKAADTTAH 111
Cdd:COG3306   63 PGEIGCFLSHRKAWQKIVESGLPYALILEDDVILSPDFAEVLEALAWLPADWdIVKLETSKRKVFLGRRKIKKLGGYRLV 142

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 915983416 112 wLTCRRLLHAVGIAIHADLVPHMLNNLHN-GKPIDEAISAWARHQShTIAYTWPSLIDHAD 171
Cdd:COG3306  143 -RPYSPPLGTAGYLISRKAAKKLLALLEPiDRPVDDFLFRFWLHGL-RVYQVRPALVIQDS 201
 
Name Accession Description Interval E-value
COG3306 COG3306
Glycosyltransferase involved in LPS biosynthesis, GR25 family [Cell wall/membrane/envelope ...
 33-171 1.15e-10

Glycosyltransferase involved in LPS biosynthesis, GR25 family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442535 [Multi-domain]  Cd Length: 238  Bit Score: 58.86  E-value: 1.15e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 915983416  33 NGTLGCEANHRKVWQHLTRHNTDWLVVLEDDAIPCNNFRDQLDAALAVAPSP-VVSLYLGRERPREYQQRIAKAADTTAH 111
Cdd:COG3306   63 PGEIGCFLSHRKAWQKIVESGLPYALILEDDVILSPDFAEVLEALAWLPADWdIVKLETSKRKVFLGRRKIKKLGGYRLV 142

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 915983416 112 wLTCRRLLHAVGIAIHADLVPHMLNNLHN-GKPIDEAISAWARHQShTIAYTWPSLIDHAD 171
Cdd:COG3306  143 -RPYSPPLGTAGYLISRKAAKKLLALLEPiDRPVDDFLFRFWLHGL-RVYQVRPALVIQDS 201
Glyco_transf_25 pfam01755
Glycosyltransferase family 25 (LPS biosynthesis protein); Members of this family belong to ...
 33-78 3.38e-05

Glycosyltransferase family 25 (LPS biosynthesis protein); Members of this family belong to Glycosyltransferase family 25 This is a family of glycosyltransferases involved in lipopolysaccharide (LPS) biosynthesis. These enzymes catalyze the transfer of various sugars onto the growing LPS chain during its biosynthesis.


Pssm-ID: 366794  Cd Length: 200  Bit Score: 42.81  E-value: 3.38e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 915983416   33 NGTLGCEANHRKVWQHLTRHNTDWLVVLEDDAIPCNNFRDQLDAAL 78
Cdd:pfam01755  65 LGEIGCFLSHYSLWQKCVELNLEYIIILEDDVILSENFKAILQFLL 110
Glyco_transf_25 cd06532
Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of ...
 34-65 6.86e-05

Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of Neisseria gonorrhoeae and Lic2A of Haemophilus influenzae. M. catarrhalis Lgt2 catalyzes the addition of galactose (Gal) to the growing chain of LOS on the cell surface. N. gonorrhoeae LgtB and LgtE link Gal-beta(1,4) to GlcNAc (N-acetylglucosamine) and Glc (glucose), respectively. The genes encoding LgtB and LgtE are two genes of a five gene locus involved in the synthesis of gonococcal LOS. LgtE is believed to perform the first step in LOS biosynthesis.


Pssm-ID: 133474  Cd Length: 128  Bit Score: 41.05  E-value: 6.86e-05
                         10        20        30
                 ....*....|....*....|....*....|..
gi 915983416  34 GTLGCEANHRKVWQHLTRHNTDWLVVLEDDAI 65
Cdd:cd06532   63 GEIGCFLSHYKLWQKIVESNLEYALILEDDAI 94
 
Name Accession Description Interval E-value
COG3306 COG3306
Glycosyltransferase involved in LPS biosynthesis, GR25 family [Cell wall/membrane/envelope ...
 33-171 1.15e-10

Glycosyltransferase involved in LPS biosynthesis, GR25 family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442535 [Multi-domain]  Cd Length: 238  Bit Score: 58.86  E-value: 1.15e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 915983416  33 NGTLGCEANHRKVWQHLTRHNTDWLVVLEDDAIPCNNFRDQLDAALAVAPSP-VVSLYLGRERPREYQQRIAKAADTTAH 111
Cdd:COG3306   63 PGEIGCFLSHRKAWQKIVESGLPYALILEDDVILSPDFAEVLEALAWLPADWdIVKLETSKRKVFLGRRKIKKLGGYRLV 142

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 915983416 112 wLTCRRLLHAVGIAIHADLVPHMLNNLHN-GKPIDEAISAWARHQShTIAYTWPSLIDHAD 171
Cdd:COG3306  143 -RPYSPPLGTAGYLISRKAAKKLLALLEPiDRPVDDFLFRFWLHGL-RVYQVRPALVIQDS 201
Glyco_transf_25 pfam01755
Glycosyltransferase family 25 (LPS biosynthesis protein); Members of this family belong to ...
 33-78 3.38e-05

Glycosyltransferase family 25 (LPS biosynthesis protein); Members of this family belong to Glycosyltransferase family 25 This is a family of glycosyltransferases involved in lipopolysaccharide (LPS) biosynthesis. These enzymes catalyze the transfer of various sugars onto the growing LPS chain during its biosynthesis.


Pssm-ID: 366794  Cd Length: 200  Bit Score: 42.81  E-value: 3.38e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 915983416   33 NGTLGCEANHRKVWQHLTRHNTDWLVVLEDDAIPCNNFRDQLDAAL 78
Cdd:pfam01755  65 LGEIGCFLSHYSLWQKCVELNLEYIIILEDDVILSENFKAILQFLL 110
Glyco_transf_25 cd06532
Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of ...
 34-65 6.86e-05

Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of Neisseria gonorrhoeae and Lic2A of Haemophilus influenzae. M. catarrhalis Lgt2 catalyzes the addition of galactose (Gal) to the growing chain of LOS on the cell surface. N. gonorrhoeae LgtB and LgtE link Gal-beta(1,4) to GlcNAc (N-acetylglucosamine) and Glc (glucose), respectively. The genes encoding LgtB and LgtE are two genes of a five gene locus involved in the synthesis of gonococcal LOS. LgtE is believed to perform the first step in LOS biosynthesis.


Pssm-ID: 133474  Cd Length: 128  Bit Score: 41.05  E-value: 6.86e-05
                         10        20        30
                 ....*....|....*....|....*....|..
gi 915983416  34 GTLGCEANHRKVWQHLTRHNTDWLVVLEDDAI 65
Cdd:cd06532   63 GEIGCFLSHYKLWQKIVESNLEYALILEDDAI 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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