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Conserved domains on  [gi|960498878|gb|ALR85561|]
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NADH dehydrogenase subunit I, partial (mitochondrion) [Leatettix cf. emota 58_Lea_62]

Protein Classification

complex I subunit 1 family protein( domain architecture ID 103)

complex I subunit 1 family protein similar to NADH dehydrogenase subunit 1, which is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that functions in the transfer of electrons from NADH to the respiratory chain

EC:  7.1.1.-
Gene Ontology:  GO:0016655|GO:0016020
PubMed:  23417064|24059520
SCOP:  4005664

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK06076 super family cl00469
NADH-quinone oxidoreductase subunit NuoH;
6-104 3.41e-41

NADH-quinone oxidoreductase subunit NuoH;


The actual alignment was detected with superfamily member MTH00193:

Pssm-ID: 469782  Cd Length: 306  Bit Score: 137.21  E-value: 3.41e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 960498878   6 MFMFIINFILLVICVLISVAFLTLLERKVLGFIQIRKGPNKVGVMGVPQPFSDAIKLICSEQPIPILSNYLFYYFSPVFS 85
Cdd:MTH00193   1 LMMMLINFLLLIICVLVSVAFLTLLERKVLGYIQIRKGPNKVGFMGILQPFSDAIKLFTKEQTYPLMSNYLLYYFSPVFS 80

                         90
                 ....*....|....*....
gi 960498878  86 LMISLFIWVIFPYLTYLCS 104
Cdd:MTH00193  81 LFLSLLIWLIYPYLFNLIS 99
 
Name Accession Description Interval E-value
ND1 MTH00193
NADH dehydrogenase subunit 1; Provisional
 6-104 3.41e-41

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 177241  Cd Length: 306  Bit Score: 137.21  E-value: 3.41e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 960498878   6 MFMFIINFILLVICVLISVAFLTLLERKVLGFIQIRKGPNKVGVMGVPQPFSDAIKLICSEQPIPILSNYLFYYFSPVFS 85
Cdd:MTH00193   1 LMMMLINFLLLIICVLVSVAFLTLLERKVLGYIQIRKGPNKVGFMGILQPFSDAIKLFTKEQTYPLMSNYLLYYFSPVFS 80

                         90
                 ....*....|....*....
gi 960498878  86 LMISLFIWVIFPYLTYLCS 104
Cdd:MTH00193  81 LFLSLLIWLIYPYLFNLIS 99
NADHdh pfam00146
NADH dehydrogenase;
14-98 6.36e-19

NADH dehydrogenase;


Pssm-ID: 459690  Cd Length: 302  Bit Score: 78.67  E-value: 6.36e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 960498878   14 ILLVICVLISVAFLTLLERKVLGFIQIRKGPNKVGVMGVPQPFSDAIKLICSEQPIPILSNYLFYYFSPVFSLMISLFIW 93
Cdd:pfam00146   3 LLLLVPLLLAVAFLTWAERKVLARMQRRIGPNRVGPFGLLQPFADALKLLFKEDIIPAGADKFLFLLAPIIAFIPALLAF 82


                  ....*
gi 960498878   94 VIFPY 98
Cdd:pfam00146  83 AVIPF 87
NuoH COG1005
NADH:ubiquinone oxidoreductase subunit 1 (chain H) [Energy production and conversion]; NADH: ...
 5-98 1.41e-18

NADH:ubiquinone oxidoreductase subunit 1 (chain H) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 1 (chain H) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440629  Cd Length: 329  Bit Score: 78.25  E-value: 1.41e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 960498878   5 DMFMFIINFILLVICVLISVAFLTLLERKVLGFIQIRKGPNKVGVMGVPQPFSDAIKLICSEQPIPILSNYLFYYFSPVF 84
Cdd:COG1005    7 PLLITLIKALVILVFLLLLAAYLTWAERKVLARMQDRIGPNRVGPFGLLQPLADGLKLLFKEDIIPAGADKFLFLLAPIL 86

                         90
                 ....*....|....
gi 960498878  85 SLMISLFIWVIFPY 98
Cdd:COG1005   87 AFIPALLAFAVIPF 100
 
Name Accession Description Interval E-value
ND1 MTH00193
NADH dehydrogenase subunit 1; Provisional
 6-104 3.41e-41

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 177241  Cd Length: 306  Bit Score: 137.21  E-value: 3.41e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 960498878   6 MFMFIINFILLVICVLISVAFLTLLERKVLGFIQIRKGPNKVGVMGVPQPFSDAIKLICSEQPIPILSNYLFYYFSPVFS 85
Cdd:MTH00193   1 LMMMLINFLLLIICVLVSVAFLTLLERKVLGYIQIRKGPNKVGFMGILQPFSDAIKLFTKEQTYPLMSNYLLYYFSPVFS 80

                         90
                 ....*....|....*....
gi 960498878  86 LMISLFIWVIFPYLTYLCS 104
Cdd:MTH00193  81 LFLSLLIWLIYPYLFNLIS 99
ND1 MTH00225
NADH dehydrogenase subunit 1; Provisional
 8-102 7.33e-33

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 214465  Cd Length: 305  Bit Score: 115.52  E-value: 7.33e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 960498878   8 MFIINFILLVICVLISVAFLTLLERKVLGFIQIRKGPNKVGVMGVPQPFSDAIKLICSEQPIPILSNYLFYYFSPVFSLM 87
Cdd:MTH00225   2 SFLLKFLIMLICLLLSVAFYTLLERKVLGYIQLRKGPNKVGLMGLPQPFADALKLFTKEQTKPQLSNKLPYYIAPILSLI 81

                         90
                 ....*....|....*
gi 960498878  88 ISLFIWVIFPYLTYL 102
Cdd:MTH00225  82 LSLILWSLYPSMFSI 96
ND1 MTH00143
NADH dehydrogenase subunit 1; Provisional
 7-99 1.13e-28

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 177201  Cd Length: 307  Bit Score: 104.95  E-value: 1.13e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 960498878   7 FMFIINFILLVICVLISVAFLTLLERKVLGFIQIRKGPNKVGVMGVPQPFSDAIKLICSEQPIPILSNYLFYYFSPVFSL 86
Cdd:MTH00143   1 LVSLLSSVFTYLCVLLAVAFFTLLERKGLGYFQIRKGPNKVGLMGLPQPLADAVKLFTKEFVKPTMSNKFPFFLAPCLSL 80

                         90
                 ....*....|...
gi 960498878  87 MISLFIWVIFPYL 99
Cdd:MTH00143  81 ILALLLWQLYPSY 93
ND1 MTH00218
NADH dehydrogenase subunit 1; Provisional
 6-97 1.92e-24

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 214463  Cd Length: 311  Bit Score: 93.82  E-value: 1.92e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 960498878   6 MFMFIINFILLVICVLISVAFLTLLERKVLGFIQIRKGPNKVGVMGVPQPFSDAIKLICSEQPIPILSNYLFYYFSPVFS 85
Cdd:MTH00218   1 MLLSLINLLLYILPVLLAVAFLTLLERKVLGYMQLRKGPNVVGPYGLLQPIADGVKLFIKEPIRPSTSSPFLFLLAPILA 80

                         90
                 ....*....|..
gi 960498878  86 LMISLFIWVIFP 97
Cdd:MTH00218  81 LTLALLLWMPLP 92
ND1 MTH00195
NADH dehydrogenase subunit 1; Provisional
 6-99 5.53e-24

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 214452  Cd Length: 307  Bit Score: 92.50  E-value: 5.53e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 960498878   6 MFMFIINFILLVICVLISVAFLTLLERKVLGFIQIRKGPNKVGVMGVPQPFSDAIKLICSEQPIPILSNYLFYYFSPVFS 85
Cdd:MTH00195   1 WMISVIHFLIQIVPVLLAVAFFTLLERKILGYIQLRKGPNKVGPYGLLQPIADAVKLFIKEPVKPSTSSLWLFFFAPVLA 80

                         90
                 ....*....|....
gi 960498878  86 LMISLFIWVIFPYL 99
Cdd:MTH00195  81 LALALILWVPIPSP 94
ND1 MTH00104
NADH dehydrogenase subunit 1; Provisional
 8-97 5.79e-24

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 177166  Cd Length: 318  Bit Score: 92.38  E-value: 5.79e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 960498878   8 MFIINFILLVICVLISVAFLTLLERKVLGFIQIRKGPNKVGVMGVPQPFSDAIKLICSEQPIPILSNYLFYYFSPVFSLM 87
Cdd:MTH00104   1 MFMINILLLIIPILLAVAFLTLVERKVLGYMQLRKGPNIVGPYGLLQPFADAMKLFTKEPLRPLTSSTTMFIIAPILALT 80

                         90
                 ....*....|
gi 960498878  88 ISLFIWVIFP 97
Cdd:MTH00104  81 LALTMWIPLP 90
ND1 MTH00111
NADH dehydrogenase subunit 1; Provisional
 6-97 1.10e-23

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 214422  Cd Length: 323  Bit Score: 91.88  E-value: 1.10e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 960498878   6 MFMFIINFILLVICVLISVAFLTLLERKVLGFIQIRKGPNKVGVMGVPQPFSDAIKLICSEQPIPILSNYLFYYFSPVFS 85
Cdd:MTH00111   4 LLLNLINPLLYIIPILIAVAFLTLLERKILGYMQLRKGPNIVGPFGLLQPIADGVKLFIKEPIRPSTSSPILFTLTPILA 83

                         90
                 ....*....|..
gi 960498878  86 LMISLFIWVIFP 97
Cdd:MTH00111  84 LLLALTIWTPLP 95
ND1 MTH00010
NADH dehydrogenase subunit 1; Validated
 9-98 1.26e-23

NADH dehydrogenase subunit 1; Validated


Pssm-ID: 164586  Cd Length: 311  Bit Score: 91.77  E-value: 1.26e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 960498878   9 FIINFILLVICVLISVAFLTLLERKVLGFIQIRKGPNKVGVMGVPQPFSDAIKLICSEQPIPILSNYLFYYFSPVFSLMI 88
Cdd:MTH00010   5 FFISILLSYVMALLAMAFYTLLERKALGYFQLRKGPNKVGLAGIPQPFADAIKLFTKEQTKPSPANITPFLGAPMMSLIL 84

                         90
                 ....*....|
gi 960498878  89 SLFIWVIFPY 98
Cdd:MTH00010  85 ALLLWSLYPH 94
ND1 MTH00216
NADH dehydrogenase subunit 1; Provisional
 2-98 1.99e-23

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 164761  Cd Length: 327  Bit Score: 91.33  E-value: 1.99e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 960498878   2 MLYDMFMFIINFILLVICVLISVAFLTLLERKVLGFIQIRKGPNKVGVMGVPQPFSDAIKLICSEQPIPILSNYLFYYFS 81
Cdd:MTH00216   1 MMVFIIFYLIKILIIIVPLLIAVAYLTLAERKVLGYMQARKGPNVVGVYGLLQPFADGVKLFTKEMVIPHHANLFVYIVA 80

                         90
                 ....*....|....*..
gi 960498878  82 PVFSLMISLFIWVIFPY 98
Cdd:MTH00216  81 PVLSFTLALIVWGVIPY 97
ND1 MTH00071
NADH dehydrogenase subunit 1; Provisional
 6-97 6.29e-23

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 214418  Cd Length: 322  Bit Score: 89.68  E-value: 6.29e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 960498878   6 MFMFIINFILLVICVLISVAFLTLLERKVLGFIQIRKGPNKVGVMGVPQPFSDAIKLICSEQPIPILSNYLFYYFSPVFS 85
Cdd:MTH00071   4 LISLIINPLLYIIPVLLAVAFLTLVERKVLGYMQLRKGPNIVGPMGLLQPIADGLKLFIKEPIRPSTSSQILFILMPTMA 83

                         90
                 ....*....|..
gi 960498878  86 LMISLFIWVIFP 97
Cdd:MTH00071  84 LTLALIIWTPLP 95
ND1 MTH00040
NADH dehydrogenase subunit 1; Validated
 7-97 1.17e-22

NADH dehydrogenase subunit 1; Validated


Pssm-ID: 214409  Cd Length: 323  Bit Score: 89.26  E-value: 1.17e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 960498878   7 FMFIINFILLVICVLISVAFLTLLERKVLGFIQIRKGPNKVGVMGVPQPFSDAIKLICSEQPIPILSNYLFYYFSPVFSL 86
Cdd:MTH00040   4 ILFLINLLSFIVPVLLAVAFLTLVERKVLGYMQFRKGPNVVGPYGLLQPFADGLKLFIKETLKPSNASPYLFFFSPVLFL 83

                         90
                 ....*....|.
gi 960498878  87 MISLFIWVIFP 97
Cdd:MTH00040  84 FLALLLWSLIP 94
ND1 MTH00134
NADH dehydrogenase subunit 1; Provisional
 2-97 4.25e-22

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 177192  Cd Length: 324  Bit Score: 87.74  E-value: 4.25e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 960498878   2 MLYDMFMFIINFILLVICVLISVAFLTLLERKVLGFIQIRKGPNKVGVMGVPQPFSDAIKLICSEQPIPILSNYLFYYFS 81
Cdd:MTH00134   1 MLSTLITHIINPLAYIVPVLLAVAFLTLLERKVLGYMQLRKGPNIVGPYGLLQPIADGVKLFIKEPVRPSTSSPFLFLAT 80

                         90
                 ....*....|....*.
gi 960498878  82 PVFSLMISLFIWVIFP 97
Cdd:MTH00134  81 PMLALTLALTLWAPMP 96
ND1 MTH00054
NADH dehydrogenase subunit 1; Provisional
 6-98 2.31e-21

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 177127  Cd Length: 324  Bit Score: 85.55  E-value: 2.31e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 960498878   6 MFMFIINFILLVICVLISVAFLTLLERKVLGFIQIRKGPNKVGVMGVPQPFSDAIKLICSEQPIPILSNYLFYYFSPVFS 85
Cdd:MTH00054   1 MGIIIIKILAILVPLLISIAYLTLAERKVLGYIQCRKGPNVVGVYGLLQPLADGLKLFTKEIIIPNHANIFIYIMAPILS 80

                         90
                 ....*....|...
gi 960498878  86 LMISLFIWVIFPY 98
Cdd:MTH00054  81 LTLAFIAWGVIPY 93
NADHdh pfam00146
NADH dehydrogenase;
14-98 6.36e-19

NADH dehydrogenase;


Pssm-ID: 459690  Cd Length: 302  Bit Score: 78.67  E-value: 6.36e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 960498878   14 ILLVICVLISVAFLTLLERKVLGFIQIRKGPNKVGVMGVPQPFSDAIKLICSEQPIPILSNYLFYYFSPVFSLMISLFIW 93
Cdd:pfam00146   3 LLLLVPLLLAVAFLTWAERKVLARMQRRIGPNRVGPFGLLQPFADALKLLFKEDIIPAGADKFLFLLAPIIAFIPALLAF 82


                  ....*
gi 960498878   94 VIFPY 98
Cdd:pfam00146  83 AVIPF 87
NuoH COG1005
NADH:ubiquinone oxidoreductase subunit 1 (chain H) [Energy production and conversion]; NADH: ...
 5-98 1.41e-18

NADH:ubiquinone oxidoreductase subunit 1 (chain H) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 1 (chain H) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440629  Cd Length: 329  Bit Score: 78.25  E-value: 1.41e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 960498878   5 DMFMFIINFILLVICVLISVAFLTLLERKVLGFIQIRKGPNKVGVMGVPQPFSDAIKLICSEQPIPILSNYLFYYFSPVF 84
Cdd:COG1005    7 PLLITLIKALVILVFLLLLAAYLTWAERKVLARMQDRIGPNRVGPFGLLQPLADGLKLLFKEDIIPAGADKFLFLLAPIL 86

                         90
                 ....*....|....
gi 960498878  85 SLMISLFIWVIFPY 98
Cdd:COG1005   87 AFIPALLAFAVIPF 100
PRK06076 PRK06076
NADH-quinone oxidoreductase subunit NuoH;
8-98 2.21e-16

NADH-quinone oxidoreductase subunit NuoH;


Pssm-ID: 235692  Cd Length: 322  Bit Score: 72.15  E-value: 2.21e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 960498878   8 MFIINFILLVICVLISVAFLTLLERKVLGFIQIRKGPNKVGVMGVPQPFSDAIKLICSEQPIPILSNYLFYYFSPVFSLM 87
Cdd:PRK06076  11 LILLKAVVILVVVLLCVAFLIWFERKVLARMQLRYGPNRVGPFGLLQLVADGIKLLFKEDIIPAGADKVLFLLAPVIAFI 90

                         90
                 ....*....|.
gi 960498878  88 ISLFIWVIFPY 98
Cdd:PRK06076  91 PAFLAWAVIPF 101
ND1 MTH00090
NADH dehydrogenase subunit 1; Provisional
 12-99 4.13e-16

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 177153  Cd Length: 284  Bit Score: 71.08  E-value: 4.13e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 960498878  12 NFILLVICVLISVAFLTLLERKVLGFIQIRKGPNKVGVMGVPQPFSDAIKLICSEQPIPILSNYLFYYFSPVFSLMISLF 91
Cdd:MTH00090   1 MLLLMMIFILQAIAFITLYERHLLGSSQNRLGPNKVSFMGVLQALLDGVKLLKKEQMLPLNSSDLSFLLVPGVSFVVMYL 80


                 ....*...
gi 960498878  92 IWVIFPYL 99
Cdd:MTH00090  81 EWFVLPYF 88
ND1 MTH00029
NADH dehydrogenase subunit 1; Provisional
 1-95 9.52e-16

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 177108  Cd Length: 343  Bit Score: 70.82  E-value: 9.52e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 960498878   1 MMLYDMFMFIINFILLVICVLISVAFLTLLERKVLGFIQIRKGPNKVGVMGVPQPFSDAIKLICSEQPIPILSNYLFYYF 80
Cdd:MTH00029   1 MTIYSYITVTIKLLIIFVPLLLSVAYLTLAERKVLGLMQNRKGPAIVGPWGLVQPIADGVKLLTKELIIPSQANKFLYYI 80

                         90
                 ....*....|....*
gi 960498878  81 SPVFSLMISLFIWVI 95
Cdd:MTH00029  81 APIISFTLAILAWAI 95
ND1 MTH00058
NADH dehydrogenase subunit 1; Provisional
 6-64 1.85e-11

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 177130  Cd Length: 293  Bit Score: 58.40  E-value: 1.85e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 960498878   6 MFMFIINFILLVICVLIsVAFLTLLERKVLGFIQIRKGPNKVGVMGVPQPFSDAIKLIC 64
Cdd:MTH00058   1 IFGLVSGLEGLLIILLL-VAFFILGERKILGYIQLRKGPNKVGIVGLLQSFADLLKLVV 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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